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Found 32 hits from Biochemicals Research Center, Korea Institute of Science and Technology, Cheongryang, Seoul, South Korea.   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM14361
PNG
((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Show SMILES COc1ccc(cc1OC1CCCC1)C1CNC(=O)C1
Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)
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n/an/a 2n/an/an/an/an/an/a



Biochemicals Research Center, Korea Institute of Science and Technology, Cheongryang, Seoul, South Korea.

Curated by ChEMBL


Assay Description
Binding affinity to rolipram binding site in isolated rat brain by rolipram binding assay


Bioorg Med Chem Lett 11: 611-4 (2001)


Article DOI: 10.1016/s0960-894x(00)00681-8
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50219180
PNG
(CHEMBL347429)
Show SMILES Cn1c2nccc(-c3ccc(F)cc3)c2c(=O)n(Cc2ccccc2)c1=O
Show InChI InChI=1S/C21H16FN3O2/c1-24-19-18(17(11-12-23-19)15-7-9-16(22)10-8-15)20(26)25(21(24)27)13-14-5-3-2-4-6-14/h2-12H,13H2,1H3
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n/an/a 70n/an/an/an/an/an/a



Biochemicals Research Center, Korea Institute of Science and Technology, Cheongryang, Seoul, South Korea.

Curated by ChEMBL


Assay Description
Concentration for inhibitory activity against phosphodiesterase 4 from rat liver


Bioorg Med Chem Lett 11: 611-4 (2001)


Article DOI: 10.1016/s0960-894x(00)00681-8
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50346088
PNG
((1r,4r)-4-cyano-4-(3-(cyclopentyloxy)-4-methoxyphe...)
Show SMILES COc1ccc(cc1OC1CCCC1)[C@]1(CC[C@@H](CC1)C(O)=O)C#N
Show InChI InChI=1S/C20H25NO4/c1-24-17-7-6-15(12-18(17)25-16-4-2-3-5-16)20(13-21)10-8-14(9-11-20)19(22)23/h6-7,12,14,16H,2-5,8-11H2,1H3,(H,22,23)/t14-,20-
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n/an/a 110n/an/an/an/an/an/a



Biochemicals Research Center, Korea Institute of Science and Technology, Cheongryang, Seoul, South Korea.

Curated by ChEMBL


Assay Description
Concentration for inhibitory activity against phosphodiesterase 4 from rat liver


Bioorg Med Chem Lett 11: 611-4 (2001)


Article DOI: 10.1016/s0960-894x(00)00681-8
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50219184
PNG
(CHEMBL157897)
Show SMILES Cn1c2ncc(Cc3ccccc3)cc2c(=O)n(Cc2ccccc2)c1=O
Show InChI InChI=1S/C22H19N3O2/c1-24-20-19(13-18(14-23-20)12-16-8-4-2-5-9-16)21(26)25(22(24)27)15-17-10-6-3-7-11-17/h2-11,13-14H,12,15H2,1H3
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n/an/a 110n/an/an/an/an/an/a



Biochemicals Research Center, Korea Institute of Science and Technology, Cheongryang, Seoul, South Korea.

Curated by ChEMBL


Assay Description
Concentration for inhibitory activity against phosphodiesterase 4 from rat liver


Bioorg Med Chem Lett 11: 611-4 (2001)


Article DOI: 10.1016/s0960-894x(00)00681-8
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50346088
PNG
((1r,4r)-4-cyano-4-(3-(cyclopentyloxy)-4-methoxyphe...)
Show SMILES COc1ccc(cc1OC1CCCC1)[C@]1(CC[C@@H](CC1)C(O)=O)C#N
Show InChI InChI=1S/C20H25NO4/c1-24-17-7-6-15(12-18(17)25-16-4-2-3-5-16)20(13-21)10-8-14(9-11-20)19(22)23/h6-7,12,14,16H,2-5,8-11H2,1H3,(H,22,23)/t14-,20-
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n/an/a 180n/an/an/an/an/an/a



Biochemicals Research Center, Korea Institute of Science and Technology, Cheongryang, Seoul, South Korea.

