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Found 448 hits from Axovant Sciences GmbH   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))
BDBM322432
PNG
((R)-7-phenyl-N-(1'-azaspiro[cyclopropane-1,2'-bicy...)
Show SMILES O=C(N[C@@H]1C2CCN(CC2)C11CC1)c1cc2cccc(-c3ccccc3)c2s1
Show InChI InChI=1S/C24H24N2OS/c27-23(25-22-17-9-13-26(14-10-17)24(22)11-12-24)20-15-18-7-4-8-19(21(18)28-20)16-5-2-1-3-6-16/h1-8,15,17,22H,9-14H2,(H,25,27)/t22-/m1/s1
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30n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
[3H]BRL 43694 competition binding assay was performed under contract by Cerep Poitiers, France following the methods described in Hope, A. G et al., ...


US Patent US10183938 (2019)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (human))
BDBM322406
PNG
((R)-7-cyclopropyl-N-(1'-azaspiro[cyclopropane-1,2'...)
Show SMILES O=C(N[C@@H]1C2CCN(CC2)C11CC1)c1cc2cccc(C3CC3)c2s1
Show InChI InChI=1S/C21H24N2OS/c24-20(22-19-14-6-10-23(11-7-14)21(19)8-9-21)17-12-15-2-1-3-16(13-4-5-13)18(15)25-17/h1-3,12-14,19H,4-11H2,(H,22,24)/t19-/m1/s1
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36n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp...


US Patent US10183938 (2019)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (human))
BDBM322274
PNG
(7-chloro-N-(1'-azaspiro[cyclopropane-1,2'-bicyclo[...)
Show SMILES Clc1cccc2cc(sc12)C(=O)NC1C2CCN(CC2)C11CC1
Show InChI InChI=1S/C18H19ClN2OS/c19-13-3-1-2-12-10-14(23-15(12)13)17(22)20-16-11-4-8-21(9-5-11)18(16)6-7-18/h1-3,10-11,16H,4-9H2,(H,20,22)
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37n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp...


US Patent US10183938 (2019)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (human))
BDBM322452
PNG
((R)-6-chloro-7-methyl-N-(1'-azaspiro[cyclopropane-...)
Show SMILES Cc1c(Cl)ccc2cc(sc12)C(=O)N[C@@H]1C2CCN(CC2)C11CC1
Show InChI InChI=1S/C19H21ClN2OS/c1-11-14(20)3-2-13-10-15(24-16(11)13)18(23)21-17-12-4-8-22(9-5-12)19(17)6-7-19/h2-3,10,12,17H,4-9H2,1H3,(H,21,23)/t17-/m1/s1
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47n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp...


US Patent US10183938 (2019)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))
BDBM322274
PNG
(7-chloro-N-(1'-azaspiro[cyclopropane-1,2'-bicyclo[...)
Show SMILES Clc1cccc2cc(sc12)C(=O)NC1C2CCN(CC2)C11CC1
Show InChI InChI=1S/C18H19ClN2OS/c19-13-3-1-2-12-10-14(23-15(12)13)17(22)20-16-11-4-8-21(9-5-11)18(16)6-7-18/h1-3,10-11,16H,4-9H2,(H,20,22)
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48n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
[3H]BRL 43694 competition binding assay was performed under contract by Cerep Poitiers, France following the methods described in Hope, A. G et al., ...


US Patent US10183938 (2019)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (human))
BDBM322387
PNG
((R)-6,7-dichloro-N-(1'-azaspiro[cyclopropane-1,2'-...)
Show SMILES Clc1ccc2cc(sc2c1Cl)C(=O)N[C@@H]1C2CCN(CC2)C11CC1
Show InChI InChI=1S/C18H18Cl2N2OS/c19-12-2-1-11-9-13(24-15(11)14(12)20)17(23)21-16-10-3-7-22(8-4-10)18(16)5-6-18/h1-2,9-10,16H,3-8H2,(H,21,23)/t16-/m1/s1
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54.5n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp...


