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Compile Data Set for Download or QSAR

Found 36 hits from Asubio Pharma Co., Ltd.   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cPLA2 C2


(Homo sapiens (human))
BDBM50226792
PNG
(4-(3-(1-benzhydryl-5-chloro-2-(2-((3,4-dichlorophe...)
Show SMILES OC(=O)c1ccc(CCCc2c(CCNS(=O)(=O)Cc3ccc(Cl)c(Cl)c3)n(C(c3ccccc3)c3ccccc3)c3ccc(Cl)cc23)cc1
Show InChI InChI=1S/C40H35Cl3N2O4S/c41-32-19-21-37-34(25-32)33(13-7-8-27-14-17-31(18-15-27)40(46)47)38(22-23-44-50(48,49)26-28-16-20-35(42)36(43)24-28)45(37)39(29-9-3-1-4-10-29)30-11-5-2-6-12-30/h1-6,9-12,14-21,24-25,39,44H,7-8,13,22-23,26H2,(H,46,47)
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n/an/a 0.540n/an/an/an/an/an/a



Asubio Pharma Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cPLA2alpha isolated from human U937 cell cytoplasm assessed as suppression of [14C]arachidonic acid release from L-alpha-1-palmitoyl-2-...


J Med Chem 57: 7244-62 (2014)


Article DOI: 10.1021/jm500494y
BindingDB Entry DOI: 10.7270/Q2F47QSP
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (human))
BDBM50056707
PNG
(CHEMBL3326971)
Show SMILES CCCOc1ccc(cc1)-n1cc(CCc2ccccc2)c2cc(CCC(O)=O)ccc12
Show InChI InChI=1S/C28H29NO3/c1-2-18-32-25-14-12-24(13-15-25)29-20-23(11-8-21-6-4-3-5-7-21)26-19-22(9-16-27(26)29)10-17-28(30)31/h3-7,9,12-16,19-20H,2,8,10-11,17-18H2,1H3,(H,30,31)
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n/an/a 7n/an/an/an/an/an/a



Asubio Pharma Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cPLA2alpha isolated from human U937 cell cytoplasm assessed as suppression of [14C]arachidonic acid release from L-alpha-1-palmitoyl-2-...


J Med Chem 57: 7244-62 (2014)


Article DOI: 10.1021/jm500494y
BindingDB Entry DOI: 10.7270/Q2F47QSP
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (human))
BDBM50056741
PNG
(CHEMBL3327088)
Show SMILES CC(C)Oc1ccc(cc1)-n1cc(CCc2ccccc2)c2cc(CCC(O)=O)ccc12
Show InChI InChI=1S/C28H29NO3/c1-20(2)32-25-14-12-24(13-15-25)29-19-23(11-8-21-6-4-3-5-7-21)26-18-22(9-16-27(26)29)10-17-28(30)31/h3-7,9,12-16,18-20H,8,10-11,17H2,1-2H3,(H,30,31)
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n/an/a 7n/an/an/an/an/an/a



Asubio Pharma Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cPLA2alpha isolated from human U937 cell cytoplasm assessed as suppression of [14C]arachidonic acid release from L-alpha-1-palmitoyl-2-...


J Med Chem 57: 7244-62 (2014)


Article DOI: 10.1021/jm500494y
BindingDB Entry DOI: 10.7270/Q2F47QSP
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (human))
BDBM50056712
PNG
(CHEMBL3326966)
Show SMILES OC(=O)CCc1ccc2n(cc(CCc3ccccc3)c2c1)-c1ccc(O)cc1
Show InChI InChI=1S/C25H23NO3/c27-22-12-10-21(11-13-22)26-17-20(9-6-18-4-2-1-3-5-18)23-16-19(7-14-24(23)26)8-15-25(28)29/h1-5,7,10-14,16-17,27H,6,8-9,15H2,(H,28,29)
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n/an/a 11n/an/an/an/an/an/a



Asubio Pharma Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cPLA2alpha isolated from human U937 cell cytoplasm assessed as suppression of [14C]arachidonic acid release from L-alpha-1-palmitoyl-2-...


