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Compile Data Set for Download or QSAR

Found 132 hits from Cancer Therapeutics CRC Pty Ltd   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM155552
PNG
(US9012461, 28)
Show SMILES CN1CCc2cc(Nc3ncc(c(CCc4ccccc4CC(N)=O)n3)C(F)(F)F)ccc2C1
Show InChI InChI=1S/C25H26F3N5O/c1-33-11-10-18-12-20(8-6-19(18)15-33)31-24-30-14-21(25(26,27)28)22(32-24)9-7-16-4-2-3-5-17(16)13-23(29)34/h2-6,8,12,14H,7,9-11,13,15H2,1H3,(H2,29,34)(H,30,31,32)
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n/an/a 0.300n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
A biotin labeled peptide is used as substrate (amino acid sequence: Biotin-Glu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2)1S...


US Patent US9012461 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36K7
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM155547
PNG
(US9012461, 23)
Show SMILES CC(=O)N1CCC(CC1)c1ccc(Nc2ncc(c(CCc3ccccc3CC(N)=O)n2)C(F)(F)F)cc1
Show InChI InChI=1S/C28H30F3N5O2/c1-18(37)36-14-12-21(13-15-36)20-6-9-23(10-7-20)34-27-33-17-24(28(29,30)31)25(35-27)11-8-19-4-2-3-5-22(19)16-26(32)38/h2-7,9-10,17,21H,8,11-16H2,1H3,(H2,32,38)(H,33,34,35)
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n/an/a 0.390n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
A biotin labeled peptide is used as substrate (amino acid sequence: Biotin-Glu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2)1S...


US Patent US9012461 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36K7
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM155537
PNG
(US9012461, 13)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(Nc2ncc(c(CCc3ccccc3CC(N)=O)n2)C(F)(F)F)cc1
Show InChI InChI=1S/C27H29F3N6O2/c1-18(37)35-12-14-36(15-13-35)22-9-7-21(8-10-22)33-26-32-17-23(27(28,29)30)24(34-26)11-6-19-4-2-3-5-20(19)16-25(31)38/h2-5,7-10,17H,6,11-16H2,1H3,(H2,31,38)(H,32,33,34)
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n/an/a 0.600n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
A biotin labeled peptide is used as substrate (amino acid sequence: Biotin-Glu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2)1S...


US Patent US9012461 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36K7
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM155548
PNG
(US9012461, 24)
Show SMILES CC(=O)C1CCN(CC1)c1ccc(Nc2ncc(c(CCc3ccccc3CC(N)=O)n2)C(F)(F)F)cc1
Show InChI InChI=1S/C28H30F3N5O2/c1-18(37)19-12-14-36(15-13-19)23-9-7-22(8-10-23)34-27-33-17-24(28(29,30)31)25(35-27)11-6-20-4-2-3-5-21(20)16-26(32)38/h2-5,7-10,17,19H,6,11-16H2,1H3,(H2,32,38)(H,33,34,35)
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n/an/a 0.770n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
A biotin labeled peptide is used as substrate (amino acid sequence: Biotin-Glu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2)1S...


US Patent US9012461 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36K7
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM155544
PNG
(US9012461, 20)
Show SMILES NC1CCN(CC1)c1ccc(Nc2ncc(c(CCc3ccccc3CC(N)=O)n2)C(F)(F)F)cc1
Show InChI InChI=1S/C26H29F3N6O/c27-26(28,29)22-16-32-25(33-20-6-8-21(9-7-20)35-13-11-19(30)12-14-35)34-23(22)10-5-17-3-1-2-4-18(17)15-24(31)36/h1-4,6-9,16,19H,5,10-15,30H2,(H2,31,36)(H,32,33,34)
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n/an/a 0.810n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
A biotin labeled peptide is used as substrate (amino acid sequence: Biotin-Glu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2)1S...


US Patent US9012461 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36K7
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM155527
PNG
(US9012461, 3)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc(c(CCc3ccccc3CC(N)=O)n2)C(F)(F)F)cc1
Show InChI InChI=1S/C26H29F3N6O/c1-34-12-14-35(15-13-34)21-9-7-20(8-10-21)32-25-31-17-22(26(27,28)29)23(33-25)11-6-18-4-2-3-5-19(18)16-24(30)36/h2-5,7-10,17H,6,11-16H2,1H3,(H2,30,36)(H,31,32,33)
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n/an/a 1.10n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A biotin labeled peptide is used as substrate (amino acid sequ...


