BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 8 hits from BioCryst Pharmaceuticals Inc.   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Methylthioadenosine Nucleosidase(MTAN)


(Escherichia coli (strain K12))
BDBM50183258
PNG
(2-amino-4-[5-(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7...)
Show SMILES NC(CCSC[C@H]1N[C@H]([C@H](O)[C@@H]1O)c1c[nH]c2c(N)ncnc12)C(O)=O
Show InChI InChI=1S/C15H22N6O4S/c16-7(15(24)25)1-2-26-4-8-12(22)13(23)10(21-8)6-3-18-11-9(6)19-5-20-14(11)17/h3,5,7-8,10,12-13,18,21-23H,1-2,4,16H2,(H,24,25)(H2,17,19,20)/t7?,8-,10+,12-,13+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.70n/an/an/an/an/an/an/an/a



BioCryst Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli MTAN


Bioorg Med Chem Lett 16: 2662-5 (2006)


Article DOI: 10.1016/j.bmcl.2006.02.029
BindingDB Entry DOI: 10.7270/Q2RJ4J20
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Methylthioadenosine Phosphorylase (MTAP)


(Homo sapiens (human))
BDBM50140797
PNG
((2S,3S,4R,5S)-2-(4-Amino-5H-pyrrolo[3,2-d]pyrimidi...)
Show SMILES CSC[C@H]1N[C@H]([C@H](O)[C@@H]1O)c1c[nH]c2c(N)ncnc12
Show InChI InChI=1S/C12H17N5O2S/c1-20-3-6-10(18)11(19)8(17-6)5-2-14-9-7(5)15-4-16-12(9)13/h2,4,6,8,10-11,14,17-19H,3H2,1H3,(H2,13,15,16)/t6-,8+,10-,11+/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.20n/an/an/an/an/an/a



BioCryst Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against Methylthioadenosine phosphorylase


J Med Chem 47: 1322-4 (2004)


Article DOI: 10.1021/jm030455+
BindingDB Entry DOI: 10.7270/Q29W0G6V
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50195587
PNG
(1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-...)
Show SMILES OC[C@H]1N[C@H]([C@H](O)[C@@H]1O)c1c[nH]c2c1nc[nH]c2=O
Show InChI InChI=1S/C11H14N4O4/c16-2-5-9(17)10(18)7(15-5)4-1-12-8-6(4)13-3-14-11(8)19/h1,3,5,7,9-10,12,15-18H,2H2,(H,13,14,19)/t5-,7+,9-,10+/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
MMDB
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 100n/an/an/an/an/an/a



BioCryst Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human purine nucleoside phosphorylase


Bioorg Med Chem Lett 19: 2627-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.018
BindingDB Entry DOI: 10.7270/Q2VX0HFQ
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50294725
PNG
(7-((2S,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)py...)
Show SMILES OC[C@H]1N[C@H]([C@@H](O)[C@@H]1O)c1c[nH]c2c1nc[nH]c2=O
Show InChI InChI=1S/C11H14N4O4/c16-2-5-9(17)10(18)7(15-5)4-1-12-8-6(4)13-3-14-11(8)19/h1,3,5,7,9-10,12,15-18H,2H2,(H,13,14,19)/t5-,7+,9-,10-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 100n/an/an/an/an/an/a



BioCryst Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human purine nucleoside phosphorylase


Bioorg Med Chem Lett 19: 2627-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.018
BindingDB Entry DOI: 10.7270/Q2VX0HFQ
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50294726
PNG
(7-((2S,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)py...)
Show SMILES OC[C@H]1N[C@H]([C@H](O)[C@H]1O)c1c[nH]c2c1nc[nH]c2=O
Show InChI InChI=1S/C11H14N4O4/c16-2-5-9(17)10(18)7(15-5)4-1-12-8-6(4)13-3-14-11(8)19/h1,3,5,7,9-10,12,15-18H,2H2,(H,13,14,19)/t5-,7+,9+,10+/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 100n/an/an/an/an/an/a



BioCryst Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human purine nucleoside phosphorylase


Bioorg Med Chem Lett 19: 2627-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.018
BindingDB Entry DOI: 10.7270/Q2VX0HFQ
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50294728
PNG
((R)-7-((2S,3R,4S)-3,4-dihydroxy-2-(hydroxymethyl)p...)
Show SMILES OC[C@@]1(NC[C@H](O)[C@@H]1O)c1c[nH]c2c1nc[nH]c2=O
Show InChI InChI=1S/C11H14N4O4/c16-3-11(9(18)6(17)2-15-11)5-1-12-8-7(5)13-4-14-10(8)19/h1,4,6,9,12,15-18H,2-3H2,(H,13,14,19)/t6-,9-,11+/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 100n/an/an/an/an/an/a



BioCryst Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human purine nucleoside phosphorylase


Bioorg Med Chem Lett 19: 2624-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.017
BindingDB Entry DOI: 10.7270/Q2B56JR6
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50294727
PNG
(6-((2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)py...)
Show SMILES OC[C@H]1N[C@H]([C@H](O)[C@@H]1O)c1cc2nc[nH]c(=O)c2[nH]1
Show InChI InChI=1S/C11H14N4O4/c16-2-6-9(17)10(18)7(15-6)5-1-4-8(14-5)11(19)13-3-12-4/h1,3,6-7,9-10,14-18H,2H2,(H,12,13,19)/t6-,7+,9-,10+/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 100n/an/an/an/an/an/a



BioCryst Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human purine nucleoside phosphorylase


Bioorg Med Chem Lett 19: 2624-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.017
BindingDB Entry DOI: 10.7270/Q2B56JR6
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50294729
PNG
(7-((2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)py...)
Show SMILES OC[C@H]1N[C@H]([C@H](O)[C@@H]1O)c1c([nH]c2c1nc[nH]c2=O)C(O)=O
Show InChI InChI=1S/C12H14N4O6/c17-1-3-9(18)10(19)6(15-3)4-5-8(11(20)14-2-13-5)16-7(4)12(21)22/h2-3,6,9-10,15-19H,1H2,(H,21,22)(H,13,14,20)/t3-,6+,9-,10+/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 100n/an/an/an/an/an/a



BioCryst Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of human purine nucleoside phosphorylase


Bioorg Med Chem Lett 19: 2624-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.017
BindingDB Entry DOI: 10.7270/Q2B56JR6
More data for this
Ligand-Target Pair