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Compile Data Set for Download or QSAR

Found 81 hits from Boehringer Ingelheim International GmbH   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126914
PNG
(US8785464, 73)
Show SMILES COc1cc(ccc1Nc1ncc(c(Oc2ccccc2NS(C)(=O)=O)n1)C(F)(F)F)C(=O)NC1CCN(C)CC1
Show InChI InChI=1S/C26H29F3N6O5S/c1-35-12-10-17(11-13-35)31-23(36)16-8-9-19(22(14-16)39-2)32-25-30-15-18(26(27,28)29)24(33-25)40-21-7-5-4-6-20(21)34-41(3,37)38/h4-9,14-15,17,34H,10-13H2,1-3H3,(H,31,36)(H,30,32,33)
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n/an/a 3n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126922
PNG
(US8785464, 81)
Show SMILES COc1cc(ccc1Nc1ncc(c(Oc2cc(F)ccc2NS(C)(=O)=O)n1)C(F)(F)F)C(=O)NC1CCN(C)CC1
Show InChI InChI=1S/C26H28F4N6O5S/c1-36-10-8-17(9-11-36)32-23(37)15-4-6-19(21(12-15)40-2)33-25-31-14-18(26(28,29)30)24(34-25)41-22-13-16(27)5-7-20(22)35-42(3,38)39/h4-7,12-14,17,35H,8-11H2,1-3H3,(H,32,37)(H,31,33,34)
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n/an/a 4n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126889
PNG
(US8785464, 48)
Show SMILES COc1cc(ccc1Nc1ncc(c(Oc2ccccc2C#N)n1)C(F)(F)F)C(=O)NC1CCN(C)CC1
Show InChI InChI=1S/C26H25F3N6O3/c1-35-11-9-18(10-12-35)32-23(36)16-7-8-20(22(13-16)37-2)33-25-31-15-19(26(27,28)29)24(34-25)38-21-6-4-3-5-17(21)14-30/h3-8,13,15,18H,9-12H2,1-2H3,(H,32,36)(H,31,33,34)
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n/an/a 6n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126920
PNG
(US8785464, 79)
Show SMILES COc1cc(ccc1Nc1ncc(c(Oc2c(Cl)cccc2NS(C)(=O)=O)n1)C(F)(F)F)C(=O)NC1CCN(C)CC1
Show InChI InChI=1S/C26H28ClF3N6O5S/c1-36-11-9-16(10-12-36)32-23(37)15-7-8-19(21(13-15)40-2)33-25-31-14-17(26(28,29)30)24(34-25)41-22-18(27)5-4-6-20(22)35-42(3,38)39/h4-8,13-14,16,35H,9-12H2,1-3H3,(H,32,37)(H,31,33,34)
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n/an/a 6n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126890
PNG
(US8785464, 49)
Show SMILES COc1cc(C(=O)NC2CCN(C)CC2)c(F)cc1Nc1ncc(c(Oc2ccccc2C#N)n1)C(F)(F)F
Show InChI InChI=1S/C26H24F4N6O3/c1-36-9-7-16(8-10-36)33-23(37)17-11-22(38-2)20(12-19(17)27)34-25-32-14-18(26(28,29)30)24(35-25)39-21-6-4-3-5-15(21)13-31/h3-6,11-12,14,16H,7-10H2,1-2H3,(H,33,37)(H,32,34,35)
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n/an/a 7n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126883
PNG
(US8785464, 42)
Show SMILES COc1cc(ccc1Nc1ncc(c(Oc2cccc(Cl)c2C#N)n1)C(F)(F)F)C(=O)NC1CCN(C)CC1
Show InChI InChI=1S/C26H24ClF3N6O3/c1-36-10-8-16(9-11-36)33-23(37)15-6-7-20(22(12-15)38-2)34-25-32-14-18(26(28,29)30)24(35-25)39-21-5-3-4-19(27)17(21)13-31/h3-7,12,14,16H,8-11H2,1-2H3,(H,33,37)(H,32,34,35)
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n/an/a 8n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126852
