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Compile Data Set for Download or QSAR

Found 159 hits from BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312567
PNG
(1-[4-(6-Methoxy-7,8-dimethyl-3-phenylimidazo[1,2-b...)
Show SMILES COc1nn2c(c(nc2c(C)c1C)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1
Show InChI InChI=1S/C25H26N4O/c1-16-17(2)24(30-3)28-29-22(19-8-5-4-6-9-19)21(27-23(16)29)18-10-12-20(13-11-18)25(26)14-7-15-25/h4-6,8-13H,7,14-15,26H2,1-3H3
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n/an/a 2.40n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312579
PNG
(US9604989, Example 65)
Show SMILES CNC(=O)c1cc(-c2cc[nH]n2)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C27H25N7O/c1-29-26(35)22-16-20(21-12-15-30-32-21)25-31-23(24(34(25)33-22)18-6-3-2-4-7-18)17-8-10-19(11-9-17)27(28)13-5-14-27/h2-4,6-12,15-16H,5,13-14,28H2,1H3,(H,29,35)(H,30,32)
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n/an/a 2.60n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312522
PNG
(2-[4-(1-Aminocyclobutyl)phenyl]-8-methoxy-3-phenyl...)
Show SMILES COc1cc(nn2c(c(nc12)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1)C(C)=O
Show InChI InChI=1S/C25H24N4O2/c1-16(30)20-15-21(31-2)24-27-22(23(29(24)28-20)18-7-4-3-5-8-18)17-9-11-19(12-10-17)25(26)13-6-14-25/h3-5,7-12,15H,6,13-14,26H2,1-2H3
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n/an/a 2.60n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312579
PNG
(US9604989, Example 65)
Show SMILES CNC(=O)c1cc(-c2cc[nH]n2)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C27H25N7O/c1-29-26(35)22-16-20(21-12-15-30-32-21)25-31-23(24(34(25)33-22)18-6-3-2-4-7-18)17-8-10-19(11-9-17)27(28)13-5-14-27/h2-4,6-12,15-16H,5,13-14,28H2,1H3,(H,29,35)(H,30,32)
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n/an/a 3.10n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312575
PNG
(US9604989, Example 61)
Show SMILES CCOc1cc(nn2c(c(nc12)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1)C(N)=O
Show InChI InChI=1S/C25H25N5O2/c1-2-32-20-15-19(23(26)31)29-30-22(17-7-4-3-5-8-17)21(28-24(20)30)16-9-11-18(12-10-16)25(27)13-6-14-25/h3-5,7-12,15H,2,6,13-14,27H2,1H3,(H2,26,31)
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n/an/a 3.70n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312548
PNG
(US9604989, Example 34)
Show SMILES NC(=O)c1cc(C(N)=O)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C24H22N6O2/c25-21(31)17-13-18(22(26)32)29-30-20(15-5-2-1-3-6-15)19(28-23(17)30)14-7-9-16(10-8-14)24(27)11-4-12-24/h1-3,5-10,13H,4,11-12,27H2,(H2,25,31)(H2,26,32)
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n/an/a 3.90n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312521
PNG
(1-[4-(6,8-Dimethyloxy-3-phenylimidazo[1,2-b]pyrida...)
Show SMILES COc1cc(OC)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C24H24N4O2/c1-29-19-15-20(30-2)27-28-22(17-7-4-3-5-8-17)21(26-23(19)28)16-9-11-18(12-10-16)24(25)13-6-14-24/h3-5,7-12,15H,6,13-14,25H2,1-2H3
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n/an/a 3.90n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312522
PNG
(2-[4-(1-Aminocyclobutyl)phenyl]-8-methoxy-3-phenyl...)
