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Compile Data Set for Download or QSAR

Found 94 hits from CGI Pharmaceuticals, Inc.   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50312155
PNG
(1-(2-methoxy-5-(trifluoromethyl)phenyl)-3-(3-(8-(p...)
Show SMILES COc1ccc(cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1)C(F)(F)F
Show InChI InChI=1S/C27H22F3N7O2/c1-39-23-6-5-19(27(28,29)30)14-21(23)36-26(38)34-20-4-2-3-18(13-20)22-16-37-12-11-32-25(37)24(35-22)33-15-17-7-9-31-10-8-17/h2-14,16H,15H2,1H3,(H,33,35)(H2,34,36,38)
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n/an/a 7n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 after 1 hr


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
BindingDB Entry DOI: 10.7270/Q2DR2VM3
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50312157
PNG
(1-(5-bromo-2-methoxyphenyl)-3-(3-(8-(pyridin-4-ylm...)
Show SMILES COc1ccc(Br)cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1
Show InChI InChI=1S/C26H22BrN7O2/c1-36-23-6-5-19(27)14-21(23)33-26(35)31-20-4-2-3-18(13-20)22-16-34-12-11-29-25(34)24(32-22)30-15-17-7-9-28-10-8-17/h2-14,16H,15H2,1H3,(H,30,32)(H2,31,33,35)
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n/an/a 10n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
BindingDB Entry DOI: 10.7270/Q2DR2VM3
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50312156
PNG
(1-(2-fluoro-5-(trifluoromethyl)phenyl)-3-(3-(8-(py...)
Show SMILES Fc1ccc(cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1)C(F)(F)F
Show InChI InChI=1S/C26H19F4N7O/c27-20-5-4-18(26(28,29)30)13-21(20)36-25(38)34-19-3-1-2-17(12-19)22-15-37-11-10-32-24(37)23(35-22)33-14-16-6-8-31-9-7-16/h1-13,15H,14H2,(H,33,35)(H2,34,36,38)
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n/an/a 13n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
BindingDB Entry DOI: 10.7270/Q2DR2VM3
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312157
PNG
(1-(5-bromo-2-methoxyphenyl)-3-(3-(8-(pyridin-4-ylm...)
Show SMILES COc1ccc(Br)cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1
Show InChI InChI=1S/C26H22BrN7O2/c1-36-23-6-5-19(27)14-21(23)33-26(35)31-20-4-2-3-18(13-20)22-16-34-12-11-29-25(34)24(32-22)30-15-17-7-9-28-10-8-17/h2-14,16H,15H2,1H3,(H,30,32)(H2,31,33,35)
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n/an/a 26n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
BindingDB Entry DOI: 10.7270/Q2DR2VM3
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50312155
PNG
(1-(2-methoxy-5-(trifluoromethyl)phenyl)-3-(3-(8-(p...)
Show SMILES COc1ccc(cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1)C(F)(F)F
Show InChI InChI=1S/C27H22F3N7O2/c1-39-23-6-5-19(27(28,29)30)14-21(23)36-26(38)34-20-4-2-3-18(13-20)22-16-37-12-11-32-25(37)24(35-22)33-15-17-7-9-31-10-8-17/h2-14,16H,15H2,1H3,(H,33,35)(H2,34,36,38)
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n/an/a 33n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Tie2 after 1 hr


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
BindingDB Entry DOI: 10.7270/Q2DR2VM3
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50312153
PNG
(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1
Show InChI InChI=1S/C26H20F3N7O/c27-26(28,29)19-4-2-6-21(14-19)34-25(37)33-20-5-1-3-18(13-20)22-16-36-12-11-31-24(36)23(35-22)32-15-17-7-9-30-10-8-17/h1-14,16H,15H2,(H,32,35)(H2,33,34,37)
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n/an/a 33n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
BindingDB Entry DOI: 10.7270/Q2DR2VM3
More data for this
Ligand-Target Pair
Ephrin receptor


(Homo sapiens)
BDBM50312153
PNG
(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1
Show InChI InChI=1S/C26H20F3N7O/c27-26(28,29)19-4-2-6-21(14-19)34-25(37)33-20-5-1-3-18(13-20)22-16-36-12-11-31-24(36)23(35-22)32-15-17-7-9-30-10-8-17/h1-14,16H,15H2,(H,32,35)(H2,33,34,37)
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n/an/a 35n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EPHA2 after 1 hr


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
BindingDB Entry DOI: 10.7270/Q2DR2VM3
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50312156
PNG
(1-(2-fluoro-5-(trifluoromethyl)phenyl)-3-(3-(8-(py...)