J Med Chem 57: 7244-62 (2014)


Article DOI: 10.1021/jm500494y
BindingDB Entry DOI: 10.7270/Q2F47QSP
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (human))
BDBM50056740
PNG
(CHEMBL3327089)
Show SMILES OCCOc1ccc(cc1)-n1cc(CCc2ccccc2)c2cc(CCC(O)=O)ccc12
Show InChI InChI=1S/C27H27NO4/c29-16-17-32-24-12-10-23(11-13-24)28-19-22(9-6-20-4-2-1-3-5-20)25-18-21(7-14-26(25)28)8-15-27(30)31/h1-5,7,10-14,18-19,29H,6,8-9,15-17H2,(H,30,31)
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n/an/a 14n/an/an/an/an/an/a



Asubio Pharma Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cPLA2alpha isolated from human U937 cell cytoplasm assessed as suppression of [14C]arachidonic acid release from L-alpha-1-palmitoyl-2-...


J Med Chem 57: 7244-62 (2014)


Article DOI: 10.1021/jm500494y
BindingDB Entry DOI: 10.7270/Q2F47QSP
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (human))
BDBM50056708
PNG
(CHEMBL3326970)
Show SMILES CCOc1ccc(cc1)-n1cc(CCc2ccccc2)c2cc(CCC(O)=O)ccc12
Show InChI InChI=1S/C27H27NO3/c1-2-31-24-14-12-23(13-15-24)28-19-22(11-8-20-6-4-3-5-7-20)25-18-21(9-16-26(25)28)10-17-27(29)30/h3-7,9,12-16,18-19H,2,8,10-11,17H2,1H3,(H,29,30)
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n/an/a 15n/an/an/an/an/an/a



Asubio Pharma Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cPLA2alpha isolated from human U937 cell cytoplasm assessed as suppression of [14C]arachidonic acid release from L-alpha-1-palmitoyl-2-...


J Med Chem 57: 7244-62 (2014)


Article DOI: 10.1021/jm500494y
BindingDB Entry DOI: 10.7270/Q2F47QSP
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (human))
BDBM50056737
PNG
(CHEMBL3327092)
Show SMILES OC(=O)CCc1ccc2n(cc(CCc3ccccc3)c2c1)-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C31H27NO3/c33-31(34)20-13-24-12-19-30-29(21-24)25(14-11-23-7-3-1-4-8-23)22-32(30)26-15-17-28(18-16-26)35-27-9-5-2-6-10-27/h1-10,12,15-19,21-22H,11,13-14,20H2,(H,33,34)
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n/an/a 20n/an/an/an/an/an/a



Asubio Pharma Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cPLA2alpha isolated from human U937 cell cytoplasm assessed as suppression of [14C]arachidonic acid release from L-alpha-1-palmitoyl-2-...


J Med Chem 57: 7244-62 (2014)


Article DOI: 10.1021/jm500494y
BindingDB Entry DOI: 10.7270/Q2F47QSP
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (human))
BDBM50056709
PNG
(CHEMBL3326969)
Show SMILES COc1ccc(cc1)-n1cc(CCc2ccccc2)c2cc(CCC(O)=O)ccc12
Show InChI InChI=1S/C26H25NO3/c1-30-23-13-11-22(12-14-23)27-18-21(10-7-19-5-3-2-4-6-19)24-17-20(8-15-25(24)27)9-16-26(28)29/h2-6,8,11-15,17-18H,7,9-10,16H2,1H3,(H,28,29)
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n/an/a 26n/an/an/an/an/an/a



Asubio Pharma Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cPLA2alpha isolated from human U937 cell cytoplasm assessed as suppression of [14C]arachidonic acid release from L-alpha-1-palmitoyl-2-...


J Med Chem 57: 7244-62 (2014)


Article DOI: 10.1021/jm500494y
BindingDB Entry DOI: 10.7270/Q2F47QSP
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (human))
BDBM50056739
PNG
(CHEMBL3327090)
Show SMILES OC(=O)CCc1ccc2n(cc(CCc3ccccc3)c2c1)-c1ccc(OC(F)F)cc1
Show InChI InChI=1S/C26H23F2NO3/c27-26(28)32-22-12-10-21(11-13-22)29-17-20(9-6-18-4-2-1-3-5-18)23-16-19(7-14-24(23)29)8-15-25(30)31/h1-5,7,10-14,16-17,26H,6,8-9,15H2,(H,30,31)
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n/an/a 28n/an/an/an/an/an/a



Asubio Pharma Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cPLA2alpha isolated from human U937 cell cytoplasm assessed as suppression of [14C]arachidonic acid release from L-alpha-1-palmitoyl-2-...


