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Compile Data Set for Download or QSAR

Found 119 hits from Banyu Pharmaceutical Co.   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nociceptin receptor


(Homo sapiens (human))
BDBM29986
PNG
(arylpyrazole, 31)
Show SMILES Cc1c(CN[C@H]2CC[C@@H](F)C2)nn(c1-c1cnc(C)c(F)c1)-c1ncccc1Cl
Show InChI InChI=1S/C21H22ClF2N5/c1-12-19(11-27-16-6-5-15(23)9-16)28-29(21-17(22)4-3-7-25-21)20(12)14-8-18(24)13(2)26-10-14/h3-4,7-8,10,15-16,27H,5-6,9,11H2,1-2H3/t15-,16+/m1/s1
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n/an/a 0.520n/a 0.310n/an/an/an/a



Banyu Pharmaceutical Co.



Assay Description
Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...


Bioorg Med Chem Lett 19: 3627-31 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.116
BindingDB Entry DOI: 10.7270/Q289145G
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM29994
PNG
(2-Cyclohexylcarbonylbenzimidazole, 7e)
Show SMILES CCN1CCN(CC1)c1cc2[nH]c(nc2cc1Cl)C(=O)[C@]1(CC)CC[C@@](C)(O)CC1
Show InChI InChI=1S/C23H33ClN4O2/c1-4-23(8-6-22(3,30)7-9-23)20(29)21-25-17-14-16(24)19(15-18(17)26-21)28-12-10-27(5-2)11-13-28/h14-15,30H,4-13H2,1-3H3,(H,25,26)/t22-,23-
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n/an/a 0.800n/a 2.40n/an/a7.437



Banyu Pharmaceutical Co.



Assay Description
Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...


Bioorg Med Chem Lett 19: 3096-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.023
BindingDB Entry DOI: 10.7270/Q24J0CFR
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM29988
PNG
(benzimidazole analogue, 7h | benzimidazole derivat...)
Show SMILES CCN1CCN(CC1)c1cc2[nH]c(S[C@@]3(C)CC[C@@H](CC3)N(C)C(C)=O)nc2cc1Cl
Show InChI InChI=1S/C23H34ClN5OS/c1-5-28-10-12-29(13-11-28)21-15-20-19(14-18(21)24)25-22(26-20)31-23(3)8-6-17(7-9-23)27(4)16(2)30/h14-15,17H,5-13H2,1-4H3,(H,25,26)/t17-,23-
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n/an/a 0.810n/an/an/an/a7.437



Banyu Pharmaceutical Co.



Assay Description
Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...


Bioorg Med Chem Lett 19: 3096-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.023
BindingDB Entry DOI: 10.7270/Q24J0CFR
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM29988
PNG
(benzimidazole analogue, 7h | benzimidazole derivat...)
Show SMILES CCN1CCN(CC1)c1cc2[nH]c(S[C@@]3(C)CC[C@@H](CC3)N(C)C(C)=O)nc2cc1Cl
Show InChI InChI=1S/C23H34ClN5OS/c1-5-28-10-12-29(13-11-28)21-15-20-19(14-18(21)24)25-22(26-20)31-23(3)8-6-17(7-9-23)27(4)16(2)30/h14-15,17H,5-13H2,1-4H3,(H,25,26)/t17-,23-
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n/an/a 0.810n/a 1.30n/an/a7.437



Banyu Pharmaceutical Co.



Assay Description
Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...


Bioorg Med Chem Lett 19: 3100-3 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.022
BindingDB Entry DOI: 10.7270/Q20R9MRX
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM30012
PNG
(benzimidazole analogue, 7k)
Show SMILES CCN1CCN(CC1)c1cc2[nH]c(S[C@@]3(C)CC[C@@H](CC3)C(=O)NC)nc2cc1Cl
Show InChI InChI=1S/C22H32ClN5OS/c1-4-27-9-11-28(12-10-27)19-14-18-17(13-16(19)23)25-21(26-18)30-22(2)7-5-15(6-8-22)20(29)24-3/h13-15H,4-12H2,1-3H3,(H,24,29)(H,25,26)/t15-,22-
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n/an/a 1n/a 1.10n/an/a7.437



Banyu Pharmaceutical Co.



Assay Description
Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...


Bioorg Med Chem Lett 19: 3100-3 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.022
BindingDB Entry DOI: 10.7270/Q20R9MRX
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM29985
PNG
(arylpyrazole, 30)
Show SMILES Cc1c(CNC2CCCC2)nn(c1-c1cnc(C)c(F)c1)-c1ncccc1Cl
Show InChI InChI=1S/C21H23ClFN5/c1-13-19(12-26-16-6-3-4-7-16)27-28(21-17(22)8-5-9-24-21)20(13)15-10-18(23)14(2)25-11-15/h5,8-11,16,26H,3-4,6-7,12H2,1-2H3
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n/an/a 1.10n/a 1.20n/an/an/an/a



Banyu Pharmaceutical Co.



Assay Description
Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...


