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Compile Data Set for Download or QSAR

Found 426 hits from Axxam S.P.A.   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM267123
PNG
(2-chloro-N-[2-(4,4-difluoropiperidin-1-yl)-2-(1,3-...)
Show SMILES Cc1cccc(Cl)c1C(=O)NCC(N1CCC(F)(F)CC1)c1cncs1
Show InChI InChI=1S/C18H20ClF2N3OS/c1-12-3-2-4-13(19)16(12)17(25)23-9-14(15-10-22-11-26-15)24-7-5-18(20,21)6-8-24/h2-4,10-11,14H,5-9H2,1H3,(H,23,25)
PDB

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n/an/a 8n/an/an/an/an/an/a



Axxam S.P.A.

US Patent


Assay Description
Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...


US Patent US9718812 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM267123
PNG
(2-chloro-N-[2-(4,4-difluoropiperidin-1-yl)-2-(1,3-...)
Show SMILES Cc1cccc(Cl)c1C(=O)NCC(N1CCC(F)(F)CC1)c1cncs1
Show InChI InChI=1S/C18H20ClF2N3OS/c1-12-3-2-4-13(19)16(12)17(25)23-9-14(15-10-22-11-26-15)24-7-5-18(20,21)6-8-24/h2-4,10-11,14H,5-9H2,1H3,(H,23,25)
PDB

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Axxam S.P.A.

US Patent


Assay Description
Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...


US Patent US10167281 (2019)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM267120
PNG
(2-chloro-N-[2-(4,4-difluoropiperidin-1-yl)-2-[2-(t...)
Show SMILES Fc1cccc(Cl)c1C(=O)NCC(N1CCC(F)(F)CC1)c1cnc(s1)C(F)(F)F
Show InChI InChI=1S/C18H16ClF6N3OS/c19-10-2-1-3-11(20)14(10)15(29)26-8-12(28-6-4-17(21,22)5-7-28)13-9-27-16(30-13)18(23,24)25/h1-3,9,12H,4-8H2,(H,26,29)
PDB

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Axxam S.P.A.

US Patent


Assay Description
YO-PROŽ-1 is a fluorescent DNA-binding dye with a MW of 374 Da (Molecular Probes, cat. Y3603). This method is based upon the presumed ability of YO-P...


US Patent US9718812 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM267120
PNG
(2-chloro-N-[2-(4,4-difluoropiperidin-1-yl)-2-[2-(t...)
Show SMILES Fc1cccc(Cl)c1C(=O)NCC(N1CCC(F)(F)CC1)c1cnc(s1)C(F)(F)F
Show InChI InChI=1S/C18H16ClF6N3OS/c19-10-2-1-3-11(20)14(10)15(29)26-8-12(28-6-4-17(21,22)5-7-28)13-9-27-16(30-13)18(23,24)25/h1-3,9,12H,4-8H2,(H,26,29)
PDB

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Axxam S.P.A.

US Patent


Assay Description
YO-PROŽ-1 is a fluorescent DNA-binding dye with a MW of 374 Da (Molecular Probes, cat. Y3603). This method is based upon the presumed ability of YO-P...


US Patent US10167281 (2019)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM267176
PNG
(N-[2-(4,4-difluoropiperidin-1-yl)-2-(1,3-oxazol-5-...)
Show SMILES Cc1cccc(C)c1C(=O)NCC(N1CCC(F)(F)CC1)c1cnco1
Show InChI InChI=1S/C19H23F2N3O2/c1-13-4-3-5-14(2)17(13)18(25)23-10-15(16-11-22-12-26-16)24-8-6-19(20,21)7-9-24/h3-5,11-12,15H,6-10H2,1-2H3,(H,23,25)
PDB

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Axxam S.P.A.

US Patent


Assay Description
Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...


US Patent US10167281 (2019)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM267168
PNG
(2-chloro-N-[2-(4,4-difluoropiperidin-1-yl)-2-(2-me...)
Show SMILES Cc1ncc(s1)C(CNC(=O)c1c(C)cccc1Cl)N1CCC(F)(F)CC1
Show InChI InChI=1S/C19H22ClF2N3OS/c1-12-4-3-5-14(20)17(12)18(26)24-10-15(16-11-23-13(2)27-16)25-8-6-19(21,22)7-9-25/h3-5,11,15H,6-10H2,1-2H3,(H,24,26)
PDB

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Axxam S.P.A.

US Patent


Assay Description
YO-PROŽ-1 is a fluorescent DNA-binding dye with a MW of 374 Da (Molecular Probes, cat. Y3603). This method is based upon the presumed ability of YO-P...


