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Compile Data Set for Download or QSAR

Found 1032 hits from BLUEPRINT MEDICINES CORPORATION   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175747
PNG
(US9688680, 292)
Show SMILES COC(=O)N1CCC(=CC1)c1cc2c(ncnn2c1)N1CC(C1)NC(=O)Cc1ccc(Cl)cc1Cl
Show InChI InChI=1S/C24H24Cl2N6O3/c1-35-24(34)30-6-4-15(5-7-30)17-8-21-23(27-14-28-32(21)11-17)31-12-19(13-31)29-22(33)9-16-2-3-18(25)10-20(16)26/h2-4,8,10-11,14,19H,5-7,9,12-13H2,1H3,(H,29,33)
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175754
PNG
(US9688680, 299)
Show SMILES CC[C@H](NC(=O)C1CN(C1)c1ncnn2cc(cc12)-c1cnn(c1)[C@@H](C)C(C)(C)O)c1ccc(Cl)cc1
Show InChI InChI=1S/C27H32ClN7O2/c1-5-23(18-6-8-22(28)9-7-18)32-26(36)21-12-33(13-21)25-24-10-19(14-35(24)31-16-29-25)20-11-30-34(15-20)17(2)27(3,4)37/h6-11,14-17,21,23,37H,5,12-13H2,1-4H3,(H,32,36)/t17-,23-/m0/s1
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175755
PNG
(US9688680, 300)
Show SMILES CC[C@H](NC(=O)C1CN(C1)c1ncnn2cc(cc12)-c1cnn(c1)[C@H](C)C(C)(C)O)c1ccc(Cl)cc1
Show InChI InChI=1S/C27H32ClN7O2/c1-5-23(18-6-8-22(28)9-7-18)32-26(36)21-12-33(13-21)25-24-10-19(14-35(24)31-16-29-25)20-11-30-34(15-20)17(2)27(3,4)37/h6-11,14-17,21,23,37H,5,12-13H2,1-4H3,(H,32,36)/t17-,23+/m1/s1
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175756
PNG
(US9688680, 301)
Show SMILES CCC(=O)N1CCC(=CC1)c1cc2c(ncnn2c1)N1CC(C1)C(=O)N[C@@H](CCO)c1ccc(Cl)cc1
Show InChI InChI=1S/C27H31ClN6O3/c1-2-25(36)32-10-7-18(8-11-32)20-13-24-26(29-17-30-34(24)16-20)33-14-21(15-33)27(37)31-23(9-12-35)19-3-5-22(28)6-4-19/h3-7,13,16-17,21,23,35H,2,8-12,14-15H2,1H3,(H,31,37)/t23-/m0/s1
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175757
PNG
(US9688680, 302)
Show SMILES CCOC(=O)N1CCC(=CC1)c1cc2c(ncnn2c1)N1CC(C1)C(=O)N[C@@H](CC)c1ccc(Cl)cc1
Show InChI InChI=1S/C27H31ClN6O3/c1-3-23(19-5-7-22(28)8-6-19)31-26(35)21-14-33(15-21)25-24-13-20(16-34(24)30-17-29-25)18-9-11-32(12-10-18)27(36)37-4-2/h5-9,13,16-17,21,23H,3-4,10-12,14-15H2,1-2H3,(H,31,35)/t23-/m0/s1
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175760
PNG
(US9688680, 305)
Show SMILES CC[C@H](NC(=O)C1CN(C1)c1ncnn2cc(cc12)-c1ccc(cc1)S(C)(=O)=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C26H26ClN5O3S/c1-3-23(18-4-8-21(27)9-5-18)30-26(33)20-13-31(14-20)25-24-12-19(15-32(24)29-16-28-25)17-6-10-22(11-7-17)36(2,34)35/h4-12,15-16,20,23H,3,13-14H2,1-2H3,(H,30,33)/t23-/m0/s1
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175763
PNG
(US9688680, 308)
Show SMILES CC1(CN(C1)c1ncnn2cc(cc12)-c1ccc(cc1)S(C)(=O)=O)C(=O)NCc1ccc(Cl)cc1F
