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Compile Data Set for Download or QSAR

Found 31 hits from Beijing Konruns Pharmaceutical Co., Ltd   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histone deacetylase


(Homo sapiens (human))
BDBM191641
PNG
(US9186318, 13)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCCCC(=O)NO
Show InChI InChI=1S/C33H32F2N4O7/c1-44-28-18-23-25(19-29(28)45-16-4-2-3-5-30(40)39-43)36-15-12-26(23)46-27-11-10-22(17-24(27)35)38-32(42)33(13-14-33)31(41)37-21-8-6-20(34)7-9-21/h6-12,15,17-19,43H,2-5,13-14,16H2,1H3,(H,37,41)(H,38,42)(H,39,40)
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n/an/a 8.30n/an/an/an/an/an/a



Beijing Konruns Pharmaceutical Co., Ltd

US Patent


Assay Description
The inhibitions of activities of HDAC enzymes by the compounds N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-N1...


US Patent US9186318 (2015)


BindingDB Entry DOI: 10.7270/Q2ZP44XG
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM191640
PNG
(US9186318, 9)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCC(=O)NO
Show InChI InChI=1S/C31H28F2N4O7/c1-42-26-16-21-23(17-27(26)43-14-2-3-28(38)37-41)34-13-10-24(21)44-25-9-8-20(15-22(25)33)36-30(40)31(11-12-31)29(39)35-19-6-4-18(32)5-7-19/h4-10,13,15-17,41H,2-3,11-12,14H2,1H3,(H,35,39)(H,36,40)(H,37,38)
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n/an/a 12n/an/an/an/an/an/a



Beijing Konruns Pharmaceutical Co., Ltd

US Patent


Assay Description
This example shows that the inhibitory activity of the compound, N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-...


US Patent US9186318 (2015)


BindingDB Entry DOI: 10.7270/Q2ZP44XG
More data for this
Ligand-Target Pair
AXL receptor tyrosine kinase


(Homo sapiens (Human))
BDBM191640
PNG
(US9186318, 9)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCC(=O)NO
Show InChI InChI=1S/C31H28F2N4O7/c1-42-26-16-21-23(17-27(26)43-14-2-3-28(38)37-41)34-13-10-24(21)44-25-9-8-20(15-22(25)33)36-30(40)31(11-12-31)29(39)35-19-6-4-18(32)5-7-19/h4-10,13,15-17,41H,2-3,11-12,14H2,1H3,(H,35,39)(H,36,40)(H,37,38)
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n/an/a 19n/an/an/an/an/an/a



Beijing Konruns Pharmaceutical Co., Ltd

US Patent


Assay Description
This example shows that the inhibitory activity of the compound, N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-...


US Patent US9186318 (2015)


BindingDB Entry DOI: 10.7270/Q2ZP44XG
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM191640
PNG
(US9186318, 9)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCC(=O)NO
Show InChI InChI=1S/C31H28F2N4O7/c1-42-26-16-21-23(17-27(26)43-14-2-3-28(38)37-41)34-13-10-24(21)44-25-9-8-20(15-22(25)33)36-30(40)31(11-12-31)29(39)35-19-6-4-18(32)5-7-19/h4-10,13,15-17,41H,2-3,11-12,14H2,1H3,(H,35,39)(H,36,40)(H,37,38)
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n/an/a 31n/an/an/an/an/an/a



Beijing Konruns Pharmaceutical Co., Ltd

US Patent


Assay Description
This example shows that the inhibitory activity of the compound, N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-...


US Patent US9186318 (2015)


BindingDB Entry DOI: 10.7270/Q2ZP44XG
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM191640
PNG
(US9186318, 9)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCC(=O)NO
Show InChI InChI=1S/C31H28F2N4O7/c1-42-26-16-21-23(17-27(26)43-14-2-3-28(38)37-41)34-13-10-24(21)44-25-9-8-20(15-22(25)33)36-30(40)31(11-12-31)29(39)35-19-6-4-18(32)5-7-19/h4-10,13,15-17,41H,2-3,11-12,14H2,1H3,(H,35,39)(H,36,40)(H,37,38)
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n/an/a 115n/an/an/an/an/an/a



Beijing Konruns Pharmaceutical Co., Ltd

US Patent


Assay Description
This example shows that the inhibitory activity of the compound, N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-...