US Patent US9718812 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM267176
PNG
(N-[2-(4,4-difluoropiperidin-1-yl)-2-(1,3-oxazol-5-...)
Show SMILES Cc1cccc(C)c1C(=O)NCC(N1CCC(F)(F)CC1)c1cnco1
Show InChI InChI=1S/C19H23F2N3O2/c1-13-4-3-5-14(2)17(13)18(25)23-10-15(16-11-22-12-26-16)24-8-6-19(20,21)7-9-24/h3-5,11-12,15H,6-10H2,1-2H3,(H,23,25)
PDB

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Axxam S.P.A.

US Patent


Assay Description
Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...


US Patent US9718812 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM267168
PNG
(2-chloro-N-[2-(4,4-difluoropiperidin-1-yl)-2-(2-me...)
Show SMILES Cc1ncc(s1)C(CNC(=O)c1c(C)cccc1Cl)N1CCC(F)(F)CC1
Show InChI InChI=1S/C19H22ClF2N3OS/c1-12-4-3-5-14(20)17(12)18(26)24-10-15(16-11-23-13(2)27-16)25-8-6-19(21,22)7-9-25/h3-5,11,15H,6-10H2,1-2H3,(H,24,26)
PDB

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Axxam S.P.A.

US Patent


Assay Description
YO-PROŽ-1 is a fluorescent DNA-binding dye with a MW of 374 Da (Molecular Probes, cat. Y3603). This method is based upon the presumed ability of YO-P...


US Patent US10167281 (2019)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM267170
PNG
(N-[2-(4,4-difluoropiperidin-1-yl)-2-(2-methyl-1,3-...)
Show SMILES Cc1ncc(s1)C(CNC(=O)c1c(C)cccc1C)N1CCC(F)(F)CC1
Show InChI InChI=1S/C20H25F2N3OS/c1-13-5-4-6-14(2)18(13)19(26)24-11-16(17-12-23-15(3)27-17)25-9-7-20(21,22)8-10-25/h4-6,12,16H,7-11H2,1-3H3,(H,24,26)
PDB

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Axxam S.P.A.

US Patent


Assay Description
YO-PROŽ-1 is a fluorescent DNA-binding dye with a MW of 374 Da (Molecular Probes, cat. Y3603). This method is based upon the presumed ability of YO-P...


US Patent US10167281 (2019)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM267170
PNG
(N-[2-(4,4-difluoropiperidin-1-yl)-2-(2-methyl-1,3-...)
Show SMILES Cc1ncc(s1)C(CNC(=O)c1c(C)cccc1C)N1CCC(F)(F)CC1
Show InChI InChI=1S/C20H25F2N3OS/c1-13-5-4-6-14(2)18(13)19(26)24-11-16(17-12-23-15(3)27-17)25-9-7-20(21,22)8-10-25/h4-6,12,16H,7-11H2,1-3H3,(H,24,26)
PDB

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Axxam S.P.A.

US Patent


Assay Description
YO-PROŽ-1 is a fluorescent DNA-binding dye with a MW of 374 Da (Molecular Probes, cat. Y3603). This method is based upon the presumed ability of YO-P...


US Patent US9718812 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM267201
PNG
(2-chloro-N-[2-(4,4-difluoropiperidin-1-yl)-2-(2-me...)
Show SMILES Cc1ncc(s1)C(CNC(=O)c1cc(ccc1Cl)-c1ncc(F)cn1)N1CCC(F)(F)CC1
Show InChI InChI=1S/C22H21ClF3N5OS/c1-13-27-12-19(33-13)18(31-6-4-22(25,26)5-7-31)11-30-21(32)16-8-14(2-3-17(16)23)20-28-9-15(24)10-29-20/h2-3,8-10,12,18H,4-7,11H2,1H3,(H,30,32)
PDB

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Axxam S.P.A.

US Patent


Assay Description
YO-PROŽ-1 is a fluorescent DNA-binding dye with a MW of 374 Da (Molecular Probes, cat. Y3603). This method is based upon the presumed ability of YO-P...


US Patent US10167281 (2019)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM267212
PNG
(2-chloro-N-[2-(3,3-difluoropiperidin-1-yl)-2-(4-me...)
Show SMILES Cc1ncsc1C(CNC(=O)c1cc(ccc1Cl)-c1ncc(F)cn1)N1CCCC(F)(F)C1
Show InChI InChI=1S/C22H21ClF3N5OS/c1-13-19(33-12-30-13)18(31-6-2-5-22(25,26)11-31)10-29-21(32)16-7-14(3-4-17(16)23)20-27-8-15(24)9-28-20/h3-4,7-9,12,18H,2,5-6,10-11H2,1H3,(H,29,32)
PDB

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Axxam S.P.A.

US Patent


Assay Description
Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...