Curated by ChEMBL


Assay Description
Binding affinity to rolipram binding site in isolated rat brain by rolipram binding assay


Bioorg Med Chem Lett 11: 611-4 (2001)


Article DOI: 10.1016/s0960-894x(00)00681-8
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50219177
PNG
(CHEMBL347478)
Show SMILES Cn1c2nccc(-c3ccccc3F)c2c(=O)n(Cc2ccccc2)c1=O
Show InChI InChI=1S/C21H16FN3O2/c1-24-19-18(16(11-12-23-19)15-9-5-6-10-17(15)22)20(26)25(21(24)27)13-14-7-3-2-4-8-14/h2-12H,13H2,1H3
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n/an/a 240n/an/an/an/an/an/a



Biochemicals Research Center, Korea Institute of Science and Technology, Cheongryang, Seoul, South Korea.

Curated by ChEMBL


Assay Description
Concentration for inhibitory activity against phosphodiesterase 4 from rat liver


Bioorg Med Chem Lett 11: 611-4 (2001)


Article DOI: 10.1016/s0960-894x(00)00681-8
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50219181
PNG
(CHEMBL346928)
Show SMILES Cn1c2nccc(-c3ccccc3)c2c(=O)n(Cc2ccccc2)c1=O
Show InChI InChI=1S/C21H17N3O2/c1-23-19-18(17(12-13-22-19)16-10-6-3-7-11-16)20(25)24(21(23)26)14-15-8-4-2-5-9-15/h2-13H,14H2,1H3
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n/an/a 430n/an/an/an/an/an/a



Biochemicals Research Center, Korea Institute of Science and Technology, Cheongryang, Seoul, South Korea.

Curated by ChEMBL


Assay Description
Concentration for inhibitory activity against phosphodiesterase 4 from rat liver


Bioorg Med Chem Lett 11: 611-4 (2001)


Article DOI: 10.1016/s0960-894x(00)00681-8
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50219177
PNG
(CHEMBL347478)
Show SMILES Cn1c2nccc(-c3ccccc3F)c2c(=O)n(Cc2ccccc2)c1=O
Show InChI InChI=1S/C21H16FN3O2/c1-24-19-18(16(11-12-23-19)15-9-5-6-10-17(15)22)20(26)25(21(24)27)13-14-7-3-2-4-8-14/h2-12H,13H2,1H3
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n/an/a 491n/an/an/an/an/an/a



Biochemicals Research Center, Korea Institute of Science and Technology, Cheongryang, Seoul, South Korea.

Curated by ChEMBL


Assay Description
Binding affinity to rolipram binding site in isolated rat brain by rolipram binding assay


Bioorg Med Chem Lett 11: 611-4 (2001)


Article DOI: 10.1016/s0960-894x(00)00681-8
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50219180
PNG
(CHEMBL347429)
Show SMILES Cn1c2nccc(-c3ccc(F)cc3)c2c(=O)n(Cc2ccccc2)c1=O
Show InChI InChI=1S/C21H16FN3O2/c1-24-19-18(17(11-12-23-19)15-7-9-16(22)10-8-15)20(26)25(21(24)27)13-14-5-3-2-4-6-14/h2-12H,13H2,1H3
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n/an/a 755n/an/an/an/an/an/a



Biochemicals Research Center, Korea Institute of Science and Technology, Cheongryang, Seoul, South Korea.

Curated by ChEMBL


Assay Description
Binding affinity to rolipram binding site in isolated rat brain by rolipram binding assay


Bioorg Med Chem Lett 11: 611-4 (2001)


Article DOI: 10.1016/s0960-894x(00)00681-8
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50219185
PNG
(CHEMBL157550)
Show SMILES Cn1c2nccc(-c3cccc(c3)C(F)(F)F)c2c(=O)n(Cc2ccccc2)c1=O
Show InChI InChI=1S/C22H16F3N3O2/c1-27-19-18(20(29)28(21(27)30)13-14-6-3-2-4-7-14)17(10-11-26-19)15-8-5-9-16(12-15)22(23,24)25/h2-12H,13H2,1H3
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n/an/a 950n/an/an/an/an/an/a



Biochemicals Research Center, Korea Institute of Science and Technology, Cheongryang, Seoul, South Korea.

