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Compile Data Set for Download or QSAR

Found 163 hits from Burroughs Wellcome Co.   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50042365
PNG
(CHEMBL117417 | [3-(2-Amino-6-oxo-1,6-dihydro-purin...)
Show SMILES Nc1nc2n(Cc3cccc(CSCP(O)(O)=O)c3)cnc2c(=O)[nH]1
Show InChI InChI=1S/C14H16N5O4PS/c15-14-17-12-11(13(20)18-14)16-7-19(12)5-9-2-1-3-10(4-9)6-25-8-24(21,22)23/h1-4,7H,5-6,8H2,(H2,21,22,23)(H3,15,17,18,20)
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1.10n/an/an/an/an/an/an/an/a



Burroughs Wellcome Co.

Curated by ChEMBL


Assay Description
Inhibition of purine nucleoside phosphorylase of human erythrocytes in xanthine oxidase-coupled assay


J Med Chem 36: 3455-63 (1993)


Article DOI: 10.1021/jm00074a029
BindingDB Entry DOI: 10.7270/Q2PR7V1V
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50033660
PNG
(CHEMBL269745 | {[5-(2-Amino-6-oxo-1,6-dihydro-puri...)
Show SMILES Nc1nc2n(CCCCCP(O)(=O)CP(O)(O)=O)cnc2c(=O)[nH]1
Show InChI InChI=1S/C11H19N5O6P2/c12-11-14-9-8(10(17)15-11)13-6-16(9)4-2-1-3-5-23(18,19)7-24(20,21)22/h6H,1-5,7H2,(H,18,19)(H2,20,21,22)(H3,12,14,15,17)
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3.10n/an/an/an/an/an/an/an/a



Burroughs Wellcome Co.

Curated by ChEMBL


Assay Description
Inhibition of human erythrocyte purine nucleoside phosphorylase (PNPase) in the presence of zinc chloride


J Med Chem 38: 1005-14 (1995)


Article DOI: 10.1021/jm00006a020
BindingDB Entry DOI: 10.7270/Q2FF3RDR
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50033663
PNG
(CHEMBL7319 | {[6-(2-Amino-6-oxo-1,6-dihydro-purin-...)
Show SMILES Nc1nc2n(CCCCCCP(O)(=O)CP(O)(O)=O)cnc2c(=O)[nH]1
Show InChI InChI=1S/C12H21N5O6P2/c13-12-15-10-9(11(18)16-12)14-7-17(10)5-3-1-2-4-6-24(19,20)8-25(21,22)23/h7H,1-6,8H2,(H,19,20)(H2,21,22,23)(H3,13,15,16,18)
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3.70n/an/an/an/an/an/an/an/a



Burroughs Wellcome Co.

Curated by ChEMBL


Assay Description
Inhibition of human erythrocyte purine nucleoside phosphorylase (PNPase) in the presence of zinc chloride


J Med Chem 38: 1005-14 (1995)


Article DOI: 10.1021/jm00006a020
BindingDB Entry DOI: 10.7270/Q2FF3RDR
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50033666
PNG
(2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methox...)
Show SMILES Nc1nc2n(COCCOP(O)(=O)OP(O)(O)=O)cnc2c(=O)[nH]1
Show InChI InChI=1S/C8H13N5O9P2/c9-8-11-6-5(7(14)12-8)10-3-13(6)4-20-1-2-21-24(18,19)22-23(15,16)17/h3H,1-2,4H2,(H,18,19)(H2,15,16,17)(H3,9,11,12,14)
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4.20n/an/an/an/an/an/an/an/a



Burroughs Wellcome Co.

Curated by ChEMBL


Assay Description
Inhibition of human erythrocyte purine nucleoside phosphorylase (PNPase) in the presence of zinc chloride


J Med Chem 38: 1005-14 (1995)


Article DOI: 10.1021/jm00006a020
BindingDB Entry DOI: 10.7270/Q2FF3RDR
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50033666
PNG
(2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methox...)
Show SMILES Nc1nc2n(COCCOP(O)(=O)OP(O)(O)=O)cnc2c(=O)[nH]1
Show InChI InChI=1S/C8H13N5O9P2/c9-8-11-6-5(7(14)12-8)10-3-13(6)4-20-1-2-21-24(18,19)22-23(15,16)17/h3H,1-2,4H2,(H,18,19)(H2,15,16,17)(H3,9,11,12,14)
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5.20n/an/an/an/an/an/an/an/a



Burroughs Wellcome Co.

Curated by ChEMBL


Assay Description
Inhibition of purine nucleoside phosphorylase of human erythrocytes in xanthine oxidase-coupled assay


J Med Chem 36: 3455-63 (1993)


Article DOI: 10.1021/jm00074a029
BindingDB Entry DOI: 10.7270/Q2PR7V1V
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50042370
PNG
(CHEMBL326595 | [3-(2-Amino-6-oxo-1,6-dihydro-purin...)
Show SMILES Nc1nc2n(Cc3cccc(COCP(O)(O)=O)c3)cnc2c(=O)[nH]1
Show InChI InChI=1S/C14H16N5O5P/c15-14-17-12-11(13(20)18-14)16-7-19(12)5-9-2-1-3-10(4-9)6-24-8-25(21,22)23/h1-4,7H,5-6,8H2,(H2,21,22,23)(H3,15,17,18,20)
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5.80n/an/an/an/an/an/an/an/a



Burroughs Wellcome Co.

