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Compile Data Set for Download or QSAR

Found 1806 hits from BLUEPRINT MEDICINES CORPORATION   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
High affinity nerve growth factor receptor


(Homo sapiens (Human))
BDBM158154
PNG
(US10081622, Compound 11 | US10370379, Entrectinib ...)
Show SMILES CN1CCN(CC1)c1ccc(C(=O)Nc2n[nH]c3ccc(Cc4cc(F)cc(F)c4)cc23)c(NC2CCOCC2)c1
Show InChI InChI=1S/C31H34F2N6O2/c1-38-8-10-39(11-9-38)25-3-4-26(29(19-25)34-24-6-12-41-13-7-24)31(40)35-30-27-17-20(2-5-28(27)36-37-30)14-21-15-22(32)18-23(33)16-21/h2-5,15-19,24,34H,6-14H2,1H3,(H2,35,36,37,40)
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US Patent
n/an/a 0.600n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 1 nM-1.5 nM of wild type NTRK1 enzyme (BPS Bioscience; 40280) was incubated in a total of 12.5 μL of buffer (1...


US Patent US10370379 (2019)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175646
PNG
(US9688680, 193)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2cnn(CC(C)(C)O)c2)c(F)c1
Show InChI InChI=1S/C25H28FN7O2/c1-16-4-5-17(21(26)6-16)8-27-24(34)20-10-31(11-20)23-22-7-18(13-33(22)30-15-28-23)19-9-29-32(12-19)14-25(2,3)35/h4-7,9,12-13,15,20,35H,8,10-11,14H2,1-3H3,(H,27,34)
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n/an/a<1n/an/an/an/a7.525



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175472
PNG
(US9688680, 72)
Show SMILES CC[C@H](NC(=O)C1CN(C1)c1ncnn2cc(cc12)-c1cn[nH]c1)c1ccc(Cl)cc1
Show InChI InChI=1/C22H22ClN7O/c1-2-19(14-3-5-18(23)6-4-14)28-22(31)17-10-29(11-17)21-20-7-15(16-8-25-26-9-16)12-30(20)27-13-24-21/h3-9,12-13,17,19H,2,10-11H2,1H3,(H,25,26)(H,28,31)/t19-/s2
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n/an/a<1n/an/an/an/a7.525



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175474
PNG
(US9688680, 74)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2ccc(cc2)C2CC2)cc1
Show InChI InChI=1S/C27H27N5O/c1-18-2-4-19(5-3-18)13-28-27(33)24-14-31(15-24)26-25-12-23(16-32(25)30-17-29-26)22-10-8-21(9-11-22)20-6-7-20/h2-5,8-12,16-17,20,24H,6-7,13-15H2,1H3,(H,28,33)
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n/an/a<1n/an/an/an/a7.525



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175476
PNG
(US9688680, 76)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CC(C1)C(=O)NCc1ccc(Cl)cc1F
Show InChI InChI=1S/C21H19ClFN7O/c1-28-8-15(7-26-28)14-4-19-20(25-12-27-30(19)11-14)29-9-16(10-29)21(31)24-6-13-2-3-17(22)5-18(13)23/h2-5,7-8,11-12,16H,6,9-10H2,1H3,(H,24,31)
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n/an/a<1n/an/an/an/a7.525



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175477
PNG
(US9688680, 77)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CC(C1)NC(=O)Cc1ccc(Cl)cc1F
Show InChI InChI=1S/C21H19ClFN7O/c1-28-8-15(7-25-28)14-4-19-21(24-12-26-30(19)9-14)29-10-17(11-29)27-20(31)5-13-2-3-16(22)6-18(13)23/h2-4,6-9,12,17H,5,10-11H2,1H3,(H,27,31)
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n/an/a<1n/an/an/an/a7.525



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175479
PNG
(US9688680, 79)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2cnn(c2)C2CCC2)cc1
Show InChI InChI=1S/C25H27N7O/c1-17-5-7-18(8-6-17)10-26-25(33)21-12-30(13-21)24-23-9-19(14-32(23)29-16-27-24)20-11-28-31(15-20)22-3-2-4-22/h5-9,11,14-16,21-22H,2-4,10,12-13H2,1H3,(H,26,33)
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n/an/a<1n/an/an/an/a7.525