Show SMILES Fc1ccc(cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1)C(F)(F)F
Show InChI InChI=1S/C26H19F4N7O/c27-20-5-4-18(26(28,29)30)13-21(20)36-25(38)34-19-3-1-2-17(12-19)22-15-37-11-10-32-24(37)23(35-22)33-14-16-6-8-31-9-7-16/h1-13,15H,14H2,(H,33,35)(H2,34,36,38)
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n/an/a 37n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Tie2 after 1 hr


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
BindingDB Entry DOI: 10.7270/Q2DR2VM3
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312184
PNG
(1-(2-hydroxy-5-(trifluoromethyl)phenyl)-3-(3-(8-(p...)
Show SMILES Oc1ccc(cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1)C(F)(F)F
Show InChI InChI=1S/C26H20F3N7O2/c27-26(28,29)18-4-5-22(37)20(13-18)35-25(38)33-19-3-1-2-17(12-19)21-15-36-11-10-31-24(36)23(34-21)32-14-16-6-8-30-9-7-16/h1-13,15,37H,14H2,(H,32,34)(H2,33,35,38)
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n/an/a 37n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
BindingDB Entry DOI: 10.7270/Q2DR2VM3
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312155
PNG
(1-(2-methoxy-5-(trifluoromethyl)phenyl)-3-(3-(8-(p...)
Show SMILES COc1ccc(cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1)C(F)(F)F
Show InChI InChI=1S/C27H22F3N7O2/c1-39-23-6-5-19(27(28,29)30)14-21(23)36-26(38)34-20-4-2-3-18(13-20)22-16-37-12-11-32-25(37)24(35-22)33-15-17-7-9-31-10-8-17/h2-14,16H,15H2,1H3,(H,33,35)(H2,34,36,38)
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n/an/a 37n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 after 1 hr


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
BindingDB Entry DOI: 10.7270/Q2DR2VM3
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312156
PNG
(1-(2-fluoro-5-(trifluoromethyl)phenyl)-3-(3-(8-(py...)
Show SMILES Fc1ccc(cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1)C(F)(F)F
Show InChI InChI=1S/C26H19F4N7O/c27-20-5-4-18(26(28,29)30)13-21(20)36-25(38)34-19-3-1-2-17(12-19)22-15-37-11-10-32-24(37)23(35-22)33-14-16-6-8-31-9-7-16/h1-13,15H,14H2,(H,33,35)(H2,34,36,38)
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n/an/a 49n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 after 1 hr


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
BindingDB Entry DOI: 10.7270/Q2DR2VM3
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50312155
PNG
(1-(2-methoxy-5-(trifluoromethyl)phenyl)-3-(3-(8-(p...)
Show SMILES COc1ccc(cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1)C(F)(F)F
Show InChI InChI=1S/C27H22F3N7O2/c1-39-23-6-5-19(27(28,29)30)14-21(23)36-26(38)34-20-4-2-3-18(13-20)22-16-37-12-11-32-25(37)24(35-22)33-15-17-7-9-31-10-8-17/h2-14,16H,15H2,1H3,(H,33,35)(H2,34,36,38)
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n/an/a 50n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Tie2 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
BindingDB Entry DOI: 10.7270/Q2DR2VM3
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312155
PNG
(1-(2-methoxy-5-(trifluoromethyl)phenyl)-3-(3-(8-(p...)