US Patent US9186318 (2015)


BindingDB Entry DOI: 10.7270/Q2ZP44XG
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM191640
PNG
(US9186318, 9)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCC(=O)NO
Show InChI InChI=1S/C31H28F2N4O7/c1-42-26-16-21-23(17-27(26)43-14-2-3-28(38)37-41)34-13-10-24(21)44-25-9-8-20(15-22(25)33)36-30(40)31(11-12-31)29(39)35-19-6-4-18(32)5-7-19/h4-10,13,15-17,41H,2-3,11-12,14H2,1H3,(H,35,39)(H,36,40)(H,37,38)
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n/an/a 119n/an/an/an/an/an/a



Beijing Konruns Pharmaceutical Co., Ltd

US Patent


Assay Description
This example shows that the inhibitory activity of the compound, N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-...


US Patent US9186318 (2015)


BindingDB Entry DOI: 10.7270/Q2ZP44XG
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Re


(Homo sapiens (Human))
BDBM191640
PNG
(US9186318, 9)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCC(=O)NO
Show InChI InChI=1S/C31H28F2N4O7/c1-42-26-16-21-23(17-27(26)43-14-2-3-28(38)37-41)34-13-10-24(21)44-25-9-8-20(15-22(25)33)36-30(40)31(11-12-31)29(39)35-19-6-4-18(32)5-7-19/h4-10,13,15-17,41H,2-3,11-12,14H2,1H3,(H,35,39)(H,36,40)(H,37,38)
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n/an/a 154n/an/an/an/an/an/a



Beijing Konruns Pharmaceutical Co., Ltd

US Patent


Assay Description
This example shows that the inhibitory activity of the compound, N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-...


US Patent US9186318 (2015)


BindingDB Entry DOI: 10.7270/Q2ZP44XG
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM191640
PNG
(US9186318, 9)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCC(=O)NO
Show InChI InChI=1S/C31H28F2N4O7/c1-42-26-16-21-23(17-27(26)43-14-2-3-28(38)37-41)34-13-10-24(21)44-25-9-8-20(15-22(25)33)36-30(40)31(11-12-31)29(39)35-19-6-4-18(32)5-7-19/h4-10,13,15-17,41H,2-3,11-12,14H2,1H3,(H,35,39)(H,36,40)(H,37,38)
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n/an/a 172n/an/an/an/an/an/a



Beijing Konruns Pharmaceutical Co., Ltd

US Patent


Assay Description
This example shows that the inhibitory activity of the compound, N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-...


US Patent US9186318 (2015)


BindingDB Entry DOI: 10.7270/Q2ZP44XG
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM191640
PNG
(US9186318, 9)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCC(=O)NO
Show InChI InChI=1S/C31H28F2N4O7/c1-42-26-16-21-23(17-27(26)43-14-2-3-28(38)37-41)34-13-10-24(21)44-25-9-8-20(15-22(25)33)36-30(40)31(11-12-31)29(39)35-19-6-4-18(32)5-7-19/h4-10,13,15-17,41H,2-3,11-12,14H2,1H3,(H,35,39)(H,36,40)(H,37,38)
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n/an/a 242n/an/an/an/an/an/a



Beijing Konruns Pharmaceutical Co., Ltd

US Patent


Assay Description
The inhibitions of activities of HDAC enzymes by the compounds N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-N1...


US Patent US9186318 (2015)


BindingDB Entry DOI: 10.7270/Q2ZP44XG
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM191640
PNG
(US9186318, 9)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCC(=O)NO
Show InChI InChI=1S/C31H28F2N4O7/c1-42-26-16-21-23(17-27(26)43-14-2-3-28(38)37-41)34-13-10-24(21)44-25-9-8-20(15-22(25)33)36-30(40)31(11-12-31)29(39)35-19-6-4-18(32)5-7-19/h4-10,13,15-17,41H,2-3,11-12,14H2,1H3,(H,35,39)(H,36,40)(H,37,38)
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n/an/a 431n/an/an/an/an/an/a



Beijing Konruns Pharmaceutical Co., Ltd

US Patent


Assay Description
The inhibitions of activities of HDAC enzymes by the compounds N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-N1...


US Patent US9186318 (2015)


BindingDB Entry DOI: 10.7270/Q2ZP44XG
More data for this
Ligand-Target Pair
VEGF-receptor 2 and tyrosine-protein kinase SRC


(Homo sapiens (Human))
BDBM191640
PNG
(US9186318, 9)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCC(=O)NO
Show InChI InChI=1S/C31H28F2N4O7/c1-42-26-16-21-23(17-27(26)43-14-2-3-28(38)37-41)34-13-10-24(21)44-25-9-8-20(15-22(25)33)36-30(40)31(11-12-31)29(39)35-19-6-4-18(32)5-7-19/h4-10,13,15-17,41H,2-3,11-12,14H2,1H3,(H,35,39)(H,36,40)(H,37,38)
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n/an/a>630n/an/an/an/an/an/a



Beijing Konruns Pharmaceutical Co., Ltd

US Patent


Assay Description
This example shows that the inhibitory activity of the compound, N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-...


