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Compile Data Set for Download or QSAR

Found 89 hits from Biofor Inc.   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50033318
PNG
(Benzyl-(6-ethynyl-2-imidazol-1-yl-quinazolin-4-yl)...)
Show SMILES C#Cc1ccc2nc(nc(NCc3ccccc3)c2c1)-n1ccnc1
Show InChI InChI=1S/C20H15N5/c1-2-15-8-9-18-17(12-15)19(22-13-16-6-4-3-5-7-16)24-20(23-18)25-11-10-21-14-25/h1,3-12,14H,13H2,(H,22,23,24)
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n/an/a 0.530n/an/an/an/an/an/a



Biofor Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 5 from human platelets


J Med Chem 38: 3547-57 (1995)


Article DOI: 10.1021/jm00018a014
BindingDB Entry DOI: 10.7270/Q2F190CB
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50033343
PNG
(Benzyl-(6-bromo-2-imidazol-1-yl-quinazolin-4-yl)-a...)
Show SMILES Brc1ccc2nc(nc(NCc3ccccc3)c2c1)-n1ccnc1
Show InChI InChI=1S/C18H14BrN5/c19-14-6-7-16-15(10-14)17(21-11-13-4-2-1-3-5-13)23-18(22-16)24-9-8-20-12-24/h1-10,12H,11H2,(H,21,22,23)
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n/an/a 2.30n/an/an/an/an/an/a



Biofor Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 5 from human platelets


J Med Chem 38: 3547-57 (1995)


Article DOI: 10.1021/jm00018a014
BindingDB Entry DOI: 10.7270/Q2F190CB
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50033313
PNG
(Benzyl-(2-imidazol-1-yl-6-nitro-quinazolin-4-yl)-a...)
Show SMILES [O-][N+](=O)c1ccc2nc(nc(NCc3ccccc3)c2c1)-n1ccnc1
Show InChI InChI=1S/C18H14N6O2/c25-24(26)14-6-7-16-15(10-14)17(20-11-13-4-2-1-3-5-13)22-18(21-16)23-9-8-19-12-23/h1-10,12H,11H2,(H,20,21,22)
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n/an/a 2.60n/an/an/an/an/an/a



Biofor Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 5 from human platelets


J Med Chem 38: 3547-57 (1995)


Article DOI: 10.1021/jm00018a014
BindingDB Entry DOI: 10.7270/Q2F190CB
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50033312
PNG
(Benzyl-(6-chloro-2-imidazol-1-yl-quinazolin-4-yl)-...)
Show SMILES Clc1ccc2nc(nc(NCc3ccccc3)c2c1)-n1ccnc1
Show InChI InChI=1S/C18H14ClN5/c19-14-6-7-16-15(10-14)17(21-11-13-4-2-1-3-5-13)23-18(22-16)24-9-8-20-12-24/h1-10,12H,11H2,(H,21,22,23)
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n/an/a 2.80n/an/an/an/an/an/a



Biofor Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 5 from human platelets


J Med Chem 38: 3547-57 (1995)


Article DOI: 10.1021/jm00018a014
BindingDB Entry DOI: 10.7270/Q2F190CB
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50033306
PNG
(Benzyl-(6-nitro-2-pyridin-3-yl-quinazolin-4-yl)-am...)
Show SMILES [O-][N+](=O)c1ccc2nc(nc(NCc3ccccc3)c2c1)-c1cccnc1
Show InChI InChI=1S/C20H15N5O2/c26-25(27)16-8-9-18-17(11-16)20(22-12-14-5-2-1-3-6-14)24-19(23-18)15-7-4-10-21-13-15/h1-11,13H,12H2,(H,22,23,24)
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n/an/a 10n/an/an/an/an/an/a



Biofor Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 5 from human platelets


J Med Chem 38: 3547-57 (1995)


Article DOI: 10.1021/jm00018a014
BindingDB Entry DOI: 10.7270/Q2F190CB
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50033328
PNG
(Benzyl-(2-imidazol-1-yl-6-methylsulfanyl-quinazoli...)
Show SMILES CSc1ccc2nc(nc(NCc3ccccc3)c2c1)-n1ccnc1
Show InChI InChI=1S/C19H17N5S/c1-25-15-7-8-17-16(11-15)18(21-12-14-5-3-2-4-6-14)23-19(22-17)24-10-9-20-13-24/h2-11,13H,12H2,1H3,(H,21,22,23)
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n/an/a 14n/an/an/an/an/an/a



Biofor Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 5 from human platelets


J Med Chem 38: 3547-57 (1995)