US Patent US9012461 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36K7
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM155528
PNG
(US9012461, 4)
Show SMILES NC(=O)Cc1ccccc1CCc1nc(Nc2ccc(cc2)C2CCCNC2)ncc1C(F)(F)F
Show InChI InChI=1S/C26H28F3N5O/c27-26(28,29)22-16-32-25(33-21-10-7-18(8-11-21)20-6-3-13-31-15-20)34-23(22)12-9-17-4-1-2-5-19(17)14-24(30)35/h1-2,4-5,7-8,10-11,16,20,31H,3,6,9,12-15H2,(H2,30,35)(H,32,33,34)
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n/an/a 1.5n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
A biotin labeled peptide is used as substrate (amino acid sequence: Biotin-Glu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2)1S...


US Patent US9012461 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36K7
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM155527
PNG
(US9012461, 3)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc(c(CCc3ccccc3CC(N)=O)n2)C(F)(F)F)cc1
Show InChI InChI=1S/C26H29F3N6O/c1-34-12-14-35(15-13-34)21-9-7-20(8-10-21)32-25-31-17-22(26(27,28)29)23(33-25)11-6-18-4-2-3-5-19(18)16-24(30)36/h2-5,7-10,17H,6,11-16H2,1H3,(H2,30,36)(H,31,32,33)
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n/an/a 1.90n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
A biotin labeled peptide is used as substrate (amino acid sequence: Biotin-Glu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2)1S...


US Patent US9012461 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36K7
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM155540
PNG
(US9012461, 16)
Show SMILES CN1CCC(CC1)c1ccc(Nc2ncc(c(CCc3ccccc3CC(N)=O)n2)C(F)(F)F)cc1
Show InChI InChI=1S/C27H30F3N5O/c1-35-14-12-20(13-15-35)19-6-9-22(10-7-19)33-26-32-17-23(27(28,29)30)24(34-26)11-8-18-4-2-3-5-21(18)16-25(31)36/h2-7,9-10,17,20H,8,11-16H2,1H3,(H2,31,36)(H,32,33,34)
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n/an/a 2n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
A biotin labeled peptide is used as substrate (amino acid sequence: Biotin-Glu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2)1S...


US Patent US9012461 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36K7
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM155525
PNG
(US9012461, 1)
Show SMILES NC(=O)Cc1ccccc1CCc1nc(Nc2ccc(cc2)N2CCNCC2)ncc1C(F)(F)F
Show InChI InChI=1S/C25H27F3N6O/c26-25(27,28)21-16-31-24(32-19-6-8-20(9-7-19)34-13-11-30-12-14-34)33-22(21)10-5-17-3-1-2-4-18(17)15-23(29)35/h1-4,6-9,16,30H,5,10-15H2,(H2,29,35)(H,31,32,33)
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n/an/a 2.10n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
A biotin labeled peptide is used as substrate (amino acid sequence: Biotin-Glu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2)1S...


US Patent US9012461 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36K7
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM155560
PNG
(US9012461, 36)
Show SMILES CN1CCN(Cc2ccc(Nc3ncc(c(CCc4ccccc4CC(N)=O)n3)C(F)(F)F)cc2)CC1
Show InChI InChI=1S/C27H31F3N6O/c1-35-12-14-36(15-13-35)18-19-6-9-22(10-7-19)33-26-32-17-23(27(28,29)30)24(34-26)11-8-20-4-2-3-5-21(20)16-25(31)37/h2-7,9-10,17H,8,11-16,18H2,1H3,(H2,31,37)(H,32,33,34)
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n/an/a 2.30n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
A biotin labeled peptide is used as substrate (amino acid sequence: Biotin-Glu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2)1S...


US Patent US9012461 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36K7
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM155529
PNG
(US9012461, 5 | US9012461, 7)
Show SMILES CN1CCCC(C1)c1ccc(Nc2ncc(c(CCc3ccccc3CC(N)=O)n2)C(F)(F)F)cc1
Show InChI InChI=1S/C27H30F3N5O/c1-35-14-4-7-21(17-35)19-8-11-22(12-9-19)33-26-32-16-23(27(28,29)30)24(34-26)13-10-18-5-2-3-6-20(18)15-25(31)36/h2-3,5-6,8-9,11-12,16,21H,4,7,10,13-15,17H2,1H3,(H2,31,36)(H,32,33,34)
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n/an/a 2.40n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
A biotin labeled peptide is used as substrate (amino acid sequence: Biotin-Glu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2)1S...