Show SMILES COc1ccc(cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1)C(F)(F)F
Show InChI InChI=1S/C27H22F3N7O2/c1-39-23-6-5-19(27(28,29)30)14-21(23)36-26(38)34-20-4-2-3-18(13-20)22-16-37-12-11-32-25(37)24(35-22)33-15-17-7-9-31-10-8-17/h2-14,16H,15H2,1H3,(H,33,35)(H2,34,36,38)
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n/an/a 50n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
BindingDB Entry DOI: 10.7270/Q2DR2VM3
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312157
PNG
(1-(5-bromo-2-methoxyphenyl)-3-(3-(8-(pyridin-4-ylm...)
Show SMILES COc1ccc(Br)cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1
Show InChI InChI=1S/C26H22BrN7O2/c1-36-23-6-5-19(27)14-21(23)33-26(35)31-20-4-2-3-18(13-20)22-16-34-12-11-29-25(34)24(32-22)30-15-17-7-9-28-10-8-17/h2-14,16H,15H2,1H3,(H,30,32)(H2,31,33,35)
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n/an/a 50n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
BindingDB Entry DOI: 10.7270/Q2DR2VM3
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312153
PNG
(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1
Show InChI InChI=1S/C26H20F3N7O/c27-26(28,29)19-4-2-6-21(14-19)34-25(37)33-20-5-1-3-18(13-20)22-16-36-12-11-31-24(36)23(35-22)32-15-17-7-9-30-10-8-17/h1-14,16H,15H2,(H,32,35)(H2,33,34,37)
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n/an/a 62n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
BindingDB Entry DOI: 10.7270/Q2DR2VM3
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312187
PNG
(1-(2-chloro-5-(trifluoromethyl)phenyl)-3-(3-(8-(py...)
Show SMILES FC(F)(F)c1ccc(Cl)c(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1
Show InChI InChI=1S/C26H19ClF3N7O/c27-20-5-4-18(26(28,29)30)13-21(20)36-25(38)34-19-3-1-2-17(12-19)22-15-37-11-10-32-24(37)23(35-22)33-14-16-6-8-31-9-7-16/h1-13,15H,14H2,(H,33,35)(H2,34,36,38)
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n/an/a 66n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
BindingDB Entry DOI: 10.7270/Q2DR2VM3
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50312153
PNG
(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1
Show InChI InChI=1S/C26H20F3N7O/c27-26(28,29)19-4-2-6-21(14-19)34-25(37)33-20-5-1-3-18(13-20)22-16-36-12-11-31-24(36)23(35-22)32-15-17-7-9-30-10-8-17/h1-14,16H,15H2,(H,32,35)(H2,33,34,37)
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n/an/a 67n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Tie2 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
BindingDB Entry DOI: 10.7270/Q2DR2VM3
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312200
PNG
(1-(3-(8-(methyl(pyridin-4-ylmethyl)amino)imidazo[1...)
Show SMILES CN(Cc1ccncc1)c1nc(cn2ccnc12)-c1cccc(NC(=O)Nc2cccc(c2)C(F)(F)F)c1
Show InChI InChI=1S/C27H22F3N7O/c1-36(16-18-8-10-31-11-9-18)25-24-32-12-13-37(24)17-23(35-25)19-4-2-6-21(14-19)33-26(38)34-22-7-3-5-20(15-22)27(28,29)30/h2-15,17H,16H2,1H3,(H2,33,34,38)
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n/an/a 69n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
BindingDB Entry DOI: 10.7270/Q2DR2VM3
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM50312153
PNG
(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1
Show InChI InChI=1S/C26H20F3N7O/c27-26(28,29)19-4-2-6-21(14-19)34-25(37)33-20-5-1-3-18(13-20)22-16-36-12-11-31-24(36)23(35-22)32-15-17-7-9-30-10-8-17/h1-14,16H,15H2,(H,32,35)(H2,33,34,37)
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n/an/a 71n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR3 after 1 hr


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
BindingDB Entry DOI: 10.7270/Q2DR2VM3
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50312157
PNG
(1-(5-bromo-2-methoxyphenyl)-3-(3-(8-(pyridin-4-ylm...)
