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Compile Data Set for Download or QSAR

Found 614 hits from Asana BioSciences, LLC   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322912
PNG
(2-(1-(4-((4-(3-hydroxypiperidin-1-yl) phenyl)amino...)
Show SMILES OC1CCCN(C1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCC(CC#N)CC2)cc1
Show InChI InChI=1S/C24H28N8O2/c25-10-7-16-8-12-31(13-9-16)24-28-20-14-26-30-23(34)21(20)22(29-24)27-17-3-5-18(6-4-17)32-11-1-2-19(33)15-32/h3-6,14,16,19,33H,1-2,7-9,11-13,15H2,(H,30,34)(H,27,28,29)
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Asana BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM322913
PNG
(2-(azepan-1-yl)-4-((4-(2-(4- methylpiperazin-1-yl)...)
Show SMILES CN1CCN(CC1)C(=O)COc1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1
Show InChI InChI=1S/C25H32N8O3/c1-31-12-14-32(15-13-31)21(34)17-36-19-8-6-18(7-9-19)27-23-22-20(16-26-30-24(22)35)28-25(29-23)33-10-4-2-3-5-11-33/h6-9,16H,2-5,10-15,17H2,1H3,(H,30,35)(H,27,28,29)
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Asana BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322913
PNG
(2-(azepan-1-yl)-4-((4-(2-(4- methylpiperazin-1-yl)...)
Show SMILES CN1CCN(CC1)C(=O)COc1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1
Show InChI InChI=1S/C25H32N8O3/c1-31-12-14-32(15-13-31)21(34)17-36-19-8-6-18(7-9-19)27-23-22-20(16-26-30-24(22)35)28-25(29-23)33-10-4-2-3-5-11-33/h6-9,16H,2-5,10-15,17H2,1H3,(H,30,35)(H,27,28,29)
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Asana BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM322914
PNG
(2-(1-(4-((4-(3-(hydroxymethyl)piperidin- 1-yl)phen...)
Show SMILES OCC1CCCN(C1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCC(CC#N)CC2)cc1
Show InChI InChI=1S/C25H30N8O2/c26-10-7-17-8-12-32(13-9-17)25-29-21-14-27-31-24(35)22(21)23(30-25)28-19-3-5-20(6-4-19)33-11-1-2-18(15-33)16-34/h3-6,14,17-18,34H,1-2,7-9,11-13,15-16H2,(H,31,35)(H,28,29,30)
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Asana BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322914
PNG
(2-(1-(4-((4-(3-(hydroxymethyl)piperidin- 1-yl)phen...)
Show SMILES OCC1CCCN(C1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCC(CC#N)CC2)cc1
Show InChI InChI=1S/C25H30N8O2/c26-10-7-17-8-12-32(13-9-17)25-29-21-14-27-31-24(35)22(21)23(30-25)28-19-3-5-20(6-4-19)33-11-1-2-18(15-33)16-34/h3-6,14,17-18,34H,1-2,7-9,11-13,15-16H2,(H,31,35)(H,28,29,30)
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Asana BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322919
PNG
(2-(azepan-1-yl)-4-((4-(4-fluoropiperidin- 1-yl)phe...)
Show SMILES FC1CCN(CC1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1
Show InChI InChI=1S/C23H28FN7O/c24-16-9-13-30(14-10-16)18-7-5-17(6-8-18)26-21-20-19(15-25-29-22(20)32)27-23(28-21)31-11-3-1-2-4-12-31/h5-8,15-16H,1-4,9-14H2,(H,29,32)(H,26,27,28)
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Asana BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM322922
PNG
(2-(azepan-1-yl)-4-((4-(piperidin-4-yloxy) phenyl)a...)