US Patent US9012461 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36K7
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM155545
PNG
(US9012461, 21)
Show SMILES NC(=O)Cc1ccccc1CCc1nc(Nc2ccc3CNCCc3c2)ncc1C(F)(F)F
Show InChI InChI=1S/C24H24F3N5O/c25-24(26,27)20-14-30-23(31-19-7-5-18-13-29-10-9-17(18)11-19)32-21(20)8-6-15-3-1-2-4-16(15)12-22(28)33/h1-5,7,11,14,29H,6,8-10,12-13H2,(H2,28,33)(H,30,31,32)
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n/an/a 2.40n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
A biotin labeled peptide is used as substrate (amino acid sequence: Biotin-Glu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2)1S...


US Patent US9012461 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36K7
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM155526
PNG
(US9012461, 2)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc(c(CCc3cccc(c3)C(N)=O)n2)C(F)(F)F)cc1
Show InChI InChI=1S/C25H27F3N6O/c1-33-11-13-34(14-12-33)20-8-6-19(7-9-20)31-24-30-16-21(25(26,27)28)22(32-24)10-5-17-3-2-4-18(15-17)23(29)35/h2-4,6-9,15-16H,5,10-14H2,1H3,(H2,29,35)(H,30,31,32)
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n/an/a 2.5n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
A biotin labeled peptide is used as substrate (amino acid sequence: Biotin-Glu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2)1S...


US Patent US9012461 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36K7
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM155535
PNG
(US9012461, 11)
Show SMILES NC(=O)Cc1ccccc1CCc1nc(Nc2ccc(cc2)C2CCNCC2)ncc1C(F)(F)F
Show InChI InChI=1S/C26H28F3N5O/c27-26(28,29)22-16-32-25(33-21-8-5-18(6-9-21)19-11-13-31-14-12-19)34-23(22)10-7-17-3-1-2-4-20(17)15-24(30)35/h1-6,8-9,16,19,31H,7,10-15H2,(H2,30,35)(H,32,33,34)
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n/an/a 2.5n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A biotin labeled peptide is used as substrate (amino acid sequ...


US Patent US9012461 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36K7
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM155533
PNG
(US9012461, 9)
Show SMILES CN1CCCCC1c1ccc(Nc2ncc(c(CCc3ccccc3CC(N)=O)n2)C(F)(F)F)cc1
Show InChI InChI=1S/C27H30F3N5O/c1-35-15-5-4-8-24(35)19-9-12-21(13-10-19)33-26-32-17-22(27(28,29)30)23(34-26)14-11-18-6-2-3-7-20(18)16-25(31)36/h2-3,6-7,9-10,12-13,17,24H,4-5,8,11,14-16H2,1H3,(H2,31,36)(H,32,33,34)
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n/an/a 2.5n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A biotin labeled peptide is used as substrate (amino acid sequ...


US Patent US9012461 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36K7
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM155546
PNG
(US9012461, 22)
Show SMILES NC(=O)Cc1ccccc1CCc1nc(Nc2ccc(cc2)C2CNCCO2)ncc1C(F)(F)F
Show InChI InChI=1S/C25H26F3N5O2/c26-25(27,28)20-14-31-24(32-19-8-5-17(6-9-19)22-15-30-11-12-35-22)33-21(20)10-7-16-3-1-2-4-18(16)13-23(29)34/h1-6,8-9,14,22,30H,7,10-13,15H2,(H2,29,34)(H,31,32,33)
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n/an/a 2.80n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
A biotin labeled peptide is used as substrate (amino acid sequence: Biotin-Glu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2)1S...


US Patent US9012461 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36K7
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM155534
PNG
(US9012461, 10)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2ncc(c(CCc3ccccc3CC(N)=O)n2)C(F)(F)F)cc1
Show InChI InChI=1S/C27H31F3N6O/c1-2-35-13-15-36(16-14-35)22-10-8-21(9-11-22)33-26-32-18-23(27(28,29)30)24(34-26)12-7-19-5-3-4-6-20(19)17-25(31)37/h3-6,8-11,18H,2,7,12-17H2,1H3,(H2,31,37)(H,32,33,34)
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n/an/a 2.90n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
A biotin labeled peptide is used as substrate (amino acid sequence: Biotin-Glu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2)1S...


US Patent US9012461 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36K7
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM155549
PNG
(US9012461, 25)
Show SMILES NC(=O)Cc1ccccc1CCc1nc(Nc2ccc(CN3CCNCC3)cc2)ncc1C(F)(F)F
Show InChI InChI=1S/C26H29F3N6O/c27-26(28,29)22-16-32-25(33-21-8-5-18(6-9-21)17-35-13-11-31-12-14-35)34-23(22)10-7-19-3-1-2-4-20(19)15-24(30)36/h1-6,8-9,16,31H,7,10-15,17H2,(H2,30,36)(H,32,33,34)
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n/an/a 3n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
A biotin labeled peptide is used as substrate (amino acid sequence: Biotin-Glu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2)1S...


