BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 9 hits from CHINOIN, Ltd   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Prolyl endopeptidase


(Rattus norvegicus)
BDBM50274983
PNG
(2-{3-[(2S)-4,4-Difluoro-2-(pyrrolidinocarbonyl)pyr...)
Show SMILES FC1(F)C[C@H](N(C1)C(=O)CCN1C(=O)c2ccccc2C1=O)C(=O)N1CCCC1
Show InChI InChI=1S/C20H21F2N3O4/c21-20(22)11-15(19(29)23-8-3-4-9-23)25(12-20)16(26)7-10-24-17(27)13-5-1-2-6-14(13)18(24)28/h1-2,5-6,15H,3-4,7-12H2/t15-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem
MMDB
PDB
Article
PubMed
n/an/a 0.810n/an/an/an/an/an/a



CHINOIN, Ltd

Curated by ChEMBL


Assay Description
Inhibition of POP in Sprague-Dawley rat brain homogenates


J Med Chem 51: 7514-22 (2009)


Article DOI: 10.1021/jm800944x
BindingDB Entry DOI: 10.7270/Q2NG4QFC
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Prolyl endopeptidase


(Rattus norvegicus)
BDBM50274985
PNG
(1-{3-Oxo-3-[(2S)-2-(pyrrolidinocarbonyl)pyrrolidin...)
Show SMILES O=C(CCn1c2ccccc2nc(-c2ccccc2)c1=O)N1CCC[C@H]1C(=O)N1CCCC1
Show InChI InChI=1S/C26H28N4O3/c31-23(29-17-8-13-22(29)25(32)28-15-6-7-16-28)14-18-30-21-12-5-4-11-20(21)27-24(26(30)33)19-9-2-1-3-10-19/h1-5,9-12,22H,6-8,13-18H2/t22-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

MMDB
PDB
Article
PubMed
n/an/a 0.880n/an/an/an/an/an/a



CHINOIN, Ltd

Curated by ChEMBL


Assay Description
Inhibition of POP in Sprague-Dawley rat brain homogenates


J Med Chem 51: 7514-22 (2009)


Article DOI: 10.1021/jm800944x
BindingDB Entry DOI: 10.7270/Q2NG4QFC
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Prolyl endopeptidase


(Rattus norvegicus)
BDBM50274959
PNG
((S)-2-(3-oxo-3-(2-(pyrrolidine-1-carbonyl)pyrrolid...)
Show SMILES O=C(CCN1C(=O)c2ccccc2C1=O)N1CCC[C@H]1C(=O)N1CCCC1
Show InChI InChI=1S/C20H23N3O4/c24-17(22-12-5-8-16(22)20(27)21-10-3-4-11-21)9-13-23-18(25)14-6-1-2-7-15(14)19(23)26/h1-2,6-7,16H,3-5,8-13H2/t16-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 3n/an/an/an/an/an/a



CHINOIN, Ltd

Curated by ChEMBL


Assay Description
Inhibition of POP in Sprague-Dawley rat brain homogenates


J Med Chem 51: 7514-22 (2009)


Article DOI: 10.1021/jm800944x
BindingDB Entry DOI: 10.7270/Q2NG4QFC
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Rattus norvegicus)
BDBM50240495
PNG
((R)-1-(4-(pyrrolidine-1-carbonyl)thiazolidin-3-yl)...)
Show SMILES CCCCCCCC(=O)N1CSC[C@H]1C(=O)N1CCCC1
Show InChI InChI=1S/C16H28N2O2S/c1-2-3-4-5-6-9-15(19)18-13-21-12-14(18)16(20)17-10-7-8-11-17/h14H,2-13H2,1H3/t14-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 11n/an/an/an/an/an/a



CHINOIN, Ltd

Curated by ChEMBL


Assay Description
Inhibition of POP in Sprague-Dawley rat brain homogenates


J Med Chem 51: 7514-22 (2009)


Article DOI: 10.1021/jm800944x
BindingDB Entry DOI: 10.7270/Q2NG4QFC
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Rattus norvegicus)
BDBM50051539
PNG
((S)-4-phenyl-1-(2-(pyrrolidine-1-carbonyl)pyrrolid...)
Show SMILES O=C(CCCc1ccccc1)N1CCC[C@H]1C(=O)N1CCCC1
Show InChI InChI=1S/C19H26N2O2/c22-18(12-6-10-16-8-2-1-3-9-16)21-15-7-11-17(21)19(23)20-13-4-5-14-20/h1-3,8-9,17H,4-7,10-15H2/t17-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 30n/an/an/an/an/an/a