US Patent US10183938 (2019)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (human))
BDBM322402
PNG
((R)-7-methoxy-N-(1'-azaspiro[cyclopropane-1,2'-bic...)
Show SMILES COc1cccc2cc(sc12)C(=O)N[C@@H]1C2CCN(CC2)C11CC1
Show InChI InChI=1S/C19H22N2O2S/c1-23-14-4-2-3-13-11-15(24-16(13)14)18(22)20-17-12-5-9-21(10-6-12)19(17)7-8-19/h2-4,11-12,17H,5-10H2,1H3,(H,20,22)/t17-/m1/s1
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58n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp...


US Patent US10183938 (2019)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (human))
BDBM322271
PNG
(N-(1''-azaspiro[cyclopropane-1,2''-bicyclo[2.2.2]o...)
Show SMILES O=C(NC1C2CCN(CC2)C11CC1)c1cc2ccccc2s1
Show InChI InChI=1S/C18H20N2OS/c21-17(15-11-13-3-1-2-4-14(13)22-15)19-16-12-5-9-20(10-6-12)18(16)7-8-18/h1-4,11-12,16H,5-10H2,(H,19,21)
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61n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp...


US Patent US10183938 (2019)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (human))
BDBM322275
PNG
(7-fluoro-N-(1''-azaspiro[cyclopropane-1,2''-bicycl...)
Show SMILES Fc1cccc2cc(sc12)C(=O)NC1C2CCN(CC2)C11CC1
Show InChI InChI=1S/C18H19FN2OS/c19-13-3-1-2-12-10-14(23-15(12)13)17(22)20-16-11-4-8-21(9-5-11)18(16)6-7-18/h1-3,10-11,16H,4-9H2,(H,20,22)
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75n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp...


US Patent US10183938 (2019)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))
BDBM322440
PNG
((R)-N-(1'-azaspiro[cyclopropane-1,2'-bicyclo[2.2.2...)
Show SMILES O=C(N[C@@H]1C2CCN(CC2)C11CC1)c1n[nH]c2ccccc12
Show InChI InChI=1S/C17H20N4O/c22-16(14-12-3-1-2-4-13(12)19-20-14)18-15-11-5-9-21(10-6-11)17(15)7-8-17/h1-4,11,15H,5-10H2,(H,18,22)(H,19,20)/t15-/m1/s1
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79n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
[3H]BRL 43694 competition binding assay was performed under contract by Cerep Poitiers, France following the methods described in Hope, A. G et al., ...


US Patent US10183938 (2019)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))
BDBM322427
PNG
((R)-N-(1'-azaspiro[cyclopropane-1,2'-bicyclo[2.2.2...)
Show SMILES O=C(N[C@@H]1C2CCN(CC2)C11CC1)c1cc2cccc(-c3nccs3)c2s1
Show InChI InChI=1S/C21H21N3OS2/c25-19(23-18-13-4-9-24(10-5-13)21(18)6-7-21)16-12-14-2-1-3-15(17(14)27-16)20-22-8-11-26-20/h1-3,8,11-13,18H,4-7,9-10H2,(H,23,25)/t18-/m1/s1
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83n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
[3H]BRL 43694 competition binding assay was performed under contract by Cerep Poitiers, France following the methods described in Hope, A. G et al., ...


US Patent US10183938 (2019)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (human))
BDBM322385
PNG
((R)-6-chloro-N-(2,2-dimethylquinuclidin-3-yl)-7-me...)
Show SMILES Cc1c(Cl)ccc2cc(sc12)C(=O)N[C@@H]1C2CCN(CC2)C1(C)C
Show InChI InChI=1S/C19H23ClN2OS/c1-11-14(20)5-4-13-10-15(24-16(11)13)18(23)21-17-12-6-8-22(9-7-12)19(17,2)3/h4-5,10,12,17H,6-9H2,1-3H3,(H,21,23)/t17-/m1/s1
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92n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp...


US Patent US10183938 (2019)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (human))
BDBM322280
PNG
(N-(1''-azaspiro[cyclopropane-1,2''-bicyclo[2.2.2]o...)
Show SMILES FC(F)(F)c1cccc2cc(sc12)C(=O)NC1C2CCN(CC2)C11CC1
Show InChI InChI=1S/C19H19F3N2OS/c20-19(21,22)13-3-1-2-12-10-14(26-15(12)13)17(25)23-16-11-4-8-24(9-5-11)18(16)6-7-18/h1-3,10-11,16H,4-9H2,(H,23,25)
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98n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp...