Show SMILES COc1cc(nn2c(c(nc12)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1)C(C)=O
Show InChI InChI=1S/C25H24N4O2/c1-16(30)20-15-21(31-2)24-27-22(23(29(24)28-20)18-7-4-3-5-8-18)17-9-11-19(12-10-17)25(26)13-6-14-25/h3-5,7-12,15H,6,13-14,26H2,1-2H3
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n/an/a 4.10n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312575
PNG
(US9604989, Example 61)
Show SMILES CCOc1cc(nn2c(c(nc12)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1)C(N)=O
Show InChI InChI=1S/C25H25N5O2/c1-2-32-20-15-19(23(26)31)29-30-22(17-7-4-3-5-8-17)21(28-24(20)30)16-9-11-18(12-10-16)25(27)13-6-14-25/h3-5,7-12,15H,2,6,13-14,27H2,1H3,(H2,26,31)
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n/an/a 4.10n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312518
PNG
(1-[4-(6-Methyloxy-3-phenylimidazo[1,2-b]pyridazin-...)
Show SMILES COc1ccc2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C23H22N4O/c1-28-20-13-12-19-25-21(22(27(19)26-20)17-6-3-2-4-7-17)16-8-10-18(11-9-16)23(24)14-5-15-23/h2-4,6-13H,5,14-15,24H2,1H3
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n/an/a 4.20n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312587
PNG
(1-{4-[6-Methoxy-3-phenyl-8-(1H-pyrazol-3-yl)imidaz...)
Show SMILES COc1cc(-c2cc[nH]n2)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C26H24N6O/c1-33-22-16-20(21-12-15-28-30-21)25-29-23(24(32(25)31-22)18-6-3-2-4-7-18)17-8-10-19(11-9-17)26(27)13-5-14-26/h2-4,6-12,15-16H,5,13-14,27H2,1H3,(H,28,30)
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n/an/a 4.30n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312527
PNG
(US9604989, Example 15)
Show SMILES COc1cc(-c2cn[nH]c2)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C26H24N6O/c1-33-22-14-21(19-15-28-29-16-19)25-30-23(24(32(25)31-22)18-6-3-2-4-7-18)17-8-10-20(11-9-17)26(27)12-5-13-26/h2-4,6-11,14-16H,5,12-13,27H2,1H3,(H,28,29)
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n/an/a 4.40n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312578
PNG
(US9604989, Example 64)
Show SMILES CNC(=O)c1cc(OCC2CC2)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C28H29N5O2/c1-30-27(34)22-16-23(35-17-18-8-9-18)26-31-24(25(33(26)32-22)20-6-3-2-4-7-20)19-10-12-21(13-11-19)28(29)14-5-15-28/h2-4,6-7,10-13,16,18H,5,8-9,14-15,17,29H2,1H3,(H,30,34)
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n/an/a 4.80n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312541
PNG
(US9604989, Example 28)
Show SMILES COCCOc1cc(nn2c(c(nc12)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1)C(N)=O
Show InChI InChI=1S/C26H27N5O3/c1-33-14-15-34-21-16-20(24(27)32)30-31-23(18-6-3-2-4-7-18)22(29-25(21)31)17-8-10-19(11-9-17)26(28)12-5-13-26/h2-4,6-11,16H,5,12-15,28H2,1H3,(H2,27,32)
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n/an/a 5n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312517
PNG
(2-[4-(1-Aminocyclobutyl)phenyl]-3-phenylimidazo[1,...)
Show SMILES NC(=O)c1ccc2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C23H21N5O/c24-22(29)18-11-12-19-26-20(21(28(19)27-18)16-5-2-1-3-6-16)15-7-9-17(10-8-15)23(25)13-4-14-23/h1-3,5-12H,4,13-14,25H2,(H2,24,29)
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n/an/a 5.20n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312541
PNG
(US9604989, Example 28)
Show SMILES COCCOc1cc(nn2c(c(nc12)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1)C(N)=O
Show InChI InChI=1S/C26H27N5O3/c1-33-14-15-34-21-16-20(24(27)32)30-31-23(18-6-3-2-4-7-18)22(29-25(21)31)17-8-10-19(11-9-17)26(28)12-5-13-26/h2-4,6-11,16H,5,12-15,28H2,1H3,(H2,27,32)
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n/an/a 5.40n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312539
PNG
(US9604989, Example 26)
Show SMILES CNC(=O)c1cc(OC)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C25H25N5O2/c1-27-24(31)19-15-20(32-2)23-28-21(22(30(23)29-19)17-7-4-3-5-8-17)16-9-11-18(12-10-16)25(26)13-6-14-25/h3-5,7-12,15H,6,13-14,26H2,1-2H3,(H,27,31)
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n/an/a 6.30n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312570
PNG
(Methyl 2-[4-(1-aminocyclobutyl)phenyl]-3-phenyl-8-...)
