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Compile Data Set for Download or QSAR

Found 387 hits from Astex Therapeutics Limited   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM139913
PNG
(US8895745, 375)
Show SMILES Cn1cnc(c1)-c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C20H17F3N6O/c1-28-10-16(26-12-28)13-5-6-29-17(9-24-18(29)8-13)14-3-2-4-15(7-14)27-19(30)25-11-20(21,22)23/h2-10,12H,11H2,1H3,(H2,25,27,30)
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US Patent
n/an/a 0.490n/an/an/an/a7.5n/a



Astex Therapeutics Limited

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2x final concentration in 1x kinase assay buffer (as described below). Enzymes were then incubated with test ...


US Patent US8895745 (2014)


BindingDB Entry DOI: 10.7270/Q2833QQC
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM139918
PNG
(US8895745, 401)
Show SMILES OCCn1cc(cn1)-c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C21H19F3N6O2/c22-21(23,24)13-26-20(32)28-17-3-1-2-15(8-17)18-11-25-19-9-14(4-5-30(18)19)16-10-27-29(12-16)6-7-31/h1-5,8-12,31H,6-7,13H2,(H2,26,28,32)
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n/an/a 0.704n/an/an/an/a7.5n/a



Astex Therapeutics Limited

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2x final concentration in 1x kinase assay buffer (as described below). Enzymes were then incubated with test ...


US Patent US8895745 (2014)


BindingDB Entry DOI: 10.7270/Q2833QQC
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM139909
PNG
(US8895745, 310)
Show SMILES Cc1nnc(s1)-c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C19H15F3N6OS/c1-11-26-27-17(30-11)13-5-6-28-15(9-23-16(28)8-13)12-3-2-4-14(7-12)25-18(29)24-10-19(20,21)22/h2-9H,10H2,1H3,(H2,24,25,29)
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n/an/a 0.780n/an/an/an/a7.5n/a



Astex Therapeutics Limited

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2x final concentration in 1x kinase assay buffer (as described below). Enzymes were then incubated with test ...


US Patent US8895745 (2014)


BindingDB Entry DOI: 10.7270/Q2833QQC
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM139914
PNG
(US8895745, 378)
Show SMILES Cc1c(nnn1C)-c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C20H18F3N7O/c1-12-18(27-28-29(12)2)14-6-7-30-16(10-24-17(30)9-14)13-4-3-5-15(8-13)26-19(31)25-11-20(21,22)23/h3-10H,11H2,1-2H3,(H2,25,26,31)
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n/an/a 0.790n/an/an/an/a7.5n/a



Astex Therapeutics Limited

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2x final concentration in 1x kinase assay buffer (as described below). Enzymes were then incubated with test ...


US Patent US8895745 (2014)


BindingDB Entry DOI: 10.7270/Q2833QQC
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM139920
PNG
(US8895745, 412)
Show SMILES Cc1nc(c(C)n1C)-c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C22H21F3N6O/c1-13-20(28-14(2)30(13)3)16-7-8-31-18(11-26-19(31)10-16)15-5-4-6-17(9-15)29-21(32)27-12-22(23,24)25/h4-11H,12H2,1-3H3,(H2,27,29,32)
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n/an/a 1.24n/an/an/an/a7.5n/a



Astex Therapeutics Limited

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2x final concentration in 1x kinase assay buffer (as described below). Enzymes were then incubated with test ...


US Patent US8895745 (2014)


BindingDB Entry DOI: 10.7270/Q2833QQC
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM139924
PNG
(US8895745, 402)
Show SMILES NCCn1cc(cn1)-c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C21H20F3N7O/c22-21(23,24)13-27-20(32)29-17-3-1-2-15(8-17)18-11-26-19-9-14(4-6-31(18)19)16-10-28-30(12-16)7-5-25/h1-4,6,8-12H,5,7,13,25H2,(H2,27,29,32)
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n/an/a 1.60n/an/an/an/a7.5n/a



Astex Therapeutics Limited

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2x final concentration in 1x kinase assay buffer (as described below). Enzymes were then incubated with test ...


US Patent US8895745 (2014)


BindingDB Entry DOI: 10.7270/Q2833QQC
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM139915
PNG
(US8895745, 384)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(ccn12)-c1nncs1
Show InChI InChI=1S/C18H13F3N6OS/c19-18(20,21)9-23-17(28)25-13-3-1-2-11(6-13)14-8-22-15-7-12(4-5-27(14)15)16-26-24-10-29-16/h1-8,10H,9H2,(H2,23,25,28)
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n/an/a 1.90n/an/an/an/a7.5n/a



Astex Therapeutics Limited

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2x final concentration in 1x kinase assay buffer (as described below). Enzymes were then incubated with test ...


US Patent US8895745 (2014)


BindingDB Entry DOI: 10.7270/Q2833QQC
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM139921
PNG
(US8895745, 416)
Show SMILES Cc1cn(cn1)-c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C20H17F3N6O/c1-13-10-28(12-26-13)16-5-6-29-17(9-24-18(29)8-16)14-3-2-4-15(7-14)27-19(30)25-11-20(21,22)23/h2-10,12H,11H2,1H3,(H2,25,27,30)
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n/an/a 2.18n/an/an/an/a7.5n/a



Astex Therapeutics Limited

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2x final concentration in 1x kinase assay buffer (as described below). Enzymes were then incubated with test ...