Show SMILES N=[Cl]1CCC(CC1)Oc1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1
Show InChI InChI=1S/C23H29ClN7O2/c25-24-11-9-18(10-12-24)33-17-7-5-16(6-8-17)27-21-20-19(15-26-30-22(20)32)28-23(29-21)31-13-3-1-2-4-14-31/h5-8,15,18,25H,1-4,9-14H2,(H,30,32)(H,27,28,29)
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Asana BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322922
PNG
(2-(azepan-1-yl)-4-((4-(piperidin-4-yloxy) phenyl)a...)
Show SMILES N=[Cl]1CCC(CC1)Oc1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1
Show InChI InChI=1S/C23H29ClN7O2/c25-24-11-9-18(10-12-24)33-17-7-5-16(6-8-17)27-21-20-19(15-26-30-22(20)32)28-23(29-21)31-13-3-1-2-4-14-31/h5-8,15,18,25H,1-4,9-14H2,(H,30,32)(H,27,28,29)
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Asana BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM322927
PNG
(2-(1-(4-((4-(4-(1-hydroxy-2- methylpropan-2-yl)-1,...)
Show SMILES CC(C)(CO)N1CCCN(CC1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCC(CC#N)CC2)cc1
Show InChI InChI=1S/C28H37N9O2/c1-28(2,19-38)37-13-3-12-35(16-17-37)22-6-4-21(5-7-22)31-25-24-23(18-30-34-26(24)39)32-27(33-25)36-14-9-20(8-11-29)10-15-36/h4-7,18,20,38H,3,8-10,12-17,19H2,1-2H3,(H,34,39)(H,31,32,33)
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Asana BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM322934
PNG
(3-(4-((2-(azepan-1-yl)-5-oxo-5,6- dihydropyrimido[...)
Show SMILES OC(=O)CCc1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1
Show InChI InChI=1S/C21H24N6O3/c28-17(29)10-7-14-5-8-15(9-6-14)23-19-18-16(13-22-26-20(18)30)24-21(25-19)27-11-3-1-2-4-12-27/h5-6,8-9,13H,1-4,7,10-12H2,(H,26,30)(H,28,29)(H,23,24,25)
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Asana BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322934
PNG
(3-(4-((2-(azepan-1-yl)-5-oxo-5,6- dihydropyrimido[...)
Show SMILES OC(=O)CCc1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1
Show InChI InChI=1S/C21H24N6O3/c28-17(29)10-7-14-5-8-15(9-6-14)23-19-18-16(13-22-26-20(18)30)24-21(25-19)27-11-3-1-2-4-12-27/h5-6,8-9,13H,1-4,7,10-12H2,(H,26,30)(H,28,29)(H,23,24,25)
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Asana BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM322935
PNG
(3-(4-((2-(4-(cyanomethyl)piperidin-1-yl)- 5-oxo-5,...)
Show SMILES OC(=O)CCc1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCC(CC#N)CC2)cc1
Show InChI InChI=1S/C22H23N7O3/c23-10-7-15-8-11-29(12-9-15)22-26-17-13-24-28-21(32)19(17)20(27-22)25-16-4-1-14(2-5-16)3-6-18(30)31/h1-2,4-5,13,15H,3,6-9,11-12H2,(H,28,32)(H,30,31)(H,25,26,27)
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Asana BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM322936
PNG
(2-(azepan-1-yl)-4-((4-(bis(2- hydroxyethyl)amino)p...)
Show SMILES OCCN(CCO)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1
Show InChI InChI=1S/C22H29N7O3/c30-13-11-28(12-14-31)17-7-5-16(6-8-17)24-20-19-18(15-23-27-21(19)32)25-22(26-20)29-9-3-1-2-4-10-29/h5-8,15,30-31H,1-4,9-14H2,(H,27,32)(H,24,25,26)
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Asana BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322936
PNG
(2-(azepan-1-yl)-4-((4-(bis(2- hydroxyethyl)amino)p...)