US Patent US9012461 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36K7
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM155535
PNG
(US9012461, 11)
Show SMILES NC(=O)Cc1ccccc1CCc1nc(Nc2ccc(cc2)C2CCNCC2)ncc1C(F)(F)F
Show InChI InChI=1S/C26H28F3N5O/c27-26(28,29)22-16-32-25(33-21-8-5-18(6-9-21)19-11-13-31-14-12-19)34-23(22)10-7-17-3-1-2-4-20(17)15-24(30)35/h1-6,8-9,16,19,31H,7,10-15H2,(H2,30,35)(H,32,33,34)
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n/an/a 3n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
A biotin labeled peptide is used as substrate (amino acid sequence: Biotin-Glu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2)1S...


US Patent US9012461 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36K7
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM155541
PNG
(US9012461, 17)
Show SMILES CN1CCN(CC1)c1cccc(Nc2ncc(c(CCc3ccccc3CC(N)=O)n2)C(F)(F)F)c1
Show InChI InChI=1S/C26H29F3N6O/c1-34-11-13-35(14-12-34)21-8-4-7-20(16-21)32-25-31-17-22(26(27,28)29)23(33-25)10-9-18-5-2-3-6-19(18)15-24(30)36/h2-8,16-17H,9-15H2,1H3,(H2,30,36)(H,31,32,33)
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n/an/a 3.40n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
A biotin labeled peptide is used as substrate (amino acid sequence: Biotin-Glu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2)1S...


US Patent US9012461 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36K7
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM155556
PNG
(US9012461, 32)
Show SMILES NC(=O)Cc1cccnc1CCc1nc(Nc2ccc(cc2)C2CCNCC2)ncc1C(F)(F)F
Show InChI InChI=1S/C25H27F3N6O/c26-25(27,28)20-15-32-24(33-19-5-3-16(4-6-19)17-9-12-30-13-10-17)34-22(20)8-7-21-18(14-23(29)35)2-1-11-31-21/h1-6,11,15,17,30H,7-10,12-14H2,(H2,29,35)(H,32,33,34)
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n/an/a 3.5n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
A biotin labeled peptide is used as substrate (amino acid sequence: Biotin-Glu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2)1S...


US Patent US9012461 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36K7
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM155555
PNG
(US9012461, 31)
Show SMILES CCN1CCC(CC1)c1ccc(Nc2ncc(c(CCc3ccccc3CC(N)=O)n2)C(F)(F)F)cc1
Show InChI InChI=1S/C28H32F3N5O/c1-2-36-15-13-21(14-16-36)20-7-10-23(11-8-20)34-27-33-18-24(28(29,30)31)25(35-27)12-9-19-5-3-4-6-22(19)17-26(32)37/h3-8,10-11,18,21H,2,9,12-17H2,1H3,(H2,32,37)(H,33,34,35)
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n/an/a 3.60n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
A biotin labeled peptide is used as substrate (amino acid sequence: Biotin-Glu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2)1S...


US Patent US9012461 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36K7
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM155548
PNG
(US9012461, 24)
Show SMILES CC(=O)C1CCN(CC1)c1ccc(Nc2ncc(c(CCc3ccccc3CC(N)=O)n2)C(F)(F)F)cc1
Show InChI InChI=1S/C28H30F3N5O2/c1-18(37)19-12-14-36(15-13-19)23-9-7-22(8-10-23)34-27-33-17-24(28(29,30)31)25(35-27)11-6-20-4-2-3-5-21(20)16-26(32)38/h2-5,7-10,17,19H,6,11-16H2,1H3,(H2,32,38)(H,33,34,35)
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n/an/a 3.90n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A biotin labeled peptide is used as substrate (amino acid sequ...


US Patent US9012461 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36K7
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM155528
PNG
(US9012461, 4)
Show SMILES NC(=O)Cc1ccccc1CCc1nc(Nc2ccc(cc2)C2CCCNC2)ncc1C(F)(F)F
Show InChI InChI=1S/C26H28F3N5O/c27-26(28,29)22-16-32-25(33-21-10-7-18(8-11-21)20-6-3-13-31-15-20)34-23(22)12-9-17-4-1-2-5-19(17)14-24(30)35/h1-2,4-5,7-8,10-11,16,20,31H,3,6,9,12-15H2,(H2,30,35)(H,32,33,34)
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n/an/a 4n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A biotin labeled peptide is used as substrate (amino acid sequ...