US Patent US8895745 (2014)


BindingDB Entry DOI: 10.7270/Q2833QQC
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM139922
PNG
(US8895745, 421)
Show SMILES Cc1ccc(nn1)-c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C21H17F3N6O/c1-13-5-6-17(29-28-13)14-7-8-30-18(11-25-19(30)10-14)15-3-2-4-16(9-15)27-20(31)26-12-21(22,23)24/h2-11H,12H2,1H3,(H2,26,27,31)
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n/an/a 2.60n/an/an/an/a7.5n/a



Astex Therapeutics Limited

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2x final concentration in 1x kinase assay buffer (as described below). Enzymes were then incubated with test ...


US Patent US8895745 (2014)


BindingDB Entry DOI: 10.7270/Q2833QQC
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM139923
PNG
(US8895745, 422)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(ccn12)-c1ncns1
Show InChI InChI=1S/C18H13F3N6OS/c19-18(20,21)9-23-17(28)26-13-3-1-2-11(6-13)14-8-22-15-7-12(4-5-27(14)15)16-24-10-25-29-16/h1-8,10H,9H2,(H2,23,26,28)
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n/an/a 3.30n/an/an/an/a7.5n/a



Astex Therapeutics Limited

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2x final concentration in 1x kinase assay buffer (as described below). Enzymes were then incubated with test ...


US Patent US8895745 (2014)


BindingDB Entry DOI: 10.7270/Q2833QQC
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM139908
PNG
(US8895745, 59)
Show SMILES Fc1ccc(cc1)-c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C22H16F4N4O/c23-17-6-4-14(5-7-17)15-8-9-30-19(12-27-20(30)11-15)16-2-1-3-18(10-16)29-21(31)28-13-22(24,25)26/h1-12H,13H2,(H2,28,29,31)
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n/an/a 3.30n/an/an/an/a7.5n/a



Astex Therapeutics Limited

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2x final concentration in 1x kinase assay buffer (as described below). Enzymes were then incubated with test ...


US Patent US8895745 (2014)


BindingDB Entry DOI: 10.7270/Q2833QQC
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM139917
PNG
(US8895745, 399)
Show SMILES Cc1nsc(n1)-c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C19H15F3N6OS/c1-11-25-17(30-27-11)13-5-6-28-15(9-23-16(28)8-13)12-3-2-4-14(7-12)26-18(29)24-10-19(20,21)22/h2-9H,10H2,1H3,(H2,24,26,29)
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n/an/a 4.74n/an/an/an/a7.5n/a



Astex Therapeutics Limited

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2x final concentration in 1x kinase assay buffer (as described below). Enzymes were then incubated with test ...


US Patent US8895745 (2014)


BindingDB Entry DOI: 10.7270/Q2833QQC
More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 2


(Homo sapiens (Human))
BDBM156026
PNG
(US9018214, 77)
Show SMILES COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2cnc(Cc3ccccc3F)cc12
Show InChI InChI=1S/C25H33FN4O2/c1-17-13-29(20(11-27-17)15-32-4)14-24(31)30-16-25(2,3)21-12-28-19(10-23(21)30)9-18-7-5-6-8-22(18)26/h5-8,10,12,17,20,27H,9,11,13-16H2,1-4H3/t17-,20-/m1/s1
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n/an/a 9n/an/an/an/an/an/a



Astex Therapeutics Limited

US Patent


Assay Description
Modified SMAC peptides and compounds were tested for their ability to displace the fluorescent tracer from either XIAP, clAP-1 or clAP-2. BIR3 domain...


US Patent US9018214 (2015)


BindingDB Entry DOI: 10.7270/Q23T9FXQ
More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 2


(Homo sapiens (Human))
BDBM156180
PNG
(US9018214, 231)
Show SMILES C[C@@H]1CN(CC(=O)N2CC(C)(C)c3ncc(cc23)C(F)(F)CC2CC2)[C@@H](CN2CCOCC2)CN1
Show InChI InChI=1S/C26H39F2N5O2/c1-18-14-32(21(13-29-18)15-31-6-8-35-9-7-31)16-23(34)33-17-25(2,3)24-22(33)10-20(12-30-24)26(27,28)11-19-4-5-19/h10,12,18-19,21,29H,4-9,11,13-17H2,1-3H3/t18-,21-/m1/s1
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n/an/a 9.5n/an/an/an/an/an/a



Astex Therapeutics Limited

US Patent


Assay Description
Modified SMAC peptides and compounds were tested for their ability to displace the fluorescent tracer from either XIAP, clAP-1 or clAP-2. BIR3 domain...


US Patent US9018214 (2015)


BindingDB Entry DOI: 10.7270/Q23T9FXQ
More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 2


(Homo sapiens (Human))
BDBM156012
PNG
(US9018214, 63)
Show SMILES COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2cnc(Cc3ccccc3)cc12
Show InChI InChI=1S/C25H34N4O2/c1-18-14-28(21(12-26-18)16-31-4)15-24(30)29-17-25(2,3)22-13-27-20(11-23(22)29)10-19-8-6-5-7-9-19/h5-9,11,13,18,21,26H,10,12,14-17H2,1-4H3/t18-,21-/m1/s1
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n/an/a 10n/an/an/an/an/an/a



Astex Therapeutics Limited

US Patent


Assay Description
Modified SMAC peptides and compounds were tested for their ability to displace the fluorescent tracer from either XIAP, clAP-1 or clAP-2. BIR3 domain...


