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Compile Data Set for Download or QSAR

Found 102 hits from Boehringer Ingelheim Pharma GmbH&Co KG   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM50279238
PNG
((Z)-3-({4-[N-Acetyl-(3-dimethylaminopropyl)-amino]...)
Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(CCCN(C)C)C(C)=O)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C30H32N4O4/c1-20(35)34(18-8-17-33(2)3)24-14-12-23(13-15-24)31-28(21-9-6-5-7-10-21)27-25-16-11-22(30(37)38-4)19-26(25)32-29(27)36/h5-7,9-16,19,27H,8,17-18H2,1-4H3,(H,32,36)
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n/an/a 3n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH&Co KG

Curated by ChEMBL


Assay Description
Inhibition of human VEGFR3


J Med Chem 52: 4466-80 (2009)


Article DOI: 10.1021/jm900431g
BindingDB Entry DOI: 10.7270/Q2RB75JS
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM50279080
PNG
((Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acety...)
Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,28H,15-18,20H2,1-3H3,(H,33,38)
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n/an/a 5n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH&Co KG

Curated by ChEMBL


Assay Description
Inhibition of human VEGFR3


J Med Chem 52: 4466-80 (2009)


Article DOI: 10.1021/jm900431g
BindingDB Entry DOI: 10.7270/Q2RB75JS
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM50279267
PNG
((Z)-3-({4-[N-Acetyl-(2-dimethylaminoethyl)-amino]-...)
Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(CCN(C)C)C(C)=O)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C29H30N4O4/c1-19(34)33(17-16-32(2)3)23-13-11-22(12-14-23)30-27(20-8-6-5-7-9-20)26-24-15-10-21(29(36)37-4)18-25(24)31-28(26)35/h5-15,18,26H,16-17H2,1-4H3,(H,31,35)
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n/an/a 5n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH&Co KG

Curated by ChEMBL


Assay Description
Inhibition of human VEGFR3


J Med Chem 52: 4466-80 (2009)


Article DOI: 10.1021/jm900431g
BindingDB Entry DOI: 10.7270/Q2RB75JS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50279080
PNG
((Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acety...)
Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,28H,15-18,20H2,1-3H3,(H,33,38)
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n/an/a 5n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH&Co KG

Curated by ChEMBL


Assay Description
Inhibition of human VEGFR2 expressed in Sf9 cells


J Med Chem 52: 4466-80 (2009)


Article DOI: 10.1021/jm900431g
BindingDB Entry DOI: 10.7270/Q2RB75JS
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM50279237
PNG
((Z)-3-{[4-(N-Acetyl-dimethylcarbamoylmethyl-amino)...)
Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(CC(=O)N(C)C)C(C)=O)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C29H28N4O5/c1-18(34)33(17-25(35)32(2)3)22-13-11-21(12-14-22)30-27(19-8-6-5-7-9-19)26-23-15-10-20(29(37)38-4)16-24(23)31-28(26)36/h5-16,26H,17H2,1-4H3,(H,31,36)
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n/an/a 6n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH&Co KG

Curated by ChEMBL


Assay Description
Inhibition of human VEGFR3


J Med Chem 52: 4466-80 (2009)


Article DOI: 10.1021/jm900431g
BindingDB Entry DOI: 10.7270/Q2RB75JS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50279236
PNG
((Z)-3-({4-[(2-Imidazol-1-yl-acetyl)methylamino]-ph...)
Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(C)C(=O)Cn3ccnc3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C29H25N5O4/c1-33(25(35)17-34-15-14-30-18-34)22-11-9-21(10-12-22)31-27(19-6-4-3-5-7-19)26-23-13-8-20(29(37)38-2)16-24(23)32-28(26)36/h3-16,18,26H,17H2,1-2H3,(H,32,36)
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n/an/a 6n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH&Co KG

Curated by ChEMBL


Assay Description
Inhibition of human VEGFR2 expressed in Sf9 cells


J Med Chem 52: 4466-80 (2009)


Article DOI: 10.1021/jm900431g
BindingDB Entry DOI: 10.7270/Q2RB75JS
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Homo sapiens (Human))
BDBM50279238
PNG
((Z)-3-({4-[N-Acetyl-(3-dimethylaminopropyl)-amino]...)
Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(CCCN(C)C)C(C)=O)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C30H32N4O4/c1-20(35)34(18-8-17-33(2)3)24-14-12-23(13-15-24)31-28(21-9-6-5-7-10-21)27-25-16-11-22(30(37)38-4)19-26(25)32-29(27)36/h5-7,9-16,19,27H,8,17-18H2,1-4H3,(H,32,36)
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n/an/a 7n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH&Co KG

