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Compile Data Set for Download or QSAR

Found 7 hits from Brain and Mind Research Institute   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50185957
PNG
(CHEMBL205767 | N-(2-isopropoxybenzyl)-N-(4-chloro-...)
Show SMILES CC(C)Oc1ccccc1CN(C(C)=O)c1ccc(Cl)cc1Oc1ccccc1
Show InChI InChI=1S/C24H24ClNO3/c1-17(2)28-23-12-8-7-9-19(23)16-26(18(3)27)22-14-13-20(25)15-24(22)29-21-10-5-4-6-11-21/h4-15,17H,16H2,1-3H3
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0.920n/an/an/an/an/an/an/an/a



Brain and Mind Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PK11195 from TSPO in rat cortex


J Med Chem 52: 581-92 (2009)


Article DOI: 10.1021/jm8011678
BindingDB Entry DOI: 10.7270/Q2222VP0
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50253713
PNG
(CHEMBL461828 | N-benzyl-2-(5-chloro-2-(4-chlorophe...)
Show SMILES CCN(Cc1ccccc1)C(=O)C(=O)c1c([nH]c2ccc(Cl)cc12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C25H20Cl2N2O2/c1-2-29(15-16-6-4-3-5-7-16)25(31)24(30)22-20-14-19(27)12-13-21(20)28-23(22)17-8-10-18(26)11-9-17/h3-14,28H,2,15H2,1H3
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3.33n/an/an/an/an/an/an/an/a



Brain and Mind Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PK11195 from TSPO in rat kidney membrane


J Med Chem 52: 581-92 (2009)


Article DOI: 10.1021/jm8011678
BindingDB Entry DOI: 10.7270/Q2222VP0
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50045877
PNG
(2-(2-(4-fluorophenyl)-1H-indol-3-yl)-N,N-dihexylac...)
Show SMILES CCCCCCN(CCCCCC)C(=O)Cc1c([nH]c2ccccc12)-c1ccc(F)cc1
Show InChI InChI=1S/C28H37FN2O/c1-3-5-7-11-19-31(20-12-8-6-4-2)27(32)21-25-24-13-9-10-14-26(24)30-28(25)22-15-17-23(29)18-16-22/h9-10,13-18,30H,3-8,11-12,19-21H2,1-2H3
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5n/an/an/an/an/an/an/an/a



Brain and Mind Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PK11195 from TSPO in rat cortex


J Med Chem 52: 581-92 (2009)


Article DOI: 10.1021/jm8011678
BindingDB Entry DOI: 10.7270/Q2222VP0
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50243007
PNG
(2-(2-(4-(2-Fluoroethoxy)phenyl)-5,7-dimethylpyrazo...)
Show SMILES CCN(CC)C(=O)Cc1c(nn2c(C)cc(C)nc12)-c1ccc(OCCF)cc1
Show InChI InChI=1S/C22H27FN4O2/c1-5-26(6-2)20(28)14-19-21(17-7-9-18(10-8-17)29-12-11-23)25-27-16(4)13-15(3)24-22(19)27/h7-10,13H,5-6,11-12,14H2,1-4H3
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7n/an/an/an/an/an/an/an/a



Brain and Mind Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PK11195 from TSPO in rat cortex


J Med Chem 52: 581-92 (2009)


Article DOI: 10.1021/jm8011678
BindingDB Entry DOI: 10.7270/Q2222VP0
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50255226
PNG
((7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihyd...)
Show SMILES CN(C)C(=O)Cc1nn(-c2ccccc2)c(=O)c2n(C)c3cc(Cl)ccc3c12
Show InChI InChI=1S/C21H19ClN4O2/c1-24(2)18(27)12-16-19-15-10-9-13(22)11-17(15)25(3)20(19)21(28)26(23-16)14-7-5-4-6-8-14/h4-11H,12H2,1-3H3
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n/an/an/a 3n/an/an/an/an/a



Brain and Mind Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]SSR180575 from TSPO in rat cortex


J Med Chem 52: 581-92 (2009)


Article DOI: 10.1021/jm8011678
BindingDB Entry DOI: 10.7270/Q2222VP0
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM22040
PNG
(4 -chlorodiazepam | 4' Cl-diazepam | 7-chloro-...)
Show SMILES CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3
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n/an/an/a 1.10n/an/an/an/an/a



Brain and Mind Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]Ro5-4864 from TSPO in rat kainate lesioned striatum


J Med Chem 52: 581-92 (2009)


Article DOI: 10.1021/jm8011678
BindingDB Entry DOI: 10.7270/Q2222VP0
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM22032
PNG
(1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoq...)
Show SMILES CCC(C)N(C)C(=O)c1cc2ccccc2c(n1)-c1ccccc1Cl
Show InChI InChI=1S/C21H21ClN2O/c1-4-14(2)24(3)21(25)19-13-15-9-5-6-10-16(15)20(23-19)17-11-7-8-12-18(17)22/h5-14H,4H2,1-3H3
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Article
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n/an/an/a 0.600n/an/an/an/an/a



Brain and Mind Research Institute

Curated by ChEMBL


Assay Description
Displacement of [3H]PK11195 from TSPO in rat cortex


J Med Chem 52: 581-92 (2009)


Article DOI: 10.1021/jm8011678
BindingDB Entry DOI: 10.7270/Q2222VP0
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)