US Patent US9018214 (2015)


BindingDB Entry DOI: 10.7270/Q23T9FXQ
More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 2


(Homo sapiens (Human))
BDBM156124
PNG
(US9018214, 175)
Show SMILES COC[C@H]1CN[C@H](C)CN1CC(=O)N1C[C@@](C)(c2cc(C)no2)c2ccc(Cc3ccccc3)cc12
Show InChI InChI=1S/C29H36N4O3/c1-20-12-27(36-31-20)29(3)19-33(28(34)17-32-16-21(2)30-15-24(32)18-35-4)26-14-23(10-11-25(26)29)13-22-8-6-5-7-9-22/h5-12,14,21,24,30H,13,15-19H2,1-4H3/t21-,24-,29-/m1/s1
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n/an/a 11n/an/an/an/an/an/a



Astex Therapeutics Limited

US Patent


Assay Description
Modified SMAC peptides and compounds were tested for their ability to displace the fluorescent tracer from either XIAP, clAP-1 or clAP-2. BIR3 domain...


US Patent US9018214 (2015)


BindingDB Entry DOI: 10.7270/Q23T9FXQ
More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 2


(Homo sapiens (Human))
BDBM156135
PNG
(US9018214, 186)
Show SMILES CCC(F)(F)c1cnc2c(c1)N(CC2(C)C)C(=O)CN1C[C@@H](C)NC[C@@H]1CN1CCOC[C@H]1C
Show InChI InChI=1S/C25H39F2N5O2/c1-6-25(26,27)19-9-21-23(29-10-19)24(4,5)16-32(21)22(33)14-31-12-17(2)28-11-20(31)13-30-7-8-34-15-18(30)3/h9-10,17-18,20,28H,6-8,11-16H2,1-5H3/t17-,18-,20-/m1/s1
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n/an/a 11n/an/an/an/an/an/a



Astex Therapeutics Limited

US Patent


Assay Description
Modified SMAC peptides and compounds were tested for their ability to displace the fluorescent tracer from either XIAP, clAP-1 or clAP-2. BIR3 domain...


US Patent US9018214 (2015)


BindingDB Entry DOI: 10.7270/Q23T9FXQ
More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 2


(Homo sapiens (Human))
BDBM156119
PNG
(US9018214, 170)
Show SMILES C[C@@H]1CN(CC(=O)N2CC(C)(C)c3ncc(Cc4ccccc4)cc23)[C@H](CN1)C(=O)N(C)C
Show InChI InChI=1S/C26H35N5O2/c1-18-15-30(22(14-27-18)25(33)29(4)5)16-23(32)31-17-26(2,3)24-21(31)12-20(13-28-24)11-19-9-7-6-8-10-19/h6-10,12-13,18,22,27H,11,14-17H2,1-5H3/t18-,22-/m1/s1
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n/an/a 11n/an/an/an/an/an/a



Astex Therapeutics Limited

US Patent


Assay Description
Modified SMAC peptides and compounds were tested for their ability to displace the fluorescent tracer from either XIAP, clAP-1 or clAP-2. BIR3 domain...


US Patent US9018214 (2015)


BindingDB Entry DOI: 10.7270/Q23T9FXQ
More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 2


(Homo sapiens (Human))
BDBM156035
PNG
(US9018214, 86)
Show SMILES COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2cnc(Cc3cccc(Cl)c3)cc12
Show InChI InChI=1S/C25H33ClN4O2/c1-17-13-29(21(11-27-17)15-32-4)14-24(31)30-16-25(2,3)22-12-28-20(10-23(22)30)9-18-6-5-7-19(26)8-18/h5-8,10,12,17,21,27H,9,11,13-16H2,1-4H3/t17-,21-/m1/s1
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n/an/a 12n/an/an/an/an/an/a



Astex Therapeutics Limited

US Patent


Assay Description
Modified SMAC peptides and compounds were tested for their ability to displace the fluorescent tracer from either XIAP, clAP-1 or clAP-2. BIR3 domain...


US Patent US9018214 (2015)


BindingDB Entry DOI: 10.7270/Q23T9FXQ
More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 2


(Homo sapiens (Human))
BDBM156048
PNG
(US9018214, 99)
Show SMILES C[C@@H]1CN(CC(=O)N2CC(C)(C)c3cnc(Cc4ccccc4)cc23)[C@H](CN1)C(=O)N(C)C
Show InChI InChI=1S/C26H35N5O2/c1-18-15-30(23(14-27-18)25(33)29(4)5)16-24(32)31-17-26(2,3)21-13-28-20(12-22(21)31)11-19-9-7-6-8-10-19/h6-10,12-13,18,23,27H,11,14-17H2,1-5H3/t18-,23-/m1/s1
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n/an/a 12n/an/an/an/an/an/a



Astex Therapeutics Limited

US Patent


Assay Description
Modified SMAC peptides and compounds were tested for their ability to displace the fluorescent tracer from either XIAP, clAP-1 or clAP-2. BIR3 domain...