Show SMILES OCCN(CCO)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1
Show InChI InChI=1S/C22H29N7O3/c30-13-11-28(12-14-31)17-7-5-16(6-8-17)24-20-19-18(15-23-27-21(19)32)25-22(26-20)29-9-3-1-2-4-10-29/h5-8,15,30-31H,1-4,9-14H2,(H,27,32)(H,24,25,26)
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Asana BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM322937
PNG
(2-(1-(4-((4-(bis(2-hydroxyethyl)amino) phenyl)amin...)
Show SMILES OCCN(CCO)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCC(CC#N)CC2)cc1
Show InChI InChI=1S/C23H28N8O3/c24-8-5-16-6-9-31(10-7-16)23-27-19-15-25-29-22(34)20(19)21(28-23)26-17-1-3-18(4-2-17)30(11-13-32)12-14-33/h1-4,15-16,32-33H,5-7,9-14H2,(H,29,34)(H,26,27,28)
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Asana BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322937
PNG
(2-(1-(4-((4-(bis(2-hydroxyethyl)amino) phenyl)amin...)
Show SMILES OCCN(CCO)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCC(CC#N)CC2)cc1
Show InChI InChI=1S/C23H28N8O3/c24-8-5-16-6-9-31(10-7-16)23-27-19-15-25-29-22(34)20(19)21(28-23)26-17-1-3-18(4-2-17)30(11-13-32)12-14-33/h1-4,15-16,32-33H,5-7,9-14H2,(H,29,34)(H,26,27,28)
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Asana BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322938
PNG
(2-(azepan-1-yl)-4-((4-(3-hydroxypropyl) phenyl)ami...)
Show SMILES OCCCc1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1
Show InChI InChI=1S/C21H26N6O2/c28-13-5-6-15-7-9-16(10-8-15)23-19-18-17(14-22-26-20(18)29)24-21(25-19)27-11-3-1-2-4-12-27/h7-10,14,28H,1-6,11-13H2,(H,26,29)(H,23,24,25)
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Asana BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322944
PNG
(2-(azepan-1-yl)-4-((4-((1-hydroxy-2- methylpropan-...)
Show SMILES CC(C)(CO)Oc1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1
Show InChI InChI=1S/C22H28N6O3/c1-22(2,14-29)31-16-9-7-15(8-10-16)24-19-18-17(13-23-27-20(18)30)25-21(26-19)28-11-5-3-4-6-12-28/h7-10,13,29H,3-6,11-12,14H2,1-2H3,(H,27,30)(H,24,25,26)
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Asana BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322946
PNG
(2-(4-((2-(azepan-1-yl)-5-oxo-5,6- dihydropyrimido[...)
Show SMILES CC(C)(Oc1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1)C(O)=O
Show InChI InChI=1S/C22H26N6O4/c1-22(2,20(30)31)32-15-9-7-14(8-10-15)24-18-17-16(13-23-27-19(17)29)25-21(26-18)28-11-5-3-4-6-12-28/h7-10,13H,3-6,11-12H2,1-2H3,(H,27,29)(H,30,31)(H,24,25,26)
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Asana BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322952
PNG
(2-(azepan-1-yl)-4-((4-(2-hydroxyethyl) phenyl)amin...)
Show SMILES OCCc1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1
Show InChI InChI=1S/C20H24N6O2/c27-12-9-14-5-7-15(8-6-14)22-18-17-16(13-21-25-19(17)28)23-20(24-18)26-10-3-1-2-4-11-26/h5-8,13,27H,1-4,9-12H2,(H,25,28)(H,22,23,24)
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Asana BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM322959
PNG
(2-(azepan-1-yl)-4-((4-((1-(2-hydroxyethyl) piperid...)
Show SMILES OCCN1CCC(CC1)Oc1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1
Show InChI InChI=1S/C25H33N7O3/c33-16-15-31-13-9-20(10-14-31)35-19-7-5-18(6-8-19)27-23-22-21(17-26-30-24(22)34)28-25(29-23)32-11-3-1-2-4-12-32/h5-8,17,20,33H,1-4,9-16H2,(H,30,34)(H,27,28,29)
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Asana BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322959
PNG
(2-(azepan-1-yl)-4-((4-((1-(2-hydroxyethyl) piperid...)