Curated by ChEMBL


Assay Description
Inhibition of purine nucleoside phosphorylase of human erythrocytes in xanthine oxidase-coupled assay


J Med Chem 36: 3455-63 (1993)


Article DOI: 10.1021/jm00074a029
BindingDB Entry DOI: 10.7270/Q2PR7V1V
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50042364
PNG
(CHEMBL327010 | [2-(2-Amino-6-oxo-1,6-dihydro-purin...)
Show SMILES Nc1nc2n(Cc3ccccc3OCP(O)(O)=O)cnc2c(=O)[nH]1
Show InChI InChI=1S/C13H14N5O5P/c14-13-16-11-10(12(19)17-13)15-6-18(11)5-8-3-1-2-4-9(8)23-7-24(20,21)22/h1-4,6H,5,7H2,(H2,20,21,22)(H3,14,16,17,19)
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8.30n/an/an/an/an/an/an/an/a



Burroughs Wellcome Co.

Curated by ChEMBL


Assay Description
Inhibition of purine nucleoside phosphorylase of human erythrocytes in xanthine oxidase-coupled assay


J Med Chem 36: 3455-63 (1993)


Article DOI: 10.1021/jm00074a029
BindingDB Entry DOI: 10.7270/Q2PR7V1V
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM50009741
PNG
(1-Ethyl-phenoxathiine 10,10-dioxide | CHEMBL66225)
Show SMILES CCc1cccc2Oc3ccccc3S(=O)(=O)c12
Show InChI InChI=1S/C14H12O3S/c1-2-10-6-5-8-12-14(10)18(15,16)13-9-4-3-7-11(13)17-12/h3-9H,2H2,1H3
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10n/an/an/an/an/an/an/an/a



Burroughs Wellcome Co.

Curated by ChEMBL


Assay Description
In vitro binding affinity of the compound towards Monoamine Oxidase A in human


J Med Chem 34: 2931-3 (1991)


Article DOI: 10.1021/jm00113a039
BindingDB Entry DOI: 10.7270/Q28S4NW2
More data for this
Ligand-Target Pair
Monoamine oxidase


(Rattus norvegicus (rat))
BDBM50009741
PNG
(1-Ethyl-phenoxathiine 10,10-dioxide | CHEMBL66225)
Show SMILES CCc1cccc2Oc3ccccc3S(=O)(=O)c12
Show InChI InChI=1S/C14H12O3S/c1-2-10-6-5-8-12-14(10)18(15,16)13-9-4-3-7-11(13)17-12/h3-9H,2H2,1H3
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10n/an/an/an/an/an/an/an/a



Burroughs Wellcome Co.

Curated by ChEMBL


Assay Description
In vitro binding affinity of the compound towards Monoamine Oxidase A in rat


J Med Chem 34: 2931-3 (1991)


Article DOI: 10.1021/jm00113a039
BindingDB Entry DOI: 10.7270/Q28S4NW2
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50033666
PNG
(2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methox...)
Show SMILES Nc1nc2n(COCCOP(O)(=O)OP(O)(O)=O)cnc2c(=O)[nH]1
Show InChI InChI=1S/C8H13N5O9P2/c9-8-11-6-5(7(14)12-8)10-3-13(6)4-20-1-2-21-24(18,19)22-23(15,16)17/h3H,1-2,4H2,(H,18,19)(H2,15,16,17)(H3,9,11,12,14)
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10n/an/an/an/an/an/an/an/a



Burroughs Wellcome Co.

Curated by ChEMBL


Assay Description
In vitro inhibition of purine nucleoside phosphorylase isolated from human erythrocytes.


J Med Chem 39: 949-56 (1996)


Article DOI: 10.1021/jm950736k
BindingDB Entry DOI: 10.7270/Q2SN082H
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50033661
PNG
(CHEMBL7247 | {[7-(2-Amino-6-oxo-1,6-dihydro-purin-...)
Show SMILES Nc1nc2n(CCCCCCCP(O)(=O)CP(O)(O)=O)cnc2c(=O)[nH]1
Show InChI InChI=1S/C13H23N5O6P2/c14-13-16-11-10(12(19)17-13)15-8-18(11)6-4-2-1-3-5-7-25(20,21)9-26(22,23)24/h8H,1-7,9H2,(H,20,21)(H2,22,23,24)(H3,14,16,17,19)
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10n/an/an/an/an/an/an/an/a



Burroughs Wellcome Co.

Curated by ChEMBL


Assay Description
Inhibition of human erythrocyte purine nucleoside phosphorylase (PNPase) in the presence of zinc chloride


J Med Chem 38: 1005-14 (1995)


Article DOI: 10.1021/jm00006a020
BindingDB Entry DOI: 10.7270/Q2FF3RDR
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50033666
PNG
(2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methox...)
Show SMILES Nc1nc2n(COCCOP(O)(=O)OP(O)(O)=O)cnc2c(=O)[nH]1
Show InChI InChI=1S/C8H13N5O9P2/c9-8-11-6-5(7(14)12-8)10-3-13(6)4-20-1-2-21-24(18,19)22-23(15,16)17/h3H,1-2,4H2,(H,18,19)(H2,15,16,17)(H3,9,11,12,14)
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11n/an/an/an/an/an/an/an/a



Burroughs Wellcome Co.

Curated by ChEMBL


Assay Description
Inhibition of human erythrocyte purine nucleoside phosphorylase (PNPase) in the presence of ethylenediaminetetraacetic acid (Na2 EDTA)


J Med Chem 38: 1005-14 (1995)


Article DOI: 10.1021/jm00006a020
BindingDB Entry DOI: 10.7270/Q2FF3RDR
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50042372
PNG
(CHEMBL117127 | {3-[3-(2-Amino-6-oxo-1,6-dihydro-pu...)
Show SMILES Nc1nc2n(Cc3cccc(CCCP(O)(O)=O)c3)cnc2c(=O)[nH]1
Show InChI InChI=1S/C15H18N5O4P/c16-15-18-13-12(14(21)19-15)17-9-20(13)8-11-4-1-3-10(7-11)5-2-6-25(22,23)24/h1,3-4,7,9H,2,5-6,8H2,(H2,22,23,24)(H3,16,18,19,21)
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13n/an/an/an/an/an/an/an/a



Burroughs Wellcome Co.