US Patent US9018214 (2015)


BindingDB Entry DOI: 10.7270/Q23T9FXQ
More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 2


(Homo sapiens (Human))
BDBM156093
PNG
(US9018214, 144)
Show SMILES COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(c2ccc(Cc3ccccc3)cc12)c1ccccn1
Show InChI InChI=1S/C30H36N4O2/c1-22-18-33(25(17-32-22)20-36-3)19-29(35)34-21-30(2,28-11-7-8-14-31-28)26-13-12-24(16-27(26)34)15-23-9-5-4-6-10-23/h4-14,16,22,25,32H,15,17-21H2,1-3H3/t22-,25-,30?/m1/s1
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n/an/a 12n/an/an/an/an/an/a



Astex Therapeutics Limited

US Patent


Assay Description
Modified SMAC peptides and compounds were tested for their ability to displace the fluorescent tracer from either XIAP, clAP-1 or clAP-2. BIR3 domain...


US Patent US9018214 (2015)


BindingDB Entry DOI: 10.7270/Q23T9FXQ
More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 2


(Homo sapiens (Human))
BDBM156112
PNG
(US9018214, 163)
Show SMILES COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(c2ccc(Cc3ccccc3)cc12)c1cccnc1
Show InChI InChI=1S/C30H36N4O2/c1-22-18-33(26(17-32-22)20-36-3)19-29(35)34-21-30(2,25-10-7-13-31-16-25)27-12-11-24(15-28(27)34)14-23-8-5-4-6-9-23/h4-13,15-16,22,26,32H,14,17-21H2,1-3H3/t22-,26-,30?/m1/s1
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n/an/a 13n/an/an/an/an/an/a



Astex Therapeutics Limited

US Patent


Assay Description
Modified SMAC peptides and compounds were tested for their ability to displace the fluorescent tracer from either XIAP, clAP-1 or clAP-2. BIR3 domain...


US Patent US9018214 (2015)


BindingDB Entry DOI: 10.7270/Q23T9FXQ
More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 2


(Homo sapiens (Human))
BDBM156099
PNG
(US9018214, 150)
Show SMILES COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2cnc(cc12)-c1cc2ccccc2o1
Show InChI InChI=1S/C26H32N4O3/c1-17-13-29(19(11-27-17)15-32-4)14-25(31)30-16-26(2,3)20-12-28-21(10-22(20)30)24-9-18-7-5-6-8-23(18)33-24/h5-10,12,17,19,27H,11,13-16H2,1-4H3/t17-,19-/m1/s1
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n/an/a 14n/an/an/an/an/an/a



Astex Therapeutics Limited

US Patent


Assay Description
Modified SMAC peptides and compounds were tested for their ability to displace the fluorescent tracer from either XIAP, clAP-1 or clAP-2. BIR3 domain...


US Patent US9018214 (2015)


BindingDB Entry DOI: 10.7270/Q23T9FXQ
More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 2


(Homo sapiens (Human))
BDBM156086
PNG
(US9018214, 137)
Show SMILES COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2ncc(Cc3ccccc3)cc12
Show InChI InChI=1S/C25H34N4O2/c1-18-14-28(21(13-26-18)16-31-4)15-23(30)29-17-25(2,3)24-22(29)11-20(12-27-24)10-19-8-6-5-7-9-19/h5-9,11-12,18,21,26H,10,13-17H2,1-4H3/t18-,21-/m1/s1
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n/an/a 14n/an/an/an/an/an/a



Astex Therapeutics Limited

US Patent


Assay Description
Modified SMAC peptides and compounds were tested for their ability to displace the fluorescent tracer from either XIAP, clAP-1 or clAP-2. BIR3 domain...


US Patent US9018214 (2015)


BindingDB Entry DOI: 10.7270/Q23T9FXQ
More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 2


(Homo sapiens (Human))
BDBM156049
PNG
(US9018214, 100)
Show SMILES C[C@@H]1CN(CC(=O)N2CC(C)(C)c3cnc(Cc4ccccc4)cc23)[C@H](CN1)C(=O)N1CCC1
Show InChI InChI=1S/C27H35N5O2/c1-19-16-31(24(15-28-19)26(34)30-10-7-11-30)17-25(33)32-18-27(2,3)22-14-29-21(13-23(22)32)12-20-8-5-4-6-9-20/h4-6,8-9,13-14,19,24,28H,7,10-12,15-18H2,1-3H3/t19-,24-/m1/s1
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n/an/a 14n/an/an/an/an/an/a



Astex Therapeutics Limited

US Patent


Assay Description
Modified SMAC peptides and compounds were tested for their ability to displace the fluorescent tracer from either XIAP, clAP-1 or clAP-2. BIR3 domain...


US Patent US9018214 (2015)


BindingDB Entry DOI: 10.7270/Q23T9FXQ
More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 2


(Homo sapiens (Human))
BDBM156043
PNG
(US9018214, 94)
Show SMILES COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2ccc(Cc3ccccc3)cc12
Show InChI InChI=1S/C26H35N3O2/c1-19-15-28(22(14-27-19)17-31-4)16-25(30)29-18-26(2,3)23-11-10-21(13-24(23)29)12-20-8-6-5-7-9-20/h5-11,13,19,22,27H,12,14-18H2,1-4H3/t19-,22-/m1/s1
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n/an/a 14n/an/an/an/an/an/a



Astex Therapeutics Limited

US Patent


Assay Description
Modified SMAC peptides and compounds were tested for their ability to displace the fluorescent tracer from either XIAP, clAP-1 or clAP-2. BIR3 domain...