Show SMILES COc1ccc(Br)cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1
Show InChI InChI=1S/C26H22BrN7O2/c1-36-23-6-5-19(27)14-21(23)33-26(35)31-20-4-2-3-18(13-20)22-16-34-12-11-29-25(34)24(32-22)30-15-17-7-9-28-10-8-17/h2-14,16H,15H2,1H3,(H,30,32)(H2,31,33,35)
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n/an/a 75n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Tie2 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
BindingDB Entry DOI: 10.7270/Q2DR2VM3
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312178
PNG
(1-(5-chloro-2-methoxyphenyl)-3-(3-(8-(pyridin-4-yl...)
Show SMILES COc1ccc(Cl)cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1
Show InChI InChI=1S/C26H22ClN7O2/c1-36-23-6-5-19(27)14-21(23)33-26(35)31-20-4-2-3-18(13-20)22-16-34-12-11-29-25(34)24(32-22)30-15-17-7-9-28-10-8-17/h2-14,16H,15H2,1H3,(H,30,32)(H2,31,33,35)
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n/an/a 77n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
BindingDB Entry DOI: 10.7270/Q2DR2VM3
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312175
PNG
(1-(2-methoxy-5-methylphenyl)-3-(3-(8-(pyridin-4-yl...)
Show SMILES COc1ccc(C)cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1
Show InChI InChI=1S/C27H25N7O2/c1-18-6-7-24(36-2)22(14-18)33-27(35)31-21-5-3-4-20(15-21)23-17-34-13-12-29-26(34)25(32-23)30-16-19-8-10-28-11-9-19/h3-15,17H,16H2,1-2H3,(H,30,32)(H2,31,33,35)
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n/an/a 78n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
BindingDB Entry DOI: 10.7270/Q2DR2VM3
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50312156
PNG
(1-(2-fluoro-5-(trifluoromethyl)phenyl)-3-(3-(8-(py...)
Show SMILES Fc1ccc(cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1)C(F)(F)F
Show InChI InChI=1S/C26H19F4N7O/c27-20-5-4-18(26(28,29)30)13-21(20)36-25(38)34-19-3-1-2-17(12-19)22-15-37-11-10-32-24(37)23(35-22)33-14-16-6-8-31-9-7-16/h1-13,15H,14H2,(H,33,35)(H2,34,36,38)
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n/an/a 100n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Tie2 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
BindingDB Entry DOI: 10.7270/Q2DR2VM3
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50312157
PNG
(1-(5-bromo-2-methoxyphenyl)-3-(3-(8-(pyridin-4-ylm...)
Show SMILES COc1ccc(Br)cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1
Show InChI InChI=1S/C26H22BrN7O2/c1-36-23-6-5-19(27)14-21(23)33-26(35)31-20-4-2-3-18(13-20)22-16-34-12-11-29-25(34)24(32-22)30-15-17-7-9-28-10-8-17/h2-14,16H,15H2,1H3,(H,30,32)(H2,31,33,35)
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n/an/a 100n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
BindingDB Entry DOI: 10.7270/Q2DR2VM3
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50312156
PNG
(1-(2-fluoro-5-(trifluoromethyl)phenyl)-3-(3-(8-(py...)
Show SMILES Fc1ccc(cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1)C(F)(F)F
Show InChI InChI=1S/C26H19F4N7O/c27-20-5-4-18(26(28,29)30)13-21(20)36-25(38)34-19-3-1-2-17(12-19)22-15-37-11-10-32-24(37)23(35-22)33-14-16-6-8-31-9-7-16/h1-13,15H,14H2,(H,33,35)(H2,34,36,38)
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n/an/a 100n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
BindingDB Entry DOI: 10.7270/Q2DR2VM3
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50312155
PNG
(1-(2-methoxy-5-(trifluoromethyl)phenyl)-3-(3-(8-(p...)