PNG
(US8785464, 11)
Show SMILES COC(=O)c1ccccc1Oc1nc(Nc2ccc(cc2OC)C(=O)NC2CCN(C)CC2)ncc1C(F)(F)F
Show InChI InChI=1S/C27H28F3N5O5/c1-35-12-10-17(11-13-35)32-23(36)16-8-9-20(22(14-16)38-2)33-26-31-15-19(27(28,29)30)24(34-26)40-21-7-5-4-6-18(21)25(37)39-3/h4-9,14-15,17H,10-13H2,1-3H3,(H,32,36)(H,31,33,34)
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n/an/a 8n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126911
PNG
(US8785464, 70)
Show SMILES COc1cc(C(=O)NC2CCN(C)CC2)c(F)cc1Nc1ncc(c(Oc2cccc(C)c2C#N)n1)C(F)(F)F
Show InChI InChI=1S/C27H26F4N6O3/c1-15-5-4-6-22(18(15)13-32)40-25-19(27(29,30)31)14-33-26(36-25)35-21-12-20(28)17(11-23(21)39-3)24(38)34-16-7-9-37(2)10-8-16/h4-6,11-12,14,16H,7-10H2,1-3H3,(H,34,38)(H,33,35,36)
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n/an/a 9n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126921
PNG
(US8785464, 80)
Show SMILES COc1cc(ccc1Nc1ncc(c(Oc2ccc(Cl)cc2NS(C)(=O)=O)n1)C(F)(F)F)C(=O)NC1CCN(C)CC1
Show InChI InChI=1S/C26H28ClF3N6O5S/c1-36-10-8-17(9-11-36)32-23(37)15-4-6-19(22(12-15)40-2)33-25-31-14-18(26(28,29)30)24(34-25)41-21-7-5-16(27)13-20(21)35-42(3,38)39/h4-7,12-14,17,35H,8-11H2,1-3H3,(H,32,37)(H,31,33,34)
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n/an/a 10n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126916
PNG
(US8785464, 75)
Show SMILES COc1cc(ccc1Nc1ncc(c(Oc2ccccc2N(C)S(C)(=O)=O)n1)C(F)(F)F)C(=O)NC1CCN(C)CC1
Show InChI InChI=1S/C27H31F3N6O5S/c1-35-13-11-18(12-14-35)32-24(37)17-9-10-20(23(15-17)40-3)33-26-31-16-19(27(28,29)30)25(34-26)41-22-8-6-5-7-21(22)36(2)42(4,38)39/h5-10,15-16,18H,11-14H2,1-4H3,(H,32,37)(H,31,33,34)
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n/an/a 10n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126846
PNG
(US8785464, 5)
Show SMILES COC(=O)c1ccccc1Oc1nc(Nc2cc(F)c(cc2OC)C(=O)NC2CCN(C)CC2)ncc1C(F)(F)F
Show InChI InChI=1S/C27H27F4N5O5/c1-36-10-8-15(9-11-36)33-23(37)17-12-22(39-2)20(13-19(17)28)34-26-32-14-18(27(29,30)31)24(35-26)41-21-7-5-4-6-16(21)25(38)40-3/h4-7,12-15H,8-11H2,1-3H3,(H,33,37)(H,32,34,35)
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n/an/a 11n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126880
PNG
(US8785464, 39)
Show SMILES COc1cc(ccc1Nc1ncc(c(Oc2ccccc2-c2csnn2)n1)C(F)(F)F)C(=O)NC1CCN(C)CC1
Show InChI InChI=1S/C27H26F3N7O3S/c1-37-11-9-17(10-12-37)32-24(38)16-7-8-20(23(13-16)39-2)33-26-31-14-19(27(28,29)30)25(34-26)40-22-6-4-3-5-18(22)21-15-41-36-35-21/h3-8,13-15,17H,9-12H2,1-2H3,(H,32,38)(H,31,33,34)
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n/an/a 12n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126918
PNG
(US8785464, 77)
Show SMILES COc1cc(C(=O)NC2CCN(C)CC2)c(F)cc1Nc1ncc(c(Oc2ccccc2N(C)S(C)(=O)=O)n1)C(F)(F)F
