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Compile Data Set for Download or QSAR

Found 125 hits from CNRS-BIOCIS   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
HTR4


(RAT)
BDBM29525
PNG
(3H-GR113808 | CHEMBL518682 | GR 113808 | [3H] GR 1...)
Show SMILES Cn1cc(C(=O)OCC2CCN(CCNS(C)(=O)=O)CC2)c2ccccc12
Show InChI InChI=1S/C19H27N3O4S/c1-21-13-17(16-5-3-4-6-18(16)21)19(23)26-14-15-7-10-22(11-8-15)12-9-20-27(2,24)25/h3-6,13,15,20H,7-12,14H2,1-2H3
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0.150n/an/an/an/an/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 4 receptor in rat striatal membranes by [3H]-GR 113808 displacement.


J Med Chem 40: 1755-61 (1997)


Article DOI: 10.1021/jm960853v
BindingDB Entry DOI: 10.7270/Q2NS0T0C
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM29525
PNG
(3H-GR113808 | CHEMBL518682 | GR 113808 | [3H] GR 1...)
Show SMILES Cn1cc(C(=O)OCC2CCN(CCNS(C)(=O)=O)CC2)c2ccccc12
Show InChI InChI=1S/C19H27N3O4S/c1-21-13-17(16-5-3-4-6-18(16)21)19(23)26-14-15-7-10-22(11-8-15)12-9-20-27(2,24)25/h3-6,13,15,20H,7-12,14H2,1-2H3
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0.150n/an/an/an/an/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 4 receptor was determined in rat striatal membranes using [3H]GR-113808 as radioligand


J Med Chem 40: 608-21 (1997)


Article DOI: 10.1021/jm960320m
BindingDB Entry DOI: 10.7270/Q2T72J36
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM50058173
PNG
(4-Amino-5-chloro-2-methoxy-benzoic acid 2-((3S,5R)...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)OCCN1C[C@@H](C)C[C@@H](C)C1
Show InChI InChI=1S/C17H25ClN2O3/c1-11-6-12(2)10-20(9-11)4-5-23-17(21)13-7-14(18)15(19)8-16(13)22-3/h7-8,11-12H,4-6,9-10,19H2,1-3H3/t11-,12+
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0.260n/an/an/an/an/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 4 receptor in rat striatal membranes by [3H]-GR 113808 displacement.


J Med Chem 40: 1755-61 (1997)


Article DOI: 10.1021/jm960853v
BindingDB Entry DOI: 10.7270/Q2NS0T0C
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM50056392
PNG
(4-Amino-5-chloro-2-methoxy-benzoic acid 2-(3,5-dim...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)OCCN1CC(C)CC(C)C1
Show InChI InChI=1S/C17H25ClN2O3/c1-11-6-12(2)10-20(9-11)4-5-23-17(21)13-7-14(18)15(19)8-16(13)22-3/h7-8,11-12H,4-6,9-10,19H2,1-3H3
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0.260n/an/an/an/an/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 4 receptor was determined in rat striatal membranes using [3H]GR-113808 as radioligand


J Med Chem 40: 608-21 (1997)


Article DOI: 10.1021/jm960320m
BindingDB Entry DOI: 10.7270/Q2T72J36
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM50056418
PNG
(4-Amino-5-chloro-2-methoxy-benzoic acid 2-azepan-1...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)OCCN1CCCCCC1
Show InChI InChI=1S/C16H23ClN2O3/c1-21-15-11-14(18)13(17)10-12(15)16(20)22-9-8-19-6-4-2-3-5-7-19/h10-11H,2-9,18H2,1H3
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0.920n/an/an/an/an/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 4 receptor was determined in rat striatal membranes using [3H]GR-113808 as radioligand


J Med Chem 40: 608-21 (1997)


Article DOI: 10.1021/jm960320m
BindingDB Entry DOI: 10.7270/Q2T72J36
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM50056406
PNG
(4-Amino-5-chloro-2-methoxy-benzoic acid 2-(3-methy...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)OCCN1CCCC(C)C1
Show InChI InChI=1S/C16H23ClN2O3/c1-11-4-3-5-19(10-11)6-7-22-16(20)12-8-13(17)14(18)9-15(12)21-2/h8-9,11H,3-7,10,18H2,1-2H3
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0.930n/an/an/an/an/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 4 receptor was determined in rat striatal membranes using [3H]GR-113808 as radioligand


J Med Chem 40: 608-21 (1997)


Article DOI: 10.1021/jm960320m
BindingDB Entry DOI: 10.7270/Q2T72J36
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM50058170
PNG
((2-Ethoxy-phenyl)-carbamic acid 2-((3R,5S)-3,5-dim...)
Show SMILES CCOc1ccccc1NC(=O)OCCN1C[C@@H](C)C[C@@H](C)C1
Show InChI InChI=1S/C18H28N2O3/c1-4-22-17-8-6-5-7-16(17)19-18(21)23-10-9-20-12-14(2)11-15(3)13-20/h5-8,14-15H,4,9-13H2,1-3H3,(H,19,21)/t14-,15+
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1.05n/an/an/an/an/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 4 receptor in rat striatal membranes by [3H]-GR 113808 displacement.