US Patent US9186318 (2015)


BindingDB Entry DOI: 10.7270/Q2ZP44XG
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM191640
PNG
(US9186318, 9)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCC(=O)NO
Show InChI InChI=1S/C31H28F2N4O7/c1-42-26-16-21-23(17-27(26)43-14-2-3-28(38)37-41)34-13-10-24(21)44-25-9-8-20(15-22(25)33)36-30(40)31(11-12-31)29(39)35-19-6-4-18(32)5-7-19/h4-10,13,15-17,41H,2-3,11-12,14H2,1H3,(H,35,39)(H,36,40)(H,37,38)
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n/an/a>630n/an/an/an/an/an/a



Beijing Konruns Pharmaceutical Co., Ltd

US Patent


Assay Description
This example shows that the inhibitory activity of the compound, N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-...


US Patent US9186318 (2015)


BindingDB Entry DOI: 10.7270/Q2ZP44XG
More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (human))
BDBM191641
PNG
(US9186318, 13)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCCCC(=O)NO
Show InChI InChI=1S/C33H32F2N4O7/c1-44-28-18-23-25(19-29(28)45-16-4-2-3-5-30(40)39-43)36-15-12-26(23)46-27-11-10-22(17-24(27)35)38-32(42)33(13-14-33)31(41)37-21-8-6-20(34)7-9-21/h6-12,15,17-19,43H,2-5,13-14,16H2,1H3,(H,37,41)(H,38,42)(H,39,40)
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n/an/a 1.63E+3n/an/an/an/an/an/a



Beijing Konruns Pharmaceutical Co., Ltd

US Patent


Assay Description
The inhibitions of activities of HDAC enzymes by the compounds N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-N1...


US Patent US9186318 (2015)


BindingDB Entry DOI: 10.7270/Q2ZP44XG
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (human))
BDBM191641
PNG
(US9186318, 13)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCCCC(=O)NO
Show InChI InChI=1S/C33H32F2N4O7/c1-44-28-18-23-25(19-29(28)45-16-4-2-3-5-30(40)39-43)36-15-12-26(23)46-27-11-10-22(17-24(27)35)38-32(42)33(13-14-33)31(41)37-21-8-6-20(34)7-9-21/h6-12,15,17-19,43H,2-5,13-14,16H2,1H3,(H,37,41)(H,38,42)(H,39,40)
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n/an/a 2.74E+3n/an/an/an/an/an/a



Beijing Konruns Pharmaceutical Co., Ltd

US Patent


Assay Description
The inhibitions of activities of HDAC enzymes by the compounds N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-N1...


US Patent US9186318 (2015)


BindingDB Entry DOI: 10.7270/Q2ZP44XG
More data for this
Ligand-Target Pair
Histone deacetylase 11


(Homo sapiens (human))
BDBM191641
PNG
(US9186318, 13)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCCCC(=O)NO
Show InChI InChI=1S/C33H32F2N4O7/c1-44-28-18-23-25(19-29(28)45-16-4-2-3-5-30(40)39-43)36-15-12-26(23)46-27-11-10-22(17-24(27)35)38-32(42)33(13-14-33)31(41)37-21-8-6-20(34)7-9-21/h6-12,15,17-19,43H,2-5,13-14,16H2,1H3,(H,37,41)(H,38,42)(H,39,40)
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n/an/a 6.13E+3n/an/an/an/an/an/a



Beijing Konruns Pharmaceutical Co., Ltd

US Patent


Assay Description
The inhibitions of activities of HDAC enzymes by the compounds N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-N1...


US Patent US9186318 (2015)


BindingDB Entry DOI: 10.7270/Q2ZP44XG
More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (human))
BDBM191640
PNG
(US9186318, 9)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCC(=O)NO
Show InChI InChI=1S/C31H28F2N4O7/c1-42-26-16-21-23(17-27(26)43-14-2-3-28(38)37-41)34-13-10-24(21)44-25-9-8-20(15-22(25)33)36-30(40)31(11-12-31)29(39)35-19-6-4-18(32)5-7-19/h4-10,13,15-17,41H,2-3,11-12,14H2,1H3,(H,35,39)(H,36,40)(H,37,38)
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n/an/a 8.94E+3n/an/an/an/an/an/a



Beijing Konruns Pharmaceutical Co., Ltd

US Patent


Assay Description
The inhibitions of activities of HDAC enzymes by the compounds N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-N1...


