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Compile Data Set for Download or QSAR

Found 116 hits from Bristol Myers Squibb Co.   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ghrelin receptor


(Homo sapiens (human))
BDBM50264552
PNG
((S)-2-(3-Chloro-phenoxy)-N-(2-methyl-benzyl)-N-(R)...)
Show SMILES C[C@H](Oc1cccc(Cl)c1)C(=O)N(C[C@H]1CCCN1)Cc1ccccc1C
Show InChI InChI=1S/C22H27ClN2O2/c1-16-7-3-4-8-18(16)14-25(15-20-10-6-12-24-20)22(26)17(2)27-21-11-5-9-19(23)13-21/h3-5,7-9,11,13,17,20,24H,6,10,12,14-15H2,1-2H3/t17-,20+/m0/s1
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30n/an/an/an/an/an/an/an/a



Bristol Myers Squibb Co.

Curated by ChEMBL


Assay Description
Binding affinity to GHSR (unknown origin)


Bioorg Med Chem Lett 18: 5083-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.07.120
BindingDB Entry DOI: 10.7270/Q2V69JF9
More data for this
Ligand-Target Pair
Ghrelin receptor


(Homo sapiens (human))
BDBM50264523
PNG
((S)-N-benzyl-2-(3-chlorophenoxy)-N-((R)-pyrrolidin...)
Show SMILES C[C@H](Oc1cccc(Cl)c1)C(=O)N(C[C@H]1CCCN1)Cc1ccccc1
Show InChI InChI=1S/C21H25ClN2O2/c1-16(26-20-11-5-9-18(22)13-20)21(25)24(15-19-10-6-12-23-19)14-17-7-3-2-4-8-17/h2-5,7-9,11,13,16,19,23H,6,10,12,14-15H2,1H3/t16-,19+/m0/s1
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30n/an/an/an/an/an/an/an/a



Bristol Myers Squibb Co.

Curated by ChEMBL


Assay Description
Binding affinity to GHSR (unknown origin)


Bioorg Med Chem Lett 18: 5083-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.07.120
BindingDB Entry DOI: 10.7270/Q2V69JF9
More data for this
Ligand-Target Pair
Ghrelin receptor


(Homo sapiens (human))
BDBM50264357
PNG
(2-(3-Chloro-phenoxy)-N-(2-methyl-benzyl)-N-(R)-1-p...)
Show SMILES CC(Oc1cccc(Cl)c1)C(=O)N(C[C@H]1CCCN1)Cc1ccccc1C
Show InChI InChI=1S/C22H27ClN2O2/c1-16-7-3-4-8-18(16)14-25(15-20-10-6-12-24-20)22(26)17(2)27-21-11-5-9-19(23)13-21/h3-5,7-9,11,13,17,20,24H,6,10,12,14-15H2,1-2H3/t17?,20-/m1/s1
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90n/an/an/an/an/an/an/an/a



Bristol Myers Squibb Co.

Curated by ChEMBL


Assay Description
Binding affinity to GHSR (unknown origin)


Bioorg Med Chem Lett 18: 5083-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.07.120
BindingDB Entry DOI: 10.7270/Q2V69JF9
More data for this
Ligand-Target Pair
Ghrelin receptor


(Homo sapiens (human))
BDBM50264521
PNG
((S)-N-(4-acetamidophenyl)-2-(3-chlorophenoxy)-N-((...)
Show SMILES C[C@H](Oc1cccc(Cl)c1)C(=O)N(C[C@H]1CCCN1)c1ccc(NC(C)=O)cc1
Show InChI InChI=1S/C22H26ClN3O3/c1-15(29-21-7-3-5-17(23)13-21)22(28)26(14-19-6-4-12-24-19)20-10-8-18(9-11-20)25-16(2)27/h3,5,7-11,13,15,19,24H,4,6,12,14H2,1-2H3,(H,25,27)/t15-,19+/m0/s1
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250n/an/an/an/an/an/an/an/a



Bristol Myers Squibb Co.

Curated by ChEMBL


Assay Description
Binding affinity to GHSR (unknown origin)


Bioorg Med Chem Lett 18: 5083-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.07.120
BindingDB Entry DOI: 10.7270/Q2V69JF9
More data for this
Ligand-Target Pair
Ghrelin receptor


(Homo sapiens (human))
BDBM50264486
PNG
(CHEMBL489401 | N-(4-acetamidophenyl)-2-(3-chloroph...)
Show SMILES CC(Oc1cccc(Cl)c1)C(=O)N(C[C@H]1CCCN1)c1ccc(NC(C)=O)cc1
Show InChI InChI=1S/C22H26ClN3O3/c1-15(29-21-7-3-5-17(23)13-21)22(28)26(14-19-6-4-12-24-19)20-10-8-18(9-11-20)25-16(2)27/h3,5,7-11,13,15,19,24H,4,6,12,14H2,1-2H3,(H,25,27)/t15?,19-/m1/s1
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260n/an/an/an/an/an/an/an/a



Bristol Myers Squibb Co.

Curated by ChEMBL


Assay Description
Binding affinity to GHSR (unknown origin)


Bioorg Med Chem Lett 18: 5083-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.07.120
BindingDB Entry DOI: 10.7270/Q2V69JF9
More data for this
Ligand-Target Pair
Ghrelin receptor


(Homo sapiens (human))
BDBM50264256
PNG
(CHEMBL489370 | N-benzyl-2-(3-chlorophenoxy)-N-((R)...)
Show SMILES CC(Oc1cccc(Cl)c1)C(=O)N(C[C@H]1CCCN1)Cc1ccccc1
Show InChI InChI=1S/C21H25ClN2O2/c1-16(26-20-11-5-9-18(22)13-20)21(25)24(15-19-10-6-12-23-19)14-17-7-3-2-4-8-17/h2-5,7-9,11,13,16,19,23H,6,10,12,14-15H2,1H3/t16?,19-/m1/s1
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300n/an/an/an/an/an/an/an/a



Bristol Myers Squibb Co.

