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Compile Data Set for Download or QSAR

Found 43 hits from CURIS, INC.   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sonic hedgehog protein


(Mus musculus (Mouse))
BDBM189251
PNG
(US9173869, 5)
Show SMILES Fc1ccc(cc1)-n1c(CNC(=O)Nc2ccc(Cl)c(c2)C(F)(F)F)nc2ccccc2c1=O
Show InChI InChI=1S/C23H15ClF4N4O2/c24-18-10-7-14(11-17(18)23(26,27)28)30-22(34)29-12-20-31-19-4-2-1-3-16(19)21(33)32(20)15-8-5-13(25)6-9-15/h1-11H,12H2,(H2,29,30,34)
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n/an/a<100n/an/an/an/an/an/a



CURIS, INC.

US Patent


Assay Description
Compounds may be tested in the "Gli-Luc" assay below, using the cell line 10T(s12), wherein the cells contain a Hedgehog-responsive reporter construc...


US Patent US9173869 (2015)


BindingDB Entry DOI: 10.7270/Q2Z036X1
More data for this
Ligand-Target Pair
Sonic hedgehog protein


(Mus musculus (Mouse))
BDBM189252
PNG
(US9173869, 6)
Show SMILES Fc1ccc(cc1)-n1c(CNC(=O)Nc2cc(Cl)nc(Cl)c2)nc2ccccc2c1=O
Show InChI InChI=1S/C21H14Cl2FN5O2/c22-17-9-13(10-18(23)28-17)26-21(31)25-11-19-27-16-4-2-1-3-15(16)20(30)29(19)14-7-5-12(24)6-8-14/h1-10H,11H2,(H2,25,26,28,31)
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n/an/a<500n/an/an/an/an/an/a



CURIS, INC.

US Patent


Assay Description
Compounds may be tested in the "Gli-Luc" assay below, using the cell line 10T(s12), wherein the cells contain a Hedgehog-responsive reporter construc...


US Patent US9173869 (2015)


BindingDB Entry DOI: 10.7270/Q2Z036X1
More data for this
Ligand-Target Pair
Sonic hedgehog protein


(Mus musculus (Mouse))
BDBM189289
PNG
(US9173869, 69)
Show SMILES [O-][N+](=O)c1cc(NC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(F)cc2)ccc1Cl
Show InChI InChI=1S/C22H15ClFN5O4/c23-17-10-7-14(11-19(17)29(32)33)26-22(31)25-12-20-27-18-4-2-1-3-16(18)21(30)28(20)15-8-5-13(24)6-9-15/h1-11H,12H2,(H2,25,26,31)
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n/an/a<500n/an/an/an/an/an/a



CURIS, INC.

US Patent


Assay Description
Compounds may be tested in the "Gli-Luc" assay below, using the cell line 10T(s12), wherein the cells contain a Hedgehog-responsive reporter construc...


US Patent US9173869 (2015)


BindingDB Entry DOI: 10.7270/Q2Z036X1
More data for this
Ligand-Target Pair
Sonic hedgehog protein


(Mus musculus (Mouse))
BDBM189268
PNG
(US9173869, 48)
Show SMILES CCC(C)N(CCC(=O)NC1CCCc2ccccc12)C(=O)c1cccc2ccccc12
Show InChI InChI=1S/C28H32N2O2/c1-3-20(2)30(28(32)25-16-8-12-21-10-4-6-14-23(21)25)19-18-27(31)29-26-17-9-13-22-11-5-7-15-24(22)26/h4-8,10-12,14-16,20,26H,3,9,13,17-19H2,1-2H3,(H,29,31)
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n/an/a<500n/an/an/an/an/an/a



CURIS, INC.

US Patent


Assay Description
Compounds may be tested in the "Gli-Luc" assay below, using the cell line 10T(s12), wherein the cells contain a Hedgehog-responsive reporter construc...


US Patent US9173869 (2015)


BindingDB Entry DOI: 10.7270/Q2Z036X1
More data for this
Ligand-Target Pair
Sonic hedgehog protein


(Mus musculus (Mouse))
BDBM189266
PNG
(US9173869, 46)
Show SMILES CCC(N1CCN(C(C)C1)C(=O)c1ccc(cc1)-c1ccccc1)c1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C29H30N4O2/c1-3-26(27-30-25-12-8-7-11-24(25)28(34)31-27)32-17-18-33(20(2)19-32)29(35)23-15-13-22(14-16-23)21-9-5-4-6-10-21/h4-16,20,26H,3,17-19H2,1-2H3,(H,30,31,34)
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n/an/a<500n/an/an/an/an/an/a



CURIS, INC.

US Patent


Assay Description
Compounds may be tested in the "Gli-Luc" assay below, using the cell line 10T(s12), wherein the cells contain a Hedgehog-responsive reporter construc...


US Patent US9173869 (2015)


BindingDB Entry DOI: 10.7270/Q2Z036X1
More data for this
Ligand-Target Pair
Sonic hedgehog protein


(Mus musculus (Mouse))
BDBM189272
PNG
(US9173869, 52)
Show SMILES CC(N(C)C(=O)Nc1cccc(SC(F)(F)F)c1)c1nc2ccccc2c(=O)n1-c1ccc(F)cc1
Show InChI InChI=1S/C25H20F4N4O2S/c1-15(32(2)24(35)30-17-6-5-7-19(14-17)36-25(27,28)29)22-31-21-9-4-3-8-20(21)23(34)33(22)18-12-10-16(26)11-13-18/h3-15H,1-2H3,(H,30,35)
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CURIS, INC.