Curated by ChEMBL


Assay Description
Inhibition of purine nucleoside phosphorylase of human erythrocytes in xanthine oxidase-coupled assay


J Med Chem 36: 3455-63 (1993)


Article DOI: 10.1021/jm00074a029
BindingDB Entry DOI: 10.7270/Q2PR7V1V
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50042363
PNG
(CHEMBL333946 | {2-[2-(2-Amino-6-oxo-1,6-dihydro-pu...)
Show SMILES Nc1nc2n(Cc3ccccc3CCP(O)(O)=O)cnc2c(=O)[nH]1
Show InChI InChI=1S/C14H16N5O4P/c15-14-17-12-11(13(20)18-14)16-8-19(12)7-10-4-2-1-3-9(10)5-6-24(21,22)23/h1-4,8H,5-7H2,(H2,21,22,23)(H3,15,17,18,20)
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35n/an/an/an/an/an/an/an/a



Burroughs Wellcome Co.

Curated by ChEMBL


Assay Description
Inhibition of purine nucleoside phosphorylase of human erythrocytes in xanthine oxidase-coupled assay


J Med Chem 36: 3455-63 (1993)


Article DOI: 10.1021/jm00074a029
BindingDB Entry DOI: 10.7270/Q2PR7V1V
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50049967
PNG
(CHEMBL174603 | [4-(5-Amino-7-oxo-6,7-dihydro-[1,2,...)
Show SMILES Nc1nc2n(COCCCCP(O)(O)=O)nnc2c(=O)[nH]1
Show InChI InChI=1S/C9H15N6O5P/c10-9-11-7-6(8(16)12-9)13-14-15(7)5-20-3-1-2-4-21(17,18)19/h1-5H2,(H2,17,18,19)(H3,10,11,12,16)
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48n/an/an/an/an/an/an/an/a



Burroughs Wellcome Co.

Curated by ChEMBL


Assay Description
In vitro inhibition of purine nucleoside phosphorylase isolated from human erythrocytes.


J Med Chem 39: 949-56 (1996)


Article DOI: 10.1021/jm950736k
BindingDB Entry DOI: 10.7270/Q2SN082H
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50049963
PNG
(CHEMBL368924 | [7-(6-Amino-4-oxo-4,5-dihydro-pyraz...)
Show SMILES Nc1nc2n(CCCCCCC(F)(F)P(O)(O)=O)ncc2c(=O)[nH]1
Show InChI InChI=1S/C12H18F2N5O4P/c13-12(14,24(21,22)23)5-3-1-2-4-6-19-9-8(7-16-19)10(20)18-11(15)17-9/h7H,1-6H2,(H2,21,22,23)(H3,15,17,18,20)
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49n/an/an/an/an/an/an/an/a



Burroughs Wellcome Co.

Curated by ChEMBL


Assay Description
In vitro inhibition of purine nucleoside phosphorylase isolated from human erythrocytes.


J Med Chem 39: 949-56 (1996)


Article DOI: 10.1021/jm950736k
BindingDB Entry DOI: 10.7270/Q2SN082H
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50049969
PNG
(CHEMBL172316 | Phosphoric acid mono-[4-(2-amino-6-...)
Show SMILES Nc1nc2n(COCCCCOP(O)(O)=O)cnc2c(=O)[nH]1
Show InChI InChI=1S/C10H16N5O6P/c11-10-13-8-7(9(16)14-10)12-5-15(8)6-20-3-1-2-4-21-22(17,18)19/h5H,1-4,6H2,(H2,17,18,19)(H3,11,13,14,16)
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51n/an/an/an/an/an/an/an/a



Burroughs Wellcome Co.

Curated by ChEMBL


Assay Description
In vitro inhibition of purine nucleoside phosphorylase isolated from human erythrocytes.


J Med Chem 39: 949-56 (1996)


Article DOI: 10.1021/jm950736k
BindingDB Entry DOI: 10.7270/Q2SN082H
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50049966
PNG
(CHEMBL177948 | [4-(2-Amino-6-oxo-1,6-dihydro-purin...)
Show SMILES Nc1nc2n(COCCCCP(O)(O)=O)cnc2c(=O)[nH]1
Show InChI InChI=1S/C10H16N5O5P/c11-10-13-8-7(9(16)14-10)12-5-15(8)6-20-3-1-2-4-21(17,18)19/h5H,1-4,6H2,(H2,17,18,19)(H3,11,13,14,16)
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56n/an/an/an/an/an/an/an/a



Burroughs Wellcome Co.

Curated by ChEMBL


Assay Description
In vitro inhibition of purine nucleoside phosphorylase isolated from human erythrocytes.


J Med Chem 39: 949-56 (1996)


Article DOI: 10.1021/jm950736k
BindingDB Entry DOI: 10.7270/Q2SN082H
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50049971
PNG
(CHEMBL177190 | [7-(2-Amino-6-oxo-1,6-dihydro-purin...)
Show SMILES Nc1nc2n(CCCCCCC(F)(F)P(O)(O)=O)cnc2c(=O)[nH]1
Show InChI InChI=1S/C12H18F2N5O4P/c13-12(14,24(21,22)23)5-3-1-2-4-6-19-7-16-8-9(19)17-11(15)18-10(8)20/h7H,1-6H2,(H2,21,22,23)(H3,15,17,18,20)
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57n/an/an/an/an/an/an/an/a



Burroughs Wellcome Co.

Curated by ChEMBL


Assay Description
In vitro inhibition of purine nucleoside phosphorylase isolated from human erythrocytes.