US Patent US9018214 (2015)


BindingDB Entry DOI: 10.7270/Q23T9FXQ
More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 2


(Homo sapiens (Human))
BDBM156204
PNG
(US9018214, 255)
Show SMILES CC[C@@H]1COCCN1C[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2ncc(cc12)C(F)(F)CC
Show InChI InChI=1S/C26H41F2N5O2/c1-6-20-16-35-9-8-31(20)14-21-12-29-18(3)13-32(21)15-23(34)33-17-25(4,5)24-22(33)10-19(11-30-24)26(27,28)7-2/h10-11,18,20-21,29H,6-9,12-17H2,1-5H3/t18-,20-,21-/m1/s1
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n/an/a 14n/an/an/an/an/an/a



Astex Therapeutics Limited

US Patent


Assay Description
Modified SMAC peptides and compounds were tested for their ability to displace the fluorescent tracer from either XIAP, clAP-1 or clAP-2. BIR3 domain...


US Patent US9018214 (2015)


BindingDB Entry DOI: 10.7270/Q23T9FXQ
More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 2


(Homo sapiens (Human))
BDBM156169
PNG
(US9018214, 220)
Show SMILES C[C@@H]1CN(CC(=O)N2CC(C)(C)c3cnc(Cc4ccc(F)cc4F)cc23)[C@@H](CN2CCCC2)CN1
Show InChI InChI=1S/C28H37F2N5O/c1-19-15-34(23(13-31-19)16-33-8-4-5-9-33)17-27(36)35-18-28(2,3)24-14-32-22(12-26(24)35)10-20-6-7-21(29)11-25(20)30/h6-7,11-12,14,19,23,31H,4-5,8-10,13,15-18H2,1-3H3/t19-,23-/m1/s1
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Astex Therapeutics Limited

US Patent


Assay Description
Modified SMAC peptides and compounds were tested for their ability to displace the fluorescent tracer from either XIAP, clAP-1 or clAP-2. BIR3 domain...


US Patent US9018214 (2015)


BindingDB Entry DOI: 10.7270/Q23T9FXQ
More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 2


(Homo sapiens (Human))
BDBM156161
PNG
(US9018214, 212)
Show SMILES C[C@@H]1CN(CC(=O)N2CC(C)(C)c3cnc(cc23)C(F)(F)C2CC2)[C@@H](CN2CCCC2=O)CN1
Show InChI InChI=1S/C25H35F2N5O2/c1-16-12-31(18(10-28-16)13-30-8-4-5-22(30)33)14-23(34)32-15-24(2,3)19-11-29-21(9-20(19)32)25(26,27)17-6-7-17/h9,11,16-18,28H,4-8,10,12-15H2,1-3H3/t16-,18-/m1/s1
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Astex Therapeutics Limited

US Patent


Assay Description
Modified SMAC peptides and compounds were tested for their ability to displace the fluorescent tracer from either XIAP, clAP-1 or clAP-2. BIR3 domain...


US Patent US9018214 (2015)


BindingDB Entry DOI: 10.7270/Q23T9FXQ
More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 2


(Homo sapiens (Human))
BDBM156138
PNG
(US9018214, 189)
Show SMILES C[C@@H]1CN(CC(=O)N2CC(C)(C)c3cnc(Oc4ccccc4Cl)cc23)[C@@H](CN2CCOC2=O)CN1
Show InChI InChI=1S/C26H32ClN5O4/c1-17-13-31(18(11-28-17)14-30-8-9-35-25(30)34)15-24(33)32-16-26(2,3)19-12-29-23(10-21(19)32)36-22-7-5-4-6-20(22)27/h4-7,10,12,17-18,28H,8-9,11,13-16H2,1-3H3/t17-,18-/m1/s1
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Astex Therapeutics Limited

US Patent


Assay Description
Modified SMAC peptides and compounds were tested for their ability to displace the fluorescent tracer from either XIAP, clAP-1 or clAP-2. BIR3 domain...


US Patent US9018214 (2015)


BindingDB Entry DOI: 10.7270/Q23T9FXQ
More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 2


(Homo sapiens (Human))
BDBM156114
PNG
(US9018214, 165)
Show SMILES C[C@@H]1CN(CC(=O)N2CC(C)(C)c3cnc(Oc4ccccc4Cl)cc23)[C@H](CN1)C(=O)N1CCOCC1
Show InChI InChI=1S/C27H34ClN5O4/c1-18-15-32(22(14-29-18)26(35)31-8-10-36-11-9-31)16-25(34)33-17-27(2,3)19-13-30-24(12-21(19)33)37-23-7-5-4-6-20(23)28/h4-7,12-13,18,22,29H,8-11,14-17H2,1-3H3/t18-,22-/m1/s1
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Astex Therapeutics Limited

US Patent


Assay Description
Modified SMAC peptides and compounds were tested for their ability to displace the fluorescent tracer from either XIAP, clAP-1 or clAP-2. BIR3 domain...


US Patent US9018214 (2015)


BindingDB Entry DOI: 10.7270/Q23T9FXQ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM139910
PNG
(US8895745, 329)
Show SMILES Cc1nnc(o1)-c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C19H15F3N6O2/c1-11-26-27-17(30-11)13-5-6-28-15(9-23-16(28)8-13)12-3-2-4-14(7-12)25-18(29)24-10-19(20,21)22/h2-9H,10H2,1H3,(H2,24,25,29)
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n/an/a 15.8n/an/an/an/a7.5n/a



Astex Therapeutics Limited

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2x final concentration in 1x kinase assay buffer (as described below). Enzymes were then incubated with test ...


