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Compile Data Set for Download or QSAR

Found 172 hits from Boehringer-Ingelheim International GmbH   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177650
PNG
(US9120769, 152)
Show SMILES Cc1cc(cc2nc[nH]c12)C(=O)N1CCC[C@H]2[C@@H]1Cc1ccc(cc21)C#N
Show InChI InChI=1S/C22H20N4O/c1-13-7-16(9-19-21(13)25-12-24-19)22(27)26-6-2-3-17-18-8-14(11-23)4-5-15(18)10-20(17)26/h4-5,7-9,12,17,20H,2-3,6,10H2,1H3,(H,24,25)/t17-,20+/m1/s1
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n/an/a 24n/an/an/an/an/an/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177639
PNG
(US9120769, 107)
Show SMILES O=C(N1CCC[C@H]2[C@@H]1Cc1ccc(cc21)C#N)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C21H18N4O/c22-11-13-3-4-14-10-20-16(17(14)8-13)2-1-7-25(20)21(26)15-5-6-18-19(9-15)24-12-23-18/h3-6,8-9,12,16,20H,1-2,7,10H2,(H,23,24)/t16-,20+/m1/s1
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n/an/a 26n/an/an/an/an/an/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177638
PNG
(US9120769, 106)
Show SMILES O=C(N1CCCC2[C@@H]1Cc1ccc(cc21)C#N)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C21H18N4O/c22-11-13-3-4-14-10-20-16(17(14)8-13)2-1-7-25(20)21(26)15-5-6-18-19(9-15)24-12-23-18/h3-6,8-9,12,16,20H,1-2,7,10H2,(H,23,24)/t16?,20-/m0/s1
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n/an/a 31n/an/an/an/an/an/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177651
PNG
(US9120769, 153)
Show SMILES Cc1cc2[nH]cnc2cc1C(=O)N1CCC[C@H]2[C@@H]1Cc1ccc(cc21)C#N
Show InChI InChI=1S/C22H20N4O/c1-13-7-19-20(25-12-24-19)10-17(13)22(27)26-6-2-3-16-18-8-14(11-23)4-5-15(18)9-21(16)26/h4-5,7-8,10,12,16,21H,2-3,6,9H2,1H3,(H,24,25)/t16-,21+/m1/s1
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n/an/a 48n/an/an/an/an/an/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177645
PNG
(US9120769, 146)
Show SMILES C[C@H]1CCN([C@H]2Cc3ccccc3[C@@H]12)C(=O)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C21H21N3O/c1-13-8-9-24(19-11-14-4-2-3-5-16(14)20(13)19)21(25)15-6-7-17-18(10-15)23-12-22-17/h2-7,10,12-13,19-20H,8-9,11H2,1H3,(H,22,23)/t13-,19-,20+/m0/s1
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n/an/a 55n/an/an/an/an/an/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177578
PNG
(US9120769, 1 | US9120769, 2)
Show SMILES O=C(N1CCCC2[C@@H]1CCc1ccccc21)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C21H21N3O/c25-21(15-7-9-18-19(12-15)23-13-22-18)24-11-3-6-17-16-5-2-1-4-14(16)8-10-20(17)24/h1-2,4-5,7,9,12-13,17,20H,3,6,8,10-11H2,(H,22,23)/t17?,20-/m0/s1
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n/an/a 65n/an/an/an/an/an/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177672
PNG
(US9120769, 174)
Show SMILES Cc1cc2C[C@H]3[C@H](CCCN3C(=O)c3ccc4[nH]cnc4c3)c2cc1C#N
Show InChI InChI=1S/C22H20N4O/c1-13-7-15-10-21-17(18(15)8-16(13)11-23)3-2-6-26(21)22(27)14-4-5-19-20(9-14)25-12-24-19/h4-5,7-9,12,17,21H,2-3,6,10H2,1H3,(H,24,25)/t17-,21+/m1/s1