Show InChI InChI=1S/C25H23ClFN5O3S/c1-25(24(33)28-11-17-3-6-19(26)10-21(17)27)13-31(14-25)23-22-9-18(12-32(22)30-15-29-23)16-4-7-20(8-5-16)36(2,34)35/h3-10,12,15H,11,13-14H2,1-2H3,(H,28,33)
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175764
PNG
(US9688680, 309)
Show SMILES CC[C@H](NC(=O)C1CN(C1)c1ncnn2cc(cc12)C1=CCN(CC1)S(C)(=O)=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C25H29ClN6O3S/c1-3-22(18-4-6-21(26)7-5-18)29-25(33)20-13-30(14-20)24-23-12-19(15-32(23)28-16-27-24)17-8-10-31(11-9-17)36(2,34)35/h4-8,12,15-16,20,22H,3,9-11,13-14H2,1-2H3,(H,29,33)/t22-/m0/s1
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175766
PNG
(US9688680, 311)
Show SMILES CCC(=O)N1CCC(=CC1)c1cc2c(ncnn2c1)N1CC(C)(C1)C(=O)N[C@@H](CCO)c1ccc(Cl)cc1
Show InChI InChI=1S/C28H33ClN6O3/c1-3-25(37)33-11-8-19(9-12-33)21-14-24-26(30-18-31-35(24)15-21)34-16-28(2,17-34)27(38)32-23(10-13-36)20-4-6-22(29)7-5-20/h4-8,14-15,18,23,36H,3,9-13,16-17H2,1-2H3,(H,32,38)/t23-/m0/s1
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175605
PNG
(US9688680, 154)
Show SMILES Cc1ccc(CNC(=O)C2(C)CN(C2)c2ncnn3cc(cc23)-c2ccc3C(=O)NCc3c2)cc1
Show InChI InChI=1S/C27H26N6O2/c1-17-3-5-18(6-4-17)11-29-26(35)27(2)14-32(15-27)24-23-10-21(13-33(23)31-16-30-24)19-7-8-22-20(9-19)12-28-25(22)34/h3-10,13,16H,11-12,14-15H2,1-2H3,(H,28,34)(H,29,35)
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175606
PNG
(US9688680, 155)
Show SMILES Cc1ccc(CNC(=O)C2(C)CN(C2)c2ncnn3cc(cc23)-c2ccc3NC(=O)Cc3c2)cc1
Show InChI InChI=1S/C27H26N6O2/c1-17-3-5-18(6-4-17)12-28-26(35)27(2)14-32(15-27)25-23-10-21(13-33(23)30-16-29-25)19-7-8-22-20(9-19)11-24(34)31-22/h3-10,13,16H,11-12,14-15H2,1-2H3,(H,28,35)(H,31,34)
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175608
PNG
(US9688680, 157)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2nccn3nc(cc23)-c2ccc(cc2)C2(CO)CC2)cc1
Show InChI InChI=1S/C28H29N5O2/c1-19-2-4-20(5-3-19)15-30-27(35)22-16-32(17-22)26-25-14-24(31-33(25)13-12-29-26)21-6-8-23(9-7-21)28(18-34)10-11-28/h2-9,12-14,22,34H,10-11,15-18H2,1H3,(H,30,35)
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175609
PNG
(US9688680, 158)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2ccc(cc2)C2(O)CCC2)cc1
Show InChI InChI=1S/C28H29N5O2/c1-19-3-5-20(6-4-19)14-29-27(34)23-15-32(16-23)26-25-13-22(17-33(25)31-18-30-26)21-7-9-24(10-8-21)28(35)11-2-12-28/h3-10,13,17-18,23,35H,2,11-12,14-16H2,1H3,(H,29,34)
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175613
PNG
(US9688680, 162)
Show SMILES CN(C)C(=O)c1ccc(cc1)-c1cc2c(ncnn2c1)N1CC(C1)C(=O)NCc1ccc(C)cc1
Show InChI InChI=1S/C27H28N6O2/c1-18-4-6-19(7-5-18)13-28-26(34)23-14-32(15-23)25-24-12-22(16-33(24)30-17-29-25)20-8-10-21(11-9-20)27(35)31(2)3/h4-12,16-17,23H,13-15H2,1-3H3,(H,28,34)