J Med Chem 39: 949-56 (1996)


Article DOI: 10.1021/jm950736k
BindingDB Entry DOI: 10.7270/Q2SN082H
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50042367
PNG
(CHEMBL325716 | {3-[3-(2-Amino-6-oxo-1,6-dihydro-pu...)
Show SMILES Nc1nc2n(Cc3cccc(C=CCP(O)(O)=O)c3)cnc2c(=O)[nH]1
Show InChI InChI=1S/C15H16N5O4P/c16-15-18-13-12(14(21)19-15)17-9-20(13)8-11-4-1-3-10(7-11)5-2-6-25(22,23)24/h1-5,7,9H,6,8H2,(H2,22,23,24)(H3,16,18,19,21)
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60n/an/an/an/an/an/an/an/a



Burroughs Wellcome Co.

Curated by ChEMBL


Assay Description
Inhibition of purine nucleoside phosphorylase of human erythrocytes in xanthine oxidase-coupled assay


J Med Chem 36: 3455-63 (1993)


Article DOI: 10.1021/jm00074a029
BindingDB Entry DOI: 10.7270/Q2PR7V1V
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50049954
PNG
(CHEMBL369052 | [5-(5-Amino-7-oxo-6,7-dihydro-[1,2,...)
Show SMILES Nc1nc2n(CCCCCP(O)(O)=O)nnc2c(=O)[nH]1
Show InChI InChI=1S/C9H15N6O4P/c10-9-11-7-6(8(16)12-9)13-14-15(7)4-2-1-3-5-20(17,18)19/h1-5H2,(H2,17,18,19)(H3,10,11,12,16)
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65n/an/an/an/an/an/an/an/a



Burroughs Wellcome Co.

Curated by ChEMBL


Assay Description
In vitro inhibition of purine nucleoside phosphorylase isolated from human erythrocytes.


J Med Chem 39: 949-56 (1996)


Article DOI: 10.1021/jm950736k
BindingDB Entry DOI: 10.7270/Q2SN082H
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50042369
PNG
(CHEMBL119243 | {2-[3-(2-Amino-6-oxo-1,6-dihydro-pu...)
Show SMILES Nc1nc2n(Cc3cccc(COCCP(O)(O)=O)c3)cnc2c(=O)[nH]1
Show InChI InChI=1S/C15H18N5O5P/c16-15-18-13-12(14(21)19-15)17-9-20(13)7-10-2-1-3-11(6-10)8-25-4-5-26(22,23)24/h1-3,6,9H,4-5,7-8H2,(H2,22,23,24)(H3,16,18,19,21)
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69n/an/an/an/an/an/an/an/a



Burroughs Wellcome Co.

Curated by ChEMBL


Assay Description
Inhibition of purine nucleoside phosphorylase of human erythrocytes in xanthine oxidase-coupled assay


J Med Chem 36: 3455-63 (1993)


Article DOI: 10.1021/jm00074a029
BindingDB Entry DOI: 10.7270/Q2PR7V1V
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50049959
PNG
(CHEMBL173142 | [5-(5-Amino-7-oxo-6,7-dihydro-[1,2,...)
Show SMILES Nc1nc2n(COCCCCCP(O)(O)=O)nnc2c(=O)[nH]1
Show InChI InChI=1S/C10H17N6O5P/c11-10-12-8-7(9(17)13-10)14-15-16(8)6-21-4-2-1-3-5-22(18,19)20/h1-6H2,(H2,18,19,20)(H3,11,12,13,17)
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96n/an/an/an/an/an/an/an/a



Burroughs Wellcome Co.

Curated by ChEMBL


Assay Description
In vitro inhibition of purine nucleoside phosphorylase isolated from human erythrocytes.


J Med Chem 39: 949-56 (1996)


Article DOI: 10.1021/jm950736k
BindingDB Entry DOI: 10.7270/Q2SN082H
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50033664
PNG
(CHEMBL7068 | {[4-(2-Amino-6-oxo-1,6-dihydro-purin-...)
Show SMILES Nc1nc2n(CCCCP(O)(=O)CP(O)(O)=O)cnc2c(=O)[nH]1
Show InChI InChI=1S/C10H17N5O6P2/c11-10-13-8-7(9(16)14-10)12-5-15(8)3-1-2-4-22(17,18)6-23(19,20)21/h5H,1-4,6H2,(H,17,18)(H2,19,20,21)(H3,11,13,14,16)
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100n/an/an/an/an/an/an/an/a



Burroughs Wellcome Co.

Curated by ChEMBL


Assay Description
Inhibition of human erythrocyte purine nucleoside phosphorylase (PNPase) in the presence of zinc chloride


J Med Chem 38: 1005-14 (1995)


Article DOI: 10.1021/jm00006a020
BindingDB Entry DOI: 10.7270/Q2FF3RDR
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50042362
PNG
(CHEMBL331133 | [2-(2-Amino-6-oxo-1,6-dihydro-purin...)
Show SMILES Nc1nc2n(Cc3ccccc3COCP(O)(O)=O)cnc2c(=O)[nH]1
Show InChI InChI=1S/C14H16N5O5P/c15-14-17-12-11(13(20)18-14)16-7-19(12)5-9-3-1-2-4-10(9)6-24-8-25(21,22)23/h1-4,7H,5-6,8H2,(H2,21,22,23)(H3,15,17,18,20)
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150n/an/an/an/an/an/an/an/a



Burroughs Wellcome Co.

Curated by ChEMBL


Assay Description
Inhibition of purine nucleoside phosphorylase of human erythrocytes in xanthine oxidase-coupled assay


J Med Chem 36: 3455-63 (1993)


Article DOI: 10.1021/jm00074a029
BindingDB Entry DOI: 10.7270/Q2PR7V1V
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50049972
PNG
(CHEMBL176448 | [5-(2-Amino-6-oxo-1,6-dihydro-purin...)
Show SMILES Nc1nc2n(COCCCCCP(O)(O)=O)cnc2c(=O)[nH]1
Show InChI InChI=1S/C11H18N5O5P/c12-11-14-9-8(10(17)15-11)13-6-16(9)7-21-4-2-1-3-5-22(18,19)20/h6H,1-5,7H2,(H2,18,19,20)(H3,12,14,15,17)
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160n/an/an/an/an/an/an/an/a



Burroughs Wellcome Co.