J Med Chem 40: 1755-61 (1997)


Article DOI: 10.1021/jm960853v
BindingDB Entry DOI: 10.7270/Q2NS0T0C
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM29526
PNG
(2-Piperidinoethyl 4-amino-5-chloro-2-methoxybenzoa...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)OCCN1CCCCC1
Show InChI InChI=1S/C15H21ClN2O3/c1-20-14-10-13(17)12(16)9-11(14)15(19)21-8-7-18-5-3-2-4-6-18/h9-10H,2-8,17H2,1H3
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1.07n/an/an/an/an/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 4 receptor in rat striatal membranes by [3H]-GR 113808 displacement.


J Med Chem 40: 1755-61 (1997)


Article DOI: 10.1021/jm960853v
BindingDB Entry DOI: 10.7270/Q2NS0T0C
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM29526
PNG
(2-Piperidinoethyl 4-amino-5-chloro-2-methoxybenzoa...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)OCCN1CCCCC1
Show InChI InChI=1S/C15H21ClN2O3/c1-20-14-10-13(17)12(16)9-11(14)15(19)21-8-7-18-5-3-2-4-6-18/h9-10H,2-8,17H2,1H3
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1.10n/an/an/an/an/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 4 receptor was determined in rat striatal membranes using [3H]GR-113808 as radioligand


J Med Chem 40: 608-21 (1997)


Article DOI: 10.1021/jm960320m
BindingDB Entry DOI: 10.7270/Q2T72J36
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM50056416
PNG
(4-Amino-5-chloro-2-methoxy-benzoic acid 2-(4-acety...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CC1)NC(C)=O
Show InChI InChI=1S/C17H24ClN3O4/c1-11(22)20-12-3-5-21(6-4-12)7-8-25-17(23)13-9-14(18)15(19)10-16(13)24-2/h9-10,12H,3-8,19H2,1-2H3,(H,20,22)
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1.10n/an/an/an/an/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 4 receptor was determined in rat striatal membranes using [3H]GR-113808 as radioligand


J Med Chem 40: 608-21 (1997)


Article DOI: 10.1021/jm960320m
BindingDB Entry DOI: 10.7270/Q2T72J36
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM50454556
PNG
(CHEMBL2115017)
Show SMILES CCOc1ccccc1NC(=O)OCCN1C[C@H](C)C[C@@H](C)C1
Show InChI InChI=1S/C18H28N2O3/c1-4-22-17-8-6-5-7-16(17)19-18(21)23-10-9-20-12-14(2)11-15(3)13-20/h5-8,14-15H,4,9-13H2,1-3H3,(H,19,21)/t14-,15-/m1/s1
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1.20n/an/an/an/an/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 4 receptor in rat striatal membranes by [3H]-GR 113808 displacement.


J Med Chem 40: 1755-61 (1997)


Article DOI: 10.1021/jm960853v
BindingDB Entry DOI: 10.7270/Q2NS0T0C
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM50056424
PNG
(4-Amino-5-chloro-2-methoxy-benzoic acid 2-(4-hydro...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(O)CC1
Show InChI InChI=1S/C15H21ClN2O4/c1-21-14-9-13(17)12(16)8-11(14)15(20)22-7-6-18-4-2-10(19)3-5-18/h8-10,19H,2-7,17H2,1H3
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1.40n/an/an/an/an/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 4 receptor was determined in rat striatal membranes using [3H]GR-113808 as radioligand


J Med Chem 40: 608-21 (1997)


Article DOI: 10.1021/jm960320m
BindingDB Entry DOI: 10.7270/Q2T72J36
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM50056411
PNG
(4-Amino-5-chloro-2-methoxy-benzoic acid 2-(4-carba...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CC1)C(N)=O
Show InChI InChI=1S/C16H22ClN3O4/c1-23-14-9-13(18)12(17)8-11(14)16(22)24-7-6-20-4-2-10(3-5-20)15(19)21/h8-10H,2-7,18H2,1H3,(H2,19,21)
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1.40n/an/an/an/an/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 4 receptor was determined in rat striatal membranes using [3H]GR-113808 as radioligand