US Patent US10183938 (2019)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (human))
BDBM322451
PNG
((R)-N-(1'-azaspiro[cyclopropane-1,2'-bicyclo[2.2.2...)
Show SMILES O=C(N[C@@H]1C2CCN(CC2)C11CC1)c1cc2ccc3OCCCc3c2s1
Show InChI InChI=1S/C21H24N2O2S/c24-20(22-19-13-5-9-23(10-6-13)21(19)7-8-21)17-12-14-3-4-16-15(18(14)26-17)2-1-11-25-16/h3-4,12-13,19H,1-2,5-11H2,(H,22,24)/t19-/m1/s1
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100n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp...


US Patent US10183938 (2019)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))
BDBM322368
PNG
((R)-N-(2,2-dimethylquinuclidin-3-yl)-7-phenylbenzo...)
Show SMILES CC1(C)[C@H](NC(=O)c2cc3cccc(-c4ccccc4)c3s2)C2CCN1CC2
Show InChI InChI=1S/C24H26N2OS/c1-24(2)22(17-11-13-26(24)14-12-17)25-23(27)20-15-18-9-6-10-19(21(18)28-20)16-7-4-3-5-8-16/h3-10,15,17,22H,11-14H2,1-2H3,(H,25,27)/t22-/m1/s1
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100n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
[3H]BRL 43694 competition binding assay was performed under contract by Cerep Poitiers, France following the methods described in Hope, A. G et al., ...


US Patent US10183938 (2019)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (human))
BDBM322283
PNG
(6-amino-N-(1''-azaspiro[cyclopropane-1,2''-bicyclo...)
Show SMILES Nc1ccc2cc(sc2c1)C(=O)NC1C2CCN(CC2)C11CC1
Show InChI InChI=1S/C18H21N3OS/c19-13-2-1-12-9-15(23-14(12)10-13)17(22)20-16-11-3-7-21(8-4-11)18(16)5-6-18/h1-2,9-11,16H,3-8,19H2,(H,20,22)
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100n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp...


US Patent US10183938 (2019)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))
BDBM322430
PNG
((R)-7-(tert-butyl)-N-(1'-azaspiro[cyclopropane-1,2...)
Show SMILES CC(C)(C)c1cccc2cc(sc12)C(=O)N[C@@H]1C2CCN(CC2)C11CC1
Show InChI InChI=1S/C22H28N2OS/c1-21(2,3)16-6-4-5-15-13-17(26-18(15)16)20(25)23-19-14-7-11-24(12-8-14)22(19)9-10-22/h4-6,13-14,19H,7-12H2,1-3H3,(H,23,25)/t19-/m1/s1
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110n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
[3H]BRL 43694 competition binding assay was performed under contract by Cerep Poitiers, France following the methods described in Hope, A. G et al., ...


US Patent US10183938 (2019)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (human))
BDBM322401
PNG
((R)-7-cyano-N-(1'-azaspiro[cyclopropane-1,2'-bicyc...)
Show SMILES O=C(N[C@@H]1C2CCN(CC2)C11CC1)c1cc2cccc(C#N)c2s1
Show InChI InChI=1S/C19H19N3OS/c20-11-14-3-1-2-13-10-15(24-16(13)14)18(23)21-17-12-4-8-22(9-5-12)19(17)6-7-19/h1-3,10,12,17H,4-9H2,(H,21,23)/t17-/m1/s1
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110n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp...


US Patent US10183938 (2019)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (human))
BDBM322193
PNG
((R)-7-chloro-N-(2,2-dimethylquinuclidin-3-yl)benzo...)
Show SMILES CC1(C)[C@H](NC(=O)c2cc3cccc(Cl)c3s2)C2CCN1CC2
Show InChI InChI=1S/C18H21ClN2OS/c1-18(2)16(11-6-8-21(18)9-7-11)20-17(22)14-10-12-4-3-5-13(19)15(12)23-14/h3-5,10-11,16H,6-9H2,1-2H3,(H,20,22)/t16-/m1/s1
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110n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp...