Show SMILES COC(=O)c1cc(-c2cc[nH]n2)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C27H24N6O2/c1-35-26(34)22-16-20(21-12-15-29-31-21)25-30-23(24(33(25)32-22)18-6-3-2-4-7-18)17-8-10-19(11-9-17)27(28)13-5-14-27/h2-4,6-12,15-16H,5,13-14,28H2,1H3,(H,29,31)
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n/an/a 6.60n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312519
PNG
(1-[4-(6-Bromo-8-methyloxy-3-phenylimidazo[1,2-b]py...)
Show SMILES COc1cc(Br)nn2c(c(nc12)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1
Show InChI InChI=1S/C23H21BrN4O/c1-29-18-14-19(24)27-28-21(16-6-3-2-4-7-16)20(26-22(18)28)15-8-10-17(11-9-15)23(25)12-5-13-23/h2-4,6-11,14H,5,12-13,25H2,1H3
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n/an/a 6.90n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312574
PNG
(US9604989, Example 60)
Show SMILES NC(=O)c1cc(-c2cc[nH]n2)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C26H23N7O/c27-24(34)21-15-19(20-11-14-29-31-20)25-30-22(23(33(25)32-21)17-5-2-1-3-6-17)16-7-9-18(10-8-16)26(28)12-4-13-26/h1-3,5-11,14-15H,4,12-13,28H2,(H2,27,34)(H,29,31)
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n/an/a 7.20n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312534
PNG
(US9604989, Example 22)
Show SMILES CCOc1cc(nn2c(c(nc12)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1)C(=O)NC
Show InChI InChI=1S/C26H27N5O2/c1-3-33-21-16-20(25(32)28-2)30-31-23(18-8-5-4-6-9-18)22(29-24(21)31)17-10-12-19(13-11-17)26(27)14-7-15-26/h4-6,8-13,16H,3,7,14-15,27H2,1-2H3,(H,28,32)
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n/an/a 8n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312567
PNG
(1-[4-(6-Methoxy-7,8-dimethyl-3-phenylimidazo[1,2-b...)
Show SMILES COc1nn2c(c(nc2c(C)c1C)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1
Show InChI InChI=1S/C25H26N4O/c1-16-17(2)24(30-3)28-29-22(19-8-5-4-6-9-19)21(27-23(16)29)18-10-12-20(13-11-18)25(26)14-7-15-25/h4-6,8-13H,7,14-15,26H2,1-3H3
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n/an/a 9.20n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312519
PNG
(1-[4-(6-Bromo-8-methyloxy-3-phenylimidazo[1,2-b]py...)
Show SMILES COc1cc(Br)nn2c(c(nc12)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1
Show InChI InChI=1S/C23H21BrN4O/c1-29-18-14-19(24)27-28-21(16-6-3-2-4-7-16)20(26-22(18)28)15-8-10-17(11-9-15)23(25)12-5-13-23/h2-4,6-11,14H,5,12-13,25H2,1H3
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n/an/a 9.70n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312526
PNG
(US9604989, Example 14)
Show SMILES COc1cc(-c2cccnc2)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C28H25N5O/c1-34-24-17-23(21-9-5-16-30-18-21)27-31-25(26(33(27)32-24)20-7-3-2-4-8-20)19-10-12-22(13-11-19)28(29)14-6-15-28/h2-5,7-13,16-18H,6,14-15,29H2,1H3
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n/an/a 9.80n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312591
PNG
(1-[4-(8-Butoxy-6-ethoxy-3-phenylimidazo[1,2-b]pyri...)
