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Compile Data Set for Download or QSAR

Found 6 hits from BioXell   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vitamin D3 receptor


(Homo sapiens (Human))
BDBM50200182
PNG
((1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-...)
Show SMILES C[C@H](CCCC(C)(C)O)[C@H]1CC[C@H]2\C(CCC[C@]12C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C
Show InChI InChI=1S/C27H44O3/c1-18(8-6-14-26(3,4)30)23-12-13-24-20(9-7-15-27(23,24)5)10-11-21-16-22(28)17-25(29)19(21)2/h10-11,18,22-25,28-30H,2,6-9,12-17H2,1,3-5H3/b20-10+,21-11-/t18-,22-,23-,24+,25+,27-/m1/s1
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Article
PubMed
n/an/an/an/a 10n/an/an/an/a



BioXell

Curated by ChEMBL


Assay Description
Activation of VDR in human THP1 cells assessed as increase in 25-hydroxyvitamin D-24-hydroxylase mRNA expression by RT-PCR


J Med Chem 52: 2204-13 (2009)


Article DOI: 10.1021/jm801365a
BindingDB Entry DOI: 10.7270/Q2MS3SPR
More data for this
Ligand-Target Pair
Vitamin D3 receptor


(Homo sapiens (Human))
BDBM50200182
PNG
((1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-...)
Show SMILES C[C@H](CCCC(C)(C)O)[C@H]1CC[C@H]2\C(CCC[C@]12C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C
Show InChI InChI=1S/C27H44O3/c1-18(8-6-14-26(3,4)30)23-12-13-24-20(9-7-15-27(23,24)5)10-11-21-16-22(28)17-25(29)19(21)2/h10-11,18,22-25,28-30H,2,6-9,12-17H2,1,3-5H3/b20-10+,21-11-/t18-,22-,23-,24+,25+,27-/m1/s1
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n/an/an/an/a 10n/an/an/an/a



BioXell

Curated by ChEMBL


Assay Description
Activation of VDR in human THP1 cells assessed as increase in cathelicidin antimicrobial peptide mRNA expression by RT-PCR


J Med Chem 52: 2204-13 (2009)


Article DOI: 10.1021/jm801365a
BindingDB Entry DOI: 10.7270/Q2MS3SPR
More data for this
Ligand-Target Pair
Vitamin D3 receptor


(Homo sapiens (Human))
BDBM50293274
PNG
(1alpha,25(OH)2-24-oxo-16-ene-20-cyclopropyl-vitami...)
Show SMILES CC(C)(O)C(=O)CCC1(CC1)C1=CC[C@H]2\C(CCC[C@]12C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C
Show InChI InChI=1S/C28H40O4/c1-18-20(16-21(29)17-23(18)30)8-7-19-6-5-12-27(4)22(19)9-10-24(27)28(14-15-28)13-11-25(31)26(2,3)32/h7-8,10,21-23,29-30,32H,1,5-6,9,11-17H2,2-4H3/b19-7+,20-8-/t21-,22+,23+,27+/m1/s1
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n/an/an/an/a 0.690n/an/an/an/a



BioXell

Curated by ChEMBL


Assay Description
Activation of VDR in human THP1 cells assessed as increase in cathelicidin antimicrobial peptide mRNA expression by RT-PCR


J Med Chem 52: 2204-13 (2009)


Article DOI: 10.1021/jm801365a
BindingDB Entry DOI: 10.7270/Q2MS3SPR
More data for this
Ligand-Target Pair
Vitamin D3 receptor


(Homo sapiens (Human))
BDBM50257431
PNG
(1,25-dihydroxy-16-ene-20-cyclopropyl-vitamin D3 | ...)
Show SMILES CC(C)(O)CCCC1(CC1)C1=CC[C@H]2\C(CCC[C@]12C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C
Show InChI InChI=1S/C28H42O3/c1-19-21(17-22(29)18-24(19)30)9-8-20-7-5-13-27(4)23(20)10-11-25(27)28(15-16-28)14-6-12-26(2,3)31/h8-9,11,22-24,29-31H,1,5-7,10,12-18H2,2-4H3/b20-8+,21-9-/t22-,23+,24+,27+/m1/s1
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PubMed
n/an/an/an/a 0.680n/an/an/an/a



BioXell

Curated by ChEMBL


Assay Description
Activation of VDR in human THP1 cells assessed as increase in cathelicidin antimicrobial peptide mRNA expression by RT-PCR


J Med Chem 52: 2204-13 (2009)


Article DOI: 10.1021/jm801365a
BindingDB Entry DOI: 10.7270/Q2MS3SPR
More data for this
Ligand-Target Pair
Vitamin D3 receptor


(Homo sapiens (Human))
BDBM50293274
PNG
(1alpha,25(OH)2-24-oxo-16-ene-20-cyclopropyl-vitami...)
Show SMILES CC(C)(O)C(=O)CCC1(CC1)C1=CC[C@H]2\C(CCC[C@]12C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C
Show InChI InChI=1S/C28H40O4/c1-18-20(16-21(29)17-23(18)30)8-7-19-6-5-12-27(4)22(19)9-10-24(27)28(14-15-28)13-11-25(31)26(2,3)32/h7-8,10,21-23,29-30,32H,1,5-6,9,11-17H2,2-4H3/b19-7+,20-8-/t21-,22+,23+,27+/m1/s1
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Article
PubMed
n/an/an/an/a 0.690n/an/an/an/a



BioXell

Curated by ChEMBL


Assay Description
Activation of VDR in human THP1 cells assessed as increase in 25-hydroxyvitamin D-24-hydroxylase mRNA expression by RT-PCR


J Med Chem 52: 2204-13 (2009)


Article DOI: 10.1021/jm801365a
BindingDB Entry DOI: 10.7270/Q2MS3SPR
More data for this
Ligand-Target Pair
Vitamin D3 receptor


(Homo sapiens (Human))
BDBM50257431
PNG
(1,25-dihydroxy-16-ene-20-cyclopropyl-vitamin D3 | ...)
Show SMILES CC(C)(O)CCCC1(CC1)C1=CC[C@H]2\C(CCC[C@]12C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C
Show InChI InChI=1S/C28H42O3/c1-19-21(17-22(29)18-24(19)30)9-8-20-7-5-13-27(4)23(20)10-11-25(27)28(15-16-28)14-6-12-26(2,3)31/h8-9,11,22-24,29-31H,1,5-7,10,12-18H2,2-4H3/b20-8+,21-9-/t22-,23+,24+,27+/m1/s1
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Article
PubMed
n/an/an/an/a 0.680n/an/an/an/a



BioXell

Curated by ChEMBL


Assay Description
Activation of VDR in human THP1 cells assessed as increase in 25-hydroxyvitamin D-24-hydroxylase mRNA expression by RT-PCR


J Med Chem 52: 2204-13 (2009)


Article DOI: 10.1021/jm801365a
BindingDB Entry DOI: 10.7270/Q2MS3SPR
More data for this
Ligand-Target Pair