J Med Chem 57: 7244-62 (2014)


Article DOI: 10.1021/jm500494y
BindingDB Entry DOI: 10.7270/Q2F47QSP
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (human))
BDBM50056732
PNG
(CHEMBL3327094)
Show SMILES OC(=O)CCc1ccc2n(cc(CCc3ccccc3)c2c1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C25H22ClNO2/c26-21-10-12-22(13-11-21)27-17-20(9-6-18-4-2-1-3-5-18)23-16-19(7-14-24(23)27)8-15-25(28)29/h1-5,7,10-14,16-17H,6,8-9,15H2,(H,28,29)
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n/an/a 36n/an/an/an/an/an/a



Asubio Pharma Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cPLA2alpha isolated from human U937 cell cytoplasm assessed as suppression of [14C]arachidonic acid release from L-alpha-1-palmitoyl-2-...


J Med Chem 57: 7244-62 (2014)


Article DOI: 10.1021/jm500494y
BindingDB Entry DOI: 10.7270/Q2F47QSP
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (human))
BDBM50056733
PNG
(CHEMBL3327095)
Show SMILES OC(=O)CCc1ccc2n(cc(CCc3ccccc3)c2c1)-c1ccc(F)cc1
Show InChI InChI=1S/C25H22FNO2/c26-21-10-12-22(13-11-21)27-17-20(9-6-18-4-2-1-3-5-18)23-16-19(7-14-24(23)27)8-15-25(28)29/h1-5,7,10-14,16-17H,6,8-9,15H2,(H,28,29)
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n/an/a 58n/an/an/an/an/an/a



Asubio Pharma Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cPLA2alpha isolated from human U937 cell cytoplasm assessed as suppression of [14C]arachidonic acid release from L-alpha-1-palmitoyl-2-...


J Med Chem 57: 7244-62 (2014)


Article DOI: 10.1021/jm500494y
BindingDB Entry DOI: 10.7270/Q2F47QSP
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (human))
BDBM50056730
PNG
(CHEMBL3326948)
Show SMILES OC(=O)CCc1ccc2n(cc(CCc3ccccc3)c2c1)-c1ccccc1
Show InChI InChI=1S/C25H23NO2/c27-25(28)16-13-20-12-15-24-23(17-20)21(14-11-19-7-3-1-4-8-19)18-26(24)22-9-5-2-6-10-22/h1-10,12,15,17-18H,11,13-14,16H2,(H,27,28)
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n/an/a 75n/an/an/an/an/an/a



Asubio Pharma Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cPLA2alpha isolated from human U937 cell cytoplasm assessed as suppression of [14C]arachidonic acid release from L-alpha-1-palmitoyl-2-...


J Med Chem 57: 7244-62 (2014)


Article DOI: 10.1021/jm500494y
BindingDB Entry DOI: 10.7270/Q2F47QSP
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (human))
BDBM50056736
PNG
(CHEMBL3327093)
Show SMILES Cc1ccc(cc1)-n1cc(CCc2ccccc2)c2cc(CCC(O)=O)ccc12
Show InChI InChI=1S/C26H25NO2/c1-19-7-13-23(14-8-19)27-18-22(12-9-20-5-3-2-4-6-20)24-17-21(10-15-25(24)27)11-16-26(28)29/h2-8,10,13-15,17-18H,9,11-12,16H2,1H3,(H,28,29)
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n/an/a 77n/an/an/an/an/an/a



Asubio Pharma Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cPLA2alpha isolated from human U937 cell cytoplasm assessed as suppression of [14C]arachidonic acid release from L-alpha-1-palmitoyl-2-...