Show SMILES CCCCOc1cc(OCC)nn2c(c(nc12)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1
Show InChI InChI=1S/C28H32N4O2/c1-3-5-18-34-23-19-24(33-4-2)31-32-26(21-10-7-6-8-11-21)25(30-27(23)32)20-12-14-22(15-13-20)28(29)16-9-17-28/h6-8,10-15,19H,3-5,9,16-18,29H2,1-2H3
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n/an/a 10n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312539
PNG
(US9604989, Example 26)
Show SMILES CNC(=O)c1cc(OC)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C25H25N5O2/c1-27-24(31)19-15-20(32-2)23-28-21(22(30(23)29-19)17-7-4-3-5-8-17)16-9-11-18(12-10-16)25(26)13-6-14-25/h3-5,7-12,15H,6,13-14,26H2,1-2H3,(H,27,31)
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312590
PNG
(US9604989, Example 76)
Show SMILES CCOc1cc(OCC)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C26H28N4O2/c1-3-31-21-17-22(32-4-2)29-30-24(19-9-6-5-7-10-19)23(28-25(21)30)18-11-13-20(14-12-18)26(27)15-8-16-26/h5-7,9-14,17H,3-4,8,15-16,27H2,1-2H3
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n/an/a 11n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312585
PNG
(US9604989, Example 71)
Show SMILES NC1(CCC1)c1ccc(cc1)-c1nc2c(cc(nn2c1-c1ccccc1)C(=O)NCCO)-c1cc[nH]n1
Show InChI InChI=1S/C28H27N7O2/c29-28(12-4-13-28)20-9-7-18(8-10-20)24-25(19-5-2-1-3-6-19)35-26(32-24)21(22-11-14-31-33-22)17-23(34-35)27(37)30-15-16-36/h1-3,5-11,14,17,36H,4,12-13,15-16,29H2,(H,30,37)(H,31,33)
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312578
PNG
(US9604989, Example 64)
Show SMILES CNC(=O)c1cc(OCC2CC2)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C28H29N5O2/c1-30-27(34)22-16-23(35-17-18-8-9-18)26-31-24(25(33(26)32-22)20-6-3-2-4-7-20)19-10-12-21(13-11-19)28(29)14-5-15-28/h2-4,6-7,10-13,16,18H,5,8-9,14-15,17,29H2,1H3,(H,30,34)
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n/an/a 12n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312568
PNG
(1-{4-[7,8-Dimethyl-6-(methylsulfanyl)-3-phenylimid...)
Show SMILES CSc1nn2c(c(nc2c(C)c1C)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1
Show InChI InChI=1S/C25H26N4S/c1-16-17(2)24(30-3)28-29-22(19-8-5-4-6-9-19)21(27-23(16)29)18-10-12-20(13-11-18)25(26)14-7-15-25/h4-6,8-13H,7,14-15,26H2,1-3H3
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n/an/a 12n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312548
PNG
(US9604989, Example 34)
Show SMILES NC(=O)c1cc(C(N)=O)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C24H22N6O2/c25-21(31)17-13-18(22(26)32)29-30-20(15-5-2-1-3-6-15)19(28-23(17)30)14-7-9-16(10-8-14)24(27)11-4-12-24/h1-3,5-10,13H,4,11-12,27H2,(H2,25,31)(H2,26,32)
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n/an/a 14n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312531
PNG
(US9604989, Example 19)
Show SMILES NC1(CCC1)c1ccc(cc1)-c1nc2c(cc(Cl)nn2c1-c1ccccc1)-c1cc[nH]n1
Show InChI InChI=1S/C25H21ClN6/c26-21-15-19(20-11-14-28-30-20)24-29-22(23(32(24)31-21)17-5-2-1-3-6-17)16-7-9-18(10-8-16)25(27)12-4-13-25/h1-3,5-11,14-15H,4,12-13,27H2,(H,28,30)
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312566
PNG
(2-[4-(1-Aminocyclobutyl)phenyl]-7,8-dimethyl-3-phe...)