Show InChI InChI=1S/C27H30F4N6O5S/c1-36-11-9-16(10-12-36)33-24(38)17-13-23(41-3)20(14-19(17)28)34-26-32-15-18(27(29,30)31)25(35-26)42-22-8-6-5-7-21(22)37(2)43(4,39)40/h5-8,13-16H,9-12H2,1-4H3,(H,33,38)(H,32,34,35)
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n/an/a 12n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126923
PNG
(US8785464, 82)
Show SMILES COc1cc(ccc1Nc1ncc(c(Oc2cc(C)ccc2NS(C)(=O)=O)n1)C(F)(F)F)C(=O)NC1CCN(C)CC1
Show InChI InChI=1S/C27H31F3N6O5S/c1-16-5-7-21(35-42(4,38)39)23(13-16)41-25-19(27(28,29)30)15-31-26(34-25)33-20-8-6-17(14-22(20)40-3)24(37)32-18-9-11-36(2)12-10-18/h5-8,13-15,18,35H,9-12H2,1-4H3,(H,32,37)(H,31,33,34)
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n/an/a 12n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126899
PNG
(US8785464, 58)
Show SMILES COc1cc(ccc1Nc1ncc(c(OCC2CCCO2)n1)C(F)(F)F)C(=O)NC1CCN(C)CC1
Show InChI InChI=1S/C24H30F3N5O4/c1-32-9-7-16(8-10-32)29-21(33)15-5-6-19(20(12-15)34-2)30-23-28-13-18(24(25,26)27)22(31-23)36-14-17-4-3-11-35-17/h5-6,12-13,16-17H,3-4,7-11,14H2,1-2H3,(H,29,33)(H,28,30,31)
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n/an/a 15n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126897
PNG
(US8785464, 56)
Show SMILES COc1cccc(COc2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2C(F)(F)F)c1
Show InChI InChI=1S/C27H30F3N5O4/c1-35-11-9-19(10-12-35)32-24(36)18-7-8-22(23(14-18)38-3)33-26-31-15-21(27(28,29)30)25(34-26)39-16-17-5-4-6-20(13-17)37-2/h4-8,13-15,19H,9-12,16H2,1-3H3,(H,32,36)(H,31,33,34)
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n/an/a 16n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126854
PNG
(US8785464, 13 | US8785464, 27)
Show SMILES COc1cc(ccc1Nc1ncc(c(Oc2cccc(CC(N)=O)c2)n1)C(F)(F)F)C(=O)NC1CCN(C)CC1
Show InChI InChI=1S/C27H29F3N6O4/c1-36-10-8-18(9-11-36)33-24(38)17-6-7-21(22(14-17)39-2)34-26-32-15-20(27(28,29)30)25(35-26)40-19-5-3-4-16(12-19)13-23(31)37/h3-7,12,14-15,18H,8-11,13H2,1-2H3,(H2,31,37)(H,33,38)(H,32,34,35)
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n/an/a 17n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126909
PNG
(US8785464, 68)
Show SMILES COc1cc(ccc1Nc1ncc(c(Oc2ccccc2-c2ccon2)n1)C(F)(F)F)C(=O)NC1CCN(C)CC1
Show InChI InChI=1S/C28H27F3N6O4/c1-37-12-9-18(10-13-37)33-25(38)17-7-8-22(24(15-17)39-2)34-27-32-16-20(28(29,30)31)26(35-27)41-23-6-4-3-5-19(23)21-11-14-40-36-21/h3-8,11,14-16,18H,9-10,12-13H2,1-2H3,(H,33,38)(H,32,34,35)
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US Patent
n/an/a 19n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126863
PNG
(US8785464, 22)
Show SMILES COc1cc(ccc1Nc1ncc(c(Oc2cccc3nc[nH]c23)n1)C(F)(F)F)C(=O)NC1CCN(C)CC1
Show InChI InChI=1S/C26H26F3N7O3/c1-36-10-8-16(9-11-36)33-23(37)15-6-7-18(21(12-15)38-2)34-25-30-13-17(26(27,28)29)24(35-25)39-20-5-3-4-19-22(20)32-14-31-19/h3-7,12-14,16H,8-11H2,1-2H3,(H,31,32)(H,33,37)(H,30,34,35)