Article DOI: 10.1021/jm00018a014
BindingDB Entry DOI: 10.7270/Q2F190CB
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50033293
PNG
(Benzyl-(2-imidazol-1-yl-6-methoxy-quinazolin-4-yl)...)
Show SMILES COc1ccc2nc(nc(NCc3ccccc3)c2c1)-n1ccnc1
Show InChI InChI=1S/C19H17N5O/c1-25-15-7-8-17-16(11-15)18(21-12-14-5-3-2-4-6-14)23-19(22-17)24-10-9-20-13-24/h2-11,13H,12H2,1H3,(H,21,22,23)
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n/an/a 16n/an/an/an/an/an/a



Biofor Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 5 from human platelets


J Med Chem 38: 3547-57 (1995)


Article DOI: 10.1021/jm00018a014
BindingDB Entry DOI: 10.7270/Q2F190CB
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50033287
PNG
(Benzyl-(6-chloro-2-pyridin-3-yl-quinazolin-4-yl)-a...)
Show SMILES Clc1ccc2nc(nc(NCc3ccccc3)c2c1)-c1cccnc1
Show InChI InChI=1S/C20H15ClN4/c21-16-8-9-18-17(11-16)20(23-12-14-5-2-1-3-6-14)25-19(24-18)15-7-4-10-22-13-15/h1-11,13H,12H2,(H,23,24,25)
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n/an/a 26n/an/an/an/an/an/a



Biofor Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 5 from human platelets


J Med Chem 38: 3547-57 (1995)


Article DOI: 10.1021/jm00018a014
BindingDB Entry DOI: 10.7270/Q2F190CB
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50033334
PNG
(CHEMBL542707 | Furan-2-ylmethyl-(2-imidazol-1-yl-6...)
Show SMILES COc1ccc2nc(nc(NCc3ccco3)c2c1)-n1ccnc1
Show InChI InChI=1S/C17H15N5O2/c1-23-12-4-5-15-14(9-12)16(19-10-13-3-2-8-24-13)21-17(20-15)22-7-6-18-11-22/h2-9,11H,10H2,1H3,(H,19,20,21)
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n/an/a 72n/an/an/an/an/an/a



Biofor Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 5 from human platelets


J Med Chem 38: 3547-57 (1995)


Article DOI: 10.1021/jm00018a014
BindingDB Entry DOI: 10.7270/Q2F190CB
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50033289
PNG
(Benzyl-(6-methyl-2-pyridin-3-yl-quinazolin-4-yl)-a...)
Show SMILES Cc1ccc2nc(nc(NCc3ccccc3)c2c1)-c1cccnc1
Show InChI InChI=1S/C21H18N4/c1-15-9-10-19-18(12-15)21(23-13-16-6-3-2-4-7-16)25-20(24-19)17-8-5-11-22-14-17/h2-12,14H,13H2,1H3,(H,23,24,25)
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n/an/a 105n/an/an/an/an/an/a



Biofor Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 5 from human platelets


J Med Chem 38: 3547-57 (1995)


Article DOI: 10.1021/jm00018a014
BindingDB Entry DOI: 10.7270/Q2F190CB
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50033301
PNG
(Benzyl-(2-imidazol-1-yl-6-methanesulfonyl-quinazol...)
Show SMILES CS(=O)(=O)c1ccc2nc(nc(NCc3ccccc3)c2c1)-n1ccnc1
Show InChI InChI=1S/C19H17N5O2S/c1-27(25,26)15-7-8-17-16(11-15)18(21-12-14-5-3-2-4-6-14)23-19(22-17)24-10-9-20-13-24/h2-11,13H,12H2,1H3,(H,21,22,23)
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n/an/a 110n/an/an/an/an/an/a



Biofor Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 5 from human platelets


J Med Chem 38: 3547-57 (1995)


Article DOI: 10.1021/jm00018a014
BindingDB Entry DOI: 10.7270/Q2F190CB
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50033315
PNG
((6-Chloro-2-pyridin-3-yl-quinazolin-4-yl)-furan-2-...)
Show SMILES Clc1ccc2nc(nc(NCc3ccco3)c2c1)-c1cccnc1
Show InChI InChI=1S/C18H13ClN4O/c19-13-5-6-16-15(9-13)18(21-11-14-4-2-8-24-14)23-17(22-16)12-3-1-7-20-10-12/h1-10H,11H2,(H,21,22,23)
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n/an/a 120n/an/an/an/an/an/a



Biofor Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 5 from human platelets


J Med Chem 38: 3547-57 (1995)