Bioorg Med Chem Lett 19: 3627-31 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.116
BindingDB Entry DOI: 10.7270/Q289145G
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM30017
PNG
(benzimidazole analogue, 7p)
Show SMILES CCN1CCN(CC1)c1cc2[nH]c(S[C@@]3(C)CC[C@@H](CC3)c3nnco3)nc2cc1Cl
Show InChI InChI=1S/C22H29ClN6OS/c1-3-28-8-10-29(11-9-28)19-13-18-17(12-16(19)23)25-21(26-18)31-22(2)6-4-15(5-7-22)20-27-24-14-30-20/h12-15H,3-11H2,1-2H3,(H,25,26)/t15-,22-
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n/an/a 1.10n/a 0.590n/an/a7.437



Banyu Pharmaceutical Co.



Assay Description
Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...


Bioorg Med Chem Lett 19: 3100-3 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.022
BindingDB Entry DOI: 10.7270/Q20R9MRX
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM30011
PNG
(benzimidazole analogue, 7j)
Show SMILES CCN1CCN(CC1)c1cc2[nH]c(S[C@@]3(C)CC[C@@H](CC3)N3CCCC3=O)nc2cc1Cl
Show InChI InChI=1S/C24H34ClN5OS/c1-3-28-11-13-29(14-12-28)21-16-20-19(15-18(21)25)26-23(27-20)32-24(2)8-6-17(7-9-24)30-10-4-5-22(30)31/h15-17H,3-14H2,1-2H3,(H,26,27)/t17-,24-
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n/an/a 1.40n/a 0.550n/an/a7.437



Banyu Pharmaceutical Co.



Assay Description
Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...


Bioorg Med Chem Lett 19: 3100-3 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.022
BindingDB Entry DOI: 10.7270/Q20R9MRX
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM29992
PNG
(2-Cyclohexylcarbonylbenzimidazole, 7c)
Show SMILES CCN1CCN(CC1)c1cc2[nH]c(nc2cc1Cl)C(=O)[C@]1(C)CC[C@@](C)(O)CC1
Show InChI InChI=1S/C22H31ClN4O2/c1-4-26-9-11-27(12-10-26)18-14-17-16(13-15(18)23)24-20(25-17)19(28)21(2)5-7-22(3,29)8-6-21/h13-14,29H,4-12H2,1-3H3,(H,24,25)/t21-,22-
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n/an/a 1.40n/a 1.30n/an/a7.437



Banyu Pharmaceutical Co.



Assay Description
Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...


Bioorg Med Chem Lett 19: 3096-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.023
BindingDB Entry DOI: 10.7270/Q24J0CFR
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM30016
PNG
(benzimidazole analogue, 7o)
Show SMILES CCN1CCN(CC1)c1cc2[nH]c(S[C@@]3(C)CC[C@@H](CC3)c3nc(C)no3)nc2cc1Cl
Show InChI InChI=1S/C23H31ClN6OS/c1-4-29-9-11-30(12-10-29)20-14-19-18(13-17(20)24)26-22(27-19)32-23(3)7-5-16(6-8-23)21-25-15(2)28-31-21/h13-14,16H,4-12H2,1-3H3,(H,26,27)/t16-,23-
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n/an/a 1.70n/a 0.910n/an/a7.437



Banyu Pharmaceutical Co.



Assay Description
Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...


Bioorg Med Chem Lett 19: 3100-3 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.022
BindingDB Entry DOI: 10.7270/Q20R9MRX
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM30018
PNG
(benzimidazole analogue, 7q)
Show SMILES CCN1CCN(CC1)c1cc2[nH]c(S[C@@]3(C)CC[C@@H](CC3)c3nnc(C)o3)nc2cc1Cl
Show InChI InChI=1S/C23H31ClN6OS/c1-4-29-9-11-30(12-10-29)20-14-19-18(13-17(20)24)25-22(26-19)32-23(3)7-5-16(6-8-23)21-28-27-15(2)31-21/h13-14,16H,4-12H2,1-3H3,(H,25,26)/t16-,23-
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n/an/a 1.80n/a 7.10n/an/a7.437



Banyu Pharmaceutical Co.



Assay Description
Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...


Bioorg Med Chem Lett 19: 3100-3 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.022
BindingDB Entry DOI: 10.7270/Q20R9MRX
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM30008
PNG
(benzimidazole analogue, 7g)
Show SMILES CCN1CCN(CC1)c1cc2[nH]c(S[C@@]3(C)CC[C@@H](CC3)NC(C)=O)nc2cc1Cl
Show InChI InChI=1S/C22H32ClN5OS/c1-4-27-9-11-28(12-10-27)20-14-19-18(13-17(20)23)25-21(26-19)30-22(3)7-5-16(6-8-22)24-15(2)29/h13-14,16H,4-12H2,1-3H3,(H,24,29)(H,25,26)/t16-,22-
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n/an/a 1.90n/a 1.10n/an/a7.437



Banyu Pharmaceutical Co.



Assay Description
Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...


Bioorg Med Chem Lett 19: 3100-3 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.022
BindingDB Entry DOI: 10.7270/Q20R9MRX
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM29990
PNG
(2-Cyclohexylcarbonylbenzimidazole, 7b)
Show SMILES CCN1CCN(CC1)c1cc2[nH]c(nc2cc1C)C(=O)[C@@]1(C)CC[C@@H](CC1)NC(=O)OC
Show InChI InChI=1S/C24H35N5O3/c1-5-28-10-12-29(13-11-28)20-15-19-18(14-16(20)2)26-22(27-19)21(30)24(3)8-6-17(7-9-24)25-23(31)32-4/h14-15,17H,5-13H2,1-4H3,(H,25,31)(H,26,27)/t17-,24-
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n/an/a 2n/a 5.30n/an/a7.437



Banyu Pharmaceutical Co.