US Patent


Assay Description
Compounds may be tested in the "Gli-Luc" assay below, using the cell line 10T(s12), wherein the cells contain a Hedgehog-responsive reporter construc...


US Patent US9173869 (2015)


BindingDB Entry DOI: 10.7270/Q2Z036X1
More data for this
Ligand-Target Pair
Sonic hedgehog protein


(Mus musculus (Mouse))
BDBM189288
PNG
(US9173869, 68)
Show SMILES Fc1ccc(cc1)-n1c(CNC(=O)Nc2ccc(Cl)c(Cl)c2)nc2ccccc2c1=O
Show InChI InChI=1S/C22H15Cl2FN4O2/c23-17-10-7-14(11-18(17)24)27-22(31)26-12-20-28-19-4-2-1-3-16(19)21(30)29(20)15-8-5-13(25)6-9-15/h1-11H,12H2,(H2,26,27,31)
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n/an/a<1.00E+3n/an/an/an/an/an/a



CURIS, INC.

US Patent


Assay Description
Compounds may be tested in the "Gli-Luc" assay below, using the cell line 10T(s12), wherein the cells contain a Hedgehog-responsive reporter construc...


US Patent US9173869 (2015)


BindingDB Entry DOI: 10.7270/Q2Z036X1
More data for this
Ligand-Target Pair
Sonic hedgehog protein


(Mus musculus (Mouse))
BDBM189282
PNG
(US9173869, 62)
Show SMILES CC(N(C)C(=O)Nc1ccc(c(Cl)c1)[N+]([O-])=O)c1nc2ccccc2c(=O)n1-c1ccc(F)cc1
Show InChI InChI=1S/C24H19ClFN5O4/c1-14(29(2)24(33)27-16-9-12-21(31(34)35)19(25)13-16)22-28-20-6-4-3-5-18(20)23(32)30(22)17-10-7-15(26)8-11-17/h3-14H,1-2H3,(H,27,33)
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n/an/a<1.00E+3n/an/an/an/an/an/a



CURIS, INC.

US Patent


Assay Description
Compounds may be tested in the "Gli-Luc" assay below, using the cell line 10T(s12), wherein the cells contain a Hedgehog-responsive reporter construc...


US Patent US9173869 (2015)


BindingDB Entry DOI: 10.7270/Q2Z036X1
More data for this
Ligand-Target Pair
Sonic hedgehog protein


(Mus musculus (Mouse))
BDBM189281
PNG
(US9173869, 61)
Show SMILES CC(N(C)C(=O)Nc1ccc(Cl)c(c1)C(F)(F)F)c1nc2ccccc2c(=O)n1-c1ccc(F)cc1
Show InChI InChI=1S/C25H19ClF4N4O2/c1-14(33(2)24(36)31-16-9-12-20(26)19(13-16)25(28,29)30)22-32-21-6-4-3-5-18(21)23(35)34(22)17-10-7-15(27)8-11-17/h3-14H,1-2H3,(H,31,36)
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n/an/a<1.00E+3n/an/an/an/an/an/a



CURIS, INC.

US Patent


Assay Description
Compounds may be tested in the "Gli-Luc" assay below, using the cell line 10T(s12), wherein the cells contain a Hedgehog-responsive reporter construc...


US Patent US9173869 (2015)


BindingDB Entry DOI: 10.7270/Q2Z036X1
More data for this
Ligand-Target Pair
Sonic hedgehog protein


(Mus musculus (Mouse))
BDBM189273
PNG
(US9173869, 53)
Show SMILES CC(N(C)C(=O)Nc1ccc(Cl)c(Cl)c1)c1nc2ccccc2c(=O)n1-c1ccc(F)cc1
Show InChI InChI=1S/C24H19Cl2FN4O2/c1-14(30(2)24(33)28-16-9-12-19(25)20(26)13-16)22-29-21-6-4-3-5-18(21)23(32)31(22)17-10-7-15(27)8-11-17/h3-14H,1-2H3,(H,28,33)
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n/an/a<1.00E+3n/an/an/an/an/an/a



CURIS, INC.

US Patent


Assay Description
Compounds may be tested in the "Gli-Luc" assay below, using the cell line 10T(s12), wherein the cells contain a Hedgehog-responsive reporter construc...


US Patent US9173869 (2015)


BindingDB Entry DOI: 10.7270/Q2Z036X1
More data for this
Ligand-Target Pair
Sonic hedgehog protein


(Mus musculus (Mouse))
BDBM189270
PNG
(US9173869, 50)
Show SMILES Fc1ccc(cc1)-n1c(CCNC(=O)Cc2cccc(c2)C(F)(F)F)nc2ccccc2c1=O
Show InChI InChI=1S/C25H19F4N3O2/c26-18-8-10-19(11-9-18)32-22(31-21-7-2-1-6-20(21)24(32)34)12-13-30-23(33)15-16-4-3-5-17(14-16)25(27,28)29/h1-11,14H,12-13,15H2,(H,30,33)
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n/an/a<1.00E+3n/an/an/an/an/an/a



CURIS, INC.

