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Compile Data Set for Download or QSAR

Found 153 hits from Cambridge NeuroScience, Inc.   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sigma non-opioid intracellular receptor 1


(HUMAN)
BDBM50061754
PNG
(CHEMBL542487 | N-(2-Chloro-3,5-diethyl-phenyl)-N'-...)
Show SMILES CCc1cccc(NC(N)=Nc2cc(CC)cc(CC)c2Cl)c1
Show InChI InChI=1S/C19H24ClN3/c1-4-13-8-7-9-16(11-13)22-19(21)23-17-12-14(5-2)10-15(6-3)18(17)20/h7-12H,4-6H2,1-3H3,(H3,21,22,23)
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n/an/a 4.5n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Binding assay for the sigma receptor sites is performed by utilizing [3H]N,N-di-o-tolylguanidine ([3H]DTG) and guinea pig brain membrane suspensions


J Med Chem 40: 4281-9 (1998)


Article DOI: 10.1021/jm970459c
BindingDB Entry DOI: 10.7270/Q2G161HQ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(HUMAN)
BDBM50061768
PNG
(CHEMBL553034 | N-(2-Bromo-3,5-diethyl-phenyl)-N'-(...)
Show SMILES CCc1cccc(NC(N)=Nc2cc(CC)cc(CC)c2Br)c1
Show InChI InChI=1S/C19H24BrN3/c1-4-13-8-7-9-16(11-13)22-19(21)23-17-12-14(5-2)10-15(6-3)18(17)20/h7-12H,4-6H2,1-3H3,(H3,21,22,23)
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n/an/a 5.70n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Binding assay for the sigma receptor sites is performed by utilizing [3H]N,N-di-o-tolylguanidine ([3H]DTG) and guinea pig brain membrane suspensions


J Med Chem 40: 4281-9 (1998)


Article DOI: 10.1021/jm970459c
BindingDB Entry DOI: 10.7270/Q2G161HQ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(HUMAN)
BDBM50061773
PNG
(CHEMBL552829 | N-(3,5-Diethyl-2-fluoro-phenyl)-N'-...)
Show SMILES CCc1cccc(NC(N)=Nc2cc(CC)cc(CC)c2F)c1
Show InChI InChI=1S/C19H24FN3/c1-4-13-8-7-9-16(11-13)22-19(21)23-17-12-14(5-2)10-15(6-3)18(17)20/h7-12H,4-6H2,1-3H3,(H3,21,22,23)
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n/an/a 7.40n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Binding assay for the sigma receptor sites is performed by utilizing [3H]N,N-di-o-tolylguanidine ([3H]DTG) and guinea pig brain membrane suspensions


J Med Chem 40: 4281-9 (1998)


Article DOI: 10.1021/jm970459c
BindingDB Entry DOI: 10.7270/Q2G161HQ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(HUMAN)
BDBM50010747
PNG
(CHEMBL543201 | CHEMBL78777 | N,N'-Bis-(3-ethyl-phe...)
Show SMILES CCc1cccc(NC(N)=Nc2cccc(CC)c2)c1
Show InChI InChI=1S/C17H21N3/c1-3-13-7-5-9-15(11-13)19-17(18)20-16-10-6-8-14(4-2)12-16/h5-12H,3-4H2,1-2H3,(H3,18,19,20)
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n/an/a 8n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane


J Med Chem 37: 260-7 (1994)


Article DOI: 10.1021/jm00028a009
BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(HUMAN)
BDBM50061807
PNG
(CHEMBL552831 | N-(3,5-Diethyl-phenyl)-N'-(3-ethyl-...)
Show SMILES CCc1cccc(NC(N)=Nc2cc(CC)cc(CC)c2)c1
Show InChI InChI=1S/C19H25N3/c1-4-14-8-7-9-17(11-14)21-19(20)22-18-12-15(5-2)10-16(6-3)13-18/h7-13H,4-6H2,1-3H3,(H3,20,21,22)
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n/an/a 8n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Binding assay for the sigma receptor sites is performed by utilizing [3H]N,N-di-o-tolylguanidine ([3H]DTG) and guinea pig brain membrane suspensions


J Med Chem 40: 4281-9 (1998)


Article DOI: 10.1021/jm970459c
BindingDB Entry DOI: 10.7270/Q2G161HQ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(HUMAN)
BDBM50061756
PNG
(CHEMBL544842 | N-(3-Bromo-phenyl)-N'-(3-ethyl-phen...)
Show SMILES CCc1cccc(NC(N)=Nc2cccc(Br)c2)c1
Show InChI InChI=1S/C15H16BrN3/c1-2-11-5-3-7-13(9-11)18-15(17)19-14-8-4-6-12(16)10-14/h3-10H,2H2,1H3,(H3,17,18,19)
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n/an/a 10n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Binding assay for the sigma receptor sites is performed by utilizing [3H]N,N-di-o-tolylguanidine ([3H]DTG) and guinea pig brain membrane suspensions