Article DOI: 10.1021/jm00018a014
BindingDB Entry DOI: 10.7270/Q2F190CB
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50033336
PNG
(Benzyl-(6-fluoro-2-pyridin-3-yl-quinazolin-4-yl)-a...)
Show SMILES Fc1ccc2nc(nc(NCc3ccccc3)c2c1)-c1cccnc1
Show InChI InChI=1S/C20H15FN4/c21-16-8-9-18-17(11-16)20(23-12-14-5-2-1-3-6-14)25-19(24-18)15-7-4-10-22-13-15/h1-11,13H,12H2,(H,23,24,25)
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n/an/a 165n/an/an/an/an/an/a



Biofor Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 5 from human platelets


J Med Chem 38: 3547-57 (1995)


Article DOI: 10.1021/jm00018a014
BindingDB Entry DOI: 10.7270/Q2F190CB
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50033304
PNG
(3-(2-Phenyl-quinazolin-4-ylamino)-benzoic acid met...)
Show SMILES COC(=O)c1cccc(Nc2nc(nc3ccccc23)-c2ccccc2)c1
Show InChI InChI=1S/C22H17N3O2/c1-27-22(26)16-10-7-11-17(14-16)23-21-18-12-5-6-13-19(18)24-20(25-21)15-8-3-2-4-9-15/h2-14H,1H3,(H,23,24,25)
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n/an/a 190n/an/an/an/an/an/a



Biofor Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 5 from human platelets


J Med Chem 38: 3547-57 (1995)


Article DOI: 10.1021/jm00018a014
BindingDB Entry DOI: 10.7270/Q2F190CB
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50033349
PNG
((2-Imidazol-1-yl-quinazolin-4-yl)-thiophen-2-ylmet...)
Show SMILES C(Nc1nc(nc2ccccc12)-n1ccnc1)c1cccs1
Show InChI InChI=1S/C16H13N5S/c1-2-6-14-13(5-1)15(18-10-12-4-3-9-22-12)20-16(19-14)21-8-7-17-11-21/h1-9,11H,10H2,(H,18,19,20)
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n/an/a 210n/an/an/an/an/an/a



Biofor Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 5 from human platelets


J Med Chem 38: 3547-57 (1995)


Article DOI: 10.1021/jm00018a014
BindingDB Entry DOI: 10.7270/Q2F190CB
More data for this
Ligand-Target Pair
Thromboxane A2 Synthase (P450 TxA2)


(Homo sapiens (human))
BDBM50033290
PNG
(Benzyl-(2-imidazol-1-yl-quinazolin-4-yl)-amine | C...)
Show SMILES C(Nc1nc(nc2ccccc12)-n1ccnc1)c1ccccc1
Show InChI InChI=1S/C18H15N5/c1-2-6-14(7-3-1)12-20-17-15-8-4-5-9-16(15)21-18(22-17)23-11-10-19-13-23/h1-11,13H,12H2,(H,20,21,22)
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n/an/a 220n/an/an/an/an/an/a



Biofor Inc.

Curated by ChEMBL


Assay Description
In vitro inhibition of Thromboxane A2 synthase in human platelet


J Med Chem 38: 3547-57 (1995)


Article DOI: 10.1021/jm00018a014
BindingDB Entry DOI: 10.7270/Q2F190CB
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50033348
PNG
(CHEMBL554946 | Cyclohexylmethyl-(2-imidazol-1-yl-q...)
Show SMILES C(Nc1nc(nc2ccccc12)-n1ccnc1)C1CCCCC1
Show InChI InChI=1S/C18H21N5/c1-2-6-14(7-3-1)12-20-17-15-8-4-5-9-16(15)21-18(22-17)23-11-10-19-13-23/h4-5,8-11,13-14H,1-3,6-7,12H2,(H,20,21,22)
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n/an/a 230n/an/an/an/an/an/a



Biofor Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 5 from human platelets


J Med Chem 38: 3547-57 (1995)


Article DOI: 10.1021/jm00018a014
BindingDB Entry DOI: 10.7270/Q2F190CB
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50033290
PNG
(Benzyl-(2-imidazol-1-yl-quinazolin-4-yl)-amine | C...)
Show SMILES C(Nc1nc(nc2ccccc12)-n1ccnc1)c1ccccc1
Show InChI InChI=1S/C18H15N5/c1-2-6-14(7-3-1)12-20-17-15-8-4-5-9-16(15)21-18(22-17)23-11-10-19-13-23/h1-11,13H,12H2,(H,20,21,22)
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n/an/a 260n/an/an/an/an/an/a



Biofor Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 5 from human platelets


J Med Chem 38: 3547-57 (1995)