J Med Chem 40: 608-21 (1997)


Article DOI: 10.1021/jm960320m
BindingDB Entry DOI: 10.7270/Q2T72J36
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM50056397
PNG
(4-Amino-5-chloro-2-methoxy-benzoic acid 2-(3,3-dim...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)OCCN1CCCC(C)(C)C1
Show InChI InChI=1S/C17H25ClN2O3/c1-17(2)5-4-6-20(11-17)7-8-23-16(21)12-9-13(18)14(19)10-15(12)22-3/h9-10H,4-8,11,19H2,1-3H3
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1.70n/an/an/an/an/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 4 receptor was determined in rat striatal membranes using [3H]GR-113808 as radioligand


J Med Chem 40: 608-21 (1997)


Article DOI: 10.1021/jm960320m
BindingDB Entry DOI: 10.7270/Q2T72J36
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM50056403
PNG
(4-Amino-5-chloro-2-methoxy-benzoic acid 2-(3-hydro...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)OCCN1CCCC(O)C1
Show InChI InChI=1S/C15H21ClN2O4/c1-21-14-8-13(17)12(16)7-11(14)15(20)22-6-5-18-4-2-3-10(19)9-18/h7-8,10,19H,2-6,9,17H2,1H3
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2n/an/an/an/an/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 4 receptor was determined in rat striatal membranes using [3H]GR-113808 as radioligand


J Med Chem 40: 608-21 (1997)


Article DOI: 10.1021/jm960320m
BindingDB Entry DOI: 10.7270/Q2T72J36
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM50056392
PNG
(4-Amino-5-chloro-2-methoxy-benzoic acid 2-(3,5-dim...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)OCCN1CC(C)CC(C)C1
Show InChI InChI=1S/C17H25ClN2O3/c1-11-6-12(2)10-20(9-11)4-5-23-17(21)13-7-14(18)15(19)8-16(13)22-3/h7-8,11-12H,4-6,9-10,19H2,1-3H3
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2.30n/an/an/an/an/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 4 receptor was determined in rat striatal membranes using [3H]GR-113808 as radioligand


J Med Chem 40: 608-21 (1997)


Article DOI: 10.1021/jm960320m
BindingDB Entry DOI: 10.7270/Q2T72J36
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM50058172
PNG
((4-Amino-5-chloro-2-methoxy-phenyl)-carbamic acid ...)
Show SMILES COc1cc(N)c(Cl)cc1NC(=O)OCCN1CC(C)CC(C)C1
Show InChI InChI=1S/C17H26ClN3O3/c1-11-6-12(2)10-21(9-11)4-5-24-17(22)20-15-7-13(18)14(19)8-16(15)23-3/h7-8,11-12H,4-6,9-10,19H2,1-3H3,(H,20,22)
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2.40n/an/an/an/an/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
Binding affinity (Ki+/-SEM) against 5-hydroxytryptamine 4 receptor from cheng Prusoff equation by using [3H]-GR 113808 in rat striatum


J Med Chem 40: 1755-61 (1997)


Article DOI: 10.1021/jm960853v
BindingDB Entry DOI: 10.7270/Q2NS0T0C
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM50058175
PNG
((2-Ethoxy-phenyl)-carbamic acid 2-piperidin-1-yl-e...)
Show SMILES CCOc1ccccc1NC(=O)OCCN1CCCCC1
Show InChI InChI=1S/C16H24N2O3/c1-2-20-15-9-5-4-8-14(15)17-16(19)21-13-12-18-10-6-3-7-11-18/h4-5,8-9H,2-3,6-7,10-13H2,1H3,(H,17,19)
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2.60n/an/an/an/an/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 4 receptor in rat striatal membranes by [3H]-GR 113808 displacement.


J Med Chem 40: 1755-61 (1997)


Article DOI: 10.1021/jm960853v
BindingDB Entry DOI: 10.7270/Q2NS0T0C
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM50058181
PNG
((2-Methoxy-phenyl)-carbamic acid 2-((3R,5S)-3,5-di...)
Show SMILES COc1ccccc1NC(=O)OCCN1C[C@@H](C)C[C@@H](C)C1
Show InChI InChI=1S/C17H26N2O3/c1-13-10-14(2)12-19(11-13)8-9-22-17(20)18-15-6-4-5-7-16(15)21-3/h4-7,13-14H,8-12H2,1-3H3,(H,18,20)/t13-,14+
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2.60n/an/an/an/an/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 4 receptor in rat striatal membranes by [3H]-GR 113808 displacement.