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175480
PNG
(US9688680, 80)
Show SMILES CN(C)c1ccc(cn1)-c1cc2c(ncnn2c1)N1CC(C1)C(=O)NCc1ccc(C)cc1
Show InChI InChI=1S/C25H27N7O/c1-17-4-6-18(7-5-17)11-27-25(33)21-13-31(14-21)24-22-10-20(15-32(22)29-16-28-24)19-8-9-23(26-12-19)30(2)3/h4-10,12,15-16,21H,11,13-14H2,1-3H3,(H,27,33)
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n/an/a<1n/an/an/an/a7.525



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175485
PNG
(US9688680, 85)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2cnn(c2)C(C)(C)C)cc1
Show InChI InChI=1S/C25H29N7O/c1-17-5-7-18(8-6-17)10-26-24(33)21-12-30(13-21)23-22-9-19(14-31(22)29-16-27-23)20-11-28-32(15-20)25(2,3)4/h5-9,11,14-16,21H,10,12-13H2,1-4H3,(H,26,33)
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n/an/a<1n/an/an/an/a7.525



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175489
PNG
(US9688680, 89)
Show SMILES CC(C)n1cc(c(N)n1)-c1cc2c(ncnn2c1)N1CC(C1)C(=O)NCc1ccc(C)cc1
Show InChI InChI=1S/C24H28N8O/c1-15(2)31-13-20(22(25)29-31)18-8-21-23(27-14-28-32(21)12-18)30-10-19(11-30)24(33)26-9-17-6-4-16(3)5-7-17/h4-8,12-15,19H,9-11H2,1-3H3,(H2,25,29)(H,26,33)
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n/an/a<1n/an/an/an/a7.525



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175490
PNG
(US9688680, 90)
Show SMILES Cc1ccc(cc1)[C@H](CCN)NC(=O)C1CN(C1)c1ncnn2cc(cc12)-c1cnn(C)c1
Show InChI InChI=1/C24H28N8O/c1-16-3-5-17(6-4-16)21(7-8-25)29-24(33)20-12-31(13-20)23-22-9-18(14-32(22)28-15-26-23)19-10-27-30(2)11-19/h3-6,9-11,14-15,20-21H,7-8,12-13,25H2,1-2H3,(H,29,33)/t21-/s2
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n/an/a<1n/an/an/an/a7.525



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175492
PNG
(US9688680, 92)
Show SMILES COc1ccc(cc1F)-c1cc2c(ncnn2c1)N1CC(C1)C(=O)NCc1ccc(C)cc1
Show InChI InChI=1S/C25H24FN5O2/c1-16-3-5-17(6-4-16)11-27-25(32)20-12-30(13-20)24-22-10-19(14-31(22)29-15-28-24)18-7-8-23(33-2)21(26)9-18/h3-10,14-15,20H,11-13H2,1-2H3,(H,27,32)
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n/an/a<1n/an/an/an/a7.525



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175493
PNG
(US9688680, 93)
Show SMILES C[C@H](O)Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CC(C1)C(=O)NCc1ccc(C)cc1
Show InChI InChI=1/C24H27N7O2/c1-16-3-5-18(6-4-16)8-25-24(33)21-11-29(12-21)23-22-7-19(14-31(22)28-15-26-23)20-9-27-30(13-20)10-17(2)32/h3-7,9,13-15,17,21,32H,8,10-12H2,1-2H3,(H,25,33)/t17-/s2
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n/an/a<1n/an/an/an/a7.525



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175494
PNG
(US9688680, 94)
Show SMILES Cc1ccc(cc1)[C@H](CCO)NC(=O)C1CN(C1)c1ncnn2cc(cc12)-c1cnn(C)c1
Show InChI InChI=1/C24H27N7O2/c1-16-3-5-17(6-4-16)21(7-8-32)28-24(33)20-12-30(13-20)23-22-9-18(14-31(22)27-15-25-23)19-10-26-29(2)11-19/h3-6,9-11,14-15,20-21,32H,7-8,12-13H2,1-2H3,(H,28,33)/t21-/s2
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n/an/a<1n/an/an/an/a7.525



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175520
PNG
(US9688680, 103)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CC(C1)C(=O)N[C@@H](CO)c1ccc(Cl)cc1
Show InChI InChI=1/C22H22ClN7O2/c1-28-8-16(7-25-28)15-6-20-21(24-13-26-30(20)11-15)29-9-17(10-29)22(32)27-19(12-31)14-2-4-18(23)5-3-14/h2-8,11,13,17,19,31H,9-10,12H2,1H3,(H,27,32)/t19-/s2
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n/an/a<1n/an/an/an/a7.525