Article DOI: 10.1021/jm00018a014
BindingDB Entry DOI: 10.7270/Q2F190CB
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50033302
PNG
(Benzyl-(2-pyridin-4-yl-quinazolin-4-yl)-amine | CH...)
Show SMILES C(Nc1nc(nc2ccccc12)-c1ccncc1)c1ccccc1
Show InChI InChI=1S/C20H16N4/c1-2-6-15(7-3-1)14-22-20-17-8-4-5-9-18(17)23-19(24-20)16-10-12-21-13-11-16/h1-13H,14H2,(H,22,23,24)
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n/an/a 310n/an/an/an/an/an/a



Biofor Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 5 from human platelets


J Med Chem 38: 3547-57 (1995)


Article DOI: 10.1021/jm00018a014
BindingDB Entry DOI: 10.7270/Q2F190CB
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50033296
PNG
(Benzyl-(2-phenyl-quinazolin-4-yl)-amine | CHEMBL72...)
Show SMILES C(Nc1nc(nc2ccccc12)-c1ccccc1)c1ccccc1
Show InChI InChI=1S/C21H17N3/c1-3-9-16(10-4-1)15-22-21-18-13-7-8-14-19(18)23-20(24-21)17-11-5-2-6-12-17/h1-14H,15H2,(H,22,23,24)
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n/an/a 320n/an/an/an/an/an/a



Biofor Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 5 from human platelets


J Med Chem 38: 3547-57 (1995)


Article DOI: 10.1021/jm00018a014
BindingDB Entry DOI: 10.7270/Q2F190CB
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM69375
PNG
(2-(3-pyridinyl)-N-(thiophen-2-ylmethyl)-4-quinazol...)
Show SMILES C(Nc1nc(nc2ccccc12)-c1cccnc1)c1cccs1
Show InChI InChI=1S/C18H14N4S/c1-2-8-16-15(7-1)18(20-12-14-6-4-10-23-14)22-17(21-16)13-5-3-9-19-11-13/h1-11H,12H2,(H,20,21,22)
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n/an/a 360n/an/an/an/an/an/a



Biofor Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 5 from human platelets


J Med Chem 38: 3547-57 (1995)


Article DOI: 10.1021/jm00018a014
BindingDB Entry DOI: 10.7270/Q2F190CB
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50033324
PNG
((3-Nitro-phenyl)-(2-phenyl-quinazolin-4-yl)-amine ...)
Show SMILES [O-][N+](=O)c1cccc(Nc2nc(nc3ccccc23)-c2ccccc2)c1
Show InChI InChI=1S/C20H14N4O2/c25-24(26)16-10-6-9-15(13-16)21-20-17-11-4-5-12-18(17)22-19(23-20)14-7-2-1-3-8-14/h1-13H,(H,21,22,23)
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n/an/a 420n/an/an/an/an/an/a



Biofor Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 5 from human platelets


J Med Chem 38: 3547-57 (1995)


Article DOI: 10.1021/jm00018a014
BindingDB Entry DOI: 10.7270/Q2F190CB
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50033284
PNG
(Benzyl-(2-pyridin-3-yl-quinazolin-4-yl)-amine | CH...)
Show SMILES C(Nc1nc(nc2ccccc12)-c1cccnc1)c1ccccc1
Show InChI InChI=1S/C20H16N4/c1-2-7-15(8-3-1)13-22-20-17-10-4-5-11-18(17)23-19(24-20)16-9-6-12-21-14-16/h1-12,14H,13H2,(H,22,23,24)
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n/an/a 450n/an/an/an/an/an/a



Biofor Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 5 from human platelets


J Med Chem 38: 3547-57 (1995)


Article DOI: 10.1021/jm00018a014
BindingDB Entry DOI: 10.7270/Q2F190CB
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50033325
PNG
(Benzyl-(7-fluoro-2-pyridin-3-yl-quinazolin-4-yl)-a...)
Show SMILES Fc1ccc2c(NCc3ccccc3)nc(nc2c1)-c1cccnc1
Show InChI InChI=1S/C20H15FN4/c21-16-8-9-17-18(11-16)24-19(15-7-4-10-22-13-15)25-20(17)23-12-14-5-2-1-3-6-14/h1-11,13H,12H2,(H,23,24,25)
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n/an/a 480n/an/an/an/an/an/a



Biofor Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 5 from human platelets


J Med Chem 38: 3547-57 (1995)


Article DOI: 10.1021/jm00018a014
BindingDB Entry DOI: 10.7270/Q2F190CB
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50033286
PNG
(CHEMBL544818 | Phenethyl-(2-pyridin-3-yl-quinazoli...)
Show SMILES C(Cc1ccccc1)Nc1nc(nc2ccccc12)-c1cccnc1
Show InChI InChI=1S/C21H18N4/c1-2-7-16(8-3-1)12-14-23-21-18-10-4-5-11-19(18)24-20(25-21)17-9-6-13-22-15-17/h1-11,13,15H,12,14H2,(H,23,24,25)
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n/an/a 540n/an/an/an/an/an/a