US Patent US10167281 (2019)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM267223
PNG
(2-chloro-N-{2-[4-(difluoromethyl)-1,3-thiazol-5-yl...)
Show SMILES FC(F)c1ncsc1C(CNC(=O)c1c(F)cccc1Cl)N1CCOCC1
Show InChI InChI=1S/C17H17ClF3N3O2S/c18-10-2-1-3-11(19)13(10)17(25)22-8-12(24-4-6-26-7-5-24)15-14(16(20)21)23-9-27-15/h1-3,9,12,16H,4-8H2,(H,22,25)
PDB

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Axxam S.P.A.

US Patent


Assay Description
Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...


US Patent US9718812 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM267215
PNG
((+)-2-chloro-N-[2-(4,4-difluoro-piperidin-1-yl)-2-...)
Show SMILES Cc1ncc(s1)C(CNC(=O)c1cc(ccc1Cl)-c1ncc(F)cn1)N1CCC(F)(F)CC1
Show InChI InChI=1S/C22H21ClF3N5OS/c1-13-27-12-19(33-13)18(31-6-4-22(25,26)5-7-31)11-30-21(32)16-8-14(2-3-17(16)23)20-28-9-15(24)10-29-20/h2-3,8-10,12,18H,4-7,11H2,1H3,(H,30,32)
PDB

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Axxam S.P.A.

US Patent


Assay Description
YO-PROŽ-1 is a fluorescent DNA-binding dye with a MW of 374 Da (Molecular Probes, cat. Y3603). This method is based upon the presumed ability of YO-P...


US Patent US9718812 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM267212
PNG
(2-chloro-N-[2-(3,3-difluoropiperidin-1-yl)-2-(4-me...)
Show SMILES Cc1ncsc1C(CNC(=O)c1cc(ccc1Cl)-c1ncc(F)cn1)N1CCCC(F)(F)C1
Show InChI InChI=1S/C22H21ClF3N5OS/c1-13-19(33-12-30-13)18(31-6-2-5-22(25,26)11-31)10-29-21(32)16-7-14(3-4-17(16)23)20-27-8-15(24)9-28-20/h3-4,7-9,12,18H,2,5-6,10-11H2,1H3,(H,29,32)
PDB

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Axxam S.P.A.

US Patent


Assay Description
Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...


US Patent US9718812 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM267223
PNG
(2-chloro-N-{2-[4-(difluoromethyl)-1,3-thiazol-5-yl...)
Show SMILES FC(F)c1ncsc1C(CNC(=O)c1c(F)cccc1Cl)N1CCOCC1
Show InChI InChI=1S/C17H17ClF3N3O2S/c18-10-2-1-3-11(19)13(10)17(25)22-8-12(24-4-6-26-7-5-24)15-14(16(20)21)23-9-27-15/h1-3,9,12,16H,4-8H2,(H,22,25)
PDB

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Axxam S.P.A.

US Patent


Assay Description
Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...


US Patent US10167281 (2019)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM267201
PNG
(2-chloro-N-[2-(4,4-difluoropiperidin-1-yl)-2-(2-me...)
Show SMILES Cc1ncc(s1)C(CNC(=O)c1cc(ccc1Cl)-c1ncc(F)cn1)N1CCC(F)(F)CC1
Show InChI InChI=1S/C22H21ClF3N5OS/c1-13-27-12-19(33-13)18(31-6-4-22(25,26)5-7-31)11-30-21(32)16-8-14(2-3-17(16)23)20-28-9-15(24)10-29-20/h2-3,8-10,12,18H,4-7,11H2,1H3,(H,30,32)
PDB

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Axxam S.P.A.

US Patent


Assay Description
YO-PROŽ-1 is a fluorescent DNA-binding dye with a MW of 374 Da (Molecular Probes, cat. Y3603). This method is based upon the presumed ability of YO-P...


US Patent US10167281 (2019)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM267121
PNG
(N-[2-(4,4-difluoropiperidin-1-yl)-2-(1,3-thiazol-5...)
Show SMILES Cc1cccc(C)c1C(=O)NCC(N1CCC(F)(F)CC1)c1cncs1
Show InChI InChI=1S/C19H23F2N3OS/c1-13-4-3-5-14(2)17(13)18(25)23-10-15(16-11-22-12-26-16)24-8-6-19(20,21)7-9-24/h3-5,11-12,15H,6-10H2,1-2H3,(H,23,25)
PDB

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Axxam S.P.A.

US Patent


Assay Description
YO-PROŽ-1 is a fluorescent DNA-binding dye with a MW of 374 Da (Molecular Probes, cat. Y3603). This method is based upon the presumed ability of YO-P...


