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Compile Data Set for Download or QSAR

Found 45 hits from Carlsson Research AB   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM50171241
PNG
(2-Phenyl-3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-in...)
Show SMILES C1CC(=CCN1)c1c([nH]c2ccccc12)-c1ccccc1
Show InChI InChI=1S/C19H18N2/c1-2-6-15(7-3-1)19-18(14-10-12-20-13-11-14)16-8-4-5-9-17(16)21-19/h1-10,20-21H,11-13H2
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n/an/a 2n/an/an/an/an/an/a



Carlsson Research AB

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD binding to cloned human 5-hydroxytryptamine 6 receptor expressed in HEK cells


Bioorg Med Chem Lett 15: 4230-4 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.067
BindingDB Entry DOI: 10.7270/Q2ZG6RST
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM50171235
PNG
(5-Chloro-2-methyl-3-(1,2,3,6-tetrahydro-pyridin-4-...)
Show SMILES Cc1[nH]c2ccc(Cl)cc2c1C1=CCNCC1
Show InChI InChI=1S/C14H15ClN2/c1-9-14(10-4-6-16-7-5-10)12-8-11(15)2-3-13(12)17-9/h2-4,8,16-17H,5-7H2,1H3
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n/an/a 7.40n/an/an/an/an/an/a



Carlsson Research AB

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 6 receptor in human


Bioorg Med Chem Lett 15: 4230-4 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.067
BindingDB Entry DOI: 10.7270/Q2ZG6RST
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM50171235
PNG
(5-Chloro-2-methyl-3-(1,2,3,6-tetrahydro-pyridin-4-...)
Show SMILES Cc1[nH]c2ccc(Cl)cc2c1C1=CCNCC1
Show InChI InChI=1S/C14H15ClN2/c1-9-14(10-4-6-16-7-5-10)12-8-11(15)2-3-13(12)17-9/h2-4,8,16-17H,5-7H2,1H3
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n/an/a 7.40n/an/an/an/an/an/a



Carlsson Research AB

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD binding to cloned human 5-hydroxytryptamine 6 receptor expressed in HEK cells


Bioorg Med Chem Lett 15: 4230-4 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.067
BindingDB Entry DOI: 10.7270/Q2ZG6RST
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM50171237
PNG
(5-Chloro-2-methyl-3-(1-methyl-1,2,3,6-tetrahydro-p...)
Show SMILES CN1CCC(=CC1)c1c(C)[nH]c2ccc(Cl)cc12
Show InChI InChI=1S/C15H17ClN2/c1-10-15(11-5-7-18(2)8-6-11)13-9-12(16)3-4-14(13)17-10/h3-5,9,17H,6-8H2,1-2H3
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n/an/a 10n/an/an/an/an/an/a



Carlsson Research AB

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD binding to cloned human 5-hydroxytryptamine 6 receptor expressed in HEK cells


Bioorg Med Chem Lett 15: 4230-4 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.067
BindingDB Entry DOI: 10.7270/Q2ZG6RST
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM50171239
PNG
(5-Chloro-2-ethyl-3-(1,2,3,6-tetrahydro-pyridin-4-y...)
Show SMILES CCc1[nH]c2ccc(Cl)cc2c1C1=CCNCC1
Show InChI InChI=1S/C15H17ClN2/c1-2-13-15(10-5-7-17-8-6-10)12-9-11(16)3-4-14(12)18-13/h3-5,9,17-18H,2,6-8H2,1H3
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n/an/a 30n/an/an/an/an/an/a



Carlsson Research AB

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD binding to cloned human 5-hydroxytryptamine 6 receptor expressed in HEK cells


Bioorg Med Chem Lett 15: 4230-4 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.067
BindingDB Entry DOI: 10.7270/Q2ZG6RST
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM50171242
PNG
(5-Chloro-3-(1-ethyl-1,2,3,6-tetrahydro-pyridin-4-y...)
Show SMILES CCN1CCC(=CC1)c1c(C)[nH]c2ccc(Cl)cc12
Show InChI InChI=1S/C16H19ClN2/c1-3-19-8-6-12(7-9-19)16-11(2)18-15-5-4-13(17)10-14(15)16/h4-6,10,18H,3,7-9H2,1-2H3
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n/an/a 30n/an/an/an/an/an/a