Biofor Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 5 from human platelets


J Med Chem 38: 3547-57 (1995)


Article DOI: 10.1021/jm00018a014
BindingDB Entry DOI: 10.7270/Q2F190CB
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50033354
PNG
(CHEMBL540318 | Furan-2-ylmethyl-(2-imidazol-1-yl-q...)
Show SMILES C(Nc1nc(nc2ccccc12)-n1ccnc1)c1ccco1
Show InChI InChI=1S/C16H13N5O/c1-2-6-14-13(5-1)15(18-10-12-4-3-9-22-12)20-16(19-14)21-8-7-17-11-21/h1-9,11H,10H2,(H,18,19,20)
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n/an/a 630n/an/an/an/an/an/a



Biofor Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 5 from human platelets


J Med Chem 38: 3547-57 (1995)


Article DOI: 10.1021/jm00018a014
BindingDB Entry DOI: 10.7270/Q2F190CB
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50033291
PNG
(Benzyl-(2-thiophen-2-yl-quinazolin-4-yl)-amine | C...)
Show SMILES C(Nc1nc(nc2ccccc12)-c1cccs1)c1ccccc1
Show InChI InChI=1S/C19H15N3S/c1-2-7-14(8-3-1)13-20-18-15-9-4-5-10-16(15)21-19(22-18)17-11-6-12-23-17/h1-12H,13H2,(H,20,21,22)
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n/an/a 720n/an/an/an/an/an/a



Biofor Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 5 from human platelets


J Med Chem 38: 3547-57 (1995)


Article DOI: 10.1021/jm00018a014
BindingDB Entry DOI: 10.7270/Q2F190CB
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50033342
PNG
((4-Chloro-benzyl)-(2-phenyl-quinazolin-4-yl)-amine...)
Show SMILES Clc1ccc(CNc2nc(nc3ccccc23)-c2ccccc2)cc1
Show InChI InChI=1S/C21H16ClN3/c22-17-12-10-15(11-13-17)14-23-21-18-8-4-5-9-19(18)24-20(25-21)16-6-2-1-3-7-16/h1-13H,14H2,(H,23,24,25)
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n/an/a 740n/an/an/an/an/an/a



Biofor Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 5 from human platelets


J Med Chem 38: 3547-57 (1995)


Article DOI: 10.1021/jm00018a014
BindingDB Entry DOI: 10.7270/Q2F190CB
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM69864
PNG
((3-methoxyphenyl)-(2-phenylquinazolin-4-yl)amine |...)
Show SMILES COc1cccc(Nc2nc(nc3ccccc23)-c2ccccc2)c1
Show InChI InChI=1S/C21H17N3O/c1-25-17-11-7-10-16(14-17)22-21-18-12-5-6-13-19(18)23-20(24-21)15-8-3-2-4-9-15/h2-14H,1H3,(H,22,23,24)
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n/an/a 760n/an/an/an/an/an/a



Biofor Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 5 from human platelets


J Med Chem 38: 3547-57 (1995)


Article DOI: 10.1021/jm00018a014
BindingDB Entry DOI: 10.7270/Q2F190CB
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50033305
PNG
((2-Chloro-benzyl)-(2-phenyl-quinazolin-4-yl)-amine...)
Show SMILES Clc1ccccc1CNc1nc(nc2ccccc12)-c1ccccc1
Show InChI InChI=1S/C21H16ClN3/c22-18-12-6-4-10-16(18)14-23-21-17-11-5-7-13-19(17)24-20(25-21)15-8-2-1-3-9-15/h1-13H,14H2,(H,23,24,25)
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n/an/a 800n/an/an/an/an/an/a



Biofor Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 5 from human platelets


J Med Chem 38: 3547-57 (1995)


Article DOI: 10.1021/jm00018a014
BindingDB Entry DOI: 10.7270/Q2F190CB
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50033352
PNG
((3-Chloro-benzyl)-(2-phenyl-quinazolin-4-yl)-amine...)
Show SMILES Clc1cccc(CNc2nc(nc3ccccc23)-c2ccccc2)c1
Show InChI InChI=1S/C21H16ClN3/c22-17-10-6-7-15(13-17)14-23-21-18-11-4-5-12-19(18)24-20(25-21)16-8-2-1-3-9-16/h1-13H,14H2,(H,23,24,25)
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n/an/a 800n/an/an/an/an/an/a



Biofor Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 5 from human platelets


J Med Chem 38: 3547-57 (1995)


Article DOI: 10.1021/jm00018a014
BindingDB Entry DOI: 10.7270/Q2F190CB
More data for this
Ligand-Target Pair
Thromboxane A2 Synthase (P450 TxA2)


(Homo sapiens (human))
BDBM50033302
PNG
(Benzyl-(2-pyridin-4-yl-quinazolin-4-yl)-amine | CH...)
Show SMILES C(Nc1nc(nc2ccccc12)-c1ccncc1)c1ccccc1
Show InChI InChI=1S/C20H16N4/c1-2-6-15(7-3-1)14-22-20-17-8-4-5-9-18(17)23-19(24-20)16-10-12-21-13-11-16/h1-13H,14H2,(H,22,23,24)
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n/an/a 830n/an/an/an/an/an/a



Biofor Inc.