US Patent US10183938 (2019)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (human))
BDBM322277
PNG
(N-(1'-azaspiro[cyclopropane-1,2'-bicyclo[2.2.2]oct...)
Show SMILES O=C(NC1C2CCN(CC2)C11CC1)c1ccc2ccsc2c1
Show InChI InChI=1S/C18H20N2OS/c21-17(14-2-1-12-5-10-22-15(12)11-14)19-16-13-3-8-20(9-4-13)18(16)6-7-18/h1-2,5,10-11,13,16H,3-4,6-9H2,(H,19,21)
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110n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp...


US Patent US10183938 (2019)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (human))
BDBM322345
PNG
((R)-6,7-dichloro-N-(2,2-dimethylquinuclidin-3-yl)b...)
Show SMILES CC1(C)[C@H](NC(=O)c2cc3ccc(Cl)c(Cl)c3s2)C2CCN1CC2
Show InChI InChI=1S/C18H20Cl2N2OS/c1-18(2)16(10-5-7-22(18)8-6-10)21-17(23)13-9-11-3-4-12(19)14(20)15(11)24-13/h3-4,9-10,16H,5-8H2,1-2H3,(H,21,23)/t16-/m1/s1
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110n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp...


US Patent US10183938 (2019)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))
BDBM322275
PNG
(7-fluoro-N-(1''-azaspiro[cyclopropane-1,2''-bicycl...)
Show SMILES Fc1cccc2cc(sc12)C(=O)NC1C2CCN(CC2)C11CC1
Show InChI InChI=1S/C18H19FN2OS/c19-13-3-1-2-12-10-14(23-15(12)13)17(22)20-16-11-4-8-21(9-5-11)18(16)6-7-18/h1-3,10-11,16H,4-9H2,(H,20,22)
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110n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
[3H]BRL 43694 competition binding assay was performed under contract by Cerep Poitiers, France following the methods described in Hope, A. G et al., ...


US Patent US10183938 (2019)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (human))
BDBM322302
PNG
(6-methoxy-N-(1''-azaspiro[cyclopropane-1,2''-bicyc...)
Show SMILES COc1ccc2cc(sc2c1)C(=O)NC1C2CCN(CC2)C11CC1
Show InChI InChI=1S/C19H22N2O2S/c1-23-14-3-2-13-10-16(24-15(13)11-14)18(22)20-17-12-4-8-21(9-5-12)19(17)6-7-19/h2-3,10-12,17H,4-9H2,1H3,(H,20,22)
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120n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp...


US Patent US10183938 (2019)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (human))
BDBM322422
PNG
((R)-7-methyl-N-(1'-azaspiro[cyclopropane-1,2'-bicy...)
Show SMILES Cc1cccc2cc(sc12)C(=O)N[C@@H]1C2CCN(CC2)C11CC1
Show InChI InChI=1S/C19H22N2OS/c1-12-3-2-4-14-11-15(23-16(12)14)18(22)20-17-13-5-9-21(10-6-13)19(17)7-8-19/h2-4,11,13,17H,5-10H2,1H3,(H,20,22)/t17-/m1/s1
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130n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp...


US Patent US10183938 (2019)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))
BDBM322422
PNG
((R)-7-methyl-N-(1'-azaspiro[cyclopropane-1,2'-bicy...)
Show SMILES Cc1cccc2cc(sc12)C(=O)N[C@@H]1C2CCN(CC2)C11CC1
Show InChI InChI=1S/C19H22N2OS/c1-12-3-2-4-14-11-15(23-16(12)14)18(22)20-17-13-5-9-21(10-6-13)19(17)7-8-19/h2-4,11,13,17H,5-10H2,1H3,(H,20,22)/t17-/m1/s1
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130n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
[3H]BRL 43694 competition binding assay was performed under contract by Cerep Poitiers, France following the methods described in Hope, A. G et al., ...