Carlsson Research AB

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD binding to cloned human 5-hydroxytryptamine 6 receptor expressed in HEK cells


Bioorg Med Chem Lett 15: 4230-4 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.067
BindingDB Entry DOI: 10.7270/Q2ZG6RST
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))
BDBM50171235
PNG
(5-Chloro-2-methyl-3-(1,2,3,6-tetrahydro-pyridin-4-...)
Show SMILES Cc1[nH]c2ccc(Cl)cc2c1C1=CCNCC1
Show InChI InChI=1S/C14H15ClN2/c1-9-14(10-4-6-16-7-5-10)12-8-11(15)2-3-13(12)17-9/h2-4,8,16-17H,5-7H2,1H3
PDB

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n/an/a 34n/an/an/an/an/an/a



Carlsson Research AB

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 3 receptor expressed in NG 108 cells


Bioorg Med Chem Lett 15: 4230-4 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.067
BindingDB Entry DOI: 10.7270/Q2ZG6RST
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM50171234
PNG
(CHEMBL365751 | [2-(5-Chloro-2-methyl-1H-indol-3-yl...)
Show SMILES CN(C)CCc1c(C)[nH]c2ccc(Cl)cc12
Show InChI InChI=1S/C13H17ClN2/c1-9-11(6-7-16(2)3)12-8-10(14)4-5-13(12)15-9/h4-5,8,15H,6-7H2,1-3H3
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n/an/a 40n/an/an/an/an/an/a



Carlsson Research AB

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD binding to cloned human 5-hydroxytryptamine 6 receptor expressed in HEK cells


Bioorg Med Chem Lett 15: 4230-4 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.067
BindingDB Entry DOI: 10.7270/Q2ZG6RST
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM50171245
PNG
(5-Chloro-2-propyl-3-(1,2,3,6-tetrahydro-pyridin-4-...)
Show SMILES CCCc1[nH]c2ccc(Cl)cc2c1C1=CCNCC1
Show InChI InChI=1S/C16H19ClN2/c1-2-3-15-16(11-6-8-18-9-7-11)13-10-12(17)4-5-14(13)19-15/h4-6,10,18-19H,2-3,7-9H2,1H3
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n/an/a 40n/an/an/an/an/an/a



Carlsson Research AB

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD binding to cloned human 5-hydroxytryptamine 6 receptor expressed in HEK cells


Bioorg Med Chem Lett 15: 4230-4 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.067
BindingDB Entry DOI: 10.7270/Q2ZG6RST
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM50171243
PNG
(5-Chloro-2-methyl-3-(8-methyl-8-aza-bicyclo[3.2.1]...)
Show SMILES CN1C2CCC1C=C(C2)c1c(C)[nH]c2ccc(Cl)cc12
Show InChI InChI=1S/C17H19ClN2/c1-10-17(15-9-12(18)3-6-16(15)19-10)11-7-13-4-5-14(8-11)20(13)2/h3,6-7,9,13-14,19H,4-5,8H2,1-2H3
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n/an/a 40n/an/an/an/an/an/a



Carlsson Research AB

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD binding to cloned human 5-hydroxytryptamine 6 receptor expressed in HEK cells


Bioorg Med Chem Lett 15: 4230-4 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.067
BindingDB Entry DOI: 10.7270/Q2ZG6RST
More data for this
Ligand-Target Pair
HTR4


(GUINEA PIG)
BDBM34142
PNG
(2-ethyl-5-methoxy-N,N-dimethyltryptamine | CHEMBL2...)
Show SMILES CCc1[nH]c2ccc(OC)cc2c1CCN(C)C
Show InChI InChI=1S/C15H22N2O/c1-5-14-12(8-9-17(2)3)13-10-11(18-4)6-7-15(13)16-14/h6-7,10,16H,5,8-9H2,1-4H3
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n/an/a 44n/an/an/an/an/an/a