Curated by ChEMBL


Assay Description
Binding affinity to GHSR (unknown origin)


Bioorg Med Chem Lett 18: 5083-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.07.120
BindingDB Entry DOI: 10.7270/Q2V69JF9
More data for this
Ligand-Target Pair
Ghrelin receptor


(Homo sapiens (human))
BDBM50264524
PNG
((R)-2-(3-Chloro-phenoxy)-N-(2-methyl-benzyl)-N-(R)...)
Show SMILES C[C@@H](Oc1cccc(Cl)c1)C(=O)N(C[C@H]1CCCN1)Cc1ccccc1C
Show InChI InChI=1S/C22H27ClN2O2/c1-16-7-3-4-8-18(16)14-25(15-20-10-6-12-24-20)22(26)17(2)27-21-11-5-9-19(23)13-21/h3-5,7-9,11,13,17,20,24H,6,10,12,14-15H2,1-2H3/t17-,20-/m1/s1
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2.20E+3n/an/an/an/an/an/an/an/a



Bristol Myers Squibb Co.

Curated by ChEMBL


Assay Description
Binding affinity to GHSR (unknown origin)


Bioorg Med Chem Lett 18: 5083-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.07.120
BindingDB Entry DOI: 10.7270/Q2V69JF9
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3 (KCa2.3)


(Homo sapiens (Human))
BDBM50260153
PNG
(Apamin | CHEMBL525408 | Octadecapeptide venom)
Show SMILES CC(C)C[C@@H]1NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CSSC[C@H](N)C(=O)N[C@@H](CC(N)=O)C(=O)N2)NC1=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)[C@@H](C)O
Show InChI InChI=1S/C79H131N31O24S4/c1-35(2)26-49-70(127)107-51-31-136-135-30-41(81)63(120)105-50(28-57(84)114)71(128)108-53(73(130)99-42(12-7-8-22-80)64(121)96-38(5)77(134)110-25-11-15-54(110)75(132)102-47(18-21-58(115)116)69(126)109-59(39(6)111)76(133)95-37(4)62(119)104-49)33-138-137-32-52(106-66(123)44(14-10-24-92-79(88)89)98-65(122)43(13-9-23-91-78(86)87)97-61(118)36(3)94-72(51)129)74(131)101-45(16-19-55(82)112)67(124)100-46(17-20-56(83)113)68(125)103-48(60(85)117)27-40-29-90-34-93-40/h29,34-39,41-54,59,111H,7-28,30-33,80-81H2,1-6H3,(H2,82,112)(H2,83,113)(H2,84,114)(H2,85,117)(H,90,93)(H,94,129)(H,95,133)(H,96,121)(H,97,118)(H,98,122)(H,99,130)(H,100,124)(H,101,131)(H,102,132)(H,103,125)(H,104,119)(H,105,120)(H,106,123)(H,107,127)(H,108,128)(H,109,126)(H,115,116)(H4,86,87,91)(H4,88,89,92)/t36-,37-,38-,39+,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,59-/m0/s1
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n/an/a 0.0640n/an/an/an/an/an/a



Bristol Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of Kca2.3 channel (unknown origin) expressed in HEK293 cells by electrophysiology assay


Bioorg Med Chem Lett 18: 5694-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.026
BindingDB Entry DOI: 10.7270/Q2TM79Z6
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3 (KCa2.3)


(Homo sapiens (Human))
BDBM50260153
PNG
(Apamin | CHEMBL525408 | Octadecapeptide venom)
Show SMILES CC(C)C[C@@H]1NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CSSC[C@H](N)C(=O)N[C@@H](CC(N)=O)C(=O)N2)NC1=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)[C@@H](C)O
Show InChI InChI=1S/C79H131N31O24S4/c1-35(2)26-49-70(127)107-51-31-136-135-30-41(81)63(120)105-50(28-57(84)114)71(128)108-53(73(130)99-42(12-7-8-22-80)64(121)96-38(5)77(134)110-25-11-15-54(110)75(132)102-47(18-21-58(115)116)69(126)109-59(39(6)111)76(133)95-37(4)62(119)104-49)33-138-137-32-52(106-66(123)44(14-10-24-92-79(88)89)98-65(122)43(13-9-23-91-78(86)87)97-61(118)36(3)94-72(51)129)74(131)101-45(16-19-55(82)112)67(124)100-46(17-20-56(83)113)68(125)103-48(60(85)117)27-40-29-90-34-93-40/h29,34-39,41-54,59,111H,7-28,30-33,80-81H2,1-6H3,(H2,82,112)(H2,83,113)(H2,84,114)(H2,85,117)(H,90,93)(H,94,129)(H,95,133)(H,96,121)(H,97,118)(H,98,122)(H,99,130)(H,100,124)(H,101,131)(H,102,132)(H,103,125)(H,104,119)(H,105,120)(H,106,123)(H,107,127)(H,108,128)(H,109,126)(H,115,116)(H4,86,87,91)(H4,88,89,92)/t36-,37-,38-,39+,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,59-/m0/s1
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n/an/a 0.0640n/an/an/an/an/an/a



Bristol Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of Kca2.3 channel expressed in HEK293 cells by electrophysiology assay


Bioorg Med Chem Lett 18: 5316-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.023
BindingDB Entry DOI: 10.7270/Q2N87BP1
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3 (KCa2.3)