US Patent


Assay Description
Compounds may be tested in the "Gli-Luc" assay below, using the cell line 10T(s12), wherein the cells contain a Hedgehog-responsive reporter construc...


US Patent US9173869 (2015)


BindingDB Entry DOI: 10.7270/Q2Z036X1
More data for this
Ligand-Target Pair
Sonic hedgehog protein


(Mus musculus (Mouse))
BDBM189269
PNG
(US9173869, 49)
Show SMILES CCC(C)N(CCC(=O)NC1CCCc2ccccc12)C(=O)COc1ccc(Cl)cc1
Show InChI InChI=1S/C25H31ClN2O3/c1-3-18(2)28(25(30)17-31-21-13-11-20(26)12-14-21)16-15-24(29)27-23-10-6-8-19-7-4-5-9-22(19)23/h4-5,7,9,11-14,18,23H,3,6,8,10,15-17H2,1-2H3,(H,27,29)
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n/an/a<1.00E+3n/an/an/an/an/an/a



CURIS, INC.

US Patent


Assay Description
Compounds may be tested in the "Gli-Luc" assay below, using the cell line 10T(s12), wherein the cells contain a Hedgehog-responsive reporter construc...


US Patent US9173869 (2015)


BindingDB Entry DOI: 10.7270/Q2Z036X1
More data for this
Ligand-Target Pair
Sonic hedgehog protein


(Mus musculus (Mouse))
BDBM189264
PNG
(US9173869, 44)
Show SMILES Fc1ccc(cc1)-n1c(CNC(=O)Nc2cccc(c2)C(F)(F)F)nc2ccccc2c1=O
Show InChI InChI=1S/C23H16F4N4O2/c24-15-8-10-17(11-9-15)31-20(30-19-7-2-1-6-18(19)21(31)32)13-28-22(33)29-16-5-3-4-14(12-16)23(25,26)27/h1-12H,13H2,(H2,28,29,33)
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n/an/a<1.00E+3n/an/an/an/an/an/a



CURIS, INC.

US Patent


Assay Description
Compounds may be tested in the "Gli-Luc" assay below, using the cell line 10T(s12), wherein the cells contain a Hedgehog-responsive reporter construc...


US Patent US9173869 (2015)


BindingDB Entry DOI: 10.7270/Q2Z036X1
More data for this
Ligand-Target Pair
Sonic hedgehog protein


(Mus musculus (Mouse))
BDBM189265
PNG
(US9173869, 45)
Show SMILES CCC(N1CCN(C(C)C1)C(=O)Nc1ccc(Cl)c(Cl)c1)c1nc2ccccc2c(=O)[nH]1
Show InChI InChI=1S/C23H25Cl2N5O2/c1-3-20(21-27-19-7-5-4-6-16(19)22(31)28-21)29-10-11-30(14(2)13-29)23(32)26-15-8-9-17(24)18(25)12-15/h4-9,12,14,20H,3,10-11,13H2,1-2H3,(H,26,32)(H,27,28,31)
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n/an/a<5.00E+3n/an/an/an/an/an/a



CURIS, INC.

US Patent


Assay Description
Compounds may be tested in the "Gli-Luc" assay below, using the cell line 10T(s12), wherein the cells contain a Hedgehog-responsive reporter construc...


US Patent US9173869 (2015)


BindingDB Entry DOI: 10.7270/Q2Z036X1
More data for this
Ligand-Target Pair
Sonic hedgehog protein


(Mus musculus (Mouse))
BDBM189257
PNG
(US9173869, 36)
Show SMILES CCCN(C(C)c1nc2ccccc2c(=O)n1-c1ccc(F)cc1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C27H24F4N4O2/c1-3-15-34(26(37)32-20-8-6-7-18(16-20)27(29,30)31)17(2)24-33-23-10-5-4-9-22(23)25(36)35(24)21-13-11-19(28)12-14-21/h4-14,16-17H,3,15H2,1-2H3,(H,32,37)
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CURIS, INC.

US Patent


Assay Description
Compounds may be tested in the "Gli-Luc" assay below, using the cell line 10T(s12), wherein the cells contain a Hedgehog-responsive reporter construc...


US Patent US9173869 (2015)


BindingDB Entry DOI: 10.7270/Q2Z036X1
More data for this
Ligand-Target Pair
Sonic hedgehog protein


(Mus musculus (Mouse))
BDBM189258
PNG
(US9173869, 38)
Show SMILES CCCN(C(C)c1nc2ccccc2c(=O)n1-c1ccc(F)cc1)C(=O)Nc1cccc(OC)c1
Show InChI InChI=1S/C27H27FN4O3/c1-4-16-31(27(34)29-20-8-7-9-22(17-20)35-3)18(2)25-30-24-11-6-5-10-23(24)26(33)32(25)21-14-12-19(28)13-15-21/h5-15,17-18H,4,16H2,1-3H3,(H,29,34)
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CURIS, INC.