Curated by ChEMBL


Assay Description
Inhibition of human PDGFRalpha


J Med Chem 52: 4466-80 (2009)


Article DOI: 10.1021/jm900431g
BindingDB Entry DOI: 10.7270/Q2RB75JS
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM50279236
PNG
((Z)-3-({4-[(2-Imidazol-1-yl-acetyl)methylamino]-ph...)
Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(C)C(=O)Cn3ccnc3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C29H25N5O4/c1-33(25(35)17-34-15-14-30-18-34)22-11-9-21(10-12-22)31-27(19-6-4-3-5-7-19)26-23-13-8-20(29(37)38-2)16-24(23)32-28(26)36/h3-16,18,26H,17H2,1-2H3,(H,32,36)
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n/an/a 7n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH&Co KG

Curated by ChEMBL


Assay Description
Inhibition of human VEGFR3


J Med Chem 52: 4466-80 (2009)


Article DOI: 10.1021/jm900431g
BindingDB Entry DOI: 10.7270/Q2RB75JS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50279082
PNG
((Z)-6-Nitro-3-[phenyl-(4-piperidin-1-ylmethyl-phen...)
Show SMILES [O-][N+](=O)c1ccc2C(C(=Nc3ccc(CN4CCCCC4)cc3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C27H26N4O3/c32-27-25(23-14-13-22(31(33)34)17-24(23)29-27)26(20-7-3-1-4-8-20)28-21-11-9-19(10-12-21)18-30-15-5-2-6-16-30/h1,3-4,7-14,17,25H,2,5-6,15-16,18H2,(H,29,32)
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n/an/a 7n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH&Co KG

Curated by ChEMBL


Assay Description
Inhibition of human VEGFR2 expressed in Sf9 cells


J Med Chem 52: 4466-80 (2009)


Article DOI: 10.1021/jm900431g
BindingDB Entry DOI: 10.7270/Q2RB75JS
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Homo sapiens (Human))
BDBM50279236
PNG
((Z)-3-({4-[(2-Imidazol-1-yl-acetyl)methylamino]-ph...)
Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(C)C(=O)Cn3ccnc3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C29H25N5O4/c1-33(25(35)17-34-15-14-30-18-34)22-11-9-21(10-12-22)31-27(19-6-4-3-5-7-19)26-23-13-8-20(29(37)38-2)16-24(23)32-28(26)36/h3-16,18,26H,17H2,1-2H3,(H,32,36)
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n/an/a 8n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH&Co KG

Curated by ChEMBL


Assay Description
Inhibition of human PDGFRalpha


J Med Chem 52: 4466-80 (2009)


Article DOI: 10.1021/jm900431g
BindingDB Entry DOI: 10.7270/Q2RB75JS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50279237
PNG
((Z)-3-{[4-(N-Acetyl-dimethylcarbamoylmethyl-amino)...)
Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(CC(=O)N(C)C)C(C)=O)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C29H28N4O5/c1-18(34)33(17-25(35)32(2)3)22-13-11-21(12-14-22)30-27(19-8-6-5-7-9-19)26-23-15-10-20(29(37)38-4)16-24(23)31-28(26)36/h5-16,26H,17H2,1-4H3,(H,31,36)
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Boehringer Ingelheim Pharma GmbH&Co KG

Curated by ChEMBL


Assay Description
Inhibition of human VEGFR2 expressed in Sf9 cells


J Med Chem 52: 4466-80 (2009)


Article DOI: 10.1021/jm900431g
BindingDB Entry DOI: 10.7270/Q2RB75JS
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Homo sapiens (Human))
BDBM50279267
PNG
((Z)-3-({4-[N-Acetyl-(2-dimethylaminoethyl)-amino]-...)
Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(CCN(C)C)C(C)=O)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C29H30N4O4/c1-19(34)33(17-16-32(2)3)23-13-11-22(12-14-23)30-27(20-8-6-5-7-9-20)26-24-15-10-21(29(36)37-4)18-25(24)31-28(26)35/h5-15,18,26H,16-17H2,1-4H3,(H,31,35)
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n/an/a 8n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH&Co KG

Curated by ChEMBL


Assay Description
Inhibition of human PDGFRalpha


J Med Chem 52: 4466-80 (2009)


Article DOI: 10.1021/jm900431g
BindingDB Entry DOI: 10.7270/Q2RB75JS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50279238
PNG
((Z)-3-({4-[N-Acetyl-(3-dimethylaminopropyl)-amino]...)
Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(CCCN(C)C)C(C)=O)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C30H32N4O4/c1-20(35)34(18-8-17-33(2)3)24-14-12-23(13-15-24)31-28(21-9-6-5-7-10-21)27-25-16-11-22(30(37)38-4)19-26(25)32-29(27)36/h5-7,9-16,19,27H,8,17-18H2,1-4H3,(H,32,36)
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n/an/a 9n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH&Co KG