Show SMILES COc1ccc(cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1)C(F)(F)F
Show InChI InChI=1S/C27H22F3N7O2/c1-39-23-6-5-19(27(28,29)30)14-21(23)36-26(38)34-20-4-2-3-18(13-20)22-16-37-12-11-32-25(37)24(35-22)33-15-17-7-9-31-10-8-17/h2-14,16H,15H2,1H3,(H,33,35)(H2,34,36,38)
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n/an/a 100n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
BindingDB Entry DOI: 10.7270/Q2DR2VM3
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312185
PNG
(1-(2,5-dichlorophenyl)-3-(3-(8-(pyridin-4-ylmethyl...)
Show SMILES Clc1ccc(Cl)c(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1
Show InChI InChI=1S/C25H19Cl2N7O/c26-18-4-5-20(27)21(13-18)33-25(35)31-19-3-1-2-17(12-19)22-15-34-11-10-29-24(34)23(32-22)30-14-16-6-8-28-9-7-16/h1-13,15H,14H2,(H,30,32)(H2,31,33,35)
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n/an/a 101n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
BindingDB Entry DOI: 10.7270/Q2DR2VM3
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312201
PNG
(1-(3-(8-(pyridin-4-ylmethoxy)imidazo[1,2-a]pyrazin...)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(OCc3ccncc3)n2)c1
Show InChI InChI=1S/C26H19F3N6O2/c27-26(28,29)19-4-2-6-21(14-19)33-25(36)32-20-5-1-3-18(13-20)22-15-35-12-11-31-23(35)24(34-22)37-16-17-7-9-30-10-8-17/h1-15H,16H2,(H2,32,33,36)
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n/an/a 105n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
BindingDB Entry DOI: 10.7270/Q2DR2VM3
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312174
PNG
(1-(5-cyano-2-methoxyphenyl)-3-(3-(8-(pyridin-4-ylm...)
Show SMILES COc1ccc(cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1)C#N
Show InChI InChI=1S/C27H22N8O2/c1-37-24-6-5-19(15-28)13-22(24)34-27(36)32-21-4-2-3-20(14-21)23-17-35-12-11-30-26(35)25(33-23)31-16-18-7-9-29-10-8-18/h2-14,17H,16H2,1H3,(H,31,33)(H2,32,34,36)
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n/an/a 125n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
BindingDB Entry DOI: 10.7270/Q2DR2VM3
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312177
PNG
(1-(5-chloro-2-phenoxyphenyl)-3-(3-(8-(pyridin-4-yl...)
Show SMILES Clc1ccc(Oc2ccccc2)c(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1
Show InChI InChI=1S/C31H24ClN7O2/c32-23-9-10-28(41-25-7-2-1-3-8-25)26(18-23)38-31(40)36-24-6-4-5-22(17-24)27-20-39-16-15-34-30(39)29(37-27)35-19-21-11-13-33-14-12-21/h1-18,20H,19H2,(H,35,37)(H2,36,38,40)
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n/an/a 138n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
BindingDB Entry DOI: 10.7270/Q2DR2VM3
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312203
PNG
(1-(3-(8-(2-(pyridin-4-yl)ethylamino)imidazo[1,2-a]...)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCCc3ccncc3)n2)c1
Show InChI InChI=1S/C27H22F3N7O/c28-27(29,30)20-4-2-6-22(16-20)35-26(38)34-21-5-1-3-19(15-21)23-17-37-14-13-33-25(37)24(36-23)32-12-9-18-7-10-31-11-8-18/h1-8,10-11,13-17H,9,12H2,(H,32,36)(H2,34,35,38)
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n/an/a 158n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
BindingDB Entry DOI: 10.7270/Q2DR2VM3
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312176
PNG
(1-(5-chloro-2-methylphenyl)-3-(3-(8-(pyridin-4-ylm...)