J Med Chem 57: 7244-62 (2014)


Article DOI: 10.1021/jm500494y
BindingDB Entry DOI: 10.7270/Q2F47QSP
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (human))
BDBM50056729
PNG
(CHEMBL3326949)
Show SMILES Cc1c(CCc2ccccc2)c2cc(CCC(O)=O)ccc2n1-c1ccccc1
Show InChI InChI=1S/C26H25NO2/c1-19-23(15-12-20-8-4-2-5-9-20)24-18-21(14-17-26(28)29)13-16-25(24)27(19)22-10-6-3-7-11-22/h2-11,13,16,18H,12,14-15,17H2,1H3,(H,28,29)
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n/an/a 130n/an/an/an/an/an/a



Asubio Pharma Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cPLA2alpha isolated from human U937 cell cytoplasm assessed as suppression of [14C]arachidonic acid release from L-alpha-1-palmitoyl-2-...


J Med Chem 57: 7244-62 (2014)


Article DOI: 10.1021/jm500494y
BindingDB Entry DOI: 10.7270/Q2F47QSP
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (human))
BDBM50056738
PNG
(CHEMBL3327091)
Show SMILES OC(=O)CCc1ccc2n(cc(CCc3ccccc3)c2c1)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C26H22F3NO3/c27-26(28,29)33-22-12-10-21(11-13-22)30-17-20(9-6-18-4-2-1-3-5-18)23-16-19(7-14-24(23)30)8-15-25(31)32/h1-5,7,10-14,16-17H,6,8-9,15H2,(H,31,32)
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n/an/a 140n/an/an/an/an/an/a



Asubio Pharma Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cPLA2alpha isolated from human U937 cell cytoplasm assessed as suppression of [14C]arachidonic acid release from L-alpha-1-palmitoyl-2-...


J Med Chem 57: 7244-62 (2014)


Article DOI: 10.1021/jm500494y
BindingDB Entry DOI: 10.7270/Q2F47QSP
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (human))
BDBM50056731
PNG
(CHEMBL3326947)
Show SMILES OC(=O)CCc1ccc2n(cc(Cc3ccccc3)c2c1)-c1ccccc1
Show InChI InChI=1S/C24H21NO2/c26-24(27)14-12-19-11-13-23-22(16-19)20(15-18-7-3-1-4-8-18)17-25(23)21-9-5-2-6-10-21/h1-11,13,16-17H,12,14-15H2,(H,26,27)
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n/an/a 180n/an/an/an/an/an/a



Asubio Pharma Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cPLA2alpha isolated from human U937 cell cytoplasm assessed as suppression of [14C]arachidonic acid release from L-alpha-1-palmitoyl-2-...


J Med Chem 57: 7244-62 (2014)


Article DOI: 10.1021/jm500494y
BindingDB Entry DOI: 10.7270/Q2F47QSP
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (human))
BDBM50056711
PNG
(CHEMBL3326967)
Show SMILES OC(=O)CCc1ccc2n(cc(CCc3ccccc3)c2c1)-c1cccc(O)c1
Show InChI InChI=1S/C25H23NO3/c27-22-8-4-7-21(16-22)26-17-20(12-9-18-5-2-1-3-6-18)23-15-19(10-13-24(23)26)11-14-25(28)29/h1-8,10,13,15-17,27H,9,11-12,14H2,(H,28,29)
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n/an/a 190n/an/an/an/an/an/a



Asubio Pharma Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cPLA2alpha isolated from human U937 cell cytoplasm assessed as suppression of [14C]arachidonic acid release from L-alpha-1-palmitoyl-2-...


J Med Chem 57: 7244-62 (2014)


Article DOI: 10.1021/jm500494y
BindingDB Entry DOI: 10.7270/Q2F47QSP
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (human))
BDBM50056718
PNG
(CHEMBL3326960)
Show SMILES OC(=O)\C=C\c1ccc2n(cc(CCc3ccccc3)c2c1)-c1ccccc1
Show InChI InChI=1S/C25H21NO2/c27-25(28)16-13-20-12-15-24-23(17-20)21(14-11-19-7-3-1-4-8-19)18-26(24)22-9-5-2-6-10-22/h1-10,12-13,15-18H,11,14H2,(H,27,28)/b16-13+
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n/an/a 320n/an/an/an/an/an/a



Asubio Pharma Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cPLA2alpha isolated from human U937 cell cytoplasm assessed as suppression of [14C]arachidonic acid release from L-alpha-1-palmitoyl-2-...