US Patent US9012461 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36K7
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM155534
PNG
(US9012461, 10)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2ncc(c(CCc3ccccc3CC(N)=O)n2)C(F)(F)F)cc1
Show InChI InChI=1S/C27H31F3N6O/c1-2-35-13-15-36(16-14-35)22-10-8-21(9-11-22)33-26-32-18-23(27(28,29)30)24(34-26)12-7-19-5-3-4-6-20(19)17-25(31)37/h3-6,8-11,18H,2,7,12-17H2,1H3,(H2,31,37)(H,32,33,34)
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n/an/a 4n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A biotin labeled peptide is used as substrate (amino acid sequ...


US Patent US9012461 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36K7
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM155530
PNG
(US9012461, 6)
Show SMILES CN1CCN(CC1)c1cccc(Nc2ncc(c(CCc3cccc(c3)C(N)=O)n2)C(F)(F)F)c1
Show InChI InChI=1S/C25H27F3N6O/c1-33-10-12-34(13-11-33)20-7-3-6-19(15-20)31-24-30-16-21(25(26,27)28)22(32-24)9-8-17-4-2-5-18(14-17)23(29)35/h2-7,14-16H,8-13H2,1H3,(H2,29,35)(H,30,31,32)
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n/an/a 4.20n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
A biotin labeled peptide is used as substrate (amino acid sequence: Biotin-Glu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2)1S...


US Patent US9012461 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36K7
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM155532
PNG
(US9012461, 8)
Show SMILES NC(=O)Cc1ccccc1CCc1nc(Nc2ccc(cc2)C2CCCCN2)ncc1C(F)(F)F
Show InChI InChI=1S/C26H28F3N5O/c27-26(28,29)21-16-32-25(33-20-11-8-18(9-12-20)22-7-3-4-14-31-22)34-23(21)13-10-17-5-1-2-6-19(17)15-24(30)35/h1-2,5-6,8-9,11-12,16,22,31H,3-4,7,10,13-15H2,(H2,30,35)(H,32,33,34)
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n/an/a 4.80n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A biotin labeled peptide is used as substrate (amino acid sequ...


US Patent US9012461 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36K7
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM155544
PNG
(US9012461, 20)
Show SMILES NC1CCN(CC1)c1ccc(Nc2ncc(c(CCc3ccccc3CC(N)=O)n2)C(F)(F)F)cc1
Show InChI InChI=1S/C26H29F3N6O/c27-26(28,29)22-16-32-25(33-20-6-8-21(9-7-20)35-13-11-19(30)12-14-35)34-23(22)10-5-17-3-1-2-4-18(17)15-24(31)36/h1-4,6-9,16,19H,5,10-15,30H2,(H2,31,36)(H,32,33,34)
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n/an/a 5n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A biotin labeled peptide is used as substrate (amino acid sequ...


US Patent US9012461 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36K7
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM155556
PNG
(US9012461, 32)
Show SMILES NC(=O)Cc1cccnc1CCc1nc(Nc2ccc(cc2)C2CCNCC2)ncc1C(F)(F)F
Show InChI InChI=1S/C25H27F3N6O/c26-25(27,28)20-15-32-24(33-19-5-3-16(4-6-19)17-9-12-30-13-10-17)34-22(20)8-7-21-18(14-23(29)35)2-1-11-31-21/h1-6,11,15,17,30H,7-10,12-14H2,(H2,29,35)(H,32,33,34)
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n/an/a 5.10n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A biotin labeled peptide is used as substrate (amino acid sequ...


US Patent US9012461 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36K7
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM155558
PNG
(US9012461, 34)
Show SMILES CN1CCC(CC1)c1ccc(Nc2ncc(c(CCc3cc(ccn3)C(N)=O)n2)C(F)(F)F)cc1
Show InChI InChI=1S/C25H27F3N6O/c1-34-12-9-17(10-13-34)16-2-4-19(5-3-16)32-24-31-15-21(25(26,27)28)22(33-24)7-6-20-14-18(23(29)35)8-11-30-20/h2-5,8,11,14-15,17H,6-7,9-10,12-13H2,1H3,(H2,29,35)(H,31,32,33)
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n/an/a 5.70n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
A biotin labeled peptide is used as substrate (amino acid sequence: Biotin-Glu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2)1S...


US Patent US9012461 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36K7
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM155532
PNG
(US9012461, 8)
Show SMILES NC(=O)Cc1ccccc1CCc1nc(Nc2ccc(cc2)C2CCCCN2)ncc1C(F)(F)F
Show InChI InChI=1S/C26H28F3N5O/c27-26(28,29)21-16-32-25(33-20-11-8-18(9-12-20)22-7-3-4-14-31-22)34-23(21)13-10-17-5-1-2-6-19(17)15-24(30)35/h1-2,5-6,8-9,11-12,16,22,31H,3-4,7,10,13-15H2,(H2,30,35)(H,32,33,34)
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n/an/a 6.10n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
A biotin labeled peptide is used as substrate (amino acid sequence: Biotin-Glu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2)1S...