US Patent US9718812 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM267121
PNG
(N-[2-(4,4-difluoropiperidin-1-yl)-2-(1,3-thiazol-5...)
Show SMILES Cc1cccc(C)c1C(=O)NCC(N1CCC(F)(F)CC1)c1cncs1
Show InChI InChI=1S/C19H23F2N3OS/c1-13-4-3-5-14(2)17(13)18(25)23-10-15(16-11-22-12-26-16)24-8-6-19(20,21)7-9-24/h3-5,11-12,15H,6-10H2,1-2H3,(H,23,25)
PDB

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Axxam S.P.A.

US Patent


Assay Description
YO-PROŽ-1 is a fluorescent DNA-binding dye with a MW of 374 Da (Molecular Probes, cat. Y3603). This method is based upon the presumed ability of YO-P...


US Patent US10167281 (2019)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM267217
PNG
((-)-2-chloro-N-[2-(4,4-difluoro-piperidin-1-yl)-2-...)
Show SMILES Cc1ncc(s1)C(CNC(=O)c1cc(ccc1Cl)-c1ncc(F)cn1)N1CCC(F)(F)CC1
Show InChI InChI=1S/C22H21ClF3N5OS/c1-13-27-12-19(33-13)18(31-6-4-22(25,26)5-7-31)11-30-21(32)16-8-14(2-3-17(16)23)20-28-9-15(24)10-29-20/h2-3,8-10,12,18H,4-7,11H2,1H3,(H,30,32)
PDB

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Axxam S.P.A.

US Patent


Assay Description
YO-PROŽ-1 is a fluorescent DNA-binding dye with a MW of 374 Da (Molecular Probes, cat. Y3603). This method is based upon the presumed ability of YO-P...


US Patent US9718812 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM267223
PNG
(2-chloro-N-{2-[4-(difluoromethyl)-1,3-thiazol-5-yl...)
Show SMILES FC(F)c1ncsc1C(CNC(=O)c1c(F)cccc1Cl)N1CCOCC1
Show InChI InChI=1S/C17H17ClF3N3O2S/c18-10-2-1-3-11(19)13(10)17(25)22-8-12(24-4-6-26-7-5-24)15-14(16(20)21)23-9-27-15/h1-3,9,12,16H,4-8H2,(H,22,25)
PDB

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Axxam S.P.A.

US Patent


Assay Description
YO-PROŽ-1 is a fluorescent DNA-binding dye with a MW of 374 Da (Molecular Probes, cat. Y3603). This method is based upon the presumed ability of YO-P...


US Patent US9718812 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM267223
PNG
(2-chloro-N-{2-[4-(difluoromethyl)-1,3-thiazol-5-yl...)
Show SMILES FC(F)c1ncsc1C(CNC(=O)c1c(F)cccc1Cl)N1CCOCC1
Show InChI InChI=1S/C17H17ClF3N3O2S/c18-10-2-1-3-11(19)13(10)17(25)22-8-12(24-4-6-26-7-5-24)15-14(16(20)21)23-9-27-15/h1-3,9,12,16H,4-8H2,(H,22,25)
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Axxam S.P.A.

US Patent


Assay Description
YO-PROŽ-1 is a fluorescent DNA-binding dye with a MW of 374 Da (Molecular Probes, cat. Y3603). This method is based upon the presumed ability of YO-P...


US Patent US10167281 (2019)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM267219
PNG
(US10167281, Compound 129 | US9718812, 129)
Show SMILES FC(F)c1ncsc1C(CNC(=O)c1cc(ccc1Cl)-c1ncc(F)cn1)N1CCOCC1
Show InChI InChI=1S/C21H19ClF3N5O2S/c22-15-2-1-12(20-26-8-13(23)9-27-20)7-14(15)21(31)28-10-16(30-3-5-32-6-4-30)18-17(19(24)25)29-11-33-18/h1-2,7-9,11,16,19H,3-6,10H2,(H,28,31)
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Axxam S.P.A.

US Patent


Assay Description
YO-PROŽ-1 is a fluorescent DNA-binding dye with a MW of 374 Da (Molecular Probes, cat. Y3603). This method is based upon the presumed ability of YO-P...


US Patent US10167281 (2019)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM267121
PNG
(N-[2-(4,4-difluoropiperidin-1-yl)-2-(1,3-thiazol-5...)
Show SMILES Cc1cccc(C)c1C(=O)NCC(N1CCC(F)(F)CC1)c1cncs1
Show InChI InChI=1S/C19H23F2N3OS/c1-13-4-3-5-14(2)17(13)18(25)23-10-15(16-11-22-12-26-16)24-8-6-19(20,21)7-9-24/h3-5,11-12,15H,6-10H2,1-2H3,(H,23,25)
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Axxam S.P.A.

US Patent


Assay Description
Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...


