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Found 43 hits from BIOMARIN PHARMACEUTICAL INC.   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histone deacetylase 3


(Homo sapiens (Human))
BDBM414898
PNG
(US10428028, Coding A14)
Show SMILES Nc1ccccc1NC(=O)c1ccc2nn(Cc3cncc(F)c3)cc2c1
Show InChI InChI=1S/C20H16FN5O/c21-16-7-13(9-23-10-16)11-26-12-15-8-14(5-6-18(15)25-26)20(27)24-19-4-2-1-3-17(19)22/h1-10,12H,11,22H2,(H,24,27)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10428028 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM414898
PNG
(US10428028, Coding A14)
Show SMILES Nc1ccccc1NC(=O)c1ccc2nn(Cc3cncc(F)c3)cc2c1
Show InChI InChI=1S/C20H16FN5O/c21-16-7-13(9-23-10-16)11-26-12-15-8-14(5-6-18(15)25-26)20(27)24-19-4-2-1-3-17(19)22/h1-10,12H,11,22H2,(H,24,27)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10428028 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM414885
PNG
(US10428028, Coding A1)
Show SMILES Nc1ccccc1NC(=O)c1ccc2n(Cc3cccnc3)ncc2c1
Show InChI InChI=1S/C20H17N5O/c21-17-5-1-2-6-18(17)24-20(26)15-7-8-19-16(10-15)12-23-25(19)13-14-4-3-9-22-11-14/h1-12H,13,21H2,(H,24,26)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10428028 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM414886
PNG
(US10428028, Coding A2)
Show SMILES Nc1ccccc1NC(=O)c1ccc2n(Cc3ccccc3)ncc2c1
Show InChI InChI=1S/C21H18N4O/c22-18-8-4-5-9-19(18)24-21(26)16-10-11-20-17(12-16)13-23-25(20)14-15-6-2-1-3-7-15/h1-13H,14,22H2,(H,24,26)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10428028 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM414886
PNG
(US10428028, Coding A2)
Show SMILES Nc1ccccc1NC(=O)c1ccc2n(Cc3ccccc3)ncc2c1
Show InChI InChI=1S/C21H18N4O/c22-18-8-4-5-9-19(18)24-21(26)16-10-11-20-17(12-16)13-23-25(20)14-15-6-2-1-3-7-15/h1-13H,14,22H2,(H,24,26)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10428028 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM414886
PNG
(US10428028, Coding A2)
Show SMILES Nc1ccccc1NC(=O)c1ccc2n(Cc3ccccc3)ncc2c1
Show InChI InChI=1S/C21H18N4O/c22-18-8-4-5-9-19(18)24-21(26)16-10-11-20-17(12-16)13-23-25(20)14-15-6-2-1-3-7-15/h1-13H,14,22H2,(H,24,26)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10428028 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM414887
PNG
(US10428028, Coding A3)
Show SMILES Cn1cc(Cn2ncc3cc(ccc23)C(=O)Nc2ccccc2N)cn1
Show InChI InChI=1S/C19H18N6O/c1-24-11-13(9-21-24)12-25-18-7-6-14(8-15(18)10-22-25)19(26)23-17-5-3-2-4-16(17)20/h2-11H,12,20H2,1H3,(H,23,26)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10428028 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM414887
PNG
(US10428028, Coding A3)
Show SMILES Cn1cc(Cn2ncc3cc(ccc23)C(=O)Nc2ccccc2N)cn1
Show InChI InChI=1S/C19H18N6O/c1-24-11-13(9-21-24)12-25-18-7-6-14(8-15(18)10-22-25)19(26)23-17-5-3-2-4-16(17)20/h2-11H,12,20H2,1H3,(H,23,26)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10428028 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM414887
PNG
(US10428028, Coding A3)
Show SMILES Cn1cc(Cn2ncc3cc(ccc23)C(=O)Nc2ccccc2N)cn1
