BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 54 hits from Astrazeneca U K Ltd   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50379165
PNG
(CHEMBL2010847)
Show SMILES CO[C@H]1CN(Cc2ccc(cc2)C(F)(F)F)CC[C@H]1N(C)C(=O)Cc1ccc(cc1)-n1cnnn1
Show InChI InChI=1S/C24H27F3N6O2/c1-31(23(34)13-17-5-9-20(10-6-17)33-16-28-29-30-33)21-11-12-32(15-22(21)35-2)14-18-3-7-19(8-4-18)24(25,26)27/h3-10,16,21-22H,11-15H2,1-2H3/t21-,22+/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.20E+3n/an/an/an/an/an/a



Astrazeneca U K Ltd

Curated by ChEMBL


Assay Description
Binding affinity to human ERG


Bioorg Med Chem Lett 21: 7310-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.033
BindingDB Entry DOI: 10.7270/Q27945PF
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50379175
PNG
(CHEMBL2010836)
Show SMILES CN(C1CCN(Cc2ccc(cc2)C(F)(F)F)CC1)C(=O)Cc1ccc(cc1)-n1cnnn1
Show InChI InChI=1S/C23H25F3N6O/c1-30(22(33)14-17-4-8-21(9-5-17)32-16-27-28-29-32)20-10-12-31(13-11-20)15-18-2-6-19(7-3-18)23(24,25)26/h2-9,16,20H,10-15H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.20E+3n/an/an/an/an/an/a



Astrazeneca U K Ltd

Curated by ChEMBL


Assay Description
Binding affinity to human ERG


Bioorg Med Chem Lett 21: 7310-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.033
BindingDB Entry DOI: 10.7270/Q27945PF
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50379170
PNG
(CHEMBL2010842)
Show SMILES CN(C1CCN(Cc2nc3cc(F)ccc3s2)CC1)C(=O)Cc1ccc(cc1)-n1cnnn1
Show InChI InChI=1S/C23H24FN7OS/c1-29(23(32)12-16-2-5-19(6-3-16)31-15-25-27-28-31)18-8-10-30(11-9-18)14-22-26-20-13-17(24)4-7-21(20)33-22/h2-7,13,15,18H,8-12,14H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.30E+3n/an/an/an/an/an/a



Astrazeneca U K Ltd

Curated by ChEMBL


Assay Description
Binding affinity to human ERG


Bioorg Med Chem Lett 21: 7310-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.033
BindingDB Entry DOI: 10.7270/Q27945PF
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50379158
PNG
(CHEMBL2010837)
Show SMILES CN(C1CCN(Cc2ccc(cc2)C(F)(F)F)CC1)C(=O)Cc1ccccc1
Show InChI InChI=1S/C22H25F3N2O/c1-26(21(28)15-17-5-3-2-4-6-17)20-11-13-27(14-12-20)16-18-7-9-19(10-8-18)22(23,24)25/h2-10,20H,11-16H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.60E+3n/an/an/an/an/an/a



Astrazeneca U K Ltd

Curated by ChEMBL


Assay Description
Binding affinity to human ERG


Bioorg Med Chem Lett 21: 7310-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.033
BindingDB Entry DOI: 10.7270/Q27945PF
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50379167
PNG
(CHEMBL2010845)
Show SMILES CN([C@@H]1CCN(Cc2ccc(cc2)C(F)(F)F)C[C@@H]1F)C(=O)Cc1ccc(cc1)-n1cnnn1
Show InChI InChI=1S/C23H24F4N6O/c1-31(22(34)12-16-4-8-19(9-5-16)33-15-28-29-30-33)21-10-11-32(14-20(21)24)13-17-2-6-18(7-3-17)23(25,26)27/h2-9,15,20-21H,10-14H2,1H3/t20-,21+/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.00E+3n/an/an/an/an/an/a



Astrazeneca U K Ltd

Curated by ChEMBL


Assay Description
Binding affinity to human ERG


Bioorg Med Chem Lett 21: 7310-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.033
BindingDB Entry DOI: 10.7270/Q27945PF
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50379166
PNG
(CHEMBL2010846)
Show SMILES CO[C@@H]1CN(Cc2ccc(cc2)C(F)(F)F)CC[C@@H]1N(C)C(=O)Cc1ccc(cc1)-n1cnnn1
Show InChI InChI=1S/C24H27F3N6O2/c1-31(23(34)13-17-5-9-20(10-6-17)33-16-28-29-30-33)21-11-12-32(15-22(21)35-2)14-18-3-7-19(8-4-18)24(25,26)27/h3-10,16,21-22H,11-15H2,1-2H3/t21-,22+/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.00E+3n/an/an/an/an/an/a