US Patent US10183938 (2019)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (human))
BDBM322354
PNG
((R)-7-cyclopropyl-N-(2,2-dimethylquinuclidin-3-yl)...)
Show SMILES CC1(C)[C@H](NC(=O)c2cc3cccc(C4CC4)c3s2)C2CCN1CC2
Show InChI InChI=1S/C21H26N2OS/c1-21(2)19(14-8-10-23(21)11-9-14)22-20(24)17-12-15-4-3-5-16(13-6-7-13)18(15)25-17/h3-5,12-14,19H,6-11H2,1-2H3,(H,22,24)/t19-/m1/s1
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140n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp...


US Patent US10183938 (2019)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (human))
BDBM322362
PNG
((R)-N-(2,2-dimethylquinuclidin-3-yl)-7-methylbenzo...)
Show SMILES Cc1cccc2cc(sc12)C(=O)N[C@@H]1C2CCN(CC2)C1(C)C
Show InChI InChI=1S/C19H24N2OS/c1-12-5-4-6-14-11-15(23-16(12)14)18(22)20-17-13-7-9-21(10-8-13)19(17,2)3/h4-6,11,13,17H,7-10H2,1-3H3,(H,20,22)/t17-/m1/s1
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140n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp...


US Patent US10183938 (2019)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (human))
BDBM322427
PNG
((R)-N-(1'-azaspiro[cyclopropane-1,2'-bicyclo[2.2.2...)
Show SMILES O=C(N[C@@H]1C2CCN(CC2)C11CC1)c1cc2cccc(-c3nccs3)c2s1
Show InChI InChI=1S/C21H21N3OS2/c25-19(23-18-13-4-9-24(10-5-13)21(18)6-7-21)16-12-14-2-1-3-15(17(14)27-16)20-22-8-11-26-20/h1-3,8,11-13,18H,4-7,9-10H2,(H,23,25)/t18-/m1/s1
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147n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp...


US Patent US10183938 (2019)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (human))
BDBM322448
PNG
((R)-N-(1'-azaspiro[cyclopropane-1,2'-bicyclo[2.2.2...)
Show SMILES O=C(N[C@@H]1C2CCN(CC2)C11CC1)c1cc2ccc3CCCOc3c2s1
Show InChI InChI=1S/C21H24N2O2S/c24-20(22-19-14-5-9-23(10-6-14)21(19)7-8-21)16-12-15-4-3-13-2-1-11-25-17(13)18(15)26-16/h3-4,12,14,19H,1-2,5-11H2,(H,22,24)/t19-/m1/s1
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150n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp...


US Patent US10183938 (2019)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (human))
BDBM322342
PNG
((R)-7-fluoro-6-methyl-N-(1'-azaspiro[cyclopropane-...)
Show SMILES Cc1ccc2cc(sc2c1F)C(=O)N[C@@H]1C2CCN(CC2)C11CC1
Show InChI InChI=1S/C19H21FN2OS/c1-11-2-3-13-10-14(24-16(13)15(11)20)18(23)21-17-12-4-8-22(9-5-12)19(17)6-7-19/h2-3,10,12,17H,4-9H2,1H3,(H,21,23)/t17-/m1/s1
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150n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp...


US Patent US10183938 (2019)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (human))
BDBM322380
PNG
((R)-N-(2,2-dimethylquinuclidin-3-yl)-7-(methoxymet...)
Show SMILES COCc1cccc2cc(sc12)C(=O)N[C@@H]1C2CCN(CC2)C1(C)C
Show InChI InChI=1S/C20H26N2O2S/c1-20(2)18(13-7-9-22(20)10-8-13)21-19(23)16-11-14-5-4-6-15(12-24-3)17(14)25-16/h4-6,11,13,18H,7-10,12H2,1-3H3,(H,21,23)/t18-/m1/s1
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155n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp...


US Patent US10183938 (2019)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (human))
BDBM322444
PNG
((R)-6-fluoro-7-methoxy-N-(1'-azaspiro[cyclopropane...)
Show SMILES COc1c(F)ccc2cc(sc12)C(=O)N[C@@H]1C2CCN(CC2)C11CC1
Show InChI InChI=1S/C19H21FN2O2S/c1-24-15-13(20)3-2-12-10-14(25-16(12)15)18(23)21-17-11-4-8-22(9-5-11)19(17)6-7-19/h2-3,10-11,17H,4-9H2,1H3,(H,21,23)/t17-/m1/s1
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160n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp...