Assay Description
Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...


Bioorg Med Chem Lett 19: 3096-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.023
BindingDB Entry DOI: 10.7270/Q24J0CFR
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM30010
PNG
(benzimidazole analogue, 7i)
Show SMILES CCN1CCN(CC1)c1cc2[nH]c(S[C@@]3(C)CC[C@@H](CC3)NS(C)(=O)=O)nc2cc1Cl
Show InChI InChI=1S/C21H32ClN5O2S2/c1-4-26-9-11-27(12-10-26)19-14-18-17(13-16(19)22)23-20(24-18)30-21(2)7-5-15(6-8-21)25-31(3,28)29/h13-15,25H,4-12H2,1-3H3,(H,23,24)/t15-,21-
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n/an/a 2.10n/a 1.80n/an/a7.437



Banyu Pharmaceutical Co.



Assay Description
Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...


Bioorg Med Chem Lett 19: 3100-3 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.022
BindingDB Entry DOI: 10.7270/Q20R9MRX
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM30014
PNG
(benzimidazole analogue, 7m)
Show SMILES CCN1CCN(CC1)c1cc2[nH]c(S[C@@]3(C)CC[C@@H](CC3)c3nnn(C)n3)nc2cc1Cl
Show InChI InChI=1S/C22H31ClN8S/c1-4-30-9-11-31(12-10-30)19-14-18-17(13-16(19)23)24-21(25-18)32-22(2)7-5-15(6-8-22)20-26-28-29(3)27-20/h13-15H,4-12H2,1-3H3,(H,24,25)/t15-,22-
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n/an/a 2.20n/a 0.900n/an/a7.437



Banyu Pharmaceutical Co.



Assay Description
Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...


Bioorg Med Chem Lett 19: 3100-3 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.022
BindingDB Entry DOI: 10.7270/Q20R9MRX
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM29987
PNG
(benzimidazole analogue, 7e | benzimidazole derivat...)
Show SMILES CCN1CCN(CC1)c1cc2[nH]c(S[C@@]3(C)CC[C@@H](CC3)NC(=O)OC)nc2cc1Cl
Show InChI InChI=1S/C22H32ClN5O2S/c1-4-27-9-11-28(12-10-27)19-14-18-17(13-16(19)23)25-20(26-18)31-22(2)7-5-15(6-8-22)24-21(29)30-3/h13-15H,4-12H2,1-3H3,(H,24,29)(H,25,26)/t15-,22-
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n/an/a 2.40n/a 0.720n/an/a7.437



Banyu Pharmaceutical Co.



Assay Description
Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...


Bioorg Med Chem Lett 19: 3096-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.023
BindingDB Entry DOI: 10.7270/Q24J0CFR
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM29987
PNG
(benzimidazole analogue, 7e | benzimidazole derivat...)
Show SMILES CCN1CCN(CC1)c1cc2[nH]c(S[C@@]3(C)CC[C@@H](CC3)NC(=O)OC)nc2cc1Cl
Show InChI InChI=1S/C22H32ClN5O2S/c1-4-27-9-11-28(12-10-27)19-14-18-17(13-16(19)23)25-20(26-18)31-22(2)7-5-15(6-8-22)24-21(29)30-3/h13-15H,4-12H2,1-3H3,(H,24,29)(H,25,26)/t15-,22-
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n/an/a 2.40n/a 0.720n/an/a7.437



Banyu Pharmaceutical Co.



Assay Description
Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...


Bioorg Med Chem Lett 19: 3100-3 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.022
BindingDB Entry DOI: 10.7270/Q20R9MRX
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM29983
PNG
(arylpyrazole, 28)
Show SMILES Cc1c(CN[C@H]2CC[C@@H](F)C2)nn(c1-c1ccc(C)nc1)-c1ncccc1Cl
Show InChI InChI=1S/C21H23ClFN5/c1-13-5-6-15(11-25-13)20-14(2)19(12-26-17-8-7-16(23)10-17)27-28(20)21-18(22)4-3-9-24-21/h3-6,9,11,16-17,26H,7-8,10,12H2,1-2H3/t16-,17+/m1/s1
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n/an/a 2.5n/a 1n/an/an/an/a



Banyu Pharmaceutical Co.



Assay Description
Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...


Bioorg Med Chem Lett 19: 3627-31 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.116
BindingDB Entry DOI: 10.7270/Q289145G
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM29995
PNG
(CHEMBL494350 | benzimidazole-based antagonist, 1)
Show SMILES C[C@@H]1CN(CCO)CCN1c1cc2[nH]c(SC(C)(C)C)nc2cc1Cl
Show InChI InChI=1S/C18H27ClN4OS/c1-12-11-22(7-8-24)5-6-23(12)16-10-15-14(9-13(16)19)20-17(21-15)25-18(2,3)4/h9-10,12,24H,5-8,11H2,1-4H3,(H,20,21)/t12-/m1/s1
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n/an/a 2.60n/a 0.650n/an/a7.437



Banyu Pharmaceutical Co.



Assay Description
Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...