Show SMILES Cc1c(C)c2nc(c(-c3ccccc3)n2nc1C(N)=O)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C25H25N5O/c1-15-16(2)24-28-21(17-9-11-19(12-10-17)25(27)13-6-14-25)22(18-7-4-3-5-8-18)30(24)29-20(15)23(26)31/h3-5,7-12H,6,13-14,27H2,1-2H3,(H2,26,31)
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n/an/a 15n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312540
PNG
(US9604989, Example 27)
Show SMILES NC1(CCC1)c1ccc(cc1)-c1nc2c(ccnn2c1-c1ccccc1)-c1cc[nH]n1
Show InChI InChI=1S/C25H22N6/c26-25(13-4-14-25)19-9-7-17(8-10-19)22-23(18-5-2-1-3-6-18)31-24(29-22)20(11-16-28-31)21-12-15-27-30-21/h1-3,5-12,15-16H,4,13-14,26H2,(H,27,30)
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n/an/a 15n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312576
PNG
(US9604989, Example 62)
Show SMILES CNC(=O)c1cc(-c2ncc[nH]2)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C27H25N7O/c1-29-26(35)21-16-20(24-30-14-15-31-24)25-32-22(23(34(25)33-21)18-6-3-2-4-7-18)17-8-10-19(11-9-17)27(28)12-5-13-27/h2-4,6-11,14-16H,5,12-13,28H2,1H3,(H,29,35)(H,30,31)
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n/an/a 16n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312570
PNG
(Methyl 2-[4-(1-aminocyclobutyl)phenyl]-3-phenyl-8-...)
Show SMILES COC(=O)c1cc(-c2cc[nH]n2)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C27H24N6O2/c1-35-26(34)22-16-20(21-12-15-29-31-21)25-30-23(24(33(25)32-22)18-6-3-2-4-7-18)17-8-10-19(11-9-17)27(28)13-5-14-27/h2-4,6-12,15-16H,5,13-14,28H2,1H3,(H,29,31)
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n/an/a 16n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312550
PNG
(US9604989, Example 36)
Show SMILES CSc1ccc2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C23H22N4S/c1-28-20-13-12-19-25-21(22(27(19)26-20)17-6-3-2-4-7-17)16-8-10-18(11-9-16)23(24)14-5-15-23/h2-4,6-13H,5,14-15,24H2,1H3
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n/an/a 17n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312534
PNG
(US9604989, Example 22)
Show SMILES CCOc1cc(nn2c(c(nc12)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1)C(=O)NC
Show InChI InChI=1S/C26H27N5O2/c1-3-33-21-16-20(25(32)28-2)30-31-23(18-8-5-4-6-9-18)22(29-24(21)31)17-10-12-19(13-11-17)26(27)14-7-15-26/h4-6,8-13,16H,3,7,14-15,27H2,1-2H3,(H,28,32)
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n/an/a 18n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312521
PNG
(1-[4-(6,8-Dimethyloxy-3-phenylimidazo[1,2-b]pyrida...)
Show SMILES COc1cc(OC)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C24H24N4O2/c1-29-19-15-20(30-2)27-28-22(17-7-4-3-5-8-17)21(26-23(19)28)16-9-11-18(12-10-16)24(25)13-6-14-24/h3-5,7-12,15H,6,13-14,25H2,1-2H3
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n/an/a 18n/an/an/an/an/an/a



BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312517
PNG
(2-[4-(1-Aminocyclobutyl)phenyl]-3-phenylimidazo[1,...)
Show SMILES NC(=O)c1ccc2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C23H21N5O/c24-22(29)18-11-12-19-26-20(21(28(19)27-18)16-5-2-1-3-6-16)15-7-9-17(10-8-15)23(25)13-4-14-23/h1-3,5-12H,4,13-14,25H2,(H2,24,29)
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312585
PNG
(US9604989, Example 71)
Show SMILES NC1(CCC1)c1ccc(cc1)-c1nc2c(cc(nn2c1-c1ccccc1)C(=O)NCCO)-c1cc[nH]n1
Show InChI InChI=1S/C28H27N7O2/c29-28(12-4-13-28)20-9-7-18(8-10-20)24-25(19-5-2-1-3-6-19)35-26(32-24)21(22-11-14-31-33-22)17-23(34-35)27(37)30-15-16-36/h1-3,5-11,14,17,36H,4,12-13,15-16,29H2,(H,30,37)(H,31,33)
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312524
PNG
(US9604989, Example 12)
Show SMILES COC(=O)c1cc(OC)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C25H24N4O3/c1-31-20-15-19(24(30)32-2)28-29-22(17-7-4-3-5-8-17)21(27-23(20)29)16-9-11-18(12-10-16)25(26)13-6-14-25/h3-5,7-12,15H,6,13-14,26H2,1-2H3
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312589
PNG
(US9604989, Example 75)
Show SMILES COc1cc(-c2ccncc2)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C28H25N5O/c1-34-24-18-23(19-12-16-30-17-13-19)27-31-25(26(33(27)32-24)21-6-3-2-4-7-21)20-8-10-22(11-9-20)28(29)14-5-15-28/h2-4,6-13,16-18H,5,14-15,29H2,1H3
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312582
PNG
(2-[4-(1-Aminocyclobutyl)phenyl]-N-methyl-3-phenyli...)