US Patent US9186318 (2015)


BindingDB Entry DOI: 10.7270/Q2ZP44XG
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM191641
PNG
(US9186318, 13)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCCCC(=O)NO
Show InChI InChI=1S/C33H32F2N4O7/c1-44-28-18-23-25(19-29(28)45-16-4-2-3-5-30(40)39-43)36-15-12-26(23)46-27-11-10-22(17-24(27)35)38-32(42)33(13-14-33)31(41)37-21-8-6-20(34)7-9-21/h6-12,15,17-19,43H,2-5,13-14,16H2,1H3,(H,37,41)(H,38,42)(H,39,40)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Beijing Konruns Pharmaceutical Co., Ltd

US Patent


Assay Description
The inhibitions of activities of HDAC enzymes by the compounds N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-N1...


US Patent US9186318 (2015)


BindingDB Entry DOI: 10.7270/Q2ZP44XG
More data for this
Ligand-Target Pair
Histone deacetylase 7 (HDAC7)


(Homo sapiens (human))
BDBM191641
PNG
(US9186318, 13)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCCCC(=O)NO
Show InChI InChI=1S/C33H32F2N4O7/c1-44-28-18-23-25(19-29(28)45-16-4-2-3-5-30(40)39-43)36-15-12-26(23)46-27-11-10-22(17-24(27)35)38-32(42)33(13-14-33)31(41)37-21-8-6-20(34)7-9-21/h6-12,15,17-19,43H,2-5,13-14,16H2,1H3,(H,37,41)(H,38,42)(H,39,40)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Beijing Konruns Pharmaceutical Co., Ltd

US Patent


Assay Description
The inhibitions of activities of HDAC enzymes by the compounds N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-N1...


US Patent US9186318 (2015)


BindingDB Entry DOI: 10.7270/Q2ZP44XG
More data for this
Ligand-Target Pair
Histone deacetylase 1/3/5/8


(Homo sapiens (Human))
BDBM191641
PNG
(US9186318, 13)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCCCC(=O)NO
Show InChI InChI=1S/C33H32F2N4O7/c1-44-28-18-23-25(19-29(28)45-16-4-2-3-5-30(40)39-43)36-15-12-26(23)46-27-11-10-22(17-24(27)35)38-32(42)33(13-14-33)31(41)37-21-8-6-20(34)7-9-21/h6-12,15,17-19,43H,2-5,13-14,16H2,1H3,(H,37,41)(H,38,42)(H,39,40)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Beijing Konruns Pharmaceutical Co., Ltd

US Patent


Assay Description
The inhibitions of activities of HDAC enzymes by the compounds N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-N1...


US Patent US9186318 (2015)


BindingDB Entry DOI: 10.7270/Q2ZP44XG
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM191641
PNG
(US9186318, 13)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCCCC(=O)NO
Show InChI InChI=1S/C33H32F2N4O7/c1-44-28-18-23-25(19-29(28)45-16-4-2-3-5-30(40)39-43)36-15-12-26(23)46-27-11-10-22(17-24(27)35)38-32(42)33(13-14-33)31(41)37-21-8-6-20(34)7-9-21/h6-12,15,17-19,43H,2-5,13-14,16H2,1H3,(H,37,41)(H,38,42)(H,39,40)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Beijing Konruns Pharmaceutical Co., Ltd

US Patent


Assay Description
The inhibitions of activities of HDAC enzymes by the compounds N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-N1...


US Patent US9186318 (2015)


BindingDB Entry DOI: 10.7270/Q2ZP44XG
More data for this
Ligand-Target Pair
Histone deacetylase 3/NCoR1


(Homo sapiens (human))
BDBM191641
PNG
(US9186318, 13)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCCCC(=O)NO
Show InChI InChI=1S/C33H32F2N4O7/c1-44-28-18-23-25(19-29(28)45-16-4-2-3-5-30(40)39-43)36-15-12-26(23)46-27-11-10-22(17-24(27)35)38-32(42)33(13-14-33)31(41)37-21-8-6-20(34)7-9-21/h6-12,15,17-19,43H,2-5,13-14,16H2,1H3,(H,37,41)(H,38,42)(H,39,40)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Beijing Konruns Pharmaceutical Co., Ltd

US Patent


Assay Description
The inhibitions of activities of HDAC enzymes by the compounds N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-N1...