(Homo sapiens (Human))
BDBM50260153
PNG
(Apamin | CHEMBL525408 | Octadecapeptide venom)
Show SMILES CC(C)C[C@@H]1NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CSSC[C@H](N)C(=O)N[C@@H](CC(N)=O)C(=O)N2)NC1=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)[C@@H](C)O
Show InChI InChI=1S/C79H131N31O24S4/c1-35(2)26-49-70(127)107-51-31-136-135-30-41(81)63(120)105-50(28-57(84)114)71(128)108-53(73(130)99-42(12-7-8-22-80)64(121)96-38(5)77(134)110-25-11-15-54(110)75(132)102-47(18-21-58(115)116)69(126)109-59(39(6)111)76(133)95-37(4)62(119)104-49)33-138-137-32-52(106-66(123)44(14-10-24-92-79(88)89)98-65(122)43(13-9-23-91-78(86)87)97-61(118)36(3)94-72(51)129)74(131)101-45(16-19-55(82)112)67(124)100-46(17-20-56(83)113)68(125)103-48(60(85)117)27-40-29-90-34-93-40/h29,34-39,41-54,59,111H,7-28,30-33,80-81H2,1-6H3,(H2,82,112)(H2,83,113)(H2,84,114)(H2,85,117)(H,90,93)(H,94,129)(H,95,133)(H,96,121)(H,97,118)(H,98,122)(H,99,130)(H,100,124)(H,101,131)(H,102,132)(H,103,125)(H,104,119)(H,105,120)(H,106,123)(H,107,127)(H,108,128)(H,109,126)(H,115,116)(H4,86,87,91)(H4,88,89,92)/t36-,37-,38-,39+,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,59-/m0/s1
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n/an/a 0.168n/an/an/an/an/an/a



Bristol Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assay


Bioorg Med Chem Lett 18: 5316-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.023
BindingDB Entry DOI: 10.7270/Q2N87BP1
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3 (KCa2.3)


(Homo sapiens (Human))
BDBM50260153
PNG
(Apamin | CHEMBL525408 | Octadecapeptide venom)
Show SMILES CC(C)C[C@@H]1NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CSSC[C@H](N)C(=O)N[C@@H](CC(N)=O)C(=O)N2)NC1=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)[C@@H](C)O
Show InChI InChI=1S/C79H131N31O24S4/c1-35(2)26-49-70(127)107-51-31-136-135-30-41(81)63(120)105-50(28-57(84)114)71(128)108-53(73(130)99-42(12-7-8-22-80)64(121)96-38(5)77(134)110-25-11-15-54(110)75(132)102-47(18-21-58(115)116)69(126)109-59(39(6)111)76(133)95-37(4)62(119)104-49)33-138-137-32-52(106-66(123)44(14-10-24-92-79(88)89)98-65(122)43(13-9-23-91-78(86)87)97-61(118)36(3)94-72(51)129)74(131)101-45(16-19-55(82)112)67(124)100-46(17-20-56(83)113)68(125)103-48(60(85)117)27-40-29-90-34-93-40/h29,34-39,41-54,59,111H,7-28,30-33,80-81H2,1-6H3,(H2,82,112)(H2,83,113)(H2,84,114)(H2,85,117)(H,90,93)(H,94,129)(H,95,133)(H,96,121)(H,97,118)(H,98,122)(H,99,130)(H,100,124)(H,101,131)(H,102,132)(H,103,125)(H,104,119)(H,105,120)(H,106,123)(H,107,127)(H,108,128)(H,109,126)(H,115,116)(H4,86,87,91)(H4,88,89,92)/t36-,37-,38-,39+,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,59-/m0/s1
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n/an/a 0.168n/an/an/an/an/an/a



Bristol Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of Kca2.3 channel (unknown origin) expressed in HEK293 cells by thallium flux assay


Bioorg Med Chem Lett 18: 5694-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.026
BindingDB Entry DOI: 10.7270/Q2TM79Z6
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1 (KCa2.1)


(Homo sapiens (Human))
BDBM50263327
PNG
(CHEMBL476339 | N-(4-methylpyridin-2-yl)-4-(pyridin...)
Show SMILES Cc1ccnc(Nc2nc(cs2)-c2ccccn2)c1
Show InChI InChI=1S/C14H12N4S/c1-10-5-7-16-13(8-10)18-14-17-12(9-19-14)11-4-2-3-6-15-11/h2-9H,1H3,(H,16,17,18)
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n/an/a 4n/an/an/an/an/an/a



Bristol Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of Kca2.1 channel expressed in HEK293 cells by thallium flux assay


Bioorg Med Chem Lett 18: 5316-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.023
BindingDB Entry DOI: 10.7270/Q2N87BP1
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3 (KCa2.3)


(Homo sapiens (Human))
BDBM50263327
PNG
(CHEMBL476339 | N-(4-methylpyridin-2-yl)-4-(pyridin...)
Show SMILES Cc1ccnc(Nc2nc(cs2)-c2ccccn2)c1
Show InChI InChI=1S/C14H12N4S/c1-10-5-7-16-13(8-10)18-14-17-12(9-19-14)11-4-2-3-6-15-11/h2-9H,1H3,(H,16,17,18)
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n/an/a 4n/an/an/an/an/an/a



Bristol Myers Squibb Co.