Curated by ChEMBL


Assay Description
Concentration for inhibitory activity against phosphodiesterase 4 from rat liver


Bioorg Med Chem Lett 11: 611-4 (2001)


Article DOI: 10.1016/s0960-894x(00)00681-8
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50219185
PNG
(CHEMBL157550)
Show SMILES Cn1c2nccc(-c3cccc(c3)C(F)(F)F)c2c(=O)n(Cc2ccccc2)c1=O
Show InChI InChI=1S/C22H16F3N3O2/c1-27-19-18(20(29)28(21(27)30)13-14-6-3-2-4-7-14)17(10-11-26-19)15-8-5-9-16(12-15)22(23,24)25/h2-12H,13H2,1H3
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n/an/a 950n/an/an/an/an/an/a



Biochemicals Research Center, Korea Institute of Science and Technology, Cheongryang, Seoul, South Korea.

Curated by ChEMBL


Assay Description
Binding affinity to rolipram binding site in isolated rat brain by rolipram binding assay


Bioorg Med Chem Lett 11: 611-4 (2001)


Article DOI: 10.1016/s0960-894x(00)00681-8
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50219181
PNG
(CHEMBL346928)
Show SMILES Cn1c2nccc(-c3ccccc3)c2c(=O)n(Cc2ccccc2)c1=O
Show InChI InChI=1S/C21H17N3O2/c1-23-19-18(17(12-13-22-19)16-10-6-3-7-11-16)20(25)24(21(23)26)14-15-8-4-2-5-9-15/h2-13H,14H2,1H3
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n/an/a 1.01E+3n/an/an/an/an/an/a



Biochemicals Research Center, Korea Institute of Science and Technology, Cheongryang, Seoul, South Korea.

Curated by ChEMBL


Assay Description
Binding affinity to rolipram binding site in isolated rat brain by rolipram binding assay


Bioorg Med Chem Lett 11: 611-4 (2001)


Article DOI: 10.1016/s0960-894x(00)00681-8
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM14361
PNG
((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Show SMILES COc1ccc(cc1OC1CCCC1)C1CNC(=O)C1
Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)
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n/an/a 1.80E+3n/an/an/an/an/an/a



Biochemicals Research Center, Korea Institute of Science and Technology, Cheongryang, Seoul, South Korea.

Curated by ChEMBL


Assay Description
Concentration for inhibitory activity against phosphodiesterase 4 from rat liver


Bioorg Med Chem Lett 11: 611-4 (2001)


Article DOI: 10.1016/s0960-894x(00)00681-8
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50219193
PNG
(CHEMBL158266)
Show SMILES Cn1c2ncc(cc2c(=O)n(Cc2ccccc2)c1=O)-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C22H16F3N3O2/c1-27-19-17(20(29)28(21(27)30)13-14-7-3-2-4-8-14)11-15(12-26-19)16-9-5-6-10-18(16)22(23,24)25/h2-12H,13H2,1H3
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n/an/a 2.31E+3n/an/an/an/an/an/a



Biochemicals Research Center, Korea Institute of Science and Technology, Cheongryang, Seoul, South Korea.

Curated by ChEMBL


Assay Description
Concentration for inhibitory activity against phosphodiesterase 4 from rat liver


Bioorg Med Chem Lett 11: 611-4 (2001)


Article DOI: 10.1016/s0960-894x(00)00681-8
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50219178
PNG
(CHEMBL157832)
Show SMILES Cn1c2ncc(COCc3ccccc3)cc2c(=O)n(Cc2ccccc2)c1=O
Show InChI InChI=1S/C23H21N3O3/c1-25-21-20(22(27)26(23(25)28)14-17-8-4-2-5-9-17)12-19(13-24-21)16-29-15-18-10-6-3-7-11-18/h2-13H,14-16H2,1H3
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n/an/a 3.05E+3n/an/an/an/an/an/a



Biochemicals Research Center, Korea Institute of Science and Technology, Cheongryang, Seoul, South Korea.

Curated by ChEMBL


Assay Description
Concentration for inhibitory activity against phosphodiesterase 4 from rat liver


Bioorg Med Chem Lett 11: 611-4 (2001)


Article DOI: 10.1016/s0960-894x(00)00681-8
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50219199
PNG
(CHEMBL352034)
Show SMILES Cn1c2nccc(Cc3ccccc3)c2c(=O)n(Cc2ccccc2)c1=O
Show InChI InChI=1S/C22H19N3O2/c1-24-20-19(18(12-13-23-20)14-16-8-4-2-5-9-16)21(26)25(22(24)27)15-17-10-6-3-7-11-17/h2-13H,14-15H2,1H3
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n/an/a 3.34E+3n/an/an/an/an/an/a



Biochemicals Research Center, Korea Institute of Science and Technology, Cheongryang, Seoul, South Korea.