Bioorg Med Chem Lett 19: 3100-3 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.022
BindingDB Entry DOI: 10.7270/Q20R9MRX
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM30177
PNG
(2-aminobenzimidazole-based compound, 25)
Show SMILES CC(C)N(C)c1nc2ccc(NC(=O)c3cnc(cn3)-c3ccc(F)cc3)cc2[nH]1
Show InChI InChI=1S/C22H21FN6O/c1-13(2)29(3)22-27-17-9-8-16(10-18(17)28-22)26-21(30)20-12-24-19(11-25-20)14-4-6-15(23)7-5-14/h4-13H,1-3H3,(H,26,30)(H,27,28)
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n/an/a 2.70n/an/an/an/a7.422



Banyu Pharmaceutical Co.



Assay Description
Compounds were evaluated for their binding affinity to the membranes of CHO-K1 cells expressing human MCH1R (hMCH1R) in a competition binding assay w...


Bioorg Med Chem Lett 19: 3568-72 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.147
BindingDB Entry DOI: 10.7270/Q2C24TR1
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM30172
PNG
(2-aminobenzimidazole-based compound, 20)
Show SMILES CC(C)N(C)c1nc2ccc(NC(=O)c3ccc(cc3)-c3ccc(cn3)C(F)(F)F)cc2[nH]1
Show InChI InChI=1S/C24H22F3N5O/c1-14(2)32(3)23-30-20-11-9-18(12-21(20)31-23)29-22(33)16-6-4-15(5-7-16)19-10-8-17(13-28-19)24(25,26)27/h4-14H,1-3H3,(H,29,33)(H,30,31)
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n/an/a 3.10n/an/an/an/a7.422



Banyu Pharmaceutical Co.



Assay Description
Compounds were evaluated for their binding affinity to the membranes of CHO-K1 cells expressing human MCH1R (hMCH1R) in a competition binding assay w...


Bioorg Med Chem Lett 19: 3568-72 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.147
BindingDB Entry DOI: 10.7270/Q2C24TR1
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM30164
PNG
(2-aminobenzimidazole-based compound, 12)
Show SMILES CN(C1CCCC1)c1nc2ccc(NC(=O)CCc3ccc(cc3)C(F)(F)F)cc2[nH]1
Show InChI InChI=1S/C23H25F3N4O/c1-30(18-4-2-3-5-18)22-28-19-12-11-17(14-20(19)29-22)27-21(31)13-8-15-6-9-16(10-7-15)23(24,25)26/h6-7,9-12,14,18H,2-5,8,13H2,1H3,(H,27,31)(H,28,29)
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n/an/a 4n/a 22n/an/a7.422



Banyu Pharmaceutical Co.



Assay Description
Compounds were evaluated for their binding affinity to the membranes of CHO-K1 cells expressing human MCH1R (hMCH1R) in a competition binding assay w...


Bioorg Med Chem Lett 19: 3568-72 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.147
BindingDB Entry DOI: 10.7270/Q2C24TR1
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM29974
PNG
(arylpyrazole, 19)
Show SMILES Cc1c(CNC2CCCC2)nn(c1-c1ccc(C)nc1)-c1ncccc1Cl
Show InChI InChI=1S/C21H24ClN5/c1-14-9-10-16(12-24-14)20-15(2)19(13-25-17-6-3-4-7-17)26-27(20)21-18(22)8-5-11-23-21/h5,8-12,17,25H,3-4,6-7,13H2,1-2H3
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n/an/a 4n/a 4.70n/an/a7.437



Banyu Pharmaceutical Co.



Assay Description
Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...


Bioorg Med Chem Lett 19: 3627-31 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.116
BindingDB Entry DOI: 10.7270/Q289145G
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM30004
PNG
(benzimidazole analogue, 7c)
Show SMILES CCOC(=O)N1CCC(C)(CC1)Sc1nc2cc(Cl)c(cc2[nH]1)N1CCN(CC)CC1
Show InChI InChI=1S/C22H32ClN5O2S/c1-4-26-10-12-27(13-11-26)19-15-18-17(14-16(19)23)24-20(25-18)31-22(3)6-8-28(9-7-22)21(29)30-5-2/h14-15H,4-13H2,1-3H3,(H,24,25)
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n/an/a 4.30n/a 1.10n/an/a7.437



Banyu Pharmaceutical Co.



Assay Description
Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...


Bioorg Med Chem Lett 19: 3100-3 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.022
BindingDB Entry DOI: 10.7270/Q20R9MRX
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM30174
PNG
(2-aminobenzimidazole-based compound, 22)
Show SMILES CC(C)N(C)c1nc2ccc(NC(=O)c3ccc(nc3)-c3ccc(F)cc3)cc2[nH]1
Show InChI InChI=1S/C23H22FN5O/c1-14(2)29(3)23-27-20-11-9-18(12-21(20)28-23)26-22(30)16-6-10-19(25-13-16)15-4-7-17(24)8-5-15/h4-14H,1-3H3,(H,26,30)(H,27,28)
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n/an/a 5.5n/an/an/an/a7.422



Banyu Pharmaceutical Co.



Assay Description
Compounds were evaluated for their binding affinity to the membranes of CHO-K1 cells expressing human MCH1R (hMCH1R) in a competition binding assay w...