Astrazeneca U K Ltd

Curated by ChEMBL


Assay Description
Binding affinity to human ERG


Bioorg Med Chem Lett 21: 7310-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.033
BindingDB Entry DOI: 10.7270/Q27945PF
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50379177
PNG
(CHEMBL2010834)
Show SMILES CNC(=O)c1ccc(CC(=O)N(C)C2CCN(Cc3ccc(cc3)C(F)(F)F)CC2)cc1
Show InChI InChI=1S/C24H28F3N3O2/c1-28-23(32)19-7-3-17(4-8-19)15-22(31)29(2)21-11-13-30(14-12-21)16-18-5-9-20(10-6-18)24(25,26)27/h3-10,21H,11-16H2,1-2H3,(H,28,32)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.10E+3n/an/an/an/an/an/a



Astrazeneca U K Ltd

Curated by ChEMBL


Assay Description
Binding affinity to human ERG


Bioorg Med Chem Lett 21: 7310-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.033
BindingDB Entry DOI: 10.7270/Q27945PF
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50379181
PNG
(CHEMBL2010830)
Show SMILES CCN(C1CCN(Cc2ccc(cc2)C(F)(F)F)CC1)C(=O)Cc1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C24H29F3N2O3S/c1-3-29(23(30)16-18-6-10-22(11-7-18)33(2,31)32)21-12-14-28(15-13-21)17-19-4-8-20(9-5-19)24(25,26)27/h4-11,21H,3,12-17H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.50E+3n/an/an/an/an/an/a



Astrazeneca U K Ltd

Curated by ChEMBL


Assay Description
Binding affinity to human ERG


Bioorg Med Chem Lett 21: 7310-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.033
BindingDB Entry DOI: 10.7270/Q27945PF
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50379179
PNG
(CHEMBL2010832)
Show SMILES CN(C1CCN(Cc2ccc(cc2)C(F)(F)F)CC1)C(=O)Cc1ccc(cc1F)S(C)(=O)=O
Show InChI InChI=1S/C23H26F4N2O3S/c1-28(22(30)13-17-5-8-20(14-21(17)24)33(2,31)32)19-9-11-29(12-10-19)15-16-3-6-18(7-4-16)23(25,26)27/h3-8,14,19H,9-13,15H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.60E+3n/an/an/an/an/an/a



Astrazeneca U K Ltd

Curated by ChEMBL


Assay Description
Binding affinity to human ERG


Bioorg Med Chem Lett 21: 7310-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.033
BindingDB Entry DOI: 10.7270/Q27945PF
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50379172
PNG
(CHEMBL2010840)
Show SMILES CN(C1CCN(Cc2ccc(c(F)c2)C(F)(F)F)CC1)C(=O)Cc1ccc(cc1)-n1cnnn1
Show InChI InChI=1S/C23H24F4N6O/c1-31(22(34)13-16-2-5-19(6-3-16)33-15-28-29-30-33)18-8-10-32(11-9-18)14-17-4-7-20(21(24)12-17)23(25,26)27/h2-7,12,15,18H,8-11,13-14H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.80E+3n/an/an/an/an/an/a



Astrazeneca U K Ltd

Curated by ChEMBL


Assay Description
Binding affinity to human ERG


Bioorg Med Chem Lett 21: 7310-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.033
BindingDB Entry DOI: 10.7270/Q27945PF
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50379178
PNG
(CHEMBL2010833)
Show SMILES CN(C1CCN(Cc2ccc(cc2)C(F)(F)F)CC1)C(=O)Cc1ccc(c(F)c1)S(C)(=O)=O
Show InChI InChI=1S/C23H26F4N2O3S/c1-28(22(30)14-17-5-8-21(20(24)13-17)33(2,31)32)19-9-11-29(12-10-19)15-16-3-6-18(7-4-16)23(25,26)27/h3-8,13,19H,9-12,14-15H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.90E+3n/an/an/an/an/an/a



Astrazeneca U K Ltd

Curated by ChEMBL


Assay Description
Binding affinity to human ERG


Bioorg Med Chem Lett 21: 7310-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.033
BindingDB Entry DOI: 10.7270/Q27945PF
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50379180
PNG
(CHEMBL2010831)
Show SMILES CN(C1CCN(Cc2ccc(cc2)C(F)(F)F)CC1)C(=O)Cc1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C23H27F3N2O3S/c1-27(22(29)15-17-5-9-21(10-6-17)32(2,30)31)20-11-13-28(14-12-20)16-18-3-7-19(8-4-18)23(24,25)26/h3-10,20H,11-16H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.00E+3n/an/an/an/an/an/a



Astrazeneca U K Ltd

Curated by ChEMBL


Assay Description
Binding affinity to human ERG


Bioorg Med Chem Lett 21: 7310-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.033
BindingDB Entry DOI: 10.7270/Q27945PF
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50379168
PNG
(CHEMBL2010844)
Show SMILES CN([C@H]1CCN(Cc2ccc(cc2)C(F)(F)F)C[C@H]1F)C(=O)Cc1ccc(cc1)-n1cnnn1
Show InChI InChI=1S/C23H24F4N6O/c1-31(22(34)12-16-4-8-19(9-5-16)33-15-28-29-30-33)21-10-11-32(14-20(21)24)13-17-2-6-18(7-3-17)23(25,26)27/h2-9,15,20-21H,10-14H2,1H3/t20-,21+/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.60E+3n/an/an/an/an/an/a