US Patent US9012461 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36K7
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM155557
PNG
(US9012461, 33)
Show SMILES CN1CCC(CC1)c1ccc(Nc2ncc(c(CCc3ncccc3CC(N)=O)n2)C(F)(F)F)cc1
Show InChI InChI=1S/C26H29F3N6O/c1-35-13-10-18(11-14-35)17-4-6-20(7-5-17)33-25-32-16-21(26(27,28)29)23(34-25)9-8-22-19(15-24(30)36)3-2-12-31-22/h2-7,12,16,18H,8-11,13-15H2,1H3,(H2,30,36)(H,32,33,34)
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n/an/a 6.20n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
A biotin labeled peptide is used as substrate (amino acid sequence: Biotin-Glu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2)1S...


US Patent US9012461 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36K7
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM155536
PNG
(US9012461, 12)
Show SMILES CC(C(N)=O)c1ccccc1CCc1nc(Nc2ccc(cc2)C2CCNCC2)ncc1C(F)(F)F
Show InChI InChI=1S/C27H30F3N5O/c1-17(25(31)36)22-5-3-2-4-20(22)8-11-24-23(27(28,29)30)16-33-26(35-24)34-21-9-6-18(7-10-21)19-12-14-32-15-13-19/h2-7,9-10,16-17,19,32H,8,11-15H2,1H3,(H2,31,36)(H,33,34,35)
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n/an/a 6.30n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
A biotin labeled peptide is used as substrate (amino acid sequence: Biotin-Glu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2)1S...


US Patent US9012461 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36K7
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM155533
PNG
(US9012461, 9)
Show SMILES CN1CCCCC1c1ccc(Nc2ncc(c(CCc3ccccc3CC(N)=O)n2)C(F)(F)F)cc1
Show InChI InChI=1S/C27H30F3N5O/c1-35-15-5-4-8-24(35)19-9-12-21(13-10-19)33-26-32-17-22(27(28,29)30)23(34-26)14-11-18-6-2-3-7-20(18)16-25(31)36/h2-3,6-7,9-10,12-13,17,24H,4-5,8,11,14-16H2,1H3,(H2,31,36)(H,32,33,34)
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n/an/a 7n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
A biotin labeled peptide is used as substrate (amino acid sequence: Biotin-Glu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2)1S...


US Patent US9012461 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36K7
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM155554
PNG
(US9012461, 30)
Show SMILES CN1CCC(CC1)c1ccc(Nc2ncc(c(CCc3ncncc3CC(N)=O)n2)C(F)(F)F)cc1
Show InChI InChI=1S/C25H28F3N7O/c1-35-10-8-17(9-11-35)16-2-4-19(5-3-16)33-24-31-14-20(25(26,27)28)22(34-24)7-6-21-18(12-23(29)36)13-30-15-32-21/h2-5,13-15,17H,6-12H2,1H3,(H2,29,36)(H,31,33,34)
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n/an/a 7n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A biotin labeled peptide is used as substrate (amino acid sequ...


US Patent US9012461 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36K7
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM155551
PNG
(US9012461, 27)
Show SMILES CN1CCC(CC1)c1ccc(Nc2ncc(c(CCc3nccnc3CC(N)=O)n2)C(F)(F)F)cc1
Show InChI InChI=1S/C25H28F3N7O/c1-35-12-8-17(9-13-35)16-2-4-18(5-3-16)33-24-32-15-19(25(26,27)28)20(34-24)6-7-21-22(14-23(29)36)31-11-10-30-21/h2-5,10-11,15,17H,6-9,12-14H2,1H3,(H2,29,36)(H,32,33,34)
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n/an/a 7.20n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
A biotin labeled peptide is used as substrate (amino acid sequence: Biotin-Glu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2)1S...


US Patent US9012461 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36K7
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM155559
PNG
(US9012461, 35)
Show SMILES NC(=O)Cc1ccccc1CCc1nc(Nc2ccc(cc2)C2CCNC2)ncc1C(F)(F)F
Show InChI InChI=1S/C25H26F3N5O/c26-25(27,28)21-15-31-24(32-20-8-5-17(6-9-20)19-11-12-30-14-19)33-22(21)10-7-16-3-1-2-4-18(16)13-23(29)34/h1-6,8-9,15,19,30H,7,10-14H2,(H2,29,34)(H,31,32,33)
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n/an/a 7.70n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
A biotin labeled peptide is used as substrate (amino acid sequence: Biotin-Glu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2)1S...