Curated by ChEMBL


Assay Description
Concentration for inhibitory activity against phosphodiesterase 4 from rat liver


Bioorg Med Chem Lett 11: 611-4 (2001)


Article DOI: 10.1016/s0960-894x(00)00681-8
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50219189
PNG
(CHEMBL436416)
Show SMILES CCCOCc1cnc2n(C)c(=O)n(Cc3ccccc3)c(=O)c2c1
Show InChI InChI=1S/C19H21N3O3/c1-3-9-25-13-15-10-16-17(20-11-15)21(2)19(24)22(18(16)23)12-14-7-5-4-6-8-14/h4-8,10-11H,3,9,12-13H2,1-2H3
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n/an/a 4.48E+3n/an/an/an/an/an/a



Biochemicals Research Center, Korea Institute of Science and Technology, Cheongryang, Seoul, South Korea.

Curated by ChEMBL


Assay Description
Concentration for inhibitory activity against phosphodiesterase 4 from rat liver


Bioorg Med Chem Lett 11: 611-4 (2001)


Article DOI: 10.1016/s0960-894x(00)00681-8
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50219198
PNG
(CHEMBL156232)
Show SMILES Cc1c(OCc2ccccc2)cnc2n(C)c(=O)n(Cc3ccccc3)c(=O)c12
Show InChI InChI=1S/C23H21N3O3/c1-16-19(29-15-18-11-7-4-8-12-18)13-24-21-20(16)22(27)26(23(28)25(21)2)14-17-9-5-3-6-10-17/h3-13H,14-15H2,1-2H3
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n/an/a 4.75E+3n/an/an/an/an/an/a



Biochemicals Research Center, Korea Institute of Science and Technology, Cheongryang, Seoul, South Korea.

Curated by ChEMBL


Assay Description
Concentration for inhibitory activity against phosphodiesterase 4 from rat liver


Bioorg Med Chem Lett 11: 611-4 (2001)


Article DOI: 10.1016/s0960-894x(00)00681-8
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50219183
PNG
(CHEMBL157204)
Show SMILES CCCOc1cnc2n(C)c(=O)n(Cc3ccccc3)c(=O)c2c1C
Show InChI InChI=1S/C19H21N3O3/c1-4-10-25-15-11-20-17-16(13(15)2)18(23)22(19(24)21(17)3)12-14-8-6-5-7-9-14/h5-9,11H,4,10,12H2,1-3H3
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n/an/a 5.15E+3n/an/an/an/an/an/a



Biochemicals Research Center, Korea Institute of Science and Technology, Cheongryang, Seoul, South Korea.

Curated by ChEMBL


Assay Description
Concentration for inhibitory activity against phosphodiesterase 4 from rat liver


Bioorg Med Chem Lett 11: 611-4 (2001)


Article DOI: 10.1016/s0960-894x(00)00681-8
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50219191
PNG
(CHEMBL156928)
Show SMILES Cn1c2ncc(cc2c(=O)n(Cc2ccccc2)c1=O)-c1ccc(F)cc1
Show InChI InChI=1S/C21H16FN3O2/c1-24-19-18(11-16(12-23-19)15-7-9-17(22)10-8-15)20(26)25(21(24)27)13-14-5-3-2-4-6-14/h2-12H,13H2,1H3
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n/an/a 5.75E+3n/an/an/an/an/an/a



Biochemicals Research Center, Korea Institute of Science and Technology, Cheongryang, Seoul, South Korea.

Curated by ChEMBL


Assay Description
Concentration for inhibitory activity against phosphodiesterase 4 from rat liver


Bioorg Med Chem Lett 11: 611-4 (2001)


Article DOI: 10.1016/s0960-894x(00)00681-8
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50219194
PNG
(CHEMBL158202)
Show SMILES Cn1c2ncc(COc3ccccc3)cc2c(=O)n(Cc2ccccc2)c1=O
Show InChI InChI=1S/C22H19N3O3/c1-24-20-19(12-17(13-23-20)15-28-18-10-6-3-7-11-18)21(26)25(22(24)27)14-16-8-4-2-5-9-16/h2-13H,14-15H2,1H3
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n/an/a 6.11E+3n/an/an/an/an/an/a



Biochemicals Research Center, Korea Institute of Science and Technology, Cheongryang, Seoul, South Korea.