Curated by ChEMBL


Assay Description
Inhibition of human VEGFR2 expressed in Sf9 cells


J Med Chem 52: 4466-80 (2009)


Article DOI: 10.1021/jm900431g
BindingDB Entry DOI: 10.7270/Q2RB75JS
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Homo sapiens (Human))
BDBM50279237
PNG
((Z)-3-{[4-(N-Acetyl-dimethylcarbamoylmethyl-amino)...)
Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(CC(=O)N(C)C)C(C)=O)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C29H28N4O5/c1-18(34)33(17-25(35)32(2)3)22-13-11-21(12-14-22)30-27(19-8-6-5-7-9-19)26-23-15-10-20(29(37)38-4)16-24(23)31-28(26)36/h5-16,26H,17H2,1-4H3,(H,31,36)
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n/an/a 9n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH&Co KG

Curated by ChEMBL


Assay Description
Inhibition of human PDGFRalpha


J Med Chem 52: 4466-80 (2009)


Article DOI: 10.1021/jm900431g
BindingDB Entry DOI: 10.7270/Q2RB75JS
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM50279045
PNG
((Z)-3-({4-[(2-Dimethylamino-acetyl)-methyl-amino]-...)
Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(CN(C)C(=O)N(C)C)cc3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C28H28N4O4/c1-31(2)28(35)32(3)17-18-10-13-21(14-11-18)29-25(19-8-6-5-7-9-19)24-22-15-12-20(27(34)36-4)16-23(22)30-26(24)33/h5-16,24H,17H2,1-4H3,(H,30,33)
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Boehringer Ingelheim Pharma GmbH&Co KG

Curated by ChEMBL


Assay Description
Inhibition of human VEGFR3


J Med Chem 52: 4466-80 (2009)


Article DOI: 10.1021/jm900431g
BindingDB Entry DOI: 10.7270/Q2RB75JS
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM50279268
PNG
((Z)-3-({4-[(2-Dimethylaminoethyl)-methanesulfonyl-...)
Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(CCN(C)C)S(C)(=O)=O)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C28H30N4O5S/c1-31(2)16-17-32(38(4,35)36)22-13-11-21(12-14-22)29-26(19-8-6-5-7-9-19)25-23-15-10-20(28(34)37-3)18-24(23)30-27(25)33/h5-15,18,25H,16-17H2,1-4H3,(H,30,33)
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Boehringer Ingelheim Pharma GmbH&Co KG

Curated by ChEMBL


Assay Description
Inhibition of human VEGFR3


J Med Chem 52: 4466-80 (2009)


Article DOI: 10.1021/jm900431g
BindingDB Entry DOI: 10.7270/Q2RB75JS
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Homo sapiens (Human))
BDBM50279269
PNG
((Z)-3-({4-[(3-Dimethylaminopropyl)-methyl-carbamoy...)
Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)C(=O)N(C)CCN(C)C)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C29H30N4O4/c1-32(2)16-17-33(3)28(35)20-10-13-22(14-11-20)30-26(19-8-6-5-7-9-19)25-23-15-12-21(29(36)37-4)18-24(23)31-27(25)34/h5-15,18,25H,16-17H2,1-4H3,(H,31,34)
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n/an/a 11n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH&Co KG

Curated by ChEMBL


Assay Description
Inhibition of human PDGFRalpha


J Med Chem 52: 4466-80 (2009)


Article DOI: 10.1021/jm900431g
BindingDB Entry DOI: 10.7270/Q2RB75JS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50279267
PNG
((Z)-3-({4-[N-Acetyl-(2-dimethylaminoethyl)-amino]-...)
Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(CCN(C)C)C(C)=O)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C29H30N4O4/c1-19(34)33(17-16-32(2)3)23-13-11-22(12-14-23)30-27(20-8-6-5-7-9-20)26-24-15-10-21(29(36)37-4)18-25(24)31-28(26)35/h5-15,18,26H,16-17H2,1-4H3,(H,31,35)
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n/an/a 12n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH&Co KG

Curated by ChEMBL


Assay Description
Inhibition of human VEGFR2 expressed in Sf9 cells


J Med Chem 52: 4466-80 (2009)