US Patent


Assay Description
Compounds may be tested in the "Gli-Luc" assay below, using the cell line 10T(s12), wherein the cells contain a Hedgehog-responsive reporter construc...


US Patent US9173869 (2015)


BindingDB Entry DOI: 10.7270/Q2Z036X1
More data for this
Ligand-Target Pair
Sonic hedgehog protein


(Mus musculus (Mouse))
BDBM189259
PNG
(US9173869, 39)
Show SMILES CCC(N(CCc1ccccc1)C(=O)CCCCF)c1nc2ccccc2c(=O)n1-c1ccc(C)cc1
Show InChI InChI=1S/C31H34FN3O2/c1-3-28(34(29(36)15-9-10-21-32)22-20-24-11-5-4-6-12-24)30-33-27-14-8-7-13-26(27)31(37)35(30)25-18-16-23(2)17-19-25/h4-8,11-14,16-19,28H,3,9-10,15,20-22H2,1-2H3
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CURIS, INC.

US Patent


Assay Description
Compounds may be tested in the "Gli-Luc" assay below, using the cell line 10T(s12), wherein the cells contain a Hedgehog-responsive reporter construc...


US Patent US9173869 (2015)


BindingDB Entry DOI: 10.7270/Q2Z036X1
More data for this
Ligand-Target Pair
Sonic hedgehog protein


(Mus musculus (Mouse))
BDBM189262
PNG
(US9173869, 42)
Show SMILES CCC(N1CCN(CC1C)C(=O)CC)c1nc2ccccc2c(=O)n1-c1ccc(C)cc1
Show InChI InChI=1S/C26H32N4O2/c1-5-23(29-16-15-28(17-19(29)4)24(31)6-2)25-27-22-10-8-7-9-21(22)26(32)30(25)20-13-11-18(3)12-14-20/h7-14,19,23H,5-6,15-17H2,1-4H3
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CURIS, INC.

US Patent


Assay Description
Compounds may be tested in the "Gli-Luc" assay below, using the cell line 10T(s12), wherein the cells contain a Hedgehog-responsive reporter construc...


US Patent US9173869 (2015)


BindingDB Entry DOI: 10.7270/Q2Z036X1
More data for this
Ligand-Target Pair
Sonic hedgehog protein


(Mus musculus (Mouse))
BDBM189291
PNG
(US9173869, 73)
Show SMILES CC(NC(=O)Nc1cccc(c1)C(F)(F)F)c1nc2ccccc2c(=O)n1-c1ccc(F)cc1
Show InChI InChI=1S/C24H18F4N4O2/c1-14(29-23(34)30-17-6-4-5-15(13-17)24(26,27)28)21-31-20-8-3-2-7-19(20)22(33)32(21)18-11-9-16(25)10-12-18/h2-14H,1H3,(H2,29,30,34)
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n/an/a<5.00E+3n/an/an/an/an/an/a



CURIS, INC.

US Patent


Assay Description
Compounds may be tested in the "Gli-Luc" assay below, using the cell line 10T(s12), wherein the cells contain a Hedgehog-responsive reporter construc...


US Patent US9173869 (2015)


BindingDB Entry DOI: 10.7270/Q2Z036X1
More data for this
Ligand-Target Pair
Sonic hedgehog protein


(Mus musculus (Mouse))
BDBM189280
PNG
(US9173869, 60)
Show SMILES CC(N(C)C(=O)Nc1ccc(SC(F)(F)F)cc1)c1nc2ccccc2c(=O)n1-c1ccc(F)cc1
Show InChI InChI=1S/C25H20F4N4O2S/c1-15(32(2)24(35)30-17-9-13-19(14-10-17)36-25(27,28)29)22-31-21-6-4-3-5-20(21)23(34)33(22)18-11-7-16(26)8-12-18/h3-15H,1-2H3,(H,30,35)
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n/an/a<5.00E+3n/an/an/an/an/an/a



CURIS, INC.

US Patent


Assay Description
Compounds may be tested in the "Gli-Luc" assay below, using the cell line 10T(s12), wherein the cells contain a Hedgehog-responsive reporter construc...


US Patent US9173869 (2015)


BindingDB Entry DOI: 10.7270/Q2Z036X1
More data for this
Ligand-Target Pair
Sonic hedgehog protein


(Mus musculus (Mouse))
BDBM189279
PNG
(US9173869, 59)
Show SMILES CC(N(C)C(=O)Nc1cccc(c1C)[N+]([O-])=O)c1nc2ccccc2c(=O)n1-c1ccc(F)cc1
Show InChI InChI=1S/C25H22FN5O4/c1-15-20(9-6-10-22(15)31(34)35)28-25(33)29(3)16(2)23-27-21-8-5-4-7-19(21)24(32)30(23)18-13-11-17(26)12-14-18/h4-14,16H,1-3H3,(H,28,33)
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CURIS, INC.

US Patent


Assay Description
Compounds may be tested in the "Gli-Luc" assay below, using the cell line 10T(s12), wherein the cells contain a Hedgehog-responsive reporter construc...