Curated by ChEMBL


Assay Description
In vitro inhibition of purine nucleoside phosphorylase isolated from human erythrocytes.


J Med Chem 39: 949-56 (1996)


Article DOI: 10.1021/jm950736k
BindingDB Entry DOI: 10.7270/Q2SN082H
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50049957
PNG
(CHEMBL366963 | [6-(5-Amino-7-oxo-6,7-dihydro-[1,2,...)
Show SMILES Nc1nc2n(COCCCCCCP(O)(O)=O)nnc2c(=O)[nH]1
Show InChI InChI=1S/C11H19N6O5P/c12-11-13-9-8(10(18)14-11)15-16-17(9)7-22-5-3-1-2-4-6-23(19,20)21/h1-7H2,(H2,19,20,21)(H3,12,13,14,18)
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190n/an/an/an/an/an/an/an/a



Burroughs Wellcome Co.

Curated by ChEMBL


Assay Description
In vitro inhibition of purine nucleoside phosphorylase isolated from human erythrocytes.


J Med Chem 39: 949-56 (1996)


Article DOI: 10.1021/jm950736k
BindingDB Entry DOI: 10.7270/Q2SN082H
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50049968
PNG
(CHEMBL177945 | [6-(2-Amino-6-oxo-1,6-dihydro-purin...)
Show SMILES Nc1nc2n(COCCCCCCP(O)(O)=O)cnc2c(=O)[nH]1
Show InChI InChI=1S/C12H20N5O5P/c13-12-15-10-9(11(18)16-12)14-7-17(10)8-22-5-3-1-2-4-6-23(19,20)21/h7H,1-6,8H2,(H2,19,20,21)(H3,13,15,16,18)
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220n/an/an/an/an/an/an/an/a



Burroughs Wellcome Co.

Curated by ChEMBL


Assay Description
In vitro inhibition of purine nucleoside phosphorylase isolated from human erythrocytes.


J Med Chem 39: 949-56 (1996)


Article DOI: 10.1021/jm950736k
BindingDB Entry DOI: 10.7270/Q2SN082H
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50049955
PNG
(CHEMBL175362 | [5-(6-Amino-4-oxo-4,5-dihydro-pyraz...)
Show SMILES Nc1nc2n(COCCCCCP(O)(O)=O)ncc2c(=O)[nH]1
Show InChI InChI=1S/C11H18N5O5P/c12-11-14-9-8(10(17)15-11)6-13-16(9)7-21-4-2-1-3-5-22(18,19)20/h6H,1-5,7H2,(H2,18,19,20)(H3,12,14,15,17)
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230n/an/an/an/an/an/an/an/a



Burroughs Wellcome Co.

Curated by ChEMBL


Assay Description
In vitro inhibition of purine nucleoside phosphorylase isolated from human erythrocytes.


J Med Chem 39: 949-56 (1996)


Article DOI: 10.1021/jm950736k
BindingDB Entry DOI: 10.7270/Q2SN082H
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50049960
PNG
(CHEMBL368064 | [6-(5-Amino-7-oxo-6,7-dihydro-[1,2,...)
Show SMILES Nc1nc2n(CCCCCCP(O)(O)=O)nnc2c(=O)[nH]1
Show InChI InChI=1S/C10H17N6O4P/c11-10-12-8-7(9(17)13-10)14-15-16(8)5-3-1-2-4-6-21(18,19)20/h1-6H2,(H2,18,19,20)(H3,11,12,13,17)
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360n/an/an/an/an/an/an/an/a



Burroughs Wellcome Co.

Curated by ChEMBL


Assay Description
In vitro inhibition of purine nucleoside phosphorylase isolated from human erythrocytes.


J Med Chem 39: 949-56 (1996)


Article DOI: 10.1021/jm950736k
BindingDB Entry DOI: 10.7270/Q2SN082H
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50033663
PNG
(CHEMBL7319 | {[6-(2-Amino-6-oxo-1,6-dihydro-purin-...)
Show SMILES Nc1nc2n(CCCCCCP(O)(=O)CP(O)(O)=O)cnc2c(=O)[nH]1
Show InChI InChI=1S/C12H21N5O6P2/c13-12-15-10-9(11(18)16-12)14-7-17(10)5-3-1-2-4-6-24(19,20)8-25(21,22)23/h7H,1-6,8H2,(H,19,20)(H2,21,22,23)(H3,13,15,16,18)
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390n/an/an/an/an/an/an/an/a



Burroughs Wellcome Co.

Curated by ChEMBL


Assay Description
Inhibition of human erythrocyte purine nucleoside phosphorylase (PNPase) in the presence of ethylenediaminetetraacetic acid (Na2 EDTA)


J Med Chem 38: 1005-14 (1995)


Article DOI: 10.1021/jm00006a020
BindingDB Entry DOI: 10.7270/Q2FF3RDR
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50049961
PNG
(CHEMBL354409 | [8-(2-Amino-6-oxo-1,6-dihydro-purin...)
Show SMILES Nc1nc2n(CCCCCCCCP(O)(O)=O)cnc2c(=O)[nH]1
Show InChI InChI=1S/C13H22N5O4P/c14-13-16-11-10(12(19)17-13)15-9-18(11)7-5-3-1-2-4-6-8-23(20,21)22/h9H,1-8H2,(H2,20,21,22)(H3,14,16,17,19)
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390n/an/an/an/an/an/an/an/a



Burroughs Wellcome Co.

Curated by ChEMBL


Assay Description
In vitro inhibition of purine nucleoside phosphorylase isolated from human erythrocytes.