Show SMILES OCCN1CCC(CC1)Oc1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1
Show InChI InChI=1S/C25H33N7O3/c33-16-15-31-13-9-20(10-14-31)35-19-7-5-18(6-8-19)27-23-22-21(17-26-30-24(22)34)28-25(29-23)32-11-3-1-2-4-12-32/h5-8,17,20,33H,1-4,9-16H2,(H,30,34)(H,27,28,29)
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Asana BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322964
PNG
(2-(azepan-1-yl)-4-((4-(methylsulfonyl) phenyl)amin...)
Show SMILES CS(=O)(=O)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)N2CCCCCC2)cc1
Show InChI InChI=1S/C19H22N6O3S/c1-29(27,28)14-8-6-13(7-9-14)21-17-16-15(12-20-24-18(16)26)22-19(23-17)25-10-4-2-3-5-11-25/h6-9,12H,2-5,10-11H2,1H3,(H,24,26)(H,21,22,23)
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Asana BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM322969
PNG
(4-((1H-benzo[d][1,2,3]triazol-5-yl) amino)-2-(azep...)
Show SMILES O=c1[nH]ncc2nc(nc(Nc3ccc4[nH]nnc4c3)c12)N1CCCCCC1
Show InChI InChI=1S/C18H19N9O/c28-17-15-14(10-19-25-17)21-18(27-7-3-1-2-4-8-27)22-16(15)20-11-5-6-12-13(9-11)24-26-23-12/h5-6,9-10H,1-4,7-8H2,(H,25,28)(H,20,21,22)(H,23,24,26)
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Asana BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM322839
PNG
(2-(azepan-1-yl)-4-((4-(2-(4- ethylpiperazin-1-yl)e...)
Show SMILES CCN1CCN(CCc2ccc(Nc3nc(nc(C=N)c3C(N)=O)N3CCCCCC3)cc2)CC1
Show InChI InChI=1S/C26H38N8O/c1-2-32-15-17-33(18-16-32)14-11-20-7-9-21(10-8-20)29-25-23(24(28)35)22(19-27)30-26(31-25)34-12-5-3-4-6-13-34/h7-10,19,27H,2-6,11-18H2,1H3,(H2,28,35)(H,29,30,31)
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Asana BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322840
PNG
(2-(azepan-1-yl)-4-((4-(2-(4-hydroxy-4- methylpiper...)
Show SMILES CC1(O)CCN(CCc2ccc(Nc3nc(nc(C=N)c3C(N)=O)N3CCCCCC3)cc2)CC1
Show InChI InChI=1S/C26H37N7O2/c1-26(35)11-16-32(17-12-26)15-10-19-6-8-20(9-7-19)29-24-22(23(28)34)21(18-27)30-25(31-24)33-13-4-2-3-5-14-33/h6-9,18,27,35H,2-5,10-17H2,1H3,(H2,28,34)(H,29,30,31)
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Asana BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM322843
PNG
(2-(4-(4-((2-(4-(cyanomethyl)piperidin-1- yl)-5-oxo...)
Show SMILES CC(C)(N1CCN(CC1)c1ccc(Nc2nc(nc(C=N)c2C(N)=O)N2CCC(CC#N)CC2)cc1)C(O)=O
Show InChI InChI=1S/C27H35N9O3/c1-27(2,25(38)39)36-15-13-34(14-16-36)20-5-3-19(4-6-20)31-24-22(23(30)37)21(17-29)32-26(33-24)35-11-8-18(7-10-28)9-12-35/h3-6,17-18,29H,7-9,11-16H2,1-2H3,(H2,30,37)(H,38,39)(H,31,32,33)
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Asana BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM322844
PNG
(2-(azepan-1-yl)-4-((4-(4-(2-hydroxy-2- methylpropa...)