J Med Chem 40: 4281-9 (1998)


Article DOI: 10.1021/jm970459c
BindingDB Entry DOI: 10.7270/Q2G161HQ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(HUMAN)
BDBM50061746
PNG
(CHEMBL556043 | N-(3-Ethyl-phenyl)-N'-o-tolyl-guani...)
Show SMILES CCc1cccc(NC(N)=Nc2ccccc2C)c1
Show InChI InChI=1S/C16H19N3/c1-3-13-8-6-9-14(11-13)18-16(17)19-15-10-5-4-7-12(15)2/h4-11H,3H2,1-2H3,(H3,17,18,19)
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n/an/a 11n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Binding assay for the sigma receptor sites is performed by utilizing [3H]N,N-di-o-tolylguanidine ([3H]DTG) and guinea pig brain membrane suspensions


J Med Chem 40: 4281-9 (1998)


Article DOI: 10.1021/jm970459c
BindingDB Entry DOI: 10.7270/Q2G161HQ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(HUMAN)
BDBM50061776
PNG
(CHEMBL553312 | N-(2,5-Dichloro-phenyl)-N'-(3-ethyl...)
Show SMILES CCc1cccc(NC(N)=Nc2cc(Cl)ccc2Cl)c1
Show InChI InChI=1S/C15H15Cl2N3/c1-2-10-4-3-5-12(8-10)19-15(18)20-14-9-11(16)6-7-13(14)17/h3-9H,2H2,1H3,(H3,18,19,20)
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n/an/a 12n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Binding assay for the sigma receptor sites is performed by utilizing [3H]N,N-di-o-tolylguanidine ([3H]DTG) and guinea pig brain membrane suspensions


J Med Chem 40: 4281-9 (1998)


Article DOI: 10.1021/jm970459c
BindingDB Entry DOI: 10.7270/Q2G161HQ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(HUMAN)
BDBM50010758
PNG
(CHEMBL312600 | N,N'-Bis-(2-iodo-phenyl)-guanidine)
Show SMILES NC(Nc1ccccc1I)=Nc1ccccc1I
Show InChI InChI=1S/C13H11I2N3/c14-9-5-1-3-7-11(9)17-13(16)18-12-8-4-2-6-10(12)15/h1-8H,(H3,16,17,18)
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n/an/a 13n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane


J Med Chem 37: 260-7 (1994)


Article DOI: 10.1021/jm00028a009
BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(HUMAN)
BDBM50061805
PNG
(CHEMBL542491 | N-(2,3-Dichloro-phenyl)-N'-(3-ethyl...)
Show SMILES CCc1cccc(NC(N)=Nc2cccc(Cl)c2Cl)c1
Show InChI InChI=1S/C15H15Cl2N3/c1-2-10-5-3-6-11(9-10)19-15(18)20-13-8-4-7-12(16)14(13)17/h3-9H,2H2,1H3,(H3,18,19,20)
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n/an/a 13n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Binding assay for the sigma receptor sites is performed by utilizing [3H]N,N-di-o-tolylguanidine ([3H]DTG) and guinea pig brain membrane suspensions


J Med Chem 40: 4281-9 (1998)


Article DOI: 10.1021/jm970459c
BindingDB Entry DOI: 10.7270/Q2G161HQ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(HUMAN)
BDBM50010760
PNG
(CHEMBL310170 | N,N'-Bis-(2-ethyl-phenyl)-guanidine)
Show SMILES CCc1ccccc1NC(N)=Nc1ccccc1CC
Show InChI InChI=1S/C17H21N3/c1-3-13-9-5-7-11-15(13)19-17(18)20-16-12-8-6-10-14(16)4-2/h5-12H,3-4H2,1-2H3,(H3,18,19,20)
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n/an/a 14n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane


J Med Chem 37: 260-7 (1994)


Article DOI: 10.1021/jm00028a009
BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(HUMAN)
BDBM50061806
PNG
(CHEMBL543433 | N-(2,6-Dichloro-phenyl)-N'-(3-ethyl...)
Show SMILES CCc1cccc(NC(N)=Nc2c(Cl)cccc2Cl)c1
Show InChI InChI=1S/C15H15Cl2N3/c1-2-10-5-3-6-11(9-10)19-15(18)20-14-12(16)7-4-8-13(14)17/h3-9H,2H2,1H3,(H3,18,19,20)
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n/an/a 14n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Binding assay for the sigma receptor sites is performed by utilizing [3H]N,N-di-o-tolylguanidine ([3H]DTG) and guinea pig brain membrane suspensions


J Med Chem 40: 4281-9 (1998)


Article DOI: 10.1021/jm970459c
BindingDB Entry DOI: 10.7270/Q2G161HQ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(HUMAN)
BDBM50061766
PNG
(CHEMBL545310 | N-(2-Chloro-phenyl)-N'-(3-ethyl-phe...)
Show SMILES CCc1cccc(NC(N)=Nc2ccccc2Cl)c1
Show InChI InChI=1S/C15H16ClN3/c1-2-11-6-5-7-12(10-11)18-15(17)19-14-9-4-3-8-13(14)16/h3-10H,2H2,1H3,(H3,17,18,19)
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n/an/a 16n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Binding assay for the sigma receptor sites is performed by utilizing [3H]N,N-di-o-tolylguanidine ([3H]DTG) and guinea pig brain membrane suspensions