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US Patent
n/an/a 19n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126886
PNG
(US8785464, 45)
Show SMILES COc1cc(ccc1Nc1ncc(c(Oc2ccc(Cl)cc2C#N)n1)C(F)(F)F)C(=O)NC1CCN(C)CC1
Show InChI InChI=1S/C26H24ClF3N6O3/c1-36-9-7-18(8-10-36)33-23(37)15-3-5-20(22(12-15)38-2)34-25-32-14-19(26(28,29)30)24(35-25)39-21-6-4-17(27)11-16(21)13-31/h3-6,11-12,14,18H,7-10H2,1-2H3,(H,33,37)(H,32,34,35)
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n/an/a 20n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126853
PNG
(US8785464, 12 | US8785464, 24)
Show SMILES COc1cc(ccc1Nc1ncc(c(Oc2cccc(c2)C(N)=O)n1)C(F)(F)F)C(=O)NC1CCN(C)CC1
Show InChI InChI=1S/C26H27F3N6O4/c1-35-10-8-17(9-11-35)32-23(37)16-6-7-20(21(13-16)38-2)33-25-31-14-19(26(27,28)29)24(34-25)39-18-5-3-4-15(12-18)22(30)36/h3-7,12-14,17H,8-11H2,1-2H3,(H2,30,36)(H,32,37)(H,31,33,34)
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n/an/a 25n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126853
PNG
(US8785464, 12 | US8785464, 24)
Show SMILES COc1cc(ccc1Nc1ncc(c(Oc2cccc(c2)C(N)=O)n1)C(F)(F)F)C(=O)NC1CCN(C)CC1
Show InChI InChI=1S/C26H27F3N6O4/c1-35-10-8-17(9-11-35)32-23(37)16-6-7-20(21(13-16)38-2)33-25-31-14-19(26(27,28)29)24(34-25)39-18-5-3-4-15(12-18)22(30)36/h3-7,12-14,17H,8-11H2,1-2H3,(H2,30,36)(H,32,37)(H,31,33,34)
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n/an/a 25n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126917
PNG
(US8785464, 76)
Show SMILES CCN(c1ccccc1Oc1nc(Nc2ccc(cc2OC)C(=O)NC2CCN(C)CC2)ncc1C(F)(F)F)S(C)(=O)=O
Show InChI InChI=1S/C28H33F3N6O5S/c1-5-37(43(4,39)40)22-8-6-7-9-23(22)42-26-20(28(29,30)31)17-32-27(35-26)34-21-11-10-18(16-24(21)41-3)25(38)33-19-12-14-36(2)15-13-19/h6-11,16-17,19H,5,12-15H2,1-4H3,(H,33,38)(H,32,34,35)
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n/an/a 27n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126849
PNG
(US8785464, 8)
Show SMILES COc1cc(ccc1Nc1ncc(c(Oc2ccc(cc2)C(N)=O)n1)C(F)(F)F)C(=O)NC1CCN(C)CC1
Show InChI InChI=1S/C26H27F3N6O4/c1-35-11-9-17(10-12-35)32-23(37)16-5-8-20(21(13-16)38-2)33-25-31-14-19(26(27,28)29)24(34-25)39-18-6-3-15(4-7-18)22(30)36/h3-8,13-14,17H,9-12H2,1-2H3,(H2,30,36)(H,32,37)(H,31,33,34)
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n/an/a 30n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126882
PNG
(US8785464, 41)
Show SMILES COc1cc(ccc1Nc1ncc(c(Oc2cc(Br)ccc2C#N)n1)C(F)(F)F)C(=O)NC1CCN(C)CC1
Show InChI InChI=1S/C26H24BrF3N6O3/c1-36-9-7-18(8-10-36)33-23(37)15-4-6-20(22(11-15)38-2)34-25-32-14-19(26(28,29)30)24(35-25)39-21-12-17(27)5-3-16(21)13-31/h3-6,11-12,14,18H,7-10H2,1-2H3,(H,33,37)(H,32,34,35)
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n/an/a 30n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126881