US Patent US9173869 (2015)


BindingDB Entry DOI: 10.7270/Q2Z036X1
More data for this
Ligand-Target Pair
Sonic hedgehog protein


(Mus musculus (Mouse))
BDBM189278
PNG
(US9173869, 58)
Show SMILES CC(N(C)C(=O)Nc1cc(Cl)nc(Cl)c1)c1nc2ccccc2c(=O)n1-c1ccc(F)cc1
Show InChI InChI=1S/C23H18Cl2FN5O2/c1-13(30(2)23(33)27-15-11-19(24)29-20(25)12-15)21-28-18-6-4-3-5-17(18)22(32)31(21)16-9-7-14(26)8-10-16/h3-13H,1-2H3,(H,27,29,33)
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CURIS, INC.

US Patent


Assay Description
Compounds may be tested in the "Gli-Luc" assay below, using the cell line 10T(s12), wherein the cells contain a Hedgehog-responsive reporter construc...


US Patent US9173869 (2015)


BindingDB Entry DOI: 10.7270/Q2Z036X1
More data for this
Ligand-Target Pair
Sonic hedgehog protein


(Mus musculus (Mouse))
BDBM189275
PNG
(US9173869, 55)
Show SMILES CC(N(C)C(=O)Nc1cccc(F)c1)c1nc2ccccc2c(=O)n1-c1ccc(F)cc1
Show InChI InChI=1S/C24H20F2N4O2/c1-15(29(2)24(32)27-18-7-5-6-17(26)14-18)22-28-21-9-4-3-8-20(21)23(31)30(22)19-12-10-16(25)11-13-19/h3-15H,1-2H3,(H,27,32)
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CURIS, INC.

US Patent


Assay Description
Compounds may be tested in the "Gli-Luc" assay below, using the cell line 10T(s12), wherein the cells contain a Hedgehog-responsive reporter construc...


US Patent US9173869 (2015)


BindingDB Entry DOI: 10.7270/Q2Z036X1
More data for this
Ligand-Target Pair
Sonic hedgehog protein


(Mus musculus (Mouse))
BDBM189274
PNG
(US9173869, 54)
Show SMILES CC(N(C)C(=O)Nc1ccc(cc1)C(F)(F)F)c1nc2ccccc2c(=O)n1-c1ccc(F)cc1
Show InChI InChI=1S/C25H20F4N4O2/c1-15(32(2)24(35)30-18-11-7-16(8-12-18)25(27,28)29)22-31-21-6-4-3-5-20(21)23(34)33(22)19-13-9-17(26)10-14-19/h3-15H,1-2H3,(H,30,35)
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CURIS, INC.

US Patent


Assay Description
Compounds may be tested in the "Gli-Luc" assay below, using the cell line 10T(s12), wherein the cells contain a Hedgehog-responsive reporter construc...


US Patent US9173869 (2015)


BindingDB Entry DOI: 10.7270/Q2Z036X1
More data for this
Ligand-Target Pair
Sonic hedgehog protein


(Mus musculus (Mouse))
BDBM189256
PNG
(US9173869, 34)
Show SMILES CCCN(C(C)c1nc2ccccc2c(=O)n1-c1ccc(F)cc1)C(=O)Nc1cccc(Cl)c1
Show InChI InChI=1S/C26H24ClFN4O2/c1-3-15-31(26(34)29-20-8-6-7-18(27)16-20)17(2)24-30-23-10-5-4-9-22(23)25(33)32(24)21-13-11-19(28)12-14-21/h4-14,16-17H,3,15H2,1-2H3,(H,29,34)
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CURIS, INC.

US Patent


Assay Description
Compounds may be tested in the "Gli-Luc" assay below, using the cell line 10T(s12), wherein the cells contain a Hedgehog-responsive reporter construc...


US Patent US9173869 (2015)


BindingDB Entry DOI: 10.7270/Q2Z036X1
More data for this
Ligand-Target Pair
Sonic hedgehog protein


(Mus musculus (Mouse))
BDBM189255
PNG
(US9173869, 32)
Show SMILES CCN(C(C)c1nc2ccccc2c(=O)n1-c1ccc(F)cc1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C26H22F4N4O2/c1-3-33(25(36)31-19-8-6-7-17(15-19)26(28,29)30)16(2)23-32-22-10-5-4-9-21(22)24(35)34(23)20-13-11-18(27)12-14-20/h4-16H,3H2,1-2H3,(H,31,36)
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CURIS, INC.

US Patent


Assay Description
Compounds may be tested in the "Gli-Luc" assay below, using the cell line 10T(s12), wherein the cells contain a Hedgehog-responsive reporter construc...


US Patent US9173869 (2015)


BindingDB Entry DOI: 10.7270/Q2Z036X1
More data for this
Ligand-Target Pair
Sonic hedgehog protein


(Mus musculus (Mouse))
BDBM189267
PNG
(US9173869, 47)
Show SMILES CCCN(CCC(=O)NC1CCCc2ccccc12)C(=O)c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C25H32N2O4/c1-4-13-27(25(29)19-15-20(30-2)17-21(16-19)31-3)14-12-24(28)26-23-11-7-9-18-8-5-6-10-22(18)23/h5-6,8,10,15-17,23H,4,7,9,11-14H2,1-3H3,(H,26,28)
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CURIS, INC.