J Med Chem 57: 7244-62 (2014)


Article DOI: 10.1021/jm500494y
BindingDB Entry DOI: 10.7270/Q2F47QSP
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (human))
BDBM50056714
PNG
(CHEMBL3326964)
Show SMILES OC(=O)CCc1ccc2c(CCc3ccccc3)cn(-c3ccccc3)c2c1
Show InChI InChI=1S/C25H23NO2/c27-25(28)16-13-20-12-15-23-21(14-11-19-7-3-1-4-8-19)18-26(24(23)17-20)22-9-5-2-6-10-22/h1-10,12,15,17-18H,11,13-14,16H2,(H,27,28)
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n/an/a 400n/an/an/an/an/an/a



Asubio Pharma Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cPLA2alpha isolated from human U937 cell cytoplasm assessed as suppression of [14C]arachidonic acid release from L-alpha-1-palmitoyl-2-...


J Med Chem 57: 7244-62 (2014)


Article DOI: 10.1021/jm500494y
BindingDB Entry DOI: 10.7270/Q2F47QSP
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (human))
BDBM50056728
PNG
(CHEMBL3326950)
Show SMILES OC(=O)CCc1ccc2n(cc(CCc3ccc(F)cc3)c2c1)-c1ccccc1
Show InChI InChI=1S/C25H22FNO2/c26-21-12-7-18(8-13-21)6-11-20-17-27(22-4-2-1-3-5-22)24-14-9-19(16-23(20)24)10-15-25(28)29/h1-5,7-9,12-14,16-17H,6,10-11,15H2,(H,28,29)
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n/an/a 570n/an/an/an/an/an/a



Asubio Pharma Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cPLA2alpha isolated from human U937 cell cytoplasm assessed as suppression of [14C]arachidonic acid release from L-alpha-1-palmitoyl-2-...


J Med Chem 57: 7244-62 (2014)


Article DOI: 10.1021/jm500494y
BindingDB Entry DOI: 10.7270/Q2F47QSP
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (human))
BDBM50056726
PNG
(CHEMBL3326952)
Show SMILES COc1ccc(CCc2cn(-c3ccccc3)c3ccc(CCC(O)=O)cc23)cc1
Show InChI InChI=1S/C26H25NO3/c1-30-23-13-8-19(9-14-23)7-12-21-18-27(22-5-3-2-4-6-22)25-15-10-20(17-24(21)25)11-16-26(28)29/h2-6,8-10,13-15,17-18H,7,11-12,16H2,1H3,(H,28,29)
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n/an/a 720n/an/an/an/an/an/a



Asubio Pharma Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cPLA2alpha isolated from human U937 cell cytoplasm assessed as suppression of [14C]arachidonic acid release from L-alpha-1-palmitoyl-2-...


J Med Chem 57: 7244-62 (2014)


Article DOI: 10.1021/jm500494y
BindingDB Entry DOI: 10.7270/Q2F47QSP
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (human))
BDBM50056710
PNG
(CHEMBL3326968)
Show SMILES OC(=O)CCc1ccc2n(cc(CCc3ccccc3)c2c1)-c1ccccc1O
Show InChI InChI=1S/C25H23NO3/c27-24-9-5-4-8-23(24)26-17-20(13-10-18-6-2-1-3-7-18)21-16-19(11-14-22(21)26)12-15-25(28)29/h1-9,11,14,16-17,27H,10,12-13,15H2,(H,28,29)
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n/an/a 780n/an/an/an/an/an/a



Asubio Pharma Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cPLA2alpha isolated from human U937 cell cytoplasm assessed as suppression of [14C]arachidonic acid release from L-alpha-1-palmitoyl-2-...