J Med Chem 39: 949-56 (1996)


Article DOI: 10.1021/jm950736k
BindingDB Entry DOI: 10.7270/Q2SN082H
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50049962
PNG
(CHEMBL172844 | [7-(2-Amino-6-oxo-1,6-dihydro-purin...)
Show SMILES Nc1nc2n(CCCCCCCP(O)(O)=O)cnc2c(=O)[nH]1
Show InChI InChI=1S/C12H20N5O4P/c13-12-15-10-9(11(18)16-12)14-8-17(10)6-4-2-1-3-5-7-22(19,20)21/h8H,1-7H2,(H2,19,20,21)(H3,13,15,16,18)
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530n/an/an/an/an/an/an/an/a



Burroughs Wellcome Co.

Curated by ChEMBL


Assay Description
In vitro inhibition of purine nucleoside phosphorylase isolated from human erythrocytes.


J Med Chem 39: 949-56 (1996)


Article DOI: 10.1021/jm950736k
BindingDB Entry DOI: 10.7270/Q2SN082H
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50049958
PNG
(CHEMBL172306 | [5-(5-Amino-7-oxo-6,7-dihydro-[1,2,...)
Show SMILES Nc1nc2nn(COCCCCCP(O)(O)=O)nc2c(=O)[nH]1
Show InChI InChI=1S/C10H17N6O5P/c11-10-12-8-7(9(17)13-10)14-16(15-8)6-21-4-2-1-3-5-22(18,19)20/h1-6H2,(H2,18,19,20)(H3,11,12,13,15,17)
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550n/an/an/an/an/an/an/an/a



Burroughs Wellcome Co.

Curated by ChEMBL


Assay Description
In vitro inhibition of purine nucleoside phosphorylase isolated from human erythrocytes.


J Med Chem 39: 949-56 (1996)


Article DOI: 10.1021/jm950736k
BindingDB Entry DOI: 10.7270/Q2SN082H
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50049970
PNG
(CHEMBL176480 | TCMDC-137339 | [7-(6-Amino-4-oxo-4,...)
Show SMILES Nc1nc2n(CCCCCCCP(O)(O)=O)ncc2c(=O)[nH]1
Show InChI InChI=1S/C12H20N5O4P/c13-12-15-10-9(11(18)16-12)8-14-17(10)6-4-2-1-3-5-7-22(19,20)21/h8H,1-7H2,(H2,19,20,21)(H3,13,15,16,18)
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580n/an/an/an/an/an/an/an/a



Burroughs Wellcome Co.

Curated by ChEMBL


Assay Description
In vitro inhibition of purine nucleoside phosphorylase isolated from human erythrocytes.


J Med Chem 39: 949-56 (1996)


Article DOI: 10.1021/jm950736k
BindingDB Entry DOI: 10.7270/Q2SN082H
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50042366
PNG
(CHEMBL116580 | [3-(2-Amino-6-oxo-1,6-dihydro-purin...)
Show SMILES Nc1nc2n(Cc3cccc(OCP(O)(O)=O)c3)cnc2c(=O)[nH]1
Show InChI InChI=1S/C13H14N5O5P/c14-13-16-11-10(12(19)17-13)15-6-18(11)5-8-2-1-3-9(4-8)23-7-24(20,21)22/h1-4,6H,5,7H2,(H2,20,21,22)(H3,14,16,17,19)
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600n/an/an/an/an/an/an/an/a



Burroughs Wellcome Co.

Curated by ChEMBL


Assay Description
Inhibition of purine nucleoside phosphorylase of human erythrocytes in xanthine oxidase-coupled assay


J Med Chem 36: 3455-63 (1993)


Article DOI: 10.1021/jm00074a029
BindingDB Entry DOI: 10.7270/Q2PR7V1V
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50049964
PNG
(CHEMBL173083 | [6-(6-Amino-4-oxo-4,5-dihydro-pyraz...)
Show SMILES Nc1nc2n(COCCCCCCP(O)(O)=O)ncc2c(=O)[nH]1
Show InChI InChI=1S/C12H20N5O5P/c13-12-15-10-9(11(18)16-12)7-14-17(10)8-22-5-3-1-2-4-6-23(19,20)21/h7H,1-6,8H2,(H2,19,20,21)(H3,13,15,16,18)
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630n/an/an/an/an/an/an/an/a



Burroughs Wellcome Co.

Curated by ChEMBL


Assay Description
In vitro inhibition of purine nucleoside phosphorylase isolated from human erythrocytes.


J Med Chem 39: 949-56 (1996)


Article DOI: 10.1021/jm950736k
BindingDB Entry DOI: 10.7270/Q2SN082H
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50033660
PNG
(CHEMBL269745 | {[5-(2-Amino-6-oxo-1,6-dihydro-puri...)
Show SMILES Nc1nc2n(CCCCCP(O)(=O)CP(O)(O)=O)cnc2c(=O)[nH]1
Show InChI InChI=1S/C11H19N5O6P2/c12-11-14-9-8(10(17)15-11)13-6-16(9)4-2-1-3-5-23(18,19)7-24(20,21)22/h6H,1-5,7H2,(H,18,19)(H2,20,21,22)(H3,12,14,15,17)
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900n/an/an/an/an/an/an/an/a



Burroughs Wellcome Co.

Curated by ChEMBL


Assay Description
Inhibition of human erythrocyte purine nucleoside phosphorylase (PNPase) in the presence of ethylenediaminetetraacetic acid (Na2 EDTA)


J Med Chem 38: 1005-14 (1995)


Article DOI: 10.1021/jm00006a020
BindingDB Entry DOI: 10.7270/Q2FF3RDR
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50042361
PNG
(CHEMBL324839 | {3-[2-(2-Amino-6-oxo-1,6-dihydro-pu...)
Show SMILES Nc1nc2n(Cc3ccccc3OCCCP(O)(O)=O)cnc2c(=O)[nH]1
Show InChI InChI=1S/C15H18N5O5P/c16-15-18-13-12(14(21)19-15)17-9-20(13)8-10-4-1-2-5-11(10)25-6-3-7-26(22,23)24/h1-2,4-5,9H,3,6-8H2,(H2,22,23,24)(H3,16,18,19,21)
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1.00E+3n/an/an/an/an/an/an/an/a



Burroughs Wellcome Co.