Curated by ChEMBL


Assay Description
In vitro inhibition of Thromboxane A2 synthase in human platelet


J Med Chem 38: 3547-57 (1995)


Article DOI: 10.1021/jm00018a014
BindingDB Entry DOI: 10.7270/Q2F190CB
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50033332
PNG
(4-(2-Phenyl-quinazolin-4-ylamino)-benzoic acid met...)
Show SMILES COC(=O)c1ccc(Nc2nc(nc3ccccc23)-c2ccccc2)cc1
Show InChI InChI=1S/C22H17N3O2/c1-27-22(26)16-11-13-17(14-12-16)23-21-18-9-5-6-10-19(18)24-20(25-21)15-7-3-2-4-8-15/h2-14H,1H3,(H,23,24,25)
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n/an/a 860n/an/an/an/an/an/a



Biofor Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 5 from human platelets


J Med Chem 38: 3547-57 (1995)


Article DOI: 10.1021/jm00018a014
BindingDB Entry DOI: 10.7270/Q2F190CB
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50033310
PNG
((2-Imidazol-1-yl-quinazolin-4-yl)-phenethyl-amine;...)
Show SMILES C(Cc1ccccc1)Nc1nc(nc2ccccc12)-n1ccnc1
Show InChI InChI=1S/C19H17N5/c1-2-6-15(7-3-1)10-11-21-18-16-8-4-5-9-17(16)22-19(23-18)24-13-12-20-14-24/h1-9,12-14H,10-11H2,(H,21,22,23)
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n/an/a 860n/an/an/an/an/an/a



Biofor Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 5 from human platelets


J Med Chem 38: 3547-57 (1995)


Article DOI: 10.1021/jm00018a014
BindingDB Entry DOI: 10.7270/Q2F190CB
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50033333
PNG
((3-Chloro-phenyl)-(2-phenyl-quinazolin-4-yl)-amine...)
Show SMILES Clc1cccc(Nc2nc(nc3ccccc23)-c2ccccc2)c1
Show InChI InChI=1S/C20H14ClN3/c21-15-9-6-10-16(13-15)22-20-17-11-4-5-12-18(17)23-19(24-20)14-7-2-1-3-8-14/h1-13H,(H,22,23,24)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Biofor Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 5 from human platelets


J Med Chem 38: 3547-57 (1995)


Article DOI: 10.1021/jm00018a014
BindingDB Entry DOI: 10.7270/Q2F190CB
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50033323
PNG
(CHEMBL118376 | [2-(3-Methyl-1H-pyrrol-2-yl)-ethyl]...)
Show SMILES Cc1cc[nH]c1CCNc1nc(nc2ccccc12)-c1cccnc1
Show InChI InChI=1S/C20H19N5/c1-14-8-11-22-17(14)9-12-23-20-16-6-2-3-7-18(16)24-19(25-20)15-5-4-10-21-13-15/h2-8,10-11,13,22H,9,12H2,1H3,(H,23,24,25)
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n/an/a 1.10E+3n/an/an/an/an/an/a



Biofor Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 5 from human platelets


J Med Chem 38: 3547-57 (1995)


Article DOI: 10.1021/jm00018a014
BindingDB Entry DOI: 10.7270/Q2F190CB
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50033288
PNG
((2-Phenyl-quinazolin-4-yl)-thiophen-2-ylmethyl-ami...)
Show SMILES C(Nc1nc(nc2ccccc12)-c1ccccc1)c1cccs1
Show InChI InChI=1S/C19H15N3S/c1-2-7-14(8-3-1)18-21-17-11-5-4-10-16(17)19(22-18)20-13-15-9-6-12-23-15/h1-12H,13H2,(H,20,21,22)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Biofor Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 5 from human platelets


J Med Chem 38: 3547-57 (1995)