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n/an/a 67n/an/an/an/an/an/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177661
PNG
(US9120769, 163)
Show SMILES Cc1ccc2C[C@H]3[C@H](CCCN3C(=O)c3ccc4[nH]cnc4c3)c2c1
Show InChI InChI=1S/C21H21N3O/c1-13-4-5-14-11-20-16(17(14)9-13)3-2-8-24(20)21(25)15-6-7-18-19(10-15)23-12-22-18/h4-7,9-10,12,16,20H,2-3,8,11H2,1H3,(H,22,23)/t16-,20+/m1/s1
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n/an/a 67n/an/an/an/an/an/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177653
PNG
(US9120769, 155)
Show SMILES O=C(N1CCC[C@H]2[C@@H]1Cc1ccc(cc21)C#C)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C22H19N3O/c1-2-14-5-6-15-12-21-17(18(15)10-14)4-3-9-25(21)22(26)16-7-8-19-20(11-16)24-13-23-19/h1,5-8,10-11,13,17,21H,3-4,9,12H2,(H,23,24)/t17-,21+/m1/s1
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n/an/a 83n/an/an/an/an/an/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177630
PNG
(US9120769, 94)
Show SMILES O=C(N1CCC[C@H]2[C@@H]1Cc1ccccc21)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C20H19N3O/c24-20(14-7-8-17-18(10-14)22-12-21-17)23-9-3-6-16-15-5-2-1-4-13(15)11-19(16)23/h1-2,4-5,7-8,10,12,16,19H,3,6,9,11H2,(H,21,22)/t16-,19+/m1/s1
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n/an/a 90n/an/an/an/an/an/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177587
PNG
(US9120769, 11)
Show SMILES C[C@]12CCCN([C@@H]1CCc1ccccc21)C(=O)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C22H23N3O/c1-22-11-4-12-25(20(22)10-8-15-5-2-3-6-17(15)22)21(26)16-7-9-18-19(13-16)24-14-23-18/h2-3,5-7,9,13-14,20H,4,8,10-12H2,1H3,(H,23,24)/t20-,22-/m1/s1
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n/an/a 94n/an/an/an/an/an/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177578
PNG
(US9120769, 1 | US9120769, 2)
Show SMILES O=C(N1CCCC2[C@@H]1CCc1ccccc21)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C21H21N3O/c25-21(15-7-9-18-19(12-15)23-13-22-18)24-11-3-6-17-16-5-2-1-4-14(16)8-10-20(17)24/h1-2,4-5,7,9,12-13,17,20H,3,6,8,10-11H2,(H,22,23)/t17?,20-/m0/s1
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n/an/a 106n/an/an/an/an/an/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177629
PNG
(US9120769, 93)
Show SMILES O=C(N1CCCC2[C@@H]1Cc1ccccc21)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C20H19N3O/c24-20(14-7-8-17-18(10-14)22-12-21-17)23-9-3-6-16-15-5-2-1-4-13(15)11-19(16)23/h1-2,4-5,7-8,10,12,16,19H,3,6,9,11H2,(H,21,22)/t16?,19-/m0/s1
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n/an/a 121n/an/an/an/an/an/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177598
PNG
(US9120769, 22)
Show SMILES COc1ccc2C3CCCN([C@H]3CCc2c1)C(=O)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C22H23N3O2/c1-27-16-6-7-17-14(11-16)5-9-21-18(17)3-2-10-25(21)22(26)15-4-8-19-20(12-15)24-13-23-19/h4,6-8,11-13,18,21H,2-3,5,9-10H2,1H3,(H,23,24)/t18?,21-/m0/s1
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n/an/a 123n/an/an/an/an/an/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177647
PNG
(US9120769, 149)