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175615
PNG
(US9688680, 164)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2ccc(cc2)C2(O)COC2)cc1
Show InChI InChI=1S/C27H27N5O3/c1-18-2-4-19(5-3-18)11-28-26(33)22-12-31(13-22)25-24-10-21(14-32(24)30-17-29-25)20-6-8-23(9-7-20)27(34)15-35-16-27/h2-10,14,17,22,34H,11-13,15-16H2,1H3,(H,28,33)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175619
PNG
(US9688680, 168)
Show SMILES Cc1ccc(CNC(=O)C2(C)CN(C2)c2ncnn3cc(cc23)-c2ccc(cc2)C(C)(C)O)cc1
Show InChI InChI=1S/C28H31N5O2/c1-19-5-7-20(8-6-19)14-29-26(34)28(4)16-32(17-28)25-24-13-22(15-33(24)31-18-30-25)21-9-11-23(12-10-21)27(2,3)35/h5-13,15,18,35H,14,16-17H2,1-4H3,(H,29,34)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175620
PNG
(US9688680, 169)
Show SMILES CCC(C)(O)c1ccc(cc1)-c1cc2c(ncnn2c1)N1CC(C1)C(=O)NCc1ccc(C)cc1
Show InChI InChI=1S/C28H31N5O2/c1-4-28(3,35)24-11-9-21(10-12-24)22-13-25-26(30-18-31-33(25)17-22)32-15-23(16-32)27(34)29-14-20-7-5-19(2)6-8-20/h5-13,17-18,23,35H,4,14-16H2,1-3H3,(H,29,34)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175621
PNG
(US9688680, 170)
Show SMILES C[C@H](NC(=O)C1CN(C1)c1ncnn2cc(cc12)-c1ccc(cc1)C(C)(C)O)c1ccc(C)cc1
Show InChI InChI=1S/C28H31N5O2/c1-18-5-7-20(8-6-18)19(2)31-27(34)23-14-32(15-23)26-25-13-22(16-33(25)30-17-29-26)21-9-11-24(12-10-21)28(3,4)35/h5-13,16-17,19,23,35H,14-15H2,1-4H3,(H,31,34)/t19-/m0/s1
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175624
PNG
(US9688680, 173)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)C2=CCN(CC2)C(=O)C2CC2)cc1
Show InChI InChI=1S/C27H30N6O2/c1-18-2-4-19(5-3-18)13-28-26(34)23-14-32(15-23)25-24-12-22(16-33(24)30-17-29-25)20-8-10-31(11-9-20)27(35)21-6-7-21/h2-5,8,12,16-17,21,23H,6-7,9-11,13-15H2,1H3,(H,28,34)
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175626
PNG
(US9688680, 175)
Show SMILES COCCOc1ccc(cc1)-c1cc2c(ncnn2c1)N1CC(C1)C(=O)NCc1ccc(C)cc1
Show InChI InChI=1S/C27H29N5O3/c1-19-3-5-20(6-4-19)14-28-27(33)23-15-31(16-23)26-25-13-22(17-32(25)30-18-29-26)21-7-9-24(10-8-21)35-12-11-34-2/h3-10,13,17-18,23H,11-12,14-16H2,1-2H3,(H,28,33)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175627
PNG
(US9688680, 176)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2cnn(CC3(C)COC3)c2)cc1
Show InChI InChI=1S/C26H29N7O2/c1-18-3-5-19(6-4-18)8-27-25(34)22-10-31(11-22)24-23-7-20(13-33(23)30-17-28-24)21-9-29-32(12-21)14-26(2)15-35-16-26/h3-7,9,12-13,17,22H,8,10-11,14-16H2,1-2H3,(H,27,34)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175629
PNG