J Med Chem 40: 1755-61 (1997)


Article DOI: 10.1021/jm960853v
BindingDB Entry DOI: 10.7270/Q2NS0T0C
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM50056405
PNG
(4-Amino-5-chloro-2-methoxy-benzoic acid 2-(4-methy...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(C)CC1
Show InChI InChI=1S/C16H23ClN2O3/c1-11-3-5-19(6-4-11)7-8-22-16(20)12-9-13(17)14(18)10-15(12)21-2/h9-11H,3-8,18H2,1-2H3
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4.10n/an/an/an/an/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 4 receptor was determined in rat striatal membranes using [3H]GR-113808 as radioligand


J Med Chem 40: 608-21 (1997)


Article DOI: 10.1021/jm960320m
BindingDB Entry DOI: 10.7270/Q2T72J36
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM50058174
PNG
((5-Chloro-2-methoxy-phenyl)-carbamic acid 2-piperi...)
Show SMILES COc1ccc(Cl)cc1NC(=O)OCCN1CCCCC1
Show InChI InChI=1S/C15H21ClN2O3/c1-20-14-6-5-12(16)11-13(14)17-15(19)21-10-9-18-7-3-2-4-8-18/h5-6,11H,2-4,7-10H2,1H3,(H,17,19)
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4.20n/an/an/an/an/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 4 receptor in rat striatal membranes by [3H]-GR 113808 displacement.


J Med Chem 40: 1755-61 (1997)


Article DOI: 10.1021/jm960853v
BindingDB Entry DOI: 10.7270/Q2NS0T0C
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM50056403
PNG
(4-Amino-5-chloro-2-methoxy-benzoic acid 2-(3-hydro...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)OCCN1CCCC(O)C1
Show InChI InChI=1S/C15H21ClN2O4/c1-21-14-8-13(17)12(16)7-11(14)15(20)22-6-5-18-4-2-3-10(19)9-18/h7-8,10,19H,2-6,9,17H2,1H3
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4.80n/an/an/an/an/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 4 receptor was determined in rat striatal membranes using [3H]GR-113808 as radioligand


J Med Chem 40: 608-21 (1997)


Article DOI: 10.1021/jm960320m
BindingDB Entry DOI: 10.7270/Q2T72J36
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM50056412
PNG
(4-Amino-5-chloro-2-methoxy-benzoic acid 2-pyrrolid...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)OCCN1CCCC1
Show InChI InChI=1S/C14H19ClN2O3/c1-19-13-9-12(16)11(15)8-10(13)14(18)20-7-6-17-4-2-3-5-17/h8-9H,2-7,16H2,1H3
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5.40n/an/an/an/an/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 4 receptor was determined in rat striatal membranes using [3H]GR-113808 as radioligand


J Med Chem 40: 608-21 (1997)


Article DOI: 10.1021/jm960320m
BindingDB Entry DOI: 10.7270/Q2T72J36
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM50056401
PNG
(2-diethylaminoethyl [2-methoxy-4-amino-5-chloro]be...)
Show SMILES CCN(CC)CCOC(=O)c1cc(Cl)c(N)cc1OC
Show InChI InChI=1S/C14H21ClN2O3/c1-4-17(5-2)6-7-20-14(18)10-8-11(15)12(16)9-13(10)19-3/h8-9H,4-7,16H2,1-3H3
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5.5n/an/an/an/an/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 4 receptor in rat striatal membranes by [3H]-GR 113808 displacement.


J Med Chem 40: 1755-61 (1997)


Article DOI: 10.1021/jm960853v
BindingDB Entry DOI: 10.7270/Q2NS0T0C
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM50056401
PNG
(2-diethylaminoethyl [2-methoxy-4-amino-5-chloro]be...)
Show SMILES CCN(CC)CCOC(=O)c1cc(Cl)c(N)cc1OC
Show InChI InChI=1S/C14H21ClN2O3/c1-4-17(5-2)6-7-20-14(18)10-8-11(15)12(16)9-13(10)19-3/h8-9H,4-7,16H2,1-3H3
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5.5n/an/an/an/an/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 4 receptor was determined in rat striatal membranes using [3H]GR-113808 as radioligand


J Med Chem 40: 608-21 (1997)