J Med Chem 40: 4281-9 (1998)


Article DOI: 10.1021/jm970459c
BindingDB Entry DOI: 10.7270/Q2G161HQ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(HUMAN)
BDBM50061795
PNG
(CHEMBL543427 | N-(2-Chloro-3-ethyl-5-methylsulfany...)
Show SMILES CCc1cccc(NC(N)=Nc2cc(SC)cc(CC)c2Cl)c1
Show InChI InChI=1S/C18H22ClN3S/c1-4-12-7-6-8-14(9-12)21-18(20)22-16-11-15(23-3)10-13(5-2)17(16)19/h6-11H,4-5H2,1-3H3,(H3,20,21,22)
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n/an/a 16n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Binding assay for the sigma receptor sites is performed by utilizing [3H]N,N-di-o-tolylguanidine ([3H]DTG) and guinea pig brain membrane suspensions


J Med Chem 40: 4281-9 (1998)


Article DOI: 10.1021/jm970459c
BindingDB Entry DOI: 10.7270/Q2G161HQ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(HUMAN)
BDBM50061739
PNG
(CHEMBL542736 | N-(2-Chloro-3-ethyl-5-trifluorometh...)
Show SMILES CCc1cccc(NC(N)=Nc2cc(cc(CC)c2Cl)C(F)(F)F)c1
Show InChI InChI=1S/C18H19ClF3N3/c1-3-11-6-5-7-14(8-11)24-17(23)25-15-10-13(18(20,21)22)9-12(4-2)16(15)19/h5-10H,3-4H2,1-2H3,(H3,23,24,25)
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n/an/a 17n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Binding assay for the sigma receptor sites is performed by utilizing [3H]N,N-di-o-tolylguanidine ([3H]DTG) and guinea pig brain membrane suspensions


J Med Chem 40: 4281-9 (1998)


Article DOI: 10.1021/jm970459c
BindingDB Entry DOI: 10.7270/Q2G161HQ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(HUMAN)
BDBM50061778
PNG
(CHEMBL542481 | N-(2,5-Dibromo-3-ethyl-phenyl)-N'-(...)
Show SMILES CCc1cccc(NC(N)=Nc2cc(Br)cc(CC)c2Br)c1
Show InChI InChI=1S/C17H19Br2N3/c1-3-11-6-5-7-14(8-11)21-17(20)22-15-10-13(18)9-12(4-2)16(15)19/h5-10H,3-4H2,1-2H3,(H3,20,21,22)
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n/an/a 18n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Binding assay for the sigma receptor sites is performed by utilizing [3H]N,N-di-o-tolylguanidine ([3H]DTG) and guinea pig brain membrane suspensions


J Med Chem 40: 4281-9 (1998)


Article DOI: 10.1021/jm970459c
BindingDB Entry DOI: 10.7270/Q2G161HQ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(HUMAN)
BDBM50061764
PNG
(CHEMBL538036 | N-(2-Ethyl-phenyl)-N'-(3-ethyl-phen...)
Show SMILES CCc1cccc(NC(N)=Nc2ccccc2CC)c1
Show InChI InChI=1S/C17H21N3/c1-3-13-8-7-10-15(12-13)19-17(18)20-16-11-6-5-9-14(16)4-2/h5-12H,3-4H2,1-2H3,(H3,18,19,20)
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n/an/a 19n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Binding assay for the sigma receptor sites is performed by utilizing [3H]N,N-di-o-tolylguanidine ([3H]DTG) and guinea pig brain membrane suspensions


J Med Chem 40: 4281-9 (1998)


Article DOI: 10.1021/jm970459c
BindingDB Entry DOI: 10.7270/Q2G161HQ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(HUMAN)
BDBM50061744
PNG
(CHEMBL553749 | N-(2-Bromo-3-ethyl-5-trifluoromethy...)
Show SMILES CCc1cccc(NC(N)=Nc2cc(cc(CC)c2Br)C(F)(F)F)c1
Show InChI InChI=1S/C18H19BrF3N3/c1-3-11-6-5-7-14(8-11)24-17(23)25-15-10-13(18(20,21)22)9-12(4-2)16(15)19/h5-10H,3-4H2,1-2H3,(H3,23,24,25)
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n/an/a 20n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Binding assay for the sigma receptor sites is performed by utilizing [3H]N,N-di-o-tolylguanidine ([3H]DTG) and guinea pig brain membrane suspensions


J Med Chem 40: 4281-9 (1998)