(US9688680, 178)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cc2c(ncnn2c1)N1CC(C1)C(=O)Nc1ccc(cc1)C#N
Show InChI InChI=1S/C24H20N6O3S/c1-34(32,33)21-8-4-17(5-9-21)18-10-22-23(26-15-27-30(22)14-18)29-12-19(13-29)24(31)28-20-6-2-16(11-25)3-7-20/h2-10,14-15,19H,12-13H2,1H3,(H,28,31)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175630
PNG
(US9688680, 179)
Show SMILES CCC(=O)N1CCC(=CC1)c1cc2c(ncnn2c1)N1CC(C)(C1)C(=O)NCc1ccc(C)cc1
Show InChI InChI=1S/C27H32N6O2/c1-4-24(34)31-11-9-21(10-12-31)22-13-23-25(29-18-30-33(23)15-22)32-16-27(3,17-32)26(35)28-14-20-7-5-19(2)6-8-20/h5-9,13,15,18H,4,10-12,14,16-17H2,1-3H3,(H,28,35)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175637
PNG
(US9688680, 185)
Show SMILES CN(C)C(=O)N1CCC(=CC1)c1cc2c(ncnn2c1)N1CC(C1)C(=O)NCc1ccc(C)cc1
Show InChI InChI=1S/C26H31N7O2/c1-18-4-6-19(7-5-18)13-27-25(34)22-14-32(15-22)24-23-12-21(16-33(23)29-17-28-24)20-8-10-31(11-9-20)26(35)30(2)3/h4-8,12,16-17,22H,9-11,13-15H2,1-3H3,(H,27,34)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175638
PNG
(US9688680, 186)
Show SMILES COC(C)(C)Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CC(C1)C(=O)NCc1ccc(C)cc1
Show InChI InChI=1S/C26H31N7O2/c1-18-5-7-19(8-6-18)10-27-25(34)22-12-31(13-22)24-23-9-20(15-33(23)30-17-28-24)21-11-29-32(14-21)16-26(2,3)35-4/h5-9,11,14-15,17,22H,10,12-13,16H2,1-4H3,(H,27,34)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175639
PNG
(US9688680, 187)
Show SMILES C[C@H](NC(=O)C1CN(C1)c1ncnn2cc(cc12)-c1cnn(CC(C)(C)O)c1)c1ccc(C)cc1
Show InChI InChI=1S/C26H31N7O2/c1-17-5-7-19(8-6-17)18(2)30-25(34)22-11-31(12-22)24-23-9-20(14-33(23)29-16-27-24)21-10-28-32(13-21)15-26(3,4)35/h5-10,13-14,16,18,22,35H,11-12,15H2,1-4H3,(H,30,34)/t18-/m0/s1
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175640
PNG
(US9688680, 188)
Show SMILES CCOC(=O)N1CCC(=CC1)c1cc2c(ncnn2c1)N1CC(C1)C(=O)NCc1ccc(C)cc1
Show InChI InChI=1S/C26H30N6O3/c1-3-35-26(34)30-10-8-20(9-11-30)21-12-23-24(28-17-29-32(23)16-21)31-14-22(15-31)25(33)27-13-19-6-4-18(2)5-7-19/h4-8,12,16-17,22H,3,9-11,13-15H2,1-2H3,(H,27,33)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175642
PNG
(US9688680, 190)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2ccc(cc2)S(C)(=O)=O)cc1
Show InChI InChI=1S/C25H25N5O3S/c1-17-3-5-18(6-4-17)12-26-25(31)21-13-29(14-21)24-23-11-20(15-30(23)28-16-27-24)19-7-9-22(10-8-19)34(2,32)33/h3-11,15-16,21H,12-14H2,1-2H3,(H,26,31)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175645
PNG
(US9688680, 192)
Show SMILES C[C@H](NC(=O)C1CN(C1)c1ncnn2cc(cc12)-c1cnn(CC(C)(C)O)c1)c1ccc(F)cc1