J Med Chem 57: 7244-62 (2014)


Article DOI: 10.1021/jm500494y
BindingDB Entry DOI: 10.7270/Q2F47QSP
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (human))
BDBM50056722
PNG
(CHEMBL3326956)
Show SMILES O=C(CCc1ccc2n(cc(CCc3ccccc3)c2c1)-c1ccccc1)NC#N
Show InChI InChI=1S/C26H23N3O/c27-19-28-26(30)16-13-21-12-15-25-24(17-21)22(14-11-20-7-3-1-4-8-20)18-29(25)23-9-5-2-6-10-23/h1-10,12,15,17-18H,11,13-14,16H2,(H,28,30)
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n/an/a 980n/an/an/an/an/an/a



Asubio Pharma Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cPLA2alpha isolated from human U937 cell cytoplasm assessed as suppression of [14C]arachidonic acid release from L-alpha-1-palmitoyl-2-...


J Med Chem 57: 7244-62 (2014)


Article DOI: 10.1021/jm500494y
BindingDB Entry DOI: 10.7270/Q2F47QSP
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (human))
BDBM50056725
PNG
(CHEMBL3326953)
Show SMILES COc1cccc(CCc2cn(-c3ccccc3)c3ccc(CCC(O)=O)cc23)c1
Show InChI InChI=1S/C26H25NO3/c1-30-23-9-5-6-19(16-23)10-13-21-18-27(22-7-3-2-4-8-22)25-14-11-20(17-24(21)25)12-15-26(28)29/h2-9,11,14,16-18H,10,12-13,15H2,1H3,(H,28,29)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Asubio Pharma Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cPLA2alpha isolated from human U937 cell cytoplasm assessed as suppression of [14C]arachidonic acid release from L-alpha-1-palmitoyl-2-...


J Med Chem 57: 7244-62 (2014)


Article DOI: 10.1021/jm500494y
BindingDB Entry DOI: 10.7270/Q2F47QSP
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (human))
BDBM50056734
PNG
(CHEMBL3327096)
Show SMILES OC(=O)\C=C\c1ccc(Sc2ccc(Cl)cc2)c(c1)[N+]([O-])=O
Show InChI InChI=1S/C15H10ClNO4S/c16-11-3-5-12(6-4-11)22-14-7-1-10(2-8-15(18)19)9-13(14)17(20)21/h1-9H,(H,18,19)/b8-2+
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n/an/a 1.00E+3n/an/an/an/an/an/a



Asubio Pharma Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cPLA2alpha isolated from human U937 cell cytoplasm assessed as suppression of [14C]arachidonic acid release from L-alpha-1-palmitoyl-2-...


J Med Chem 57: 7244-62 (2014)


Article DOI: 10.1021/jm500494y
BindingDB Entry DOI: 10.7270/Q2F47QSP
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (human))
BDBM50056727
PNG
(CHEMBL3326951)
Show SMILES OC(=O)CCc1ccc2n(cc(CCc3ccc(Cl)cc3)c2c1)-c1ccccc1
Show InChI InChI=1S/C25H22ClNO2/c26-21-12-7-18(8-13-21)6-11-20-17-27(22-4-2-1-3-5-22)24-14-9-19(16-23(20)24)10-15-25(28)29/h1-5,7-9,12-14,16-17H,6,10-11,15H2,(H,28,29)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Asubio Pharma Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cPLA2alpha isolated from human U937 cell cytoplasm assessed as suppression of [14C]arachidonic acid release from L-alpha-1-palmitoyl-2-...


J Med Chem 57: 7244-62 (2014)


Article DOI: 10.1021/jm500494y
BindingDB Entry DOI: 10.7270/Q2F47QSP
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (human))
BDBM50056719
PNG
(CHEMBL3326959)
Show SMILES FC(F)(F)C(=O)CCc1ccc2n(cc(CCc3ccccc3)c2c1)-c1ccccc1
Show InChI InChI=1S/C26H22F3NO/c27-26(28,29)25(31)16-13-20-12-15-24-23(17-20)21(14-11-19-7-3-1-4-8-19)18-30(24)22-9-5-2-6-10-22/h1-10,12,15,17-18H,11,13-14,16H2
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n/an/a 1.20E+3n/an/an/an/an/an/a



Asubio Pharma Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cPLA2alpha isolated from human U937 cell cytoplasm assessed as suppression of [14C]arachidonic acid release from L-alpha-1-palmitoyl-2-...