CHINOIN, Ltd

Curated by ChEMBL


Assay Description
Inhibition of POP in Sprague-Dawley rat brain homogenates


J Med Chem 51: 7514-22 (2009)


Article DOI: 10.1021/jm800944x
BindingDB Entry DOI: 10.7270/Q2NG4QFC
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Rattus norvegicus)
BDBM50274984
PNG
(2-{4-Oxo-4-[(2S)-2-(pyrrolidinocarbonyl)pyrrolidin...)
Show SMILES O=C(CCCN1C(=O)c2ccccc2C1=O)N1CCC[C@H]1C(=O)N1CCCC1
Show InChI InChI=1S/C21H25N3O4/c25-18(23-13-5-9-17(23)21(28)22-11-3-4-12-22)10-6-14-24-19(26)15-7-1-2-8-16(15)20(24)27/h1-2,7-8,17H,3-6,9-14H2/t17-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 40n/an/an/an/an/an/a



CHINOIN, Ltd

Curated by ChEMBL


Assay Description
Inhibition of POP in Sprague-Dawley rat brain homogenates


J Med Chem 51: 7514-22 (2009)


Article DOI: 10.1021/jm800944x
BindingDB Entry DOI: 10.7270/Q2NG4QFC
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Rattus norvegicus)
BDBM50275012
PNG
(3-{4-Oxo-4-[(2S)-2-(pyrrolidinocarbonyl)pyrrolidin...)
Show SMILES O=C(CCCN1C(=O)NC(C1=O)(c1ccccc1)c1ccccc1)N1CCC[C@H]1C(=O)N1CCCC1
Show InChI InChI=1S/C28H32N4O4/c33-24(31-19-9-15-23(31)25(34)30-17-7-8-18-30)16-10-20-32-26(35)28(29-27(32)36,21-11-3-1-4-12-21)22-13-5-2-6-14-22/h1-6,11-14,23H,7-10,15-20H2,(H,29,36)/t23-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

MMDB
PDB
Article
PubMed
n/an/a 41n/an/an/an/an/an/a



CHINOIN, Ltd

Curated by ChEMBL


Assay Description
Inhibition of POP in Sprague-Dawley rat brain homogenates


J Med Chem 51: 7514-22 (2009)


Article DOI: 10.1021/jm800944x
BindingDB Entry DOI: 10.7270/Q2NG4QFC
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Prolyl endopeptidase


(Rattus norvegicus)
BDBM50240498
PNG
((S)-1-(2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl)o...)
Show SMILES CCCCCCCC(=O)N1CCC[C@H]1C(=O)N1CCCC1
Show InChI InChI=1S/C17H30N2O2/c1-2-3-4-5-6-11-16(20)19-14-9-10-15(19)17(21)18-12-7-8-13-18/h15H,2-14H2,1H3/t15-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 48n/an/an/an/an/an/a



CHINOIN, Ltd

Curated by ChEMBL


Assay Description
Inhibition of POP in Sprague-Dawley rat brain homogenates


J Med Chem 51: 7514-22 (2009)


Article DOI: 10.1021/jm800944x
BindingDB Entry DOI: 10.7270/Q2NG4QFC
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Rattus norvegicus)
BDBM50274986
PNG
(1-{4-Oxo-4-[(2S)-2-(pyrrolidinocarbonyl)pyrrolidin...)
Show SMILES O=C(CCCn1c2ccccc2nc(-c2ccccc2)c1=O)N1CCC[C@H]1C(=O)N1CCCC1
Show InChI InChI=1S/C27H30N4O3/c32-24(30-18-8-14-23(30)26(33)29-16-6-7-17-29)15-9-19-31-22-13-5-4-12-21(22)28-25(27(31)34)20-10-2-1-3-11-20/h1-5,10-13,23H,6-9,14-19H2/t23-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 59n/an/an/an/an/an/a



CHINOIN, Ltd

Curated by ChEMBL


Assay Description
Inhibition of POP in Sprague-Dawley rat brain homogenates


J Med Chem 51: 7514-22 (2009)


Article DOI: 10.1021/jm800944x
BindingDB Entry DOI: 10.7270/Q2NG4QFC
More data for this
Ligand-Target Pair