Curated by ChEMBL


Assay Description
Inhibition of purine nucleoside phosphorylase of human erythrocytes in xanthine oxidase-coupled assay


J Med Chem 36: 3455-63 (1993)


Article DOI: 10.1021/jm00074a029
BindingDB Entry DOI: 10.7270/Q2PR7V1V
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50033661
PNG
(CHEMBL7247 | {[7-(2-Amino-6-oxo-1,6-dihydro-purin-...)
Show SMILES Nc1nc2n(CCCCCCCP(O)(=O)CP(O)(O)=O)cnc2c(=O)[nH]1
Show InChI InChI=1S/C13H23N5O6P2/c14-13-16-11-10(12(19)17-13)15-8-18(11)6-4-2-1-3-5-7-25(20,21)9-26(22,23)24/h8H,1-7,9H2,(H,20,21)(H2,22,23,24)(H3,14,16,17,19)
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PubMed
1.10E+3n/an/an/an/an/an/an/an/a



Burroughs Wellcome Co.

Curated by ChEMBL


Assay Description
Inhibition of human erythrocyte purine nucleoside phosphorylase (PNPase) in the presence of ethylenediaminetetraacetic acid (Na2 EDTA)


J Med Chem 38: 1005-14 (1995)


Article DOI: 10.1021/jm00006a020
BindingDB Entry DOI: 10.7270/Q2FF3RDR
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50033665
PNG
(CHEMBL268378 | {[5-(2-Amino-6-oxo-1,6-dihydro-puri...)
Show SMILES CCOP(O)(=O)CP(O)(=O)CCCCCn1cnc2c1nc(N)[nH]c2=O
Show InChI InChI=1S/C13H23N5O6P2/c1-2-24-26(22,23)9-25(20,21)7-5-3-4-6-18-8-15-10-11(18)16-13(14)17-12(10)19/h8H,2-7,9H2,1H3,(H,20,21)(H,22,23)(H3,14,16,17,19)
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PubMed
1.10E+3n/an/an/an/an/an/an/an/a



Burroughs Wellcome Co.

Curated by ChEMBL


Assay Description
Inhibition of human erythrocyte purine nucleoside phosphorylase (PNPase) in the presence of zinc chloride


J Med Chem 38: 1005-14 (1995)


Article DOI: 10.1021/jm00006a020
BindingDB Entry DOI: 10.7270/Q2FF3RDR
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50049956
PNG
(CHEMBL176649 | [8-(6-Amino-4-oxo-4,5-dihydro-pyraz...)
Show SMILES Nc1nc2n(CCCCCCCCP(O)(O)=O)ncc2c(=O)[nH]1
Show InChI InChI=1S/C13H22N5O4P/c14-13-16-11-10(12(19)17-13)9-15-18(11)7-5-3-1-2-4-6-8-23(20,21)22/h9H,1-8H2,(H2,20,21,22)(H3,14,16,17,19)
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PubMed
1.10E+3n/an/an/an/an/an/an/an/a



Burroughs Wellcome Co.

Curated by ChEMBL


Assay Description
In vitro inhibition of purine nucleoside phosphorylase isolated from human erythrocytes.


J Med Chem 39: 949-56 (1996)


Article DOI: 10.1021/jm950736k
BindingDB Entry DOI: 10.7270/Q2SN082H
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50033664
PNG
(CHEMBL7068 | {[4-(2-Amino-6-oxo-1,6-dihydro-purin-...)
Show SMILES Nc1nc2n(CCCCP(O)(=O)CP(O)(O)=O)cnc2c(=O)[nH]1
Show InChI InChI=1S/C10H17N5O6P2/c11-10-13-8-7(9(16)14-10)12-5-15(8)3-1-2-4-22(17,18)6-23(19,20)21/h5H,1-4,6H2,(H,17,18)(H2,19,20,21)(H3,11,13,14,16)
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PubMed
1.40E+3n/an/an/an/an/an/an/an/a



Burroughs Wellcome Co.

Curated by ChEMBL


Assay Description
Inhibition of human erythrocyte purine nucleoside phosphorylase (PNPase) in the presence of ethylenediaminetetraacetic acid (Na2 EDTA)


J Med Chem 38: 1005-14 (1995)


Article DOI: 10.1021/jm00006a020
BindingDB Entry DOI: 10.7270/Q2FF3RDR
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50033662
PNG
(CHEMBL7194 | {Hydroxy-[5-(2-hydroxy-6-oxo-1,6-dihy...)
Show SMILES OP(O)(=O)CP(O)(=O)CCCCCn1cnc2c1[nH]c(=O)[nH]c2=O
Show InChI InChI=1S/C11H18N4O7P2/c16-10-8-9(13-11(17)14-10)15(6-12-8)4-2-1-3-5-23(18,19)7-24(20,21)22/h6H,1-5,7H2,(H,18,19)(H2,20,21,22)(H2,13,14,16,17)
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PubMed
1.40E+3n/an/an/an/an/an/an/an/a



Burroughs Wellcome Co.