US Patent US9718812 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM267219
PNG
(US10167281, Compound 129 | US9718812, 129)
Show SMILES FC(F)c1ncsc1C(CNC(=O)c1cc(ccc1Cl)-c1ncc(F)cn1)N1CCOCC1
Show InChI InChI=1S/C21H19ClF3N5O2S/c22-15-2-1-12(20-26-8-13(23)9-27-20)7-14(15)21(31)28-10-16(30-3-5-32-6-4-30)18-17(19(24)25)29-11-33-18/h1-2,7-9,11,16,19H,3-6,10H2,(H,28,31)
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Axxam S.P.A.

US Patent


Assay Description
YO-PROŽ-1 is a fluorescent DNA-binding dye with a MW of 374 Da (Molecular Probes, cat. Y3603). This method is based upon the presumed ability of YO-P...


US Patent US9718812 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM267121
PNG
(N-[2-(4,4-difluoropiperidin-1-yl)-2-(1,3-thiazol-5...)
Show SMILES Cc1cccc(C)c1C(=O)NCC(N1CCC(F)(F)CC1)c1cncs1
Show InChI InChI=1S/C19H23F2N3OS/c1-13-4-3-5-14(2)17(13)18(25)23-10-15(16-11-22-12-26-16)24-8-6-19(20,21)7-9-24/h3-5,11-12,15H,6-10H2,1-2H3,(H,23,25)
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Axxam S.P.A.

US Patent


Assay Description
Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...


US Patent US10167281 (2019)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM267109
PNG
(2-chloro-N-[2-(4,4-difluoro-piperidin-1-yl)-2-(1,3...)
Show SMILES Fc1cccc(Cl)c1C(=O)NCC(N1CCC(F)(F)CC1)c1cncs1
Show InChI InChI=1S/C17H17ClF3N3OS/c18-11-2-1-3-12(19)15(11)16(25)23-8-13(14-9-22-10-26-14)24-6-4-17(20,21)5-7-24/h1-3,9-10,13H,4-8H2,(H,23,25)
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Axxam S.P.A.

US Patent


Assay Description
Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...


US Patent US10167281 (2019)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM267168
PNG
(2-chloro-N-[2-(4,4-difluoropiperidin-1-yl)-2-(2-me...)
Show SMILES Cc1ncc(s1)C(CNC(=O)c1c(C)cccc1Cl)N1CCC(F)(F)CC1
Show InChI InChI=1S/C19H22ClF2N3OS/c1-12-4-3-5-14(20)17(12)18(26)24-10-15(16-11-23-13(2)27-16)25-8-6-19(21,22)7-9-25/h3-5,11,15H,6-10H2,1-2H3,(H,24,26)
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Axxam S.P.A.

US Patent


Assay Description
Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...


US Patent US10167281 (2019)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM267108
PNG
((+)-2-chloro-N-[2-(4,4-difluoropiperidin-1-yl)-2-(...)
Show SMILES Cc1ncsc1C(CNC(=O)c1cc(ccc1Cl)-c1ncc(F)cn1)N1CCC(F)(F)CC1
Show InChI InChI=1S/C22H21ClF3N5OS/c1-13-19(33-12-30-13)18(31-6-4-22(25,26)5-7-31)11-29-21(32)16-8-14(2-3-17(16)23)20-27-9-15(24)10-28-20/h2-3,8-10,12,18H,4-7,11H2,1H3,(H,29,32)
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Axxam S.P.A.

US Patent


Assay Description
YO-PROŽ-1 is a fluorescent DNA-binding dye with a MW of 374 Da (Molecular Probes, cat. Y3603). This method is based upon the presumed ability of YO-P...


US Patent US10167281 (2019)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM267134
PNG
(2-chloro-N-[2-(2-cyclopropyl-1,3-thiazol-5-yl)-2-(...)
Show SMILES Fc1cccc(Cl)c1C(=O)NCC(N1CCC(F)(F)CC1)c1cnc(s1)C1CC1
Show InChI InChI=1S/C20H21ClF3N3OS/c21-13-2-1-3-14(22)17(13)18(28)25-10-15(27-8-6-20(23,24)7-9-27)16-11-26-19(29-16)12-4-5-12/h1-3,11-12,15H,4-10H2,(H,25,28)
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Axxam S.P.A.

US Patent


Assay Description
YO-PROŽ-1 is a fluorescent DNA-binding dye with a MW of 374 Da (Molecular Probes, cat. Y3603). This method is based upon the presumed ability of YO-P...


US Patent US9718812 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM267109
PNG
(2-chloro-N-[2-(4,4-difluoro-piperidin-1-yl)-2-(1,3...)
Show SMILES Fc1cccc(Cl)c1C(=O)NCC(N1CCC(F)(F)CC1)c1cncs1
Show InChI InChI=1S/C17H17ClF3N3OS/c18-11-2-1-3-12(19)15(11)16(25)23-8-13(14-9-22-10-26-14)24-6-4-17(20,21)5-7-24/h1-3,9-10,13H,4-8H2,(H,23,25)
PDB

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Axxam S.P.A.

