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Found 3850 hits from Bayer Intellectual Property GmbH   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM165927
PNG
(US10214524, Example 75 | US9067931, 75)
Show SMILES OC(=O)c1cccc(c1)-c1cccc2cc(sc12)C(=O)N[C@H]1CN2CCC1CC2
Show InChI InChI=1/C23H22N2O3S/c26-22(24-19-13-25-9-7-14(19)8-10-25)20-12-16-4-2-6-18(21(16)29-20)15-3-1-5-17(11-15)23(27)28/h1-6,11-12,14,19H,7-10,13H2,(H,24,26)(H,27,28)/t19-/s2
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US Patent
<0.100<-12.7n/an/an/an/an/a7.44



Bayer Intellectual Property GmbH

US Patent


Assay Description
The [3H]-methyllycaconitine binding assay is a modification of the method described by Davies et al. in Neuropharmacol. 1999, 38, 679-690.Rat brain t...


US Patent US9067931 (2015)


BindingDB Entry DOI: 10.7270/Q2M907F1
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM165927
PNG
(US10214524, Example 75 | US9067931, 75)
Show SMILES OC(=O)c1cccc(c1)-c1cccc2cc(sc12)C(=O)N[C@H]1CN2CCC1CC2
Show InChI InChI=1/C23H22N2O3S/c26-22(24-19-13-25-9-7-14(19)8-10-25)20-12-16-4-2-6-18(21(16)29-20)15-3-1-5-17(11-15)23(27)28/h1-6,11-12,14,19H,7-10,13H2,(H,24,26)(H,27,28)/t19-/s2
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<0.100n/an/an/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Rat brain tissue (hippocampus or whole brain) is homogenized in homogenization buffer (10% w/v, 0.32 M sucrose, 1 mM EDTA, 0.1 mM phenylmethylsulphon...


US Patent US10214524 (2019)


Article DOI: 10.1021/jm061329j
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM125050
PNG
(US8772511, 11 | US9714242, 11)
Show SMILES Fc1cccc(F)c1NC(=O)Nc1ccc2cc(sc2c1)C(=O)N[C@H]1CN2CCC1CC2
Show InChI InChI=1/C23H22F2N4O2S/c24-16-2-1-3-17(25)21(16)28-23(31)26-15-5-4-14-10-20(32-19(14)11-15)22(30)27-18-12-29-8-6-13(18)7-9-29/h1-5,10-11,13,18H,6-9,12H2,(H,27,30)(H2,26,28,31)/t18-/s2
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0.400 -11.9n/an/an/an/an/a7.44



Bayer Intellectual Property GmbH

US Patent


Assay Description
Rat brain tissue (hippocampus or whole brain) is homogenized in aqueous homogenization buffer (10% w/v, 0.32 M sucrose, 1 mM EDTA, 0.1 mM phenylmethy...


US Patent US8772511 (2014)


BindingDB Entry DOI: 10.7270/Q2GQ6WF2
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM125050
PNG
(US8772511, 11 | US9714242, 11)
Show SMILES Fc1cccc(F)c1NC(=O)Nc1ccc2cc(sc2c1)C(=O)N[C@H]1CN2CCC1CC2
Show InChI InChI=1/C23H22F2N4O2S/c24-16-2-1-3-17(25)21(16)28-23(31)26-15-5-4-14-10-20(32-19(14)11-15)22(30)27-18-12-29-8-6-13(18)7-9-29/h1-5,10-11,13,18H,6-9,12H2,(H,27,30)(H2,26,28,31)/t18-/s2
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0.400n/an/an/an/an/an/a7.4n/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
The [3H]-methyllycaconitine binding assay is a modification of the method described by Davies et al. in Neuropharmacol, 1999, 38, 679-690.Rat brain t...


US Patent US9714242 (2017)


Article DOI: 10.1021/jm960441m
BindingDB Entry DOI: 10.7270/Q2M61N83
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM165926
PNG
(US10214524, Example 73 | US9067931, 73)
Show SMILES NCc1ccccc1-c1cccc2cc(sc12)C(=O)N[C@H]1CN2CCC1CC2
Show InChI InChI=1/C23H25N3OS/c24-13-17-4-1-2-6-18(17)19-7-3-5-16-12-21(28-22(16)19)23(27)25-20-14-26-10-8-15(20)9-11-26/h1-7,12,15,20H,8-11,13-14,24H2,(H,25,27)/t20-/s2
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<1n/an/an/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Rat brain tissue (hippocampus or whole brain) is homogenized in homogenization buffer (10% w/v, 0.32 M sucrose, 1 mM EDTA, 0.1 mM phenylmethylsulphon...


US Patent US10214524 (2019)


Article DOI: 10.1021/jm061329j
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM119804
PNG
(US8691840, 7)
Show SMILES NS(=O)(=O)c1ccc(cc1)-c1ccc(NC(=O)[C@H]2CN3CCC2CC3)cc1
Show InChI InChI=1/C20H23N3O3S/c21-27(25,26)18-7-3-15(4-8-18)14-1-5-17(6-2-14)22-20(24)19-13-23-11-9-16(19)10-12-23/h1-8,16,19H,9-13H2,(H,22,24)(H2,21,25,26)/t19-/s2
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<1<-11.2n/an/an/an/an/a7.40



Bayer Intellectual Property GmbH

US Patent


Assay Description
The [3H]-methyllycaconitine binding assay is a modification of the method described by Davies et al. (Neuropharmacol. 1999, 38, 679-690). The P2 pell...


US Patent US8691840 (2014)


BindingDB Entry DOI: 10.7270/Q2M32TFR
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM165926
PNG
(US10214524, Example 73 | US9067931, 73)
Show SMILES NCc1ccccc1-c1cccc2cc(sc12)C(=O)N[C@H]1CN2CCC1CC2
Show InChI InChI=1/C23H25N3OS/c24-13-17-4-1-2-6-18(17)19-7-3-5-16-12-21(28-22(16)19)23(27)25-20-14-26-10-8-15(20)9-11-26/h1-7,12,15,20H,8-11,13-14,24H2,(H,25,27)/t20-/s2
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<1<-11.4n/an/an/an/an/a7.44



Bayer Intellectual Property GmbH

US Patent


Assay Description
The [3H]-methyllycaconitine binding assay is a modification of the method described by Davies et al. in Neuropharmacol. 1999, 38, 679-690.Rat brain t...


US Patent US9067931 (2015)


BindingDB Entry DOI: 10.7270/Q2M907F1
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM125053
PNG
(US8772511, 22)
Show SMILES COc1ccc(NC(=O)Nc2ccc3cc(oc3c2)C(=O)N[C@H]2CN3CCC2CC3)cc1
Show InChI InChI=1/C24H26N4O4/c1-31-19-6-4-17(5-7-19)25-24(30)26-18-3-2-16-12-22(32-21(16)13-18)23(29)27-20-14-28-10-8-15(20)9-11-28/h2-7,12-13,15,20H,8-11,14H2,1H3,(H,27,29)(H2,25,26,30)/t20-/s2
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<1<-11.4n/an/an/an/an/a7.44



Bayer Intellectual Property GmbH

US Patent


Assay Description
Rat brain tissue (hippocampus or whole brain) is homogenized in aqueous homogenization buffer (10% w/v, 0.32 M sucrose, 1 mM EDTA, 0.1 mM phenylmethy...


US Patent US8772511 (2014)


BindingDB Entry DOI: 10.7270/Q2GQ6WF2
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM119803
PNG
(US8691840, 5)
Show SMILES O=C(Nc1ccc(cc1)-c1ccc(NS(=O)(=O)c2ccccc2)cc1)[C@H]1CN2CCC1CC2
Show InChI InChI=1/C26H27N3O3S/c30-26(25-18-29-16-14-21(25)15-17-29)27-22-10-6-19(7-11-22)20-8-12-23(13-9-20)28-33(31,32)24-4-2-1-3-5-24/h1-13,21,25,28H,14-18H2,(H,27,30)/t25-/s2
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<1<-11.2n/an/an/an/an/a7.40



Bayer Intellectual Property GmbH

US Patent


Assay Description
The [3H]-methyllycaconitine binding assay is a modification of the method described by Davies et al. (Neuropharmacol. 1999, 38, 679-690). The P2 pell...


US Patent US8691840 (2014)


BindingDB Entry DOI: 10.7270/Q2M32TFR
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM125047
PNG
(US8772511, 4 | US9714242, 22)
Show SMILES COc1ccc(NC(=O)Nc2ccc3cc(sc3c2)C(=O)N[C@H]2CN3CCC2CC3)cc1
Show InChI InChI=1/C24H26N4O3S/c1-31-19-6-4-17(5-7-19)25-24(30)26-18-3-2-16-12-22(32-21(16)13-18)23(29)27-20-14-28-10-8-15(20)9-11-28/h2-7,12-13,15,20H,8-11,14H2,1H3,(H,27,29)(H2,25,26,30)/t20-/s2
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<1n/an/an/an/an/an/a7.4n/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
The [3H]-methyllycaconitine binding assay is a modification of the method described by Davies et al. in Neuropharmacol, 1999, 38, 679-690.Rat brain t...


US Patent US9714242 (2017)


Article DOI: 10.1021/jm960441m
BindingDB Entry DOI: 10.7270/Q2M61N83
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM165925
PNG
(US10214524, Example 20 | US9067931, 20)
Show SMILES OCc1ccc(cc1)-c1cccc2cc(sc12)C(=O)N[C@H]1CN2CCC1CC2
Show InChI InChI=1/C23H24N2O2S/c26-14-15-4-6-16(7-5-15)19-3-1-2-18-12-21(28-22(18)19)23(27)24-20-13-25-10-8-17(20)9-11-25/h1-7,12,17,20,26H,8-11,13-14H2,(H,24,27)/t20-/s2
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1.60n/an/an/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Rat brain tissue (hippocampus or whole brain) is homogenized in homogenization buffer (10% w/v, 0.32 M sucrose, 1 mM EDTA, 0.1 mM phenylmethylsulphon...


US Patent US10214524 (2019)


Article DOI: 10.1021/jm061329j
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM165925
PNG
(US10214524, Example 20 | US9067931, 20)
Show SMILES OCc1ccc(cc1)-c1cccc2cc(sc12)C(=O)N[C@H]1CN2CCC1CC2
Show InChI InChI=1/C23H24N2O2S/c26-14-15-4-6-16(7-5-15)19-3-1-2-18-12-21(28-22(18)19)23(27)24-20-13-25-10-8-17(20)9-11-25/h1-7,12,17,20,26H,8-11,13-14H2,(H,24,27)/t20-/s2
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1.60 -11.1n/an/an/an/an/a7.44



Bayer Intellectual Property GmbH

US Patent


Assay Description
The [3H]-methyllycaconitine binding assay is a modification of the method described by Davies et al. in Neuropharmacol. 1999, 38, 679-690.Rat brain t...


US Patent US9067931 (2015)


BindingDB Entry DOI: 10.7270/Q2M907F1
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM119802
PNG
(US8691840, 2)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1ccc(NC(=O)[C@H]2CN3CCC2CC3)cc1
Show InChI InChI=1/C21H25N3O3S/c1-28(26,27)23-19-8-4-16(5-9-19)15-2-6-18(7-3-15)22-21(25)20-14-24-12-10-17(20)11-13-24/h2-9,17,20,23H,10-14H2,1H3,(H,22,25)/t20-/s2
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2 -10.9n/an/an/an/an/a7.40



Bayer Intellectual Property GmbH

US Patent


Assay Description
The [3H]-methyllycaconitine binding assay is a modification of the method described by Davies et al. (Neuropharmacol. 1999, 38, 679-690). The P2 pell...


US Patent US8691840 (2014)


BindingDB Entry DOI: 10.7270/Q2M32TFR
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))
BDBM139032
PNG
(US8884017, 68)
Show SMILES Nc1cccc2cc(sc12)C(=O)N[C@H]1CN2CCC1CC2
Show InChI InChI=1/C16H19N3OS/c17-12-3-1-2-11-8-14(21-15(11)12)16(20)18-13-9-19-6-4-10(13)5-7-19/h1-3,8,10,13H,4-7,9,17H2,(H,18,20)/t13-/s2
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2 -11.0n/an/an/an/an/a7.44



Bayer Intellectual Property GmbH

US Patent


Assay Description
The [3H]-methyllycaconitine binding assay is a modification of the method described by Davies et al. in Neuropharmacol. 1999, 38, 679-690.Rat brain t...


US Patent US8884017 (2014)


BindingDB Entry DOI: 10.7270/Q2MK6BK3
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM125047
PNG
(US8772511, 4 | US9714242, 22)
Show SMILES COc1ccc(NC(=O)Nc2ccc3cc(sc3c2)C(=O)N[C@H]2CN3CCC2CC3)cc1
Show InChI InChI=1/C24H26N4O3S/c1-31-19-6-4-17(5-7-19)25-24(30)26-18-3-2-16-12-22(32-21(16)13-18)23(29)27-20-14-28-10-8-15(20)9-11-28/h2-7,12-13,15,20H,8-11,14H2,1H3,(H,27,29)(H2,25,26,30)/t20-/s2
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2.10n/an/an/an/an/an/a7.4n/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
The [3H]-methyllycaconitine binding assay is a modification of the method described by Davies et al. in Neuropharmacol, 1999, 38, 679-690.Rat brain t...


US Patent US9714242 (2017)


Article DOI: 10.1021/jm960441m
BindingDB Entry DOI: 10.7270/Q2M61N83
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM125047
PNG
(US8772511, 4 | US9714242, 22)
Show SMILES COc1ccc(NC(=O)Nc2ccc3cc(sc3c2)C(=O)N[C@H]2CN3CCC2CC3)cc1
Show InChI InChI=1/C24H26N4O3S/c1-31-19-6-4-17(5-7-19)25-24(30)26-18-3-2-16-12-22(32-21(16)13-18)23(29)27-20-14-28-10-8-15(20)9-11-28/h2-7,12-13,15,20H,8-11,14H2,1H3,(H,27,29)(H2,25,26,30)/t20-/s2
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2.10 -11.0n/an/an/an/an/a7.44



Bayer Intellectual Property GmbH

US Patent


Assay Description
Rat brain tissue (hippocampus or whole brain) is homogenized in aqueous homogenization buffer (10% w/v, 0.32 M sucrose, 1 mM EDTA, 0.1 mM phenylmethy...


US Patent US8772511 (2014)


BindingDB Entry DOI: 10.7270/Q2GQ6WF2
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))
BDBM139033
PNG
(US8884017, 73)
Show SMILES Nc1ccc2cc(sc2c1)C(=O)N[C@H]1CN2CCC1CC2
Show InChI InChI=1/C16H19N3OS/c17-12-2-1-11-7-15(21-14(11)8-12)16(20)18-13-9-19-5-3-10(13)4-6-19/h1-2,7-8,10,13H,3-6,9,17H2,(H,18,20)/t13-/s2
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2.80 -10.8n/an/an/an/an/a7.44



Bayer Intellectual Property GmbH

US Patent


Assay Description
The [3H]-methyllycaconitine binding assay is a modification of the method described by Davies et al. in Neuropharmacol. 1999, 38, 679-690.Rat brain t...


US Patent US8884017 (2014)


BindingDB Entry DOI: 10.7270/Q2MK6BK3
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM165935
PNG
(US10214524, Example 154 | US9067931, 154)
Show SMILES O=C(N[C@H]1CN2CCC1CC2)c1cc2cccc(-c3cccc(c3)C(=O)NC3CC3)c2o1
Show InChI InChI=1/C26H27N3O3/c30-25(27-20-7-8-20)19-5-1-3-17(13-19)21-6-2-4-18-14-23(32-24(18)21)26(31)28-22-15-29-11-9-16(22)10-12-29/h1-6,13-14,16,20,22H,7-12,15H2,(H,27,30)(H,28,31)/t22-/s2
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3n/an/an/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Rat brain tissue (hippocampus or whole brain) is homogenized in homogenization buffer (10% w/v, 0.32 M sucrose, 1 mM EDTA, 0.1 mM phenylmethylsulphon...


US Patent US10214524 (2019)


Article DOI: 10.1021/jm061329j
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM165935
PNG
(US10214524, Example 154 | US9067931, 154)
Show SMILES O=C(N[C@H]1CN2CCC1CC2)c1cc2cccc(-c3cccc(c3)C(=O)NC3CC3)c2o1
Show InChI InChI=1/C26H27N3O3/c30-25(27-20-7-8-20)19-5-1-3-17(13-19)21-6-2-4-18-14-23(32-24(18)21)26(31)28-22-15-29-11-9-16(22)10-12-29/h1-6,13-14,16,20,22H,7-12,15H2,(H,27,30)(H,28,31)/t22-/s2
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3 -10.8n/an/an/an/an/a7.44



Bayer Intellectual Property GmbH

US Patent


Assay Description
The [3H]-methyllycaconitine binding assay is a modification of the method described by Davies et al. in Neuropharmacol. 1999, 38, 679-690.Rat brain t...


US Patent US9067931 (2015)


BindingDB Entry DOI: 10.7270/Q2M907F1
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))
BDBM139027
PNG
(US8884017, 58)
Show SMILES Fc1cccc2cc(sc12)C(=O)N[C@H]1CN2CCC1CC2
Show InChI InChI=1/C16H17FN2OS/c17-12-3-1-2-11-8-14(21-15(11)12)16(20)18-13-9-19-6-4-10(13)5-7-19/h1-3,8,10,13H,4-7,9H2,(H,18,20)/t13-/s2
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3.10 -10.8n/an/an/an/an/a7.44



Bayer Intellectual Property GmbH

US Patent


Assay Description
The [3H]-methyllycaconitine binding assay is a modification of the method described by Davies et al. in Neuropharmacol. 1999, 38, 679-690.Rat brain t...


US Patent US8884017 (2014)


BindingDB Entry DOI: 10.7270/Q2MK6BK3
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM165928
PNG
(US10214524, Example 76 | US9067931, 76)
Show SMILES CNC(=O)NCc1ccccc1-c1cccc2cc(sc12)C(=O)N[C@H]1CN2CCC1CC2
Show InChI InChI=1/C25H28N4O2S/c1-26-25(31)27-14-18-5-2-3-7-19(18)20-8-4-6-17-13-22(32-23(17)20)24(30)28-21-15-29-11-9-16(21)10-12-29/h2-8,13,16,21H,9-12,14-15H2,1H3,(H,28,30)(H2,26,27,31)/t21-/s2
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US Patent
3.30n/an/an/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Rat brain tissue (hippocampus or whole brain) is homogenized in homogenization buffer (10% w/v, 0.32 M sucrose, 1 mM EDTA, 0.1 mM phenylmethylsulphon...


US Patent US10214524 (2019)


Article DOI: 10.1021/jm061329j
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM165928
PNG
(US10214524, Example 76 | US9067931, 76)
Show SMILES CNC(=O)NCc1ccccc1-c1cccc2cc(sc12)C(=O)N[C@H]1CN2CCC1CC2
Show InChI InChI=1/C25H28N4O2S/c1-26-25(31)27-14-18-5-2-3-7-19(18)20-8-4-6-17-13-22(32-23(17)20)24(30)28-21-15-29-11-9-16(21)10-12-29/h2-8,13,16,21H,9-12,14-15H2,1H3,(H,28,30)(H2,26,27,31)/t21-/s2
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3.30 -10.7n/an/an/an/an/a7.44



Bayer Intellectual Property GmbH

US Patent


Assay Description
The [3H]-methyllycaconitine binding assay is a modification of the method described by Davies et al. in Neuropharmacol. 1999, 38, 679-690.Rat brain t...


US Patent US9067931 (2015)


BindingDB Entry DOI: 10.7270/Q2M907F1
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))
BDBM139020
PNG
(US8884017, 35)
Show SMILES Nc1ccc2cc(oc2c1)C(=O)N[C@H]1CN2CCC1CC2
Show InChI InChI=1/C16H19N3O2/c17-12-2-1-11-7-15(21-14(11)8-12)16(20)18-13-9-19-5-3-10(13)4-6-19/h1-2,7-8,10,13H,3-6,9,17H2,(H,18,20)/t13-/s2
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3.70 -10.7n/an/an/an/an/a7.44



Bayer Intellectual Property GmbH

US Patent


Assay Description
The [3H]-methyllycaconitine binding assay is a modification of the method described by Davies et al. in Neuropharmacol. 1999, 38, 679-690.Rat brain t...


US Patent US8884017 (2014)


BindingDB Entry DOI: 10.7270/Q2MK6BK3
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))
BDBM139026
PNG
(US8884017, 51)
Show SMILES O=C(N[C@H]1CN2CCC1CC2)c1cc2ccccc2s1
Show InChI InChI=1/C16H18N2OS/c19-16(15-9-12-3-1-2-4-14(12)20-15)17-13-10-18-7-5-11(13)6-8-18/h1-4,9,11,13H,5-8,10H2,(H,17,19)/t13-/s2
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3.90 -10.7n/an/an/an/an/a7.44



Bayer Intellectual Property GmbH

US Patent


Assay Description
The [3H]-methyllycaconitine binding assay is a modification of the method described by Davies et al. in Neuropharmacol. 1999, 38, 679-690.Rat brain t...


US Patent US8884017 (2014)


BindingDB Entry DOI: 10.7270/Q2MK6BK3
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM125052
PNG
(US8772511, 21 | US9714242, 21)
Show SMILES O=C(Nc1ccccc1)Nc1cccc2cc(sc12)C(=O)N[C@H]1CN2CCC1CC2
Show InChI InChI=1/C23H24N4O2S/c28-22(25-19-14-27-11-9-15(19)10-12-27)20-13-16-5-4-8-18(21(16)30-20)26-23(29)24-17-6-2-1-3-7-17/h1-8,13,15,19H,9-12,14H2,(H,25,28)(H2,24,26,29)/t19-/s2
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US Patent
4.30 -10.6n/an/an/an/an/a7.44



Bayer Intellectual Property GmbH

US Patent


Assay Description
Rat brain tissue (hippocampus or whole brain) is homogenized in aqueous homogenization buffer (10% w/v, 0.32 M sucrose, 1 mM EDTA, 0.1 mM phenylmethy...


US Patent US8772511 (2014)


BindingDB Entry DOI: 10.7270/Q2GQ6WF2
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM125051
PNG
(US8772511, 16 | US9714242, 16)
Show SMILES COc1cccc(NC(=O)Nc2ccc3cc(sc3c2)C(=O)N[C@H]2CN3CCC2CC3)c1
Show InChI InChI=1/C24H26N4O3S/c1-31-19-4-2-3-17(12-19)25-24(30)26-18-6-5-16-11-22(32-21(16)13-18)23(29)27-20-14-28-9-7-15(20)8-10-28/h2-6,11-13,15,20H,7-10,14H2,1H3,(H,27,29)(H2,25,26,30)/t20-/s2
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US Patent
4.30n/an/an/an/an/an/a7.4n/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
The [3H]-methyllycaconitine binding assay is a modification of the method described by Davies et al. in Neuropharmacol, 1999, 38, 679-690.Rat brain t...


US Patent US9714242 (2017)


Article DOI: 10.1021/jm960441m
BindingDB Entry DOI: 10.7270/Q2M61N83
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))
BDBM139035
PNG
(US8884017, 76)
Show SMILES COc1cccc2cc(sc12)C(=O)N[C@H]1CN2CCC1CC2
Show InChI InChI=1/C17H20N2O2S/c1-21-14-4-2-3-12-9-15(22-16(12)14)17(20)18-13-10-19-7-5-11(13)6-8-19/h2-4,9,11,13H,5-8,10H2,1H3,(H,18,20)/t13-/s2
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6.70 -10.4n/an/an/an/an/a7.44



Bayer Intellectual Property GmbH

US Patent


Assay Description
The [3H]-methyllycaconitine binding assay is a modification of the method described by Davies et al. in Neuropharmacol. 1999, 38, 679-690.Rat brain t...


US Patent US8884017 (2014)


BindingDB Entry DOI: 10.7270/Q2MK6BK3
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM125049
PNG
(US8772511, 6 | US9714242, 6)
Show SMILES O=C(Nc1cccc(c1)C#N)Nc1ccc2cc(sc2c1)C(=O)N[C@H]1CN2CCC1CC2
Show InChI InChI=1/C24H23N5O2S/c25-13-15-2-1-3-18(10-15)26-24(31)27-19-5-4-17-11-22(32-21(17)12-19)23(30)28-20-14-29-8-6-16(20)7-9-29/h1-5,10-12,16,20H,6-9,14H2,(H,28,30)(H2,26,27,31)/t20-/s2
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7.90 -10.3n/an/an/an/an/a7.44



Bayer Intellectual Property GmbH

US Patent


Assay Description
Rat brain tissue (hippocampus or whole brain) is homogenized in aqueous homogenization buffer (10% w/v, 0.32 M sucrose, 1 mM EDTA, 0.1 mM phenylmethy...


US Patent US8772511 (2014)


BindingDB Entry DOI: 10.7270/Q2GQ6WF2
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM125049
PNG
(US8772511, 6 | US9714242, 6)
Show SMILES O=C(Nc1cccc(c1)C#N)Nc1ccc2cc(sc2c1)C(=O)N[C@H]1CN2CCC1CC2
Show InChI InChI=1/C24H23N5O2S/c25-13-15-2-1-3-18(10-15)26-24(31)27-19-5-4-17-11-22(32-21(17)12-19)23(30)28-20-14-29-8-6-16(20)7-9-29/h1-5,10-12,16,20H,6-9,14H2,(H,28,30)(H2,26,27,31)/t20-/s2
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7.90n/an/an/an/an/an/a7.4n/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
The [3H]-methyllycaconitine binding assay is a modification of the method described by Davies et al. in Neuropharmacol, 1999, 38, 679-690.Rat brain t...


US Patent US9714242 (2017)


Article DOI: 10.1021/jm960441m
BindingDB Entry DOI: 10.7270/Q2M61N83
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM165937
PNG
(US10214524, Example 175 | US9067931, 175)
Show SMILES CNC(=O)NCc1ccccc1-c1cccc2cc(oc12)C(=O)N[C@H]1CN2CCC1CC2
Show InChI InChI=1/C25H28N4O3/c1-26-25(31)27-14-18-5-2-3-7-19(18)20-8-4-6-17-13-22(32-23(17)20)24(30)28-21-15-29-11-9-16(21)10-12-29/h2-8,13,16,21H,9-12,14-15H2,1H3,(H,28,30)(H2,26,27,31)/t21-/s2
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8.30n/an/an/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Rat brain tissue (hippocampus or whole brain) is homogenized in homogenization buffer (10% w/v, 0.32 M sucrose, 1 mM EDTA, 0.1 mM phenylmethylsulphon...


US Patent US10214524 (2019)


Article DOI: 10.1021/jm061329j
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM165937
PNG
(US10214524, Example 175 | US9067931, 175)
Show SMILES CNC(=O)NCc1ccccc1-c1cccc2cc(oc12)C(=O)N[C@H]1CN2CCC1CC2
Show InChI InChI=1/C25H28N4O3/c1-26-25(31)27-14-18-5-2-3-7-19(18)20-8-4-6-17-13-22(32-23(17)20)24(30)28-21-15-29-11-9-16(21)10-12-29/h2-8,13,16,21H,9-12,14-15H2,1H3,(H,28,30)(H2,26,27,31)/t21-/s2
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8.30 -10.2n/an/an/an/an/a7.44



Bayer Intellectual Property GmbH

US Patent


Assay Description
The [3H]-methyllycaconitine binding assay is a modification of the method described by Davies et al. in Neuropharmacol. 1999, 38, 679-690.Rat brain t...


US Patent US9067931 (2015)


BindingDB Entry DOI: 10.7270/Q2M907F1
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM165936
PNG
(US10214524, Example 163 | US9067931, 163)
Show SMILES CN1CCN(CC1)C(=O)c1cccc(c1)-c1cccc2cc(oc12)C(=O)N[C@H]1CN2CCC1CC2
Show InChI InChI=1/C28H32N4O3/c1-30-12-14-32(15-13-30)28(34)22-6-2-4-20(16-22)23-7-3-5-21-17-25(35-26(21)23)27(33)29-24-18-31-10-8-19(24)9-11-31/h2-7,16-17,19,24H,8-15,18H2,1H3,(H,29,33)/t24-/s2
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14 -9.95n/an/an/an/an/a7.44



Bayer Intellectual Property GmbH

US Patent


Assay Description
The [3H]-methyllycaconitine binding assay is a modification of the method described by Davies et al. in Neuropharmacol. 1999, 38, 679-690.Rat brain t...


US Patent US9067931 (2015)


BindingDB Entry DOI: 10.7270/Q2M907F1
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM165936
PNG
(US10214524, Example 163 | US9067931, 163)
Show SMILES CN1CCN(CC1)C(=O)c1cccc(c1)-c1cccc2cc(oc12)C(=O)N[C@H]1CN2CCC1CC2
Show InChI InChI=1/C28H32N4O3/c1-30-12-14-32(15-13-30)28(34)22-6-2-4-20(16-22)23-7-3-5-21-17-25(35-26(21)23)27(33)29-24-18-31-10-8-19(24)9-11-31/h2-7,16-17,19,24H,8-15,18H2,1H3,(H,29,33)/t24-/s2
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14n/an/an/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Rat brain tissue (hippocampus or whole brain) is homogenized in homogenization buffer (10% w/v, 0.32 M sucrose, 1 mM EDTA, 0.1 mM phenylmethylsulphon...


US Patent US10214524 (2019)


Article DOI: 10.1021/jm061329j
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM165929
PNG
(US10214524, Example 90 | US9067931, 90)
Show SMILES O=C(N[C@H]1CN2CCC1CC2)c1cc2cccc(-c3ccc(cc3)N3CCOCC3=O)c2o1
Show InChI InChI=1/C26H27N3O4/c30-24-16-32-13-12-29(24)20-6-4-17(5-7-20)21-3-1-2-19-14-23(33-25(19)21)26(31)27-22-15-28-10-8-18(22)9-11-28/h1-7,14,18,22H,8-13,15-16H2,(H,27,31)/t22-/s2
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14 -9.95n/an/an/an/an/a7.44



Bayer Intellectual Property GmbH

US Patent


Assay Description
The [3H]-methyllycaconitine binding assay is a modification of the method described by Davies et al. in Neuropharmacol. 1999, 38, 679-690.Rat brain t...


US Patent US9067931 (2015)


BindingDB Entry DOI: 10.7270/Q2M907F1
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM165929
PNG
(US10214524, Example 90 | US9067931, 90)
Show SMILES O=C(N[C@H]1CN2CCC1CC2)c1cc2cccc(-c3ccc(cc3)N3CCOCC3=O)c2o1
Show InChI InChI=1/C26H27N3O4/c30-24-16-32-13-12-29(24)20-6-4-17(5-7-20)21-3-1-2-19-14-23(33-25(19)21)26(31)27-22-15-28-10-8-18(22)9-11-28/h1-7,14,18,22H,8-13,15-16H2,(H,27,31)/t22-/s2
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14n/an/an/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Rat brain tissue (hippocampus or whole brain) is homogenized in homogenization buffer (10% w/v, 0.32 M sucrose, 1 mM EDTA, 0.1 mM phenylmethylsulphon...


US Patent US10214524 (2019)


Article DOI: 10.1021/jm061329j
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM125052
PNG
(US8772511, 21 | US9714242, 21)
Show SMILES O=C(Nc1ccccc1)Nc1cccc2cc(sc12)C(=O)N[C@H]1CN2CCC1CC2
Show InChI InChI=1/C23H24N4O2S/c28-22(25-19-14-27-11-9-15(19)10-12-27)20-13-16-5-4-8-18(21(16)30-20)26-23(29)24-17-6-2-1-3-7-17/h1-8,13,15,19H,9-12,14H2,(H,25,28)(H2,24,26,29)/t19-/s2
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15n/an/an/an/an/an/a7.4n/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
The [3H]-methyllycaconitine binding assay is a modification of the method described by Davies et al. in Neuropharmacol, 1999, 38, 679-690.Rat brain t...


US Patent US9714242 (2017)


Article DOI: 10.1021/jm960441m
BindingDB Entry DOI: 10.7270/Q2M61N83
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM125051
PNG
(US8772511, 16 | US9714242, 16)
Show SMILES COc1cccc(NC(=O)Nc2ccc3cc(sc3c2)C(=O)N[C@H]2CN3CCC2CC3)c1
Show InChI InChI=1/C24H26N4O3S/c1-31-19-4-2-3-17(12-19)25-24(30)26-18-6-5-16-11-22(32-21(16)13-18)23(29)27-20-14-28-9-7-15(20)8-10-28/h2-6,11-13,15,20H,7-10,14H2,1H3,(H,27,29)(H2,25,26,30)/t20-/s2
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15 -9.91n/an/an/an/an/a7.44



Bayer Intellectual Property GmbH

US Patent


Assay Description
Rat brain tissue (hippocampus or whole brain) is homogenized in aqueous homogenization buffer (10% w/v, 0.32 M sucrose, 1 mM EDTA, 0.1 mM phenylmethy...


US Patent US8772511 (2014)


BindingDB Entry DOI: 10.7270/Q2GQ6WF2
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM119805
PNG
(US8691840, 11)
Show SMILES O=C(NC1CCCC1)Nc1ccc(cc1)-c1ccc(NC(=O)[C@H]2CN3CCC2CC3)cc1
Show InChI InChI=1/C26H32N4O2/c31-25(24-17-30-15-13-20(24)14-16-30)27-22-9-5-18(6-10-22)19-7-11-23(12-8-19)29-26(32)28-21-3-1-2-4-21/h5-12,20-21,24H,1-4,13-17H2,(H,27,31)(H2,28,29,32)/t24-/s2
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16 -9.74n/an/an/an/an/a7.40



Bayer Intellectual Property GmbH

US Patent


Assay Description
The [3H]-methyllycaconitine binding assay is a modification of the method described by Davies et al. (Neuropharmacol. 1999, 38, 679-690). The P2 pell...


US Patent US8691840 (2014)


BindingDB Entry DOI: 10.7270/Q2M32TFR
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM165931
PNG
(US10214524, Example 116 | US9067931, 116)
Show SMILES O=C(Nc1cccc(c1)-c1cccc2cc(oc12)C(=O)N[C@H]1CN2CCC1CC2)C1CC1
Show InChI InChI=1/C26H27N3O3/c30-25(17-7-8-17)27-20-5-1-3-18(13-20)21-6-2-4-19-14-23(32-24(19)21)26(31)28-22-15-29-11-9-16(22)10-12-29/h1-6,13-14,16-17,22H,7-12,15H2,(H,27,30)(H,28,31)/t22-/s2
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17n/an/an/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Rat brain tissue (hippocampus or whole brain) is homogenized in homogenization buffer (10% w/v, 0.32 M sucrose, 1 mM EDTA, 0.1 mM phenylmethylsulphon...


US Patent US10214524 (2019)


Article DOI: 10.1021/jm061329j
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM165930
PNG
(US10214524, Example 108 | US9067931, 108)
Show SMILES CCNC(=O)Nc1cccc(c1)-c1cccc2cc(oc12)C(=O)N[C@H]1CN2CCC1CC2
Show InChI InChI=1/C25H28N4O3/c1-2-26-25(31)27-19-7-3-5-17(13-19)20-8-4-6-18-14-22(32-23(18)20)24(30)28-21-15-29-11-9-16(21)10-12-29/h3-8,13-14,16,21H,2,9-12,15H2,1H3,(H,28,30)(H2,26,27,31)/t21-/s2
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17 -9.85n/an/an/an/an/a7.44



Bayer Intellectual Property GmbH

US Patent


Assay Description
The [3H]-methyllycaconitine binding assay is a modification of the method described by Davies et al. in Neuropharmacol. 1999, 38, 679-690.Rat brain t...


US Patent US9067931 (2015)


BindingDB Entry DOI: 10.7270/Q2M907F1
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM165930
PNG
(US10214524, Example 108 | US9067931, 108)
Show SMILES CCNC(=O)Nc1cccc(c1)-c1cccc2cc(oc12)C(=O)N[C@H]1CN2CCC1CC2
Show InChI InChI=1/C25H28N4O3/c1-2-26-25(31)27-19-7-3-5-17(13-19)20-8-4-6-18-14-22(32-23(18)20)24(30)28-21-15-29-11-9-16(21)10-12-29/h3-8,13-14,16,21H,2,9-12,15H2,1H3,(H,28,30)(H2,26,27,31)/t21-/s2
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17n/an/an/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Rat brain tissue (hippocampus or whole brain) is homogenized in homogenization buffer (10% w/v, 0.32 M sucrose, 1 mM EDTA, 0.1 mM phenylmethylsulphon...


US Patent US10214524 (2019)


Article DOI: 10.1021/jm061329j
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM165931
PNG
(US10214524, Example 116 | US9067931, 116)
Show SMILES O=C(Nc1cccc(c1)-c1cccc2cc(oc12)C(=O)N[C@H]1CN2CCC1CC2)C1CC1
Show InChI InChI=1/C26H27N3O3/c30-25(17-7-8-17)27-20-5-1-3-18(13-20)21-6-2-4-19-14-23(32-24(19)21)26(31)28-22-15-29-11-9-16(22)10-12-29/h1-6,13-14,16-17,22H,7-12,15H2,(H,27,30)(H,28,31)/t22-/s2
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17 -9.85n/an/an/an/an/a7.44



Bayer Intellectual Property GmbH

US Patent


Assay Description
The [3H]-methyllycaconitine binding assay is a modification of the method described by Davies et al. in Neuropharmacol. 1999, 38, 679-690.Rat brain t...


US Patent US9067931 (2015)


BindingDB Entry DOI: 10.7270/Q2M907F1
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM165923
PNG
(US10214524, Example 17 | US9067931, 17)
Show SMILES COc1cccc(c1)-c1cccc2cc(sc12)C(=O)N[C@H]1CN2CCC1CC2
Show InChI InChI=1/C23H24N2O2S/c1-27-18-6-2-4-16(12-18)19-7-3-5-17-13-21(28-22(17)19)23(26)24-20-14-25-10-8-15(20)9-11-25/h2-7,12-13,15,20H,8-11,14H2,1H3,(H,24,26)/t20-/s2
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17 -9.85n/an/an/an/an/a7.44



Bayer Intellectual Property GmbH

US Patent


Assay Description
The [3H]-methyllycaconitine binding assay is a modification of the method described by Davies et al. in Neuropharmacol. 1999, 38, 679-690.Rat brain t...


US Patent US9067931 (2015)


BindingDB Entry DOI: 10.7270/Q2M907F1
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM165923
PNG
(US10214524, Example 17 | US9067931, 17)
Show SMILES COc1cccc(c1)-c1cccc2cc(sc12)C(=O)N[C@H]1CN2CCC1CC2
Show InChI InChI=1/C23H24N2O2S/c1-27-18-6-2-4-16(12-18)19-7-3-5-17-13-21(28-22(17)19)23(26)24-20-14-25-10-8-15(20)9-11-25/h2-7,12-13,15,20H,8-11,14H2,1H3,(H,24,26)/t20-/s2
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17n/an/an/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Rat brain tissue (hippocampus or whole brain) is homogenized in homogenization buffer (10% w/v, 0.32 M sucrose, 1 mM EDTA, 0.1 mM phenylmethylsulphon...


