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Compile Data Set for Download or QSAR

Found 240 hits from British Biotech Pharmaceuticals Limited   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Peptide deformylase mitochondrial


(Homo sapiens)
BDBM50121445
PNG
((S)-2-Mercaptomethyl-hexanoic acid [(S)-5-amino-1-...)
Show SMILES CCCC[C@H](CS)C(=O)N[C@@H](CCCCN)C(=O)Nc1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C19H30N4O4S/c1-2-3-6-14(13-28)18(24)22-17(7-4-5-12-20)19(25)21-15-8-10-16(11-9-15)23(26)27/h8-11,14,17,28H,2-7,12-13,20H2,1H3,(H,21,25)(H,22,24)/t14-,17+/m1/s1
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19n/an/an/an/an/an/an/an/a



British Biotech Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition of peptide deformylase, PDF.Fe of Escherichia coli


Bioorg Med Chem Lett 12: 3595-9 (2002)


Article DOI: 10.1016/s0960-894x(02)00790-4
BindingDB Entry DOI: 10.7270/Q2FJ2G4H
More data for this
Ligand-Target Pair
Peptide deformylase mitochondrial


(Homo sapiens)
BDBM50121442
PNG
(5-Guanidino-2-(2-mercaptomethyl-hexanoylamino)-pen...)
Show SMILES CCCCC(CS)C(=O)NC(CCCNC(N)=N)C(=O)OC
Show InChI InChI=1S/C14H28N4O3S/c1-3-4-6-10(9-22)12(19)18-11(13(20)21-2)7-5-8-17-14(15)16/h10-11,22H,3-9H2,1-2H3,(H,18,19)(H4,15,16,17)
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2.50E+3n/an/an/an/an/an/an/an/a



British Biotech Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition of peptide deformylase, PDF.Ni of Escherichia coli


Bioorg Med Chem Lett 12: 3595-9 (2002)


Article DOI: 10.1016/s0960-894x(02)00790-4
BindingDB Entry DOI: 10.7270/Q2FJ2G4H
More data for this
Ligand-Target Pair
Peptide deformylase


(Escherichia coli)
BDBM50137332
PNG
((R)-2-Cyclopentylmethyl-N-[(S)-1-(4,5-difluoro-2-m...)
Show SMILES CC(C)(C)[C@H](NC(=O)[C@H](CC1CCCC1)CN(O)C=O)C(=O)c1cc(F)c(F)cc1N1CCOCC1
Show InChI InChI=1S/C26H37F2N3O5/c1-26(2,3)24(29-25(34)18(15-31(35)16-32)12-17-6-4-5-7-17)23(33)19-13-20(27)21(28)14-22(19)30-8-10-36-11-9-30/h13-14,16-18,24,35H,4-12,15H2,1-3H3,(H,29,34)/t18-,24-/m1/s1
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n/an/a 0.5n/an/an/an/an/an/a



British Biotech Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibitory activity against Escherichia coli peptide deformylase (PDF) Nickel containing enzyme


Bioorg Med Chem Lett 14: 59-62 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.013
BindingDB Entry DOI: 10.7270/Q2T43SHT
More data for this
Ligand-Target Pair
Peptide deformylase


(Escherichia coli)
BDBM50137327
PNG
((R)-2-Cyclopentylmethyl-N-[(S)-1-(3-fluoro-4-morph...)
Show SMILES CC(C)(C)[C@H](NC(=O)[C@H](CC1CCCC1)CN(O)C=O)C(=O)c1ccc(N2CCOCC2)c(F)c1
Show InChI InChI=1S/C26H38FN3O5/c1-26(2,3)24(28-25(33)20(16-30(34)17-31)14-18-6-4-5-7-18)23(32)19-8-9-22(21(27)15-19)29-10-12-35-13-11-29/h8-9,15,17-18,20,24,34H,4-7,10-14,16H2,1-3H3,(H,28,33)/t20-,24-/m1/s1
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n/an/a 0.600n/an/an/an/an/an/a



British Biotech Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibitory activity against Escherichia coli peptide deformylase (PDF) Nickel containing enzyme


Bioorg Med Chem Lett 14: 59-62 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.013
BindingDB Entry DOI: 10.7270/Q2T43SHT
More data for this
Ligand-Target Pair
Peptide deformylase


(Escherichia coli)
BDBM50137324
PNG
((R)-2-Cyclopentylmethyl-N-{(S)-1-[4,5-difluoro-2-(...)
Show SMILES CC(C)(C)[C@H](NC(=O)[C@H](CC1CCCC1)CN(O)C=O)C(=O)c1cc(F)c(F)cc1N1CCC(O)CC1
Show InChI InChI=1S/C27H39F2N3O5/c1-27(2,3)25(30-26(36)18(15-32(37)16-33)12-17-6-4-5-7-17)24(35)20-13-21(28)22(29)14-23(20)31-10-8-19(34)9-11-31/h13-14,16-19,25,34,37H,4-12,15H2,1-3H3,(H,30,36)/t18-,25-/m1/s1
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n/an/a 1n/an/an/an/an/an/a



British Biotech Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibitory activity against Escherichia coli peptide deformylase (PDF) Nickel containing enzyme


Bioorg Med Chem Lett 14: 59-62 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.013
BindingDB Entry DOI: 10.7270/Q2T43SHT
More data for this
Ligand-Target Pair
Peptide deformylase


(Escherichia coli)
BDBM50137341
PNG
((R)-2-Cyclopentylmethyl-N-((S)-1-{3-fluoro-4-[4-(2...)
Show SMILES CC(C)(C)[C@H](NC(=O)[C@H](CC1CCCC1)CN(O)C=O)C(=O)c1ccc(N2CCN(CCO)CC2)c(F)c1
Show InChI InChI=1S/C28H43FN4O5/c1-28(2,3)26(30-27(37)22(18-33(38)19-35)16-20-6-4-5-7-20)25(36)21-8-9-24(23(29)17-21)32-12-10-31(11-13-32)14-15-34/h8-9,17,19-20,22,26,34,38H,4-7,10-16,18H2,1-3H3,(H,30,37)/t22-,26-/m1/s1
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n/an/a 1n/an/an/an/an/an/a



British Biotech Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibitory activity against Escherichia coli peptide deformylase (PDF) Nickel containing enzyme


Bioorg Med Chem Lett 14: 59-62 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.013
BindingDB Entry DOI: 10.7270/Q2T43SHT
More data for this
Ligand-Target Pair
Peptide deformylase