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175529
PNG
(US9688680, 105)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2ccc3C(=O)NCc3c2)cc1
Show InChI InChI=1S/C26H24N6O2/c1-16-2-4-17(5-3-16)10-27-25(33)21-12-31(13-21)24-23-9-20(14-32(23)30-15-29-24)18-6-7-22-19(8-18)11-28-26(22)34/h2-9,14-15,21H,10-13H2,1H3,(H,27,33)(H,28,34)
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n/an/a<1n/an/an/an/a7.525



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175536
PNG
(US9688680, 107)
Show SMILES CC(C)(O)c1ccc(cc1)-c1cc2c(ncnn2c1)N1CC(C1)C(=O)Nc1ccc(cc1)C#N
Show InChI InChI=1S/C26H24N6O2/c1-26(2,34)21-7-5-18(6-8-21)19-11-23-24(28-16-29-32(23)15-19)31-13-20(14-31)25(33)30-22-9-3-17(12-27)4-10-22/h3-11,15-16,20,34H,13-14H2,1-2H3,(H,30,33)
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n/an/a<1n/an/an/an/a7.525



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175550
PNG
(US9688680, 108)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2ccc(cc2)C2(N)CC2)cc1
Show InChI InChI=1S/C27H28N6O/c1-18-2-4-19(5-3-18)13-29-26(34)22-14-32(15-22)25-24-12-21(16-33(24)31-17-30-25)20-6-8-23(9-7-20)27(28)10-11-27/h2-9,12,16-17,22H,10-11,13-15,28H2,1H3,(H,29,34)
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n/an/a<1n/an/an/an/a7.525



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175555
PNG
(US9688680, 109)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2ccc(OC3CC3)cc2)cc1
Show InChI InChI=1S/C27H27N5O2/c1-18-2-4-19(5-3-18)13-28-27(33)22-14-31(15-22)26-25-12-21(16-32(25)30-17-29-26)20-6-8-23(9-7-20)34-24-10-11-24/h2-9,12,16-17,22,24H,10-11,13-15H2,1H3,(H,28,33)
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n/an/a<1n/an/an/an/a7.525



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175559
PNG
(US9688680, 111)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2ccc(cc2)C(C)(C)N)cc1
Show InChI InChI=1S/C27H30N6O/c1-18-4-6-19(7-5-18)13-29-26(34)22-14-32(15-22)25-24-12-21(16-33(24)31-17-30-25)20-8-10-23(11-9-20)27(2,3)28/h4-12,16-17,22H,13-15,28H2,1-3H3,(H,29,34)
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n/an/a<1n/an/an/an/a7.525



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175565
PNG
(US9688680, 116)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2cccc(c2)C(C)(C)O)cc1
Show InChI InChI=1S/C27H29N5O2/c1-18-7-9-19(10-8-18)13-28-26(33)22-14-31(15-22)25-24-12-21(16-32(24)30-17-29-25)20-5-4-6-23(11-20)27(2,3)34/h4-12,16-17,22,34H,13-15H2,1-3H3,(H,28,33)
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Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175566
PNG
(US9688680, 117)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2ccc(cc2)C(C)(C)O)cc1
Show InChI InChI=1S/C27H29N5O2/c1-18-4-6-19(7-5-18)13-28-26(33)22-14-31(15-22)25-24-12-21(16-32(24)30-17-29-25)20-8-10-23(11-9-20)27(2,3)34/h4-12,16-17,22,34H,13-15H2,1-3H3,(H,28,33)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175568
PNG
(US9688680, 119)
Show SMILES CC[C@H](NC(=O)C1CN(C1)c1ncnn2cc(cc12)-c1cnn(C)c1)c1ccc(cc1)C1CC1
Show InChI InChI=1/C26H29N7O/c1-3-23(19-8-6-18(7-9-19)17-4-5-17)30-26(34)22-13-32(14-22)25-24-10-20(15-33(24)29-16-27-25)21-11-28-31(2)12-21/h6-12,15-17,22-23H,3-5,13-14H2,1-2H3,(H,30,34)/t23-/s2
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BLUEPRINT MEDICINES CORPORATION

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Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175569
PNG
(US9688680, 120)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CC(C1)C(=O)NCc1ccc(Cl)cc1Cl
Show InChI InChI=1S/C21H19Cl2N7O/c1-28-8-15(7-26-28)14-4-19-20(25-12-27-30(19)11-14)29-9-16(10-29)21(31)24-6-13-2-3-17(22)5-18(13)23/h2-5,7-8,11-12,16H,6,9-10H2,1H3,(H,24,31)
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BLUEPRINT MEDICINES CORPORATION