Article DOI: 10.1021/jm00018a014
BindingDB Entry DOI: 10.7270/Q2F190CB
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50033320
PNG
(CHEMBL118481 | Phenyl-(2-pyridin-4-yl-quinazolin-4...)
Show SMILES N(c1ccccc1)c1nc(nc2ccccc12)-c1ccncc1
Show InChI InChI=1S/C19H14N4/c1-2-6-15(7-3-1)21-19-16-8-4-5-9-17(16)22-18(23-19)14-10-12-20-13-11-14/h1-13H,(H,21,22,23)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Biofor Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 5 from human platelets


J Med Chem 38: 3547-57 (1995)


Article DOI: 10.1021/jm00018a014
BindingDB Entry DOI: 10.7270/Q2F190CB
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50033353
PNG
((3-Nitro-benzyl)-(2-phenyl-quinazolin-4-yl)-amine ...)
Show SMILES [O-][N+](=O)c1cccc(CNc2nc(nc3ccccc23)-c2ccccc2)c1
Show InChI InChI=1S/C21H16N4O2/c26-25(27)17-10-6-7-15(13-17)14-22-21-18-11-4-5-12-19(18)23-20(24-21)16-8-2-1-3-9-16/h1-13H,14H2,(H,22,23,24)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Biofor Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 5 from human platelets


J Med Chem 38: 3547-57 (1995)


Article DOI: 10.1021/jm00018a014
BindingDB Entry DOI: 10.7270/Q2F190CB
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50033350
PNG
(Benzyl-[2-((E)-styryl)-quinazolin-4-yl]-amine | CH...)
Show SMILES C(Nc1nc(\C=C\c2ccccc2)nc2ccccc12)c1ccccc1
Show InChI InChI=1S/C23H19N3/c1-3-9-18(10-4-1)15-16-22-25-21-14-8-7-13-20(21)23(26-22)24-17-19-11-5-2-6-12-19/h1-16H,17H2,(H,24,25,26)/b16-15+
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n/an/a 1.30E+3n/an/an/an/an/an/a



Biofor Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 5 from human platelets


J Med Chem 38: 3547-57 (1995)


Article DOI: 10.1021/jm00018a014
BindingDB Entry DOI: 10.7270/Q2F190CB
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM68581
PNG
(2-furfuryl-[2-(3-pyridyl)quinazolin-4-yl]amine | C...)
Show SMILES C(Nc1nc(nc2ccccc12)-c1cccnc1)c1ccco1
Show InChI InChI=1S/C18H14N4O/c1-2-8-16-15(7-1)18(20-12-14-6-4-10-23-14)22-17(21-16)13-5-3-9-19-11-13/h1-11H,12H2,(H,20,21,22)
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n/an/a 1.70E+3n/an/an/an/an/an/a



Biofor Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 5 from human platelets


J Med Chem 38: 3547-57 (1995)


Article DOI: 10.1021/jm00018a014
BindingDB Entry DOI: 10.7270/Q2F190CB
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50033314
PNG
(CHEMBL117509 | Phenethyl-(2-phenyl-quinazolin-4-yl...)
Show SMILES C(Cc1ccccc1)Nc1nc(nc2ccccc12)-c1ccccc1
Show InChI InChI=1S/C22H19N3/c1-3-9-17(10-4-1)15-16-23-22-19-13-7-8-14-20(19)24-21(25-22)18-11-5-2-6-12-18/h1-14H,15-16H2,(H,23,24,25)
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n/an/a 1.90E+3n/an/an/an/an/an/a



Biofor Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 5 from human platelets


J Med Chem 38: 3547-57 (1995)


Article DOI: 10.1021/jm00018a014
BindingDB Entry DOI: 10.7270/Q2F190CB
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50033307
PNG
((4-Chloro-phenyl)-(2-phenyl-quinazolin-4-yl)-amine...)
Show SMILES Clc1ccc(Nc2nc(nc3ccccc23)-c2ccccc2)cc1
Show InChI InChI=1S/C20H14ClN3/c21-15-10-12-16(13-11-15)22-20-17-8-4-5-9-18(17)23-19(24-20)14-6-2-1-3-7-14/h1-13H,(H,22,23,24)
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n/an/a 2.15E+3n/an/an/an/an/an/a



Biofor Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 5 from human platelets


J Med Chem 38: 3547-57 (1995)


Article DOI: 10.1021/jm00018a014
BindingDB Entry DOI: 10.7270/Q2F190CB
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM58366
PNG
(CHEMBL544584 | MLS001165148 | N-(phenylmethyl)-2-(...)
Show SMILES C(Nc1nc(nc2ccccc12)-c1ccccn1)c1ccccc1
Show InChI InChI=1S/C20H16N4/c1-2-8-15(9-3-1)14-22-19-16-10-4-5-11-17(16)23-20(24-19)18-12-6-7-13-21-18/h1-13H,14H2,(H,22,23,24)
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n/an/a 2.30E+3n/an/an/an/an/an/a