Article DOI: 10.1021/jm970459c
BindingDB Entry DOI: 10.7270/Q2G161HQ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(HUMAN)
BDBM50061741
PNG
(CHEMBL543432 | N-(4-Chloro-phenyl)-N'-(3-ethyl-phe...)
Show SMILES CCc1cccc(c1)N=C(N)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C15H16ClN3/c1-2-11-4-3-5-14(10-11)19-15(17)18-13-8-6-12(16)7-9-13/h3-10H,2H2,1H3,(H3,17,18,19)
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n/an/a 20n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Binding assay for the sigma receptor sites is performed by utilizing [3H]N,N-di-o-tolylguanidine ([3H]DTG) and guinea pig brain membrane suspensions


J Med Chem 40: 4281-9 (1998)


Article DOI: 10.1021/jm970459c
BindingDB Entry DOI: 10.7270/Q2G161HQ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(HUMAN)
BDBM50061770
PNG
(CHEMBL541860 | N-(3-Ethyl-phenyl)-N'-(2-isopropyl-...)
Show SMILES CCc1cccc(NC(N)=Nc2ccccc2C(C)C)c1
Show InChI InChI=1S/C18H23N3/c1-4-14-8-7-9-15(12-14)20-18(19)21-17-11-6-5-10-16(17)13(2)3/h5-13H,4H2,1-3H3,(H3,19,20,21)
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n/an/a 21n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Binding assay for the sigma receptor sites is performed by utilizing [3H]N,N-di-o-tolylguanidine ([3H]DTG) and guinea pig brain membrane suspensions


J Med Chem 40: 4281-9 (1998)


Article DOI: 10.1021/jm970459c
BindingDB Entry DOI: 10.7270/Q2G161HQ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(HUMAN)
BDBM50061755
PNG
(CHEMBL540841 | N-(3-Ethyl-2-fluoro-5-trifluorometh...)
Show SMILES CCc1cccc(NC(N)=Nc2cc(cc(CC)c2F)C(F)(F)F)c1
Show InChI InChI=1S/C18H19F4N3/c1-3-11-6-5-7-14(8-11)24-17(23)25-15-10-13(18(20,21)22)9-12(4-2)16(15)19/h5-10H,3-4H2,1-2H3,(H3,23,24,25)
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n/an/a 24n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Binding assay for the sigma receptor sites is performed by utilizing [3H]N,N-di-o-tolylguanidine ([3H]DTG) and guinea pig brain membrane suspensions


J Med Chem 40: 4281-9 (1998)


Article DOI: 10.1021/jm970459c
BindingDB Entry DOI: 10.7270/Q2G161HQ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(HUMAN)
BDBM50061783
PNG
(CHEMBL554355 | N-(3-Chloro-phenyl)-N'-(3-ethyl-phe...)
Show SMILES CCc1cccc(NC(N)=Nc2cccc(Cl)c2)c1
Show InChI InChI=1S/C15H16ClN3/c1-2-11-5-3-7-13(9-11)18-15(17)19-14-8-4-6-12(16)10-14/h3-10H,2H2,1H3,(H3,17,18,19)
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n/an/a 27n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Binding assay for the sigma receptor sites is performed by utilizing [3H]N,N-di-o-tolylguanidine ([3H]DTG) and guinea pig brain membrane suspensions


J Med Chem 40: 4281-9 (1998)


Article DOI: 10.1021/jm970459c
BindingDB Entry DOI: 10.7270/Q2G161HQ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(HUMAN)
BDBM50061745
PNG
(CHEMBL543673 | N'-(2,5-Dichloro-phenyl)-N-(3-ethyl...)
Show SMILES CCc1cccc(c1)N(C)C(N)=Nc1cc(Cl)ccc1Cl
Show InChI InChI=1S/C16H17Cl2N3/c1-3-11-5-4-6-13(9-11)21(2)16(19)20-15-10-12(17)7-8-14(15)18/h4-10H,3H2,1-2H3,(H2,19,20)
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n/an/a 29n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Binding assay for the sigma receptor sites is performed by utilizing [3H]N,N-di-o-tolylguanidine ([3H]DTG) and guinea pig brain membrane suspensions


J Med Chem 40: 4281-9 (1998)


Article DOI: 10.1021/jm970459c
BindingDB Entry DOI: 10.7270/Q2G161HQ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(HUMAN)
BDBM50043978
PNG
(CHEMBL315051 | N,N'-Di-indan-4-yl-guanidine)
Show SMILES NC(Nc1cccc2CCCc12)=Nc1cccc2CCCc12
Show InChI InChI=1S/C19H21N3/c20-19(21-17-11-3-7-13-5-1-9-15(13)17)22-18-12-4-8-14-6-2-10-16(14)18/h3-4,7-8,11-12H,1-2,5-6,9-10H2,(H3,20,21,22)
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n/an/a 29n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane


J Med Chem 37: 260-7 (1994)