Show SMILES CNC(=O)c1ccc2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C24H23N5O/c1-26-23(30)19-12-13-20-27-21(22(29(20)28-19)17-6-3-2-4-7-17)16-8-10-18(11-9-16)24(25)14-5-15-24/h2-4,6-13H,5,14-15,25H2,1H3,(H,26,30)
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312590
PNG
(US9604989, Example 76)
Show SMILES CCOc1cc(OCC)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C26H28N4O2/c1-3-31-21-17-22(32-4-2)29-30-24(19-9-6-5-7-10-19)23(28-25(21)30)18-11-13-20(14-12-18)26(27)15-8-16-26/h5-7,9-14,17H,3-4,8,15-16,27H2,1-2H3
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312574
PNG
(US9604989, Example 60)
Show SMILES NC(=O)c1cc(-c2cc[nH]n2)c2nc(c(-c3ccccc3)n2n1)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C26H23N7O/c27-24(34)21-15-19(20-11-14-29-31-20)25-30-22(23(33(25)32-21)17-5-2-1-3-6-17)16-7-9-18(10-8-16)26(28)12-4-13-26/h1-3,5-11,14-15H,4,12-13,28H2,(H2,27,34)(H,29,31)
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312571
PNG
(US9604989, Example 57)
Show SMILES CCOc1cc(nn2c(c(nc12)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1)C(=O)OC
Show InChI InChI=1S/C26H26N4O3/c1-3-33-21-16-20(25(31)32-2)29-30-23(18-8-5-4-6-9-18)22(28-24(21)30)17-10-12-19(13-11-17)26(27)14-7-15-26/h4-6,8-13,16H,3,7,14-15,27H2,1-2H3
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (human))
BDBM312566
PNG
(2-[4-(1-Aminocyclobutyl)phenyl]-7,8-dimethyl-3-phe...)
Show SMILES Cc1c(C)c2nc(c(-c3ccccc3)n2nc1C(N)=O)-c1ccc(cc1)C1(N)CCC1
Show InChI InChI=1S/C25H25N5O/c1-15-16(2)24-28-21(17-9-11-19(12-10-17)25(27)13-6-14-25)22(18-7-4-3-5-8-18)30(24)29-20(15)23(26)31/h3-5,7-12H,6,13-14,27H2,1-2H3,(H2,26,31)
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312564
PNG
(1-[4-(6-Chloro-7,8-dimethyl-3-phenylimidazo[1,2-b]...)
Show SMILES Cc1c(Cl)nn2c(c(nc2c1C)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1
Show InChI InChI=1S/C24H23ClN4/c1-15-16(2)23-27-20(17-9-11-19(12-10-17)24(26)13-6-14-24)21(29(23)28-22(15)25)18-7-4-3-5-8-18/h3-5,7-12H,6,13-14,26H2,1-2H3
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase AKT2


(Homo sapiens (human))
BDBM312571
PNG
(US9604989, Example 57)
Show SMILES CCOc1cc(nn2c(c(nc12)-c1ccc(cc1)C1(N)CCC1)-c1ccccc1)C(=O)OC
Show InChI InChI=1S/C26H26N4O3/c1-3-33-21-16-20(25(31)32-2)29-30-23(18-8-5-4-6-9-18)22(28-24(21)30)17-10-12-19(13-11-17)26(27)14-7-15-26/h4-6,8-13,16H,3,7,14-15,27H2,1-2H3
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BAYER INTELLECTUAL PROPERTY GMBH; BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
His-tagged human recombinant kinase full-length Akt2 expressed in insect cells and activated by PDK1 was purchased form Invitrogen (part number PV 39...


US Patent US9604989 (2017)

More data for this
Ligand-Target Pair
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