Astrazeneca U K Ltd

Curated by ChEMBL


Assay Description
Binding affinity to human ERG


Bioorg Med Chem Lett 21: 7310-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.033
BindingDB Entry DOI: 10.7270/Q27945PF
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50379174
PNG
(CHEMBL2010838)
Show SMILES CN(C1CCN(Cc2ccc(cn2)C(F)(F)F)CC1)C(=O)Cc1ccc(cc1)-n1cnnn1
Show InChI InChI=1S/C22H24F3N7O/c1-30(21(33)12-16-2-6-20(7-3-16)32-15-27-28-29-32)19-8-10-31(11-9-19)14-18-5-4-17(13-26-18)22(23,24)25/h2-7,13,15,19H,8-12,14H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.20E+3n/an/an/an/an/an/a



Astrazeneca U K Ltd

Curated by ChEMBL


Assay Description
Binding affinity to human ERG


Bioorg Med Chem Lett 21: 7310-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.033
BindingDB Entry DOI: 10.7270/Q27945PF
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50379161
PNG
(CHEMBL2010851)
Show SMILES CN([C@@H]1CCN(Cc2ccc(cc2)C(F)(F)F)C[C@@H]1F)C(=O)Cc1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C23H26F4N2O3S/c1-28(22(30)13-16-5-9-19(10-6-16)33(2,31)32)21-11-12-29(15-20(21)24)14-17-3-7-18(8-4-17)23(25,26)27/h3-10,20-21H,11-15H2,1-2H3/t20-,21+/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.20E+3n/an/an/an/an/an/a



Astrazeneca U K Ltd

Curated by ChEMBL


Assay Description
Binding affinity to human ERG


Bioorg Med Chem Lett 21: 7310-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.033
BindingDB Entry DOI: 10.7270/Q27945PF
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50379176
PNG
(CHEMBL2010835)
Show SMILES CN(C1CCN(Cc2ccc(cc2)C(F)(F)F)CC1)C(=O)Cc1ccc(NC(C)=O)cc1
Show InChI InChI=1S/C24H28F3N3O2/c1-17(31)28-21-9-5-18(6-10-21)15-23(32)29(2)22-11-13-30(14-12-22)16-19-3-7-20(8-4-19)24(25,26)27/h3-10,22H,11-16H2,1-2H3,(H,28,31)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 4.50E+3n/an/an/an/an/an/a



Astrazeneca U K Ltd

Curated by ChEMBL


Assay Description
Binding affinity to human ERG


Bioorg Med Chem Lett 21: 7310-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.033
BindingDB Entry DOI: 10.7270/Q27945PF
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50379162
PNG
(CHEMBL2010850)
Show SMILES CN([C@@H]1CCN(Cc2nc3cc(F)ccc3s2)C[C@@H]1F)C(=O)Cc1ccc(cc1)-n1cnnn1
Show InChI InChI=1S/C23H23F2N7OS/c1-30(23(33)10-15-2-5-17(6-3-15)32-14-26-28-29-32)20-8-9-31(12-18(20)25)13-22-27-19-11-16(24)4-7-21(19)34-22/h2-7,11,14,18,20H,8-10,12-13H2,1H3/t18-,20+/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.70E+3n/an/an/an/an/an/a



Astrazeneca U K Ltd

Curated by ChEMBL


Assay Description
Binding affinity to human ERG


Bioorg Med Chem Lett 21: 7310-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.033
BindingDB Entry DOI: 10.7270/Q27945PF
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50379171
PNG
(CHEMBL2010841)
Show SMILES CN(C1CCN(Cc2ccc(cc2)-c2noc(C)n2)CC1)C(=O)Cc1ccc(cc1)-n1cnnn1
Show InChI InChI=1S/C25H28N8O2/c1-18-27-25(28-35-18)21-7-3-20(4-8-21)16-32-13-11-22(12-14-32)31(2)24(34)15-19-5-9-23(10-6-19)33-17-26-29-30-33/h3-10,17,22H,11-16H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 6.50E+3n/an/an/an/an/an/a



Astrazeneca U K Ltd

Curated by ChEMBL


Assay Description
Binding affinity to human ERG


Bioorg Med Chem Lett 21: 7310-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.033
BindingDB Entry DOI: 10.7270/Q27945PF
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50379159
PNG
(CHEMBL2010853)
Show SMILES CN([C@@H]1CCN(Cc2nc3cc(F)ccc3s2)C[C@@H]1F)C(=O)Cc1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C23H25F2N3O3S2/c1-27(23(29)11-15-3-6-17(7-4-15)33(2,30)31)20-9-10-28(13-18(20)25)14-22-26-19-12-16(24)5-8-21(19)32-22/h3-8,12,18,20H,9-11,13-14H2,1-2H3/t18-,20+/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 7.00E+3n/an/an/an/an/an/a