Show InChI InChI=1S/C25H28FN7O2/c1-16(17-4-6-21(26)7-5-17)30-24(34)20-10-31(11-20)23-22-8-18(13-33(22)29-15-27-23)19-9-28-32(12-19)14-25(2,3)35/h4-9,12-13,15-16,20,35H,10-11,14H2,1-3H3,(H,30,34)/t16-/m0/s1
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175646
PNG
(US9688680, 193)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2cnn(CC(C)(C)O)c2)c(F)c1
Show InChI InChI=1S/C25H28FN7O2/c1-16-4-5-17(21(26)6-16)8-27-24(34)20-10-31(11-20)23-22-7-18(13-33(22)30-15-28-23)19-9-29-32(12-19)14-25(2,3)35/h4-7,9,12-13,15,20,35H,8,10-11,14H2,1-3H3,(H,27,34)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175648
PNG
(US9688680, 195)
Show SMILES CC[C@H](O)Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CC(C1)C(=O)N[C@@H](C)c1ccc(F)cc1
Show InChI InChI=1S/C25H28FN7O2/c1-3-22(34)14-32-12-19(9-28-32)18-8-23-24(27-15-29-33(23)13-18)31-10-20(11-31)25(35)30-16(2)17-4-6-21(26)7-5-17/h4-9,12-13,15-16,20,22,34H,3,10-11,14H2,1-2H3,(H,30,35)/t16-,22-/m0/s1
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175652
PNG
(US9688680, 199)
Show SMILES COC(=O)N1CCC(=CC1)c1cc2c(ncnn2c1)N1CC(C1)C(=O)N[C@@H](C)c1ccc(F)cc1
Show InChI InChI=1S/C25H27FN6O3/c1-16(17-3-5-21(26)6-4-17)29-24(33)20-12-31(13-20)23-22-11-19(14-32(22)28-15-27-23)18-7-9-30(10-8-18)25(34)35-2/h3-7,11,14-16,20H,8-10,12-13H2,1-2H3,(H,29,33)/t16-/m0/s1
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175655
PNG
(US9688680, 202)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CC(C)(C1)C(=O)N[C@@H](CCO)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H26ClN7O2/c1-24(23(34)29-20(7-8-33)16-3-5-19(25)6-4-16)13-31(14-24)22-21-9-17(12-32(21)28-15-26-22)18-10-27-30(2)11-18/h3-6,9-12,15,20,33H,7-8,13-14H2,1-2H3,(H,29,34)/t20-/m0/s1
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175657
PNG
(US9688680, 204)
Show SMILES CC(C)(O)Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CC(C1)C(=O)NCc1ccc(Cl)cc1
Show InChI InChI=1S/C24H26ClN7O2/c1-24(2,34)14-31-12-18(9-28-31)17-7-21-22(27-15-29-32(21)13-17)30-10-19(11-30)23(33)26-8-16-3-5-20(25)6-4-16/h3-7,9,12-13,15,19,34H,8,10-11,14H2,1-2H3,(H,26,33)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175660
PNG
(US9688680, 206)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2ccc(cc2)N2CCCC2=O)cc1
Show InChI InChI=1S/C28H28N6O2/c1-19-4-6-20(7-5-19)14-29-28(36)23-15-32(16-23)27-25-13-22(17-34(25)31-18-30-27)21-8-10-24(11-9-21)33-12-2-3-26(33)35/h4-11,13,17-18,23H,2-3,12,14-16H2,1H3,(H,29,36)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175661
PNG
(US9688680, 207)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)C2=CCN(CC2)S(C)(=O)=O)cc1