Curated by ChEMBL


Assay Description
Displacement of [125I]apamin from Kca2.3 channel expressed in HEK293 cells by scintillation proximity assay


Bioorg Med Chem Lett 18: 5316-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.023
BindingDB Entry DOI: 10.7270/Q2N87BP1
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 2


(Homo sapiens)
BDBM50263327
PNG
(CHEMBL476339 | N-(4-methylpyridin-2-yl)-4-(pyridin...)
Show SMILES Cc1ccnc(Nc2nc(cs2)-c2ccccn2)c1
Show InChI InChI=1S/C14H12N4S/c1-10-5-7-16-13(8-10)18-14-17-12(9-19-14)11-4-2-3-6-15-11/h2-9H,1H3,(H,16,17,18)
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n/an/a 11n/an/an/an/an/an/a



Bristol Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of Kca2.2 channel expressed in HEK293 cells by thallium flux assay


Bioorg Med Chem Lett 18: 5316-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.023
BindingDB Entry DOI: 10.7270/Q2N87BP1
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3 (KCa2.3)


(Homo sapiens (Human))
BDBM50264020
PNG
(CHEMBL489770 | GNF-PF-4773 | N-(4-(pyridin-2-yl)th...)
Show SMILES N(c1nc(cs1)-c1ccccn1)c1ccccn1
Show InChI InChI=1S/C13H10N4S/c1-3-7-14-10(5-1)11-9-18-13(16-11)17-12-6-2-4-8-15-12/h1-9H,(H,15,16,17)
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n/an/a 25n/an/an/an/an/an/a



Bristol Myers Squibb Co.

Curated by ChEMBL


Assay Description
Displacement of [125I]apamin from Kca2.3 channel expressed in HEK293 cells by scintillation proximity assay


Bioorg Med Chem Lett 18: 5316-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.023
BindingDB Entry DOI: 10.7270/Q2N87BP1
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1 (KCa2.1)


(Homo sapiens (Human))
BDBM50264020
PNG
(CHEMBL489770 | GNF-PF-4773 | N-(4-(pyridin-2-yl)th...)
Show SMILES N(c1nc(cs1)-c1ccccn1)c1ccccn1
Show InChI InChI=1S/C13H10N4S/c1-3-7-14-10(5-1)11-9-18-13(16-11)17-12-6-2-4-8-15-12/h1-9H,(H,15,16,17)
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n/an/a 43n/an/an/an/an/an/a



Bristol Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of Kca2.1 channel expressed in HEK293 cells by thallium flux assay


Bioorg Med Chem Lett 18: 5316-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.023
BindingDB Entry DOI: 10.7270/Q2N87BP1
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3 (KCa2.3)


(Homo sapiens (Human))
BDBM50263327
PNG
(CHEMBL476339 | N-(4-methylpyridin-2-yl)-4-(pyridin...)
Show SMILES Cc1ccnc(Nc2nc(cs2)-c2ccccn2)c1
Show InChI InChI=1S/C14H12N4S/c1-10-5-7-16-13(8-10)18-14-17-12(9-19-14)11-4-2-3-6-15-11/h2-9H,1H3,(H,16,17,18)
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n/an/a 56n/an/an/an/an/an/a



Bristol Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of Kca2.3 channel expressed in HEK293 cells by electrophysiology assay


Bioorg Med Chem Lett 18: 5316-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.023
BindingDB Entry DOI: 10.7270/Q2N87BP1
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 2


(Homo sapiens)
BDBM50263327
PNG
(CHEMBL476339 | N-(4-methylpyridin-2-yl)-4-(pyridin...)
Show SMILES Cc1ccnc(Nc2nc(cs2)-c2ccccn2)c1
Show InChI InChI=1S/C14H12N4S/c1-10-5-7-16-13(8-10)18-14-17-12(9-19-14)11-4-2-3-6-15-11/h2-9H,1H3,(H,16,17,18)
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n/an/a 59n/an/an/an/an/an/a



Bristol Myers Squibb Co.

Curated by ChEMBL


Assay Description
Displacement of [125I]apamin from Kca2.2 channel expressed in HEK293 cells


Bioorg Med Chem Lett 18: 5316-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.023
BindingDB Entry DOI: 10.7270/Q2N87BP1
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3 (KCa2.3)


(Homo sapiens (Human))
BDBM50263327
PNG
(CHEMBL476339 | N-(4-methylpyridin-2-yl)-4-(pyridin...)
Show SMILES Cc1ccnc(Nc2nc(cs2)-c2ccccn2)c1
Show InChI InChI=1S/C14H12N4S/c1-10-5-7-16-13(8-10)18-14-17-12(9-19-14)11-4-2-3-6-15-11/h2-9H,1H3,(H,16,17,18)
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n/an/a 59n/an/an/an/an/an/a



Bristol Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assay


Bioorg Med Chem Lett 18: 5316-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.023
BindingDB Entry DOI: 10.7270/Q2N87BP1
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 2


(Homo sapiens)
BDBM50264020
PNG
(CHEMBL489770 | GNF-PF-4773 | N-(4-(pyridin-2-yl)th...)
Show SMILES N(c1nc(cs1)-c1ccccn1)c1ccccn1
Show InChI InChI=1S/C13H10N4S/c1-3-7-14-10(5-1)11-9-18-13(16-11)17-12-6-2-4-8-15-12/h1-9H,(H,15,16,17)
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n/an/a 123n/an/an/an/an/an/a



Bristol Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of Kca2.2 channel expressed in HEK293 cells by thallium flux assay


Bioorg Med Chem Lett 18: 5316-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.023
BindingDB Entry DOI: 10.7270/Q2N87BP1
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3 (KCa2.3)


(Homo sapiens (Human))
BDBM50264020
PNG
(CHEMBL489770 | GNF-PF-4773 | N-(4-(pyridin-2-yl)th...)
Show SMILES N(c1nc(cs1)-c1ccccn1)c1ccccn1
Show InChI InChI=1S/C13H10N4S/c1-3-7-14-10(5-1)11-9-18-13(16-11)17-12-6-2-4-8-15-12/h1-9H,(H,15,16,17)
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n/an/a 290n/an/an/an/an/an/a



Bristol Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of Kca2.3 channel expressed in HEK293 cells by electrophysiology assay