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Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175570
PNG
(US9688680, 121)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CC(C1)NC(=O)Cc1ccc(Cl)cc1Cl
Show InChI InChI=1S/C21H19Cl2N7O/c1-28-8-15(7-25-28)14-4-19-21(24-12-26-30(19)9-14)29-10-17(11-29)27-20(31)5-13-2-3-16(22)6-18(13)23/h2-4,6-9,12,17H,5,10-11H2,1H3,(H,27,31)
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Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175571
PNG
(US9688680, 122)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2cnn(c2)C2CCNC2)cc1
Show InChI InChI=1/C25H28N8O/c1-17-2-4-18(5-3-17)9-27-25(34)21-12-31(13-21)24-23-8-19(14-33(23)30-16-28-24)20-10-29-32(15-20)22-6-7-26-11-22/h2-5,8,10,14-16,21-22,26H,6-7,9,11-13H2,1H3,(H,27,34)
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BLUEPRINT MEDICINES CORPORATION

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Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175575
PNG
(US9688680, 124)
Show SMILES COC(=O)N1CCC(=CC1)c1cc2c(ncnn2c1)N1CC(C1)C(=O)Nc1ccc(cc1)C#N
Show InChI InChI=1S/C24H23N7O3/c1-34-24(33)29-8-6-17(7-9-29)18-10-21-22(26-15-27-31(21)14-18)30-12-19(13-30)23(32)28-20-4-2-16(11-25)3-5-20/h2-6,10,14-15,19H,7-9,12-13H2,1H3,(H,28,32)
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BLUEPRINT MEDICINES CORPORATION

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Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175576
PNG
(US9688680, 125)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2ccc(cc2)C(O)CO)cc1
Show InChI InChI=1/C26H27N5O3/c1-17-2-4-18(5-3-17)11-27-26(34)22-12-30(13-22)25-23-10-21(14-31(23)29-16-28-25)19-6-8-20(9-7-19)24(33)15-32/h2-10,14,16,22,24,32-33H,11-13,15H2,1H3,(H,27,34)
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Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175577
PNG
(US9688680, 126)
Show SMILES CCC(=O)N1CCC(=CC1)c1cc2c(ncnn2c1)N1CC(C1)C(=O)NCc1ccc(C)cc1
Show InChI InChI=1S/C26H30N6O2/c1-3-24(33)30-10-8-20(9-11-30)21-12-23-25(28-17-29-32(23)16-21)31-14-22(15-31)26(34)27-13-19-6-4-18(2)5-7-19/h4-8,12,16-17,22H,3,9-11,13-15H2,1-2H3,(H,27,34)
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BLUEPRINT MEDICINES CORPORATION

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Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175578
PNG
(US9688680, 127)
Show SMILES CCC(=O)N1CCC=C(C1)c1cc2c(ncnn2c1)N1CC(C1)C(=O)NCc1ccc(C)cc1
Show InChI InChI=1S/C26H30N6O2/c1-3-24(33)30-10-4-5-20(13-30)21-11-23-25(28-17-29-32(23)16-21)31-14-22(15-31)26(34)27-12-19-8-6-18(2)7-9-19/h5-9,11,16-17,22H,3-4,10,12-15H2,1-2H3,(H,27,34)
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BLUEPRINT MEDICINES CORPORATION