Article DOI: 10.1021/jm960320m
BindingDB Entry DOI: 10.7270/Q2T72J36
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM50056402
PNG
(4-Amino-5-chloro-2-methoxy-benzoic acid 2-(3-aza-b...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)OCCN1CC2CCC(CC2)C1
Show InChI InChI=1S/C18H25ClN2O3/c1-23-17-9-16(20)15(19)8-14(17)18(22)24-7-6-21-10-12-2-3-13(11-21)5-4-12/h8-9,12-13H,2-7,10-11,20H2,1H3
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5.5n/an/an/an/an/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 4 receptor was determined in rat striatal membranes using [3H]GR-113808 as radioligand


J Med Chem 40: 608-21 (1997)


Article DOI: 10.1021/jm960320m
BindingDB Entry DOI: 10.7270/Q2T72J36
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM50056409
PNG
(1-[2-(4-Amino-5-chloro-2-methoxy-benzoyloxy)-ethyl...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)OCC[N+]12CCC(CC1)CC2
Show InChI InChI=1S/C17H23ClN2O3/c1-22-16-11-15(19)14(18)10-13(16)17(21)23-9-8-20-5-2-12(3-6-20)4-7-20/h10-12H,2-9H2,1H3,(H-,19,21)/p+1
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6n/an/an/an/an/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 4 receptor was determined in rat striatal membranes using [3H]GR-113808 as radioligand


J Med Chem 40: 608-21 (1997)


Article DOI: 10.1021/jm960320m
BindingDB Entry DOI: 10.7270/Q2T72J36
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM50056395
PNG
(1-[2-(4-Amino-5-chloro-2-methoxy-benzoyloxy)-ethyl...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)OCC[n+]1ccccc1
Show InChI InChI=1S/C15H15ClN2O3/c1-20-14-10-13(17)12(16)9-11(14)15(19)21-8-7-18-5-3-2-4-6-18/h2-6,9-10H,7-8H2,1H3,(H-,17,19)/p+1
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6.20n/an/an/an/an/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 4 receptor was determined in rat striatal membranes using [3H]GR-113808 as radioligand


J Med Chem 40: 608-21 (1997)


Article DOI: 10.1021/jm960320m
BindingDB Entry DOI: 10.7270/Q2T72J36
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM50056422
PNG
(4-Amino-5-chloro-2-methoxy-benzoic acid 2-(2,6-dim...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)OCCN1CC(C)OC(C)C1
Show InChI InChI=1S/C16H23ClN2O4/c1-10-8-19(9-11(2)23-10)4-5-22-16(20)12-6-13(17)14(18)7-15(12)21-3/h6-7,10-11H,4-5,8-9,18H2,1-3H3
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6.30n/an/an/an/an/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 4 receptor was determined in rat striatal membranes using [3H]GR-113808 as radioligand


J Med Chem 40: 608-21 (1997)


Article DOI: 10.1021/jm960320m
BindingDB Entry DOI: 10.7270/Q2T72J36
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM50056420
PNG
(4-Amino-5-chloro-2-methoxy-benzoic acid 2-(4-benzo...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC(CC1)C(=O)c1ccccc1
Show InChI InChI=1S/C22H25ClN2O4/c1-28-20-14-19(24)18(23)13-17(20)22(27)29-12-11-25-9-7-16(8-10-25)21(26)15-5-3-2-4-6-15/h2-6,13-14,16H,7-12,24H2,1H3
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7.60n/an/an/an/an/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 4 receptor was determined in rat striatal membranes using [3H]GR-113808 as radioligand


J Med Chem 40: 608-21 (1997)


Article DOI: 10.1021/jm960320m
BindingDB Entry DOI: 10.7270/Q2T72J36
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM50056398
PNG
(4-Amino-5-chloro-2-methoxy-benzoic acid 2-(2-methy...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)OCCN1CCCCC1C
Show InChI InChI=1S/C16H23ClN2O3/c1-11-5-3-4-6-19(11)7-8-22-16(20)12-9-13(17)14(18)10-15(12)21-2/h9-11H,3-8,18H2,1-2H3
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7.80n/an/an/an/an/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 4 receptor was determined in rat striatal membranes using [3H]GR-113808 as radioligand


J Med Chem 40: 608-21 (1997)


Article DOI: 10.1021/jm960320m
BindingDB Entry DOI: 10.7270/Q2T72J36
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM50058185
PNG
((2-Methoxy-phenyl)-carbamic acid 2-piperidin-1-yl-...)
Show SMILES COc1ccccc1NC(=O)OCCN1CCCCC1
Show InChI InChI=1S/C15H22N2O3/c1-19-14-8-4-3-7-13(14)16-15(18)20-12-11-17-9-5-2-6-10-17/h3-4,7-8H,2,5-6,9-12H2,1H3,(H,16,18)
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8.90n/an/an/an/an/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 4 receptor in rat striatal membranes by [3H]-GR 113808 displacement.