Carlsson Research AB

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 4 receptor in guinea pig


Bioorg Med Chem Lett 15: 4230-4 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.067
BindingDB Entry DOI: 10.7270/Q2ZG6RST
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM50171240
PNG
(3-(1-Butyl-1,2,3,6-tetrahydro-pyridin-4-yl)-5-chlo...)
Show SMILES CCCCN1CCC(=CC1)c1c(C)[nH]c2ccc(Cl)cc12
Show InChI InChI=1S/C18H23ClN2/c1-3-4-9-21-10-7-14(8-11-21)18-13(2)20-17-6-5-15(19)12-16(17)18/h5-7,12,20H,3-4,8-11H2,1-2H3
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n/an/a 50n/an/an/an/an/an/a



Carlsson Research AB

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD binding to cloned human 5-hydroxytryptamine 6 receptor expressed in HEK cells


Bioorg Med Chem Lett 15: 4230-4 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.067
BindingDB Entry DOI: 10.7270/Q2ZG6RST
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM50171246
PNG
(5-Chloro-2-methyl-3-(1-propyl-1,2,3,6-tetrahydro-p...)
Show SMILES CCCN1CCC(=CC1)c1c(C)[nH]c2ccc(Cl)cc12
Show InChI InChI=1S/C17H21ClN2/c1-3-8-20-9-6-13(7-10-20)17-12(2)19-16-5-4-14(18)11-15(16)17/h4-6,11,19H,3,7-10H2,1-2H3
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n/an/a 60n/an/an/an/an/an/a



Carlsson Research AB

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD binding to cloned human 5-hydroxytryptamine 6 receptor expressed in HEK cells


Bioorg Med Chem Lett 15: 4230-4 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.067
BindingDB Entry DOI: 10.7270/Q2ZG6RST
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM50171244
PNG
(5-Chloro-2-ethyl-3-(1-ethyl-1,2,3,6-tetrahydro-pyr...)
Show SMILES CCN1CCC(=CC1)c1c(CC)[nH]c2ccc(Cl)cc12
Show InChI InChI=1S/C17H21ClN2/c1-3-15-17(12-7-9-20(4-2)10-8-12)14-11-13(18)5-6-16(14)19-15/h5-7,11,19H,3-4,8-10H2,1-2H3
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n/an/a 70n/an/an/an/an/an/a



Carlsson Research AB

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD binding to cloned human 5-hydroxytryptamine 6 receptor expressed in HEK cells


Bioorg Med Chem Lett 15: 4230-4 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.067
BindingDB Entry DOI: 10.7270/Q2ZG6RST
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM81498
PNG
(5-Methoxy-3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-i...)
Show SMILES COc1ccc2[nH]cc(C3=CCNCC3)c2c1
Show InChI InChI=1S/C14H16N2O/c1-17-11-2-3-14-12(8-11)13(9-16-14)10-4-6-15-7-5-10/h2-4,8-9,15-16H,5-7H2,1H3
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n/an/a 79n/an/an/an/an/an/a



Carlsson Research AB

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD binding to cloned human 5-hydroxytryptamine 6 receptor expressed in HEK cells


Bioorg Med Chem Lett 15: 4230-4 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.067
BindingDB Entry DOI: 10.7270/Q2ZG6RST
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM50171236
PNG
(5-Methoxy-2-methyl-3-(1,2,3,6-tetrahydro-pyridin-4...)
Show SMILES COc1ccc2[nH]c(C)c(C3=CCNCC3)c2c1
Show InChI InChI=1S/C15H18N2O/c1-10-15(11-5-7-16-8-6-11)13-9-12(18-2)3-4-14(13)17-10/h3-5,9,16-17H,6-8H2,1-2H3
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n/an/a 80n/an/an/an/an/an/a