Astrazeneca U K Ltd

Curated by ChEMBL


Assay Description
Binding affinity to human ERG


Bioorg Med Chem Lett 21: 7310-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.033
BindingDB Entry DOI: 10.7270/Q27945PF
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50379169
PNG
(CHEMBL2010843)
Show SMILES CN(C1CCN(Cc2nc3CCCCc3s2)CC1)C(=O)Cc1ccc(cc1)-n1cnnn1
Show InChI InChI=1S/C23H29N7OS/c1-28(23(31)14-17-6-8-19(9-7-17)30-16-24-26-27-30)18-10-12-29(13-11-18)15-22-25-20-4-2-3-5-21(20)32-22/h6-9,16,18H,2-5,10-15H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 7.60E+3n/an/an/an/an/an/a



Astrazeneca U K Ltd

Curated by ChEMBL


Assay Description
Binding affinity to human ERG


Bioorg Med Chem Lett 21: 7310-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.033
BindingDB Entry DOI: 10.7270/Q27945PF
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50379164
PNG
(CHEMBL2010848)
Show SMILES CN([C@@H]1CCN(Cc2ccc(cn2)C(F)(F)F)C[C@@H]1F)C(=O)Cc1ccc(cc1)-n1cnnn1
Show InChI InChI=1S/C22H23F4N7O/c1-31(21(34)10-15-2-6-18(7-3-15)33-14-28-29-30-33)20-8-9-32(13-19(20)23)12-17-5-4-16(11-27-17)22(24,25)26/h2-7,11,14,19-20H,8-10,12-13H2,1H3/t19-,20+/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.00E+4n/an/an/an/an/an/a



Astrazeneca U K Ltd

Curated by ChEMBL


Assay Description
Binding affinity to human ERG


Bioorg Med Chem Lett 21: 7310-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.033
BindingDB Entry DOI: 10.7270/Q27945PF
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50379173
PNG
(CHEMBL2010839)
Show SMILES CN(C1CCN(Cc2ccc(nc2)C(F)(F)F)CC1)C(=O)Cc1ccc(cc1)-n1cnnn1
Show InChI InChI=1S/C22H24F3N7O/c1-30(21(33)12-16-2-5-19(6-3-16)32-15-27-28-29-32)18-8-10-31(11-9-18)14-17-4-7-20(26-13-17)22(23,24)25/h2-7,13,15,18H,8-12,14H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.30E+4n/an/an/an/an/an/a



Astrazeneca U K Ltd

Curated by ChEMBL


Assay Description
Binding affinity to human ERG


Bioorg Med Chem Lett 21: 7310-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.033
BindingDB Entry DOI: 10.7270/Q27945PF
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50379163
PNG
(CHEMBL2010849)
Show SMILES CN([C@@H]1CCN(Cc2ccc(nc2)C(F)(F)F)C[C@@H]1F)C(=O)Cc1ccc(cc1)-n1cnnn1
Show InChI InChI=1S/C22H23F4N7O/c1-31(21(34)10-15-2-5-17(6-3-15)33-14-28-29-30-33)19-8-9-32(13-18(19)23)12-16-4-7-20(27-11-16)22(24,25)26/h2-7,11,14,18-19H,8-10,12-13H2,1H3/t18-,19+/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.50E+4n/an/an/an/an/an/a



Astrazeneca U K Ltd

Curated by ChEMBL


Assay Description
Binding affinity to human ERG


Bioorg Med Chem Lett 21: 7310-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.033
BindingDB Entry DOI: 10.7270/Q27945PF
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM50379160
PNG
(CHEMBL2010852)
Show SMILES CN([C@@H]1CCN(Cc2nc3ccccc3s2)C[C@@H]1F)C(=O)Cc1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C23H26FN3O3S2/c1-26(23(28)13-16-7-9-17(10-8-16)32(2,29)30)20-11-12-27(14-18(20)24)15-22-25-19-5-3-4-6-21(19)31-22/h3-10,18,20H,11-15H2,1-2H3/t18-,20+/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.60E+4n/an/an/an/an/an/a



Astrazeneca U K Ltd

Curated by ChEMBL


Assay Description
Binding affinity to human ERG


Bioorg Med Chem Lett 21: 7310-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.033
BindingDB Entry DOI: 10.7270/Q27945PF
More data for this
Ligand-Target Pair
Cytochrome P450 2C19


(Homo sapiens (human))
BDBM50379175
PNG
(CHEMBL2010836)
Show SMILES CN(C1CCN(Cc2ccc(cc2)C(F)(F)F)CC1)C(=O)Cc1ccc(cc1)-n1cnnn1
Show InChI InChI=1S/C23H25F3N6O/c1-30(22(33)14-17-4-8-21(9-5-17)32-16-27-28-29-32)20-10-12-31(13-11-20)15-18-2-6-19(7-3-18)23(24,25)26/h2-9,16,20H,10-15H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>2.50E+4n/an/an/an/an/an/a



Astrazeneca U K Ltd

Curated by ChEMBL


Assay Description
Inhibition of CYP2C19 by HTRF assay


Bioorg Med Chem Lett 21: 7310-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.033
BindingDB Entry DOI: 10.7270/Q27945PF
More data for this
Ligand-Target Pair
Cytochrome P450 2D6 (2D6)