J Med Chem 40: 1755-61 (1997)


Article DOI: 10.1021/jm960853v
BindingDB Entry DOI: 10.7270/Q2NS0T0C
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM50056413
PNG
(4-Amino-5-chloro-2-methoxy-benzoic acid 2-(3,6-dih...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)OCCN1CCC=CC1
Show InChI InChI=1S/C15H19ClN2O3/c1-20-14-10-13(17)12(16)9-11(14)15(19)21-8-7-18-5-3-2-4-6-18/h2-3,9-10H,4-8,17H2,1H3
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9.10n/an/an/an/an/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 4 receptor was determined in rat striatal membranes using [3H]GR-113808 as radioligand


J Med Chem 40: 608-21 (1997)


Article DOI: 10.1021/jm960320m
BindingDB Entry DOI: 10.7270/Q2T72J36
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM50056400
PNG
(4-Amino-5-chloro-2-methoxy-benzoic acid 2-(8-aza-b...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)OCCN1C2CCC1CCC2
Show InChI InChI=1S/C17H23ClN2O3/c1-22-16-10-15(19)14(18)9-13(16)17(21)23-8-7-20-11-3-2-4-12(20)6-5-11/h9-12H,2-8,19H2,1H3
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9.30n/an/an/an/an/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 4 receptor was determined in rat striatal membranes using [3H]GR-113808 as radioligand


J Med Chem 40: 608-21 (1997)


Article DOI: 10.1021/jm960320m
BindingDB Entry DOI: 10.7270/Q2T72J36
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM50058180
PNG
((4-Amino-5-chloro-2-methoxy-phenyl)-carbamic acid ...)
Show SMILES COc1cc(N)c(Cl)cc1NC(=O)OCCN1CCCC(C)C1
Show InChI InChI=1S/C16H24ClN3O3/c1-11-4-3-5-20(10-11)6-7-23-16(21)19-14-8-12(17)13(18)9-15(14)22-2/h8-9,11H,3-7,10,18H2,1-2H3,(H,19,21)
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10.2n/an/an/an/an/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
Binding affinity (Ki+/-SEM) against 5-hydroxytryptamine 4 receptor from cheng Prusoff equation by using [3H]-GR 113808 in rat striatum


J Med Chem 40: 1755-61 (1997)


Article DOI: 10.1021/jm960853v
BindingDB Entry DOI: 10.7270/Q2NS0T0C
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM50058171
PNG
((4-Amino-5-chloro-2-methoxy-phenyl)-carbamic acid ...)
Show SMILES COc1cc(N)c(Cl)cc1NC(=O)OCCN1CCCCCC1
Show InChI InChI=1S/C16H24ClN3O3/c1-22-15-11-13(18)12(17)10-14(15)19-16(21)23-9-8-20-6-4-2-3-5-7-20/h10-11H,2-9,18H2,1H3,(H,19,21)
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14.5n/an/an/an/an/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
Binding affinity (Ki+/-SEM) against 5-hydroxytryptamine 4 receptor from cheng Prusoff equation by using [3H]-GR 113808 in rat striatum


J Med Chem 40: 1755-61 (1997)


Article DOI: 10.1021/jm960853v
BindingDB Entry DOI: 10.7270/Q2NS0T0C
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM50058179
PNG
((4-Amino-5-chloro-2-methoxy-phenyl)-carbamic acid ...)
Show SMILES COc1cc(N)c(Cl)cc1NC(=O)OCCN1CCC(C)CC1
Show InChI InChI=1S/C16H24ClN3O3/c1-11-3-5-20(6-4-11)7-8-23-16(21)19-14-9-12(17)13(18)10-15(14)22-2/h9-11H,3-8,18H2,1-2H3,(H,19,21)
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25.1n/an/an/an/an/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
Binding affinity (Ki+/-SEM) against 5-hydroxytryptamine 4 receptor from cheng Prusoff equation by using [3H]-GR 113808 in rat striatum


J Med Chem 40: 1755-61 (1997)


Article DOI: 10.1021/jm960853v
BindingDB Entry DOI: 10.7270/Q2NS0T0C
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM50056415
PNG
(2-piperidinopropyl 4-amino-5-chloro-2-methoxybenzo...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)OCCCN1CCCCC1
Show InChI InChI=1S/C16H23ClN2O3/c1-21-15-11-14(18)13(17)10-12(15)16(20)22-9-5-8-19-6-3-2-4-7-19/h10-11H,2-9,18H2,1H3
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28n/an/an/an/an/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 4 receptor was determined in rat striatal membranes using [3H]GR-113808 as radioligand