US Patent


Assay Description
Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...


US Patent US9718812 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM267168
PNG
(2-chloro-N-[2-(4,4-difluoropiperidin-1-yl)-2-(2-me...)
Show SMILES Cc1ncc(s1)C(CNC(=O)c1c(C)cccc1Cl)N1CCC(F)(F)CC1
Show InChI InChI=1S/C19H22ClF2N3OS/c1-12-4-3-5-14(20)17(12)18(26)24-10-15(16-11-23-13(2)27-16)25-8-6-19(21,22)7-9-25/h3-5,11,15H,6-10H2,1-2H3,(H,24,26)
PDB

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Axxam S.P.A.

US Patent


Assay Description
Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...


US Patent US9718812 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM267108
PNG
((+)-2-chloro-N-[2-(4,4-difluoropiperidin-1-yl)-2-(...)
Show SMILES Cc1ncsc1C(CNC(=O)c1cc(ccc1Cl)-c1ncc(F)cn1)N1CCC(F)(F)CC1
Show InChI InChI=1S/C22H21ClF3N5OS/c1-13-19(33-12-30-13)18(31-6-4-22(25,26)5-7-31)11-29-21(32)16-8-14(2-3-17(16)23)20-27-9-15(24)10-28-20/h2-3,8-10,12,18H,4-7,11H2,1H3,(H,29,32)
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Axxam S.P.A.

US Patent


Assay Description
YO-PROŽ-1 is a fluorescent DNA-binding dye with a MW of 374 Da (Molecular Probes, cat. Y3603). This method is based upon the presumed ability of YO-P...


US Patent US9718812 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM267134
PNG
(2-chloro-N-[2-(2-cyclopropyl-1,3-thiazol-5-yl)-2-(...)
Show SMILES Fc1cccc(Cl)c1C(=O)NCC(N1CCC(F)(F)CC1)c1cnc(s1)C1CC1
Show InChI InChI=1S/C20H21ClF3N3OS/c21-13-2-1-3-14(22)17(13)18(28)25-10-15(27-8-6-20(23,24)7-9-27)16-11-26-19(29-16)12-4-5-12/h1-3,11-12,15H,4-10H2,(H,25,28)
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Axxam S.P.A.

US Patent


Assay Description
YO-PROŽ-1 is a fluorescent DNA-binding dye with a MW of 374 Da (Molecular Probes, cat. Y3603). This method is based upon the presumed ability of YO-P...


US Patent US10167281 (2019)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM267102
PNG
(2-chloro-N-[2-(4,4-difluoropiperidin-1-yl)-2-(4-me...)
Show SMILES Cc1ncsc1C(CNC(=O)c1cc(ccc1Cl)-c1cnccn1)N1CCC(F)(F)CC1
Show InChI InChI=1S/C22H22ClF2N5OS/c1-14-20(32-13-29-14)19(30-8-4-22(24,25)5-9-30)12-28-21(31)16-10-15(2-3-17(16)23)18-11-26-6-7-27-18/h2-3,6-7,10-11,13,19H,4-5,8-9,12H2,1H3,(H,28,31)
PDB

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Axxam S.P.A.

US Patent


Assay Description
Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...


US Patent US10167281 (2019)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM267108
PNG
((+)-2-chloro-N-[2-(4,4-difluoropiperidin-1-yl)-2-(...)
Show SMILES Cc1ncsc1C(CNC(=O)c1cc(ccc1Cl)-c1ncc(F)cn1)N1CCC(F)(F)CC1
Show InChI InChI=1S/C22H21ClF3N5OS/c1-13-19(33-12-30-13)18(31-6-4-22(25,26)5-7-31)11-29-21(32)16-8-14(2-3-17(16)23)20-27-9-15(24)10-28-20/h2-3,8-10,12,18H,4-7,11H2,1H3,(H,29,32)
PDB

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Axxam S.P.A.

US Patent


Assay Description
Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...


US Patent US10167281 (2019)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM267170
PNG
(N-[2-(4,4-difluoropiperidin-1-yl)-2-(2-methyl-1,3-...)
Show SMILES Cc1ncc(s1)C(CNC(=O)c1c(C)cccc1C)N1CCC(F)(F)CC1
Show InChI InChI=1S/C20H25F2N3OS/c1-13-5-4-6-14(2)18(13)19(26)24-11-16(17-12-23-15(3)27-17)25-9-7-20(21,22)8-10-25/h4-6,12,16H,7-11H2,1-3H3,(H,24,26)
PDB

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Axxam S.P.A.

US Patent


Assay Description
Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...