(Homo sapiens (Human))
BDBM50379175
PNG
(CHEMBL2010836)
Show SMILES CN(C1CCN(Cc2ccc(cc2)C(F)(F)F)CC1)C(=O)Cc1ccc(cc1)-n1cnnn1
Show InChI InChI=1S/C23H25F3N6O/c1-30(22(33)14-17-4-8-21(9-5-17)32-16-27-28-29-32)20-10-12-31(13-11-20)15-18-2-6-19(7-3-18)23(24,25)26/h2-9,16,20H,10-15H2,1H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>2.50E+4n/an/an/an/an/an/a



Astrazeneca U K Ltd

Curated by ChEMBL


Assay Description
Inhibition of CYP2D6 by HTRF assay


Bioorg Med Chem Lett 21: 7310-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.033
BindingDB Entry DOI: 10.7270/Q27945PF
More data for this
Ligand-Target Pair
Cytochrome P450 3A


(Homo sapiens (human))
BDBM50379175
PNG
(CHEMBL2010836)
Show SMILES CN(C1CCN(Cc2ccc(cc2)C(F)(F)F)CC1)C(=O)Cc1ccc(cc1)-n1cnnn1
Show InChI InChI=1S/C23H25F3N6O/c1-30(22(33)14-17-4-8-21(9-5-17)32-16-27-28-29-32)20-10-12-31(13-11-20)15-18-2-6-19(7-3-18)23(24,25)26/h2-9,16,20H,10-15H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>2.50E+4n/an/an/an/an/an/a



Astrazeneca U K Ltd

Curated by ChEMBL


Assay Description
Inhibition of CYP3A4 by HTRF assay


Bioorg Med Chem Lett 21: 7310-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.033
BindingDB Entry DOI: 10.7270/Q27945PF
More data for this
Ligand-Target Pair
Cytochrome P450 1A


(Homo sapiens (human))
BDBM50379175
PNG
(CHEMBL2010836)
Show SMILES CN(C1CCN(Cc2ccc(cc2)C(F)(F)F)CC1)C(=O)Cc1ccc(cc1)-n1cnnn1
Show InChI InChI=1S/C23H25F3N6O/c1-30(22(33)14-17-4-8-21(9-5-17)32-16-27-28-29-32)20-10-12-31(13-11-20)15-18-2-6-19(7-3-18)23(24,25)26/h2-9,16,20H,10-15H2,1H3
PDB
MMDB

Reactome pathway
KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>2.50E+4n/an/an/an/an/an/a



Astrazeneca U K Ltd

Curated by ChEMBL


Assay Description
Inhibition of CYP1A2 by HTRF assay


Bioorg Med Chem Lett 21: 7310-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.033
BindingDB Entry DOI: 10.7270/Q27945PF
More data for this
Ligand-Target Pair
Cytochrome P450 2C9


(Homo sapiens (human))
BDBM50379175
PNG
(CHEMBL2010836)
Show SMILES CN(C1CCN(Cc2ccc(cc2)C(F)(F)F)CC1)C(=O)Cc1ccc(cc1)-n1cnnn1
Show InChI InChI=1S/C23H25F3N6O/c1-30(22(33)14-17-4-8-21(9-5-17)32-16-27-28-29-32)20-10-12-31(13-11-20)15-18-2-6-19(7-3-18)23(24,25)26/h2-9,16,20H,10-15H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>2.50E+4n/an/an/an/an/an/a



Astrazeneca U K Ltd

Curated by ChEMBL


Assay Description
Inhibition of CYP2C9 by HTRF assay


Bioorg Med Chem Lett 21: 7310-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.033
BindingDB Entry DOI: 10.7270/Q27945PF
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50379164
PNG
(CHEMBL2010848)
Show SMILES CN([C@@H]1CCN(Cc2ccc(cn2)C(F)(F)F)C[C@@H]1F)C(=O)Cc1ccc(cc1)-n1cnnn1
Show InChI InChI=1S/C22H23F4N7O/c1-31(21(34)10-15-2-6-18(7-3-15)33-14-28-29-30-33)20-8-9-32(13-19(20)23)12-17-5-4-16(11-27-17)22(24,25)26/h2-7,11,14,19-20H,8-10,12-13H2,1H3/t19-,20+/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 140n/an/an/an/a



Astrazeneca U K Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in HEK293 cells assessed as cAMP accumulation after 45 mins by fluorescence assay


Bioorg Med Chem Lett 21: 7310-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.033
BindingDB Entry DOI: 10.7270/Q27945PF
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50379163
PNG
(CHEMBL2010849)
Show SMILES CN([C@@H]1CCN(Cc2ccc(nc2)C(F)(F)F)C[C@@H]1F)C(=O)Cc1ccc(cc1)-n1cnnn1
Show InChI InChI=1S/C22H23F4N7O/c1-31(21(34)10-15-2-5-17(6-3-15)33-14-28-29-30-33)19-8-9-32(13-18(19)23)12-16-4-7-20(27-11-16)22(24,25)26/h2-7,11,14,18-19H,8-10,12-13H2,1H3/t18-,19+/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 485n/an/an/an/a