Show SMILES CC(C)(O)C(=O)N1CCN(CC1)c1ccc(Nc2nc(nc(C=N)c2C(N)=O)N2CCCCCC2)cc1
Show InChI InChI=1S/C26H36N8O3/c1-26(2,37)24(36)33-15-13-32(14-16-33)19-9-7-18(8-10-19)29-23-21(22(28)35)20(17-27)30-25(31-23)34-11-5-3-4-6-12-34/h7-10,17,27,37H,3-6,11-16H2,1-2H3,(H2,28,35)(H,29,30,31)
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Asana BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322844
PNG
(2-(azepan-1-yl)-4-((4-(4-(2-hydroxy-2- methylpropa...)
Show SMILES CC(C)(O)C(=O)N1CCN(CC1)c1ccc(Nc2nc(nc(C=N)c2C(N)=O)N2CCCCCC2)cc1
Show InChI InChI=1S/C26H36N8O3/c1-26(2,37)24(36)33-15-13-32(14-16-33)19-9-7-18(8-10-19)29-23-21(22(28)35)20(17-27)30-25(31-23)34-11-5-3-4-6-12-34/h7-10,17,27,37H,3-6,11-16H2,1-2H3,(H2,28,35)(H,29,30,31)
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Asana BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM322845
PNG
(3-(4-(4-((2-(azepan-1-yl)-5-oxo-5,6- dihydropyrimi...)
Show SMILES NC(=O)c1c(Nc2ccc(cc2)N2CCN(CC2)C(=O)CC#N)nc(nc1C=N)N1CCCCCC1
Show InChI InChI=1S/C25H31N9O2/c26-10-9-21(35)33-15-13-32(14-16-33)19-7-5-18(6-8-19)29-24-22(23(28)36)20(17-27)30-25(31-24)34-11-3-1-2-4-12-34/h5-8,17,27H,1-4,9,11-16H2,(H2,28,36)(H,29,30,31)
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Asana BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322845
PNG
(3-(4-(4-((2-(azepan-1-yl)-5-oxo-5,6- dihydropyrimi...)
Show SMILES NC(=O)c1c(Nc2ccc(cc2)N2CCN(CC2)C(=O)CC#N)nc(nc1C=N)N1CCCCCC1
Show InChI InChI=1S/C25H31N9O2/c26-10-9-21(35)33-15-13-32(14-16-33)19-7-5-18(6-8-19)29-24-22(23(28)36)20(17-27)30-25(31-24)34-11-3-1-2-4-12-34/h5-8,17,27H,1-4,9,11-16H2,(H2,28,36)(H,29,30,31)
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Asana BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM322846
PNG
(2-(1-(4-((4-(4-(hydroxymethyl)piperidin- 1-yl)phen...)
Show SMILES NC(=O)c1c(Nc2ccc(cc2)N2CCC(CO)CC2)nc(nc1C=N)N1CCC(CC#N)CC1
Show InChI InChI=1S/C25H32N8O2/c26-10-5-17-6-13-33(14-7-17)25-30-21(15-27)22(23(28)35)24(31-25)29-19-1-3-20(4-2-19)32-11-8-18(16-34)9-12-32/h1-4,15,17-18,27,34H,5-9,11-14,16H2,(H2,28,35)(H,29,30,31)
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Asana BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322846
PNG
(2-(1-(4-((4-(4-(hydroxymethyl)piperidin- 1-yl)phen...)
Show SMILES NC(=O)c1c(Nc2ccc(cc2)N2CCC(CO)CC2)nc(nc1C=N)N1CCC(CC#N)CC1
Show InChI InChI=1S/C25H32N8O2/c26-10-5-17-6-13-33(14-7-17)25-30-21(15-27)22(23(28)35)24(31-25)29-19-1-3-20(4-2-19)32-11-8-18(16-34)9-12-32/h1-4,15,17-18,27,34H,5-9,11-14,16H2,(H2,28,35)(H,29,30,31)
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Asana BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM322849
PNG
((phosphonooxy)methyl 6-(4-((2-(azepan- 1-yl)-5-oxo...)