Show InChI InChI=1S/C19H18N6O/c1-24-11-13(9-21-24)12-25-18-7-6-14(8-15(18)10-22-25)19(26)23-17-5-3-2-4-16(17)20/h2-11H,12,20H2,1H3,(H,23,26)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10428028 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM414888
PNG
(US10428028, Coding A4)
Show SMILES Nc1ccccc1NC(=O)c1ccc2n(Cc3cncc(F)c3)ncc2c1
Show InChI InChI=1S/C20H16FN5O/c21-16-7-13(9-23-11-16)12-26-19-6-5-14(8-15(19)10-24-26)20(27)25-18-4-2-1-3-17(18)22/h1-11H,12,22H2,(H,25,27)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10428028 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM414888
PNG
(US10428028, Coding A4)
Show SMILES Nc1ccccc1NC(=O)c1ccc2n(Cc3cncc(F)c3)ncc2c1
Show InChI InChI=1S/C20H16FN5O/c21-16-7-13(9-23-11-16)12-26-19-6-5-14(8-15(19)10-24-26)20(27)25-18-4-2-1-3-17(18)22/h1-11H,12,22H2,(H,25,27)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10428028 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM414889
PNG
(US10428028, Coding A5)
Show SMILES Cc1ccc(Cn2ncc3cc(ccc23)C(=O)Nc2ccccc2N)c(C)n1
Show InChI InChI=1S/C22H21N5O/c1-14-7-8-17(15(2)25-14)13-27-21-10-9-16(11-18(21)12-24-27)22(28)26-20-6-4-3-5-19(20)23/h3-12H,13,23H2,1-2H3,(H,26,28)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10428028 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM414889
PNG
(US10428028, Coding A5)
Show SMILES Cc1ccc(Cn2ncc3cc(ccc23)C(=O)Nc2ccccc2N)c(C)n1
Show InChI InChI=1S/C22H21N5O/c1-14-7-8-17(15(2)25-14)13-27-21-10-9-16(11-18(21)12-24-27)22(28)26-20-6-4-3-5-19(20)23/h3-12H,13,23H2,1-2H3,(H,26,28)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10428028 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM414889
PNG
(US10428028, Coding A5)
Show SMILES Cc1ccc(Cn2ncc3cc(ccc23)C(=O)Nc2ccccc2N)c(C)n1
Show InChI InChI=1S/C22H21N5O/c1-14-7-8-17(15(2)25-14)13-27-21-10-9-16(11-18(21)12-24-27)22(28)26-20-6-4-3-5-19(20)23/h3-12H,13,23H2,1-2H3,(H,26,28)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10428028 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM414890
PNG
(US10428028, Coding A6)
Show SMILES Nc1cc(F)ccc1NC(=O)c1ccc2n(Cc3cccnc3)ncc2c1
Show InChI InChI=1S/C20H16FN5O/c21-16-4-5-18(17(22)9-16)25-20(27)14-3-6-19-15(8-14)11-24-26(19)12-13-2-1-7-23-10-13/h1-11H,12,22H2,(H,25,27)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10428028 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM414890
PNG
(US10428028, Coding A6)
Show SMILES Nc1cc(F)ccc1NC(=O)c1ccc2n(Cc3cccnc3)ncc2c1
Show InChI InChI=1S/C20H16FN5O/c21-16-4-5-18(17(22)9-16)25-20(27)14-3-6-19-15(8-14)11-24-26(19)12-13-2-1-7-23-10-13/h1-11H,12,22H2,(H,25,27)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10428028 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM414890
PNG
(US10428028, Coding A6)
Show SMILES Nc1cc(F)ccc1NC(=O)c1ccc2n(Cc3cccnc3)ncc2c1
Show InChI InChI=1S/C20H16FN5O/c21-16-4-5-18(17(22)9-16)25-20(27)14-3-6-19-15(8-14)11-24-26(19)12-13-2-1-7-23-10-13/h1-11H,12,22H2,(H,25,27)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10428028 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM414891
PNG
(US10428028, Coding A7)
Show SMILES Nc1cc(F)ccc1NC(=O)c1ccc2n(Cc3cncc(F)c3)ncc2c1