Astrazeneca U K Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in HEK293 cells assessed as cAMP accumulation after 45 mins by fluorescence assay


Bioorg Med Chem Lett 21: 7310-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.033
BindingDB Entry DOI: 10.7270/Q27945PF
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50379162
PNG
(CHEMBL2010850)
Show SMILES CN([C@@H]1CCN(Cc2nc3cc(F)ccc3s2)C[C@@H]1F)C(=O)Cc1ccc(cc1)-n1cnnn1
Show InChI InChI=1S/C23H23F2N7OS/c1-30(23(33)10-15-2-5-17(6-3-15)32-14-26-28-29-32)20-8-9-31(12-18(20)25)13-22-27-19-11-16(24)4-7-21(19)34-22/h2-7,11,14,18,20H,8-10,12-13H2,1H3/t18-,20+/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 12n/an/an/an/a



Astrazeneca U K Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in HEK293 cells assessed as cAMP accumulation after 45 mins by fluorescence assay


Bioorg Med Chem Lett 21: 7310-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.033
BindingDB Entry DOI: 10.7270/Q27945PF
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50379161
PNG
(CHEMBL2010851)
Show SMILES CN([C@@H]1CCN(Cc2ccc(cc2)C(F)(F)F)C[C@@H]1F)C(=O)Cc1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C23H26F4N2O3S/c1-28(22(30)13-16-5-9-19(10-6-16)33(2,31)32)21-11-12-29(15-20(21)24)14-17-3-7-18(8-4-17)23(25,26)27/h3-10,20-21H,11-15H2,1-2H3/t20-,21+/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 4n/an/an/an/a



Astrazeneca U K Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in HEK293 cells assessed as cAMP accumulation after 45 mins by fluorescence assay


Bioorg Med Chem Lett 21: 7310-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.033
BindingDB Entry DOI: 10.7270/Q27945PF
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50379175
PNG
(CHEMBL2010836)
Show SMILES CN(C1CCN(Cc2ccc(cc2)C(F)(F)F)CC1)C(=O)Cc1ccc(cc1)-n1cnnn1
Show InChI InChI=1S/C23H25F3N6O/c1-30(22(33)14-17-4-8-21(9-5-17)32-16-27-28-29-32)20-10-12-31(13-11-20)15-18-2-6-19(7-3-18)23(24,25)26/h2-9,16,20H,10-15H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 147n/an/an/an/a



Astrazeneca U K Ltd

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 by cAMP assay


Bioorg Med Chem Lett 21: 7310-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.033
BindingDB Entry DOI: 10.7270/Q27945PF
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50379160
PNG
(CHEMBL2010852)
Show SMILES CN([C@@H]1CCN(Cc2nc3ccccc3s2)C[C@@H]1F)C(=O)Cc1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C23H26FN3O3S2/c1-26(23(28)13-16-7-9-17(10-8-16)32(2,29)30)20-11-12-27(14-18(20)24)15-22-25-19-5-3-4-6-21(19)31-22/h3-10,18,20H,11-15H2,1-2H3/t18-,20+/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 24n/an/an/an/a



Astrazeneca U K Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in HEK293 cells assessed as cAMP accumulation after 45 mins by fluorescence assay


Bioorg Med Chem Lett 21: 7310-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.033
BindingDB Entry DOI: 10.7270/Q27945PF
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50379159
PNG
(CHEMBL2010853)
Show SMILES CN([C@@H]1CCN(Cc2nc3cc(F)ccc3s2)C[C@@H]1F)C(=O)Cc1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C23H25F2N3O3S2/c1-27(23(29)11-15-3-6-17(7-4-15)33(2,30)31)20-9-10-28(13-18(20)25)14-22-26-19-12-16(24)5-8-21(19)32-22/h3-8,12,18,20H,9-11,13-14H2,1-2H3/t18-,20+/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 18n/an/an/an/a



Astrazeneca U K Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in HEK293 cells assessed as cAMP accumulation after 45 mins by fluorescence assay


Bioorg Med Chem Lett 21: 7310-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.033
BindingDB Entry DOI: 10.7270/Q27945PF
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50379158
PNG
(CHEMBL2010837)
Show SMILES CN(C1CCN(Cc2ccc(cc2)C(F)(F)F)CC1)C(=O)Cc1ccccc1
Show InChI InChI=1S/C22H25F3N2O/c1-26(21(28)15-17-5-3-2-4-6-17)20-11-13-27(14-12-20)16-18-7-9-19(10-8-18)22(23,24)25/h2-10,20H,11-16H2,1H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a>3.00E+4n/an/an/an/a



Astrazeneca U K Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in HEK293 cells assessed as cAMP accumulation after 45 mins by fluorescence assay


Bioorg Med Chem Lett 21: 7310-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.033
BindingDB Entry DOI: 10.7270/Q27945PF
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50379165
PNG
(CHEMBL2010847)
Show SMILES CO[C@H]1CN(Cc2ccc(cc2)C(F)(F)F)CC[C@H]1N(C)C(=O)Cc1ccc(cc1)-n1cnnn1
Show InChI InChI=1S/C24H27F3N6O2/c1-31(23(34)13-17-5-9-20(10-6-17)33-16-28-29-30-33)21-11-12-32(15-22(21)35-2)14-18-3-7-19(8-4-18)24(25,26)27/h3-10,16,21-22H,11-15H2,1-2H3/t21-,22+/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 172n/an/an/an/a