J Med Chem 40: 608-21 (1997)


Article DOI: 10.1021/jm960320m
BindingDB Entry DOI: 10.7270/Q2T72J36
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM50058168
PNG
(CHEMBL48351 | Phenyl-carbamic acid 2-piperidin-1-y...)
Show SMILES O=C(Nc1ccccc1)OCCN1CCCCC1
Show InChI InChI=1S/C14H20N2O2/c17-14(15-13-7-3-1-4-8-13)18-12-11-16-9-5-2-6-10-16/h1,3-4,7-8H,2,5-6,9-12H2,(H,15,17)
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31.7n/an/an/an/an/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 4 receptor in rat striatal membranes by [3H]-GR 113808 displacement.


J Med Chem 40: 1755-61 (1997)


Article DOI: 10.1021/jm960853v
BindingDB Entry DOI: 10.7270/Q2NS0T0C
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM50056414
PNG
(4-Amino-5-chloro-2-methoxy-benzoic acid 2-morpholi...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)OCCN1CCOCC1
Show InChI InChI=1S/C14H19ClN2O4/c1-19-13-9-12(16)11(15)8-10(13)14(18)21-7-4-17-2-5-20-6-3-17/h8-9H,2-7,16H2,1H3
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36n/an/an/an/an/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 4 receptor was determined in rat striatal membranes using [3H]GR-113808 as radioligand


J Med Chem 40: 608-21 (1997)


Article DOI: 10.1021/jm960320m
BindingDB Entry DOI: 10.7270/Q2T72J36
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM50058190
PNG
((4-Amino-5-chloro-2-methoxy-phenyl)-carbamic acid ...)
Show SMILES COc1cc(N)c(Cl)cc1NC(=O)OCCN1CCCCC1
Show InChI InChI=1S/C15H22ClN3O3/c1-21-14-10-12(17)11(16)9-13(14)18-15(20)22-8-7-19-5-3-2-4-6-19/h9-10H,2-8,17H2,1H3,(H,18,20)
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39n/an/an/an/an/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
Binding affinity (Ki+/-SEM) against 5-hydroxytryptamine 4 receptor from cheng Prusoff equation by using [3H]-GR 113808 in rat striatum


J Med Chem 40: 1755-61 (1997)


Article DOI: 10.1021/jm960853v
BindingDB Entry DOI: 10.7270/Q2NS0T0C
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM50056423
PNG
(4-Amino-5-chloro-2-methoxy-benzoic acid 2-(2,6-dim...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)OCCN1C(C)CCCC1C
Show InChI InChI=1S/C17H25ClN2O3/c1-11-5-4-6-12(2)20(11)7-8-23-17(21)13-9-14(18)15(19)10-16(13)22-3/h9-12H,4-8,19H2,1-3H3
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40n/an/an/an/an/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 4 receptor was determined in rat striatal membranes using [3H]GR-113808 as radioligand


J Med Chem 40: 608-21 (1997)


Article DOI: 10.1021/jm960320m
BindingDB Entry DOI: 10.7270/Q2T72J36
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM50056407
PNG
(4-Amino-5-chloro-2-methoxy-benzoic acid 2-dimethyl...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)OCCN(C)C
Show InChI InChI=1S/C12H17ClN2O3/c1-15(2)4-5-18-12(16)8-6-9(13)10(14)7-11(8)17-3/h6-7H,4-5,14H2,1-3H3
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47n/an/an/an/an/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 4 receptor was determined in rat striatal membranes using [3H]GR-113808 as radioligand


J Med Chem 40: 608-21 (1997)


Article DOI: 10.1021/jm960320m
BindingDB Entry DOI: 10.7270/Q2T72J36
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM82519
PNG
(4-amino-5-chloro-2-methoxy-N-(8-methyl-8-azabicycl...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)NC1CC2CCC(C1)N2C
Show InChI InChI=1S/C16H22ClN3O2/c1-20-10-3-4-11(20)6-9(5-10)19-16(21)12-7-13(17)14(18)8-15(12)22-2/h7-11H,3-6,18H2,1-2H3,(H,19,21)
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49n/an/an/an/an/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 4 receptor was determined in rat striatal membranes using [3H]GR-113808 as radioligand


J Med Chem 40: 608-21 (1997)


Article DOI: 10.1021/jm960320m
BindingDB Entry DOI: 10.7270/Q2T72J36
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM50058178
PNG
((3-Chloro-phenyl)-carbamic acid 2-piperidin-1-yl-e...)
Show SMILES Clc1cccc(NC(=O)OCCN2CCCCC2)c1
Show InChI InChI=1S/C14H19ClN2O2/c15-12-5-4-6-13(11-12)16-14(18)19-10-9-17-7-2-1-3-8-17/h4-6,11H,1-3,7-10H2,(H,16,18)
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60.8n/an/an/an/an/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 4 receptor in rat striatal membranes by [3H]-GR 113808 displacement.