PNG
(US8785464, 40)
Show SMILES COc1cc(ccc1Nc1ncc(c(Oc2ccc(Br)cc2C#N)n1)C(F)(F)F)C(=O)NC1CCN(C)CC1
Show InChI InChI=1S/C26H24BrF3N6O3/c1-36-9-7-18(8-10-36)33-23(37)15-3-5-20(22(12-15)38-2)34-25-32-14-19(26(28,29)30)24(35-25)39-21-6-4-17(27)11-16(21)13-31/h3-6,11-12,14,18H,7-10H2,1-2H3,(H,33,37)(H,32,34,35)
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n/an/a 30n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126884
PNG
(US8785464, 43)
Show SMILES COc1cc(ccc1Nc1ncc(c(Oc2cccc(F)c2C#N)n1)C(F)(F)F)C(=O)NC1CCN(C)CC1
Show InChI InChI=1S/C26H24F4N6O3/c1-36-10-8-16(9-11-36)33-23(37)15-6-7-20(22(12-15)38-2)34-25-32-14-18(26(28,29)30)24(35-25)39-21-5-3-4-19(27)17(21)13-31/h3-7,12,14,16H,8-11H2,1-2H3,(H,33,37)(H,32,34,35)
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n/an/a 31n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126903
PNG
(US8785464, 62)
Show SMILES COc1cc(ccc1Nc1ncc(c(OCc2cccc(OC)c2OC)n1)C(F)(F)F)C(=O)NC1CCN(C)CC1
Show InChI InChI=1S/C28H32F3N5O5/c1-36-12-10-19(11-13-36)33-25(37)17-8-9-21(23(14-17)39-3)34-27-32-15-20(28(29,30)31)26(35-27)41-16-18-6-5-7-22(38-2)24(18)40-4/h5-9,14-15,19H,10-13,16H2,1-4H3,(H,33,37)(H,32,34,35)
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n/an/a 36n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126869
PNG
(US8785464, 28)
Show SMILES CNC(=O)Cc1cccc(Oc2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2C(F)(F)F)c1
Show InChI InChI=1S/C28H31F3N6O4/c1-32-24(38)14-17-5-4-6-20(13-17)41-26-21(28(29,30)31)16-33-27(36-26)35-22-8-7-18(15-23(22)40-3)25(39)34-19-9-11-37(2)12-10-19/h4-8,13,15-16,19H,9-12,14H2,1-3H3,(H,32,38)(H,34,39)(H,33,35,36)
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n/an/a 36n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126873
PNG
(US8785464, 32)
Show SMILES COc1cc(ccc1Nc1ncc(c(Oc2ccc(CC(=O)N(C)C)cc2)n1)C(F)(F)F)C(=O)NC1CCN(C)CC1
Show InChI InChI=1S/C29H33F3N6O4/c1-37(2)25(39)15-18-5-8-21(9-6-18)42-27-22(29(30,31)32)17-33-28(36-27)35-23-10-7-19(16-24(23)41-4)26(40)34-20-11-13-38(3)14-12-20/h5-10,16-17,20H,11-15H2,1-4H3,(H,34,40)(H,33,35,36)
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n/an/a 36n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126864
PNG
(US8785464, 23)
Show SMILES COc1cc(ccc1Nc1ncc(c(Oc2ccc3[nH]cnc3c2)n1)C(F)(F)F)C(=O)NC1CCN(C)CC1
Show InChI InChI=1S/C26H27F3N7O3/c1-36-9-7-16(8-10-36)33-23(37)15-3-5-20(22(11-15)38-2)34-25-30-13-18(26(27,28)29)24(35-25)39-17-4-6-19-21(12-17)32-14-31-19/h3-6,11-14,16,31-32H,7-10H2,1-2H3,(H,33,37)(H,30,34,35)
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n/an/a 38n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126919
PNG
(US8785464, 78)
Show SMILES CCN(c1ccccc1Oc1nc(Nc2cc(F)c(cc2OC)C(=O)NC2CCN(C)CC2)ncc1C(F)(F)F)S(C)(=O)=O