Article DOI: 10.1021/jm00028a009
BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(HUMAN)
BDBM50010747
PNG
(CHEMBL543201 | CHEMBL78777 | N,N'-Bis-(3-ethyl-phe...)
Show SMILES CCc1cccc(NC(N)=Nc2cccc(CC)c2)c1
Show InChI InChI=1S/C17H21N3/c1-3-13-7-5-9-15(11-13)19-17(18)20-16-10-6-8-14(4-2)12-16/h5-12H,3-4H2,1-2H3,(H3,18,19,20)
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n/an/a 30n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Binding assay for the sigma receptor sites is performed by utilizing [3H]N,N-di-o-tolylguanidine ([3H]DTG) and guinea pig brain membrane suspensions


J Med Chem 40: 4281-9 (1998)


Article DOI: 10.1021/jm970459c
BindingDB Entry DOI: 10.7270/Q2G161HQ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(HUMAN)
BDBM81982
PNG
(CAS_97-39-2 | DITOLYLGUANIDINE | DTG | Di-o-tolylg...)
Show SMILES Cc1ccccc1NC(N)=Nc1ccccc1C
Show InChI InChI=1S/C15H17N3/c1-11-7-3-5-9-13(11)17-15(16)18-14-10-6-4-8-12(14)2/h3-10H,1-2H3,(H3,16,17,18)
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n/an/a 31n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane


J Med Chem 37: 260-7 (1994)


Article DOI: 10.1021/jm00028a009
BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(HUMAN)
BDBM50061762
PNG
(CHEMBL542730 | N-(2-Chloro-3-ethyl-5-methyl-phenyl...)
Show SMILES CCc1cccc(NC(N)=Nc2cc(C)cc(CC)c2Cl)c1
Show InChI InChI=1S/C18H22ClN3/c1-4-13-7-6-8-15(11-13)21-18(20)22-16-10-12(3)9-14(5-2)17(16)19/h6-11H,4-5H2,1-3H3,(H3,20,21,22)
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n/an/a 31n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Binding assay for the sigma receptor sites is performed by utilizing [3H]N,N-di-o-tolylguanidine ([3H]DTG) and guinea pig brain membrane suspensions


J Med Chem 40: 4281-9 (1998)


Article DOI: 10.1021/jm970459c
BindingDB Entry DOI: 10.7270/Q2G161HQ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(HUMAN)
BDBM50061788
PNG
(CHEMBL543431 | N-(3,4-Dichloro-phenyl)-N'-(3-ethyl...)
Show SMILES CCc1cccc(NC(N)=Nc2ccc(Cl)c(Cl)c2)c1
Show InChI InChI=1S/C15H15Cl2N3/c1-2-10-4-3-5-11(8-10)19-15(18)20-12-6-7-13(16)14(17)9-12/h3-9H,2H2,1H3,(H3,18,19,20)
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n/an/a 32n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Binding assay for the sigma receptor sites is performed by utilizing [3H]N,N-di-o-tolylguanidine ([3H]DTG) and guinea pig brain membrane suspensions


J Med Chem 40: 4281-9 (1998)


Article DOI: 10.1021/jm970459c
BindingDB Entry DOI: 10.7270/Q2G161HQ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(HUMAN)
BDBM50010784
PNG
(CHEMBL81070 | N,N'-Bis-(4-bromo-phenyl)-guanidine)
Show SMILES NC(Nc1ccc(Br)cc1)=Nc1ccc(Br)cc1
Show InChI InChI=1S/C13H11Br2N3/c14-9-1-5-11(6-2-9)17-13(16)18-12-7-3-10(15)4-8-12/h1-8H,(H3,16,17,18)
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n/an/a 33n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane


J Med Chem 37: 260-7 (1994)


Article DOI: 10.1021/jm00028a009
BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(HUMAN)
BDBM50061794
PNG
(CHEMBL539299 | N-(2,4-Dichloro-phenyl)-N'-(3-ethyl...)
Show SMILES CCc1cccc(NC(N)=Nc2ccc(Cl)cc2Cl)c1
Show InChI InChI=1S/C15H15Cl2N3/c1-2-10-4-3-5-12(8-10)19-15(18)20-14-7-6-11(16)9-13(14)17/h3-9H,2H2,1H3,(H3,18,19,20)
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n/an/a 37n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Binding assay for the sigma receptor sites is performed by utilizing [3H]N,N-di-o-tolylguanidine ([3H]DTG) and guinea pig brain membrane suspensions


J Med Chem 40: 4281-9 (1998)


Article DOI: 10.1021/jm970459c
BindingDB Entry DOI: 10.7270/Q2G161HQ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(HUMAN)
BDBM50061763
PNG
(CHEMBL545545 | N'-(3,4-Dichloro-phenyl)-N-(3-ethyl...)
Show SMILES CCc1cccc(c1)N(C)C(N)=Nc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H17Cl2N3/c1-3-11-5-4-6-13(9-11)21(2)16(19)20-12-7-8-14(17)15(18)10-12/h4-10H,3H2,1-2H3,(H2,19,20)
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n/an/a 39n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Binding assay for the sigma receptor sites is performed by utilizing [3H]N,N-di-o-tolylguanidine ([3H]DTG) and guinea pig brain membrane suspensions