Bioorg Med Chem Lett 18: 5316-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.023
BindingDB Entry DOI: 10.7270/Q2N87BP1
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1 (KCa2.1)


(Homo sapiens (Human))
BDBM50275960
PNG
(5-chloro-N-(thiophen-2-ylmethyl)pyrazolo[1,5-a]pyr...)
Show SMILES Clc1cc(NCc2cccs2)n2nccc2n1
Show InChI InChI=1S/C11H9ClN4S/c12-9-6-11(13-7-8-2-1-5-17-8)16-10(15-9)3-4-14-16/h1-6,13H,7H2
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n/an/a 300n/an/an/an/an/an/a



Bristol Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of Kca2.1 channel (unknown origin) expressed in HEK293 cells by thallium flux assay


Bioorg Med Chem Lett 18: 5694-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.026
BindingDB Entry DOI: 10.7270/Q2TM79Z6
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3 (KCa2.3)


(Homo sapiens (Human))
BDBM50275960
PNG
(5-chloro-N-(thiophen-2-ylmethyl)pyrazolo[1,5-a]pyr...)
Show SMILES Clc1cc(NCc2cccs2)n2nccc2n1
Show InChI InChI=1S/C11H9ClN4S/c12-9-6-11(13-7-8-2-1-5-17-8)16-10(15-9)3-4-14-16/h1-6,13H,7H2
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n/an/a 350n/an/an/an/an/an/a



Bristol Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of Kca2.3 channel (unknown origin) expressed in HEK293 cells by thallium flux assay


Bioorg Med Chem Lett 18: 5694-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.026
BindingDB Entry DOI: 10.7270/Q2TM79Z6
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 2


(Homo sapiens)
BDBM50275960
PNG
(5-chloro-N-(thiophen-2-ylmethyl)pyrazolo[1,5-a]pyr...)
Show SMILES Clc1cc(NCc2cccs2)n2nccc2n1
Show InChI InChI=1S/C11H9ClN4S/c12-9-6-11(13-7-8-2-1-5-17-8)16-10(15-9)3-4-14-16/h1-6,13H,7H2
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n/an/a 530n/an/an/an/an/an/a



Bristol Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of Kca2.2 channel (unknown origin) expressed in HEK293 cells by thallium flux assay


Bioorg Med Chem Lett 18: 5694-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.026
BindingDB Entry DOI: 10.7270/Q2TM79Z6
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 2


(Homo sapiens)
BDBM50264020
PNG
(CHEMBL489770 | GNF-PF-4773 | N-(4-(pyridin-2-yl)th...)
Show SMILES N(c1nc(cs1)-c1ccccn1)c1ccccn1
Show InChI InChI=1S/C13H10N4S/c1-3-7-14-10(5-1)11-9-18-13(16-11)17-12-6-2-4-8-15-12/h1-9H,(H,15,16,17)
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n/an/a 543n/an/an/an/an/an/a



Bristol Myers Squibb Co.

Curated by ChEMBL


Assay Description
Displacement of [125I]apamin from Kca2.2 channel expressed in HEK293 cells


Bioorg Med Chem Lett 18: 5316-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.023
BindingDB Entry DOI: 10.7270/Q2N87BP1
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3 (KCa2.3)


(Homo sapiens (Human))
BDBM50264020
PNG
(CHEMBL489770 | GNF-PF-4773 | N-(4-(pyridin-2-yl)th...)
Show SMILES N(c1nc(cs1)-c1ccccn1)c1ccccn1
Show InChI InChI=1S/C13H10N4S/c1-3-7-14-10(5-1)11-9-18-13(16-11)17-12-6-2-4-8-15-12/h1-9H,(H,15,16,17)
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n/an/a 543n/an/an/an/an/an/a



Bristol Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assay


Bioorg Med Chem Lett 18: 5316-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.023
BindingDB Entry DOI: 10.7270/Q2N87BP1
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3 (KCa2.3)


(Homo sapiens (Human))
BDBM50275960
PNG
(5-chloro-N-(thiophen-2-ylmethyl)pyrazolo[1,5-a]pyr...)
Show SMILES Clc1cc(NCc2cccs2)n2nccc2n1
Show InChI InChI=1S/C11H9ClN4S/c12-9-6-11(13-7-8-2-1-5-17-8)16-10(15-9)3-4-14-16/h1-6,13H,7H2
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n/an/a 580n/an/an/an/an/an/a



Bristol Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of Kca2.3 channel (unknown origin) expressed in HEK293 cells by electrophysiology assay


Bioorg Med Chem Lett 18: 5694-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.026
BindingDB Entry DOI: 10.7270/Q2TM79Z6
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3 (KCa2.3)


(Homo sapiens (Human))
BDBM50275958
PNG
((R)-5-chloro-N-(1-phenylethyl)pyrazolo[1,5-a]pyrim...)
Show SMILES C[C@@H](Nc1cc(Cl)nc2ccnn12)c1ccccc1
Show InChI InChI=1S/C14H13ClN4/c1-10(11-5-3-2-4-6-11)17-14-9-12(15)18-13-7-8-16-19(13)14/h2-10,17H,1H3/t10-/m1/s1
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n/an/a 1.00E+3n/an/an/an/an/an/a



Bristol Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of Kca2.3 channel (unknown origin) expressed in HEK293 cells by thallium flux assay


Bioorg Med Chem Lett 18: 5694-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.026
BindingDB Entry DOI: 10.7270/Q2TM79Z6
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3 (KCa2.3)