US Patent US10167281 (2019)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM267133
PNG
(2-chloro-N-[2-(4,4-difluoropiperidin-1-yl)-2-(1,3-...)
Show SMILES Fc1cnc(nc1)-c1ccc(Cl)c(c1)C(=O)NCC(N1CCC(F)(F)CC1)c1cncs1
Show InChI InChI=1S/C21H19ClF3N5OS/c22-16-2-1-13(19-27-8-14(23)9-28-19)7-15(16)20(31)29-10-17(18-11-26-12-32-18)30-5-3-21(24,25)4-6-30/h1-2,7-9,11-12,17H,3-6,10H2,(H,29,31)
PDB

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Axxam S.P.A.

US Patent


Assay Description
YO-PROŽ-1 is a fluorescent DNA-binding dye with a MW of 374 Da (Molecular Probes, cat. Y3603). This method is based upon the presumed ability of YO-P...


US Patent US9718812 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM267133
PNG
(2-chloro-N-[2-(4,4-difluoropiperidin-1-yl)-2-(1,3-...)
Show SMILES Fc1cnc(nc1)-c1ccc(Cl)c(c1)C(=O)NCC(N1CCC(F)(F)CC1)c1cncs1
Show InChI InChI=1S/C21H19ClF3N5OS/c22-16-2-1-13(19-27-8-14(23)9-28-19)7-15(16)20(31)29-10-17(18-11-26-12-32-18)30-5-3-21(24,25)4-6-30/h1-2,7-9,11-12,17H,3-6,10H2,(H,29,31)
PDB

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Axxam S.P.A.

US Patent


Assay Description
YO-PROŽ-1 is a fluorescent DNA-binding dye with a MW of 374 Da (Molecular Probes, cat. Y3603). This method is based upon the presumed ability of YO-P...


US Patent US10167281 (2019)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM267108
PNG
((+)-2-chloro-N-[2-(4,4-difluoropiperidin-1-yl)-2-(...)
Show SMILES Cc1ncsc1C(CNC(=O)c1cc(ccc1Cl)-c1ncc(F)cn1)N1CCC(F)(F)CC1
Show InChI InChI=1S/C22H21ClF3N5OS/c1-13-19(33-12-30-13)18(31-6-4-22(25,26)5-7-31)11-29-21(32)16-8-14(2-3-17(16)23)20-27-9-15(24)10-28-20/h2-3,8-10,12,18H,4-7,11H2,1H3,(H,29,32)
PDB

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Axxam S.P.A.

US Patent


Assay Description
Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...


US Patent US9718812 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM267170
PNG
(N-[2-(4,4-difluoropiperidin-1-yl)-2-(2-methyl-1,3-...)
Show SMILES Cc1ncc(s1)C(CNC(=O)c1c(C)cccc1C)N1CCC(F)(F)CC1
Show InChI InChI=1S/C20H25F2N3OS/c1-13-5-4-6-14(2)18(13)19(26)24-11-16(17-12-23-15(3)27-17)25-9-7-20(21,22)8-10-25/h4-6,12,16H,7-11H2,1-3H3,(H,24,26)
PDB

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Axxam S.P.A.

US Patent


Assay Description
Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...


US Patent US9718812 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM267102
PNG
(2-chloro-N-[2-(4,4-difluoropiperidin-1-yl)-2-(4-me...)
Show SMILES Cc1ncsc1C(CNC(=O)c1cc(ccc1Cl)-c1cnccn1)N1CCC(F)(F)CC1
Show InChI InChI=1S/C22H22ClF2N5OS/c1-14-20(32-13-29-14)19(30-8-4-22(24,25)5-9-30)12-28-21(31)16-10-15(2-3-17(16)23)18-11-26-6-7-27-18/h2-3,6-7,10-11,13,19H,4-5,8-9,12H2,1H3,(H,28,31)
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Axxam S.P.A.

US Patent


Assay Description
Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...


US Patent US9718812 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM267135
PNG
(N-[2-(4,4-difluoropiperidin-1-yl)-2-(1,3-thiazol-5...)
Show SMILES COc1cccc(C(=O)NCC(N2CCC(F)(F)CC2)c2cncs2)c1OC
Show InChI InChI=1S/C19H23F2N3O3S/c1-26-15-5-3-4-13(17(15)27-2)18(25)23-10-14(16-11-22-12-28-16)24-8-6-19(20,21)7-9-24/h3-5,11-12,14H,6-10H2,1-2H3,(H,23,25)
PDB

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US Patent
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Axxam S.P.A.

US Patent


Assay Description
Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...


US Patent US10167281 (2019)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM267151
PNG
(2-chloro-N-[2-(4,4-difluoropiperidin-1-yl)-2-(4-me...)
Show SMILES Cc1ncsc1C(CNC(=O)c1c(F)cccc1Cl)N1CCC(F)(F)CC1
Show InChI InChI=1S/C18H19ClF3N3OS/c1-11-16(27-10-24-11)14(25-7-5-18(21,22)6-8-25)9-23-17(26)15-12(19)3-2-4-13(15)20/h2-4,10,14H,5-9H2,1H3,(H,23,26)
PDB

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Axxam S.P.A.