(Escherichia coli)
BDBM50137345
PNG
((R)-2-[(Formyl-hydroxy-amino)-methyl]-hexanoic aci...)
Show SMILES CCCC[C@H](CN(O)C=O)C(=O)N[C@H](C(=O)c1ccc(OC)cc1)C(C)(C)C
Show InChI InChI=1S/C21H32N2O5/c1-6-7-8-16(13-23(27)14-24)20(26)22-19(21(2,3)4)18(25)15-9-11-17(28-5)12-10-15/h9-12,14,16,19,27H,6-8,13H2,1-5H3,(H,22,26)/t16-,19-/m1/s1
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n/an/a 1n/an/an/an/an/an/a



British Biotech Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibitory activity against Escherichia coli peptide deformylase (PDF) Nickel containing enzyme


Bioorg Med Chem Lett 14: 59-62 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.013
BindingDB Entry DOI: 10.7270/Q2T43SHT
More data for this
Ligand-Target Pair
Peptide deformylase mitochondrial


(Homo sapiens)
BDBM50121444
PNG
((R)-2-Butyl-N*1*-((S)-1-dimethylcarbamoyl-2,2-dime...)
Show SMILES CCCC[C@H](CC(=O)NO)C(=O)N[C@H](C(=O)N(C)C)C(C)(C)C
Show InChI InChI=1S/C16H31N3O4/c1-7-8-9-11(10-12(20)18-23)14(21)17-13(16(2,3)4)15(22)19(5)6/h11,13,23H,7-10H2,1-6H3,(H,17,21)(H,18,20)/t11-,13-/m1/s1
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n/an/a 1n/an/an/an/an/an/a



British Biotech Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition of peptide deformylase, PDF.Ni of Escherichia coli


Bioorg Med Chem Lett 12: 3595-9 (2002)


Article DOI: 10.1016/s0960-894x(02)00790-4
BindingDB Entry DOI: 10.7270/Q2FJ2G4H
More data for this
Ligand-Target Pair
Peptide deformylase


(Escherichia coli)
BDBM50137334
PNG
((R)-2-Cyclopentylmethyl-N-((S)-2,2-dimethyl-1-{4-[...)
Show SMILES CC(C)(C)[C@H](NC(=O)[C@H](CC1CCCC1)CN(O)C=O)C(=O)c1ccc(cc1)N1CCN(CCN2CCOCC2)CC1
Show InChI InChI=1S/C32H51N5O5/c1-32(2,3)30(33-31(40)27(23-37(41)24-38)22-25-6-4-5-7-25)29(39)26-8-10-28(11-9-26)36-16-14-34(15-17-36)12-13-35-18-20-42-21-19-35/h8-11,24-25,27,30,41H,4-7,12-23H2,1-3H3,(H,33,40)/t27-,30-/m1/s1
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n/an/a 2n/an/an/an/an/an/a



British Biotech Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibitory activity against Escherichia coli peptide deformylase (PDF) Nickel containing enzyme


Bioorg Med Chem Lett 14: 59-62 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.013
BindingDB Entry DOI: 10.7270/Q2T43SHT
More data for this
Ligand-Target Pair
Peptide deformylase


(Escherichia coli)
BDBM50137326
PNG
((R)-2-Cyclopentylmethyl-3-(formyl-hydroxy-amino)-N...)
Show SMILES CC(C)(C)[C@H](NC(=O)[C@H](CC1CCCC1)CN(O)C=O)C(=O)c1ccc(cc1)N1CCN(CCO)CC1
Show InChI InChI=1S/C28H44N4O5/c1-28(2,3)26(29-27(36)23(19-32(37)20-34)18-21-6-4-5-7-21)25(35)22-8-10-24(11-9-22)31-14-12-30(13-15-31)16-17-33/h8-11,20-21,23,26,33,37H,4-7,12-19H2,1-3H3,(H,29,36)/t23-,26-/m1/s1
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n/an/a 2n/an/an/an/an/an/a



British Biotech Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibitory activity against Escherichia coli peptide deformylase (PDF) Nickel containing enzyme


Bioorg Med Chem Lett 14: 59-62 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.013
BindingDB Entry DOI: 10.7270/Q2T43SHT
More data for this
Ligand-Target Pair
Peptide deformylase


(Escherichia coli)
BDBM50137342
PNG
((R)-2-Cyclopentylmethyl-N-((S)-1-{4,5-difluoro-2-[...)
Show SMILES CC(C)(C)[C@H](NC(=O)[C@H](CC1CCCC1)CN(O)C=O)C(=O)c1cc(F)c(F)cc1N1CCN(CCO)CC1
Show InChI InChI=1S/C28H42F2N4O5/c1-28(2,3)26(31-27(38)20(17-34(39)18-36)14-19-6-4-5-7-19)25(37)21-15-22(29)23(30)16-24(21)33-10-8-32(9-11-33)12-13-35/h15-16,18-20,26,35,39H,4-14,17H2,1-3H3,(H,31,38)/t20-,26-/m1/s1
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n/an/a 2n/an/an/an/an/an/a



British Biotech Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibitory activity against Escherichia coli peptide deformylase (PDF) Nickel containing enzyme


Bioorg Med Chem Lett 14: 59-62 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.013
BindingDB Entry DOI: 10.7270/Q2T43SHT
More data for this
Ligand-Target Pair
Peptide deformylase


(Escherichia coli)
BDBM50137339
PNG
((R)-2-Cyclopentylmethyl-3-(formyl-hydroxy-amino)-N...)
Show SMILES CC(C)(C)[C@H](NC(=O)[C@H](CC1CCCC1)CN(O)C=O)C(=O)c1ccc(cc1)N1CCC(O)CC1
Show InChI InChI=1S/C27H41N3O5/c1-27(2,3)25(28-26(34)21(17-30(35)18-31)16-19-6-4-5-7-19)24(33)20-8-10-22(11-9-20)29-14-12-23(32)13-15-29/h8-11,18-19,21,23,25,32,35H,4-7,12-17H2,1-3H3,(H,28,34)/t21-,25-/m1/s1
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n/an/a 2n/an/an/an/an/an/a



British Biotech Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibitory activity against Escherichia coli peptide deformylase (PDF) Nickel containing enzyme


Bioorg Med Chem Lett 14: 59-62 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.013
BindingDB Entry DOI: 10.7270/Q2T43SHT
More data for this
Ligand-Target Pair
Peptide deformylase