Bioorg Med Chem Lett 19: 3568-72 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.147
BindingDB Entry DOI: 10.7270/Q2C24TR1
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM29989
PNG
(2-Cyclohexylcarbonylbenzimidazole, 7a)
Show SMILES CCN1CCN(CC1)c1cc2[nH]c(nc2cc1Cl)C(=O)[C@@]1(C)CC[C@@H](CC1)NC(=O)OC
Show InChI InChI=1S/C23H32ClN5O3/c1-4-28-9-11-29(12-10-28)19-14-18-17(13-16(19)24)26-21(27-18)20(30)23(2)7-5-15(6-8-23)25-22(31)32-3/h13-15H,4-12H2,1-3H3,(H,25,31)(H,26,27)/t15-,23-
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n/an/a 5.70n/a 7.5n/an/a7.437



Banyu Pharmaceutical Co.



Assay Description
Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...


Bioorg Med Chem Lett 19: 3096-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.023
BindingDB Entry DOI: 10.7270/Q24J0CFR
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM30156
PNG
(2-aminobenzimidazole-based compound, 8)
Show SMILES CC(C)N(C)c1nc2ccc(NC(=O)CCc3ccc(cc3)C(F)(F)F)cc2[nH]1
Show InChI InChI=1S/C21H23F3N4O/c1-13(2)28(3)20-26-17-10-9-16(12-18(17)27-20)25-19(29)11-6-14-4-7-15(8-5-14)21(22,23)24/h4-5,7-10,12-13H,6,11H2,1-3H3,(H,25,29)(H,26,27)
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n/an/a 5.90n/a 21n/an/a7.422



Banyu Pharmaceutical Co.



Assay Description
Compounds were evaluated for their binding affinity to the membranes of CHO-K1 cells expressing human MCH1R (hMCH1R) in a competition binding assay w...


Bioorg Med Chem Lett 19: 3568-72 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.147
BindingDB Entry DOI: 10.7270/Q2C24TR1
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM30165
PNG
(2-aminobenzimidazole-based compound, 13)
Show SMILES CN(C1CCCCC1)c1nc2ccc(NC(=O)CCc3ccc(cc3)C(F)(F)F)cc2[nH]1
Show InChI InChI=1S/C24H27F3N4O/c1-31(19-5-3-2-4-6-19)23-29-20-13-12-18(15-21(20)30-23)28-22(32)14-9-16-7-10-17(11-8-16)24(25,26)27/h7-8,10-13,15,19H,2-6,9,14H2,1H3,(H,28,32)(H,29,30)
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n/an/a 6.70n/a 27n/an/a7.422



Banyu Pharmaceutical Co.



Assay Description
Compounds were evaluated for their binding affinity to the membranes of CHO-K1 cells expressing human MCH1R (hMCH1R) in a competition binding assay w...


Bioorg Med Chem Lett 19: 3568-72 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.147
BindingDB Entry DOI: 10.7270/Q2C24TR1
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM30013
PNG
(benzimidazole analogue, 7l)
Show SMILES CCN1CCN(CC1)c1cc2[nH]c(S[C@@]3(C)CC[C@@H](CC3)S(C)(=O)=O)nc2cc1Cl
Show InChI InChI=1S/C21H31ClN4O2S2/c1-4-25-9-11-26(12-10-25)19-14-18-17(13-16(19)22)23-20(24-18)29-21(2)7-5-15(6-8-21)30(3,27)28/h13-15H,4-12H2,1-3H3,(H,23,24)/t15-,21-
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n/an/a 6.90n/a 4n/an/a7.437



Banyu Pharmaceutical Co.



Assay Description
Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...


Bioorg Med Chem Lett 19: 3100-3 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.022
BindingDB Entry DOI: 10.7270/Q20R9MRX
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM30015
PNG
(benzimidazole analogue, 7n)
Show SMILES CCN1CCN(CC1)c1cc2[nH]c(S[C@@]3(C)CC[C@@H](CC3)c3nnnn3C)nc2cc1Cl
Show InChI InChI=1S/C22H31ClN8S/c1-4-30-9-11-31(12-10-30)19-14-18-17(13-16(19)23)24-21(25-18)32-22(2)7-5-15(6-8-22)20-26-27-28-29(20)3/h13-15H,4-12H2,1-3H3,(H,24,25)/t15-,22-
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n/an/a 7.40n/a 3.70n/an/a7.437



Banyu Pharmaceutical Co.



Assay Description
Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...


Bioorg Med Chem Lett 19: 3100-3 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.022
BindingDB Entry DOI: 10.7270/Q20R9MRX
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM29981
PNG
(arylpyrazole, 26)
Show SMILES Cc1c(CNC2CCCC2)nn(c1-c1ccc(C)nc1)-c1ncc(Cl)cc1Cl
Show InChI InChI=1S/C21H23Cl2N5/c1-13-7-8-15(10-24-13)20-14(2)19(12-25-17-5-3-4-6-17)27-28(20)21-18(23)9-16(22)11-26-21/h7-11,17,25H,3-6,12H2,1-2H3
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n/an/a 8.20n/an/an/an/a7.437



Banyu Pharmaceutical Co.



Assay Description
Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...