US Patent


Assay Description
Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...


US Patent US9718812 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM267135
PNG
(N-[2-(4,4-difluoropiperidin-1-yl)-2-(1,3-thiazol-5...)
Show SMILES COc1cccc(C(=O)NCC(N2CCC(F)(F)CC2)c2cncs2)c1OC
Show InChI InChI=1S/C19H23F2N3O3S/c1-26-15-5-3-4-13(17(15)27-2)18(25)23-10-14(16-11-22-12-28-16)24-8-6-19(20,21)7-9-24/h3-5,11-12,14H,6-10H2,1-2H3,(H,23,25)
PDB

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US Patent
n/an/a 31n/an/an/an/an/an/a



Axxam S.P.A.

US Patent


Assay Description
Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...


US Patent US9718812 (2017)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM267151
PNG
(2-chloro-N-[2-(4,4-difluoropiperidin-1-yl)-2-(4-me...)
Show SMILES Cc1ncsc1C(CNC(=O)c1c(F)cccc1Cl)N1CCC(F)(F)CC1
Show InChI InChI=1S/C18H19ClF3N3OS/c1-11-16(27-10-24-11)14(25-7-5-18(21,22)6-8-25)9-23-17(26)15-12(19)3-2-4-13(15)20/h2-4,10,14H,5-9H2,1H3,(H,23,26)
PDB

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Axxam S.P.A.

US Patent


Assay Description
Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...


US Patent US10167281 (2019)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM267190
PNG
(N-{2-[2-(4,4-difluorocyclohexyl)-1,3-thiazol-5-yl]...)
Show SMILES FC1(F)CCC(CC1)c1ncc(s1)C(CNC(=O)c1cccc2ncccc12)N1CCOCC1
Show InChI InChI=1S/C25H28F2N4O2S/c26-25(27)8-6-17(7-9-25)24-30-16-22(34-24)21(31-11-13-33-14-12-31)15-29-23(32)19-3-1-5-20-18(19)4-2-10-28-20/h1-5,10,16-17,21H,6-9,11-15H2,(H,29,32)
PDB

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Axxam S.P.A.

US Patent


Assay Description
YO-PROŽ-1 is a fluorescent DNA-binding dye with a MW of 374 Da (Molecular Probes, cat. Y3603). This method is based upon the presumed ability of YO-P...


US Patent US10167281 (2019)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM267098
PNG
(N-[2-(4,4-difluoropiperidin-1-yl)-2-(4-methyl-1,3-...)
Show SMILES Cc1ncsc1C(CNC(=O)c1cc(ccc1F)-c1ncc(F)cn1)N1CCC(F)(F)CC1
Show InChI InChI=1S/C22H21F4N5OS/c1-13-19(33-12-30-13)18(31-6-4-22(25,26)5-7-31)11-29-21(32)16-8-14(2-3-17(16)24)20-27-9-15(23)10-28-20/h2-3,8-10,12,18H,4-7,11H2,1H3,(H,29,32)
PDB

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Axxam S.P.A.

US Patent


Assay Description
Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...


US Patent US10167281 (2019)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM267125
PNG
(5-amino-2-chloro-N-[2-(4,4-difluoropiperidin-1-yl)...)
Show SMILES Nc1ccc(Cl)c(c1)C(=O)NCC(N1CCC(F)(F)CC1)c1cncs1
Show InChI InChI=1S/C17H19ClF2N4OS/c18-13-2-1-11(21)7-12(13)16(25)23-8-14(15-9-22-10-26-15)24-5-3-17(19,20)4-6-24/h1-2,7,9-10,14H,3-6,8,21H2,(H,23,25)
PDB

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Axxam S.P.A.

US Patent


Assay Description
Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...


US Patent US10167281 (2019)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM267156
PNG
(N-{2-[2-(2,4-difluorophenyl)morpholin-4-yl]-2-(4-m...)
Show SMILES Cc1ncsc1C(CNC(=O)c1cccc2ncccc12)N1CCOC(C1)c1ccc(F)cc1F
Show InChI InChI=1S/C26H24F2N4O2S/c1-16-25(35-15-31-16)23(13-30-26(33)19-4-2-6-22-18(19)5-3-9-29-22)32-10-11-34-24(14-32)20-8-7-17(27)12-21(20)28/h2-9,12,15,23-24H,10-11,13-14H2,1H3,(H,30,33)
PDB

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UniProtKB/SwissProt

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Axxam S.P.A.

US Patent


Assay Description
Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...


US Patent US10167281 (2019)

More data for this
Ligand-Target Pair
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