Curated by ChEMBL


Assay Description
Inhibition of human erythrocyte purine nucleoside phosphorylase (PNPase) in the presence of zinc chloride


J Med Chem 38: 1005-14 (1995)


Article DOI: 10.1021/jm00006a020
BindingDB Entry DOI: 10.7270/Q2FF3RDR
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50049965
PNG
(CHEMBL176447 | [10-(2-Amino-6-oxo-1,6-dihydro-puri...)
Show SMILES Nc1nc2n(CCCCCCCCCCP(O)(O)=O)cnc2c(=O)[nH]1
Show InChI InChI=1S/C15H26N5O4P/c16-15-18-13-12(14(21)19-15)17-11-20(13)9-7-5-3-1-2-4-6-8-10-25(22,23)24/h11H,1-10H2,(H2,22,23,24)(H3,16,18,19,21)
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PubMed
1.60E+3n/an/an/an/an/an/an/an/a



Burroughs Wellcome Co.

Curated by ChEMBL


Assay Description
In vitro inhibition of purine nucleoside phosphorylase isolated from human erythrocytes.


J Med Chem 39: 949-56 (1996)


Article DOI: 10.1021/jm950736k
BindingDB Entry DOI: 10.7270/Q2SN082H
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50042360
PNG
(CHEMBL117588 | [4-(2-Amino-6-oxo-1,6-dihydro-purin...)
Show SMILES Nc1nc2n(Cc3ccc(COCP(O)(O)=O)cc3)cnc2c(=O)[nH]1
Show InChI InChI=1S/C14H16N5O5P/c15-14-17-12-11(13(20)18-14)16-7-19(12)5-9-1-3-10(4-2-9)6-24-8-25(21,22)23/h1-4,7H,5-6,8H2,(H2,21,22,23)(H3,15,17,18,20)
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PubMed
3.50E+3n/an/an/an/an/an/an/an/a



Burroughs Wellcome Co.

Curated by ChEMBL


Assay Description
Inhibition of purine nucleoside phosphorylase of human erythrocytes in xanthine oxidase-coupled assay


J Med Chem 36: 3455-63 (1993)


Article DOI: 10.1021/jm00074a029
BindingDB Entry DOI: 10.7270/Q2PR7V1V
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50042368
PNG
(CHEMBL446671 | [4-(2-Amino-6-oxo-1,6-dihydro-purin...)
Show SMILES Nc1nc2n(Cc3ccc(cc3)P(O)(O)=O)cnc2c(=O)[nH]1
Show InChI InChI=1S/C12H12N5O4P/c13-12-15-10-9(11(18)16-12)14-6-17(10)5-7-1-3-8(4-2-7)22(19,20)21/h1-4,6H,5H2,(H2,19,20,21)(H3,13,15,16,18)
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PubMed
7.00E+3n/an/an/an/an/an/an/an/a



Burroughs Wellcome Co.

Curated by ChEMBL


Assay Description
Inhibition of purine nucleoside phosphorylase of human erythrocytes in xanthine oxidase-coupled assay


J Med Chem 36: 3455-63 (1993)


Article DOI: 10.1021/jm00074a029
BindingDB Entry DOI: 10.7270/Q2PR7V1V
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50049973
PNG
(CHEMBL175305 | [4-(5-Amino-7-oxo-6,7-dihydro-[1,2,...)
Show SMILES Nc1nc2n(CCCCP(O)(O)=O)nnc2c(=O)[nH]1
Show InChI InChI=1S/C8H13N6O4P/c9-8-10-6-5(7(15)11-8)12-13-14(6)3-1-2-4-19(16,17)18/h1-4H2,(H2,16,17,18)(H3,9,10,11,15)
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PubMed
7.30E+3n/an/an/an/an/an/an/an/a



Burroughs Wellcome Co.

Curated by ChEMBL


Assay Description
In vitro inhibition of purine nucleoside phosphorylase isolated from human erythrocytes.


J Med Chem 39: 949-56 (1996)


Article DOI: 10.1021/jm950736k
BindingDB Entry DOI: 10.7270/Q2SN082H
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50033665
PNG
(CHEMBL268378 | {[5-(2-Amino-6-oxo-1,6-dihydro-puri...)
Show SMILES CCOP(O)(=O)CP(O)(=O)CCCCCn1cnc2c1nc(N)[nH]c2=O
Show InChI InChI=1S/C13H23N5O6P2/c1-2-24-26(22,23)9-25(20,21)7-5-3-4-6-18-8-15-10-11(18)16-13(14)17-12(10)19/h8H,2-7,9H2,1H3,(H,20,21)(H,22,23)(H3,14,16,17,19)
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PubMed
1.40E+4n/an/an/an/an/an/an/an/a



Burroughs Wellcome Co.

Curated by ChEMBL


Assay Description
Inhibition of human erythrocyte purine nucleoside phosphorylase (PNPase) in the presence of ethylenediaminetetraacetic acid (Na2 EDTA)


J Med Chem 38: 1005-14 (1995)


Article DOI: 10.1021/jm00006a020
BindingDB Entry DOI: 10.7270/Q2FF3RDR
More data for this
Ligand-Target Pair
Purine nucleoside phosphorylase


(Homo sapiens (human))
BDBM50042371
PNG
(CHEMBL327003 | [4-(2-Amino-6-oxo-1,6-dihydro-purin...)
Show SMILES Nc1nc2n(Cc3ccc(OCP(O)(O)=O)cc3)cnc2c(=O)[nH]1
Show InChI InChI=1S/C13H14N5O5P/c14-13-16-11-10(12(19)17-13)15-6-18(11)5-8-1-3-9(4-2-8)23-7-24(20,21)22/h1-4,6H,5,7H2,(H2,20,21,22)(H3,14,16,17,19)
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2.70E+5n/an/an/an/an/an/an/an/a



Burroughs Wellcome Co.

Curated by ChEMBL


Assay Description
Inhibition of purine nucleoside phosphorylase of human erythrocytes in xanthine oxidase-coupled assay


J Med Chem 36: 3455-63 (1993)


Article DOI: 10.1021/jm00074a029
BindingDB Entry DOI: 10.7270/Q2PR7V1V
More data for this
Ligand-Target Pair
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