J Med Chem 57: 7244-62 (2014)


Article DOI: 10.1021/jm500494y
BindingDB Entry DOI: 10.7270/Q2F47QSP
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (human))
BDBM50056724
PNG
(CHEMBL3326954)
Show SMILES COc1ccc(CCc2cn(-c3ccccc3)c3ccc(CCC(O)=O)cc23)cc1OC
Show InChI InChI=1S/C27H27NO4/c1-31-25-14-10-20(17-26(25)32-2)8-12-21-18-28(22-6-4-3-5-7-22)24-13-9-19(16-23(21)24)11-15-27(29)30/h3-7,9-10,13-14,16-18H,8,11-12,15H2,1-2H3,(H,29,30)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Asubio Pharma Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cPLA2alpha isolated from human U937 cell cytoplasm assessed as suppression of [14C]arachidonic acid release from L-alpha-1-palmitoyl-2-...


J Med Chem 57: 7244-62 (2014)


Article DOI: 10.1021/jm500494y
BindingDB Entry DOI: 10.7270/Q2F47QSP
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (human))
BDBM50056713
PNG
(CHEMBL3326965)
Show SMILES OC(=O)CCc1ccc2n(Cc3ccccc3)cc(CCc3ccccc3)c2c1
Show InChI InChI=1S/C26H25NO2/c28-26(29)16-13-21-12-15-25-24(17-21)23(14-11-20-7-3-1-4-8-20)19-27(25)18-22-9-5-2-6-10-22/h1-10,12,15,17,19H,11,13-14,16,18H2,(H,28,29)
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n/an/a 1.60E+3n/an/an/an/an/an/a



Asubio Pharma Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cPLA2alpha isolated from human U937 cell cytoplasm assessed as suppression of [14C]arachidonic acid release from L-alpha-1-palmitoyl-2-...


J Med Chem 57: 7244-62 (2014)


Article DOI: 10.1021/jm500494y
BindingDB Entry DOI: 10.7270/Q2F47QSP
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (human))
BDBM50056715
PNG
(CHEMBL3326963)
Show SMILES OC(=O)CCOc1ccc2n(cc(CCc3ccccc3)c2c1)-c1ccccc1
Show InChI InChI=1S/C25H23NO3/c27-25(28)15-16-29-22-13-14-24-23(17-22)20(12-11-19-7-3-1-4-8-19)18-26(24)21-9-5-2-6-10-21/h1-10,13-14,17-18H,11-12,15-16H2,(H,27,28)
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n/an/a 1.70E+3n/an/an/an/an/an/a



Asubio Pharma Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cPLA2alpha isolated from human U937 cell cytoplasm assessed as suppression of [14C]arachidonic acid release from L-alpha-1-palmitoyl-2-...


J Med Chem 57: 7244-62 (2014)


Article DOI: 10.1021/jm500494y
BindingDB Entry DOI: 10.7270/Q2F47QSP
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (human))
BDBM50056717
PNG
(CHEMBL3326961)
Show SMILES OC(=O)COc1ccc2n(cc(CCc3ccccc3)c2c1)-c1ccccc1
Show InChI InChI=1S/C24H21NO3/c26-24(27)17-28-21-13-14-23-22(15-21)19(12-11-18-7-3-1-4-8-18)16-25(23)20-9-5-2-6-10-20/h1-10,13-16H,11-12,17H2,(H,26,27)
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n/an/a 3.90E+3n/an/an/an/an/an/a



Asubio Pharma Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cPLA2alpha isolated from human U937 cell cytoplasm assessed as suppression of [14C]arachidonic acid release from L-alpha-1-palmitoyl-2-...


J Med Chem 57: 7244-62 (2014)


Article DOI: 10.1021/jm500494y
BindingDB Entry DOI: 10.7270/Q2F47QSP
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (human))
BDBM50056735
PNG
(CHEMBL3327097)
Show SMILES OC(=O)\C=C\c1ccc2n(ccc2c1)-c1ccccc1
Show InChI InChI=1S/C17H13NO2/c19-17(20)9-7-13-6-8-16-14(12-13)10-11-18(16)15-4-2-1-3-5-15/h1-12H,(H,19,20)/b9-7+
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n/an/a 1.00E+4n/an/an/an/an/an/a



Asubio Pharma Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cPLA2alpha isolated from human U937 cell cytoplasm assessed as suppression of [14C]arachidonic acid release from L-alpha-1-palmitoyl-2-...