(Escherichia coli)
BDBM50137329
PNG
((R)-2-Cyclopentylmethyl-N-((S)-1-{4,5-difluoro-2-[...)
Show SMILES CC(C)(C)[C@H](NC(=O)[C@H](CC1CCCC1)CN(O)C=O)C(=O)c1cc(F)c(F)cc1N1CCN(CCN2CCOCC2)CC1
Show InChI InChI=1S/C32H49F2N5O5/c1-32(2,3)30(35-31(42)24(21-39(43)22-40)18-23-6-4-5-7-23)29(41)25-19-26(33)27(34)20-28(25)38-12-10-36(11-13-38)8-9-37-14-16-44-17-15-37/h19-20,22-24,30,43H,4-18,21H2,1-3H3,(H,35,42)/t24-,30-/m1/s1
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n/an/a 2n/an/an/an/an/an/a



British Biotech Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibitory activity against Escherichia coli peptide deformylase (PDF) Nickel containing enzyme


Bioorg Med Chem Lett 14: 59-62 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.013
BindingDB Entry DOI: 10.7270/Q2T43SHT
More data for this
Ligand-Target Pair
Peptide deformylase


(Escherichia coli)
BDBM50137316
PNG
((R)-2-Cyclopentylmethyl-N-((S)-1-{4,5-difluoro-2-[...)
Show SMILES CC(C)(C)[C@H](NC(=O)[C@H](CC1CCCC1)CN(O)C=O)C(=O)c1cc(F)c(F)cc1N1CCN(CCN2CCCC2)CC1
Show InChI InChI=1S/C32H49F2N5O4/c1-32(2,3)30(35-31(42)24(21-39(43)22-40)18-23-8-4-5-9-23)29(41)25-19-26(33)27(34)20-28(25)38-16-14-37(15-17-38)13-12-36-10-6-7-11-36/h19-20,22-24,30,43H,4-18,21H2,1-3H3,(H,35,42)/t24-,30-/m1/s1
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n/an/a 2n/an/an/an/an/an/a



British Biotech Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibitory activity against Escherichia coli peptide deformylase (PDF) Nickel containing enzyme


Bioorg Med Chem Lett 14: 59-62 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.013
BindingDB Entry DOI: 10.7270/Q2T43SHT
More data for this
Ligand-Target Pair
Matrix Metalloproteinase-8 (MMP-8)


(Homo sapiens (human))
BDBM50081851
PNG
((2R,3R)-3-(cyclopentylmethyl)-2-((1-(dimethylamino...)
Show SMILES CN(C)c1cccc2c(cccc12)S(=O)(=O)N(C)C[C@@H]([C@@H](CC1CCCC1)C(=O)N1CCCCC1)C(=O)NO
Show InChI InChI=1S/C29H42N4O5S/c1-31(2)26-15-9-14-23-22(26)13-10-16-27(23)39(37,38)32(3)20-25(28(34)30-36)24(19-21-11-5-6-12-21)29(35)33-17-7-4-8-18-33/h9-10,13-16,21,24-25,36H,4-8,11-12,17-20H2,1-3H3,(H,30,34)/t24-,25+/m1/s1
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n/an/a 2n/an/an/an/an/an/a



British Biotech Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibition of HNC MMP-8


Bioorg Med Chem Lett 9: 2887-92 (1999)


Article DOI: 10.1016/s0960-894x(99)00494-1
BindingDB Entry DOI: 10.7270/Q25H7FGN
More data for this
Ligand-Target Pair
Peptide deformylase


(Escherichia coli)
BDBM50137314
PNG
((R)-2-Cyclopentylmethyl-N-{(S)-1-[3-fluoro-4-(4-hy...)
Show SMILES CC(C)(C)[C@H](NC(=O)[C@H](CC1CCCC1)CN(O)C=O)C(=O)c1ccc(N2CCC(O)CC2)c(F)c1
Show InChI InChI=1S/C27H40FN3O5/c1-27(2,3)25(29-26(35)20(16-31(36)17-32)14-18-6-4-5-7-18)24(34)19-8-9-23(22(28)15-19)30-12-10-21(33)11-13-30/h8-9,15,17-18,20-21,25,33,36H,4-7,10-14,16H2,1-3H3,(H,29,35)/t20-,25-/m1/s1
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British Biotech Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibitory activity against Escherichia coli peptide deformylase (PDF) Nickel containing enzyme


Bioorg Med Chem Lett 14: 59-62 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.013
BindingDB Entry DOI: 10.7270/Q2T43SHT
More data for this
Ligand-Target Pair
Peptide deformylase


(Escherichia coli)
BDBM50137328
PNG
((R)-2-Cyclopentylmethyl-3-(formyl-hydroxy-amino)-N...)
Show SMILES CC(C)(C)[C@H](NC(=O)[C@H](CC1CCCC1)CN(O)C=O)C(=O)c1ccc(O)cc1
Show InChI InChI=1S/C22H32N2O5/c1-22(2,3)20(19(27)16-8-10-18(26)11-9-16)23-21(28)17(13-24(29)14-25)12-15-6-4-5-7-15/h8-11,14-15,17,20,26,29H,4-7,12-13H2,1-3H3,(H,23,28)/t17-,20-/m1/s1
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British Biotech Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibitory activity against Escherichia coli peptide deformylase (PDF) Nickel containing enzyme


Bioorg Med Chem Lett 14: 59-62 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.013
BindingDB Entry DOI: 10.7270/Q2T43SHT
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(homo sapiens (human))
BDBM50081851
PNG
((2R,3R)-3-(cyclopentylmethyl)-2-((1-(dimethylamino...)
Show SMILES CN(C)c1cccc2c(cccc12)S(=O)(=O)N(C)C[C@@H]([C@@H](CC1CCCC1)C(=O)N1CCCCC1)C(=O)NO
Show InChI InChI=1S/C29H42N4O5S/c1-31(2)26-15-9-14-23-22(26)13-10-16-27(23)39(37,38)32(3)20-25(28(34)30-36)24(19-21-11-5-6-12-21)29(35)33-17-7-4-8-18-33/h9-10,13-16,21,24-25,36H,4-8,11-12,17-20H2,1-3H3,(H,30,34)/t24-,25+/m1/s1
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n/an/a 2n/an/an/an/an/an/a



British Biotech Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibition of HFC MMP-1


Bioorg Med Chem Lett 9: 2887-92 (1999)