Show SMILES Cc1ccc(Cl)cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1
Show InChI InChI=1S/C26H22ClN7O/c1-17-5-6-20(27)14-22(17)33-26(35)31-21-4-2-3-19(13-21)23-16-34-12-11-29-25(34)24(32-23)30-15-18-7-9-28-10-8-18/h2-14,16H,15H2,1H3,(H,30,32)(H2,31,33,35)
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n/an/a 160n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
BindingDB Entry DOI: 10.7270/Q2DR2VM3
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312197
PNG
(1-(3-chlorophenyl)-3-(3-(8-(pyridin-4-ylmethylamin...)
Show SMILES Clc1cccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1
Show InChI InChI=1S/C25H20ClN7O/c26-19-4-2-6-21(14-19)31-25(34)30-20-5-1-3-18(13-20)22-16-33-12-11-28-24(33)23(32-22)29-15-17-7-9-27-10-8-17/h1-14,16H,15H2,(H,29,32)(H2,30,31,34)
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n/an/a 165n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
BindingDB Entry DOI: 10.7270/Q2DR2VM3
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312169
PNG
(1-(5-bromo-2,4-dimethoxyphenyl)-3-(3-(8-(pyridin-4...)
Show SMILES COc1cc(OC)c(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)cc1Br
Show InChI InChI=1S/C27H24BrN7O3/c1-37-23-14-24(38-2)21(13-20(23)28)34-27(36)32-19-5-3-4-18(12-19)22-16-35-11-10-30-26(35)25(33-22)31-15-17-6-8-29-9-7-17/h3-14,16H,15H2,1-2H3,(H,31,33)(H2,32,34,36)
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n/an/a 206n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
BindingDB Entry DOI: 10.7270/Q2DR2VM3
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312167
PNG
(1-(2,4-diethoxy-5-(trifluoromethyl)phenyl)-3-(3-(8...)
Show SMILES CCOc1cc(OCC)c(cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1)C(F)(F)F
Show InChI InChI=1S/C30H28F3N7O3/c1-3-42-25-16-26(43-4-2)23(15-22(25)30(31,32)33)39-29(41)37-21-7-5-6-20(14-21)24-18-40-13-12-35-28(40)27(38-24)36-17-19-8-10-34-11-9-19/h5-16,18H,3-4,17H2,1-2H3,(H,36,38)(H2,37,39,41)
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n/an/a 211n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
BindingDB Entry DOI: 10.7270/Q2DR2VM3
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312196
PNG
(1-(3-bromophenyl)-3-(3-(8-(pyridin-4-ylmethylamino...)
Show SMILES Brc1cccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1
Show InChI InChI=1S/C25H20BrN7O/c26-19-4-2-6-21(14-19)31-25(34)30-20-5-1-3-18(13-20)22-16-33-12-11-28-24(33)23(32-22)29-15-17-7-9-27-10-8-17/h1-14,16H,15H2,(H,29,32)(H2,30,31,34)
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n/an/a 213n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
BindingDB Entry DOI: 10.7270/Q2DR2VM3
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50312157
PNG
(1-(5-bromo-2-methoxyphenyl)-3-(3-(8-(pyridin-4-ylm...)