Article DOI: 10.1021/jm900431g
BindingDB Entry DOI: 10.7270/Q2RB75JS
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Homo sapiens (Human))
BDBM50279268
PNG
((Z)-3-({4-[(2-Dimethylaminoethyl)-methanesulfonyl-...)
Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(CCN(C)C)S(C)(=O)=O)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C28H30N4O5S/c1-31(2)16-17-32(38(4,35)36)22-13-11-21(12-14-22)29-26(19-8-6-5-7-9-19)25-23-15-10-20(28(34)37-3)18-24(23)30-27(25)33/h5-15,18,25H,16-17H2,1-4H3,(H,30,33)
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n/an/a 12n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH&Co KG

Curated by ChEMBL


Assay Description
Inhibition of human PDGFRalpha


J Med Chem 52: 4466-80 (2009)


Article DOI: 10.1021/jm900431g
BindingDB Entry DOI: 10.7270/Q2RB75JS
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50279080
PNG
((Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acety...)
Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,28H,15-18,20H2,1-3H3,(H,33,38)
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n/an/a 16n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH&Co KG

Curated by ChEMBL


Assay Description
Inhibition of human Lck


J Med Chem 52: 4466-80 (2009)


Article DOI: 10.1021/jm900431g
BindingDB Entry DOI: 10.7270/Q2RB75JS
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM50279238
PNG
((Z)-3-({4-[N-Acetyl-(3-dimethylaminopropyl)-amino]...)
Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(CCCN(C)C)C(C)=O)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C30H32N4O4/c1-20(35)34(18-8-17-33(2)3)24-14-12-23(13-15-24)31-28(21-9-6-5-7-10-21)27-25-16-11-22(30(37)38-4)19-26(25)32-29(27)36/h5-7,9-16,19,27H,8,17-18H2,1-4H3,(H,32,36)
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n/an/a 17n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH&Co KG

Curated by ChEMBL


Assay Description
Inhibition of human FGFR1


J Med Chem 52: 4466-80 (2009)


Article DOI: 10.1021/jm900431g
BindingDB Entry DOI: 10.7270/Q2RB75JS
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Homo sapiens (Human))
BDBM50279080
PNG
((Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acety...)
Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,28H,15-18,20H2,1-3H3,(H,33,38)
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n/an/a 18n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH&Co KG

Curated by ChEMBL


Assay Description
Inhibition of human PDGFRalpha


J Med Chem 52: 4466-80 (2009)


Article DOI: 10.1021/jm900431g
BindingDB Entry DOI: 10.7270/Q2RB75JS
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM50279267
PNG
((Z)-3-({4-[N-Acetyl-(2-dimethylaminoethyl)-amino]-...)
Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(CCN(C)C)C(C)=O)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C29H30N4O4/c1-19(34)33(17-16-32(2)3)23-13-11-22(12-14-23)30-27(20-8-6-5-7-9-20)26-24-15-10-21(29(36)37-4)18-25(24)31-28(26)35/h5-15,18,26H,16-17H2,1-4H3,(H,31,35)
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n/an/a 18n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH&Co KG

Curated by ChEMBL


Assay Description
Inhibition of human FGFR1


J Med Chem 52: 4466-80 (2009)


Article DOI: 10.1021/jm900431g
BindingDB Entry DOI: 10.7270/Q2RB75JS
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Homo sapiens (Human))
BDBM50279045
PNG
((Z)-3-({4-[(2-Dimethylamino-acetyl)-methyl-amino]-...)
Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(CN(C)C(=O)N(C)C)cc3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C28H28N4O4/c1-31(2)28(35)32(3)17-18-10-13-21(14-11-18)29-25(19-8-6-5-7-9-19)24-22-15-12-20(27(34)36-4)16-23(22)30-26(24)33/h5-16,24H,17H2,1-4H3,(H,30,33)
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n/an/a 20n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH&Co KG

Curated by ChEMBL


Assay Description
Inhibition of human PDGFRalpha


J Med Chem 52: 4466-80 (2009)


Article DOI: 10.1021/jm900431g
BindingDB Entry DOI: 10.7270/Q2RB75JS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50279268
PNG
((Z)-3-({4-[(2-Dimethylaminoethyl)-methanesulfonyl-...)
Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(CCN(C)C)S(C)(=O)=O)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C28H30N4O5S/c1-31(2)16-17-32(38(4,35)36)22-13-11-21(12-14-22)29-26(19-8-6-5-7-9-19)25-23-15-10-20(28(34)37-3)18-24(23)30-27(25)33/h5-15,18,25H,16-17H2,1-4H3,(H,30,33)
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n/an/a 23n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH&Co KG

Curated by ChEMBL


Assay Description
Inhibition of human VEGFR2 expressed in Sf9 cells


J Med Chem 52: 4466-80 (2009)