J Med Chem 40: 4281-9 (1998)


Article DOI: 10.1021/jm970459c
BindingDB Entry DOI: 10.7270/Q2G161HQ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(HUMAN)
BDBM50061789
PNG
(CHEMBL542956 | N-(2,5-Dichloro-phenyl)-N'-(3-ethyl...)
Show SMILES CCc1cccc(c1)N(C)C(=N)N(C)c1cc(Cl)ccc1Cl
Show InChI InChI=1S/C17H19Cl2N3/c1-4-12-6-5-7-14(10-12)21(2)17(20)22(3)16-11-13(18)8-9-15(16)19/h5-11,20H,4H2,1-3H3
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n/an/a 39n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Binding assay for the sigma receptor sites is performed by utilizing [3H]N,N-di-o-tolylguanidine ([3H]DTG) and guinea pig brain membrane suspensions


J Med Chem 40: 4281-9 (1998)


Article DOI: 10.1021/jm970459c
BindingDB Entry DOI: 10.7270/Q2G161HQ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(HUMAN)
BDBM50061804
PNG
(CHEMBL538283 | N'-(3-Bromo-phenyl)-N-(3-ethyl-phen...)
Show SMILES CCc1cccc(c1)N(C)C(N)=Nc1cccc(Br)c1
Show InChI InChI=1S/C16H18BrN3/c1-3-12-6-4-9-15(10-12)20(2)16(18)19-14-8-5-7-13(17)11-14/h4-11H,3H2,1-2H3,(H2,18,19)
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n/an/a 40n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Binding assay for the sigma receptor sites is performed by utilizing [3H]N,N-di-o-tolylguanidine ([3H]DTG) and guinea pig brain membrane suspensions


J Med Chem 40: 4281-9 (1998)


Article DOI: 10.1021/jm970459c
BindingDB Entry DOI: 10.7270/Q2G161HQ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(HUMAN)
BDBM50061758
PNG
(CHEMBL545542 | N'-(2,5-Dibromo-3-ethyl-phenyl)-N-(...)
Show SMILES CCc1cccc(c1)N(C)C(N)=Nc1cc(Br)cc(CC)c1Br
Show InChI InChI=1S/C18H21Br2N3/c1-4-12-7-6-8-15(9-12)23(3)18(21)22-16-11-14(19)10-13(5-2)17(16)20/h6-11H,4-5H2,1-3H3,(H2,21,22)
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n/an/a 40n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Binding assay for the sigma receptor sites is performed by utilizing [3H]N,N-di-o-tolylguanidine ([3H]DTG) and guinea pig brain membrane suspensions


J Med Chem 40: 4281-9 (1998)


Article DOI: 10.1021/jm970459c
BindingDB Entry DOI: 10.7270/Q2G161HQ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(HUMAN)
BDBM50043950
PNG
(CHEMBL90508 | N-(2-Iodo-phenyl)-N'-naphthalen-1-yl...)
Show SMILES NC(Nc1ccccc1I)=Nc1cccc2ccccc12
Show InChI InChI=1S/C17H14IN3/c18-14-9-3-4-10-16(14)21-17(19)20-15-11-5-7-12-6-1-2-8-13(12)15/h1-11H,(H3,19,20,21)
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n/an/a 40n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane


J Med Chem 37: 260-7 (1994)


Article DOI: 10.1021/jm00028a009
BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(HUMAN)
BDBM50010739
PNG
(CHEMBL79437 | N,N'-Bis-(3-propyl-phenyl)-guanidine)
Show SMILES CCCc1cccc(NC(N)=Nc2cccc(CCC)c2)c1
Show InChI InChI=1S/C19H25N3/c1-3-7-15-9-5-11-17(13-15)21-19(20)22-18-12-6-10-16(14-18)8-4-2/h5-6,9-14H,3-4,7-8H2,1-2H3,(H3,20,21,22)
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n/an/a 42n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane


J Med Chem 37: 260-7 (1994)


Article DOI: 10.1021/jm00028a009
BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(HUMAN)
BDBM50061747
PNG
(CHEMBL542964 | N-(3-Ethyl-phenyl)-N-methyl-N'-phen...)
Show SMILES CCc1cccc(c1)N(C)C(N)=Nc1ccccc1
Show InChI InChI=1S/C16H19N3/c1-3-13-8-7-11-15(12-13)19(2)16(17)18-14-9-5-4-6-10-14/h4-12H,3H2,1-2H3,(H2,17,18)
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n/an/a 43n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Binding assay for the sigma receptor sites is performed by utilizing [3H]N,N-di-o-tolylguanidine ([3H]DTG) and guinea pig brain membrane suspensions


J Med Chem 40: 4281-9 (1998)