Show InChI InChI=1S/C28H32F4N6O5S/c1-5-38(44(4,40)41)22-8-6-7-9-23(22)43-26-19(28(30,31)32)16-33-27(36-26)35-21-15-20(29)18(14-24(21)42-3)25(39)34-17-10-12-37(2)13-11-17/h6-9,14-17H,5,10-13H2,1-4H3,(H,34,39)(H,33,35,36)
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n/an/a 38n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126871
PNG
(US8785464, 30)
Show SMILES COc1cc(ccc1Nc1ncc(c(Oc2ccc(CC(N)=O)cc2)n1)C(F)(F)F)C(=O)NC1CCN(C)CC1
Show InChI InChI=1S/C27H29F3N6O4/c1-36-11-9-18(10-12-36)33-24(38)17-5-8-21(22(14-17)39-2)34-26-32-15-20(27(28,29)30)25(35-26)40-19-6-3-16(4-7-19)13-23(31)37/h3-8,14-15,18H,9-13H2,1-2H3,(H2,31,37)(H,33,38)(H,32,34,35)
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n/an/a 39n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126898
PNG
(US8785464, 57)
Show SMILES COc1cc(ccc1Nc1ncc(c(OCCN2CCCC2=O)n1)C(F)(F)F)C(=O)NC1CCN(C)CC1
Show InChI InChI=1S/C25H31F3N6O4/c1-33-10-7-17(8-11-33)30-22(36)16-5-6-19(20(14-16)37-2)31-24-29-15-18(25(26,27)28)23(32-24)38-13-12-34-9-3-4-21(34)35/h5-6,14-15,17H,3-4,7-13H2,1-2H3,(H,30,36)(H,29,31,32)
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n/an/a 39n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126904
PNG
(US8785464, 63)
Show SMILES COc1cc(ccc1Nc1ncc(c(OCC2CCCCO2)n1)C(F)(F)F)C(=O)NC1CCN(C)CC1
Show InChI InChI=1S/C25H32F3N5O4/c1-33-10-8-17(9-11-33)30-22(34)16-6-7-20(21(13-16)35-2)31-24-29-14-19(25(26,27)28)23(32-24)37-15-18-5-3-4-12-36-18/h6-7,13-14,17-18H,3-5,8-12,15H2,1-2H3,(H,30,34)(H,29,31,32)
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US Patent
n/an/a 40n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126870
PNG
(US8785464, 29)
Show SMILES COc1cc(ccc1Nc1ncc(c(Oc2cccc(CC(=O)N(C)C)c2)n1)C(F)(F)F)C(=O)NC1CCN(C)CC1
Show InChI InChI=1S/C29H33F3N6O4/c1-37(2)25(39)15-18-6-5-7-21(14-18)42-27-22(29(30,31)32)17-33-28(36-27)35-23-9-8-19(16-24(23)41-4)26(40)34-20-10-12-38(3)13-11-20/h5-9,14,16-17,20H,10-13,15H2,1-4H3,(H,34,40)(H,33,35,36)
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US Patent
n/an/a 41n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126862
PNG
(US8785464, 21)
Show SMILES COc1cc(ccc1Nc1ncc(c(Oc2cccc3[nH]ccc23)n1)C(F)(F)F)C(=O)NC1CCN(C)CC1
Show InChI InChI=1S/C27H27F3N6O3/c1-36-12-9-17(10-13-36)33-24(37)16-6-7-21(23(14-16)38-2)34-26-32-15-19(27(28,29)30)25(35-26)39-22-5-3-4-20-18(22)8-11-31-20/h3-8,11,14-15,17,31H,9-10,12-13H2,1-2H3,(H,33,37)(H,32,34,35)
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n/an/a 43n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126850
PNG
(US8785464, 9)
Show SMILES COc1cc(ccc1Nc1ncc(c(Oc2cccc(c2)C(C)=O)n1)C(F)(F)F)C(=O)NC1CCN(C)CC1
Show InChI InChI=1S/C27H28F3N5O4/c1-16(36)17-5-4-6-20(13-17)39-25-21(27(28,29)30)15-31-26(34-25)33-22-8-7-18(14-23(22)38-3)24(37)32-19-9-11-35(2)12-10-19/h4-8,13-15,19H,9-12H2,1-3H3,(H,32,37)(H,31,33,34)