Curated by ChEMBL


Assay Description
Concentration for inhibitory activity against phosphodiesterase 4 from rat liver


Bioorg Med Chem Lett 11: 611-4 (2001)


Article DOI: 10.1016/s0960-894x(00)00681-8
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50219195
PNG
(CHEMBL423595)
Show SMILES Cn1c2ncc(cc2c(=O)n(Cc2ccccc2)c1=O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H16ClN3O2/c1-24-19-18(11-16(12-23-19)15-7-9-17(22)10-8-15)20(26)25(21(24)27)13-14-5-3-2-4-6-14/h2-12H,13H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Biochemicals Research Center, Korea Institute of Science and Technology, Cheongryang, Seoul, South Korea.

Curated by ChEMBL


Assay Description
Concentration for inhibitory activity against phosphodiesterase 4 from rat liver


Bioorg Med Chem Lett 11: 611-4 (2001)


Article DOI: 10.1016/s0960-894x(00)00681-8
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50219179
PNG
(CHEMBL156010)
Show SMILES CCOc1ccc(cc1)-c1cnc2n(C)c(=O)n(Cc3ccccc3)c(=O)c2c1
Show InChI InChI=1S/C23H21N3O3/c1-3-29-19-11-9-17(10-12-19)18-13-20-21(24-14-18)25(2)23(28)26(22(20)27)15-16-7-5-4-6-8-16/h4-14H,3,15H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Biochemicals Research Center, Korea Institute of Science and Technology, Cheongryang, Seoul, South Korea.

Curated by ChEMBL


Assay Description
Concentration for inhibitory activity against phosphodiesterase 4 from rat liver


Bioorg Med Chem Lett 11: 611-4 (2001)


Article DOI: 10.1016/s0960-894x(00)00681-8
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50219196
PNG
(CHEMBL157308)
Show SMILES Cn1c2ncc(cc2c(=O)n(Cc2ccccc2)c1=O)-c1cccc(c1)[N+]([O-])=O
Show InChI InChI=1S/C21H16N4O4/c1-23-19-18(20(26)24(21(23)27)13-14-6-3-2-4-7-14)11-16(12-22-19)15-8-5-9-17(10-15)25(28)29/h2-12H,13H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Biochemicals Research Center, Korea Institute of Science and Technology, Cheongryang, Seoul, South Korea.

Curated by ChEMBL


Assay Description
Concentration for inhibitory activity against phosphodiesterase 4 from rat liver


Bioorg Med Chem Lett 11: 611-4 (2001)


Article DOI: 10.1016/s0960-894x(00)00681-8
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50219197
PNG
(CHEMBL440917)
Show SMILES Cn1c2ncc(cc2c(=O)n(Cc2ccccc2)c1=O)C#N
Show InChI InChI=1S/C16H12N4O2/c1-19-14-13(7-12(8-17)9-18-14)15(21)20(16(19)22)10-11-5-3-2-4-6-11/h2-7,9H,10H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Biochemicals Research Center, Korea Institute of Science and Technology, Cheongryang, Seoul, South Korea.

Curated by ChEMBL


Assay Description
Concentration for inhibitory activity against phosphodiesterase 4 from rat liver


Bioorg Med Chem Lett 11: 611-4 (2001)


Article DOI: 10.1016/s0960-894x(00)00681-8
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50219182
PNG
(CHEMBL156054)
Show SMILES CCOc1ccc(cc1)-c1ccnc2n(C)c(=O)n(Cc3ccccc3)c(=O)c12
Show InChI InChI=1S/C23H21N3O3/c1-3-29-18-11-9-17(10-12-18)19-13-14-24-21-20(19)22(27)26(23(28)25(21)2)15-16-7-5-4-6-8-16/h4-14H,3,15H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Biochemicals Research Center, Korea Institute of Science and Technology, Cheongryang, Seoul, South Korea.

Curated by ChEMBL


Assay Description
Concentration for inhibitory activity against phosphodiesterase 4 from rat liver


Bioorg Med Chem Lett 11: 611-4 (2001)


Article DOI: 10.1016/s0960-894x(00)00681-8
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50219192
PNG
(CHEMBL156742)
Show SMILES CCOC(=O)c1cnc2n(C)c(=O)n(Cc3ccccc3)c(=O)c2c1
Show InChI InChI=1S/C18H17N3O4/c1-3-25-17(23)13-9-14-15(19-10-13)20(2)18(24)21(16(14)22)11-12-7-5-4-6-8-12/h4-10H,3,11H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Biochemicals Research Center, Korea Institute of Science and Technology, Cheongryang, Seoul, South Korea.