US Patent US8895745 (2014)


BindingDB Entry DOI: 10.7270/Q2833QQC
More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 2


(Homo sapiens (Human))
BDBM156024
PNG
(US9018214, 75)
Show SMILES COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2cnc(CCC(C)C)cc12
Show InChI InChI=1S/C23H38N4O2/c1-16(2)7-8-18-9-21-20(11-25-18)23(4,5)15-27(21)22(28)13-26-12-17(3)24-10-19(26)14-29-6/h9,11,16-17,19,24H,7-8,10,12-15H2,1-6H3/t17-,19-/m1/s1
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n/an/a 16n/an/an/an/an/an/a



Astex Therapeutics Limited

US Patent


Assay Description
Modified SMAC peptides and compounds were tested for their ability to displace the fluorescent tracer from either XIAP, clAP-1 or clAP-2. BIR3 domain...


US Patent US9018214 (2015)


BindingDB Entry DOI: 10.7270/Q23T9FXQ
More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 2


(Homo sapiens (Human))
BDBM156038
PNG
(US9018214, 89)
Show SMILES COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2cnc(Cc3cccc(OC)c3)cc12
Show InChI InChI=1S/C26H36N4O3/c1-18-14-29(21(12-27-18)16-32-4)15-25(31)30-17-26(2,3)23-13-28-20(11-24(23)30)9-19-7-6-8-22(10-19)33-5/h6-8,10-11,13,18,21,27H,9,12,14-17H2,1-5H3/t18-,21-/m1/s1
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n/an/a 16n/an/an/an/an/an/a



Astex Therapeutics Limited

US Patent


Assay Description
Modified SMAC peptides and compounds were tested for their ability to displace the fluorescent tracer from either XIAP, clAP-1 or clAP-2. BIR3 domain...


US Patent US9018214 (2015)


BindingDB Entry DOI: 10.7270/Q23T9FXQ
More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 2


(Homo sapiens (Human))
BDBM156025
PNG
(US9018214, 76)
Show SMILES COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC2(CN(C2)C(C)=O)c2ccc(Cc3ccccc3)cc12
Show InChI InChI=1S/C28H36N4O3/c1-20-14-30(24(13-29-20)16-35-3)15-27(34)32-19-28(17-31(18-28)21(2)33)25-10-9-23(12-26(25)32)11-22-7-5-4-6-8-22/h4-10,12,20,24,29H,11,13-19H2,1-3H3/t20-,24-/m1/s1
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n/an/a 16n/an/an/an/an/an/a



Astex Therapeutics Limited

US Patent


Assay Description
Modified SMAC peptides and compounds were tested for their ability to displace the fluorescent tracer from either XIAP, clAP-1 or clAP-2. BIR3 domain...


US Patent US9018214 (2015)


BindingDB Entry DOI: 10.7270/Q23T9FXQ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM139912
PNG
(US8895745, 359)
Show SMILES CN(N)\N=C(/N)c1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C18H19F3N8O/c1-28(23)27-16(22)12-5-6-29-14(9-24-15(29)8-12)11-3-2-4-13(7-11)26-17(30)25-10-18(19,20)21/h2-9H,10,23H2,1H3,(H2,22,27)(H2,25,26,30)
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Astex Therapeutics Limited

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2x final concentration in 1x kinase assay buffer (as described below). Enzymes were then incubated with test ...


US Patent US8895745 (2014)


BindingDB Entry DOI: 10.7270/Q2833QQC
More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 2


(Homo sapiens (Human))
BDBM156046
PNG
(US9018214, 97)
Show SMILES COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2cnc(Cc3cccc(F)c3)cc12
Show InChI InChI=1S/C25H33FN4O2/c1-17-13-29(21(11-27-17)15-32-4)14-24(31)30-16-25(2,3)22-12-28-20(10-23(22)30)9-18-6-5-7-19(26)8-18/h5-8,10,12,17,21,27H,9,11,13-16H2,1-4H3/t17-,21-/m1/s1
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n/an/a 17n/an/an/an/an/an/a



Astex Therapeutics Limited

US Patent


Assay Description
Modified SMAC peptides and compounds were tested for their ability to displace the fluorescent tracer from either XIAP, clAP-1 or clAP-2. BIR3 domain...


US Patent US9018214 (2015)


BindingDB Entry DOI: 10.7270/Q23T9FXQ
More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 2


(Homo sapiens (Human))
BDBM156095
PNG
(US9018214, 146)
Show SMILES COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2cnc(cc12)C(F)(F)c1ccccc1
Show InChI InChI=1S/C25H32F2N4O2/c1-17-13-30(19(11-28-17)15-33-4)14-23(32)31-16-24(2,3)20-12-29-22(10-21(20)31)25(26,27)18-8-6-5-7-9-18/h5-10,12,17,19,28H,11,13-16H2,1-4H3/t17-,19-/m1/s1
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Astex Therapeutics Limited

US Patent


Assay Description
Modified SMAC peptides and compounds were tested for their ability to displace the fluorescent tracer from either XIAP, clAP-1 or clAP-2. BIR3 domain...