US Patent US9186318 (2015)


BindingDB Entry DOI: 10.7270/Q2ZP44XG
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM191641
PNG
(US9186318, 13)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCCCC(=O)NO
Show InChI InChI=1S/C33H32F2N4O7/c1-44-28-18-23-25(19-29(28)45-16-4-2-3-5-30(40)39-43)36-15-12-26(23)46-27-11-10-22(17-24(27)35)38-32(42)33(13-14-33)31(41)37-21-8-6-20(34)7-9-21/h6-12,15,17-19,43H,2-5,13-14,16H2,1H3,(H,37,41)(H,38,42)(H,39,40)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Beijing Konruns Pharmaceutical Co., Ltd

US Patent


Assay Description
The inhibitions of activities of HDAC enzymes by the compounds N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-N1...


US Patent US9186318 (2015)


BindingDB Entry DOI: 10.7270/Q2ZP44XG
More data for this
Ligand-Target Pair
Histone deacetylase 11


(Homo sapiens (human))
BDBM191640
PNG
(US9186318, 9)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCC(=O)NO
Show InChI InChI=1S/C31H28F2N4O7/c1-42-26-16-21-23(17-27(26)43-14-2-3-28(38)37-41)34-13-10-24(21)44-25-9-8-20(15-22(25)33)36-30(40)31(11-12-31)29(39)35-19-6-4-18(32)5-7-19/h4-10,13,15-17,41H,2-3,11-12,14H2,1H3,(H,35,39)(H,36,40)(H,37,38)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Beijing Konruns Pharmaceutical Co., Ltd

US Patent


Assay Description
The inhibitions of activities of HDAC enzymes by the compounds N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-N1...


US Patent US9186318 (2015)


BindingDB Entry DOI: 10.7270/Q2ZP44XG
More data for this
Ligand-Target Pair
Histone Deacetylase 10 (HDAC10)


(Homo sapiens (human))
BDBM191640
PNG
(US9186318, 9)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCC(=O)NO
Show InChI InChI=1S/C31H28F2N4O7/c1-42-26-16-21-23(17-27(26)43-14-2-3-28(38)37-41)34-13-10-24(21)44-25-9-8-20(15-22(25)33)36-30(40)31(11-12-31)29(39)35-19-6-4-18(32)5-7-19/h4-10,13,15-17,41H,2-3,11-12,14H2,1H3,(H,35,39)(H,36,40)(H,37,38)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Beijing Konruns Pharmaceutical Co., Ltd

US Patent


Assay Description
The inhibitions of activities of HDAC enzymes by the compounds N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-N1...


US Patent US9186318 (2015)


BindingDB Entry DOI: 10.7270/Q2ZP44XG
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))
BDBM191640
PNG
(US9186318, 9)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCC(=O)NO
Show InChI InChI=1S/C31H28F2N4O7/c1-42-26-16-21-23(17-27(26)43-14-2-3-28(38)37-41)34-13-10-24(21)44-25-9-8-20(15-22(25)33)36-30(40)31(11-12-31)29(39)35-19-6-4-18(32)5-7-19/h4-10,13,15-17,41H,2-3,11-12,14H2,1H3,(H,35,39)(H,36,40)(H,37,38)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Beijing Konruns Pharmaceutical Co., Ltd

US Patent


Assay Description
The inhibitions of activities of HDAC enzymes by the compounds N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-N1...


US Patent US9186318 (2015)


BindingDB Entry DOI: 10.7270/Q2ZP44XG
More data for this
Ligand-Target Pair
Histone deacetylase 1/3/5/8


(Homo sapiens (Human))
BDBM191640
PNG
(US9186318, 9)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCC(=O)NO
Show InChI InChI=1S/C31H28F2N4O7/c1-42-26-16-21-23(17-27(26)43-14-2-3-28(38)37-41)34-13-10-24(21)44-25-9-8-20(15-22(25)33)36-30(40)31(11-12-31)29(39)35-19-6-4-18(32)5-7-19/h4-10,13,15-17,41H,2-3,11-12,14H2,1H3,(H,35,39)(H,36,40)(H,37,38)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Beijing Konruns Pharmaceutical Co., Ltd

US Patent


Assay Description
The inhibitions of activities of HDAC enzymes by the compounds N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-N1...