Show SMILES NC(=O)c1c(Nc2ccc(cc2)N2CCC3(CC3C(=O)OCO)CC2)nc(nc1C=N)N1CCCCCC1
Show InChI InChI=1S/C27H35N7O4/c28-16-21-22(23(29)36)24(32-26(31-21)34-11-3-1-2-4-12-34)30-18-5-7-19(8-6-18)33-13-9-27(10-14-33)15-20(27)25(37)38-17-35/h5-8,16,20,28,35H,1-4,9-15,17H2,(H2,29,36)(H,30,31,32)
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Asana BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322849
PNG
((phosphonooxy)methyl 6-(4-((2-(azepan- 1-yl)-5-oxo...)
Show SMILES NC(=O)c1c(Nc2ccc(cc2)N2CCC3(CC3C(=O)OCO)CC2)nc(nc1C=N)N1CCCCCC1
Show InChI InChI=1S/C27H35N7O4/c28-16-21-22(23(29)36)24(32-26(31-21)34-11-3-1-2-4-12-34)30-18-5-7-19(8-6-18)33-13-9-27(10-14-33)15-20(27)25(37)38-17-35/h5-8,16,20,28,35H,1-4,9-15,17H2,(H2,29,36)(H,30,31,32)
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Asana BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM322850
PNG
(3-(4-(4-((2-(4-(cyanomethyl)piperidin-1- yl)-5-oxo...)
Show SMILES NC(=O)c1c(Nc2ccc(cc2)N2CCN(CCC(O)=O)CC2)nc(nc1C=N)N1CCC(CC#N)CC1
Show InChI InChI=1S/C26H33N9O3/c27-9-5-18-6-11-35(12-7-18)26-31-21(17-28)23(24(29)38)25(32-26)30-19-1-3-20(4-2-19)34-15-13-33(14-16-34)10-8-22(36)37/h1-4,17-18,28H,5-8,10-16H2,(H2,29,38)(H,36,37)(H,30,31,32)
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Asana BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322850
PNG
(3-(4-(4-((2-(4-(cyanomethyl)piperidin-1- yl)-5-oxo...)
Show SMILES NC(=O)c1c(Nc2ccc(cc2)N2CCN(CCC(O)=O)CC2)nc(nc1C=N)N1CCC(CC#N)CC1
Show InChI InChI=1S/C26H33N9O3/c27-9-5-18-6-11-35(12-7-18)26-31-21(17-28)23(24(29)38)25(32-26)30-19-1-3-20(4-2-19)34-15-13-33(14-16-34)10-8-22(36)37/h1-4,17-18,28H,5-8,10-16H2,(H2,29,38)(H,36,37)(H,30,31,32)
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Asana BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322851
PNG
(2-(azepan-1-yl)-4-((6-(piperazin-1-yl) pyridin-3-y...)
Show SMILES NC(=O)c1c(Nc2ccc(nc2)N2CCNCC2)nc(nc1C=N)N1CCCCCC1
Show InChI InChI=1S/C21H29N9O/c22-13-16-18(19(23)31)20(28-21(27-16)30-9-3-1-2-4-10-30)26-15-5-6-17(25-14-15)29-11-7-24-8-12-29/h5-6,13-14,22,24H,1-4,7-12H2,(H2,23,31)(H,26,27,28)
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Asana BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM322853
PNG
(2-(1-(4-((4-(4-(2-hydroxy-2- methylpropanoyl)piper...)
Show SMILES CC(C)(O)C(=O)N1CCN(CC1)c1ccc(Nc2nc(nc(C=N)c2C(N)=O)N2CCC(CC#N)CC2)cc1
Show InChI InChI=1S/C27H35N9O3/c1-27(2,39)25(38)35-15-13-34(14-16-35)20-5-3-19(4-6-20)31-24-22(23(30)37)21(17-29)32-26(33-24)36-11-8-18(7-10-28)9-12-36/h3-6,17-18,29,39H,7-9,11-16H2,1-2H3,(H2,30,37)(H,31,32,33)
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Asana BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322853
PNG
(2-(1-(4-((4-(4-(2-hydroxy-2- methylpropanoyl)piper...)