(Homo sapiens (Human))
BDBM50275792
PNG
(CHEMBL452406 | N-benzyl-5-chloropyrazolo[1,5-a]pyr...)
Show SMILES Clc1cc(NCc2ccccc2)n2nccc2n1
Show InChI InChI=1S/C13H11ClN4/c14-11-8-13(18-12(17-11)6-7-16-18)15-9-10-4-2-1-3-5-10/h1-8,15H,9H2
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n/an/a 1.10E+3n/an/an/an/an/an/a



Bristol Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of Kca2.3 channel (unknown origin) expressed in HEK293 cells by thallium flux assay


Bioorg Med Chem Lett 18: 5694-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.026
BindingDB Entry DOI: 10.7270/Q2TM79Z6
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 2


(Homo sapiens)
BDBM50275792
PNG
(CHEMBL452406 | N-benzyl-5-chloropyrazolo[1,5-a]pyr...)
Show SMILES Clc1cc(NCc2ccccc2)n2nccc2n1
Show InChI InChI=1S/C13H11ClN4/c14-11-8-13(18-12(17-11)6-7-16-18)15-9-10-4-2-1-3-5-10/h1-8,15H,9H2
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n/an/a 1.10E+3n/an/an/an/an/an/a



Bristol Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of Kca2.2 channel (unknown origin) expressed in HEK293 cells by thallium flux assay


Bioorg Med Chem Lett 18: 5694-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.026
BindingDB Entry DOI: 10.7270/Q2TM79Z6
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 1 (KCa2.1)


(Homo sapiens (Human))
BDBM50275792
PNG
(CHEMBL452406 | N-benzyl-5-chloropyrazolo[1,5-a]pyr...)
Show SMILES Clc1cc(NCc2ccccc2)n2nccc2n1
Show InChI InChI=1S/C13H11ClN4/c14-11-8-13(18-12(17-11)6-7-16-18)15-9-10-4-2-1-3-5-10/h1-8,15H,9H2
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n/an/a 1.19E+3n/an/an/an/an/an/a



Bristol Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of Kca2.1 channel (unknown origin) expressed in HEK293 cells by thallium flux assay


Bioorg Med Chem Lett 18: 5694-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.026
BindingDB Entry DOI: 10.7270/Q2TM79Z6
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3 (KCa2.3)


(Homo sapiens (Human))
BDBM50048403
PNG
(1,1'-(Deca-4,6-diyne-1,10-diyl)bis(4-amino-2-methy...)
Show SMILES Cc1cc(=[NH2+])c2ccccc2n1CCCCCCCCCCn1c(C)cc(=[NH2+])c2ccccc12
Show InChI InChI=1S/C30H38N4/c1-23-21-27(31)25-15-9-11-17-29(25)33(23)19-13-7-5-3-4-6-8-14-20-34-24(2)22-28(32)26-16-10-12-18-30(26)34/h9-12,15-18,21-22,31-32H,3-8,13-14,19-20H2,1-2H3/p+2
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n/an/a 1.30E+3n/an/an/an/an/an/a



Bristol Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assay


Bioorg Med Chem Lett 18: 5316-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.023
BindingDB Entry DOI: 10.7270/Q2N87BP1
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3 (KCa2.3)


(Homo sapiens (Human))
BDBM50275792
PNG
(CHEMBL452406 | N-benzyl-5-chloropyrazolo[1,5-a]pyr...)
Show SMILES Clc1cc(NCc2ccccc2)n2nccc2n1
Show InChI InChI=1S/C13H11ClN4/c14-11-8-13(18-12(17-11)6-7-16-18)15-9-10-4-2-1-3-5-10/h1-8,15H,9H2
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n/an/a 1.60E+3n/an/an/an/an/an/a



Bristol Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of Kca2.3 channel (unknown origin) expressed in HEK293 cells by electrophysiology assay


Bioorg Med Chem Lett 18: 5694-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.026
BindingDB Entry DOI: 10.7270/Q2TM79Z6
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3 (KCa2.3)


(Homo sapiens (Human))
BDBM50048403
PNG
(1,1'-(Deca-4,6-diyne-1,10-diyl)bis(4-amino-2-methy...)
Show SMILES Cc1cc(=[NH2+])c2ccccc2n1CCCCCCCCCCn1c(C)cc(=[NH2+])c2ccccc12
Show InChI InChI=1S/C30H38N4/c1-23-21-27(31)25-15-9-11-17-29(25)33(23)19-13-7-5-3-4-6-8-14-20-34-24(2)22-28(32)26-16-10-12-18-30(26)34/h9-12,15-18,21-22,31-32H,3-8,13-14,19-20H2,1-2H3/p+2
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n/an/a 2.00E+3n/an/an/an/an/an/a



Bristol Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of Kca2.3 channel expressed in HEK293 cells by electrophysiology assay


Bioorg Med Chem Lett 18: 5316-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.023
BindingDB Entry DOI: 10.7270/Q2N87BP1
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3 (KCa2.3)


(Homo sapiens (Human))
BDBM50275798
PNG
(5-chloro-N-(3-chlorobenzyl)pyrazolo[1,5-a]pyrimidi...)
Show SMILES Clc1cccc(CNc2cc(Cl)nc3ccnn23)c1
Show InChI InChI=1S/C13H10Cl2N4/c14-10-3-1-2-9(6-10)8-16-13-7-11(15)18-12-4-5-17-19(12)13/h1-7,16H,8H2
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n/an/a 5.20E+3n/an/an/an/an/an/a



Bristol Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of Kca2.3 channel (unknown origin) expressed in HEK293 cells by thallium flux assay


Bioorg Med Chem Lett 18: 5694-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.026
BindingDB Entry DOI: 10.7270/Q2TM79Z6
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3 (KCa2.3)