Article DOI: 10.1016/s0960-894x(99)00494-1
BindingDB Entry DOI: 10.7270/Q25H7FGN
More data for this
Ligand-Target Pair
Collagenase


(Homo sapiens (human))
BDBM50063917
PNG
((2S,3R)-N(4)-[(2S)-3,3-dimethyl-1-(methylamino)-1-...)
Show SMILES CNC(=O)[C@@H](NC(=O)[C@H](CC(C)C)[C@H](O)C(=O)NO)C(C)(C)C
Show InChI InChI=1S/C15H29N3O5/c1-8(2)7-9(10(19)13(21)18-23)12(20)17-11(14(22)16-6)15(3,4)5/h8-11,19,23H,7H2,1-6H3,(H,16,22)(H,17,20)(H,18,21)/t9-,10+,11-/m1/s1
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n/an/a 2n/an/an/an/an/an/a



British Biotech Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibition of Coll-3 MMP-13


Bioorg Med Chem Lett 9: 2887-92 (1999)


Article DOI: 10.1016/s0960-894x(99)00494-1
BindingDB Entry DOI: 10.7270/Q25H7FGN
More data for this
Ligand-Target Pair
Matrix Metalloproteinase-8 (MMP-8)


(Homo sapiens (human))
BDBM50063917
PNG
((2S,3R)-N(4)-[(2S)-3,3-dimethyl-1-(methylamino)-1-...)
Show SMILES CNC(=O)[C@@H](NC(=O)[C@H](CC(C)C)[C@H](O)C(=O)NO)C(C)(C)C
Show InChI InChI=1S/C15H29N3O5/c1-8(2)7-9(10(19)13(21)18-23)12(20)17-11(14(22)16-6)15(3,4)5/h8-11,19,23H,7H2,1-6H3,(H,16,22)(H,17,20)(H,18,21)/t9-,10+,11-/m1/s1
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British Biotech Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibition of HNC MMP-8


Bioorg Med Chem Lett 9: 2887-92 (1999)


Article DOI: 10.1016/s0960-894x(99)00494-1
BindingDB Entry DOI: 10.7270/Q25H7FGN
More data for this
Ligand-Target Pair
Peptide deformylase


(Escherichia coli)
BDBM50137333
PNG
((R)-2-Cyclopentylmethyl-N-{(S)-1-[3-fluoro-4-((S)-...)
Show SMILES CC(C)(C)[C@H](NC(=O)[C@H](CC1CCCC1)CN(O)C=O)C(=O)c1ccc(N2CCC[C@H]2CO)c(F)c1
Show InChI InChI=1S/C27H40FN3O5/c1-27(2,3)25(29-26(35)20(15-30(36)17-33)13-18-7-4-5-8-18)24(34)19-10-11-23(22(28)14-19)31-12-6-9-21(31)16-32/h10-11,14,17-18,20-21,25,32,36H,4-9,12-13,15-16H2,1-3H3,(H,29,35)/t20-,21+,25-/m1/s1
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British Biotech Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibitory activity against Escherichia coli peptide deformylase (PDF) Nickel containing enzyme


Bioorg Med Chem Lett 14: 59-62 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.013
BindingDB Entry DOI: 10.7270/Q2T43SHT
More data for this
Ligand-Target Pair
Peptide deformylase


(Escherichia coli)
BDBM50137317
PNG
((R)-2-Cyclopentylmethyl-N-[(S)-2,2-dimethyl-1-(4-m...)
Show SMILES CC(C)(C)[C@H](NC(=O)[C@H](CC1CCCC1)CN(O)C=O)C(=O)c1ccc(cc1)N1CCOCC1
Show InChI InChI=1S/C26H39N3O5/c1-26(2,3)24(23(31)20-8-10-22(11-9-20)28-12-14-34-15-13-28)27-25(32)21(17-29(33)18-30)16-19-6-4-5-7-19/h8-11,18-19,21,24,33H,4-7,12-17H2,1-3H3,(H,27,32)/t21-,24-/m1/s1
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British Biotech Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibitory activity against Escherichia coli peptide deformylase (PDF) Nickel containing enzyme


Bioorg Med Chem Lett 14: 59-62 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.013
BindingDB Entry DOI: 10.7270/Q2T43SHT
More data for this
Ligand-Target Pair
Peptide deformylase


(Escherichia coli)
BDBM50137320
PNG
((R)-2-Cyclopentylmethyl-N-{(S)-1-[4,5-difluoro-2-(...)
Show SMILES CC(C)(C)[C@H](NC(=O)[C@H](CC1CCCC1)CN(O)C=O)C(=O)c1cc(F)c(F)cc1N1CCC[C@H]1CO
Show InChI InChI=1S/C27H39F2N3O5/c1-27(2,3)25(30-26(36)18(14-31(37)16-34)11-17-7-4-5-8-17)24(35)20-12-21(28)22(29)13-23(20)32-10-6-9-19(32)15-33/h12-13,16-19,25,33,37H,4-11,14-15H2,1-3H3,(H,30,36)/t18-,19+,25-/m1/s1
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British Biotech Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibitory activity against Escherichia coli peptide deformylase (PDF) Nickel containing enzyme


Bioorg Med Chem Lett 14: 59-62 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.013
BindingDB Entry DOI: 10.7270/Q2T43SHT
More data for this
Ligand-Target Pair
Peptide deformylase


(Escherichia coli)
BDBM50137346
PNG
((R)-2-Cyclopentylmethyl-N-[(S)-1-(4-fluoro-benzoyl...)
Show SMILES CC(C)(C)[C@H](NC(=O)[C@H](CC1CCCC1)CN(O)C=O)C(=O)c1ccc(F)cc1
Show InChI InChI=1S/C22H31FN2O4/c1-22(2,3)20(19(27)16-8-10-18(23)11-9-16)24-21(28)17(13-25(29)14-26)12-15-6-4-5-7-15/h8-11,14-15,17,20,29H,4-7,12-13H2,1-3H3,(H,24,28)/t17-,20-/m1/s1
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British Biotech Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibitory activity against Escherichia coli peptide deformylase (PDF) Nickel containing enzyme


Bioorg Med Chem Lett 14: 59-62 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.013
BindingDB Entry DOI: 10.7270/Q2T43SHT
More data for this
Ligand-Target Pair
Peptide deformylase