Show SMILES COc1ccc2C[C@H]3[C@H](CCCN3C(=O)c3ccc4[nH]cnc4c3)c2c1
Show InChI InChI=1S/C21H21N3O2/c1-26-15-6-4-13-10-20-16(17(13)11-15)3-2-8-24(20)21(25)14-5-7-18-19(9-14)23-12-22-18/h4-7,9,11-12,16,20H,2-3,8,10H2,1H3,(H,22,23)/t16-,20+/m1/s1
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n/an/a 141n/an/an/an/an/an/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177640
PNG
(US9120769, 108)
Show SMILES O=C(N1CCC[C@@H]2[C@H]1Cc1ccc(cc21)C#N)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C21H18N4O/c22-11-13-3-4-14-10-20-16(17(14)8-13)2-1-7-25(20)21(26)15-5-6-18-19(9-15)24-12-23-18/h3-6,8-9,12,16,20H,1-2,7,10H2,(H,23,24)/t16-,20+/m0/s1
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n/an/a 150n/an/an/an/an/an/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177610
PNG
(US9120769, 37)
Show SMILES NC(=O)c1ccc2C3CCCN([C@H]3CCc2c1)C(=O)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C22H22N4O2/c23-21(27)14-3-6-16-13(10-14)5-8-20-17(16)2-1-9-26(20)22(28)15-4-7-18-19(11-15)25-12-24-18/h3-4,6-7,10-12,17,20H,1-2,5,8-9H2,(H2,23,27)(H,24,25)/t17?,20-/m0/s1
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n/an/a 150n/an/an/an/an/an/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177664
PNG
(US9120769, 166)
Show SMILES CC(=O)Nc1ccc2[C@H]3CCCN([C@H]3Cc2c1)C(=O)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C22H22N4O2/c1-13(27)25-16-5-6-17-15(9-16)11-21-18(17)3-2-8-26(21)22(28)14-4-7-19-20(10-14)24-12-23-19/h4-7,9-10,12,18,21H,2-3,8,11H2,1H3,(H,23,24)(H,25,27)/t18-,21+/m1/s1
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n/an/a 182n/an/an/an/an/an/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99403
PNG
(US8497281, 181 | US9120769, 114)
Show SMILES O=C(N1CCCC2[C@@H]1Cc1ccccc21)c1ccc2cc[nH]c2c1
Show InChI InChI=1S/C21H20N2O/c24-21(16-8-7-14-9-10-22-19(14)12-16)23-11-3-6-18-17-5-2-1-4-15(17)13-20(18)23/h1-2,4-5,7-10,12,18,20,22H,3,6,11,13H2/t18?,20-/m0/s1
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n/an/a 185n/an/an/an/an/an/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177649
PNG
(US9120769, 151)
Show SMILES Nc1ccc2[C@H]3CCCN([C@H]3Cc2c1)C(=O)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C20H20N4O/c21-14-4-5-15-13(8-14)10-19-16(15)2-1-7-24(19)20(25)12-3-6-17-18(9-12)23-11-22-17/h3-6,8-9,11,16,19H,1-2,7,10,21H2,(H,22,23)/t16-,19+/m1/s1
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n/an/a 188n/an/an/an/an/an/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177659
PNG
(US9120769, 161)
Show SMILES CC#Cc1ccc2C[C@H]3[C@H](CCCN3C(=O)c3ccc4[nH]cnc4c3)c2c1
Show InChI InChI=1S/C23H21N3O/c1-2-4-15-6-7-16-13-22-18(19(16)11-15)5-3-10-26(22)23(27)17-8-9-20-21(12-17)25-14-24-20/h6-9,11-12,14,18,22H,3,5,10,13H2,1H3,(H,24,25)/t18-,22+/m1/s1
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n/an/a 212n/an/an/an/an/an/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99354
PNG
(US8497281, 132 | US9120769, 65)
Show SMILES O=C(N1CCCC2[C@@H]1CCc1ccccc21)c1ccc2[nH]ncc2c1