Astrazeneca U K Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in HEK293 cells assessed as cAMP accumulation after 45 mins by fluorescence assay


Bioorg Med Chem Lett 21: 7310-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.033
BindingDB Entry DOI: 10.7270/Q27945PF
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50379166
PNG
(CHEMBL2010846)
Show SMILES CO[C@@H]1CN(Cc2ccc(cc2)C(F)(F)F)CC[C@@H]1N(C)C(=O)Cc1ccc(cc1)-n1cnnn1
Show InChI InChI=1S/C24H27F3N6O2/c1-31(23(34)13-17-5-9-20(10-6-17)33-16-28-29-30-33)21-11-12-32(15-22(21)35-2)14-18-3-7-19(8-4-18)24(25,26)27/h3-10,16,21-22H,11-15H2,1-2H3/t21-,22+/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 29n/an/an/an/a



Astrazeneca U K Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in HEK293 cells assessed as cAMP accumulation after 45 mins by fluorescence assay


Bioorg Med Chem Lett 21: 7310-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.033
BindingDB Entry DOI: 10.7270/Q27945PF
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50379167
PNG
(CHEMBL2010845)
Show SMILES CN([C@@H]1CCN(Cc2ccc(cc2)C(F)(F)F)C[C@@H]1F)C(=O)Cc1ccc(cc1)-n1cnnn1
Show InChI InChI=1S/C23H24F4N6O/c1-31(22(34)12-16-4-8-19(9-5-16)33-15-28-29-30-33)21-10-11-32(14-20(21)24)13-17-2-6-18(7-3-17)23(25,26)27/h2-9,15,20-21H,10-14H2,1H3/t20-,21+/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 7n/an/an/an/a



Astrazeneca U K Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in HEK293 cells assessed as cAMP accumulation after 45 mins by fluorescence assay


Bioorg Med Chem Lett 21: 7310-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.033
BindingDB Entry DOI: 10.7270/Q27945PF
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50379168
PNG
(CHEMBL2010844)
Show SMILES CN([C@H]1CCN(Cc2ccc(cc2)C(F)(F)F)C[C@H]1F)C(=O)Cc1ccc(cc1)-n1cnnn1
Show InChI InChI=1S/C23H24F4N6O/c1-31(22(34)12-16-4-8-19(9-5-16)33-15-28-29-30-33)21-10-11-32(14-20(21)24)13-17-2-6-18(7-3-17)23(25,26)27/h2-9,15,20-21H,10-14H2,1H3/t20-,21+/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 29n/an/an/an/a



Astrazeneca U K Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in HEK293 cells assessed as cAMP accumulation after 45 mins by fluorescence assay


Bioorg Med Chem Lett 21: 7310-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.033
BindingDB Entry DOI: 10.7270/Q27945PF
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50379169
PNG
(CHEMBL2010843)
Show SMILES CN(C1CCN(Cc2nc3CCCCc3s2)CC1)C(=O)Cc1ccc(cc1)-n1cnnn1
Show InChI InChI=1S/C23H29N7OS/c1-28(23(31)14-17-6-8-19(9-7-17)30-16-24-26-27-30)18-10-12-29(13-11-18)15-22-25-20-4-2-3-5-21(20)32-22/h6-9,16,18H,2-5,10-15H2,1H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 396n/an/an/an/a



Astrazeneca U K Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in HEK293 cells assessed as cAMP accumulation after 45 mins by fluorescence assay


Bioorg Med Chem Lett 21: 7310-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.033
BindingDB Entry DOI: 10.7270/Q27945PF
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50379181
PNG
(CHEMBL2010830)
Show SMILES CCN(C1CCN(Cc2ccc(cc2)C(F)(F)F)CC1)C(=O)Cc1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C24H29F3N2O3S/c1-3-29(23(30)16-18-6-10-22(11-7-18)33(2,31)32)21-12-14-28(15-13-21)17-19-4-8-20(9-5-19)24(25,26)27/h4-11,21H,3,12-17H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 538n/an/an/an/a



Astrazeneca U K Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in HEK293 cells assessed as cAMP accumulation after 45 mins by fluorescence assay


Bioorg Med Chem Lett 21: 7310-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.033
BindingDB Entry DOI: 10.7270/Q27945PF
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50379180
PNG
(CHEMBL2010831)
Show SMILES CN(C1CCN(Cc2ccc(cc2)C(F)(F)F)CC1)C(=O)Cc1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C23H27F3N2O3S/c1-27(22(29)15-17-5-9-21(10-6-17)32(2,30)31)20-11-13-28(14-12-20)16-18-3-7-19(8-4-18)23(24,25)26/h3-10,20H,11-16H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 456n/an/an/an/a



Astrazeneca U K Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in HEK293 cells assessed as cAMP accumulation after 45 mins by fluorescence assay