Article DOI: 10.1021/jm900431g
BindingDB Entry DOI: 10.7270/Q2RB75JS
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM50279298
PNG
((Z)-3-({4-[2-(4-Methylpiperazin-1-yl)acetylamino]-...)
Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(NC(=O)CN4CCN(C)CC4)cc3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C30H31N5O4/c1-34-14-16-35(17-15-34)19-26(36)31-22-9-11-23(12-10-22)32-28(20-6-4-3-5-7-20)27-24-13-8-21(30(38)39-2)18-25(24)33-29(27)37/h3-13,18,27H,14-17,19H2,1-2H3,(H,31,36)(H,33,37)
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n/an/a 24n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH&Co KG

Curated by ChEMBL


Assay Description
Inhibition of human VEGFR3


J Med Chem 52: 4466-80 (2009)


Article DOI: 10.1021/jm900431g
BindingDB Entry DOI: 10.7270/Q2RB75JS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50279269
PNG
((Z)-3-({4-[(3-Dimethylaminopropyl)-methyl-carbamoy...)
Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)C(=O)N(C)CCN(C)C)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C29H30N4O4/c1-32(2)16-17-33(3)28(35)20-10-13-22(14-11-20)30-26(19-8-6-5-7-9-19)25-23-15-12-21(29(36)37-4)18-24(23)31-27(25)34/h5-15,18,25H,16-17H2,1-4H3,(H,31,34)
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n/an/a 24n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH&Co KG

Curated by ChEMBL


Assay Description
Inhibition of human VEGFR2 expressed in Sf9 cells


J Med Chem 52: 4466-80 (2009)


Article DOI: 10.1021/jm900431g
BindingDB Entry DOI: 10.7270/Q2RB75JS
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM50279268
PNG
((Z)-3-({4-[(2-Dimethylaminoethyl)-methanesulfonyl-...)
Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(CCN(C)C)S(C)(=O)=O)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C28H30N4O5S/c1-31(2)16-17-32(38(4,35)36)22-13-11-21(12-14-22)29-26(19-8-6-5-7-9-19)25-23-15-10-20(28(34)37-3)18-24(23)30-27(25)33/h5-15,18,25H,16-17H2,1-4H3,(H,30,33)
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n/an/a 25n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH&Co KG

Curated by ChEMBL


Assay Description
Inhibition of human FGFR1


J Med Chem 52: 4466-80 (2009)


Article DOI: 10.1021/jm900431g
BindingDB Entry DOI: 10.7270/Q2RB75JS
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50279080
PNG
((Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acety...)
Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,28H,15-18,20H2,1-3H3,(H,33,38)
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n/an/a 26n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH&Co KG

Curated by ChEMBL


Assay Description
Inhibition of human Flt3


J Med Chem 52: 4466-80 (2009)


Article DOI: 10.1021/jm900431g
BindingDB Entry DOI: 10.7270/Q2RB75JS
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Homo sapiens (Human))
BDBM50279270
PNG
((Z)-3-[(4-Dimethylaminomethyl-phenylamino)-phenyl-...)
Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(CN(C)C)cc3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C26H25N3O3/c1-29(2)16-17-9-12-20(13-10-17)27-24(18-7-5-4-6-8-18)23-21-14-11-19(26(31)32-3)15-22(21)28-25(23)30/h4-15,23H,16H2,1-3H3,(H,28,30)
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n/an/a 28n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH&Co KG

Curated by ChEMBL


Assay Description
Inhibition of human PDGFRalpha


J Med Chem 52: 4466-80 (2009)


Article DOI: 10.1021/jm900431g
BindingDB Entry DOI: 10.7270/Q2RB75JS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50279238
PNG
((Z)-3-({4-[N-Acetyl-(3-dimethylaminopropyl)-amino]...)
Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(CCCN(C)C)C(C)=O)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C30H32N4O4/c1-20(35)34(18-8-17-33(2)3)24-14-12-23(13-15-24)31-28(21-9-6-5-7-10-21)27-25-16-11-22(30(37)38-4)19-26(25)32-29(27)36/h5-7,9-16,19,27H,8,17-18H2,1-4H3,(H,32,36)
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n/an/a 28n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH&Co KG

Curated by ChEMBL


Assay Description
Inhibition of human VEGFR1


J Med Chem 52: 4466-80 (2009)


Article DOI: 10.1021/jm900431g
BindingDB Entry DOI: 10.7270/Q2RB75JS
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM50279198
PNG
((Z)-2-oxo-3-[Phenyl-(4-piperidin-1-ylmethyl-phenyl...)
Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(CN4CCCCC4)cc3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C29H29N3O3/c1-35-29(34)22-12-15-24-25(18-22)31-28(33)26(24)27(21-8-4-2-5-9-21)30-23-13-10-20(11-14-23)19-32-16-6-3-7-17-32/h2,4-5,8-15,18,26H,3,6-7,16-17,19H2,1H3,(H,31,33)
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n/an/a 32n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH&Co KG