Show InChI InChI=1S/C21H21N3O/c25-21(15-7-9-19-16(12-15)13-22-23-19)24-11-3-6-18-17-5-2-1-4-14(17)8-10-20(18)24/h1-2,4-5,7,9,12-13,18,20H,3,6,8,10-11H2,(H,22,23)/t18?,20-/m0/s1
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n/an/a 212n/an/an/an/an/an/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177646
PNG
(US9120769, 148)
Show SMILES O=C(N1CCC[C@H]2[C@@H]1Cc1cc(ccc21)C#N)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C21H18N4O/c22-11-13-3-5-16-15(8-13)10-20-17(16)2-1-7-25(20)21(26)14-4-6-18-19(9-14)24-12-23-18/h3-6,8-9,12,17,20H,1-2,7,10H2,(H,23,24)/t17-,20+/m1/s1
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n/an/a 214n/an/an/an/an/an/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177669
PNG
(US9120769, 171)
Show SMILES O=C(N1CCC[C@H]2[C@@H]1Cc1cc3ncoc3cc21)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C21H18N4O2/c26-21(12-3-4-16-17(6-12)23-10-22-16)25-5-1-2-14-15-9-20-18(24-11-27-20)7-13(15)8-19(14)25/h3-4,6-7,9-11,14,19H,1-2,5,8H2,(H,22,23)/t14-,19+/m1/s1
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n/an/a 218n/an/an/an/an/an/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177596
PNG
(US9120769, 20)
Show SMILES Fc1cc(F)c2CC[C@H]3C(CCCN3C(=O)c3ccc4[nH]cnc4c3)c2c1
Show InChI InChI=1S/C21H19F2N3O/c22-13-9-16-14(17(23)10-13)4-6-20-15(16)2-1-7-26(20)21(27)12-3-5-18-19(8-12)25-11-24-18/h3,5,8-11,15,20H,1-2,4,6-7H2,(H,24,25)/t15?,20-/m0/s1
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n/an/a 227n/an/an/an/an/an/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99411
PNG
(US8497281, 189 | US9120769, 122)
Show SMILES Nc1ccc(cc1Cl)C(=O)N1CCCC2[C@@H]1Cc1ccccc21
Show InChI InChI=1S/C19H19ClN2O/c20-16-10-13(7-8-17(16)21)19(23)22-9-3-6-15-14-5-2-1-4-12(14)11-18(15)22/h1-2,4-5,7-8,10,15,18H,3,6,9,11,21H2/t15?,18-/m0/s1
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n/an/a 230n/an/an/an/an/an/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177627
PNG
(US9120769, 91)
Show SMILES O=C(N1CCCC2[C@@H]1CCc1ccc(cc21)C#N)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C22H20N4O/c23-12-14-3-4-15-6-8-21-17(18(15)10-14)2-1-9-26(21)22(27)16-5-7-19-20(11-16)25-13-24-19/h3-5,7,10-11,13,17,21H,1-2,6,8-9H2,(H,24,25)/t17?,21-/m0/s1
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n/an/a 244n/an/an/an/an/an/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177668
PNG
(US9120769, 170)
Show SMILES Cc1nc2cc3C[C@H]4[C@H](CCCN4C(=O)c4ccc5[nH]cnc5c4)c3cc2o1
Show InChI InChI=1S/C22H20N4O2/c1-12-25-19-8-14-9-20-15(16(14)10-21(19)28-12)3-2-6-26(20)22(27)13-4-5-17-18(7-13)24-11-23-17/h4-5,7-8,10-11,15,20H,2-3,6,9H2,1H3,(H,23,24)/t15-,20+/m1/s1
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n/an/a 248n/an/an/an/an/an/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177589
PNG
(US9120769, 13)
Show SMILES Oc1cccc2CC[C@H]3C(CCCN3C(=O)c3ccc4[nH]cnc4c3)c12
Show InChI InChI=1S/C21H21N3O2/c25-19-5-1-3-13-7-9-18-15(20(13)19)4-2-10-24(18)21(26)14-6-8-16-17(11-14)23-12-22-16/h1,3,5-6,8,11-12,15,18,25H,2,4,7,9-10H2,(H,22,23)/t15?,18-/m0/s1