(Escherichia coli)
BDBM50137318
PNG
((R)-2-Cyclopentylmethyl-3-(formyl-hydroxy-amino)-N...)
Show SMILES COc1ccc(cc1)C(=O)[C@@H](NC(=O)[C@H](CC1CCCC1)CN(O)C=O)C(C)(C)C
Show InChI InChI=1S/C23H34N2O5/c1-23(2,3)21(20(27)17-9-11-19(30-4)12-10-17)24-22(28)18(14-25(29)15-26)13-16-7-5-6-8-16/h9-12,15-16,18,21,29H,5-8,13-14H2,1-4H3,(H,24,28)/t18-,21-/m1/s1
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British Biotech Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibitory activity against Escherichia coli peptide deformylase (PDF) Nickel containing enzyme


Bioorg Med Chem Lett 14: 59-62 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.013
BindingDB Entry DOI: 10.7270/Q2T43SHT
More data for this
Ligand-Target Pair
Peptide deformylase


(Escherichia coli)
BDBM50137323
PNG
((R)-2-Cyclopentylmethyl-N-((S)-2,2-dimethyl-1-{4-[...)
Show SMILES CC(C)(C)[C@H](NC(=O)[C@H](CC1CCCC1)CN(O)C=O)C(=O)c1ccc(cc1)N1CCN(CCN2CCCC2)CC1
Show InChI InChI=1S/C32H51N5O4/c1-32(2,3)30(33-31(40)27(23-37(41)24-38)22-25-8-4-5-9-25)29(39)26-10-12-28(13-11-26)36-20-18-35(19-21-36)17-16-34-14-6-7-15-34/h10-13,24-25,27,30,41H,4-9,14-23H2,1-3H3,(H,33,40)/t27-,30-/m1/s1
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British Biotech Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibitory activity against Escherichia coli peptide deformylase (PDF) Nickel containing enzyme


Bioorg Med Chem Lett 14: 59-62 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.013
BindingDB Entry DOI: 10.7270/Q2T43SHT
More data for this
Ligand-Target Pair
Matrix Metalloproteinase-8 (MMP-8)


(Homo sapiens (human))
BDBM50081869
PNG
((2R,3R)-3-(cyclopentylmethyl)-N-hydroxy-2-((4-meth...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(C)C[C@@H]([C@@H](CC1CCCC1)C(=O)N1CCCCC1)C(=O)NO
Show InChI InChI=1S/C24H37N3O6S/c1-26(34(31,32)20-12-10-19(33-2)11-13-20)17-22(23(28)25-30)21(16-18-8-4-5-9-18)24(29)27-14-6-3-7-15-27/h10-13,18,21-22,30H,3-9,14-17H2,1-2H3,(H,25,28)/t21-,22+/m1/s1
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British Biotech Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibition of HNC MMP-8


Bioorg Med Chem Lett 9: 2887-92 (1999)


Article DOI: 10.1016/s0960-894x(99)00494-1
BindingDB Entry DOI: 10.7270/Q25H7FGN
More data for this
Ligand-Target Pair
Matrix Metalloproteinase-8 (MMP-8)


(Homo sapiens (human))
BDBM50081866
PNG
((2R,3R)-3-(cyclopentylmethyl)-N-hydroxy-2-((4-meth...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(C)C[C@@H]([C@@H](CC1CCCC1)C(=O)N1CCOCC1)C(=O)NO
Show InChI InChI=1S/C23H35N3O7S/c1-25(34(30,31)19-9-7-18(32-2)8-10-19)16-21(22(27)24-29)20(15-17-5-3-4-6-17)23(28)26-11-13-33-14-12-26/h7-10,17,20-21,29H,3-6,11-16H2,1-2H3,(H,24,27)/t20-,21+/m1/s1
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British Biotech Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibition of HNC MMP-8


Bioorg Med Chem Lett 9: 2887-92 (1999)


Article DOI: 10.1016/s0960-894x(99)00494-1
BindingDB Entry DOI: 10.7270/Q25H7FGN
More data for this
Ligand-Target Pair
Peptide deformylase


(Escherichia coli)
BDBM50137319
PNG
((R)-2-[(Formyl-hydroxy-amino)-methyl]-hexanoic aci...)
Show SMILES CCCC[C@H](CN(O)C=O)C(=O)N[C@H](C(=O)c1ccccn1)C(C)(C)C
Show InChI InChI=1S/C19H29N3O4/c1-5-6-9-14(12-22(26)13-23)18(25)21-17(19(2,3)4)16(24)15-10-7-8-11-20-15/h7-8,10-11,13-14,17,26H,5-6,9,12H2,1-4H3,(H,21,25)/t14-,17-/m1/s1
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British Biotech Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibitory activity against Escherichia coli peptide deformylase (PDF) Nickel containing enzyme


Bioorg Med Chem Lett 14: 59-62 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.013
BindingDB Entry DOI: 10.7270/Q2T43SHT
More data for this
Ligand-Target Pair
Peptide deformylase


(Escherichia coli)
BDBM50137348
PNG
((R)-2-[(Formyl-hydroxy-amino)-methyl]-hexanoic aci...)
Show SMILES CCCC[C@H](CN(O)C=O)C(=O)N[C@H](C(=O)c1ccc(F)cc1)C(C)(C)C
Show InChI InChI=1S/C20H29FN2O4/c1-5-6-7-15(12-23(27)13-24)19(26)22-18(20(2,3)4)17(25)14-8-10-16(21)11-9-14/h8-11,13,15,18,27H,5-7,12H2,1-4H3,(H,22,26)/t15-,18-/m1/s1
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British Biotech Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibitory activity against Escherichia coli peptide deformylase (PDF) Nickel containing enzyme


Bioorg Med Chem Lett 14: 59-62 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.013
BindingDB Entry DOI: 10.7270/Q2T43SHT
More data for this
Ligand-Target Pair
Peptide deformylase


(Escherichia coli)
BDBM50137330
PNG
((R)-2-[(Formyl-hydroxy-amino)-methyl]-hexanoic aci...)
Show SMILES CCCC[C@H](CN(O)C=O)C(=O)N[C@H](C(=O)c1ccccc1)C(C)(C)C
Show InChI InChI=1S/C20H30N2O4/c1-5-6-10-16(13-22(26)14-23)19(25)21-18(20(2,3)4)17(24)15-11-8-7-9-12-15/h7-9,11-12,14,16,18,26H,5-6,10,13H2,1-4H3,(H,21,25)/t16-,18-/m1/s1
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British Biotech Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibitory activity against Escherichia coli peptide deformylase (PDF) Nickel containing enzyme