Show InChI InChI=1S/C24H28N6O3S/c1-17-3-5-18(6-4-17)12-25-24(31)21-13-28(14-21)23-22-11-20(15-30(22)27-16-26-23)19-7-9-29(10-8-19)34(2,32)33/h3-7,11,15-16,21H,8-10,12-14H2,1-2H3,(H,25,31)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175664
PNG
(US9688680, 210)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2ccc(cc2)C(C)(O)C2CC2)cc1
Show InChI InChI=1S/C29H31N5O2/c1-19-3-5-20(6-4-19)14-30-28(35)23-15-33(16-23)27-26-13-22(17-34(26)32-18-31-27)21-7-9-24(10-8-21)29(2,36)25-11-12-25/h3-10,13,17-18,23,25,36H,11-12,14-16H2,1-2H3,(H,30,35)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175667
PNG
(US9688680, 213)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2ccc(cc2)C2(O)CCOC2)cc1
Show InChI InChI=1S/C28H29N5O3/c1-19-2-4-20(5-3-19)13-29-27(34)23-14-32(15-23)26-25-12-22(16-33(25)31-18-30-26)21-6-8-24(9-7-21)28(35)10-11-36-17-28/h2-9,12,16,18,23,35H,10-11,13-15,17H2,1H3,(H,29,34)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175673
PNG
(US9688680, 218)
Show SMILES CN(C)C(=O)c1ccc(cc1)-c1cc2c(ncnn2c1)N1CC(C1)C(=O)N[C@@H](CO)c1ccccc1
Show InChI InChI=1S/C27H28N6O3/c1-31(2)27(36)20-10-8-18(9-11-20)21-12-24-25(28-17-29-33(24)15-21)32-13-22(14-32)26(35)30-23(16-34)19-6-4-3-5-7-19/h3-12,15,17,22-23,34H,13-14,16H2,1-2H3,(H,30,35)/t23-/m0/s1
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175674
PNG
(US9688680, 219)
Show SMILES CN(C)C(=O)c1ccc(cc1)-c1cc2c(ncnn2c1)N1CC(C1)C(=O)N[C@H](CO)c1ccccc1
Show InChI InChI=1S/C27H28N6O3/c1-31(2)27(36)20-10-8-18(9-11-20)21-12-24-25(28-17-29-33(24)15-21)32-13-22(14-32)26(35)30-23(16-34)19-6-4-3-5-7-19/h3-12,15,17,22-23,34H,13-14,16H2,1-2H3,(H,30,35)/t23-/m1/s1
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175675
PNG
(US9688680, 220)
Show SMILES C[C@H](NC(=O)C1CN(C1)c1ncnn2cc(cc12)-c1ccc(cc1)C1(O)CCC1)c1ccc(F)cc1
Show InChI InChI=1S/C28H28FN5O2/c1-18(19-5-9-24(29)10-6-19)32-27(35)22-14-33(15-22)26-25-13-21(16-34(25)31-17-30-26)20-3-7-23(8-4-20)28(36)11-2-12-28/h3-10,13,16-18,22,36H,2,11-12,14-15H2,1H3,(H,32,35)/t18-/m0/s1
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175677
PNG
(US9688680, 222)
Show SMILES COC1(CN(C1)c1ncnn2cc(cc12)-c1ccc(cc1)C(C)(C)O)C(=O)NCc1ccc(C)cc1
Show InChI InChI=1S/C28H31N5O3/c1-19-5-7-20(8-6-19)14-29-26(34)28(36-4)16-32(17-28)25-24-13-22(15-33(24)31-18-30-25)21-9-11-23(12-10-21)27(2,3)35/h5-13,15,18,35H,14,16-17H2,1-4H3,(H,29,34)
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175678
PNG
(US9688680, 223)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2cnn(C[C@@H]3CNCCO3)c2)cc1
Show InChI InChI=1S/C26H30N8O2/c1-18-2-4-19(5-3-18)9-28-26(35)22-12-32(13-22)25-24-8-20(15-34(24)31-17-29-25)21-10-30-33(14-21)16-23-11-27-6-7-36-23/h2-5,8,10,14-15,17,22-23,27H,6-7,9,11-13,16H2,1H3,(H,28,35)/t23-/m0/s1