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n/an/a 47n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126885
PNG
(US8785464, 44)
Show SMILES COc1ccc(C#N)c(Oc2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2C(F)(F)F)c1
Show InChI InChI=1S/C27H27F3N6O4/c1-36-10-8-18(9-11-36)33-24(37)16-5-7-21(23(12-16)39-3)34-26-32-15-20(27(28,29)30)25(35-26)40-22-13-19(38-2)6-4-17(22)14-31/h4-7,12-13,15,18H,8-11H2,1-3H3,(H,33,37)(H,32,34,35)
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n/an/a 47n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126845
PNG
(US8785464, 4)
Show SMILES COc1cc(C(=O)NC2CCN(C)CC2)c(F)cc1Nc1ncc(c(Oc2ccccc2)n1)C(F)(F)F
Show InChI InChI=1S/C25H25F4N5O3/c1-34-10-8-15(9-11-34)31-22(35)17-12-21(36-2)20(13-19(17)26)32-24-30-14-18(25(27,28)29)23(33-24)37-16-6-4-3-5-7-16/h3-7,12-15H,8-11H2,1-2H3,(H,31,35)(H,30,32,33)
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n/an/a 48n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126872
PNG
(US8785464, 31)
Show SMILES CNC(=O)Cc1ccc(Oc2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2C(F)(F)F)cc1
Show InChI InChI=1S/C28H31F3N6O4/c1-32-24(38)14-17-4-7-20(8-5-17)41-26-21(28(29,30)31)16-33-27(36-26)35-22-9-6-18(15-23(22)40-3)25(39)34-19-10-12-37(2)13-11-19/h4-9,15-16,19H,10-14H2,1-3H3,(H,32,38)(H,34,39)(H,33,35,36)
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n/an/a 49n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126847
PNG
(US8785464, 6)
Show SMILES COc1cc(C(=O)NC2CCN(C)CC2)c(F)cc1Nc1ncc(c(Oc2ccccc2C(N)=O)n1)C(F)(F)F
Show InChI InChI=1S/C26H26F4N6O4/c1-36-9-7-14(8-10-36)33-23(38)16-11-21(39-2)19(12-18(16)27)34-25-32-13-17(26(28,29)30)24(35-25)40-20-6-4-3-5-15(20)22(31)37/h3-6,11-14H,7-10H2,1-2H3,(H2,31,37)(H,33,38)(H,32,34,35)
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n/an/a 52n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126900
PNG
(US8785464, 59)
Show SMILES COc1cc(ccc1Nc1ncc(c(OCC2CCCCN2C)n1)C(F)(F)F)C(=O)NC1CCN(C)CC1
Show InChI InChI=1S/C26H35F3N6O3/c1-34-12-9-18(10-13-34)31-23(36)17-7-8-21(22(14-17)37-3)32-25-30-15-20(26(27,28)29)24(33-25)38-16-19-6-4-5-11-35(19)2/h7-8,14-15,18-19H,4-6,9-13,16H2,1-3H3,(H,31,36)(H,30,32,33)
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n/an/a 56n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126877
PNG
(US8785464, 36)
Show SMILES COc1cc(ccc1Nc1ncc(c(Oc2ccccc2C(C)=O)n1)C(F)(F)F)C(=O)NC1CCN(C)CC1
Show InChI InChI=1S/C27H28F3N5O4/c1-16(36)19-6-4-5-7-22(19)39-25-20(27(28,29)30)15-31-26(34-25)33-21-9-8-17(14-23(21)38-3)24(37)32-18-10-12-35(2)13-11-18/h4-9,14-15,18H,10-13H2,1-3H3,(H,32,37)(H,31,33,34)
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n/an/a 58n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126906
PNG
(US8785464, 65)