Biofor Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 5 from human platelets


J Med Chem 38: 3547-57 (1995)


Article DOI: 10.1021/jm00018a014
BindingDB Entry DOI: 10.7270/Q2F190CB
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50033308
PNG
((2-Furan-2-yl-quinazolin-4-yl)-phenyl-amine | CHEM...)
Show SMILES N(c1ccccc1)c1nc(nc2ccccc12)-c1ccco1
Show InChI InChI=1S/C18H13N3O/c1-2-7-13(8-3-1)19-17-14-9-4-5-10-15(14)20-18(21-17)16-11-6-12-22-16/h1-12H,(H,19,20,21)
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n/an/a 2.30E+3n/an/an/an/an/an/a



Biofor Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 5 from human platelets


J Med Chem 38: 3547-57 (1995)


Article DOI: 10.1021/jm00018a014
BindingDB Entry DOI: 10.7270/Q2F190CB
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50033309
PNG
(CHEMBL119506 | Cyclopentyl-(2-phenyl-quinazolin-4-...)
Show SMILES C1CCC(C1)Nc1nc(nc2ccccc12)-c1ccccc1
Show InChI InChI=1S/C19H19N3/c1-2-8-14(9-3-1)18-21-17-13-7-6-12-16(17)19(22-18)20-15-10-4-5-11-15/h1-3,6-9,12-13,15H,4-5,10-11H2,(H,20,21,22)
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n/an/a 2.40E+3n/an/an/an/an/an/a



Biofor Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 5 from human platelets


J Med Chem 38: 3547-57 (1995)


Article DOI: 10.1021/jm00018a014
BindingDB Entry DOI: 10.7270/Q2F190CB
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50033338
PNG
(CHEMBL118415 | Phenyl-(2-thiophen-2-yl-quinazolin-...)
Show SMILES N(c1ccccc1)c1nc(nc2ccccc12)-c1cccs1
Show InChI InChI=1S/C18H13N3S/c1-2-7-13(8-3-1)19-17-14-9-4-5-10-15(14)20-18(21-17)16-11-6-12-22-16/h1-12H,(H,19,20,21)
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n/an/a 2.40E+3n/an/an/an/an/an/a



Biofor Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 5 from human platelets


J Med Chem 38: 3547-57 (1995)


Article DOI: 10.1021/jm00018a014
BindingDB Entry DOI: 10.7270/Q2F190CB
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM50033316
PNG
(Benzyl-(2-furan-2-yl-quinazolin-4-yl)-amine | CHEM...)
Show SMILES C(Nc1nc(nc2ccccc12)-c1ccco1)c1ccccc1
Show InChI InChI=1S/C19H15N3O/c1-2-7-14(8-3-1)13-20-18-15-9-4-5-10-16(15)21-19(22-18)17-11-6-12-23-17/h1-12H,13H2,(H,20,21,22)
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n/an/a 2.50E+3n/an/an/an/an/an/a



Biofor Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 5 from human platelets


J Med Chem 38: 3547-57 (1995)


Article DOI: 10.1021/jm00018a014
BindingDB Entry DOI: 10.7270/Q2F190CB
More data for this
Ligand-Target Pair
Thromboxane A2 Synthase (P450 TxA2)


(Homo sapiens (human))
BDBM50033293
PNG
(Benzyl-(2-imidazol-1-yl-6-methoxy-quinazolin-4-yl)...)
Show SMILES COc1ccc2nc(nc(NCc3ccccc3)c2c1)-n1ccnc1
Show InChI InChI=1S/C19H17N5O/c1-25-15-7-8-17-16(11-15)18(21-12-14-5-3-2-4-6-14)23-19(22-17)24-10-9-20-13-24/h2-11,13H,12H2,1H3,(H,21,22,23)
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n/an/a 2.50E+3n/an/an/an/an/an/a



Biofor Inc.

Curated by ChEMBL


Assay Description
In vitro inhibition of Thromboxane A2 synthase in human platelet


J Med Chem 38: 3547-57 (1995)


Article DOI: 10.1021/jm00018a014
BindingDB Entry DOI: 10.7270/Q2F190CB
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM14363
PNG
(3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...)
Show SMILES CCCOc1ccccc1-c1nc2nn[nH]c2c(=O)[nH]1
Show InChI InChI=1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19)
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n/an/a 2.70E+3n/an/an/an/an/an/a



Biofor Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 5 from human platelets


J Med Chem 38: 3547-57 (1995)


Article DOI: 10.1021/jm00018a014
BindingDB Entry DOI: 10.7270/Q2F190CB
More data for this
Ligand-Target Pair
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