J Med Chem 40: 1755-61 (1997)


Article DOI: 10.1021/jm960853v
BindingDB Entry DOI: 10.7270/Q2NS0T0C
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM50056421
PNG
(4-Amino-5-chloro-2-methoxy-benzoic acid 8-methyl-8...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)OC1CC2CCC(C1)N2C
Show InChI InChI=1S/C16H21ClN2O3/c1-19-9-3-4-10(19)6-11(5-9)22-16(20)12-7-13(17)14(18)8-15(12)21-2/h7-11H,3-6,18H2,1-2H3
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64n/an/an/an/an/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 4 receptor was determined in rat striatal membranes using [3H]GR-113808 as radioligand


J Med Chem 40: 608-21 (1997)


Article DOI: 10.1021/jm960320m
BindingDB Entry DOI: 10.7270/Q2T72J36
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM50058189
PNG
((2-Methoxy-phenyl)-carbamic acid 3-piperidin-1-yl-...)
Show SMILES COc1ccccc1NC(=O)OCCCN1CCCCC1
Show InChI InChI=1S/C16H24N2O3/c1-20-15-9-4-3-8-14(15)17-16(19)21-13-7-12-18-10-5-2-6-11-18/h3-4,8-9H,2,5-7,10-13H2,1H3,(H,17,19)
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81n/an/an/an/an/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 4 receptor in rat striatal membranes by [3H]-GR 113808 displacement.


J Med Chem 40: 1755-61 (1997)


Article DOI: 10.1021/jm960853v
BindingDB Entry DOI: 10.7270/Q2NS0T0C
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM50056396
PNG
(4-Amino-5-chloro-2-methoxy-benzoic acid (S)-(1-aza...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)O[C@@H]1CN2CCC1CC2
Show InChI InChI=1S/C15H19ClN2O3/c1-20-13-7-12(17)11(16)6-10(13)15(19)21-14-8-18-4-2-9(14)3-5-18/h6-7,9,14H,2-5,8,17H2,1H3/t14-/m1/s1
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91n/an/an/an/an/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 4 receptor was determined in rat striatal membranes using [3H]GR-113808 as radioligand


J Med Chem 40: 608-21 (1997)


Article DOI: 10.1021/jm960320m
BindingDB Entry DOI: 10.7270/Q2T72J36
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM50056417
PNG
(4-Amino-5-chloro-N-[2-(3,5-dimethyl-piperidin-1-yl...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)NCCN1CC(C)CC(C)C1
Show InChI InChI=1S/C17H26ClN3O2/c1-11-6-12(2)10-21(9-11)5-4-20-17(22)13-7-14(18)15(19)8-16(13)23-3/h7-8,11-12H,4-6,9-10,19H2,1-3H3,(H,20,22)
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103n/an/an/an/an/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 4 receptor was determined in rat striatal membranes using [3H]GR-113808 as radioligand


J Med Chem 40: 608-21 (1997)


Article DOI: 10.1021/jm960320m
BindingDB Entry DOI: 10.7270/Q2T72J36
More data for this
Ligand-Target Pair
HTR4


(RAT)
BDBM50058187
PNG
((4-Amino-5-chloro-2-methoxy-phenyl)-carbamic acid ...)
Show SMILES COc1cc(N)c(Cl)cc1NC(=O)OCCN1CCCC1
Show InChI InChI=1S/C14H20ClN3O3/c1-20-13-9-11(16)10(15)8-12(13)17-14(19)21-7-6-18-4-2-3-5-18/h8-9H,2-7,16H2,1H3,(H,17,19)
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125n/an/an/an/an/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
Binding affinity (Ki+/-SEM) against 5-hydroxytryptamine 4 receptor from cheng Prusoff equation by using [3H]-GR 113808 in rat striatum


J Med Chem 40: 1755-61 (1997)


Article DOI: 10.1021/jm960853v
BindingDB Entry DOI: 10.7270/Q2NS0T0C
More data for this
Ligand-Target Pair
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