US Patent US10183938 (2019)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))
BDBM322437
PNG
((R)-7-isopropoxy-N-(1'-azaspiro[cyclopropane-1,2'-...)
Show SMILES CC(C)Oc1cccc2cc(sc12)C(=O)N[C@@H]1C2CCN(CC2)C11CC1
Show InChI InChI=1S/C21H26N2O2S/c1-13(2)25-16-5-3-4-15-12-17(26-18(15)16)20(24)22-19-14-6-10-23(11-7-14)21(19)8-9-21/h3-5,12-14,19H,6-11H2,1-2H3,(H,22,24)/t19-/m1/s1
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160n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
[3H]BRL 43694 competition binding assay was performed under contract by Cerep Poitiers, France following the methods described in Hope, A. G et al., ...


US Patent US10183938 (2019)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (human))
BDBM322393
PNG
((R)-7-chloro-6-methyl-N-(1'-azaspiro[cyclopropane-...)
Show SMILES Cc1ccc2cc(sc2c1Cl)C(=O)N[C@@H]1C2CCN(CC2)C11CC1
Show InChI InChI=1S/C19H21ClN2OS/c1-11-2-3-13-10-14(24-16(13)15(11)20)18(23)21-17-12-4-8-22(9-5-12)19(17)6-7-19/h2-3,10,12,17H,4-9H2,1H3,(H,21,23)/t17-/m1/s1
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160n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp...


US Patent US10183938 (2019)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (human))
BDBM322449
PNG
((R)-2-methyl-N-(1'-azaspiro[cyclopropane-1,2'-bicy...)
Show SMILES Cc1cc2ccc(cc2s1)C(=O)N[C@@H]1C2CCN(CC2)C11CC1
Show InChI InChI=1S/C19H22N2OS/c1-12-10-14-2-3-15(11-16(14)23-12)18(22)20-17-13-4-8-21(9-5-13)19(17)6-7-19/h2-3,10-11,13,17H,4-9H2,1H3,(H,20,22)/t17-/m1/s1
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160n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp...


US Patent US10183938 (2019)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))
BDBM322362
PNG
((R)-N-(2,2-dimethylquinuclidin-3-yl)-7-methylbenzo...)
Show SMILES Cc1cccc2cc(sc12)C(=O)N[C@@H]1C2CCN(CC2)C1(C)C
Show InChI InChI=1S/C19H24N2OS/c1-12-5-4-6-14-11-15(23-16(12)14)18(22)20-17-13-7-9-21(10-8-13)19(17,2)3/h4-6,11,13,17H,7-10H2,1-3H3,(H,20,22)/t17-/m1/s1
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170n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
[3H]BRL 43694 competition binding assay was performed under contract by Cerep Poitiers, France following the methods described in Hope, A. G et al., ...


US Patent US10183938 (2019)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (human))
BDBM322382
PNG
((R)-N-(2,2-dimethylquinuclidin-3-yl)-8,9-dihydro-7...)
Show SMILES CC1(C)[C@H](NC(=O)c2cc3ccc4OCCCc4c3s2)C2CCN1CC2
Show InChI InChI=1S/C21H26N2O2S/c1-21(2)19(13-7-9-23(21)10-8-13)22-20(24)17-12-14-5-6-16-15(18(14)26-17)4-3-11-25-16/h5-6,12-13,19H,3-4,7-11H2,1-2H3,(H,22,24)/t19-/m1/s1
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180n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp...


US Patent US10183938 (2019)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (human))
BDBM322286
PNG
(6-chloro-N-(1''-azaspiro[cyclopropane-1,2''-bicycl...)
Show SMILES Clc1ccc2cc(sc2c1)C(=O)NC1C2CCN(CC2)C11CC1
Show InChI InChI=1S/C18H19ClN2OS/c19-13-2-1-12-9-15(23-14(12)10-13)17(22)20-16-11-3-7-21(8-4-11)18(16)5-6-18/h1-2,9-11,16H,3-8H2,(H,20,22)
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180n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp...