US Patent


Assay Description
Compounds may be tested in the "Gli-Luc" assay below, using the cell line 10T(s12), wherein the cells contain a Hedgehog-responsive reporter construc...


US Patent US9173869 (2015)


BindingDB Entry DOI: 10.7270/Q2Z036X1
More data for this
Ligand-Target Pair
Sonic hedgehog protein


(Mus musculus (Mouse))
BDBM189287
PNG
(US9173869, 67)
Show SMILES Cc1c(NC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(F)cc2)cccc1SC(F)(F)F
Show InChI InChI=1S/C24H18F4N4O2S/c1-14-18(7-4-8-20(14)35-24(26,27)28)31-23(34)29-13-21-30-19-6-3-2-5-17(19)22(33)32(21)16-11-9-15(25)10-12-16/h2-12H,13H2,1H3,(H2,29,31,34)
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CURIS, INC.

US Patent


Assay Description
Compounds may be tested in the "Gli-Luc" assay below, using the cell line 10T(s12), wherein the cells contain a Hedgehog-responsive reporter construc...


US Patent US9173869 (2015)


BindingDB Entry DOI: 10.7270/Q2Z036X1
More data for this
Ligand-Target Pair
Sonic hedgehog protein


(Mus musculus (Mouse))
BDBM189292
PNG
(US9173869, 74)
Show SMILES Fc1ccc(cc1)-n1c(CCCNC(=O)Nc2cccc(c2)C(F)(F)F)nc2ccccc2c1=O
Show InChI InChI=1S/C25H20F4N4O2/c26-17-10-12-19(13-11-17)33-22(32-21-8-2-1-7-20(21)23(33)34)9-4-14-30-24(35)31-18-6-3-5-16(15-18)25(27,28)29/h1-3,5-8,10-13,15H,4,9,14H2,(H2,30,31,35)
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CURIS, INC.

US Patent


Assay Description
Compounds may be tested in the "Gli-Luc" assay below, using the cell line 10T(s12), wherein the cells contain a Hedgehog-responsive reporter construc...


US Patent US9173869 (2015)


BindingDB Entry DOI: 10.7270/Q2Z036X1
More data for this
Ligand-Target Pair
Sonic hedgehog protein


(Mus musculus (Mouse))
BDBM189271
PNG
(US9173869, 51)
Show SMILES CC(N(C)C(=O)Nc1cccc(c1)C#N)c1nc2ccccc2c(=O)n1-c1ccc(F)cc1
Show InChI InChI=1S/C25H20FN5O2/c1-16(30(2)25(33)28-19-7-5-6-17(14-19)15-27)23-29-22-9-4-3-8-21(22)24(32)31(23)20-12-10-18(26)11-13-20/h3-14,16H,1-2H3,(H,28,33)
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CURIS, INC.

US Patent


Assay Description
Compounds may be tested in the "Gli-Luc" assay below, using the cell line 10T(s12), wherein the cells contain a Hedgehog-responsive reporter construc...


US Patent US9173869 (2015)


BindingDB Entry DOI: 10.7270/Q2Z036X1
More data for this
Ligand-Target Pair
Sonic hedgehog protein


(Mus musculus (Mouse))
BDBM189293
PNG
(US9173869, 75)
Show SMILES Fc1ccc(cc1)-n1c(nc2ccccc2c1=O)C(NC(=O)Nc1cccc(c1)C(F)(F)F)C1CC1
Show InChI InChI=1S/C26H20F4N4O2/c27-17-10-12-19(13-11-17)34-23(32-21-7-2-1-6-20(21)24(34)35)22(15-8-9-15)33-25(36)31-18-5-3-4-16(14-18)26(28,29)30/h1-7,10-15,22H,8-9H2,(H2,31,33,36)
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CURIS, INC.

US Patent


Assay Description
Compounds may be tested in the "Gli-Luc" assay below, using the cell line 10T(s12), wherein the cells contain a Hedgehog-responsive reporter construc...


US Patent US9173869 (2015)


BindingDB Entry DOI: 10.7270/Q2Z036X1
More data for this
Ligand-Target Pair
Sonic hedgehog protein


(Mus musculus (Mouse))
BDBM189253
PNG
(US9173869, 11)
Show SMILES CC(N(C)C(=O)Nc1cccc(c1)C(F)(F)F)c1nc2ccccc2c(=O)n1-c1ccc(F)cc1
Show InChI InChI=1S/C25H20F4N4O2/c1-15(32(2)24(35)30-18-7-5-6-16(14-18)25(27,28)29)22-31-21-9-4-3-8-20(21)23(34)33(22)19-12-10-17(26)11-13-19/h3-15H,1-2H3,(H,30,35)
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CURIS, INC.

US Patent


Assay Description
Compounds may be tested in the "Gli-Luc" assay below, using the cell line 10T(s12), wherein the cells contain a Hedgehog-responsive reporter construc...


US Patent US9173869 (2015)


BindingDB Entry DOI: 10.7270/Q2Z036X1
More data for this
Ligand-Target Pair
Sonic hedgehog protein


(Mus musculus (Mouse))
BDBM189283
PNG
(US9173869, 63)
Show SMILES CCOC(=O)c1ccccc1NC(=O)N(C)C(C)c1nc2ccccc2c(=O)n1-c1ccc(F)cc1
Show InChI InChI=1S/C27H25FN4O4/c1-4-36-26(34)21-10-6-8-12-23(21)30-27(35)31(3)17(2)24-29-22-11-7-5-9-20(22)25(33)32(24)19-15-13-18(28)14-16-19/h5-17H,4H2,1-3H3,(H,30,35)
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CURIS, INC.