J Med Chem 57: 7244-62 (2014)


Article DOI: 10.1021/jm500494y
BindingDB Entry DOI: 10.7270/Q2F47QSP
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (human))
BDBM50056721
PNG
(CHEMBL3326957)
Show SMILES C(Cc1ccc2n(cc(CCc3ccccc3)c2c1)-c1ccccc1)c1nnn[nH]1
Show InChI InChI=1S/C25H23N5/c1-3-7-19(8-4-1)11-14-21-18-30(22-9-5-2-6-10-22)24-15-12-20(17-23(21)24)13-16-25-26-28-29-27-25/h1-10,12,15,17-18H,11,13-14,16H2,(H,26,27,28,29)
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n/an/a 1.30E+4n/an/an/an/an/an/a



Asubio Pharma Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cPLA2alpha isolated from human U937 cell cytoplasm assessed as suppression of [14C]arachidonic acid release from L-alpha-1-palmitoyl-2-...


J Med Chem 57: 7244-62 (2014)


Article DOI: 10.1021/jm500494y
BindingDB Entry DOI: 10.7270/Q2F47QSP
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (human))
BDBM50056716
PNG
(CHEMBL3326962)
Show SMILES CC(Oc1ccc2n(cc(CCc3ccccc3)c2c1)-c1ccccc1)C(O)=O
Show InChI InChI=1S/C25H23NO3.C4H11NO3/c1-18(25(27)28)29-22-14-15-24-23(16-22)20(13-12-19-8-4-2-5-9-19)17-26(24)21-10-6-3-7-11-21;5-4(1-6,2-7)3-8/h2-11,14-18H,12-13H2,1H3,(H,27,28);6-8H,1-3,5H2
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n/an/a 1.50E+4n/an/an/an/an/an/a



Asubio Pharma Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cPLA2alpha isolated from human U937 cell cytoplasm assessed as suppression of [14C]arachidonic acid release from L-alpha-1-palmitoyl-2-...


J Med Chem 57: 7244-62 (2014)


Article DOI: 10.1021/jm500494y
BindingDB Entry DOI: 10.7270/Q2F47QSP
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (human))
BDBM50056723
PNG
(CHEMBL3326955)
Show SMILES ONC(=O)CCc1ccc2n(cc(CCc3ccccc3)c2c1)-c1ccccc1
Show InChI InChI=1S/C25H24N2O2/c28-25(26-29)16-13-20-12-15-24-23(17-20)21(14-11-19-7-3-1-4-8-19)18-27(24)22-9-5-2-6-10-22/h1-10,12,15,17-18,29H,11,13-14,16H2,(H,26,28)
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n/an/a 1.60E+4n/an/an/an/an/an/a



Asubio Pharma Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cPLA2alpha isolated from human U937 cell cytoplasm assessed as suppression of [14C]arachidonic acid release from L-alpha-1-palmitoyl-2-...


J Med Chem 57: 7244-62 (2014)


Article DOI: 10.1021/jm500494y
BindingDB Entry DOI: 10.7270/Q2F47QSP
More data for this
Ligand-Target Pair
cPLA2 C2


(Homo sapiens (human))
BDBM50056720
PNG
(CHEMBL3326958)
Show SMILES NC(=O)CCc1ccc2n(cc(CCc3ccccc3)c2c1)-c1ccccc1
Show InChI InChI=1S/C25H24N2O/c26-25(28)16-13-20-12-15-24-23(17-20)21(14-11-19-7-3-1-4-8-19)18-27(24)22-9-5-2-6-10-22/h1-10,12,15,17-18H,11,13-14,16H2,(H2,26,28)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Asubio Pharma Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of cPLA2alpha isolated from human U937 cell cytoplasm assessed as suppression of [14C]arachidonic acid release from L-alpha-1-palmitoyl-2-...


J Med Chem 57: 7244-62 (2014)


Article DOI: 10.1021/jm500494y
BindingDB Entry DOI: 10.7270/Q2F47QSP
More data for this
Ligand-Target Pair