US Patent US10183938 (2019)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (human))
BDBM322292
PNG
(6-methyl-N-(1''-azaspiro[cyclopropane-1,2''-bicycl...)
Show SMILES Cc1ccc2cc(sc2c1)C(=O)NC1C2CCN(CC2)C11CC1
Show InChI InChI=1S/C19H22N2OS/c1-12-2-3-14-11-16(23-15(14)10-12)18(22)20-17-13-4-8-21(9-5-13)19(17)6-7-19/h2-3,10-11,13,17H,4-9H2,1H3,(H,20,22)
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180n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp...


US Patent US10183938 (2019)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (human))
BDBM322269
PNG
((R)-7-chloro-N-(2,2-dimethylquinuclidin-3-yl)-6-me...)
Show SMILES Cc1ccc2cc(sc2c1Cl)C(=O)N[C@@H]1C2CCN(CC2)C1(C)C
Show InChI InChI=1S/C19H23ClN2OS/c1-11-4-5-13-10-14(24-16(13)15(11)20)18(23)21-17-12-6-8-22(9-7-12)19(17,2)3/h4-5,10,12,17H,6-9H2,1-3H3,(H,21,23)/t17-/m1/s1
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180n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp...


US Patent US10183938 (2019)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (human))
BDBM322445
PNG
((R)-7-cyano-6-methyl-N-(1'-azaspiro[cyclopropane-1...)
Show SMILES Cc1ccc2cc(sc2c1C#N)C(=O)N[C@@H]1C2CCN(CC2)C11CC1
Show InChI InChI=1S/C20H21N3OS/c1-12-2-3-14-10-16(25-17(14)15(12)11-21)19(24)22-18-13-4-8-23(9-5-13)20(18)6-7-20/h2-3,10,13,18H,4-9H2,1H3,(H,22,24)/t18-/m1/s1
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190n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp...


US Patent US10183938 (2019)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (human))
BDBM322399
PNG
((R)-7-chloro-6-fluoro-N-(1'-azaspiro[cyclopropane-...)
Show SMILES Fc1ccc2cc(sc2c1Cl)C(=O)N[C@@H]1C2CCN(CC2)C11CC1
Show InChI InChI=1S/C18H18ClFN2OS/c19-14-12(20)2-1-11-9-13(24-15(11)14)17(23)21-16-10-3-7-22(8-4-10)18(16)5-6-18/h1-2,9-10,16H,3-8H2,(H,21,23)/t16-/m1/s1
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200n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp...


US Patent US10183938 (2019)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (human))
BDBM322285
PNG
(5-fluoro-N-(1'-azaspiro[cyclopropane-1,2'-bicyclo[...)
Show SMILES Fc1ccc2sc(cc2c1)C(=O)NC1C2CCN(CC2)C11CC1
Show InChI InChI=1S/C18H19FN2OS/c19-13-1-2-14-12(9-13)10-15(23-14)17(22)20-16-11-3-7-21(8-4-11)18(16)5-6-18/h1-2,9-11,16H,3-8H2,(H,20,22)
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200n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp...


US Patent US10183938 (2019)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (human))
BDBM322436
PNG
((R)-7-ethoxy-N-(1'-azaspiro[cyclopropane-1,2'-bicy...)
Show SMILES CCOc1cccc2cc(sc12)C(=O)N[C@@H]1C2CCN(CC2)C11CC1
Show InChI InChI=1S/C20H24N2O2S/c1-2-24-15-5-3-4-14-12-16(25-17(14)15)19(23)21-18-13-6-10-22(11-7-13)20(18)8-9-20/h3-5,12-13,18H,2,6-11H2,1H3,(H,21,23)/t18-/m1/s1
PDB

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Axovant Sciences GmbH

US Patent


Assay Description
The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp...