US Patent


Assay Description
Compounds may be tested in the "Gli-Luc" assay below, using the cell line 10T(s12), wherein the cells contain a Hedgehog-responsive reporter construc...


US Patent US9173869 (2015)


BindingDB Entry DOI: 10.7270/Q2Z036X1
More data for this
Ligand-Target Pair
Sonic hedgehog protein


(Mus musculus (Mouse))
BDBM189261
PNG
(US9173869, 41)
Show SMILES CCCCCCCCC(=O)N(CCCCC)C(C)c1nc2ccccc2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C30H41N3O2/c1-4-6-8-9-10-14-22-28(34)32(23-17-7-5-2)24(3)29-31-27-21-16-15-20-26(27)30(35)33(29)25-18-12-11-13-19-25/h11-13,15-16,18-21,24H,4-10,14,17,22-23H2,1-3H3
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CURIS, INC.

US Patent


Assay Description
Compounds may be tested in the "Gli-Luc" assay below, using the cell line 10T(s12), wherein the cells contain a Hedgehog-responsive reporter construc...


US Patent US9173869 (2015)


BindingDB Entry DOI: 10.7270/Q2Z036X1
More data for this
Ligand-Target Pair
Sonic hedgehog protein


(Mus musculus (Mouse))
BDBM189290
PNG
(US9173869, 71)
Show SMILES COc1cccc(NC(=O)NCc2nc3ccccc3c(=O)n2-c2ccc(F)cc2)c1C
Show InChI InChI=1S/C24H21FN4O3/c1-15-19(8-5-9-21(15)32-2)28-24(31)26-14-22-27-20-7-4-3-6-18(20)23(30)29(22)17-12-10-16(25)11-13-17/h3-13H,14H2,1-2H3,(H2,26,28,31)
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CURIS, INC.

US Patent


Assay Description
Compounds may be tested in the "Gli-Luc" assay below, using the cell line 10T(s12), wherein the cells contain a Hedgehog-responsive reporter construc...


US Patent US9173869 (2015)


BindingDB Entry DOI: 10.7270/Q2Z036X1
More data for this
Ligand-Target Pair
Sonic hedgehog protein


(Mus musculus (Mouse))
BDBM189260
PNG
(US9173869, 40)
Show SMILES CCCCc1ccc(cc1)C(=O)N(Cc1ccccc1)C(CC)c1nc2ccccc2c(=O)n1-c1ccc(C)cc1
Show InChI InChI=1S/C36H37N3O2/c1-4-6-12-27-19-21-29(22-20-27)35(40)38(25-28-13-8-7-9-14-28)33(5-2)34-37-32-16-11-10-15-31(32)36(41)39(34)30-23-17-26(3)18-24-30/h7-11,13-24,33H,4-6,12,25H2,1-3H3
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CURIS, INC.

US Patent


Assay Description
Compounds may be tested in the "Gli-Luc" assay below, using the cell line 10T(s12), wherein the cells contain a Hedgehog-responsive reporter construc...


US Patent US9173869 (2015)


BindingDB Entry DOI: 10.7270/Q2Z036X1
More data for this
Ligand-Target Pair
Sonic hedgehog protein


(Mus musculus (Mouse))
BDBM189263
PNG
(US9173869, 43)
Show SMILES CC(N1CCN(CC1)C(=O)Nc1ccc(Cl)c(Cl)c1)c1nc2ccccc2c(=O)n1-c1ccc(F)cc1
Show InChI InChI=1S/C27H24Cl2FN5O2/c1-17(33-12-14-34(15-13-33)27(37)31-19-8-11-22(28)23(29)16-19)25-32-24-5-3-2-4-21(24)26(36)35(25)20-9-6-18(30)7-10-20/h2-11,16-17H,12-15H2,1H3,(H,31,37)
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CURIS, INC.

US Patent


Assay Description
Compounds may be tested in the "Gli-Luc" assay below, using the cell line 10T(s12), wherein the cells contain a Hedgehog-responsive reporter construc...


US Patent US9173869 (2015)


BindingDB Entry DOI: 10.7270/Q2Z036X1
More data for this
Ligand-Target Pair
Sonic hedgehog protein


(Mus musculus (Mouse))
BDBM189286
PNG
(US9173869, 66)
Show SMILES CC(N(C)C(=O)Nc1ccc(Cl)cc1[N+]([O-])=O)c1nc2ccccc2c(=O)n1-c1ccc(F)cc1
Show InChI InChI=1S/C24H19ClFN5O4/c1-14(29(2)24(33)28-20-12-7-15(25)13-21(20)31(34)35)22-27-19-6-4-3-5-18(19)23(32)30(22)17-10-8-16(26)9-11-17/h3-14H,1-2H3,(H,28,33)
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CURIS, INC.