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Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175581
PNG
(US9688680, 130)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2cnn(CC(C)(C)O)c2)cc1
Show InChI InChI=1S/C25H29N7O2/c1-17-4-6-18(7-5-17)9-26-24(33)21-11-30(12-21)23-22-8-19(14-32(22)29-16-27-23)20-10-28-31(13-20)15-25(2,3)34/h4-8,10,13-14,16,21,34H,9,11-12,15H2,1-3H3,(H,26,33)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175214
PNG
(US9688680, 2)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2cn[nH]c2)cc1
Show InChI InChI=1S/C21H21N7O/c1-14-2-4-15(5-3-14)7-22-21(29)18-10-27(11-18)20-19-6-16(17-8-24-25-9-17)12-28(19)26-13-23-20/h2-6,8-9,12-13,18H,7,10-11H2,1H3,(H,22,29)(H,24,25)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175217
PNG
(US9688680, 5)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CC(C1)C(=O)Nc1ccc(cc1)C#N
Show InChI InChI=1S/C21H18N8O/c1-27-9-16(8-24-27)15-6-19-20(23-13-25-29(19)12-15)28-10-17(11-28)21(30)26-18-4-2-14(7-22)3-5-18/h2-6,8-9,12-13,17H,10-11H2,1H3,(H,26,30)
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Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175215
PNG
(US9688680, 3 | US9688680, 6)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2cnn(C)c2)cc1
Show InChI InChI=1S/C22H23N7O/c1-15-3-5-16(6-4-15)8-23-22(30)19-11-28(12-19)21-20-7-17(13-29(20)26-14-24-21)18-9-25-27(2)10-18/h3-7,9-10,13-14,19H,8,11-12H2,1-2H3,(H,23,30)
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Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175225
PNG
(US9688680, 12)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)C2=CCOCC2)cc1
Show InChI InChI=1S/C23H25N5O2/c1-16-2-4-17(5-3-16)11-24-23(29)20-12-27(13-20)22-21-10-19(14-28(21)26-15-25-22)18-6-8-30-9-7-18/h2-6,10,14-15,20H,7-9,11-13H2,1H3,(H,24,29)
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Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175227
PNG
(US9688680, 14)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2cnn(C)c2)s1
Show InChI InChI=1S/C20H21N7OS/c1-13-3-4-17(29-13)7-21-20(28)16-9-26(10-16)19-18-5-14(11-27(18)24-12-22-19)15-6-23-25(2)8-15/h3-6,8,11-12,16H,7,9-10H2,1-2H3,(H,21,28)
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Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175228
PNG
(US9688680, 15)
Show SMILES Cc1csc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2cnn(C)c2)c1
Show InChI InChI=1S/C20H21N7OS/c1-13-3-17(29-11-13)6-21-20(28)16-8-26(9-16)19-18-4-14(10-27(18)24-12-22-19)15-5-23-25(2)7-15/h3-5,7,10-12,16H,6,8-9H2,1-2H3,(H,21,28)
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Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175231
PNG
(US9688680, 17)
Show SMILES Cc1nn(C)cc1-c1cc2c(ncnn2c1)N1CC(C1)C(=O)Nc1ccc(cc1)C#N
Show InChI InChI=1S/C22H20N8O/c1-14-19(12-28(2)27-14)16-7-20-21(24-13-25-30(20)11-16)29-9-17(10-29)22(31)26-18-5-3-15(8-23)4-6-18/h3-7,11-13,17H,9-10H2,1-2H3,(H,26,31)
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Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175421
PNG
(US9688680, 21)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2ccc(N)nc2)cc1
Show InChI InChI=1S/C23H23N7O/c1-15-2-4-16(5-3-15)9-26-23(31)19-11-29(12-19)22-20-8-18(13-30(20)28-14-27-22)17-6-7-21(24)25-10-17/h2-8,10,13-14,19H,9,11-12H2,1H3,(H2,24,25)(H,26,31)
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Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175422
PNG
(US9688680, 22)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2ccc(F)cc2)cc1
Show InChI InChI=1S/C24H22FN5O/c1-16-2-4-17(5-3-16)11-26-24(31)20-12-29(13-20)23-22-10-19(14-30(22)28-15-27-23)18-6-8-21(25)9-7-18/h2-10,14-15,20H,11-13H2,1H3,(H,26,31)
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Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175423
PNG
(US9688680, 23)
Show SMILES C[C@H](NC(=O)C1CN(C1)c1ncnn2cc(cc12)-c1cnn(C)c1)c1ccc(C)cc1
Show InChI InChI=1/C23H25N7O/c1-15-4-6-17(7-5-15)16(2)27-23(31)20-11-29(12-20)22-21-8-18(13-30(21)26-14-24-22)19-9-25-28(3)10-19/h4-10,13-14,16,20H,11-12H2,1-3H3,(H,27,31)/t16-/s2
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US Patent
n/an/a<1n/an/an/an/a7.525



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175424
PNG
(US9688680, 24)
Show SMILES Cc1c(cnn1C)-c1cc2c(ncnn2c1)N1CC(C1)C(=O)NCc1ccc(C)cc1
Show InChI InChI=1S/C23H25N7O/c1-15-4-6-17(7-5-15)9-24-23(31)19-11-29(12-19)22-21-8-18(13-30(21)27-14-25-22)20-10-26-28(3)16(20)2/h4-8,10,13-14,19H,9,11-12H2,1-3H3,(H,24,31)
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n/an/a<1n/an/an/an/a7.525