Bioorg Med Chem Lett 14: 59-62 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.013
BindingDB Entry DOI: 10.7270/Q2T43SHT
More data for this
Ligand-Target Pair
Matrix Metalloproteinase-8 (MMP-8)


(Homo sapiens (human))
BDBM50081859
PNG
((2R,3R)-2-((4-chloro-N-methylphenylsulfonamido)met...)
Show SMILES CN(C[C@@H]([C@@H](CC1CCCC1)C(=O)N1CCCCC1)C(=O)NO)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H34ClN3O5S/c1-26(33(31,32)19-11-9-18(24)10-12-19)16-21(22(28)25-30)20(15-17-7-3-4-8-17)23(29)27-13-5-2-6-14-27/h9-12,17,20-21,30H,2-8,13-16H2,1H3,(H,25,28)/t20-,21+/m1/s1
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British Biotech Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibition of HNC MMP-8


Bioorg Med Chem Lett 9: 2887-92 (1999)


Article DOI: 10.1016/s0960-894x(99)00494-1
BindingDB Entry DOI: 10.7270/Q25H7FGN
More data for this
Ligand-Target Pair
Peptide deformylase


(Escherichia coli)
BDBM50137347
PNG
((R)-2-[(Formyl-hydroxy-amino)-methyl]-hexanoic aci...)
Show SMILES CCCC[C@H](CN(O)C=O)C(=O)N[C@H](C(=O)c1ccc(NS(C)(=O)=O)cc1)C(C)(C)C
Show InChI InChI=1S/C21H33N3O6S/c1-6-7-8-16(13-24(28)14-25)20(27)22-19(21(2,3)4)18(26)15-9-11-17(12-10-15)23-31(5,29)30/h9-12,14,16,19,23,28H,6-8,13H2,1-5H3,(H,22,27)/t16-,19-/m1/s1
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British Biotech Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibitory activity against Escherichia coli peptide deformylase (PDF) Nickel containing enzyme


Bioorg Med Chem Lett 14: 59-62 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.013
BindingDB Entry DOI: 10.7270/Q2T43SHT
More data for this
Ligand-Target Pair
Peptide deformylase


(Escherichia coli)
BDBM50137313
PNG
((R)-2-[(Formyl-hydroxy-amino)-methyl]-hexanoic aci...)
Show SMILES CCCC[C@H](CN(O)C=O)C(=O)N[C@H](C(=O)c1cc2ccccc2o1)C(C)(C)C
Show InChI InChI=1S/C22H30N2O5/c1-5-6-9-16(13-24(28)14-25)21(27)23-20(22(2,3)4)19(26)18-12-15-10-7-8-11-17(15)29-18/h7-8,10-12,14,16,20,28H,5-6,9,13H2,1-4H3,(H,23,27)/t16-,20-/m1/s1
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British Biotech Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibitory activity against Escherichia coli peptide deformylase (PDF) Nickel containing enzyme


Bioorg Med Chem Lett 14: 59-62 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.013
BindingDB Entry DOI: 10.7270/Q2T43SHT
More data for this
Ligand-Target Pair
Matrix Metalloproteinase-8 (MMP-8)


(Homo sapiens (human))
BDBM50081852
PNG
((2R,3R)-3-(cyclopentylmethyl)-N-hydroxy-2-((N-meth...)
Show SMILES CN(C[C@@H]([C@@H](CC1CCCC1)C(=O)N1CCCCC1)C(=O)NO)S(=O)(=O)c1cccc2ccccc12
Show InChI InChI=1S/C27H37N3O5S/c1-29(36(34,35)25-15-9-13-21-12-5-6-14-22(21)25)19-24(26(31)28-33)23(18-20-10-3-4-11-20)27(32)30-16-7-2-8-17-30/h5-6,9,12-15,20,23-24,33H,2-4,7-8,10-11,16-19H2,1H3,(H,28,31)/t23-,24+/m1/s1
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British Biotech Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibition of HNC MMP-8


Bioorg Med Chem Lett 9: 2887-92 (1999)


Article DOI: 10.1016/s0960-894x(99)00494-1
BindingDB Entry DOI: 10.7270/Q25H7FGN
More data for this
Ligand-Target Pair
Peptide deformylase


(Escherichia coli)
BDBM50137335
PNG
((R)-N-[(S)-1-(Benzofuran-2-carbonyl)-2,2-dimethyl-...)
Show SMILES CC(C)(C)[C@H](NC(=O)[C@H](CC1CCCC1)CN(O)C=O)C(=O)c1cc2ccccc2o1
Show InChI InChI=1S/C24H32N2O5/c1-24(2,3)22(21(28)20-13-17-10-6-7-11-19(17)31-20)25-23(29)18(14-26(30)15-27)12-16-8-4-5-9-16/h6-7,10-11,13,15-16,18,22,30H,4-5,8-9,12,14H2,1-3H3,(H,25,29)/t18-,22-/m1/s1
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British Biotech Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibitory activity against Escherichia coli peptide deformylase (PDF) Nickel containing enzyme


Bioorg Med Chem Lett 14: 59-62 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.013
BindingDB Entry DOI: 10.7270/Q2T43SHT
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(homo sapiens (human))
BDBM50081871
PNG
((2R,3R)-3-(cyclopentylmethyl)-N-hydroxy-2-((N-meth...)
Show SMILES CC(C)S(=O)(=O)N(C)C[C@@H]([C@@H](CC1CCCC1)C(=O)N1CCCCC1)C(=O)NO
Show InChI InChI=1S/C20H37N3O5S/c1-15(2)29(27,28)22(3)14-18(19(24)21-26)17(13-16-9-5-6-10-16)20(25)23-11-7-4-8-12-23/h15-18,26H,4-14H2,1-3H3,(H,21,24)/t17-,18+/m1/s1
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n/an/a 5n/an/an/an/an/an/a



British Biotech Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibition of HFC MMP-1


Bioorg Med Chem Lett 9: 2887-92 (1999)


Article DOI: 10.1016/s0960-894x(99)00494-1
BindingDB Entry DOI: 10.7270/Q25H7FGN
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(homo sapiens (human))
BDBM50081860
PNG
((2R,3R)-3-(cyclopentylmethyl)-N-hydroxy-2-((N-meth...)
Show SMILES CN(C[C@@H]([C@@H](CC1CCCC1)C(=O)N1CCOCC1)C(=O)NO)S(C)(=O)=O
Show InChI InChI=1S/C17H31N3O6S/c1-19(27(2,24)25)12-15(16(21)18-23)14(11-13-5-3-4-6-13)17(22)20-7-9-26-10-8-20/h13-15,23H,3-12H2,1-2H3,(H,18,21)/t14-,15+/m1/s1
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n/an/a 5n/an/an/an/an/an/a