Curated by ChEMBL


Assay Description
Inhibition of human VEGFR3


J Med Chem 52: 4466-80 (2009)


Article DOI: 10.1021/jm900431g
BindingDB Entry DOI: 10.7270/Q2RB75JS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50279267
PNG
((Z)-3-({4-[N-Acetyl-(2-dimethylaminoethyl)-amino]-...)
Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(CCN(C)C)C(C)=O)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C29H30N4O4/c1-19(34)33(17-16-32(2)3)23-13-11-22(12-14-23)30-27(20-8-6-5-7-9-20)26-24-15-10-21(29(36)37-4)18-25(24)31-28(26)35/h5-15,18,26H,16-17H2,1-4H3,(H,31,35)
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n/an/a 35n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH&Co KG

Curated by ChEMBL


Assay Description
Inhibition of human VEGFR1


J Med Chem 52: 4466-80 (2009)


Article DOI: 10.1021/jm900431g
BindingDB Entry DOI: 10.7270/Q2RB75JS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50279198
PNG
((Z)-2-oxo-3-[Phenyl-(4-piperidin-1-ylmethyl-phenyl...)
Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(CN4CCCCC4)cc3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C29H29N3O3/c1-35-29(34)22-12-15-24-25(18-22)31-28(33)26(24)27(21-8-4-2-5-9-21)30-23-13-10-20(11-14-23)19-32-16-6-3-7-17-32/h2,4-5,8-15,18,26H,3,6-7,16-17,19H2,1H3,(H,31,33)
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n/an/a 36n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH&Co KG

Curated by ChEMBL


Assay Description
Inhibition of human VEGFR2 expressed in Sf9 cells


J Med Chem 52: 4466-80 (2009)


Article DOI: 10.1021/jm900431g
BindingDB Entry DOI: 10.7270/Q2RB75JS
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM50279080
PNG
((Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acety...)
Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,28H,15-18,20H2,1-3H3,(H,33,38)
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n/an/a 38n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH&Co KG

Curated by ChEMBL


Assay Description
Inhibition of human FGFR1


J Med Chem 52: 4466-80 (2009)


Article DOI: 10.1021/jm900431g
BindingDB Entry DOI: 10.7270/Q2RB75JS
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM50279045
PNG
((Z)-3-({4-[(2-Dimethylamino-acetyl)-methyl-amino]-...)
Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(CN(C)C(=O)N(C)C)cc3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C28H28N4O4/c1-31(2)28(35)32(3)17-18-10-13-21(14-11-18)29-25(19-8-6-5-7-9-19)24-22-15-12-20(27(34)36-4)16-23(22)30-26(24)33/h5-16,24H,17H2,1-4H3,(H,30,33)
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n/an/a 50n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH&Co KG

Curated by ChEMBL


Assay Description
Inhibition of human FGFR1


J Med Chem 52: 4466-80 (2009)


Article DOI: 10.1021/jm900431g
BindingDB Entry DOI: 10.7270/Q2RB75JS
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor


(Homo sapiens (Human))
BDBM50279198
PNG
((Z)-2-oxo-3-[Phenyl-(4-piperidin-1-ylmethyl-phenyl...)
Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(CN4CCCCC4)cc3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C29H29N3O3/c1-35-29(34)22-12-15-24-25(18-22)31-28(33)26(24)27(21-8-4-2-5-9-21)30-23-13-10-20(11-14-23)19-32-16-6-3-7-17-32/h2,4-5,8-15,18,26H,3,6-7,16-17,19H2,1H3,(H,31,33)
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n/an/a 54n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH&Co KG

Curated by ChEMBL


Assay Description
Inhibition of human PDGFRalpha


J Med Chem 52: 4466-80 (2009)


Article DOI: 10.1021/jm900431g
BindingDB Entry DOI: 10.7270/Q2RB75JS
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM50279237
PNG
((Z)-3-{[4-(N-Acetyl-dimethylcarbamoylmethyl-amino)...)
Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(CC(=O)N(C)C)C(C)=O)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C29H28N4O5/c1-18(34)33(17-25(35)32(2)3)22-13-11-21(12-14-22)30-27(19-8-6-5-7-9-19)26-23-15-10-20(29(37)38-4)16-24(23)31-28(26)36/h5-16,26H,17H2,1-4H3,(H,31,36)
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n/an/a 54n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH&Co KG

Curated by ChEMBL


Assay Description
Inhibition of human FGFR1


J Med Chem 52: 4466-80 (2009)