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n/an/a 257n/an/an/an/an/an/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99367
PNG
(US8497281, 145 | US9120769, 78)
Show SMILES COc1cc(ccc1N)C(=O)N1CCCC2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C21H24N2O2/c1-25-20-13-15(8-10-18(20)22)21(24)23-12-4-7-17-16-6-3-2-5-14(16)9-11-19(17)23/h2-3,5-6,8,10,13,17,19H,4,7,9,11-12,22H2,1H3/t17?,19-/m0/s1
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n/an/a 257n/an/an/an/an/an/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177637
PNG
(US9120769, 105)
Show SMILES CC[C@]12CCCN([C@@H]1CCc1ccccc21)C(=O)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C23H25N3O/c1-2-23-12-5-13-26(21(23)11-9-16-6-3-4-7-18(16)23)22(27)17-8-10-19-20(14-17)25-15-24-19/h3-4,6-8,10,14-15,21H,2,5,9,11-13H2,1H3,(H,24,25)/t21-,23-/m1/s1
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n/an/a 263n/an/an/an/an/an/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177582
PNG
(US9120769, 6)
Show SMILES COc1cccc2C3CCCN([C@H]3CCc12)C(=O)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C22H23N3O2/c1-27-21-6-2-4-15-16-5-3-11-25(20(16)10-8-17(15)21)22(26)14-7-9-18-19(12-14)24-13-23-18/h2,4,6-7,9,12-13,16,20H,3,5,8,10-11H2,1H3,(H,23,24)/t16?,20-/m0/s1
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n/an/a 296n/an/an/an/an/an/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177603
PNG
(US9120769, 27)
Show SMILES Fc1cccc2CC[C@H]3C(CCCN3C(=O)c3ccc4[nH]cnc4c3)c12
Show InChI InChI=1S/C21H20FN3O/c22-16-5-1-3-13-7-9-19-15(20(13)16)4-2-10-25(19)21(26)14-6-8-17-18(11-14)24-12-23-17/h1,3,5-6,8,11-12,15,19H,2,4,7,9-10H2,(H,23,24)/t15?,19-/m0/s1
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n/an/a 297n/an/an/an/an/an/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177609
PNG
(US9120769, 36)
Show SMILES CNC(=O)c1ccc2C3CCCN([C@H]3CCc2c1)C(=O)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C23H24N4O2/c1-24-22(28)15-4-7-17-14(11-15)6-9-21-18(17)3-2-10-27(21)23(29)16-5-8-19-20(12-16)26-13-25-19/h4-5,7-8,11-13,18,21H,2-3,6,9-10H2,1H3,(H,24,28)(H,25,26)/t18?,21-/m0/s1
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n/an/a 310n/an/an/an/an/an/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177666
PNG
(US9120769, 168)
Show SMILES Oc1cc2[C@H]3CCCN([C@H]3Cc2cc1[N+]([O-])=O)C(=O)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C20H18N4O4/c25-19-9-14-12(8-18(19)24(27)28)7-17-13(14)2-1-5-23(17)20(26)11-3-4-15-16(6-11)22-10-21-15/h3-4,6,8-10,13,17,25H,1-2,5,7H2,(H,21,22)/t13-,17+/m1/s1
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n/an/a 313n/an/an/an/an/an/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99421
PNG
(US8497281, 199 | US9120769, 132)
Show SMILES O=C(N1CCCC2[C@@H]1Cc1ccccc21)c1ccc2[nH]ncc2c1
Show InChI InChI=1S/C20H19N3O/c24-20(14-7-8-18-15(10-14)12-21-22-18)23-9-3-6-17-16-5-2-1-4-13(16)11-19(17)23/h1-2,4-5,7-8,10,12,17,19H,3,6,9,11H2,(H,21,22)/t17?,19-/m0/s1
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n/an/a 320n/an/an/an/an/an/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177586