British Biotech Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibition of HFC MMP-1


Bioorg Med Chem Lett 9: 2887-92 (1999)


Article DOI: 10.1016/s0960-894x(99)00494-1
BindingDB Entry DOI: 10.7270/Q25H7FGN
More data for this
Ligand-Target Pair
Peptide deformylase


(Escherichia coli)
BDBM50137340
PNG
((R)-2-[(Formyl-hydroxy-amino)-methyl]-hexanoic aci...)
Show SMILES CCCC[C@H](CN(O)C=O)C(=O)N[C@H](C(=O)c1ccco1)C(C)(C)C
Show InChI InChI=1S/C18H28N2O5/c1-5-6-8-13(11-20(24)12-21)17(23)19-16(18(2,3)4)15(22)14-9-7-10-25-14/h7,9-10,12-13,16,24H,5-6,8,11H2,1-4H3,(H,19,23)/t13-,16-/m1/s1
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n/an/a 5n/an/an/an/an/an/a



British Biotech Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibitory activity against Escherichia coli peptide deformylase (PDF) Nickel containing enzyme


Bioorg Med Chem Lett 14: 59-62 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.013
BindingDB Entry DOI: 10.7270/Q2T43SHT
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(homo sapiens (human))
BDBM50063917
PNG
((2S,3R)-N(4)-[(2S)-3,3-dimethyl-1-(methylamino)-1-...)
Show SMILES CNC(=O)[C@@H](NC(=O)[C@H](CC(C)C)[C@H](O)C(=O)NO)C(C)(C)C
Show InChI InChI=1S/C15H29N3O5/c1-8(2)7-9(10(19)13(21)18-23)12(20)17-11(14(22)16-6)15(3,4)5/h8-11,19,23H,7H2,1-6H3,(H,16,22)(H,17,20)(H,18,21)/t9-,10+,11-/m1/s1
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n/an/a 5n/an/an/an/an/an/a



British Biotech Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibition of HFC MMP-1


Bioorg Med Chem Lett 9: 2887-92 (1999)


Article DOI: 10.1016/s0960-894x(99)00494-1
BindingDB Entry DOI: 10.7270/Q25H7FGN
More data for this
Ligand-Target Pair
Peptide deformylase


(Escherichia coli)
BDBM50137331
PNG
((R)-2-[(Formyl-hydroxy-amino)-methyl]-hexanoic aci...)
Show SMILES CCCC[C@H](CN(O)C=O)C(=O)N[C@H](C(=O)c1ccc(cc1)N1CCOCC1)C(C)(C)C
Show InChI InChI=1S/C24H37N3O5/c1-5-6-7-19(16-27(31)17-28)23(30)25-22(24(2,3)4)21(29)18-8-10-20(11-9-18)26-12-14-32-15-13-26/h8-11,17,19,22,31H,5-7,12-16H2,1-4H3,(H,25,30)/t19-,22-/m1/s1
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n/an/a 5n/an/an/an/an/an/a



British Biotech Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibitory activity against Escherichia coli peptide deformylase (PDF) Nickel containing enzyme


Bioorg Med Chem Lett 14: 59-62 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.013
BindingDB Entry DOI: 10.7270/Q2T43SHT
More data for this
Ligand-Target Pair
Collagenase


(homo sapiens (human))
BDBM50063917
PNG
((2S,3R)-N(4)-[(2S)-3,3-dimethyl-1-(methylamino)-1-...)
Show SMILES CNC(=O)[C@@H](NC(=O)[C@H](CC(C)C)[C@H](O)C(=O)NO)C(C)(C)C
Show InChI InChI=1S/C15H29N3O5/c1-8(2)7-9(10(19)13(21)18-23)12(20)17-11(14(22)16-6)15(3,4)5/h8-11,19,23H,7H2,1-6H3,(H,16,22)(H,17,20)(H,18,21)/t9-,10+,11-/m1/s1
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n/an/a 6n/an/an/an/an/an/a



British Biotech Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibition of Gel-A MMP-2


Bioorg Med Chem Lett 9: 2887-92 (1999)


Article DOI: 10.1016/s0960-894x(99)00494-1
BindingDB Entry DOI: 10.7270/Q25H7FGN
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(homo sapiens (human))
BDBM50081867
PNG
((2R,3R)-3-(cyclopentylmethyl)-N-hydroxy-2-((N-meth...)
Show SMILES CCS(=O)(=O)N(C)C[C@@H]([C@@H](CC1CCCC1)C(=O)N1CCCCC1)C(=O)NO
Show InChI InChI=1S/C19H35N3O5S/c1-3-28(26,27)21(2)14-17(18(23)20-25)16(13-15-9-5-6-10-15)19(24)22-11-7-4-8-12-22/h15-17,25H,3-14H2,1-2H3,(H,20,23)/t16-,17+/m1/s1
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n/an/a 6n/an/an/an/an/an/a



British Biotech Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibition of HFC MMP-1


Bioorg Med Chem Lett 9: 2887-92 (1999)


Article DOI: 10.1016/s0960-894x(99)00494-1
BindingDB Entry DOI: 10.7270/Q25H7FGN
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(homo sapiens (human))
BDBM50081865
PNG
((2R,3R)-2-((1-(dimethylamino)-N-methylnaphthalene-...)
Show SMILES CC(C)C[C@H]([C@H](CN(C)S(=O)(=O)c1cccc2c(cccc12)N(C)C)C(=O)NO)C(=O)N1CCCCC1
Show InChI InChI=1S/C27H40N4O5S/c1-19(2)17-22(27(33)31-15-7-6-8-16-31)23(26(32)28-34)18-30(5)37(35,36)25-14-10-11-20-21(25)12-9-13-24(20)29(3)4/h9-14,19,22-23,34H,6-8,15-18H2,1-5H3,(H,28,32)/t22-,23+/m1/s1
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n/an/a 6n/an/an/an/an/an/a



British Biotech Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibition of HFC MMP-1


Bioorg Med Chem Lett 9: 2887-92 (1999)