Bioorg Med Chem Lett 19: 3627-31 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.116
BindingDB Entry DOI: 10.7270/Q289145G
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM30173
PNG
(2-aminobenzimidazole-based compound, 21)
Show SMILES CC(C)N(C)c1nc2ccc(NC(=O)c3ccc(nc3)-c3ccccc3)cc2[nH]1
Show InChI InChI=1S/C23H23N5O/c1-15(2)28(3)23-26-20-12-10-18(13-21(20)27-23)25-22(29)17-9-11-19(24-14-17)16-7-5-4-6-8-16/h4-15H,1-3H3,(H,25,29)(H,26,27)
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n/an/a 8.80n/an/an/an/a7.422



Banyu Pharmaceutical Co.



Assay Description
Compounds were evaluated for their binding affinity to the membranes of CHO-K1 cells expressing human MCH1R (hMCH1R) in a competition binding assay w...


Bioorg Med Chem Lett 19: 3568-72 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.147
BindingDB Entry DOI: 10.7270/Q2C24TR1
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM29996
PNG
(benzimidazole analogue, 5a)
Show SMILES CCN1CCN([C@H](C)C1)c1cc2[nH]c(SC(C)(C)C)nc2cc1Cl
Show InChI InChI=1S/C18H27ClN4S/c1-6-22-7-8-23(12(2)11-22)16-10-15-14(9-13(16)19)20-17(21-15)24-18(3,4)5/h9-10,12H,6-8,11H2,1-5H3,(H,20,21)/t12-/m1/s1
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n/an/a 9.20n/a 2.90n/an/a7.437



Banyu Pharmaceutical Co.



Assay Description
Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...


Bioorg Med Chem Lett 19: 3100-3 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.022
BindingDB Entry DOI: 10.7270/Q20R9MRX
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM29984
PNG
(arylpyrazole, 29)
Show SMILES Cc1c(CNC2CCC(F)(F)C2)nn(c1-c1ccc(C)nc1)-c1ncccc1Cl
Show InChI InChI=1S/C21H22ClF2N5/c1-13-5-6-15(11-26-13)19-14(2)18(12-27-16-7-8-21(23,24)10-16)28-29(19)20-17(22)4-3-9-25-20/h3-6,9,11,16,27H,7-8,10,12H2,1-2H3
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n/an/a 9.30n/a 4.5n/an/an/an/a



Banyu Pharmaceutical Co.



Assay Description
Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...


Bioorg Med Chem Lett 19: 3627-31 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.116
BindingDB Entry DOI: 10.7270/Q289145G
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM30005
PNG
(benzimidazole analogue, 7d)
Show SMILES CCN1CCN(CC1)c1cc2[nH]c(S[C@]3(C)CC[C@@H](CC3)NC(=O)OC)nc2cc1Cl
Show InChI InChI=1S/C22H32ClN5O2S/c1-4-27-9-11-28(12-10-27)19-14-18-17(13-16(19)23)25-20(26-18)31-22(2)7-5-15(6-8-22)24-21(29)30-3/h13-15H,4-12H2,1-3H3,(H,24,29)(H,25,26)/t15-,22+
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n/an/a 9.5n/a 2.10n/an/a7.437



Banyu Pharmaceutical Co.



Assay Description
Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...


Bioorg Med Chem Lett 19: 3100-3 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.022
BindingDB Entry DOI: 10.7270/Q20R9MRX
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM29991
PNG
(2-Cyclohexylcarbonylbenzimidazole, 9)
Show SMILES CCN1CCN(CC1)c1cc2[nH]c(nc2cc1Cl)C(=O)C1(C)CCC(=O)CC1
Show InChI InChI=1S/C21H27ClN4O2/c1-3-25-8-10-26(11-9-25)18-13-17-16(12-15(18)22)23-20(24-17)19(28)21(2)6-4-14(27)5-7-21/h12-13H,3-11H2,1-2H3,(H,23,24)
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n/an/a 9.90n/a 38n/an/a7.437



Banyu Pharmaceutical Co.



Assay Description
Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...


Bioorg Med Chem Lett 19: 3096-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.023
BindingDB Entry DOI: 10.7270/Q24J0CFR
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM29982
PNG
(arylpyrazole, 27)
Show SMILES Cc1c(CNC2CCCC2F)nn(c1-c1ccc(C)nc1)-c1ncccc1Cl
Show InChI InChI=1S/C21H23ClFN5/c1-13-8-9-15(11-25-13)20-14(2)19(12-26-18-7-3-6-17(18)23)27-28(20)21-16(22)5-4-10-24-21/h4-5,8-11,17-18,26H,3,6-7,12H2,1-2H3
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n/an/a 11n/a 7.10n/an/an/an/a



Banyu Pharmaceutical Co.



Assay Description
Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...


Bioorg Med Chem Lett 19: 3627-31 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.116
BindingDB Entry DOI: 10.7270/Q289145G
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM29973
PNG
(arylpyrazole, 18)
Show SMILES Cc1c(CNC2CCCC2)nn(c1-c1ccc(Cl)nc1)-c1ncccc1Cl
Show InChI InChI=1S/C20H21Cl2N5/c1-13-17(12-24-15-5-2-3-6-15)26-27(20-16(21)7-4-10-23-20)19(13)14-8-9-18(22)25-11-14/h4,7-11,15,24H,2-3,5-6,12H2,1H3
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n/an/a 11n/a 12n/an/a7.437



Banyu Pharmaceutical Co.