US Patent US9186318 (2015)


BindingDB Entry DOI: 10.7270/Q2ZP44XG
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM191640
PNG
(US9186318, 9)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCC(=O)NO
Show InChI InChI=1S/C31H28F2N4O7/c1-42-26-16-21-23(17-27(26)43-14-2-3-28(38)37-41)34-13-10-24(21)44-25-9-8-20(15-22(25)33)36-30(40)31(11-12-31)29(39)35-19-6-4-18(32)5-7-19/h4-10,13,15-17,41H,2-3,11-12,14H2,1H3,(H,35,39)(H,36,40)(H,37,38)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Beijing Konruns Pharmaceutical Co., Ltd

US Patent


Assay Description
The inhibitions of activities of HDAC enzymes by the compounds N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-N1...


US Patent US9186318 (2015)


BindingDB Entry DOI: 10.7270/Q2ZP44XG
More data for this
Ligand-Target Pair
Histone deacetylase 3/NCoR1


(Homo sapiens (human))
BDBM191640
PNG
(US9186318, 9)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCC(=O)NO
Show InChI InChI=1S/C31H28F2N4O7/c1-42-26-16-21-23(17-27(26)43-14-2-3-28(38)37-41)34-13-10-24(21)44-25-9-8-20(15-22(25)33)36-30(40)31(11-12-31)29(39)35-19-6-4-18(32)5-7-19/h4-10,13,15-17,41H,2-3,11-12,14H2,1H3,(H,35,39)(H,36,40)(H,37,38)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Beijing Konruns Pharmaceutical Co., Ltd

US Patent


Assay Description
The inhibitions of activities of HDAC enzymes by the compounds N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-N1...


US Patent US9186318 (2015)


BindingDB Entry DOI: 10.7270/Q2ZP44XG
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (human))
BDBM191640
PNG
(US9186318, 9)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCC(=O)NO
Show InChI InChI=1S/C31H28F2N4O7/c1-42-26-16-21-23(17-27(26)43-14-2-3-28(38)37-41)34-13-10-24(21)44-25-9-8-20(15-22(25)33)36-30(40)31(11-12-31)29(39)35-19-6-4-18(32)5-7-19/h4-10,13,15-17,41H,2-3,11-12,14H2,1H3,(H,35,39)(H,36,40)(H,37,38)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Beijing Konruns Pharmaceutical Co., Ltd

US Patent


Assay Description
The inhibitions of activities of HDAC enzymes by the compounds N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-N1...


US Patent US9186318 (2015)


BindingDB Entry DOI: 10.7270/Q2ZP44XG
More data for this
Ligand-Target Pair
Histone deacetylase 7 (HDAC7)


(Homo sapiens (human))
BDBM191640
PNG
(US9186318, 9)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCC(=O)NO
Show InChI InChI=1S/C31H28F2N4O7/c1-42-26-16-21-23(17-27(26)43-14-2-3-28(38)37-41)34-13-10-24(21)44-25-9-8-20(15-22(25)33)36-30(40)31(11-12-31)29(39)35-19-6-4-18(32)5-7-19/h4-10,13,15-17,41H,2-3,11-12,14H2,1H3,(H,35,39)(H,36,40)(H,37,38)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Beijing Konruns Pharmaceutical Co., Ltd

US Patent


Assay Description
The inhibitions of activities of HDAC enzymes by the compounds N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-N1...


US Patent US9186318 (2015)


BindingDB Entry DOI: 10.7270/Q2ZP44XG
More data for this
Ligand-Target Pair
Histone Deacetylase 10 (HDAC10)


(Homo sapiens (human))
BDBM191641
PNG
(US9186318, 13)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCCCC(=O)NO
Show InChI InChI=1S/C33H32F2N4O7/c1-44-28-18-23-25(19-29(28)45-16-4-2-3-5-30(40)39-43)36-15-12-26(23)46-27-11-10-22(17-24(27)35)38-32(42)33(13-14-33)31(41)37-21-8-6-20(34)7-9-21/h6-12,15,17-19,43H,2-5,13-14,16H2,1H3,(H,37,41)(H,38,42)(H,39,40)
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n/an/a 1.19E+4n/an/an/an/an/an/a



Beijing Konruns Pharmaceutical Co., Ltd

US Patent


Assay Description
The inhibitions of activities of HDAC enzymes by the compounds N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-N1...


US Patent US9186318 (2015)


BindingDB Entry DOI: 10.7270/Q2ZP44XG
More data for this
Ligand-Target Pair