Show InChI InChI=1S/C20H15F2N5O/c21-15-2-3-18(17(23)7-15)26-20(28)13-1-4-19-14(6-13)9-25-27(19)11-12-5-16(22)10-24-8-12/h1-10H,11,23H2,(H,26,28)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10428028 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM414891
PNG
(US10428028, Coding A7)
Show SMILES Nc1cc(F)ccc1NC(=O)c1ccc2n(Cc3cncc(F)c3)ncc2c1
Show InChI InChI=1S/C20H15F2N5O/c21-15-2-3-18(17(23)7-15)26-20(28)13-1-4-19-14(6-13)9-25-27(19)11-12-5-16(22)10-24-8-12/h1-10H,11,23H2,(H,26,28)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10428028 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM414891
PNG
(US10428028, Coding A7)
Show SMILES Nc1cc(F)ccc1NC(=O)c1ccc2n(Cc3cncc(F)c3)ncc2c1
Show InChI InChI=1S/C20H15F2N5O/c21-15-2-3-18(17(23)7-15)26-20(28)13-1-4-19-14(6-13)9-25-27(19)11-12-5-16(22)10-24-8-12/h1-10H,11,23H2,(H,26,28)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10428028 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM414892
PNG
(US10428028, Coding A8)
Show SMILES Cc1ccc(Cn2ncc3cc(ccc23)C(=O)Nc2ccc(F)cc2N)c(C)n1
Show InChI InChI=1S/C22H20FN5O/c1-13-3-4-16(14(2)26-13)12-28-21-8-5-15(9-17(21)11-25-28)22(29)27-20-7-6-18(23)10-19(20)24/h3-11H,12,24H2,1-2H3,(H,27,29)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10428028 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM414899
PNG
(US10428028, Coding A15)
Show SMILES Cc1ccc(Cn2cc3cc(ccc3n2)C(=O)Nc2ccccc2N)c(C)n1
Show InChI InChI=1S/C22H21N5O/c1-14-7-8-17(15(2)24-14)12-27-13-18-11-16(9-10-20(18)26-27)22(28)25-21-6-4-3-5-19(21)23/h3-11,13H,12,23H2,1-2H3,(H,25,28)
PDB

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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10428028 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM414892
PNG
(US10428028, Coding A8)
Show SMILES Cc1ccc(Cn2ncc3cc(ccc23)C(=O)Nc2ccc(F)cc2N)c(C)n1
Show InChI InChI=1S/C22H20FN5O/c1-13-3-4-16(14(2)26-13)12-28-21-8-5-15(9-17(21)11-25-28)22(29)27-20-7-6-18(23)10-19(20)24/h3-11H,12,24H2,1-2H3,(H,27,29)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10428028 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM414893
PNG
(US10428028, Coding A9)
Show SMILES Nc1ccccc1NC(=O)c1ccc2n(Cc3ccc(F)c(F)c3)ncc2c1
Show InChI InChI=1S/C21H16F2N4O/c22-16-7-5-13(9-17(16)23)12-27-20-8-6-14(10-15(20)11-25-27)21(28)26-19-4-2-1-3-18(19)24/h1-11H,12,24H2,(H,26,28)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10428028 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM414893
PNG
(US10428028, Coding A9)
Show SMILES Nc1ccccc1NC(=O)c1ccc2n(Cc3ccc(F)c(F)c3)ncc2c1
Show InChI InChI=1S/C21H16F2N4O/c22-16-7-5-13(9-17(16)23)12-27-20-8-6-14(10-15(20)11-25-27)21(28)26-19-4-2-1-3-18(19)24/h1-11H,12,24H2,(H,26,28)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10428028 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM414893
PNG
(US10428028, Coding A9)
Show SMILES Nc1ccccc1NC(=O)c1ccc2n(Cc3ccc(F)c(F)c3)ncc2c1
Show InChI InChI=1S/C21H16F2N4O/c22-16-7-5-13(9-17(16)23)12-27-20-8-6-14(10-15(20)11-25-27)21(28)26-19-4-2-1-3-18(19)24/h1-11H,12,24H2,(H,26,28)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10428028 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM414894
PNG
(US10428028, Coding A10)
Show SMILES Nc1cc(F)ccc1NC(=O)c1ccc2n(Cc3ccc(F)c(F)c3)ncc2c1