Assay Description
Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...


Bioorg Med Chem Lett 19: 3627-31 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.116
BindingDB Entry DOI: 10.7270/Q289145G
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM30161
PNG
(2-aminobenzimidazole-based compound, 9)
Show SMILES CN(C)c1nc2ccc(NC(=O)CCc3ccc(cc3)C(F)(F)F)cc2[nH]1
Show InChI InChI=1S/C19H19F3N4O/c1-26(2)18-24-15-9-8-14(11-16(15)25-18)23-17(27)10-5-12-3-6-13(7-4-12)19(20,21)22/h3-4,6-9,11H,5,10H2,1-2H3,(H,23,27)(H,24,25)
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n/an/a 12n/an/an/an/a7.422



Banyu Pharmaceutical Co.



Assay Description
Compounds were evaluated for their binding affinity to the membranes of CHO-K1 cells expressing human MCH1R (hMCH1R) in a competition binding assay w...


Bioorg Med Chem Lett 19: 3568-72 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.147
BindingDB Entry DOI: 10.7270/Q2C24TR1
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM29977
PNG
(arylpyrazole, 22)
Show SMILES Cc1c(CNC2CCCC2)nn(c1-c1cncc(C)c1)-c1ncccc1Cl
Show InChI InChI=1S/C21H24ClN5/c1-14-10-16(12-23-11-14)20-15(2)19(13-25-17-6-3-4-7-17)26-27(20)21-18(22)8-5-9-24-21/h5,8-12,17,25H,3-4,6-7,13H2,1-2H3
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n/an/a 13n/an/an/an/a7.437



Banyu Pharmaceutical Co.



Assay Description
Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...


Bioorg Med Chem Lett 19: 3627-31 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.116
BindingDB Entry DOI: 10.7270/Q289145G
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM30176
PNG
(2-aminobenzimidazole-based compound, 24)
Show SMILES CC(C)N(C)c1nc2ccc(NC(=O)c3ncc(cn3)-c3ccc(F)cc3)cc2[nH]1
Show InChI InChI=1S/C22H21FN6O/c1-13(2)29(3)22-27-18-9-8-17(10-19(18)28-22)26-21(30)20-24-11-15(12-25-20)14-4-6-16(23)7-5-14/h4-13H,1-3H3,(H,26,30)(H,27,28)
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n/an/a 15n/an/an/an/a7.422



Banyu Pharmaceutical Co.



Assay Description
Compounds were evaluated for their binding affinity to the membranes of CHO-K1 cells expressing human MCH1R (hMCH1R) in a competition binding assay w...


Bioorg Med Chem Lett 19: 3568-72 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.147
BindingDB Entry DOI: 10.7270/Q2C24TR1
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM30007
PNG
(Racemate | benzimidazole analogue, 7f)
Show SMILES CCN1CCN(CC1)c1cc2[nH]c(S[C@@]3(C)CC[C@@H](C3)NC(=O)OC)nc2cc1Cl
Show InChI InChI=1S/C21H30ClN5O2S/c1-4-26-7-9-27(10-8-26)18-12-17-16(11-15(18)22)24-19(25-17)30-21(2)6-5-14(13-21)23-20(28)29-3/h11-12,14H,4-10,13H2,1-3H3,(H,23,28)(H,24,25)/t14-,21-/m0/s1
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n/an/a 16n/a 46n/an/a7.437



Banyu Pharmaceutical Co.



Assay Description
Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...


Bioorg Med Chem Lett 19: 3100-3 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.022
BindingDB Entry DOI: 10.7270/Q20R9MRX
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM30162
PNG
(2-aminobenzimidazole-based compound, 10)
Show SMILES CCN(C)c1nc2ccc(NC(=O)CCc3ccc(cc3)C(F)(F)F)cc2[nH]1
Show InChI InChI=1S/C20H21F3N4O/c1-3-27(2)19-25-16-10-9-15(12-17(16)26-19)24-18(28)11-6-13-4-7-14(8-5-13)20(21,22)23/h4-5,7-10,12H,3,6,11H2,1-2H3,(H,24,28)(H,25,26)
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n/an/a 19n/an/an/an/a7.422



Banyu Pharmaceutical Co.



Assay Description
Compounds were evaluated for their binding affinity to the membranes of CHO-K1 cells expressing human MCH1R (hMCH1R) in a competition binding assay w...


Bioorg Med Chem Lett 19: 3568-72 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.147
BindingDB Entry DOI: 10.7270/Q2C24TR1
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM30003
PNG
(benzimidazole analogue, 7b)
Show SMILES CCN1CCN(CC1)c1cc2[nH]c(SC(C)(C)CCNC(=O)OC)nc2cc1Cl
Show InChI InChI=1S/C20H30ClN5O2S/c1-5-25-8-10-26(11-9-25)17-13-16-15(12-14(17)21)23-18(24-16)29-20(2,3)6-7-22-19(27)28-4/h12-13H,5-11H2,1-4H3,(H,22,27)(H,23,24)
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n/an/a 21n/a 8.60n/an/a7.437



Banyu Pharmaceutical Co.



Assay Description
Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...