Show SMILES CC(C)(O)C(=O)N1CCN(CC1)c1ccc(Nc2nc(nc(C=N)c2C(N)=O)N2CCC(CC#N)CC2)cc1
Show InChI InChI=1S/C27H35N9O3/c1-27(2,39)25(38)35-15-13-34(14-16-35)20-5-3-19(4-6-20)31-24-22(23(30)37)21(17-29)32-26(33-24)36-11-8-18(7-10-28)9-12-36/h3-6,17-18,29,39H,7-9,11-16H2,1-2H3,(H2,30,37)(H,31,32,33)
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Asana BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322857
PNG
(4-((4-(2H-tetrazol-5-yl)phenyl)amino)-2- (azepan-1...)
Show SMILES O=c1[nH]ncc2nc(nc(Nc3ccc(cc3)-c3nn[nH]n3)c12)N1CCCCCC1
Show InChI InChI=1S/C19H20N10O/c30-18-15-14(11-20-26-18)22-19(29-9-3-1-2-4-10-29)23-17(15)21-13-7-5-12(6-8-13)16-24-27-28-25-16/h5-8,11H,1-4,9-10H2,(H,26,30)(H,21,22,23)(H,24,25,27,28)
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Asana BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322859
PNG
(2-(azepan-1-yl)-4-((6-(4-ethylpiperazin-1- yl)pyri...)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2nc(nc(C=N)c2C(N)=O)N2CCCCCC2)cn1
Show InChI InChI=1S/C23H33N9O/c1-2-30-11-13-31(14-12-30)19-8-7-17(16-26-19)27-22-20(21(25)33)18(15-24)28-23(29-22)32-9-5-3-4-6-10-32/h7-8,15-16,24H,2-6,9-14H2,1H3,(H2,25,33)(H,27,28,29)
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Asana BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322862
PNG
(2-(1-(4-((2-(azepan-1-yl)-5-oxo-5,6- dihydropyrimi...)
Show SMILES NC(=O)c1c(Nc2ccc(cc2)N2CCCC(CC(O)=O)C2)nc(nc1C=N)N1CCCCCC1
Show InChI InChI=1S/C25H33N7O3/c26-15-20-22(23(27)35)24(30-25(29-20)31-11-3-1-2-4-12-31)28-18-7-9-19(10-8-18)32-13-5-6-17(16-32)14-21(33)34/h7-10,15,17,26H,1-6,11-14,16H2,(H2,27,35)(H,33,34)(H,28,29,30)
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Asana BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM322862
PNG
(2-(1-(4-((2-(azepan-1-yl)-5-oxo-5,6- dihydropyrimi...)
Show SMILES NC(=O)c1c(Nc2ccc(cc2)N2CCCC(CC(O)=O)C2)nc(nc1C=N)N1CCCCCC1
Show InChI InChI=1S/C25H33N7O3/c26-15-20-22(23(27)35)24(30-25(29-20)31-11-3-1-2-4-12-31)28-18-7-9-19(10-8-18)32-13-5-6-17(16-32)14-21(33)34/h7-10,15,17,26H,1-6,11-14,16H2,(H2,27,35)(H,33,34)(H,28,29,30)
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Asana BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322862
PNG
(2-(1-(4-((2-(azepan-1-yl)-5-oxo-5,6- dihydropyrimi...)