Article DOI: 10.1021/jm900431g
BindingDB Entry DOI: 10.7270/Q2RB75JS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50279236
PNG
((Z)-3-({4-[(2-Imidazol-1-yl-acetyl)methylamino]-ph...)
Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(C)C(=O)Cn3ccnc3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C29H25N5O4/c1-33(25(35)17-34-15-14-30-18-34)22-11-9-21(10-12-22)31-27(19-6-4-3-5-7-19)26-23-13-8-20(29(37)38-2)16-24(23)32-28(26)36/h3-16,18,26H,17H2,1-2H3,(H,32,36)
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n/an/a 55n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH&Co KG

Curated by ChEMBL


Assay Description
Inhibition of human VEGFR1


J Med Chem 52: 4466-80 (2009)


Article DOI: 10.1021/jm900431g
BindingDB Entry DOI: 10.7270/Q2RB75JS
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM50279269
PNG
((Z)-3-({4-[(3-Dimethylaminopropyl)-methyl-carbamoy...)
Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)C(=O)N(C)CCN(C)C)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C29H30N4O4/c1-32(2)16-17-33(3)28(35)20-10-13-22(14-11-20)30-26(19-8-6-5-7-9-19)25-23-15-12-21(29(36)37-4)18-24(23)31-27(25)34/h5-15,18,25H,16-17H2,1-4H3,(H,31,34)
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n/an/a 59n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH&Co KG

Curated by ChEMBL


Assay Description
Inhibition of human VEGFR3


J Med Chem 52: 4466-80 (2009)


Article DOI: 10.1021/jm900431g
BindingDB Entry DOI: 10.7270/Q2RB75JS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50279045
PNG
((Z)-3-({4-[(2-Dimethylamino-acetyl)-methyl-amino]-...)
Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(CN(C)C(=O)N(C)C)cc3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C28H28N4O4/c1-31(2)28(35)32(3)17-18-10-13-21(14-11-18)29-25(19-8-6-5-7-9-19)24-22-15-12-20(27(34)36-4)16-23(22)30-26(24)33/h5-16,24H,17H2,1-4H3,(H,30,33)
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n/an/a 61n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH&Co KG

Curated by ChEMBL


Assay Description
Inhibition of human VEGFR2 expressed in Sf9 cells


J Med Chem 52: 4466-80 (2009)


Article DOI: 10.1021/jm900431g
BindingDB Entry DOI: 10.7270/Q2RB75JS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50279237
PNG
((Z)-3-{[4-(N-Acetyl-dimethylcarbamoylmethyl-amino)...)
Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(CC(=O)N(C)C)C(C)=O)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C29H28N4O5/c1-18(34)33(17-25(35)32(2)3)22-13-11-21(12-14-22)30-27(19-8-6-5-7-9-19)26-23-15-10-20(29(37)38-4)16-24(23)31-28(26)36/h5-16,26H,17H2,1-4H3,(H,31,36)
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n/an/a 61n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH&Co KG

Curated by ChEMBL


Assay Description
Inhibition of human VEGFR1


J Med Chem 52: 4466-80 (2009)


Article DOI: 10.1021/jm900431g
BindingDB Entry DOI: 10.7270/Q2RB75JS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50279270
PNG
((Z)-3-[(4-Dimethylaminomethyl-phenylamino)-phenyl-...)
Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(CN(C)C)cc3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C26H25N3O3/c1-29(2)16-17-9-12-20(13-10-17)27-24(18-7-5-4-6-8-18)23-21-14-11-19(26(31)32-3)15-22(21)28-25(23)30/h4-15,23H,16H2,1-3H3,(H,28,30)
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n/an/a 64n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH&Co KG

Curated by ChEMBL


Assay Description
Inhibition of human VEGFR2 expressed in Sf9 cells


J Med Chem 52: 4466-80 (2009)


Article DOI: 10.1021/jm900431g
BindingDB Entry DOI: 10.7270/Q2RB75JS
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM50279236
PNG
((Z)-3-({4-[(2-Imidazol-1-yl-acetyl)methylamino]-ph...)
Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(C)C(=O)Cn3ccnc3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C29H25N5O4/c1-33(25(35)17-34-15-14-30-18-34)22-11-9-21(10-12-22)31-27(19-6-4-3-5-7-19)26-23-13-8-20(29(37)38-2)16-24(23)32-28(26)36/h3-16,18,26H,17H2,1-2H3,(H,32,36)
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n/an/a 66n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH&Co KG

Curated by ChEMBL


Assay Description
Inhibition of human FGFR1


J Med Chem 52: 4466-80 (2009)