(Homo sapiens (Human))
BDBM50275959
PNG
(5-chloro-N-(1,2-diphenylethyl)pyrazolo[1,5-a]pyrim...)
Show SMILES Clc1cc(NC(Cc2ccccc2)c2ccccc2)n2nccc2n1
Show InChI InChI=1S/C20H17ClN4/c21-18-14-20(25-19(24-18)11-12-22-25)23-17(16-9-5-2-6-10-16)13-15-7-3-1-4-8-15/h1-12,14,17,23H,13H2
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n/an/a 7.50E+3n/an/an/an/an/an/a



Bristol Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of Kca2.3 channel (unknown origin) expressed in HEK293 cells by thallium flux assay


Bioorg Med Chem Lett 18: 5694-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.026
BindingDB Entry DOI: 10.7270/Q2TM79Z6
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3 (KCa2.3)


(Homo sapiens (Human))
BDBM50275853
PNG
(5-chloro-N-(3-nitrobenzyl)pyrazolo[1,5-a]pyrimidin...)
Show SMILES [O-][N+](=O)c1cccc(CNc2cc(Cl)nc3ccnn23)c1
Show InChI InChI=1S/C13H10ClN5O2/c14-11-7-13(18-12(17-11)4-5-16-18)15-8-9-2-1-3-10(6-9)19(20)21/h1-7,15H,8H2
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n/an/a 7.90E+3n/an/an/an/an/an/a



Bristol Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of Kca2.3 channel (unknown origin) expressed in HEK293 cells by thallium flux assay


Bioorg Med Chem Lett 18: 5694-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.026
BindingDB Entry DOI: 10.7270/Q2TM79Z6
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3 (KCa2.3)


(Homo sapiens (Human))
BDBM50275797
PNG
(5-chloro-N-(2-(trifluoromethoxy)benzyl)pyrazolo[1,...)
Show SMILES FC(F)(F)Oc1ccccc1CNc1cc(Cl)nc2ccnn12
Show InChI InChI=1S/C14H10ClF3N4O/c15-11-7-13(22-12(21-11)5-6-20-22)19-8-9-3-1-2-4-10(9)23-14(16,17)18/h1-7,19H,8H2
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n/an/a 1.00E+4n/an/an/an/an/an/a



Bristol Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of Kca2.3 channel (unknown origin) expressed in HEK293 cells by thallium flux assay


Bioorg Med Chem Lett 18: 5694-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.026
BindingDB Entry DOI: 10.7270/Q2TM79Z6
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3 (KCa2.3)


(Homo sapiens (Human))
BDBM50275850
PNG
(5-chloro-N-(3-methylbenzyl)pyrazolo[1,5-a]pyrimidi...)
Show SMILES Cc1cccc(CNc2cc(Cl)nc3ccnn23)c1
Show InChI InChI=1S/C14H13ClN4/c1-10-3-2-4-11(7-10)9-16-14-8-12(15)18-13-5-6-17-19(13)14/h2-8,16H,9H2,1H3
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n/an/a 1.07E+4n/an/an/an/an/an/a



Bristol Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of Kca2.3 channel (unknown origin) expressed in HEK293 cells by thallium flux assay


Bioorg Med Chem Lett 18: 5694-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.026
BindingDB Entry DOI: 10.7270/Q2TM79Z6
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3 (KCa2.3)


(Homo sapiens (Human))
BDBM50275852
PNG
(5-chloro-N-(3-(trifluoromethoxy)benzyl)pyrazolo[1,...)
Show SMILES FC(F)(F)Oc1cccc(CNc2cc(Cl)nc3ccnn23)c1
Show InChI InChI=1S/C14H10ClF3N4O/c15-11-7-13(22-12(21-11)4-5-20-22)19-8-9-2-1-3-10(6-9)23-14(16,17)18/h1-7,19H,8H2
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n/an/a 1.10E+4n/an/an/an/an/an/a



Bristol Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of Kca2.3 channel (unknown origin) expressed in HEK293 cells by thallium flux assay


Bioorg Med Chem Lett 18: 5694-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.026
BindingDB Entry DOI: 10.7270/Q2TM79Z6
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3 (KCa2.3)


(Homo sapiens (Human))
BDBM50275851
PNG
(5-chloro-N-(3-(trifluoromethyl)benzyl)pyrazolo[1,5...)
Show SMILES FC(F)(F)c1cccc(CNc2cc(Cl)nc3ccnn23)c1
Show InChI InChI=1S/C14H10ClF3N4/c15-11-7-13(22-12(21-11)4-5-20-22)19-8-9-2-1-3-10(6-9)14(16,17)18/h1-7,19H,8H2
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n/an/a 1.46E+4n/an/an/an/an/an/a



Bristol Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of Kca2.3 channel (unknown origin) expressed in HEK293 cells by thallium flux assay


Bioorg Med Chem Lett 18: 5694-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.026
BindingDB Entry DOI: 10.7270/Q2TM79Z6
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3 (KCa2.3)


(Homo sapiens (Human))
BDBM50275794
PNG
(5-chloro-N-(2-methylbenzyl)pyrazolo[1,5-a]pyrimidi...)
Show SMILES Cc1ccccc1CNc1cc(Cl)nc2ccnn12
Show InChI InChI=1S/C14H13ClN4/c1-10-4-2-3-5-11(10)9-16-14-8-12(15)18-13-6-7-17-19(13)14/h2-8,16H,9H2,1H3
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n/an/a 1.46E+4n/an/an/an/an/an/a



Bristol Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of Kca2.3 channel (unknown origin) expressed in HEK293 cells by thallium flux assay


Bioorg Med Chem Lett 18: 5694-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.026
BindingDB Entry DOI: 10.7270/Q2TM79Z6
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3 (KCa2.3)