US Patent US9018214 (2015)


BindingDB Entry DOI: 10.7270/Q23T9FXQ
More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 2


(Homo sapiens (Human))
BDBM156016
PNG
(US9018214, 67)
Show SMILES COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2cc(=O)n(Cc3ccccc3)cc12
Show InChI InChI=1S/C25H34N4O3/c1-18-12-27(20(11-26-18)16-32-4)15-24(31)29-17-25(2,3)21-10-23(30)28(14-22(21)29)13-19-8-6-5-7-9-19/h5-10,14,18,20,26H,11-13,15-17H2,1-4H3/t18-,20-/m1/s1
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n/an/a 17n/an/an/an/an/an/a



Astex Therapeutics Limited

US Patent


Assay Description
Modified SMAC peptides and compounds were tested for their ability to displace the fluorescent tracer from either XIAP, clAP-1 or clAP-2. BIR3 domain...


US Patent US9018214 (2015)


BindingDB Entry DOI: 10.7270/Q23T9FXQ
More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 2


(Homo sapiens (Human))
BDBM156202
PNG
(US9018214, 253)
Show SMILES CC[C@@H]1COCCN1C[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2ncc(cc12)C(C)(F)F
Show InChI InChI=1S/C25H39F2N5O2/c1-6-19-15-34-8-7-30(19)13-20-11-28-17(2)12-31(20)14-22(33)32-16-24(3,4)23-21(32)9-18(10-29-23)25(5,26)27/h9-10,17,19-20,28H,6-8,11-16H2,1-5H3/t17-,19-,20-/m1/s1
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n/an/a 17n/an/an/an/an/an/a



Astex Therapeutics Limited

US Patent


Assay Description
Modified SMAC peptides and compounds were tested for their ability to displace the fluorescent tracer from either XIAP, clAP-1 or clAP-2. BIR3 domain...


US Patent US9018214 (2015)


BindingDB Entry DOI: 10.7270/Q23T9FXQ
More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 2


(Homo sapiens (Human))
BDBM156126
PNG
(US9018214, 177)
Show SMILES C[C@@H]1CN(CC(=O)N2CC(C)(C)c3cnc(Oc4ccccc4Cl)cc23)[C@@H](Cn2cc(F)cn2)CN1
Show InChI InChI=1S/C26H30ClFN6O2/c1-17-12-32(19(10-29-17)14-33-13-18(28)9-31-33)15-25(35)34-16-26(2,3)20-11-30-24(8-22(20)34)36-23-7-5-4-6-21(23)27/h4-9,11,13,17,19,29H,10,12,14-16H2,1-3H3/t17-,19-/m1/s1
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Astex Therapeutics Limited

US Patent


Assay Description
Modified SMAC peptides and compounds were tested for their ability to displace the fluorescent tracer from either XIAP, clAP-1 or clAP-2. BIR3 domain...


US Patent US9018214 (2015)


BindingDB Entry DOI: 10.7270/Q23T9FXQ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM139916
PNG
(US8895745, 396)
Show SMILES CC#Cc1ccn2c(cnc2c1)-c1cccc(NC(=O)NCC(F)(F)F)c1
Show InChI InChI=1S/C19H15F3N4O/c1-2-4-13-7-8-26-16(11-23-17(26)9-13)14-5-3-6-15(10-14)25-18(27)24-12-19(20,21)22/h3,5-11H,12H2,1H3,(H2,24,25,27)
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n/an/a 18.3n/an/an/an/a7.5n/a



Astex Therapeutics Limited

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2x final concentration in 1x kinase assay buffer (as described below). Enzymes were then incubated with test ...


US Patent US8895745 (2014)


BindingDB Entry DOI: 10.7270/Q2833QQC
More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 2


(Homo sapiens (Human))
BDBM156100
PNG
(US9018214, 151)
Show SMILES C[C@@H]1CN(CC(=O)N2CC(C)(C)c3cnc(Oc4ccccc4Cl)cc23)[C@H](CN1)C(=O)N(C)C
Show InChI InChI=1S/C25H32ClN5O3/c1-16-13-30(20(12-27-16)24(33)29(4)5)14-23(32)31-15-25(2,3)17-11-28-22(10-19(17)31)34-21-9-7-6-8-18(21)26/h6-11,16,20,27H,12-15H2,1-5H3/t16-,20-/m1/s1
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n/an/a 19n/an/an/an/an/an/a



Astex Therapeutics Limited

US Patent


Assay Description
Modified SMAC peptides and compounds were tested for their ability to displace the fluorescent tracer from either XIAP, clAP-1 or clAP-2. BIR3 domain...


US Patent US9018214 (2015)


BindingDB Entry DOI: 10.7270/Q23T9FXQ
More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 2


(Homo sapiens (Human))
BDBM156040
PNG
(US9018214, 91)
Show SMILES CC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2cnc(Cc3ccccc3)cc12
Show InChI InChI=1S/C25H34N4O/c1-5-21-13-26-18(2)15-28(21)16-24(30)29-17-25(3,4)22-14-27-20(12-23(22)29)11-19-9-7-6-8-10-19/h6-10,12,14,18,21,26H,5,11,13,15-17H2,1-4H3/t18-,21+/m1/s1
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n/an/a 19n/an/an/an/an/an/a



Astex Therapeutics Limited

US Patent


Assay Description
Modified SMAC peptides and compounds were tested for their ability to displace the fluorescent tracer from either XIAP, clAP-1 or clAP-2. BIR3 domain...