Bioorg Med Chem Lett 21: 7310-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.033
BindingDB Entry DOI: 10.7270/Q27945PF
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50379179
PNG
(CHEMBL2010832)
Show SMILES CN(C1CCN(Cc2ccc(cc2)C(F)(F)F)CC1)C(=O)Cc1ccc(cc1F)S(C)(=O)=O
Show InChI InChI=1S/C23H26F4N2O3S/c1-28(22(30)13-17-5-8-20(14-21(17)24)33(2,31)32)19-9-11-29(12-10-19)15-16-3-6-18(7-4-16)23(25,26)27/h3-8,14,19H,9-13,15H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 122n/an/an/an/a



Astrazeneca U K Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in HEK293 cells assessed as cAMP accumulation after 45 mins by fluorescence assay


Bioorg Med Chem Lett 21: 7310-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.033
BindingDB Entry DOI: 10.7270/Q27945PF
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50379178
PNG
(CHEMBL2010833)
Show SMILES CN(C1CCN(Cc2ccc(cc2)C(F)(F)F)CC1)C(=O)Cc1ccc(c(F)c1)S(C)(=O)=O
Show InChI InChI=1S/C23H26F4N2O3S/c1-28(22(30)14-17-5-8-21(20(24)13-17)33(2,31)32)19-9-11-29(12-10-19)15-16-3-6-18(7-4-16)23(25,26)27/h3-8,13,19H,9-12,14-15H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 131n/an/an/an/a



Astrazeneca U K Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in HEK293 cells assessed as cAMP accumulation after 45 mins by fluorescence assay


Bioorg Med Chem Lett 21: 7310-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.033
BindingDB Entry DOI: 10.7270/Q27945PF
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50379177
PNG
(CHEMBL2010834)
Show SMILES CNC(=O)c1ccc(CC(=O)N(C)C2CCN(Cc3ccc(cc3)C(F)(F)F)CC2)cc1
Show InChI InChI=1S/C24H28F3N3O2/c1-28-23(32)19-7-3-17(4-8-19)15-22(31)29(2)21-11-13-30(14-12-21)16-18-5-9-20(10-6-18)24(25,26)27/h3-10,21H,11-16H2,1-2H3,(H,28,32)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 489n/an/an/an/a



Astrazeneca U K Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in HEK293 cells assessed as cAMP accumulation after 45 mins by fluorescence assay


Bioorg Med Chem Lett 21: 7310-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.033
BindingDB Entry DOI: 10.7270/Q27945PF
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50379176
PNG
(CHEMBL2010835)
Show SMILES CN(C1CCN(Cc2ccc(cc2)C(F)(F)F)CC1)C(=O)Cc1ccc(NC(C)=O)cc1
Show InChI InChI=1S/C24H28F3N3O2/c1-17(31)28-21-9-5-18(6-10-21)15-23(32)29(2)22-11-13-30(14-12-22)16-19-3-7-20(8-4-19)24(25,26)27/h3-10,22H,11-16H2,1-2H3,(H,28,31)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 535n/an/an/an/a



Astrazeneca U K Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in HEK293 cells assessed as cAMP accumulation after 45 mins by fluorescence assay


Bioorg Med Chem Lett 21: 7310-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.033
BindingDB Entry DOI: 10.7270/Q27945PF
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50379175
PNG
(CHEMBL2010836)
Show SMILES CN(C1CCN(Cc2ccc(cc2)C(F)(F)F)CC1)C(=O)Cc1ccc(cc1)-n1cnnn1
Show InChI InChI=1S/C23H25F3N6O/c1-30(22(33)14-17-4-8-21(9-5-17)32-16-27-28-29-32)20-10-12-31(13-11-20)15-18-2-6-19(7-3-18)23(24,25)26/h2-9,16,20H,10-15H2,1H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 74n/an/an/an/a



Astrazeneca U K Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in HEK293 cells assessed as cAMP accumulation after 45 mins by fluorescence assay


Bioorg Med Chem Lett 21: 7310-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.033
BindingDB Entry DOI: 10.7270/Q27945PF
More data for this
Ligand-Target Pair
G-protein coupled receptor 119 (GPR119)


(Homo sapiens (Human))
BDBM50379174
PNG
(CHEMBL2010838)
Show SMILES CN(C1CCN(Cc2ccc(cn2)C(F)(F)F)CC1)C(=O)Cc1ccc(cc1)-n1cnnn1
Show InChI InChI=1S/C22H24F3N7O/c1-30(21(33)12-16-2-6-20(7-3-16)32-15-27-28-29-32)19-8-10-31(11-9-19)14-18-5-4-17(13-26-18)22(23,24)25/h2-7,13,15,19H,8-12,14H2,1H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 1.35E+3n/an/an/an/a



Astrazeneca U K Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in HEK293 cells assessed as cAMP accumulation after 45 mins by fluorescence assay


Bioorg Med Chem Lett 21: 7310-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.10.033
BindingDB Entry DOI: 10.7270/Q27945PF
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 54 total )  |  Next  |  Last  >>
Jump to: