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Compile Data Set for Download or QSAR

Found 99 hits from Bayer Yakuhin, Ltd   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM50344356
PNG
(CHEMBL1779676 | ethyl 3-(3-(7-hydroxynaphthalen-1-...)
Show SMILES CCOC(=O)c1cccc(NC(=O)Nc2cccc3ccc(O)cc23)c1
Show InChI InChI=1S/C20H18N2O4/c1-2-26-19(24)14-6-3-7-15(11-14)21-20(25)22-18-8-4-5-13-9-10-16(23)12-17(13)18/h3-12,23H,2H2,1H3,(H2,21,22,25)
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n/an/a 1.60n/an/an/an/an/an/a



Bayer Yakuhin, Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells co-expressing aequorin and CRE-luciferase reporter gene assessed as inhibition of capsaicin-i...


Bioorg Med Chem Lett 21: 3354-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.013
BindingDB Entry DOI: 10.7270/Q2NG4QXN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM50344356
PNG
(CHEMBL1779676 | ethyl 3-(3-(7-hydroxynaphthalen-1-...)
Show SMILES CCOC(=O)c1cccc(NC(=O)Nc2cccc3ccc(O)cc23)c1
Show InChI InChI=1S/C20H18N2O4/c1-2-26-19(24)14-6-3-7-15(11-14)21-20(25)22-18-8-4-5-13-9-10-16(23)12-17(13)18/h3-12,23H,2H2,1H3,(H2,21,22,25)
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n/an/a 1.70n/an/an/an/an/an/a



Bayer Yakuhin, Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV1 expressed in CHO cells co-expressing aequorin and CRE-luciferase reporter gene assessed as inhibition of capsaicin...


Bioorg Med Chem Lett 21: 3354-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.013
BindingDB Entry DOI: 10.7270/Q2NG4QXN
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM50344367
PNG
(1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(7-hydrox...)
Show SMILES Oc1ccc2cccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)c2c1
Show InChI InChI=1S/C18H12ClF3N2O2/c19-15-7-5-11(8-14(15)18(20,21)22)23-17(26)24-16-3-1-2-10-4-6-12(25)9-13(10)16/h1-9,25H,(H2,23,24,26)
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n/an/a 1.90n/an/an/an/an/an/a



Bayer Yakuhin, Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells co-expressing aequorin and CRE-luciferase reporter gene assessed as inhibition of capsaicin-i...


Bioorg Med Chem Lett 21: 3354-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.013
BindingDB Entry DOI: 10.7270/Q2NG4QXN
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM50344378
PNG
(1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2,3-dich...)
Show SMILES Oc1ccc2cc(Cl)c(Cl)c(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)c2c1
Show InChI InChI=1S/C18H10Cl3F3N2O2/c19-13-4-2-9(6-12(13)18(22,23)24)25-17(28)26-16-11-7-10(27)3-1-8(11)5-14(20)15(16)21/h1-7,27H,(H2,25,26,28)
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n/an/a 2.10n/an/an/an/an/an/a



Bayer Yakuhin, Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells co-expressing aequorin and CRE-luciferase reporter gene assessed as inhibition of capsaicin-i...


Bioorg Med Chem Lett 21: 3354-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.013
BindingDB Entry DOI: 10.7270/Q2NG4QXN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM50344367
PNG
(1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(7-hydrox...)
Show SMILES Oc1ccc2cccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)c2c1
Show InChI InChI=1S/C18H12ClF3N2O2/c19-15-7-5-11(8-14(15)18(20,21)22)23-17(26)24-16-3-1-2-10-4-6-12(25)9-13(10)16/h1-9,25H,(H2,23,24,26)
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n/an/a 2.20n/an/an/an/an/an/a



Bayer Yakuhin, Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV1 expressed in CHOluc9aeq cells assessed as inhibition of capsaicin-stimulated response by aequorin and CRE-lucifear...


Bioorg Med Chem Lett 22: 3408-11 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.108
BindingDB Entry DOI: 10.7270/Q2C24XF7
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM50344367
PNG
(1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(7-hydrox...)
Show SMILES Oc1ccc2cccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)c2c1
Show InChI InChI=1S/C18H12ClF3N2O2/c19-15-7-5-11(8-14(15)18(20,21)22)23-17(26)24-16-3-1-2-10-4-6-12(25)9-13(10)16/h1-9,25H,(H2,23,24,26)
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n/an/a 2.20n/an/an/an/an/an/a



Bayer Yakuhin, Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV1 expressed in CHO cells co-expressing aequorin and CRE-luciferase reporter gene assessed as inhibition of capsaicin...


Bioorg Med Chem Lett 21: 3354-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.013
BindingDB Entry DOI: 10.7270/Q2NG4QXN
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM50344348
PNG
(1-(3-chlorophenyl)-3-(7-hydroxynaphthalen-1-yl)ure...)
Show SMILES Oc1ccc2cccc(NC(=O)Nc3cccc(Cl)c3)c2c1
Show InChI InChI=1S/C17H13ClN2O2/c18-12-4-2-5-13(9-12)19-17(22)20-16-6-1-3-11-7-8-14(21)10-15(11)16/h1-10,21H,(H2,19,20,22)
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n/an/a 3.20n/an/an/an/an/an/a



Bayer Yakuhin, Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells co-expressing aequorin and CRE-luciferase reporter gene assessed as inhibition of capsaicin-i...


Bioorg Med Chem Lett 21: 3354-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.013
BindingDB Entry DOI: 10.7270/Q2NG4QXN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM50382237
PNG
(CHEMBL2024668)
Show SMILES OC1CCc2cccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)c2C1
Show InChI InChI=1S/C18H16ClF3N2O2/c19-15-7-5-11(8-14(15)18(20,21)22)23-17(26)24-16-3-1-2-10-4-6-12(25)9-13(10)16/h1-3,5,7-8,12,25H,4,6,9H2,(H2,23,24,26)
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n/an/a 3.30n/an/an/an/an/an/a



Bayer Yakuhin, Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV1 expressed in CHOluc9aeq cells assessed as inhibition of capsaicin-stimulated response by aequorin and CRE-lucifear...


Bioorg Med Chem Lett 22: 3408-11 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.108
BindingDB Entry DOI: 10.7270/Q2C24XF7
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM50344377
PNG
(1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2-chloro...)
Show SMILES Oc1ccc2ccc(Cl)c(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)c2c1
Show InChI InChI=1S/C18H11Cl2F3N2O2/c19-14-6-3-10(7-13(14)18(21,22)23)24-17(27)25-16-12-8-11(26)4-1-9(12)2-5-15(16)20/h1-8,26H,(H2,24,25,27)
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n/an/a 3.40n/an/an/an/an/an/a



Bayer Yakuhin, Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV1 expressed in CHO cells co-expressing aequorin and CRE-luciferase reporter gene assessed as inhibition of capsaicin...


Bioorg Med Chem Lett 21: 3354-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.013
BindingDB Entry DOI: 10.7270/Q2NG4QXN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM50344345
PNG
(1-(7-hydroxynaphthalen-1-yl)-3-(3-(trifluoromethyl...)
Show SMILES Oc1ccc2cccc(NC(=O)Nc3cccc(c3)C(F)(F)F)c2c1
Show InChI InChI=1S/C18H13F3N2O2/c19-18(20,21)12-4-2-5-13(9-12)22-17(25)23-16-6-1-3-11-7-8-14(24)10-15(11)16/h1-10,24H,(H2,22,23,25)
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n/an/a 3.5n/an/an/an/an/an/a



Bayer Yakuhin, Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV1 expressed in CHO cells co-expressing aequorin and CRE-luciferase reporter gene assessed as inhibition of capsaicin...


Bioorg Med Chem Lett 21: 3354-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.013
BindingDB Entry DOI: 10.7270/Q2NG4QXN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM50382237
PNG
(CHEMBL2024668)
Show SMILES OC1CCc2cccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)c2C1
Show InChI InChI=1S/C18H16ClF3N2O2/c19-15-7-5-11(8-14(15)18(20,21)22)23-17(26)24-16-3-1-2-10-4-6-12(25)9-13(10)16/h1-3,5,7-8,12,25H,4,6,9H2,(H2,23,24,26)
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n/an/a 3.80n/an/an/an/an/an/a



Bayer Yakuhin, Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV1 expressed in CHOluc9aeq cells assessed as inhibition of capsaicin-stimulated response by aequorin and CRE-lucifear...


Bioorg Med Chem Lett 22: 3408-11 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.108
BindingDB Entry DOI: 10.7270/Q2C24XF7
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM20412
PNG
(3-(7-hydroxynaphthalen-1-yl)-1-[3-(methylsulfanyl)...)
Show SMILES CSc1cccc(NC(=O)Nc2cccc3ccc(O)cc23)c1
Show InChI InChI=1S/C18H16N2O2S/c1-23-15-6-3-5-13(10-15)19-18(22)20-17-7-2-4-12-8-9-14(21)11-16(12)17/h2-11,21H,1H3,(H2,19,20,22)
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n/an/a 3.90n/an/an/an/an/an/a



Bayer Yakuhin, Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV1 expressed in CHO cells co-expressing aequorin and CRE-luciferase reporter gene assessed as inhibition of capsaicin...


Bioorg Med Chem Lett 21: 3354-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.013
BindingDB Entry DOI: 10.7270/Q2NG4QXN
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM50344377
PNG
(1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2-chloro...)
Show SMILES Oc1ccc2ccc(Cl)c(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)c2c1
Show InChI InChI=1S/C18H11Cl2F3N2O2/c19-14-6-3-10(7-13(14)18(21,22)23)24-17(27)25-16-12-8-11(26)4-1-9(12)2-5-15(16)20/h1-8,26H,(H2,24,25,27)
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n/an/a 4.5n/an/an/an/an/an/a



Bayer Yakuhin, Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells co-expressing aequorin and CRE-luciferase reporter gene assessed as inhibition of capsaicin-i...


Bioorg Med Chem Lett 21: 3354-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.013
BindingDB Entry DOI: 10.7270/Q2NG4QXN
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM50344345
PNG
(1-(7-hydroxynaphthalen-1-yl)-3-(3-(trifluoromethyl...)
Show SMILES Oc1ccc2cccc(NC(=O)Nc3cccc(c3)C(F)(F)F)c2c1
Show InChI InChI=1S/C18H13F3N2O2/c19-18(20,21)12-4-2-5-13(9-12)22-17(25)23-16-6-1-3-11-7-8-14(24)10-15(11)16/h1-10,24H,(H2,22,23,25)
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n/an/a 4.5n/an/an/an/an/an/a



Bayer Yakuhin, Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells co-expressing aequorin and CRE-luciferase reporter gene assessed as inhibition of capsaicin-i...


Bioorg Med Chem Lett 21: 3354-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.013
BindingDB Entry DOI: 10.7270/Q2NG4QXN
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM50344363
PNG
(1-(3,4-dichlorophenyl)-3-(7-hydroxynaphthalen-1-yl...)
Show SMILES Oc1ccc2cccc(NC(=O)Nc3ccc(Cl)c(Cl)c3)c2c1
Show InChI InChI=1S/C17H12Cl2N2O2/c18-14-7-5-11(8-15(14)19)20-17(23)21-16-3-1-2-10-4-6-12(22)9-13(10)16/h1-9,22H,(H2,20,21,23)
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n/an/a 4.5n/an/an/an/an/an/a



Bayer Yakuhin, Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells co-expressing aequorin and CRE-luciferase reporter gene assessed as inhibition of capsaicin-i...


Bioorg Med Chem Lett 21: 3354-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.013
BindingDB Entry DOI: 10.7270/Q2NG4QXN
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM50344346
PNG
(1-(7-hydroxynaphthalen-1-yl)-3-(4-(trifluoromethyl...)
Show SMILES Oc1ccc2cccc(NC(=O)Nc3ccc(cc3)C(F)(F)F)c2c1
Show InChI InChI=1S/C18H13F3N2O2/c19-18(20,21)12-5-7-13(8-6-12)22-17(25)23-16-3-1-2-11-4-9-14(24)10-15(11)16/h1-10,24H,(H2,22,23,25)
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n/an/a 4.90n/an/an/an/an/an/a



Bayer Yakuhin, Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells co-expressing aequorin and CRE-luciferase reporter gene assessed as inhibition of capsaicin-i...


Bioorg Med Chem Lett 21: 3354-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.013
BindingDB Entry DOI: 10.7270/Q2NG4QXN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM50344363
PNG
(1-(3,4-dichlorophenyl)-3-(7-hydroxynaphthalen-1-yl...)
Show SMILES Oc1ccc2cccc(NC(=O)Nc3ccc(Cl)c(Cl)c3)c2c1
Show InChI InChI=1S/C17H12Cl2N2O2/c18-14-7-5-11(8-15(14)19)20-17(23)21-16-3-1-2-10-4-6-12(22)9-13(10)16/h1-9,22H,(H2,20,21,23)
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Bayer Yakuhin, Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV1 expressed in CHO cells co-expressing aequorin and CRE-luciferase reporter gene assessed as inhibition of capsaicin...


Bioorg Med Chem Lett 21: 3354-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.013
BindingDB Entry DOI: 10.7270/Q2NG4QXN
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM50344372
PNG
(1-(3-bromo-2-chloro-7-hydroxynaphthalen-1-yl)-3-(4...)
Show SMILES Oc1ccc2cc(Br)c(Cl)c(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)c2c1
Show InChI InChI=1S/C18H10BrCl2F3N2O2/c19-13-5-8-1-3-10(27)7-11(8)16(15(13)21)26-17(28)25-9-2-4-14(20)12(6-9)18(22,23)24/h1-7,27H,(H2,25,26,28)
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Bayer Yakuhin, Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells co-expressing aequorin and CRE-luciferase reporter gene assessed as inhibition of capsaicin-i...


Bioorg Med Chem Lett 21: 3354-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.013
BindingDB Entry DOI: 10.7270/Q2NG4QXN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM50344346
PNG
(1-(7-hydroxynaphthalen-1-yl)-3-(4-(trifluoromethyl...)
Show SMILES Oc1ccc2cccc(NC(=O)Nc3ccc(cc3)C(F)(F)F)c2c1
Show InChI InChI=1S/C18H13F3N2O2/c19-18(20,21)12-5-7-13(8-6-12)22-17(25)23-16-3-1-2-11-4-9-14(24)10-15(11)16/h1-10,24H,(H2,22,23,25)
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n/an/a 5.40n/an/an/an/an/an/a



Bayer Yakuhin, Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV1 expressed in CHO cells co-expressing aequorin and CRE-luciferase reporter gene assessed as inhibition of capsaicin...


Bioorg Med Chem Lett 21: 3354-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.013
BindingDB Entry DOI: 10.7270/Q2NG4QXN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM50344355
PNG
(1-(3-bromophenyl)-3-(7-hydroxynaphthalen-1-yl)urea...)
Show SMILES Oc1ccc2cccc(NC(=O)Nc3cccc(Br)c3)c2c1
Show InChI InChI=1S/C17H13BrN2O2/c18-12-4-2-5-13(9-12)19-17(22)20-16-6-1-3-11-7-8-14(21)10-15(11)16/h1-10,21H,(H2,19,20,22)
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n/an/a 5.70n/an/an/an/an/an/a



Bayer Yakuhin, Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV1 expressed in CHO cells co-expressing aequorin and CRE-luciferase reporter gene assessed as inhibition of capsaicin...


Bioorg Med Chem Lett 21: 3354-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.013
BindingDB Entry DOI: 10.7270/Q2NG4QXN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM50344378
PNG
(1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2,3-dich...)
Show SMILES Oc1ccc2cc(Cl)c(Cl)c(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)c2c1
Show InChI InChI=1S/C18H10Cl3F3N2O2/c19-13-4-2-9(6-12(13)18(22,23)24)25-17(28)26-16-11-7-10(27)3-1-8(11)5-14(20)15(16)21/h1-7,27H,(H2,25,26,28)
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n/an/a 5.90n/an/an/an/an/an/a



Bayer Yakuhin, Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV1 expressed in CHO cells co-expressing aequorin and CRE-luciferase reporter gene assessed as inhibition of capsaicin...


Bioorg Med Chem Lett 21: 3354-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.013
BindingDB Entry DOI: 10.7270/Q2NG4QXN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM50344348
PNG
(1-(3-chlorophenyl)-3-(7-hydroxynaphthalen-1-yl)ure...)
Show SMILES Oc1ccc2cccc(NC(=O)Nc3cccc(Cl)c3)c2c1
Show InChI InChI=1S/C17H13ClN2O2/c18-12-4-2-5-13(9-12)19-17(22)20-16-6-1-3-11-7-8-14(21)10-15(11)16/h1-10,21H,(H2,19,20,22)
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n/an/a 6.10n/an/an/an/an/an/a



Bayer Yakuhin, Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV1 expressed in CHO cells co-expressing aequorin and CRE-luciferase reporter gene assessed as inhibition of capsaicin...


Bioorg Med Chem Lett 21: 3354-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.013
BindingDB Entry DOI: 10.7270/Q2NG4QXN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM50344372
PNG
(1-(3-bromo-2-chloro-7-hydroxynaphthalen-1-yl)-3-(4...)
Show SMILES Oc1ccc2cc(Br)c(Cl)c(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)c2c1
Show InChI InChI=1S/C18H10BrCl2F3N2O2/c19-13-5-8-1-3-10(27)7-11(8)16(15(13)21)26-17(28)25-9-2-4-14(20)12(6-9)18(22,23)24/h1-7,27H,(H2,25,26,28)
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n/an/a 6.80n/an/an/an/an/an/a



Bayer Yakuhin, Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV1 expressed in CHO cells co-expressing aequorin and CRE-luciferase reporter gene assessed as inhibition of capsaicin...


Bioorg Med Chem Lett 21: 3354-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.013
BindingDB Entry DOI: 10.7270/Q2NG4QXN
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM20412
PNG
(3-(7-hydroxynaphthalen-1-yl)-1-[3-(methylsulfanyl)...)
Show SMILES CSc1cccc(NC(=O)Nc2cccc3ccc(O)cc23)c1
Show InChI InChI=1S/C18H16N2O2S/c1-23-15-6-3-5-13(10-15)19-18(22)20-17-7-2-4-12-8-9-14(21)11-16(12)17/h2-11,21H,1H3,(H2,19,20,22)
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n/an/a 7.10n/an/an/an/an/an/a



Bayer Yakuhin, Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells co-expressing aequorin and CRE-luciferase reporter gene assessed as inhibition of capsaicin-i...


Bioorg Med Chem Lett 21: 3354-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.013
BindingDB Entry DOI: 10.7270/Q2NG4QXN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM50344353
PNG
(1-(7-hydroxynaphthalen-1-yl)-3-(3-nitrophenyl)urea...)
Show SMILES Oc1ccc2cccc(NC(=O)Nc3cccc(c3)[N+]([O-])=O)c2c1
Show InChI InChI=1S/C17H13N3O4/c21-14-8-7-11-3-1-6-16(15(11)10-14)19-17(22)18-12-4-2-5-13(9-12)20(23)24/h1-10,21H,(H2,18,19,22)
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n/an/a 7.5n/an/an/an/an/an/a



Bayer Yakuhin, Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV1 expressed in CHO cells co-expressing aequorin and CRE-luciferase reporter gene assessed as inhibition of capsaicin...


Bioorg Med Chem Lett 21: 3354-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.013
BindingDB Entry DOI: 10.7270/Q2NG4QXN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM50344373
PNG
(1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2,3-dibr...)
Show SMILES Oc1ccc2cc(Br)c(Br)c(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)c2c1
Show InChI InChI=1S/C18H10Br2ClF3N2O2/c19-13-5-8-1-3-10(27)7-11(8)16(15(13)20)26-17(28)25-9-2-4-14(21)12(6-9)18(22,23)24/h1-7,27H,(H2,25,26,28)
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n/an/a 7.5n/an/an/an/an/an/a



Bayer Yakuhin, Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV1 expressed in CHO cells co-expressing aequorin and CRE-luciferase reporter gene assessed as inhibition of capsaicin...


Bioorg Med Chem Lett 21: 3354-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.013
BindingDB Entry DOI: 10.7270/Q2NG4QXN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM50344352
PNG
(1-(7-hydroxynaphthalen-1-yl)-3-(3-methoxyphenyl)ur...)
Show SMILES COc1cccc(NC(=O)Nc2cccc3ccc(O)cc23)c1
Show InChI InChI=1S/C18H16N2O3/c1-23-15-6-3-5-13(10-15)19-18(22)20-17-7-2-4-12-8-9-14(21)11-16(12)17/h2-11,21H,1H3,(H2,19,20,22)
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n/an/a 8n/an/an/an/an/an/a



Bayer Yakuhin, Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV1 expressed in CHO cells co-expressing aequorin and CRE-luciferase reporter gene assessed as inhibition of capsaicin...


Bioorg Med Chem Lett 21: 3354-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.013
BindingDB Entry DOI: 10.7270/Q2NG4QXN
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM50344355
PNG
(1-(3-bromophenyl)-3-(7-hydroxynaphthalen-1-yl)urea...)
Show SMILES Oc1ccc2cccc(NC(=O)Nc3cccc(Br)c3)c2c1
Show InChI InChI=1S/C17H13BrN2O2/c18-12-4-2-5-13(9-12)19-17(22)20-16-6-1-3-11-7-8-14(21)10-15(11)16/h1-10,21H,(H2,19,20,22)
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n/an/a 8n/an/an/an/an/an/a



Bayer Yakuhin, Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells co-expressing aequorin and CRE-luciferase reporter gene assessed as inhibition of capsaicin-i...


Bioorg Med Chem Lett 21: 3354-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.013
BindingDB Entry DOI: 10.7270/Q2NG4QXN
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM50344352
PNG
(1-(7-hydroxynaphthalen-1-yl)-3-(3-methoxyphenyl)ur...)
Show SMILES COc1cccc(NC(=O)Nc2cccc3ccc(O)cc23)c1
Show InChI InChI=1S/C18H16N2O3/c1-23-15-6-3-5-13(10-15)19-18(22)20-17-7-2-4-12-8-9-14(21)11-16(12)17/h2-11,21H,1H3,(H2,19,20,22)
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n/an/a 8.60n/an/an/an/an/an/a



Bayer Yakuhin, Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells co-expressing aequorin and CRE-luciferase reporter gene assessed as inhibition of capsaicin-i...


Bioorg Med Chem Lett 21: 3354-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.013
BindingDB Entry DOI: 10.7270/Q2NG4QXN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM50382245
PNG
(CHEMBL2024494)
Show SMILES Oc1ccc2cccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)c2c1F
Show InChI InChI=1S/C18H11ClF4N2O2/c19-12-6-5-10(8-11(12)18(21,22)23)24-17(27)25-13-3-1-2-9-4-7-14(26)16(20)15(9)13/h1-8,26H,(H2,24,25,27)
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n/an/a 9.10n/an/an/an/an/an/a



Bayer Yakuhin, Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV1 expressed in CHOluc9aeq cells assessed as inhibition of capsaicin-stimulated response by aequorin and CRE-lucifear...


Bioorg Med Chem Lett 22: 3408-11 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.108
BindingDB Entry DOI: 10.7270/Q2C24XF7
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM50344350
PNG
(1-(7-hydroxynaphthalen-1-yl)-3-m-tolylurea | CHEMB...)
Show SMILES Cc1cccc(NC(=O)Nc2cccc3ccc(O)cc23)c1
Show InChI InChI=1S/C18H16N2O2/c1-12-4-2-6-14(10-12)19-18(22)20-17-7-3-5-13-8-9-15(21)11-16(13)17/h2-11,21H,1H3,(H2,19,20,22)
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n/an/a 11n/an/an/an/an/an/a



Bayer Yakuhin, Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV1 expressed in CHO cells co-expressing aequorin and CRE-luciferase reporter gene assessed as inhibition of capsaicin...


Bioorg Med Chem Lett 21: 3354-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.013
BindingDB Entry DOI: 10.7270/Q2NG4QXN
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM50344349
PNG
(1-(4-chlorophenyl)-3-(7-hydroxynaphthalen-1-yl)ure...)
Show SMILES Oc1ccc2cccc(NC(=O)Nc3ccc(Cl)cc3)c2c1
Show InChI InChI=1S/C17H13ClN2O2/c18-12-5-7-13(8-6-12)19-17(22)20-16-3-1-2-11-4-9-14(21)10-15(11)16/h1-10,21H,(H2,19,20,22)
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n/an/a 11n/an/an/an/an/an/a



Bayer Yakuhin, Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells co-expressing aequorin and CRE-luciferase reporter gene assessed as inhibition of capsaicin-i...


Bioorg Med Chem Lett 21: 3354-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.013
BindingDB Entry DOI: 10.7270/Q2NG4QXN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM50344364
PNG
(1-(3,5-dichlorophenyl)-3-(7-hydroxynaphthalen-1-yl...)
Show SMILES Oc1ccc2cccc(NC(=O)Nc3cc(Cl)cc(Cl)c3)c2c1
Show InChI InChI=1S/C17H12Cl2N2O2/c18-11-6-12(19)8-13(7-11)20-17(23)21-16-3-1-2-10-4-5-14(22)9-15(10)16/h1-9,22H,(H2,20,21,23)
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n/an/a 12n/an/an/an/an/an/a



Bayer Yakuhin, Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV1 expressed in CHO cells co-expressing aequorin and CRE-luciferase reporter gene assessed as inhibition of capsaicin...


Bioorg Med Chem Lett 21: 3354-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.013
BindingDB Entry DOI: 10.7270/Q2NG4QXN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM50344362
PNG
(1-(2,4-dichlorophenyl)-3-(7-hydroxynaphthalen-1-yl...)
Show SMILES Oc1ccc2cccc(NC(=O)Nc3ccc(Cl)cc3Cl)c2c1
Show InChI InChI=1S/C17H12Cl2N2O2/c18-11-5-7-16(14(19)8-11)21-17(23)20-15-3-1-2-10-4-6-12(22)9-13(10)15/h1-9,22H,(H2,20,21,23)
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n/an/a 12n/an/an/an/an/an/a



Bayer Yakuhin, Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV1 expressed in CHO cells co-expressing aequorin and CRE-luciferase reporter gene assessed as inhibition of capsaicin...


Bioorg Med Chem Lett 21: 3354-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.013
BindingDB Entry DOI: 10.7270/Q2NG4QXN
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM50344364
PNG
(1-(3,5-dichlorophenyl)-3-(7-hydroxynaphthalen-1-yl...)
Show SMILES Oc1ccc2cccc(NC(=O)Nc3cc(Cl)cc(Cl)c3)c2c1
Show InChI InChI=1S/C17H12Cl2N2O2/c18-11-6-12(19)8-13(7-11)20-17(23)21-16-3-1-2-10-4-5-14(22)9-15(10)16/h1-9,22H,(H2,20,21,23)
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n/an/a 12n/an/an/an/an/an/a



Bayer Yakuhin, Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells co-expressing aequorin and CRE-luciferase reporter gene assessed as inhibition of capsaicin-i...


Bioorg Med Chem Lett 21: 3354-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.013
BindingDB Entry DOI: 10.7270/Q2NG4QXN
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM50344366
PNG
(1-(2-chloro-5-(trifluoromethyl)phenyl)-3-(7-hydrox...)
Show SMILES Oc1ccc2cccc(NC(=O)Nc3cc(ccc3Cl)C(F)(F)F)c2c1
Show InChI InChI=1S/C18H12ClF3N2O2/c19-14-7-5-11(18(20,21)22)8-16(14)24-17(26)23-15-3-1-2-10-4-6-12(25)9-13(10)15/h1-9,25H,(H2,23,24,26)
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n/an/a 12n/an/an/an/an/an/a



Bayer Yakuhin, Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells co-expressing aequorin and CRE-luciferase reporter gene assessed as inhibition of capsaicin-i...


Bioorg Med Chem Lett 21: 3354-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.013
BindingDB Entry DOI: 10.7270/Q2NG4QXN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM50344349
PNG
(1-(4-chlorophenyl)-3-(7-hydroxynaphthalen-1-yl)ure...)
Show SMILES Oc1ccc2cccc(NC(=O)Nc3ccc(Cl)cc3)c2c1
Show InChI InChI=1S/C17H13ClN2O2/c18-12-5-7-13(8-6-12)19-17(22)20-16-3-1-2-11-4-9-14(21)10-15(11)16/h1-10,21H,(H2,19,20,22)
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n/an/a 12n/an/an/an/an/an/a



Bayer Yakuhin, Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV1 expressed in CHO cells co-expressing aequorin and CRE-luciferase reporter gene assessed as inhibition of capsaicin...


Bioorg Med Chem Lett 21: 3354-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.013
BindingDB Entry DOI: 10.7270/Q2NG4QXN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM50344366
PNG
(1-(2-chloro-5-(trifluoromethyl)phenyl)-3-(7-hydrox...)
Show SMILES Oc1ccc2cccc(NC(=O)Nc3cc(ccc3Cl)C(F)(F)F)c2c1
Show InChI InChI=1S/C18H12ClF3N2O2/c19-14-7-5-11(18(20,21)22)8-16(14)24-17(26)23-15-3-1-2-10-4-6-12(25)9-13(10)15/h1-9,25H,(H2,23,24,26)
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n/an/a 13n/an/an/an/an/an/a



Bayer Yakuhin, Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV1 expressed in CHO cells co-expressing aequorin and CRE-luciferase reporter gene assessed as inhibition of capsaicin...


Bioorg Med Chem Lett 21: 3354-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.013
BindingDB Entry DOI: 10.7270/Q2NG4QXN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM50344351
PNG
(1-(3-fluorophenyl)-3-(7-hydroxynaphthalen-1-yl)ure...)
Show SMILES Oc1ccc2cccc(NC(=O)Nc3cccc(F)c3)c2c1
Show InChI InChI=1S/C17H13FN2O2/c18-12-4-2-5-13(9-12)19-17(22)20-16-6-1-3-11-7-8-14(21)10-15(11)16/h1-10,21H,(H2,19,20,22)
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n/an/a 14n/an/an/an/an/an/a



Bayer Yakuhin, Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV1 expressed in CHO cells co-expressing aequorin and CRE-luciferase reporter gene assessed as inhibition of capsaicin...


Bioorg Med Chem Lett 21: 3354-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.013
BindingDB Entry DOI: 10.7270/Q2NG4QXN
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM50344353
PNG
(1-(7-hydroxynaphthalen-1-yl)-3-(3-nitrophenyl)urea...)
Show SMILES Oc1ccc2cccc(NC(=O)Nc3cccc(c3)[N+]([O-])=O)c2c1
Show InChI InChI=1S/C17H13N3O4/c21-14-8-7-11-3-1-6-16(15(11)10-14)19-17(22)18-12-4-2-5-13(9-12)20(23)24/h1-10,21H,(H2,18,19,22)
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n/an/a 14n/an/an/an/an/an/a



Bayer Yakuhin, Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells co-expressing aequorin and CRE-luciferase reporter gene assessed as inhibition of capsaicin-i...


Bioorg Med Chem Lett 21: 3354-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.013
BindingDB Entry DOI: 10.7270/Q2NG4QXN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM50382240
PNG
(CHEMBL2024667)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(Cl)c(c2)C(F)(F)F)c1CCO
Show InChI InChI=1S/C17H16ClF3N2O2/c1-10-3-2-4-15(12(10)7-8-24)23-16(25)22-11-5-6-14(18)13(9-11)17(19,20)21/h2-6,9,24H,7-8H2,1H3,(H2,22,23,25)
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n/an/a 16n/an/an/an/an/an/a



Bayer Yakuhin, Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV1 expressed in CHOluc9aeq cells assessed as inhibition of capsaicin-stimulated response by aequorin and CRE-lucifear...


Bioorg Med Chem Lett 22: 3408-11 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.108
BindingDB Entry DOI: 10.7270/Q2C24XF7
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM50344362
PNG
(1-(2,4-dichlorophenyl)-3-(7-hydroxynaphthalen-1-yl...)
Show SMILES Oc1ccc2cccc(NC(=O)Nc3ccc(Cl)cc3Cl)c2c1
Show InChI InChI=1S/C17H12Cl2N2O2/c18-11-5-7-16(14(19)8-11)21-17(23)20-15-3-1-2-10-4-6-12(22)9-13(10)15/h1-9,22H,(H2,20,21,23)
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n/an/a 16n/an/an/an/an/an/a



Bayer Yakuhin, Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells co-expressing aequorin and CRE-luciferase reporter gene assessed as inhibition of capsaicin-i...


Bioorg Med Chem Lett 21: 3354-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.013
BindingDB Entry DOI: 10.7270/Q2NG4QXN
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM50344373
PNG
(1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2,3-dibr...)
Show SMILES Oc1ccc2cc(Br)c(Br)c(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)c2c1
Show InChI InChI=1S/C18H10Br2ClF3N2O2/c19-13-5-8-1-3-10(27)7-11(8)16(15(13)20)26-17(28)25-9-2-4-14(21)12(6-9)18(22,23)24/h1-7,27H,(H2,25,26,28)
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n/an/a 16n/an/an/an/an/an/a



Bayer Yakuhin, Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells co-expressing aequorin and CRE-luciferase reporter gene assessed as inhibition of capsaicin-i...


Bioorg Med Chem Lett 21: 3354-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.013
BindingDB Entry DOI: 10.7270/Q2NG4QXN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM50382243
PNG
(CHEMBL2024492)
Show SMILES Oc1ccc2c(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cccc2c1
Show InChI InChI=1S/C18H12ClF3N2O2/c19-15-7-4-11(9-14(15)18(20,21)22)23-17(26)24-16-3-1-2-10-8-12(25)5-6-13(10)16/h1-9,25H,(H2,23,24,26)
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n/an/a 18n/an/an/an/an/an/a



Bayer Yakuhin, Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV1 expressed in CHOluc9aeq cells assessed as inhibition of capsaicin-stimulated response by aequorin and CRE-lucifear...


Bioorg Med Chem Lett 22: 3408-11 (2012)


Article DOI: 10.1016/j.bmcl.2012.03.108
BindingDB Entry DOI: 10.7270/Q2C24XF7
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM50344376
PNG
(1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(7-methox...)
Show SMILES COc1ccc2cccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)c2c1
Show InChI InChI=1S/C19H14ClF3N2O2/c1-27-13-7-5-11-3-2-4-17(14(11)10-13)25-18(26)24-12-6-8-16(20)15(9-12)19(21,22)23/h2-10H,1H3,(H2,24,25,26)
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n/an/a 19n/an/an/an/an/an/a



Bayer Yakuhin, Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells co-expressing aequorin and CRE-luciferase reporter gene assessed as inhibition of capsaicin-i...


Bioorg Med Chem Lett 21: 3354-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.013
BindingDB Entry DOI: 10.7270/Q2NG4QXN
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM50344365
PNG
(1-(4-chloro-2-(trifluoromethyl)phenyl)-3-(7-hydrox...)
Show SMILES Oc1ccc2cccc(NC(=O)Nc3ccc(Cl)cc3C(F)(F)F)c2c1
Show InChI InChI=1S/C18H12ClF3N2O2/c19-11-5-7-16(14(8-11)18(20,21)22)24-17(26)23-15-3-1-2-10-4-6-12(25)9-13(10)15/h1-9,25H,(H2,23,24,26)
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n/an/a 19n/an/an/an/an/an/a



Bayer Yakuhin, Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells co-expressing aequorin and CRE-luciferase reporter gene assessed as inhibition of capsaicin-i...


Bioorg Med Chem Lett 21: 3354-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.013
BindingDB Entry DOI: 10.7270/Q2NG4QXN
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM50344350
PNG
(1-(7-hydroxynaphthalen-1-yl)-3-m-tolylurea | CHEMB...)
Show SMILES Cc1cccc(NC(=O)Nc2cccc3ccc(O)cc23)c1
Show InChI InChI=1S/C18H16N2O2/c1-12-4-2-6-14(10-12)19-18(22)20-17-7-3-5-13-8-9-15(21)11-16(13)17/h2-11,21H,1H3,(H2,19,20,22)
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n/an/a 19n/an/an/an/an/an/a



Bayer Yakuhin, Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells co-expressing aequorin and CRE-luciferase reporter gene assessed as inhibition of capsaicin-i...


Bioorg Med Chem Lett 21: 3354-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.013
BindingDB Entry DOI: 10.7270/Q2NG4QXN
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM50344351
PNG
(1-(3-fluorophenyl)-3-(7-hydroxynaphthalen-1-yl)ure...)
Show SMILES Oc1ccc2cccc(NC(=O)Nc3cccc(F)c3)c2c1
Show InChI InChI=1S/C17H13FN2O2/c18-12-4-2-5-13(9-12)19-17(22)20-16-6-1-3-11-7-8-14(21)10-15(11)16/h1-10,21H,(H2,19,20,22)
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n/an/a 21n/an/an/an/an/an/a



Bayer Yakuhin, Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells co-expressing aequorin and CRE-luciferase reporter gene assessed as inhibition of capsaicin-i...


Bioorg Med Chem Lett 21: 3354-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.013
BindingDB Entry DOI: 10.7270/Q2NG4QXN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM50344361
PNG
(1-(2,5-dichlorophenyl)-3-(7-hydroxynaphthalen-1-yl...)
Show SMILES Oc1ccc2cccc(NC(=O)Nc3cc(Cl)ccc3Cl)c2c1
Show InChI InChI=1S/C17H12Cl2N2O2/c18-11-5-7-14(19)16(8-11)21-17(23)20-15-3-1-2-10-4-6-12(22)9-13(10)15/h1-9,22H,(H2,20,21,23)
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n/an/a 24n/an/an/an/an/an/a



Bayer Yakuhin, Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV1 expressed in CHO cells co-expressing aequorin and CRE-luciferase reporter gene assessed as inhibition of capsaicin...


Bioorg Med Chem Lett 21: 3354-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.013
BindingDB Entry DOI: 10.7270/Q2NG4QXN
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM50344354
PNG
(1-(3-acetylphenyl)-3-(7-hydroxynaphthalen-1-yl)ure...)
Show SMILES CC(=O)c1cccc(NC(=O)Nc2cccc3ccc(O)cc23)c1
Show InChI InChI=1S/C19H16N2O3/c1-12(22)14-5-2-6-15(10-14)20-19(24)21-18-7-3-4-13-8-9-16(23)11-17(13)18/h2-11,23H,1H3,(H2,20,21,24)
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n/an/a 28n/an/an/an/an/an/a



Bayer Yakuhin, Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV1 expressed in CHO cells co-expressing aequorin and CRE-luciferase reporter gene assessed as inhibition of capsaicin...


Bioorg Med Chem Lett 21: 3354-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.013
BindingDB Entry DOI: 10.7270/Q2NG4QXN
More data for this
Ligand-Target Pair
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