Bioorg Med Chem Lett 19: 3100-3 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.022
BindingDB Entry DOI: 10.7270/Q20R9MRX
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM30002
PNG
(benzimidazole analogue, 7a)
Show SMILES CCN1CCN(CC1)c1cc2[nH]c(SC(C)(C)C)nc2cc1Cl
Show InChI InChI=1S/C17H25ClN4S/c1-5-21-6-8-22(9-7-21)15-11-14-13(10-12(15)18)19-16(20-14)23-17(2,3)4/h10-11H,5-9H2,1-4H3,(H,19,20)
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n/an/a 22n/an/an/an/a7.437



Banyu Pharmaceutical Co.



Assay Description
Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...


Bioorg Med Chem Lett 19: 3100-3 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.022
BindingDB Entry DOI: 10.7270/Q20R9MRX
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM30168
PNG
(2-aminobenzimidazole-based compound, 16)
Show SMILES CN(C1CCN(C)CC1)c1nc2ccc(NC(=O)CCc3ccc(cc3)C(F)(F)F)cc2[nH]1
Show InChI InChI=1S/C24H28F3N5O/c1-31-13-11-19(12-14-31)32(2)23-29-20-9-8-18(15-21(20)30-23)28-22(33)10-5-16-3-6-17(7-4-16)24(25,26)27/h3-4,6-9,15,19H,5,10-14H2,1-2H3,(H,28,33)(H,29,30)
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n/an/a 23n/an/an/an/a7.422



Banyu Pharmaceutical Co.



Assay Description
Compounds were evaluated for their binding affinity to the membranes of CHO-K1 cells expressing human MCH1R (hMCH1R) in a competition binding assay w...


Bioorg Med Chem Lett 19: 3568-72 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.147
BindingDB Entry DOI: 10.7270/Q2C24TR1
More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (human))
BDBM29997
PNG
(benzimidazole analogue, 5b)
Show SMILES C[C@@H]1CN(CC(F)F)CCN1c1cc2[nH]c(SC(C)(C)C)nc2cc1Cl
Show InChI InChI=1S/C18H25ClF2N4S/c1-11-9-24(10-16(20)21)5-6-25(11)15-8-14-13(7-12(15)19)22-17(23-14)26-18(2,3)4/h7-8,11,16H,5-6,9-10H2,1-4H3,(H,22,23)/t11-/m1/s1
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n/an/a 23n/an/an/an/a7.437



Banyu Pharmaceutical Co.



Assay Description
Compounds were tested for their inhibitory effects on ligand binding to the human ORL1 receptor. Bound and free radioligands are separated by filtra...


Bioorg Med Chem Lett 19: 3100-3 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.022
BindingDB Entry DOI: 10.7270/Q20R9MRX
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM29968
PNG
(arylpyrazole, 13)
Show SMILES Cc1c(CNC2CCCC2)nn(c1-c1ccc(Cl)cc1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C22H22Cl3N3/c1-14-20(13-26-18-4-2-3-5-18)27-28(21-11-10-17(24)12-19(21)25)22(14)15-6-8-16(23)9-7-15/h6-12,18,26H,2-5,13H2,1H3
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MMDB

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n/an/a 23n/an/an/an/a7.422



Banyu Pharmaceutical Co.



Assay Description
Binding affinity to the hERG K+ channel was measured by displacement of [35S]-radiolabeled MK499 in membranes derived from HEK 293 cells stably trans...


Bioorg Med Chem Lett 19: 3627-31 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.116
BindingDB Entry DOI: 10.7270/Q289145G
More data for this
Ligand-Target Pair
Voltage-gated potassium channel


(Homo sapiens (human))
BDBM29960
PNG
(arylpyrazole, 1)
Show SMILES CC(C)NCc1nn(c(c1C)-c1ccc(Cl)cc1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C20H20Cl3N3/c1-12(2)24-11-18-13(3)20(14-4-6-15(21)7-5-14)26(25-18)19-9-8-16(22)10-17(19)23/h4-10,12,24H,11H2,1-3H3
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n/an/a 23n/an/an/an/a7.422



Banyu Pharmaceutical Co.



Assay Description
Binding affinity to the hERG K+ channel was measured by displacement of [35S]-radiolabeled MK499 in membranes derived from HEK 293 cells stably trans...


Bioorg Med Chem Lett 19: 3627-31 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.116
BindingDB Entry DOI: 10.7270/Q289145G
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM30163
PNG
(2-aminobenzimidazole-based compound, 11)
Show SMILES CN(C1CC1)c1nc2ccc(NC(=O)CCc3ccc(cc3)C(F)(F)F)cc2[nH]1
Show InChI InChI=1S/C21H21F3N4O/c1-28(16-8-9-16)20-26-17-10-7-15(12-18(17)27-20)25-19(29)11-4-13-2-5-14(6-3-13)21(22,23)24/h2-3,5-7,10,12,16H,4,8-9,11H2,1H3,(H,25,29)(H,26,27)
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n/an/a 24n/an/an/an/a7.422



Banyu Pharmaceutical Co.



Assay Description
Compounds were evaluated for their binding affinity to the membranes of CHO-K1 cells expressing human MCH1R (hMCH1R) in a competition binding assay w...


Bioorg Med Chem Lett 19: 3568-72 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.147
BindingDB Entry DOI: 10.7270/Q2C24TR1
More data for this
Ligand-Target Pair
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