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175679
PNG
(US9688680, 224)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)C2=CCN(CC2)C(=O)C(C)(C)C)cc1
Show InChI InChI=1S/C28H34N6O2/c1-19-5-7-20(8-6-19)14-29-26(35)23-15-33(16-23)25-24-13-22(17-34(24)31-18-30-25)21-9-11-32(12-10-21)27(36)28(2,3)4/h5-9,13,17-18,23H,10-12,14-16H2,1-4H3,(H,29,35)
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175684
PNG
(US9688680, 229)
Show SMILES CC(C)OC(=O)N1CCC(=CC1)c1cc2c(ncnn2c1)N1CC(C1)C(=O)NCc1ccc(C)cc1
Show InChI InChI=1S/C27H32N6O3/c1-18(2)36-27(35)31-10-8-21(9-11-31)22-12-24-25(29-17-30-33(24)16-22)32-14-23(15-32)26(34)28-13-20-6-4-19(3)5-7-20/h4-8,12,16-18,23H,9-11,13-15H2,1-3H3,(H,28,34)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175685
PNG
(US9688680, 230)
Show SMILES C[C@H](NC(=O)C1CN(C1)c1ncnn2cc(cc12)-c1cnn(CC2(C)COC2)c1)c1ccc(F)cc1
Show InChI InChI=1S/C26H28FN7O2/c1-17(18-3-5-22(27)6-4-18)31-25(35)21-9-32(10-21)24-23-7-19(12-34(23)30-16-28-24)20-8-29-33(11-20)13-26(2)14-36-15-26/h3-8,11-12,16-17,21H,9-10,13-15H2,1-2H3,(H,31,35)/t17-/m0/s1
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175687
PNG
(US9688680, 232)
Show SMILES Cc1ccc(CNC(=O)C2(C)CN(C2)c2ncnn3cc(cc23)-c2ccc(cc2)S(C)(=O)=O)cc1
Show InChI InChI=1S/C26H27N5O3S/c1-18-4-6-19(7-5-18)13-27-25(32)26(2)15-30(16-26)24-23-12-21(14-31(23)29-17-28-24)20-8-10-22(11-9-20)35(3,33)34/h4-12,14,17H,13,15-16H2,1-3H3,(H,27,32)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175690
PNG
(US9688680, 235)
Show SMILES COC(=O)N1CCC(=CC1)c1cc2c(ncnn2c1)N1CC(C1)(OC)C(=O)NCc1ccc(C)cc1
Show InChI InChI=1S/C26H30N6O4/c1-18-4-6-19(7-5-18)13-27-24(33)26(36-3)15-31(16-26)23-22-12-21(14-32(22)29-17-28-23)20-8-10-30(11-9-20)25(34)35-2/h4-8,12,14,17H,9-11,13,15-16H2,1-3H3,(H,27,33)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175693
PNG
(US9688680, 238)
Show SMILES C[C@H](NC(=O)C1CN(C1)c1ncnn2cc(cc12)-c1cnn(c1)[C@@H](C)C(C)(C)O)c1ccc(F)cc1
Show InChI InChI=1S/C26H30FN7O2/c1-16(18-5-7-22(27)8-6-18)31-25(35)21-11-32(12-21)24-23-9-19(13-34(23)30-15-28-24)20-10-29-33(14-20)17(2)26(3,4)36/h5-10,13-17,21,36H,11-12H2,1-4H3,(H,31,35)/t16-,17-/m0/s1
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175694
PNG
(US9688680, 239)
Show SMILES C[C@H](NC(=O)C1CN(C1)c1ncnn2cc(cc12)-c1cnn(c1)[C@H](C)C(C)(C)O)c1ccc(F)cc1
Show InChI InChI=1S/C26H30FN7O2/c1-16(18-5-7-22(27)8-6-18)31-25(35)21-11-32(12-21)24-23-9-19(13-34(23)30-15-28-24)20-10-29-33(14-20)17(2)26(3,4)36/h5-10,13-17,21,36H,11-12H2,1-4H3,(H,31,35)/t16-,17+/m0/s1
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
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