(Homo sapiens (Human))
BDBM50275907
PNG
(5-chloro-N-(4-(trifluoromethoxy)benzyl)pyrazolo[1,...)
Show SMILES FC(F)(F)Oc1ccc(CNc2cc(Cl)nc3ccnn23)cc1
Show InChI InChI=1S/C14H10ClF3N4O/c15-11-7-13(22-12(21-11)5-6-20-22)19-8-9-1-3-10(4-2-9)23-14(16,17)18/h1-7,19H,8H2
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n/an/a 1.54E+4n/an/an/an/an/an/a



Bristol Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of Kca2.3 channel (unknown origin) expressed in HEK293 cells by thallium flux assay


Bioorg Med Chem Lett 18: 5694-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.026
BindingDB Entry DOI: 10.7270/Q2TM79Z6
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3 (KCa2.3)


(Homo sapiens (Human))
BDBM50275796
PNG
(5-chloro-N-(2-methoxybenzyl)pyrazolo[1,5-a]pyrimid...)
Show SMILES COc1ccccc1CNc1cc(Cl)nc2ccnn12
Show InChI InChI=1S/C14H13ClN4O/c1-20-11-5-3-2-4-10(11)9-16-14-8-12(15)18-13-6-7-17-19(13)14/h2-8,16H,9H2,1H3
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n/an/a 1.59E+4n/an/an/an/an/an/a



Bristol Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of Kca2.3 channel (unknown origin) expressed in HEK293 cells by thallium flux assay


Bioorg Med Chem Lett 18: 5694-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.026
BindingDB Entry DOI: 10.7270/Q2TM79Z6
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3 (KCa2.3)


(Homo sapiens (Human))
BDBM50275793
PNG
(5-chloro-N-(2-chlorobenzyl)pyrazolo[1,5-a]pyrimidi...)
Show SMILES Clc1cc(NCc2ccccc2Cl)n2nccc2n1
Show InChI InChI=1S/C13H10Cl2N4/c14-10-4-2-1-3-9(10)8-16-13-7-11(15)18-12-5-6-17-19(12)13/h1-7,16H,8H2
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n/an/a 1.91E+4n/an/an/an/an/an/a



Bristol Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of Kca2.3 channel (unknown origin) expressed in HEK293 cells by thallium flux assay


Bioorg Med Chem Lett 18: 5694-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.026
BindingDB Entry DOI: 10.7270/Q2TM79Z6
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3 (KCa2.3)


(Homo sapiens (Human))
BDBM50264075
PNG
(2-(4-(pyridin-2-yl)thiazol-2-yl)pyridine | CHEMBL5...)
Show SMILES c1sc(nc1-c1ccccn1)-c1ccccn1
Show InChI InChI=1S/C13H9N3S/c1-3-7-14-10(5-1)12-9-17-13(16-12)11-6-2-4-8-15-11/h1-9H
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n/an/a>3.00E+4n/an/an/an/an/an/a



Bristol Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assay


Bioorg Med Chem Lett 18: 5316-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.023
BindingDB Entry DOI: 10.7270/Q2N87BP1
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3 (KCa2.3)


(Homo sapiens (Human))
BDBM50264074
PNG
(CHEMBL510166 | N,4-Diphenylthiazol-2-amine)
Show SMILES N(c1nc(cs1)-c1ccccc1)c1ccccc1
Show InChI InChI=1S/C15H12N2S/c1-3-7-12(8-4-1)14-11-18-15(17-14)16-13-9-5-2-6-10-13/h1-11H,(H,16,17)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Bristol Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assay


Bioorg Med Chem Lett 18: 5316-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.023
BindingDB Entry DOI: 10.7270/Q2N87BP1
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3 (KCa2.3)


(Homo sapiens (Human))
BDBM50264073
PNG
(CHEMBL490592 | N-Phenyl-4-(2-pyridinyl)-1,3-thiazo...)
Show SMILES N(c1nc(cs1)-c1ccccn1)c1ccccc1
Show InChI InChI=1S/C14H11N3S/c1-2-6-11(7-3-1)16-14-17-13(10-18-14)12-8-4-5-9-15-12/h1-10H,(H,16,17)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Bristol Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assay


Bioorg Med Chem Lett 18: 5316-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.023
BindingDB Entry DOI: 10.7270/Q2N87BP1
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3 (KCa2.3)


(Homo sapiens (Human))
BDBM50264072
PNG
(2-(2-(pyridin-2-ylmethyl)thiazol-4-yl)pyridine | C...)
Show SMILES C(c1nc(cs1)-c1ccccn1)c1ccccn1
Show InChI InChI=1S/C14H11N3S/c1-3-7-15-11(5-1)9-14-17-13(10-18-14)12-6-2-4-8-16-12/h1-8,10H,9H2
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n/an/a>3.00E+4n/an/an/an/an/an/a



Bristol Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assay


Bioorg Med Chem Lett 18: 5316-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.023
BindingDB Entry DOI: 10.7270/Q2N87BP1
More data for this
Ligand-Target Pair
Small conductance calcium-activated potassium channel protein 3 (KCa2.3)


(Homo sapiens (Human))
BDBM50264071
PNG
(CHEMBL452409 | N-(4-(pyridin-4-yl)thiazol-2-yl)pyr...)
Show SMILES N(c1nc(cs1)-c1ccncc1)c1ccccn1
Show InChI InChI=1S/C13H10N4S/c1-2-6-15-12(3-1)17-13-16-11(9-18-13)10-4-7-14-8-5-10/h1-9H,(H,15,16,17)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Bristol Myers Squibb Co.

Curated by ChEMBL


Assay Description
Inhibition of Kca2.3 channel expressed in HEK293 cells by thallium flux assay


Bioorg Med Chem Lett 18: 5316-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.023
BindingDB Entry DOI: 10.7270/Q2N87BP1
More data for this
Ligand-Target Pair
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