US Patent US10214524 (2019)


Article DOI: 10.1021/jm061329j
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))
BDBM139030
PNG
(US8884017, 64)
Show SMILES FC(F)(F)c1cccc2cc(sc12)C(=O)N[C@H]1CN2CCC1CC2
Show InChI InChI=1/C17H17F3N2OS/c18-17(19,20)12-3-1-2-11-8-14(24-15(11)12)16(23)21-13-9-22-6-4-10(13)5-7-22/h1-3,8,10,13H,4-7,9H2,(H,21,23)/t13-/s2
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20 -9.76n/an/an/an/an/a7.44



Bayer Intellectual Property GmbH

US Patent


Assay Description
The [3H]-methyllycaconitine binding assay is a modification of the method described by Davies et al. in Neuropharmacol. 1999, 38, 679-690.Rat brain t...


US Patent US8884017 (2014)


BindingDB Entry DOI: 10.7270/Q2MK6BK3
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM165924
PNG
(US10214524, Example 19 | US9067931, 19)
Show SMILES O=C(N[C@H]1CN2CCC1CC2)c1cc2cccc(-c3ccc(cc3)N3CCOCC3)c2s1
Show InChI InChI=1/C26H29N3O2S/c30-26(27-23-17-28-10-8-19(23)9-11-28)24-16-20-2-1-3-22(25(20)32-24)18-4-6-21(7-5-18)29-12-14-31-15-13-29/h1-7,16,19,23H,8-15,17H2,(H,27,30)/t23-/s2
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20 -9.76n/an/an/an/an/a7.44



Bayer Intellectual Property GmbH

US Patent


Assay Description
The [3H]-methyllycaconitine binding assay is a modification of the method described by Davies et al. in Neuropharmacol. 1999, 38, 679-690.Rat brain t...


US Patent US9067931 (2015)


BindingDB Entry DOI: 10.7270/Q2M907F1
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))
BDBM139036
PNG
(US8884017, 77)
Show SMILES COc1cccc2cc(sc12)C(=O)N[C@@H]1CN2CCC1CC2
Show InChI InChI=1/C17H20N2O2S/c1-21-14-4-2-3-12-9-15(22-16(12)14)17(20)18-13-10-19-7-5-11(13)6-8-19/h2-4,9,11,13H,5-8,10H2,1H3,(H,18,20)/t13-/s2
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20 -9.76n/an/an/an/an/a7.44



Bayer Intellectual Property GmbH

US Patent


Assay Description
The [3H]-methyllycaconitine binding assay is a modification of the method described by Davies et al. in Neuropharmacol. 1999, 38, 679-690.Rat brain t...


US Patent US8884017 (2014)


BindingDB Entry DOI: 10.7270/Q2MK6BK3
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))
BDBM139028
PNG
(US8884017, 59)
Show SMILES Fc1cccc2cc(sc12)C(=O)N[C@@H]1CN2CCC1CC2
Show InChI InChI=1/C16H17FN2OS/c17-12-3-1-2-11-8-14(21-15(11)12)16(20)18-13-9-19-6-4-10(13)5-7-19/h1-3,8,10,13H,4-7,9H2,(H,18,20)/t13-/s2
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20 -9.76n/an/an/an/an/a7.44



Bayer Intellectual Property GmbH

US Patent


Assay Description
The [3H]-methyllycaconitine binding assay is a modification of the method described by Davies et al. in Neuropharmacol. 1999, 38, 679-690.Rat brain t...


US Patent US8884017 (2014)


BindingDB Entry DOI: 10.7270/Q2MK6BK3
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor


(Rattus norvegicus (Rat))
BDBM165924
PNG
(US10214524, Example 19 | US9067931, 19)
Show SMILES O=C(N[C@H]1CN2CCC1CC2)c1cc2cccc(-c3ccc(cc3)N3CCOCC3)c2s1
Show InChI InChI=1/C26H29N3O2S/c30-26(27-23-17-28-10-8-19(23)9-11-28)24-16-20-2-1-3-22(25(20)32-24)18-4-6-21(7-5-18)29-12-14-31-15-13-29/h1-7,16,19,23H,8-15,17H2,(H,27,30)/t23-/s2
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20n/an/an/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
Rat brain tissue (hippocampus or whole brain) is homogenized in homogenization buffer (10% w/v, 0.32 M sucrose, 1 mM EDTA, 0.1 mM phenylmethylsulphon...


US Patent US10214524 (2019)


Article DOI: 10.1021/jm061329j
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit


(Homo sapiens (Human))
BDBM139034
PNG
(US8884017, 74)
Show SMILES Fc1ccc2sc(cc2c1)C(=O)N[C@H]1CN2CCC1CC2
Show InChI InChI=1/C16H17FN2OS/c17-12-1-2-14-11(7-12)8-15(21-14)16(20)18-13-9-19-5-3-10(13)4-6-19/h1-2,7-8,10,13H,3-6,9H2,(H,18,20)/t13-/s2
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22 -9.70n/an/an/an/an/a7.44



Bayer Intellectual Property GmbH

US Patent


Assay Description
The [3H]-methyllycaconitine binding assay is a modification of the method described by Davies et al. in Neuropharmacol. 1999, 38, 679-690.Rat brain t...


US Patent US8884017 (2014)


BindingDB Entry DOI: 10.7270/Q2MK6BK3
More data for this
Ligand-Target Pair
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