US Patent US9018214 (2015)


BindingDB Entry DOI: 10.7270/Q23T9FXQ
More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 2


(Homo sapiens (Human))
BDBM156070
PNG
(US9018214, 121)
Show SMILES C[C@@H]1CN(CC(=O)N2CC(C)(C)c3cnc(Cc4ccccc4)cc23)[C@@H](CF)CN1
Show InChI InChI=1S/C24H31FN4O/c1-17-14-28(20(11-25)12-26-17)15-23(30)29-16-24(2,3)21-13-27-19(10-22(21)29)9-18-7-5-4-6-8-18/h4-8,10,13,17,20,26H,9,11-12,14-16H2,1-3H3/t17-,20+/m1/s1
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n/an/a 21n/an/an/an/an/an/a



Astex Therapeutics Limited

US Patent


Assay Description
Modified SMAC peptides and compounds were tested for their ability to displace the fluorescent tracer from either XIAP, clAP-1 or clAP-2. BIR3 domain...


US Patent US9018214 (2015)


BindingDB Entry DOI: 10.7270/Q23T9FXQ
More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 2


(Homo sapiens (Human))
BDBM156184
PNG
(US9018214, 235)
Show SMILES CC(C)CC(F)(F)c1cnc2c(c1)N(CC2(C)C)C(=O)CN1C[C@@H](C)NC[C@@H]1CN1CCOCC1
Show InChI InChI=1S/C26H41F2N5O2/c1-18(2)11-26(27,28)20-10-22-24(30-12-20)25(4,5)17-33(22)23(34)16-32-14-19(3)29-13-21(32)15-31-6-8-35-9-7-31/h10,12,18-19,21,29H,6-9,11,13-17H2,1-5H3/t19-,21-/m1/s1
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Astex Therapeutics Limited

US Patent


Assay Description
Modified SMAC peptides and compounds were tested for their ability to displace the fluorescent tracer from either XIAP, clAP-1 or clAP-2. BIR3 domain...


US Patent US9018214 (2015)


BindingDB Entry DOI: 10.7270/Q23T9FXQ
More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 2


(Homo sapiens (Human))
BDBM156175
PNG
(US9018214, 226)
Show SMILES C[C@@H]1CN(CC(=O)N2CC(C)(C)c3ncc(cc23)C(F)(F)C2CCC2)[C@@H](CN2CCCC2=O)CN1
Show InChI InChI=1S/C26H37F2N5O2/c1-17-13-32(20(12-29-17)14-31-9-5-8-22(31)34)15-23(35)33-16-25(2,3)24-21(33)10-19(11-30-24)26(27,28)18-6-4-7-18/h10-11,17-18,20,29H,4-9,12-16H2,1-3H3/t17-,20-/m1/s1
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Astex Therapeutics Limited

US Patent


Assay Description
Modified SMAC peptides and compounds were tested for their ability to displace the fluorescent tracer from either XIAP, clAP-1 or clAP-2. BIR3 domain...


US Patent US9018214 (2015)


BindingDB Entry DOI: 10.7270/Q23T9FXQ
More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 2


(Homo sapiens (Human))
BDBM156160
PNG
(US9018214, 211)
Show SMILES CC(C)C(F)(F)c1cc2N(CC(C)(C)c2cn1)C(=O)CN1C[C@@H](C)NC[C@@H]1CN1CCCC1=O
Show InChI InChI=1S/C25H37F2N5O2/c1-16(2)25(26,27)21-9-20-19(11-29-21)24(4,5)15-32(20)23(34)14-31-12-17(3)28-10-18(31)13-30-8-6-7-22(30)33/h9,11,16-18,28H,6-8,10,12-15H2,1-5H3/t17-,18-/m1/s1
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Astex Therapeutics Limited

US Patent


Assay Description
Modified SMAC peptides and compounds were tested for their ability to displace the fluorescent tracer from either XIAP, clAP-1 or clAP-2. BIR3 domain...


US Patent US9018214 (2015)


BindingDB Entry DOI: 10.7270/Q23T9FXQ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM139911
PNG
(US8895745, 354)
Show SMILES FC(F)(F)CNC(=O)Nc1cccc(c1)-c1cnc2cc(ccn12)C(=N)OC(S)=N
Show InChI InChI=1S/C18H15F3N6O2S/c19-18(20,21)9-25-17(28)26-12-3-1-2-10(6-12)13-8-24-14-7-11(4-5-27(13)14)15(22)29-16(23)30/h1-8,22H,9H2,(H2,23,30)(H2,25,26,28)
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Astex Therapeutics Limited

US Patent


Assay Description
Enzymes (from Upstate) were prepared at 2x final concentration in 1x kinase assay buffer (as described below). Enzymes were then incubated with test ...


US Patent US8895745 (2014)


BindingDB Entry DOI: 10.7270/Q2833QQC
More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 2


(Homo sapiens (Human))
BDBM156055
PNG
(US9018214, 106)
Show SMILES COC[C@H]1CN[C@H](C)CN1CC(=O)N1CC(C)(C)c2cnc(cc12)C1=CCCCC1
Show InChI InChI=1S/C24H36N4O2/c1-17-13-27(19(11-25-17)15-30-4)14-23(29)28-16-24(2,3)20-12-26-21(10-22(20)28)18-8-6-5-7-9-18/h8,10,12,17,19,25H,5-7,9,11,13-16H2,1-4H3/t17-,19-/m1/s1
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Astex Therapeutics Limited

US Patent


Assay Description
Modified SMAC peptides and compounds were tested for their ability to displace the fluorescent tracer from either XIAP, clAP-1 or clAP-2. BIR3 domain...


US Patent US9018214 (2015)


BindingDB Entry DOI: 10.7270/Q23T9FXQ
More data for this
Ligand-Target Pair
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