PNG
(US9120769, 10)
Show SMILES C[C@]12CCCN([C@H]1CCc1ccccc21)C(=O)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C22H23N3O/c1-22-11-4-12-25(20(22)10-8-15-5-2-3-6-17(15)22)21(26)16-7-9-18-19(13-16)24-14-23-18/h2-3,5-7,9,13-14,20H,4,8,10-12H2,1H3,(H,23,24)/t20-,22+/m0/s1
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n/an/a 321n/an/an/an/an/an/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99364
PNG
(US8497281, 142 | US9120769, 75)
Show SMILES Oc1ccc(cc1Cl)C(=O)N1CCCC2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C20H20ClNO2/c21-17-12-14(8-10-19(17)23)20(24)22-11-3-6-16-15-5-2-1-4-13(15)7-9-18(16)22/h1-2,4-5,8,10,12,16,18,23H,3,6-7,9,11H2/t16?,18-/m0/s1
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n/an/a 324n/an/an/an/an/an/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99430
PNG
(US8497281, 208 | US9120769, 141)
Show SMILES Oc1ccc(cc1Cl)C(=O)N1CCCC2[C@@H]1Cc1ccccc21
Show InChI InChI=1S/C19H18ClNO2/c20-16-10-13(7-8-18(16)22)19(23)21-9-3-6-15-14-5-2-1-4-12(14)11-17(15)21/h1-2,4-5,7-8,10,15,17,22H,3,6,9,11H2/t15?,17-/m0/s1
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n/an/a 326n/an/an/an/an/an/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177584
PNG
(US9120769, 8)
Show SMILES COc1cccc2CC[C@H]3C(CCCN3C(=O)c3ccc4[nH]cnc4c3)c12
Show InChI InChI=1S/C22H23N3O2/c1-27-20-6-2-4-14-8-10-19-16(21(14)20)5-3-11-25(19)22(26)15-7-9-17-18(12-15)24-13-23-17/h2,4,6-7,9,12-13,16,19H,3,5,8,10-11H2,1H3,(H,23,24)/t16?,19-/m0/s1
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n/an/a 342n/an/an/an/an/an/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99359
PNG
(US8497281, 137 | US9120769, 70)
Show SMILES O=C(N1CCCC2[C@@H]1CCc1ccccc21)c1c[nH]c2ccccc12
Show InChI InChI=1S/C22H22N2O/c25-22(19-14-23-20-10-4-3-8-17(19)20)24-13-5-9-18-16-7-2-1-6-15(16)11-12-21(18)24/h1-4,6-8,10,14,18,21,23H,5,9,11-13H2/t18?,21-/m0/s1
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n/an/a 350n/an/an/an/an/an/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177660
PNG
(US9120769, 162)
Show SMILES Cn1cc(cn1)-c1ccc2C[C@H]3[C@H](CCCN3C(=O)c3ccc4[nH]cnc4c3)c2c1
Show InChI InChI=1S/C24H23N5O/c1-28-13-18(12-27-28)15-4-5-16-11-23-19(20(16)9-15)3-2-8-29(23)24(30)17-6-7-21-22(10-17)26-14-25-21/h4-7,9-10,12-14,19,23H,2-3,8,11H2,1H3,(H,25,26)/t19-,23+/m1/s1
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n/an/a 354n/an/an/an/an/an/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99345
PNG
(US8497281, 123 | US9120769, 56)
Show SMILES Nc1ccc(cc1Cl)C(=O)N1CCCC2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C20H21ClN2O/c21-17-12-14(7-9-18(17)22)20(24)23-11-3-6-16-15-5-2-1-4-13(15)8-10-19(16)23/h1-2,4-5,7,9,12,16,19H,3,6,8,10-11,22H2/t16?,19-/m0/s1
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n/an/a 356n/an/an/an/an/an/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177641
PNG
(US9120769, 119)