Show SMILES COc1ccc(Br)cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1
Show InChI InChI=1S/C26H22BrN7O2/c1-36-23-6-5-19(27)14-21(23)33-26(35)31-20-4-2-3-18(13-20)22-16-34-12-11-29-25(34)24(32-22)30-15-17-7-9-28-10-8-17/h2-14,16H,15H2,1H3,(H,30,32)(H2,31,33,35)
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n/an/a 250n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Tie2 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
BindingDB Entry DOI: 10.7270/Q2DR2VM3
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312195
PNG
(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Show SMILES Cc1cccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1
Show InChI InChI=1S/C26H23N7O/c1-18-4-2-6-21(14-18)30-26(34)31-22-7-3-5-20(15-22)23-17-33-13-12-28-25(33)24(32-23)29-16-19-8-10-27-11-9-19/h2-15,17H,16H2,1H3,(H,29,32)(H2,30,31,34)
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n/an/a 300n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
BindingDB Entry DOI: 10.7270/Q2DR2VM3
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312156
PNG
(1-(2-fluoro-5-(trifluoromethyl)phenyl)-3-(3-(8-(py...)
Show SMILES Fc1ccc(cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1)C(F)(F)F
Show InChI InChI=1S/C26H19F4N7O/c27-20-5-4-18(26(28,29)30)13-21(20)36-25(38)34-19-3-1-2-17(12-19)22-15-37-11-10-32-24(37)23(35-22)33-14-16-6-8-31-9-7-16/h1-13,15H,14H2,(H,33,35)(H2,34,36,38)
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n/an/a 400n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
BindingDB Entry DOI: 10.7270/Q2DR2VM3
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312170
PNG
(1-(5-chloro-2,4-dimethoxyphenyl)-3-(3-(8-(pyridin-...)
Show SMILES COc1cc(OC)c(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)cc1Cl
Show InChI InChI=1S/C27H24ClN7O3/c1-37-23-14-24(38-2)21(13-20(23)28)34-27(36)32-19-5-3-4-18(12-19)22-16-35-11-10-30-26(35)25(33-22)31-15-17-6-8-29-9-7-17/h3-14,16H,15H2,1-2H3,(H,31,33)(H2,32,34,36)
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n/an/a 402n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
BindingDB Entry DOI: 10.7270/Q2DR2VM3
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312166
PNG
(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Show SMILES Clc1cc(Cl)c(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)cc1Cl
Show InChI InChI=1S/C25H18Cl3N7O/c26-18-11-20(28)21(12-19(18)27)34-25(36)32-17-3-1-2-16(10-17)22-14-35-9-8-30-24(35)23(33-22)31-13-15-4-6-29-7-5-15/h1-12,14H,13H2,(H,31,33)(H2,32,34,36)
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n/an/a 517n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
BindingDB Entry DOI: 10.7270/Q2DR2VM3
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312168
PNG
(1-(2,4-dimethoxy-5-(trifluoromethyl)phenyl)-3-(3-(...)
Show SMILES COc1cc(OC)c(cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1)C(F)(F)F
Show InChI InChI=1S/C28H24F3N7O3/c1-40-23-14-24(41-2)21(13-20(23)28(29,30)31)37-27(39)35-19-5-3-4-18(12-19)22-16-38-11-10-33-26(38)25(36-22)34-15-17-6-8-32-9-7-17/h3-14,16H,15H2,1-2H3,(H,34,36)(H2,35,37,39)
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n/an/a 518n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
BindingDB Entry DOI: 10.7270/Q2DR2VM3
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312165
PNG
(CHEMBL1079795 | N-(3-(8-(pyridin-4-ylmethylamino)i...)
Show SMILES FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1
Show InChI InChI=1S/C26H19F3N6O/c27-26(28,29)20-5-1-4-19(13-20)25(36)33-21-6-2-3-18(14-21)22-16-35-12-11-31-24(35)23(34-22)32-15-17-7-9-30-10-8-17/h1-14,16H,15H2,(H,32,34)(H,33,36)
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n/an/a 744n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
BindingDB Entry DOI: 10.7270/Q2DR2VM3
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50312153
PNG
(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1
Show InChI InChI=1S/C26H20F3N7O/c27-26(28,29)19-4-2-6-21(14-19)34-25(37)33-20-5-1-3-18(13-20)22-16-36-12-11-31-24(36)23(35-22)32-15-17-7-9-30-10-8-17/h1-14,16H,15H2,(H,32,35)(H2,33,34,37)
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n/an/a 747n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1 after 1 hr


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
BindingDB Entry DOI: 10.7270/Q2DR2VM3
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312173
PNG
(1-(4-methyl-3-(trifluoromethyl)phenyl)-3-(3-(8-(py...)