Show InChI InChI=1S/C21H15F3N4O/c22-15-3-5-19(18(25)9-15)27-21(29)13-2-6-20-14(8-13)10-26-28(20)11-12-1-4-16(23)17(24)7-12/h1-10H,11,25H2,(H,27,29)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10428028 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM414894
PNG
(US10428028, Coding A10)
Show SMILES Nc1cc(F)ccc1NC(=O)c1ccc2n(Cc3ccc(F)c(F)c3)ncc2c1
Show InChI InChI=1S/C21H15F3N4O/c22-15-3-5-19(18(25)9-15)27-21(29)13-2-6-20-14(8-13)10-26-28(20)11-12-1-4-16(23)17(24)7-12/h1-10H,11,25H2,(H,27,29)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10428028 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM414894
PNG
(US10428028, Coding A10)
Show SMILES Nc1cc(F)ccc1NC(=O)c1ccc2n(Cc3ccc(F)c(F)c3)ncc2c1
Show InChI InChI=1S/C21H15F3N4O/c22-15-3-5-19(18(25)9-15)27-21(29)13-2-6-20-14(8-13)10-26-28(20)11-12-1-4-16(23)17(24)7-12/h1-10H,11,25H2,(H,27,29)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10428028 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM414895
PNG
(US10428028, Coding A11)
Show SMILES Nc1ccccc1NC(=O)c1ccc2n(CC3CC3)ncc2c1
Show InChI InChI=1S/C18H18N4O/c19-15-3-1-2-4-16(15)21-18(23)13-7-8-17-14(9-13)10-20-22(17)11-12-5-6-12/h1-4,7-10,12H,5-6,11,19H2,(H,21,23)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10428028 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM414895
PNG
(US10428028, Coding A11)
Show SMILES Nc1ccccc1NC(=O)c1ccc2n(CC3CC3)ncc2c1
Show InChI InChI=1S/C18H18N4O/c19-15-3-1-2-4-16(15)21-18(23)13-7-8-17-14(9-13)10-20-22(17)11-12-5-6-12/h1-4,7-10,12H,5-6,11,19H2,(H,21,23)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10428028 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM414895
PNG
(US10428028, Coding A11)
Show SMILES Nc1ccccc1NC(=O)c1ccc2n(CC3CC3)ncc2c1
Show InChI InChI=1S/C18H18N4O/c19-15-3-1-2-4-16(15)21-18(23)13-7-8-17-14(9-13)10-20-22(17)11-12-5-6-12/h1-4,7-10,12H,5-6,11,19H2,(H,21,23)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10428028 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM414885
PNG
(US10428028, Coding A1)
Show SMILES Nc1ccccc1NC(=O)c1ccc2n(Cc3cccnc3)ncc2c1
Show InChI InChI=1S/C20H17N5O/c21-17-5-1-2-6-18(17)24-20(26)15-7-8-19-16(10-15)12-23-25(19)13-14-4-3-9-22-11-14/h1-12H,13,21H2,(H,24,26)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10428028 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM414899
PNG
(US10428028, Coding A15)
Show SMILES Cc1ccc(Cn2cc3cc(ccc3n2)C(=O)Nc2ccccc2N)c(C)n1
Show InChI InChI=1S/C22H21N5O/c1-14-7-8-17(15(2)24-14)12-27-13-18-11-16(9-10-20(18)26-27)22(28)25-21-6-4-3-5-19(21)23/h3-11,13H,12,23H2,1-2H3,(H,25,28)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10428028 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM414896
PNG
(US10428028, Coding A12)
Show SMILES Nc1cc(F)ccc1NC(=O)c1ccc2n(CC3CC3)ncc2c1
Show InChI InChI=1S/C18H17FN4O/c19-14-4-5-16(15(20)8-14)22-18(24)12-3-6-17-13(7-12)9-21-23(17)10-11-1-2-11/h3-9,11H,1-2,10,20H2,(H,22,24)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10428028 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM414897
PNG
(US10428028, Coding A13)
Show SMILES Nc1ccccc1NC(=O)c1ccc2nn(Cc3cccnc3)cc2c1