Show SMILES Oc1ccc2[C@H]3CCCN([C@H]3Cc2c1)C(=O)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C20H19N3O2/c24-14-4-5-15-13(8-14)10-19-16(15)2-1-7-23(19)20(25)12-3-6-17-18(9-12)22-11-21-17/h3-6,8-9,11,16,19,24H,1-2,7,10H2,(H,21,22)/t16-,19+/m1/s1
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n/an/a 365n/an/an/an/an/an/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177658
PNG
(US9120769, 160)
Show SMILES O=C(N1CCC[C@H]2[C@@H]1Cc1ccc(cc21)-c1ccoc1)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C24H21N3O2/c28-24(17-5-6-21-22(11-17)26-14-25-21)27-8-1-2-19-20-10-15(18-7-9-29-13-18)3-4-16(20)12-23(19)27/h3-7,9-11,13-14,19,23H,1-2,8,12H2,(H,25,26)/t19-,23+/m1/s1
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n/an/a 367n/an/an/an/an/an/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177588
PNG
(US9120769, 12)
Show SMILES COc1cccc2C3CCCN([C@@H]3CCc12)C(=O)c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C22H23N3O2/c1-27-21-6-2-4-15-16-5-3-11-25(20(16)10-8-17(15)21)22(26)14-7-9-18-19(12-14)24-13-23-18/h2,4,6-7,9,12-13,16,20H,3,5,8,10-11H2,1H3,(H,23,24)/t16?,20-/m1/s1
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n/an/a 367n/an/an/an/an/an/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99358
PNG
(US8497281, 136 | US9120769, 69)
Show SMILES O=C(N1CCCC2[C@@H]1CCc1ccccc21)c1ccc2[nH]ccc2c1
Show InChI InChI=1S/C22H22N2O/c25-22(17-7-9-20-16(14-17)11-12-23-20)24-13-3-6-19-18-5-2-1-4-15(18)8-10-21(19)24/h1-2,4-5,7,9,11-12,14,19,21,23H,3,6,8,10,13H2/t19?,21-/m0/s1
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n/an/a 371n/an/an/an/an/an/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99409
PNG
(US8497281, 187 | US9120769, 120)
Show SMILES Cc1cc(ccc1O)C(=O)N1CCCC2[C@@H]1Cc1ccccc21
Show InChI InChI=1S/C20H21NO2/c1-13-11-15(8-9-19(13)22)20(23)21-10-4-7-17-16-6-3-2-5-14(16)12-18(17)21/h2-3,5-6,8-9,11,17-18,22H,4,7,10,12H2,1H3/t17?,18-/m0/s1
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n/an/a 383n/an/an/an/an/an/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM99423
PNG
(US8497281, 201 | US9120769, 134)
Show SMILES Oc1ccc(cc1)C(=O)N1CCCC2[C@@H]1Cc1ccccc21
Show InChI InChI=1S/C19H19NO2/c21-15-9-7-13(8-10-15)19(22)20-11-3-6-17-16-5-2-1-4-14(16)12-18(17)20/h1-2,4-5,7-10,17-18,21H,3,6,11-12H2/t17?,18-/m0/s1
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n/an/a 389n/an/an/an/an/an/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (human))
BDBM177590
PNG
(US9120769, 14)
Show SMILES COc1ccc2CC[C@H]3C(CCCN3C(=O)c3ccc4[nH]cnc4c3)c2c1
Show InChI InChI=1S/C22H23N3O2/c1-27-16-7-4-14-6-9-21-17(18(14)12-16)3-2-10-25(21)22(26)15-5-8-19-20(11-15)24-13-23-19/h4-5,7-8,11-13,17,21H,2-3,6,9-10H2,1H3,(H,23,24)/t17?,21-/m0/s1
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n/an/a 405n/an/an/an/an/an/a



Boehringer-Ingelheim International GmbH

US Patent


Assay Description
n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...


US Patent US9120769 (2015)


BindingDB Entry DOI: 10.7270/Q2XW4HK9
More data for this
Ligand-Target Pair
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