Article DOI: 10.1021/jm970459c
BindingDB Entry DOI: 10.7270/Q2G161HQ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(HUMAN)
BDBM50010791
PNG
(CHEMBL309603 | N,N'-Di-m-tolyl-guanidine)
Show SMILES Cc1cccc(NC(N)=Nc2cccc(C)c2)c1
Show InChI InChI=1S/C15H17N3/c1-11-5-3-7-13(9-11)17-15(16)18-14-8-4-6-12(2)10-14/h3-10H,1-2H3,(H3,16,17,18)
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n/an/a 43n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane


J Med Chem 37: 260-7 (1994)


Article DOI: 10.1021/jm00028a009
BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(HUMAN)
BDBM50061799
PNG
(CHEMBL555091 | N'-(3-Chloro-phenyl)-N-(3-ethyl-phe...)
Show SMILES CCc1cccc(c1)N(C)C(N)=Nc1cccc(Cl)c1
Show InChI InChI=1S/C16H18ClN3/c1-3-12-6-4-9-15(10-12)20(2)16(18)19-14-8-5-7-13(17)11-14/h4-11H,3H2,1-2H3,(H2,18,19)
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n/an/a 44n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Binding assay for the sigma receptor sites is performed by utilizing [3H]N,N-di-o-tolylguanidine ([3H]DTG) and guinea pig brain membrane suspensions


J Med Chem 40: 4281-9 (1998)


Article DOI: 10.1021/jm970459c
BindingDB Entry DOI: 10.7270/Q2G161HQ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(HUMAN)
BDBM50061791
PNG
(CHEMBL545544 | N'-(2-Chloro-3-ethyl-5-methyl-pheny...)
Show SMILES CCc1cccc(c1)N(C)C(N)=Nc1cc(C)cc(CC)c1Cl
Show InChI InChI=1S/C19H24ClN3/c1-5-14-8-7-9-16(12-14)23(4)19(21)22-17-11-13(3)10-15(6-2)18(17)20/h7-12H,5-6H2,1-4H3,(H2,21,22)
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n/an/a 45n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Binding assay for the sigma receptor sites is performed by utilizing [3H]N,N-di-o-tolylguanidine ([3H]DTG) and guinea pig brain membrane suspensions


J Med Chem 40: 4281-9 (1998)


Article DOI: 10.1021/jm970459c
BindingDB Entry DOI: 10.7270/Q2G161HQ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(HUMAN)
BDBM50061797
PNG
(CHEMBL539549 | N'-(4-Chloro-phenyl)-N-(3-ethyl-phe...)
Show SMILES CCc1cccc(c1)N(C)C(N)=Nc1ccc(Cl)cc1
Show InChI InChI=1S/C16H18ClN3/c1-3-12-5-4-6-15(11-12)20(2)16(18)19-14-9-7-13(17)8-10-14/h4-11H,3H2,1-2H3,(H2,18,19)
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n/an/a 46n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Binding assay for the sigma receptor sites is performed by utilizing [3H]N,N-di-o-tolylguanidine ([3H]DTG) and guinea pig brain membrane suspensions


J Med Chem 40: 4281-9 (1998)


Article DOI: 10.1021/jm970459c
BindingDB Entry DOI: 10.7270/Q2G161HQ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(HUMAN)
BDBM50043968
PNG
(CHEMBL91713 | N-(3-Ethyl-phenyl)-N'-naphthalen-1-y...)
Show SMILES CCc1cccc(NC(N)=Nc2cccc3ccccc23)c1
Show InChI InChI=1S/C19H19N3/c1-2-14-7-5-10-16(13-14)21-19(20)22-18-12-6-9-15-8-3-4-11-17(15)18/h3-13H,2H2,1H3,(H3,20,21,22)
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n/an/a 54n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane


J Med Chem 37: 260-7 (1994)


Article DOI: 10.1021/jm00028a009
BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(HUMAN)
BDBM50010806
PNG
(CHEMBL78306 | N,N'-Bis-(5,6,7,8-tetrahydro-naphtha...)
Show SMILES NC(Nc1cccc2CCCCc12)=Nc1cccc2CCCCc12
Show InChI InChI=1S/C21H25N3/c22-21(23-19-13-5-9-15-7-1-3-11-17(15)19)24-20-14-6-10-16-8-2-4-12-18(16)20/h5-6,9-10,13-14H,1-4,7-8,11-12H2,(H3,22,23,24)
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n/an/a 59n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane


J Med Chem 37: 260-7 (1994)


Article DOI: 10.1021/jm00028a009
BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(HUMAN)
BDBM50043963
PNG
(CHEMBL88660 | N-(3-Ethyl-phenyl)-4-phenyl-piperidi...)
Show SMILES CCc1cccc(c1)N=C(N)N1CCC(CC1)c1ccccc1
Show InChI InChI=1S/C20H25N3/c1-2-16-7-6-10-19(15-16)22-20(21)23-13-11-18(12-14-23)17-8-4-3-5-9-17/h3-10,15,18H,2,11-14H2,1H3,(H2,21,22)
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n/an/a 60n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane


J Med Chem 37: 260-7 (1994)