Show SMILES NC(=O)c1c(Nc2ccc(cc2)N2CCCC(CC(O)=O)C2)nc(nc1C=N)N1CCCCCC1
Show InChI InChI=1S/C25H33N7O3/c26-15-20-22(23(27)35)24(30-25(29-20)31-11-3-1-2-4-12-31)28-18-7-9-19(10-8-18)32-13-5-6-17(16-32)14-21(33)34/h7-10,15,17,26H,1-6,11-14,16H2,(H2,27,35)(H,33,34)(H,28,29,30)
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Asana BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322864
PNG
(3-(4-(5-((2-(azepan-1-yl)-5-oxo-5,6- dihydropyrimi...)
Show SMILES NC(=O)c1c(Nc2ccc(nc2)N2CCN(CC2)C(=O)CC#N)nc(nc1C=N)N1CCCCCC1
Show InChI InChI=1S/C24H30N10O2/c25-8-7-20(35)33-13-11-32(12-14-33)19-6-5-17(16-28-19)29-23-21(22(27)36)18(15-26)30-24(31-23)34-9-3-1-2-4-10-34/h5-6,15-16,26H,1-4,7,9-14H2,(H2,27,36)(H,29,30,31)
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Asana BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322867
PNG
(3-(4-(5-((2-(4-(cyanomethyl)piperidin-1- yl)-5-oxo...)
Show SMILES NC(=O)c1c(Nc2ccc(nc2)N2CCN(CC2)C(=O)CC#N)nc(nc1C=N)N1CCC(CC#N)CC1
Show InChI InChI=1S/C25H29N11O2/c26-7-3-17-5-9-36(10-6-17)25-32-19(15-28)22(23(29)38)24(33-25)31-18-1-2-20(30-16-18)34-11-13-35(14-12-34)21(37)4-8-27/h1-2,15-17,28H,3-6,9-14H2,(H2,29,38)(H,31,32,33)
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Asana BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322868
PNG
(2-(azepan-1-yl)-4-((6-(4-(2-hydroxy-2- methylpropa...)
Show SMILES CC(C)(O)C(=O)N1CCN(CC1)c1ccc(Nc2nc(nc(C=N)c2C(N)=O)N2CCCCCC2)cn1
Show InChI InChI=1S/C25H35N9O3/c1-25(2,37)23(36)33-13-11-32(12-14-33)19-8-7-17(16-28-19)29-22-20(21(27)35)18(15-26)30-24(31-22)34-9-5-3-4-6-10-34/h7-8,15-16,26,37H,3-6,9-14H2,1-2H3,(H2,27,35)(H,29,30,31)
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Asana BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM322870
PNG
(3-(4-(4-((2-(4-(cyanomethyl)piperidin-1- yl)-5-oxo...)
Show SMILES NC(=O)c1c(Nc2ccc(cc2)N2CCN(CC2)C(=O)CC#N)nc(nc1C=N)N1CCC(CC#N)CC1
Show InChI InChI=1S/C26H30N10O2/c27-9-5-18-7-11-36(12-8-18)26-32-21(17-29)23(24(30)38)25(33-26)31-19-1-3-20(4-2-19)34-13-15-35(16-14-34)22(37)6-10-28/h1-4,17-18,29H,5-8,11-16H2,(H2,30,38)(H,31,32,33)
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Asana BioSciences, LLC

US Patent


Assay Description
Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM322874
PNG
(4-((4-(4-((2H-tetrazol-5-yl)methyl) piperidin-1-yl...)
Show SMILES O=c1[nH]ncc2nc(nc(Nc3ccc(cc3)N3CCC(Cc4nn[nH]n4)CC3)c12)N1CCCCCC1
Show InChI InChI=1S/C25H31N11O/c37-24-22-20(16-26-32-24)28-25(36-11-3-1-2-4-12-36)29-23(22)27-18-5-7-19(8-6-18)35-13-9-17(10-14-35)15-21-30-33-34-31-21/h5-8,16-17H,1-4,9-15H2,(H,32,37)(H,27,28,29)(H,30,31,33,34)
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Asana BioSciences, LLC

US Patent


Assay Description
2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...


US Patent US10183944 (2019)

More data for this
Ligand-Target Pair
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