Article DOI: 10.1016/s0960-894x(99)00494-1
BindingDB Entry DOI: 10.7270/Q25H7FGN
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(homo sapiens (human))
BDBM50081852
PNG
((2R,3R)-3-(cyclopentylmethyl)-N-hydroxy-2-((N-meth...)
Show SMILES CN(C[C@@H]([C@@H](CC1CCCC1)C(=O)N1CCCCC1)C(=O)NO)S(=O)(=O)c1cccc2ccccc12
Show InChI InChI=1S/C27H37N3O5S/c1-29(36(34,35)25-15-9-13-21-12-5-6-14-22(21)25)19-24(26(31)28-33)23(18-20-10-3-4-11-20)27(32)30-16-7-2-8-17-30/h5-6,9,12-15,20,23-24,33H,2-4,7-8,10-11,16-19H2,1H3,(H,28,31)/t23-,24+/m1/s1
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n/an/a 6n/an/an/an/an/an/a



British Biotech Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibition of HFC MMP-1


Bioorg Med Chem Lett 9: 2887-92 (1999)


Article DOI: 10.1016/s0960-894x(99)00494-1
BindingDB Entry DOI: 10.7270/Q25H7FGN
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(homo sapiens (human))
BDBM50081872
PNG
((2R,3R)-3-(cyclopentylmethyl)-2-{[(dimethylsulfamo...)
Show SMILES CN(C)S(=O)(=O)N(C)C[C@@H]([C@@H](CC1CCCC1)C(=O)N1CCCCC1)C(=O)NO
Show InChI InChI=1S/C19H36N4O5S/c1-21(2)29(27,28)22(3)14-17(18(24)20-26)16(13-15-9-5-6-10-15)19(25)23-11-7-4-8-12-23/h15-17,26H,4-14H2,1-3H3,(H,20,24)/t16-,17+/m1/s1
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n/an/a 6n/an/an/an/an/an/a



British Biotech Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibition of HFC MMP-1


Bioorg Med Chem Lett 9: 2887-92 (1999)


Article DOI: 10.1016/s0960-894x(99)00494-1
BindingDB Entry DOI: 10.7270/Q25H7FGN
More data for this
Ligand-Target Pair
Peptide deformylase mitochondrial


(Homo sapiens)
BDBM50131303
PNG
((S)-2-[(R)-2-Cyclohexylmethyl-3-(formyl-hydroxy-am...)
Show SMILES CN(C)C(=O)[C@@H](NC(=O)[C@H](CC1CCCCC1)CN(O)C=O)C(C)(C)C
Show InChI InChI=1S/C19H35N3O4/c1-19(2,3)16(18(25)21(4)5)20-17(24)15(12-22(26)13-23)11-14-9-7-6-8-10-14/h13-16,26H,6-12H2,1-5H3,(H,20,24)/t15-,16-/m1/s1
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n/an/a 6n/an/an/an/an/an/a



British Biotech Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibition against Escherichia coli peptide deformylase


Bioorg Med Chem Lett 13: 2709-13 (2003)


Article DOI: 10.1016/s0960-894x(03)00532-8
BindingDB Entry DOI: 10.7270/Q2XW4J6S
More data for this
Ligand-Target Pair
Peptide deformylase


(Escherichia coli)
BDBM50137337
PNG
((R)-2-Cyclopentylmethyl-N-((S)-1-{3-fluoro-4-[4-(2...)
Show SMILES CC(C)(C)[C@H](NC(=O)[C@H](CC1CCCC1)CN(O)C=O)C(=O)c1ccc(N2CCN(CCN3CCOCC3)CC2)c(F)c1
Show InChI InChI=1S/C32H50FN5O5/c1-32(2,3)30(34-31(41)26(22-38(42)23-39)20-24-6-4-5-7-24)29(40)25-8-9-28(27(33)21-25)37-14-12-35(13-15-37)10-11-36-16-18-43-19-17-36/h8-9,21,23-24,26,30,42H,4-7,10-20,22H2,1-3H3,(H,34,41)/t26-,30-/m1/s1
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n/an/a 6n/an/an/an/an/an/a



British Biotech Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibitory activity against Escherichia coli peptide deformylase (PDF) Nickel containing enzyme


Bioorg Med Chem Lett 14: 59-62 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.013
BindingDB Entry DOI: 10.7270/Q2T43SHT
More data for this
Ligand-Target Pair
Peptide deformylase


(Escherichia coli)
BDBM50137317
PNG
((R)-2-Cyclopentylmethyl-N-[(S)-2,2-dimethyl-1-(4-m...)
Show SMILES CC(C)(C)[C@H](NC(=O)[C@H](CC1CCCC1)CN(O)C=O)C(=O)c1ccc(cc1)N1CCOCC1
Show InChI InChI=1S/C26H39N3O5/c1-26(2,3)24(23(31)20-8-10-22(11-9-20)28-12-14-34-15-13-28)27-25(32)21(17-29(33)18-30)16-19-6-4-5-7-19/h8-11,18-19,21,24,33H,4-7,12-17H2,1-3H3,(H,27,32)/t21-,24-/m1/s1
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n/an/a 6n/an/an/an/an/an/a



British Biotech Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibitory activity against Escherichia coli peptide deformylase (PDF) Nickel containing enzyme


Bioorg Med Chem Lett 14: 59-62 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.013
BindingDB Entry DOI: 10.7270/Q2T43SHT
More data for this
Ligand-Target Pair
Matrix metalloproteinase-1 (MMP1)


(homo sapiens (human))
BDBM50081864
PNG
((2R,3R)-3-(cyclopentylmethyl)-N-hydroxy-2-((N-meth...)
Show SMILES CN(C[C@@H]([C@@H](CC1CCCC1)C(=O)N1CCCCC1)C(=O)NO)S(C)(=O)=O
Show InChI InChI=1S/C18H33N3O5S/c1-20(27(2,25)26)13-16(17(22)19-24)15(12-14-8-4-5-9-14)18(23)21-10-6-3-7-11-21/h14-16,24H,3-13H2,1-2H3,(H,19,22)/t15-,16+/m1/s1
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n/an/a 6n/an/an/an/an/an/a



British Biotech Pharmaceuticals Limited

Curated by ChEMBL


Assay Description
Inhibition of HFC MMP-1


Bioorg Med Chem Lett 9: 2887-92 (1999)


Article DOI: 10.1016/s0960-894x(99)00494-1
BindingDB Entry DOI: 10.7270/Q25H7FGN
More data for this
Ligand-Target Pair
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