Curated by ChEMBL


Assay Description
Concentration for inhibitory activity against phosphodiesterase 4 from rat liver


Bioorg Med Chem Lett 11: 611-4 (2001)


Article DOI: 10.1016/s0960-894x(00)00681-8
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50219187
PNG
(CHEMBL156985)
Show SMILES Cn1c2ncc(cc2c(=O)n(Cc2ccccc2)c1=O)-c1ccccc1F
Show InChI InChI=1S/C21H16FN3O2/c1-24-19-17(11-15(12-23-19)16-9-5-6-10-18(16)22)20(26)25(21(24)27)13-14-7-3-2-4-8-14/h2-12H,13H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Biochemicals Research Center, Korea Institute of Science and Technology, Cheongryang, Seoul, South Korea.

Curated by ChEMBL


Assay Description
Concentration for inhibitory activity against phosphodiesterase 4 from rat liver


Bioorg Med Chem Lett 11: 611-4 (2001)


Article DOI: 10.1016/s0960-894x(00)00681-8
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50219186
PNG
(CHEMBL155536)
Show SMILES Cn1c2ncc(cc2c(=O)n(Cc2ccccc2)c1=O)-c1ccccc1
Show InChI InChI=1S/C21H17N3O2/c1-23-19-18(12-17(13-22-19)16-10-6-3-7-11-16)20(25)24(21(23)26)14-15-8-4-2-5-9-15/h2-13H,14H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Biochemicals Research Center, Korea Institute of Science and Technology, Cheongryang, Seoul, South Korea.

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 4 from rat liver at 0.3 uM (not determined)


Bioorg Med Chem Lett 11: 611-4 (2001)


Article DOI: 10.1016/s0960-894x(00)00681-8
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50219190
PNG
(CHEMBL154936)
Show SMILES CCCCOc1ccnc2n(C)c(=O)n(Cc3ccccc3)c(=O)c12
Show InChI InChI=1S/C19H21N3O3/c1-3-4-12-25-15-10-11-20-17-16(15)18(23)22(19(24)21(17)2)13-14-8-6-5-7-9-14/h5-11H,3-4,12-13H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Biochemicals Research Center, Korea Institute of Science and Technology, Cheongryang, Seoul, South Korea.

Curated by ChEMBL


Assay Description
Concentration for inhibitory activity against phosphodiesterase 4 from rat liver


Bioorg Med Chem Lett 11: 611-4 (2001)


Article DOI: 10.1016/s0960-894x(00)00681-8
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50219188
PNG
(CHEMBL346569)
Show SMILES Cn1c2ncc(cc2c(=O)n(Cc2ccccc2)c1=O)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C22H16F3N3O2/c1-27-19-18(20(29)28(21(27)30)13-14-6-3-2-4-7-14)11-16(12-26-19)15-8-5-9-17(10-15)22(23,24)25/h2-12H,13H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Biochemicals Research Center, Korea Institute of Science and Technology, Cheongryang, Seoul, South Korea.

Curated by ChEMBL


Assay Description
Concentration for inhibitory activity against phosphodiesterase 4 from rat liver


Bioorg Med Chem Lett 11: 611-4 (2001)


Article DOI: 10.1016/s0960-894x(00)00681-8
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50219184
PNG
(CHEMBL157897)
Show SMILES Cn1c2ncc(Cc3ccccc3)cc2c(=O)n(Cc2ccccc2)c1=O
Show InChI InChI=1S/C22H19N3O2/c1-24-20-19(13-18(14-23-20)12-16-8-4-2-5-9-16)21(26)25(22(24)27)15-17-10-6-3-7-11-17/h2-11,13-14H,12,15H2,1H3
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n/an/a 2.34E+4n/an/an/an/an/an/a



Biochemicals Research Center, Korea Institute of Science and Technology, Cheongryang, Seoul, South Korea.

Curated by ChEMBL


Assay Description
Binding affinity to rolipram binding site in isolated rat brain by rolipram binding assay


Bioorg Med Chem Lett 11: 611-4 (2001)


Article DOI: 10.1016/s0960-894x(00)00681-8
More data for this
Ligand-Target Pair