Show SMILES Cc1ccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)cc1C(F)(F)F
Show InChI InChI=1S/C27H22F3N7O/c1-17-5-6-21(14-22(17)27(28,29)30)35-26(38)34-20-4-2-3-19(13-20)23-16-37-12-11-32-25(37)24(36-23)33-15-18-7-9-31-10-8-18/h2-14,16H,15H2,1H3,(H,33,36)(H2,34,35,38)
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n/an/a 810n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
BindingDB Entry DOI: 10.7270/Q2DR2VM3
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312172
PNG
(1-(4-fluoro-3-(trifluoromethyl)phenyl)-3-(3-(8-(py...)
Show SMILES Fc1ccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)cc1C(F)(F)F
Show InChI InChI=1S/C26H19F4N7O/c27-21-5-4-19(13-20(21)26(28,29)30)35-25(38)34-18-3-1-2-17(12-18)22-15-37-11-10-32-24(37)23(36-22)33-14-16-6-8-31-9-7-16/h1-13,15H,14H2,(H,33,36)(H2,34,35,38)
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n/an/a 850n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
BindingDB Entry DOI: 10.7270/Q2DR2VM3
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312186
PNG
(1-(2,5-dimethylphenyl)-3-(3-(8-(pyridin-4-ylmethyl...)
Show SMILES Cc1ccc(C)c(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1
Show InChI InChI=1S/C27H25N7O/c1-18-6-7-19(2)23(14-18)33-27(35)31-22-5-3-4-21(15-22)24-17-34-13-12-29-26(34)25(32-24)30-16-20-8-10-28-11-9-20/h3-15,17H,16H2,1-2H3,(H,30,32)(H2,31,33,35)
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n/an/a 938n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
BindingDB Entry DOI: 10.7270/Q2DR2VM3
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312179
PNG
(1-(2,6-dichlorophenyl)-3-(3-(8-(pyridin-4-ylmethyl...)
Show SMILES Clc1cccc(Cl)c1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1
Show InChI InChI=1S/C25H19Cl2N7O/c26-19-5-2-6-20(27)22(19)33-25(35)31-18-4-1-3-17(13-18)21-15-34-12-11-29-24(34)23(32-21)30-14-16-7-9-28-10-8-16/h1-13,15H,14H2,(H,30,32)(H2,31,33,35)
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n/an/a 1.00E+3n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
BindingDB Entry DOI: 10.7270/Q2DR2VM3
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312193
PNG
(1-(3-(methylthio)phenyl)-3-(3-(8-(pyridin-4-ylmeth...)
Show SMILES CSc1cccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1
Show InChI InChI=1S/C26H23N7OS/c1-35-22-7-3-6-21(15-22)31-26(34)30-20-5-2-4-19(14-20)23-17-33-13-12-28-25(33)24(32-23)29-16-18-8-10-27-11-9-18/h2-15,17H,16H2,1H3,(H,29,32)(H2,30,31,34)
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n/an/a 1.20E+3n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
BindingDB Entry DOI: 10.7270/Q2DR2VM3
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312171
PNG
(1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(3-(8-(py...)
Show SMILES FC(F)(F)c1cc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)ccc1Cl
Show InChI InChI=1S/C26H19ClF3N7O/c27-21-5-4-19(13-20(21)26(28,29)30)35-25(38)34-18-3-1-2-17(12-18)22-15-37-11-10-32-24(37)23(36-22)33-14-16-6-8-31-9-7-16/h1-13,15H,14H2,(H,33,36)(H2,34,35,38)
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n/an/a 1.20E+3n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
BindingDB Entry DOI: 10.7270/Q2DR2VM3
More data for this
Ligand-Target Pair
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