Article DOI: 10.1021/jm900431g
BindingDB Entry DOI: 10.7270/Q2RB75JS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50279268
PNG
((Z)-3-({4-[(2-Dimethylaminoethyl)-methanesulfonyl-...)
Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(CCN(C)C)S(C)(=O)=O)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C28H30N4O5S/c1-31(2)16-17-32(38(4,35)36)22-13-11-21(12-14-22)29-26(19-8-6-5-7-9-19)25-23-15-10-20(28(34)37-3)18-24(23)30-27(25)33/h5-15,18,25H,16-17H2,1-4H3,(H,30,33)
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n/an/a 69n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH&Co KG

Curated by ChEMBL


Assay Description
Inhibition of human VEGFR1


J Med Chem 52: 4466-80 (2009)


Article DOI: 10.1021/jm900431g
BindingDB Entry DOI: 10.7270/Q2RB75JS
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM50279198
PNG
((Z)-2-oxo-3-[Phenyl-(4-piperidin-1-ylmethyl-phenyl...)
Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(CN4CCCCC4)cc3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C29H29N3O3/c1-35-29(34)22-12-15-24-25(18-22)31-28(33)26(24)27(21-8-4-2-5-9-21)30-23-13-10-20(11-14-23)19-32-16-6-3-7-17-32/h2,4-5,8-15,18,26H,3,6-7,16-17,19H2,1H3,(H,31,33)
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n/an/a 71n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH&Co KG

Curated by ChEMBL


Assay Description
Inhibition of human FGFR1


J Med Chem 52: 4466-80 (2009)


Article DOI: 10.1021/jm900431g
BindingDB Entry DOI: 10.7270/Q2RB75JS
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM50279270
PNG
((Z)-3-[(4-Dimethylaminomethyl-phenylamino)-phenyl-...)
Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(CN(C)C)cc3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C26H25N3O3/c1-29(2)16-17-9-12-20(13-10-17)27-24(18-7-5-4-6-8-18)23-21-14-11-19(26(31)32-3)15-22(21)28-25(23)30/h4-15,23H,16H2,1-3H3,(H,28,30)
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n/an/a 73n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH&Co KG

Curated by ChEMBL


Assay Description
Inhibition of human VEGFR3


J Med Chem 52: 4466-80 (2009)


Article DOI: 10.1021/jm900431g
BindingDB Entry DOI: 10.7270/Q2RB75JS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50279045
PNG
((Z)-3-({4-[(2-Dimethylamino-acetyl)-methyl-amino]-...)
Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(CN(C)C(=O)N(C)C)cc3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C28H28N4O4/c1-31(2)28(35)32(3)17-18-10-13-21(14-11-18)29-25(19-8-6-5-7-9-19)24-22-15-12-20(27(34)36-4)16-23(22)30-26(24)33/h5-16,24H,17H2,1-4H3,(H,30,33)
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n/an/a 82n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH&Co KG

Curated by ChEMBL


Assay Description
Inhibition of human VEGFR1


J Med Chem 52: 4466-80 (2009)


Article DOI: 10.1021/jm900431g
BindingDB Entry DOI: 10.7270/Q2RB75JS
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM50279270
PNG
((Z)-3-[(4-Dimethylaminomethyl-phenylamino)-phenyl-...)
Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(CN(C)C)cc3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C26H25N3O3/c1-29(2)16-17-9-12-20(13-10-17)27-24(18-7-5-4-6-8-18)23-21-14-11-19(26(31)32-3)15-22(21)28-25(23)30/h4-15,23H,16H2,1-3H3,(H,28,30)
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n/an/a 82n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH&Co KG

Curated by ChEMBL


Assay Description
Inhibition of human FGFR1


J Med Chem 52: 4466-80 (2009)


Article DOI: 10.1021/jm900431g
BindingDB Entry DOI: 10.7270/Q2RB75JS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50279298
PNG
((Z)-3-({4-[2-(4-Methylpiperazin-1-yl)acetylamino]-...)
Show SMILES COC(=O)c1ccc2C(C(=Nc3ccc(NC(=O)CN4CCN(C)CC4)cc3)c3ccccc3)C(=O)Nc2c1
Show InChI InChI=1S/C30H31N5O4/c1-34-14-16-35(17-15-34)19-26(36)31-22-9-11-23(12-10-22)32-28(20-6-4-3-5-7-20)27-24-13-8-21(30(38)39-2)18-25(24)33-29(27)37/h3-13,18,27H,14-17,19H2,1-2H3,(H,31,36)(H,33,37)
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n/an/a 83n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH&Co KG

Curated by ChEMBL


Assay Description
Inhibition of human VEGFR2 expressed in Sf9 cells


J Med Chem 52: 4466-80 (2009)


Article DOI: 10.1021/jm900431g
BindingDB Entry DOI: 10.7270/Q2RB75JS
More data for this
Ligand-Target Pair
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