US Patent


Assay Description
Compounds may be tested in the "Gli-Luc" assay below, using the cell line 10T(s12), wherein the cells contain a Hedgehog-responsive reporter construc...


US Patent US9173869 (2015)


BindingDB Entry DOI: 10.7270/Q2Z036X1
More data for this
Ligand-Target Pair
Sonic hedgehog protein


(Mus musculus (Mouse))
BDBM189254
PNG
(US9173869, 31)
Show SMILES CC(N(Cc1ccco1)C(=O)Nc1cccc(F)c1)c1nc2ccccc2c(=O)n1-c1ccc(F)cc1
Show InChI InChI=1S/C28H22F2N4O3/c1-18(33(17-23-8-5-15-37-23)28(36)31-21-7-4-6-20(30)16-21)26-32-25-10-3-2-9-24(25)27(35)34(26)22-13-11-19(29)12-14-22/h2-16,18H,17H2,1H3,(H,31,36)
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CURIS, INC.

US Patent


Assay Description
Compounds may be tested in the "Gli-Luc" assay below, using the cell line 10T(s12), wherein the cells contain a Hedgehog-responsive reporter construc...


US Patent US9173869 (2015)


BindingDB Entry DOI: 10.7270/Q2Z036X1
More data for this
Ligand-Target Pair
Sonic hedgehog protein


(Mus musculus (Mouse))
BDBM189277
PNG
(US9173869, 57)
Show SMILES CC(C)c1cccc(NC(=O)N(C)C(C)c2nc3ccccc3c(=O)n2-c2ccc(F)cc2)c1
Show InChI InChI=1S/C27H27FN4O2/c1-17(2)19-8-7-9-21(16-19)29-27(34)31(4)18(3)25-30-24-11-6-5-10-23(24)26(33)32(25)22-14-12-20(28)13-15-22/h5-18H,1-4H3,(H,29,34)
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CURIS, INC.

US Patent


Assay Description
Compounds may be tested in the "Gli-Luc" assay below, using the cell line 10T(s12), wherein the cells contain a Hedgehog-responsive reporter construc...


US Patent US9173869 (2015)


BindingDB Entry DOI: 10.7270/Q2Z036X1
More data for this
Ligand-Target Pair
Sonic hedgehog protein


(Mus musculus (Mouse))
BDBM189276
PNG
(US9173869, 56)
Show SMILES CC(N(C)C(=O)Nc1ccc(cc1)-c1ccccc1)c1nc2ccccc2c(=O)n1-c1ccc(F)cc1
Show InChI InChI=1S/C30H25FN4O2/c1-20(34(2)30(37)32-24-16-12-22(13-17-24)21-8-4-3-5-9-21)28-33-27-11-7-6-10-26(27)29(36)35(28)25-18-14-23(31)15-19-25/h3-20H,1-2H3,(H,32,37)
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CURIS, INC.

US Patent


Assay Description
Compounds may be tested in the "Gli-Luc" assay below, using the cell line 10T(s12), wherein the cells contain a Hedgehog-responsive reporter construc...


US Patent US9173869 (2015)


BindingDB Entry DOI: 10.7270/Q2Z036X1
More data for this
Ligand-Target Pair
Sonic hedgehog protein


(Mus musculus (Mouse))
BDBM189284
PNG
(US9173869, 64)
Show SMILES CC(N(C)C(=O)Nc1ccc(cc1Cl)[N+]([O-])=O)c1nc2ccccc2c(=O)n1-c1ccc(F)cc1
Show InChI InChI=1S/C24H19ClFN5O4/c1-14(29(2)24(33)28-21-12-11-17(31(34)35)13-19(21)25)22-27-20-6-4-3-5-18(20)23(32)30(22)16-9-7-15(26)8-10-16/h3-14H,1-2H3,(H,28,33)
PDB

UniProtKB/SwissProt

GoogleScholar
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PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<1.00E+4n/an/an/an/an/an/a



CURIS, INC.

US Patent


Assay Description
Compounds may be tested in the "Gli-Luc" assay below, using the cell line 10T(s12), wherein the cells contain a Hedgehog-responsive reporter construc...


US Patent US9173869 (2015)


BindingDB Entry DOI: 10.7270/Q2Z036X1
More data for this
Ligand-Target Pair
Sonic hedgehog protein


(Mus musculus (Mouse))
BDBM189285
PNG
(US9173869, 65)
Show SMILES CCOOC(=O)c1cccc(NC(=O)N(C)C(C)c2nc3ccccc3c(=O)n2-c2ccc(F)cc2)c1
Show InChI InChI=1S/C27H25FN4O5/c1-4-36-37-26(34)18-8-7-9-20(16-18)29-27(35)31(3)17(2)24-30-23-11-6-5-10-22(23)25(33)32(24)21-14-12-19(28)13-15-21/h5-17H,4H2,1-3H3,(H,29,35)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<1.00E+4n/an/an/an/an/an/a



CURIS, INC.

US Patent


Assay Description
Compounds may be tested in the "Gli-Luc" assay below, using the cell line 10T(s12), wherein the cells contain a Hedgehog-responsive reporter construc...


US Patent US9173869 (2015)


BindingDB Entry DOI: 10.7270/Q2Z036X1
More data for this
Ligand-Target Pair