Show InChI InChI=1S/C20H17N5O/c21-17-5-1-2-6-19(17)23-20(26)15-7-8-18-16(10-15)13-25(24-18)12-14-4-3-9-22-11-14/h1-11,13H,12,21H2,(H,23,26)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10428028 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM414897
PNG
(US10428028, Coding A13)
Show SMILES Nc1ccccc1NC(=O)c1ccc2nn(Cc3cccnc3)cc2c1
Show InChI InChI=1S/C20H17N5O/c21-17-5-1-2-6-19(17)23-20(26)15-7-8-18-16(10-15)13-25(24-18)12-14-4-3-9-22-11-14/h1-11,13H,12,21H2,(H,23,26)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10428028 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM414897
PNG
(US10428028, Coding A13)
Show SMILES Nc1ccccc1NC(=O)c1ccc2nn(Cc3cccnc3)cc2c1
Show InChI InChI=1S/C20H17N5O/c21-17-5-1-2-6-19(17)23-20(26)15-7-8-18-16(10-15)13-25(24-18)12-14-4-3-9-22-11-14/h1-11,13H,12,21H2,(H,23,26)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10428028 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM414885
PNG
(US10428028, Coding A1)
Show SMILES Nc1ccccc1NC(=O)c1ccc2n(Cc3cccnc3)ncc2c1
Show InChI InChI=1S/C20H17N5O/c21-17-5-1-2-6-18(17)24-20(26)15-7-8-19-16(10-15)12-23-25(19)13-14-4-3-9-22-11-14/h1-12H,13,21H2,(H,24,26)
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n/an/a<1.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10428028 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM414896
PNG
(US10428028, Coding A12)
Show SMILES Nc1cc(F)ccc1NC(=O)c1ccc2n(CC3CC3)ncc2c1
Show InChI InChI=1S/C18H17FN4O/c19-14-4-5-16(15(20)8-14)22-18(24)12-3-6-17-13(7-12)9-21-23(17)10-11-1-2-11/h3-9,11H,1-2,10,20H2,(H,22,24)
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n/an/a 3.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10428028 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM414892
PNG
(US10428028, Coding A8)
Show SMILES Cc1ccc(Cn2ncc3cc(ccc23)C(=O)Nc2ccc(F)cc2N)c(C)n1
Show InChI InChI=1S/C22H20FN5O/c1-13-3-4-16(14(2)26-13)12-28-21-8-5-15(9-17(21)11-25-28)22(29)27-20-7-6-18(23)10-19(20)24/h3-11H,12,24H2,1-2H3,(H,27,29)
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n/an/a 3.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10428028 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM414899
PNG
(US10428028, Coding A15)
Show SMILES Cc1ccc(Cn2cc3cc(ccc3n2)C(=O)Nc2ccccc2N)c(C)n1
Show InChI InChI=1S/C22H21N5O/c1-14-7-8-17(15(2)24-14)12-27-13-18-11-16(9-10-20(18)26-27)22(28)25-21-6-4-3-5-19(21)23/h3-11,13H,12,23H2,1-2H3,(H,25,28)
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n/an/a 3.00E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10428028 (2019)

More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM414896
PNG
(US10428028, Coding A12)
Show SMILES Nc1cc(F)ccc1NC(=O)c1ccc2n(CC3CC3)ncc2c1
Show InChI InChI=1S/C18H17FN4O/c19-14-4-5-16(15(20)8-14)22-18(24)12-3-6-17-13(7-12)9-21-23(17)10-11-1-2-11/h3-9,11H,1-2,10,20H2,(H,22,24)
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n/an/a 7.50E+3n/an/an/an/an/an/a



BIOMARIN PHARMACEUTICAL INC.

US Patent


Assay Description
The HDAC activity inhibition assay was performed as follows to determine the ability of a test compound to inhibit HDAC enzymatic activity. Serial di...


US Patent US10428028 (2019)

More data for this
Ligand-Target Pair