Show SMILES COC(=O)COc1nc(Nc2ccc(cc2OC)C(=O)NC2CCN(C)CC2)ncc1C(F)(F)F
Show InChI InChI=1S/C22H26F3N5O5/c1-30-8-6-14(7-9-30)27-19(32)13-4-5-16(17(10-13)33-2)28-21-26-11-15(22(23,24)25)20(29-21)35-12-18(31)34-3/h4-5,10-11,14H,6-9,12H2,1-3H3,(H,27,32)(H,26,28,29)
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n/an/a 61n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126875
PNG
(US8785464, 34)
Show SMILES CNC(=O)c1ccc(Oc2nc(Nc3ccc(cc3OC)C(=O)NC3CCN(C)CC3)ncc2C(F)(F)F)cc1
Show InChI InChI=1S/C27H29F3N6O4/c1-31-23(37)16-4-7-19(8-5-16)40-25-20(27(28,29)30)15-32-26(35-25)34-21-9-6-17(14-22(21)39-3)24(38)33-18-10-12-36(2)13-11-18/h4-9,14-15,18H,10-13H2,1-3H3,(H,31,37)(H,33,38)(H,32,34,35)
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n/an/a 62n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126856
PNG
(US8785464, 15)
Show SMILES COc1cc(ccc1Nc1ncc(c(Oc2cccc(Cl)c2)n1)C(F)(F)F)C(=O)NC1CCN(C)CC1
Show InChI InChI=1S/C25H25ClF3N5O3/c1-34-10-8-17(9-11-34)31-22(35)15-6-7-20(21(12-15)36-2)32-24-30-14-19(25(27,28)29)23(33-24)37-18-5-3-4-16(26)13-18/h3-7,12-14,17H,8-11H2,1-2H3,(H,31,35)(H,30,32,33)
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n/an/a 64n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126851
PNG
(US8785464, 10)
Show SMILES COc1cc(ccc1Nc1ncc(c(Oc2cccnc2)n1)C(F)(F)F)C(=O)NC1CCN(C)CC1
Show InChI InChI=1S/C24H25F3N6O3/c1-33-10-7-16(8-11-33)30-21(34)15-5-6-19(20(12-15)35-2)31-23-29-14-18(24(25,26)27)22(32-23)36-17-4-3-9-28-13-17/h3-6,9,12-14,16H,7-8,10-11H2,1-2H3,(H,30,34)(H,29,31,32)
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n/an/a 64n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126891
PNG
(US8785464, 50)
Show SMILES COc1cc(ccc1Nc1ncc(c(Sc2ccccc2)n1)C(F)(F)F)C(=O)NC1CCN(C)CC1
Show InChI InChI=1S/C25H26F3N5O2S/c1-33-12-10-17(11-13-33)30-22(34)16-8-9-20(21(14-16)35-2)31-24-29-15-19(25(26,27)28)23(32-24)36-18-6-4-3-5-7-18/h3-9,14-15,17H,10-13H2,1-2H3,(H,30,34)(H,29,31,32)
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n/an/a 64n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM126876
PNG
(US8785464, 35)
Show SMILES COc1cc(ccc1Nc1ncc(c(Oc2ccc(cc2)C(=O)N(C)C)n1)C(F)(F)F)C(=O)NC1CCN(C)CC1
Show InChI InChI=1S/C28H31F3N6O4/c1-36(2)26(39)17-5-8-20(9-6-17)41-25-21(28(29,30)31)16-32-27(35-25)34-22-10-7-18(15-23(22)40-4)24(38)33-19-11-13-37(3)14-12-19/h5-10,15-16,19H,11-14H2,1-4H3,(H,33,38)(H,32,34,35)
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n/an/a 65n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This test uses active PTK2 enzyme (Invitrogen Code PV3832) and poly-Glu-Tyr (4:1, Sigma P-0275) as the kinase substrate. The kinase activity is detec...


US Patent US8785464 (2014)


BindingDB Entry DOI: 10.7270/Q2R2102D
More data for this
Ligand-Target Pair
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