Article DOI: 10.1021/jm00028a009
BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(HUMAN)
BDBM50061782
PNG
(CHEMBL553167 | N-(2,5-Dichloro-phenyl)-N'-(3-ethyl...)
Show SMILES CCc1cccc(c1)N=C(N)N(C)c1cc(Cl)ccc1Cl
Show InChI InChI=1S/C16H17Cl2N3/c1-3-11-5-4-6-13(9-11)20-16(19)21(2)15-10-12(17)7-8-14(15)18/h4-10H,3H2,1-2H3,(H2,19,20)
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n/an/a 64n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Binding assay for the sigma receptor sites is performed by utilizing [3H]N,N-di-o-tolylguanidine ([3H]DTG) and guinea pig brain membrane suspensions


J Med Chem 40: 4281-9 (1998)


Article DOI: 10.1021/jm970459c
BindingDB Entry DOI: 10.7270/Q2G161HQ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(HUMAN)
BDBM50061784
PNG
(CHEMBL542959 | N-(3,5-Dichloro-phenyl)-N'-(3-ethyl...)
Show SMILES CCc1cccc(NC(N)=Nc2cc(Cl)cc(Cl)c2)c1
Show InChI InChI=1S/C15H15Cl2N3/c1-2-10-4-3-5-13(6-10)19-15(18)20-14-8-11(16)7-12(17)9-14/h3-9H,2H2,1H3,(H3,18,19,20)
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n/an/a 70n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Binding assay for the sigma receptor sites is performed by utilizing [3H]N,N-di-o-tolylguanidine ([3H]DTG) and guinea pig brain membrane suspensions


J Med Chem 40: 4281-9 (1998)


Article DOI: 10.1021/jm970459c
BindingDB Entry DOI: 10.7270/Q2G161HQ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(HUMAN)
BDBM50061760
PNG
(CHEMBL554618 | N'-(2-Chloro-phenyl)-N-(3-ethyl-phe...)
Show SMILES CCc1cccc(c1)N(C)C(N)=Nc1ccccc1Cl
Show InChI InChI=1S/C16H18ClN3/c1-3-12-7-6-8-13(11-12)20(2)16(18)19-15-10-5-4-9-14(15)17/h4-11H,3H2,1-2H3,(H2,18,19)
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n/an/a 72n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Binding assay for the sigma receptor sites is performed by utilizing [3H]N,N-di-o-tolylguanidine ([3H]DTG) and guinea pig brain membrane suspensions


J Med Chem 40: 4281-9 (1998)


Article DOI: 10.1021/jm970459c
BindingDB Entry DOI: 10.7270/Q2G161HQ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(HUMAN)
BDBM50043955
PNG
(CHEMBL88932 | N-Naphthalen-1-yl-N'-m-tolyl-guanidi...)
Show SMILES Cc1cccc(NC(N)=Nc2cccc3ccccc23)c1
Show InChI InChI=1S/C18H17N3/c1-13-6-4-9-15(12-13)20-18(19)21-17-11-5-8-14-7-2-3-10-16(14)17/h2-12H,1H3,(H3,19,20,21)
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n/an/a 75n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane


J Med Chem 37: 260-7 (1994)


Article DOI: 10.1021/jm00028a009
BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(HUMAN)
BDBM50061803
PNG
(CHEMBL540831 | N'-(3-Ethyl-2-fluoro-5-trifluoromet...)
Show SMILES CCc1cccc(c1)N(C)C(N)=Nc1cc(cc(CC)c1F)C(F)(F)F
Show InChI InChI=1S/C19H21F4N3/c1-4-12-7-6-8-15(9-12)26(3)18(24)25-16-11-14(19(21,22)23)10-13(5-2)17(16)20/h6-11H,4-5H2,1-3H3,(H2,24,25)
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n/an/a 79n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Binding assay for the sigma receptor sites is performed by utilizing [3H]N,N-di-o-tolylguanidine ([3H]DTG) and guinea pig brain membrane suspensions


J Med Chem 40: 4281-9 (1998)


Article DOI: 10.1021/jm970459c
BindingDB Entry DOI: 10.7270/Q2G161HQ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(HUMAN)
BDBM50043977
PNG
(CHEMBL543434 | CHEMBL91628 | N,N'-Bis-(3-ethyl-phe...)
Show SMILES CCc1cccc(c1)N=C(N)N(C)c1cccc(CC)c1
Show InChI InChI=1S/C18H23N3/c1-4-14-8-6-10-16(12-14)20-18(19)21(3)17-11-7-9-15(5-2)13-17/h6-13H,4-5H2,1-3H3,(H2,19,20)
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n/an/a 82n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Binding assay for the sigma receptor sites is performed by utilizing [3H]N,N-di-o-tolylguanidine ([3H]DTG) and guinea pig brain membrane suspensions


J Med Chem 40: 4281-9 (1998)


Article DOI: 10.1021/jm970459c
BindingDB Entry DOI: 10.7270/Q2G161HQ
More data for this
Ligand-Target Pair
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