US Patent US10183938 (2019)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))
BDBM322434
PNG
((R)-7-(1-methylcyclopropyl)-N-(1'-azaspiro[cyclopr...)
Show SMILES CC1(CC1)c1cccc2cc(sc12)C(=O)N[C@@H]1C2CCN(CC2)C11CC1
Show InChI InChI=1S/C22H26N2OS/c1-21(7-8-21)16-4-2-3-15-13-17(26-18(15)16)20(25)23-19-14-5-11-24(12-6-14)22(19)9-10-22/h2-4,13-14,19H,5-12H2,1H3,(H,23,25)/t19-/m1/s1
PDB

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200n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
[3H]BRL 43694 competition binding assay was performed under contract by Cerep Poitiers, France following the methods described in Hope, A. G et al., ...


US Patent US10183938 (2019)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))
BDBM322406
PNG
((R)-7-cyclopropyl-N-(1'-azaspiro[cyclopropane-1,2'...)
Show SMILES O=C(N[C@@H]1C2CCN(CC2)C11CC1)c1cc2cccc(C3CC3)c2s1
Show InChI InChI=1S/C21H24N2OS/c24-20(22-19-14-6-10-23(11-7-14)21(19)8-9-21)17-12-15-2-1-3-16(13-4-5-13)18(15)25-17/h1-3,12-14,19H,4-11H2,(H,22,24)/t19-/m1/s1
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200n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
[3H]BRL 43694 competition binding assay was performed under contract by Cerep Poitiers, France following the methods described in Hope, A. G et al., ...


US Patent US10183938 (2019)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (human))
BDBM322298
PNG
(6-cyclopropyl-N-(1''-azaspiro[cyclopropane-1,2''-b...)
Show SMILES O=C(NC1C2CCN(CC2)C11CC1)c1cc2ccc(cc2s1)C1CC1
Show InChI InChI=1S/C21H24N2OS/c24-20(22-19-14-5-9-23(10-6-14)21(19)7-8-21)18-12-16-4-3-15(13-1-2-13)11-17(16)25-18/h3-4,11-14,19H,1-2,5-10H2,(H,22,24)
PDB

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210n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp...


US Patent US10183938 (2019)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (human))
BDBM322438
PNG
((R)-6-chloro-7-methoxy-N-(1'-azaspiro[cyclopropane...)
Show SMILES COc1c(Cl)ccc2cc(sc12)C(=O)N[C@@H]1C2CCN(CC2)C11CC1
Show InChI InChI=1S/C19H21ClN2O2S/c1-24-15-13(20)3-2-12-10-14(25-16(12)15)18(23)21-17-11-4-8-22(9-5-11)19(17)6-7-19/h2-3,10-11,17H,4-9H2,1H3,(H,21,23)/t17-/m1/s1
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220n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp...


US Patent US10183938 (2019)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (human))
BDBM322437
PNG
((R)-7-isopropoxy-N-(1'-azaspiro[cyclopropane-1,2'-...)
Show SMILES CC(C)Oc1cccc2cc(sc12)C(=O)N[C@@H]1C2CCN(CC2)C11CC1
Show InChI InChI=1S/C21H26N2O2S/c1-13(2)25-16-5-3-4-15-12-17(26-18(15)16)20(24)22-19-14-6-10-23(11-7-14)21(19)8-9-21/h3-5,12-14,19H,6-11H2,1-2H3,(H,22,24)/t19-/m1/s1
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220n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp...


US Patent US10183938 (2019)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (human))
BDBM322282
PNG
(6-fluoro-N-(1'-azaspiro[cyclopropane-1,2'-bicyclo[...)
Show SMILES Fc1ccc2cc(sc2c1)C(=O)NC1C2CCN(CC2)C11CC1
Show InChI InChI=1S/C18H19FN2OS/c19-13-2-1-12-9-15(23-14(12)10-13)17(22)20-16-11-3-7-21(8-4-11)18(16)5-6-18/h1-2,9-11,16H,3-8H2,(H,20,22)
PDB

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220n/an/an/an/an/an/an/an/a



Axovant Sciences GmbH

US Patent


Assay Description
The ability of compounds to displace binding of radioactive ligands from human α7 nAChR was determined, as a measure of the affinity of the comp...


US Patent US10183938 (2019)

More data for this
Ligand-Target Pair
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