US Patent US9012461 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36K7
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM155543
PNG
(US9012461, 19)
Show SMILES Cc1ccc(CCc2nc(Nc3ccc(cc3)N3CCNCC3)ncc2C(F)(F)F)cc1C(N)=O
Show InChI InChI=1S/C25H27F3N6O/c1-16-2-3-17(14-20(16)23(29)35)4-9-22-21(25(26,27)28)15-31-24(33-22)32-18-5-7-19(8-6-18)34-12-10-30-11-13-34/h2-3,5-8,14-15,30H,4,9-13H2,1H3,(H2,29,35)(H,31,32,33)
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n/an/a 7.70n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
A biotin labeled peptide is used as substrate (amino acid sequence: Biotin-Glu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2)1S...


US Patent US9012461 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36K7
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM155529
PNG
(US9012461, 5 | US9012461, 7)
Show SMILES CN1CCCC(C1)c1ccc(Nc2ncc(c(CCc3ccccc3CC(N)=O)n2)C(F)(F)F)cc1
Show InChI InChI=1S/C27H30F3N5O/c1-35-14-4-7-21(17-35)19-8-11-22(12-9-19)33-26-32-16-23(27(28,29)30)24(34-26)13-10-18-5-2-3-6-20(18)15-25(31)36/h2-3,5-6,8-9,11-12,16,21H,4,7,10,13-15,17H2,1H3,(H2,31,36)(H,32,33,34)
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n/an/a 9.60n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
A biotin labeled peptide is used as substrate (amino acid sequence: Biotin-Glu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2)1S...


US Patent US9012461 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36K7
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM155552
PNG
(US9012461, 28)
Show SMILES CN1CCc2cc(Nc3ncc(c(CCc4ccccc4CC(N)=O)n3)C(F)(F)F)ccc2C1
Show InChI InChI=1S/C25H26F3N5O/c1-33-11-10-18-12-20(8-6-19(18)15-33)31-24-30-14-21(25(26,27)28)22(32-24)9-7-16-4-2-3-5-17(16)13-23(29)34/h2-6,8,12,14H,7,9-11,13,15H2,1H3,(H2,29,34)(H,30,31,32)
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n/an/a 10n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A biotin labeled peptide is used as substrate (amino acid sequ...


US Patent US9012461 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36K7
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM155525
PNG
(US9012461, 1)
Show SMILES NC(=O)Cc1ccccc1CCc1nc(Nc2ccc(cc2)N2CCNCC2)ncc1C(F)(F)F
Show InChI InChI=1S/C25H27F3N6O/c26-25(27,28)21-16-31-24(32-19-6-8-20(9-7-19)34-13-11-30-12-14-34)33-22(21)10-5-17-3-1-2-4-18(17)15-23(29)35/h1-4,6-9,16,30H,5,10-15H2,(H2,29,35)(H,31,32,33)
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n/an/a 10n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A biotin labeled peptide is used as substrate (amino acid sequ...


US Patent US9012461 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36K7
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM155554
PNG
(US9012461, 30)
Show SMILES CN1CCC(CC1)c1ccc(Nc2ncc(c(CCc3ncncc3CC(N)=O)n2)C(F)(F)F)cc1
Show InChI InChI=1S/C25H28F3N7O/c1-35-10-8-17(9-11-35)16-2-4-19(5-3-16)33-24-31-14-20(25(26,27)28)22(34-24)7-6-21-18(12-23(29)36)13-30-15-32-21/h2-5,13-15,17H,6-12H2,1H3,(H2,29,36)(H,31,33,34)
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n/an/a 11n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
A biotin labeled peptide is used as substrate (amino acid sequence: Biotin-Glu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2)1S...


US Patent US9012461 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36K7
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM155540
PNG
(US9012461, 16)
Show SMILES CN1CCC(CC1)c1ccc(Nc2ncc(c(CCc3ccccc3CC(N)=O)n2)C(F)(F)F)cc1
Show InChI InChI=1S/C27H30F3N5O/c1-35-14-12-20(13-15-35)19-6-9-22(10-7-19)33-26-32-17-23(27(28,29)30)24(34-26)11-8-18-4-2-3-5-21(18)16-25(31)36/h2-7,9-10,17,20H,8,11-16H2,1H3,(H2,31,36)(H,32,33,34)
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n/an/a 11n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A biotin labeled peptide is used as substrate (amino acid sequ...