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175425
PNG
(US9688680, 25)
Show SMILES Cc1nn(C)cc1-c1cc2c(ncnn2c1)N1CC(C1)C(=O)NCc1ccc(C)cc1
Show InChI InChI=1S/C23H25N7O/c1-15-4-6-17(7-5-15)9-24-23(31)19-10-29(11-19)22-21-8-18(12-30(21)26-14-25-22)20-13-28(3)27-16(20)2/h4-8,12-14,19H,9-11H2,1-3H3,(H,24,31)
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US Patent
n/an/a<1n/an/an/an/a7.525



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175428
PNG
(US9688680, 28)
Show SMILES CCc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2cnn(C)c2)cc1
Show InChI InChI=1S/C23H25N7O/c1-3-16-4-6-17(7-5-16)9-24-23(31)20-12-29(13-20)22-21-8-18(14-30(21)27-15-25-22)19-10-26-28(2)11-19/h4-8,10-11,14-15,20H,3,9,12-13H2,1-2H3,(H,24,31)
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n/an/a<1n/an/an/an/a7.525



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175429
PNG
(US9688680, 29)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2cn(C)nc2N)cc1
Show InChI InChI=1S/C22H24N8O/c1-14-3-5-15(6-4-14)8-24-22(31)17-9-29(10-17)21-19-7-16(11-30(19)26-13-25-21)18-12-28(2)27-20(18)23/h3-7,11-13,17H,8-10H2,1-2H3,(H2,23,27)(H,24,31)
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n/an/a<1n/an/an/an/a7.525



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175433
PNG
(US9688680, 33)
Show SMILES Cc1csc(c1)-c1cc2c(ncnn2c1)N1CC(C1)C(=O)NCc1ccc(C)cc1
Show InChI InChI=1S/C23H23N5OS/c1-15-3-5-17(6-4-15)9-24-23(29)19-10-27(11-19)22-20-8-18(12-28(20)26-14-25-22)21-7-16(2)13-30-21/h3-8,12-14,19H,9-11H2,1-2H3,(H,24,29)
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n/an/a<1n/an/an/an/a7.525



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175436
PNG
(US9688680, 36)
Show SMILES Cc1ccc(CNC(=O)C2CN(C2)c2ncnn3cc(cc23)-c2cnn(C)c2)c(F)c1
Show InChI InChI=1S/C22H22FN7O/c1-14-3-4-15(19(23)5-14)7-24-22(31)18-10-29(11-18)21-20-6-16(12-30(20)27-13-25-21)17-8-26-28(2)9-17/h3-6,8-9,12-13,18H,7,10-11H2,1-2H3,(H,24,31)
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n/an/a<1n/an/an/an/a7.525



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175438
PNG
(US9688680, 38)
Show SMILES Cn1cc(cn1)-c1cc2c(ncnn2c1)N1CC(C1)C(=O)NCc1ccc(Cl)cc1
Show InChI InChI=1S/C21H20ClN7O/c1-27-9-16(8-25-27)15-6-19-20(24-13-26-29(19)12-15)28-10-17(11-28)21(30)23-7-14-2-4-18(22)5-3-14/h2-6,8-9,12-13,17H,7,10-11H2,1H3,(H,23,30)
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n/an/a<1n/an/an/an/a7.525



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175443
PNG
(US9688680, 43)
Show SMILES CC(C)n1cc(cn1)-c1cc2c(ncnn2c1)N1CC(C1)C(=O)Nc1ccc(cc1)C#N
Show InChI InChI=1S/C23H22N8O/c1-15(2)30-13-18(9-26-30)17-7-21-22(25-14-27-31(21)12-17)29-10-19(11-29)23(32)28-20-5-3-16(8-24)4-6-20/h3-7,9,12-15,19H,10-11H2,1-2H3,(H,28,32)
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US Patent
n/an/a<1n/an/an/an/a7.525



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))
BDBM175445
PNG
(US9688680, 45)
Show SMILES COc1ccc(cc1)-c1cc2c(ncnn2c1)N1CC(C1)C(=O)NCc1ccc(C)cc1
Show InChI InChI=1S/C25H25N5O2/c1-17-3-5-18(6-4-17)12-26-25(31)21-13-29(14-21)24-23-11-20(15-30(23)28-16-27-24)19-7-9-22(32-2)10-8-19/h3-11,15-16,21H,12-14H2,1-2H3,(H,26,31)
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n/an/a<1n/an/an/an/a7.525



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of buffer (10...


US Patent US9688680 (2017)


BindingDB Entry DOI: 10.7270/Q2NV9GDQ
More data for this
Ligand-Target Pair
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