US Patent US9012461 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36K7
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM155553
PNG
(US9012461, 29)
Show SMILES NC(=O)Cc1cncnc1CCc1nc(Nc2ccc(cc2)C2CCNCC2)ncc1C(F)(F)F
Show InChI InChI=1S/C24H26F3N7O/c25-24(26,27)19-13-31-23(33-18-3-1-15(2-4-18)16-7-9-29-10-8-16)34-21(19)6-5-20-17(11-22(28)35)12-30-14-32-20/h1-4,12-14,16,29H,5-11H2,(H2,28,35)(H,31,33,34)
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n/an/a 11n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
A biotin labeled peptide is used as substrate (amino acid sequence: Biotin-Glu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2)1S...


US Patent US9012461 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36K7
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM155547
PNG
(US9012461, 23)
Show SMILES CC(=O)N1CCC(CC1)c1ccc(Nc2ncc(c(CCc3ccccc3CC(N)=O)n2)C(F)(F)F)cc1
Show InChI InChI=1S/C28H30F3N5O2/c1-18(37)36-14-12-21(13-15-36)20-6-9-23(10-7-20)34-27-33-17-24(28(29,30)31)25(35-27)11-8-19-4-2-3-5-22(19)16-26(32)38/h2-7,9-10,17,21H,8,11-16H2,1H3,(H2,32,38)(H,33,34,35)
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n/an/a 12n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A biotin labeled peptide is used as substrate (amino acid sequ...


US Patent US9012461 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36K7
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM155555
PNG
(US9012461, 31)
Show SMILES CCN1CCC(CC1)c1ccc(Nc2ncc(c(CCc3ccccc3CC(N)=O)n2)C(F)(F)F)cc1
Show InChI InChI=1S/C28H32F3N5O/c1-2-36-15-13-21(14-16-36)20-7-10-23(11-8-20)34-27-33-18-24(28(29,30)31)25(35-27)12-9-19-5-3-4-6-22(19)17-26(32)37/h3-8,10-11,18,21H,2,9,12-17H2,1H3,(H2,32,37)(H,33,34,35)
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n/an/a 12n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A biotin labeled peptide is used as substrate (amino acid sequ...


US Patent US9012461 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36K7
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM155536
PNG
(US9012461, 12)
Show SMILES CC(C(N)=O)c1ccccc1CCc1nc(Nc2ccc(cc2)C2CCNCC2)ncc1C(F)(F)F
Show InChI InChI=1S/C27H30F3N5O/c1-17(25(31)36)22-5-3-2-4-20(22)8-11-24-23(27(28,29)30)16-33-26(35-24)34-21-9-6-18(7-10-21)19-12-14-32-15-13-19/h2-7,9-10,16-17,19,32H,8,11-15H2,1H3,(H2,31,36)(H,33,34,35)
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n/an/a 12n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A biotin labeled peptide is used as substrate (amino acid sequ...


US Patent US9012461 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36K7
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM155529
PNG
(US9012461, 5 | US9012461, 7)
Show SMILES CN1CCCC(C1)c1ccc(Nc2ncc(c(CCc3ccccc3CC(N)=O)n2)C(F)(F)F)cc1
Show InChI InChI=1S/C27H30F3N5O/c1-35-14-4-7-21(17-35)19-8-11-22(12-9-19)33-26-32-16-23(27(28,29)30)24(34-26)13-10-18-5-2-3-6-20(18)15-25(31)36/h2-3,5-6,8-9,11-12,16,21H,4,7,10,13-15,17H2,1H3,(H2,31,36)(H,32,33,34)
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n/an/a 12n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
Compounds of the invention may be tested for in vitro activity in the following assay: A biotin labeled peptide is used as substrate (amino acid sequ...


US Patent US9012461 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36K7
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM155542
PNG
(US9012461, 18)
Show SMILES CNC(=O)Cc1ccccc1CCc1nc(Nc2cccc(c2)N2CCN(C)CC2)ncc1C(F)(F)F
Show InChI InChI=1S/C27H31F3N6O/c1-31-25(37)16-20-7-4-3-6-19(20)10-11-24-23(27(28,29)30)18-32-26(34-24)33-21-8-5-9-22(17-21)36-14-12-35(2)13-15-36/h3-9,17-18H,10-16H2,1-2H3,(H,31,37)(H,32,33,34)
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n/an/a 13n/an/an/an/an/an/a



Cancer Therapeutics CRC Pty Ltd

US Patent


Assay Description
A biotin labeled peptide is used as substrate (amino acid sequence: Biotin-Glu-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2)1S...


US Patent US9012461 (2015)


BindingDB Entry DOI: 10.7270/Q2RN36K7
More data for this
Ligand-Target Pair
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