Carlsson Research AB

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD binding to cloned human 5-hydroxytryptamine 6 receptor expressed in HEK cells


Bioorg Med Chem Lett 15: 4230-4 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.067
BindingDB Entry DOI: 10.7270/Q2ZG6RST
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM50171236
PNG
(5-Methoxy-2-methyl-3-(1,2,3,6-tetrahydro-pyridin-4...)
Show SMILES COc1ccc2[nH]c(C)c(C3=CCNCC3)c2c1
Show InChI InChI=1S/C15H18N2O/c1-10-15(11-5-7-16-8-6-11)13-9-12(18-2)3-4-14(13)17-10/h3-5,9,16-17H,6-8H2,1-2H3
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n/an/a 80n/an/an/an/an/an/a



Carlsson Research AB

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 6 receptor in human


Bioorg Med Chem Lett 15: 4230-4 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.067
BindingDB Entry DOI: 10.7270/Q2ZG6RST
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM34142
PNG
(2-ethyl-5-methoxy-N,N-dimethyltryptamine | CHEMBL2...)
Show SMILES CCc1[nH]c2ccc(OC)cc2c1CCN(C)C
Show InChI InChI=1S/C15H22N2O/c1-5-14-12(8-9-17(2)3)13-10-11(18-4)6-7-15(13)16-14/h6-7,10,16H,5,8-9H2,1-4H3
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n/an/a 85n/an/an/an/an/an/a



Carlsson Research AB

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 6 receptor in human


Bioorg Med Chem Lett 15: 4230-4 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.067
BindingDB Entry DOI: 10.7270/Q2ZG6RST
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM34142
PNG
(2-ethyl-5-methoxy-N,N-dimethyltryptamine | CHEMBL2...)
Show SMILES CCc1[nH]c2ccc(OC)cc2c1CCN(C)C
Show InChI InChI=1S/C15H22N2O/c1-5-14-12(8-9-17(2)3)13-10-11(18-4)6-7-15(13)16-14/h6-7,10,16H,5,8-9H2,1-4H3
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n/an/a 85n/an/an/an/an/an/a



Carlsson Research AB

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD binding to cloned human 5-hydroxytryptamine 6 receptor stably expressed in HEK cells


Bioorg Med Chem Lett 15: 4230-4 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.067
BindingDB Entry DOI: 10.7270/Q2ZG6RST
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM50171233
PNG
(2-Ethyl-5-methoxy-3-(1,2,3,6-tetrahydro-pyridin-4-...)
Show SMILES CCc1[nH]c2ccc(OC)cc2c1C1=CCNCC1
Show InChI InChI=1S/C16H20N2O/c1-3-14-16(11-6-8-17-9-7-11)13-10-12(19-2)4-5-15(13)18-14/h4-6,10,17-18H,3,7-9H2,1-2H3
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n/an/a 90n/an/an/an/an/an/a



Carlsson Research AB

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD binding to cloned h5-HT6 receptors stably expressed in HEK cells


Bioorg Med Chem Lett 15: 4230-4 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.067
BindingDB Entry DOI: 10.7270/Q2ZG6RST
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM50171238
PNG
(5-Chloro-2-isopropyl-3-(1,2,3,6-tetrahydro-pyridin...)
Show SMILES CC(C)c1[nH]c2ccc(Cl)cc2c1C1=CCNCC1
Show InChI InChI=1S/C16H19ClN2/c1-10(2)16-15(11-5-7-18-8-6-11)13-9-12(17)3-4-14(13)19-16/h3-5,9-10,18-19H,6-8H2,1-2H3
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n/an/a 100n/an/an/an/an/an/a



Carlsson Research AB

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD binding to cloned human 5-hydroxytryptamine 6 receptor expressed in HEK cells


Bioorg Med Chem Lett 15: 4230-4 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.067
BindingDB Entry DOI: 10.7270/Q2ZG6RST
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (human))
BDBM50171235
PNG
(5-Chloro-2-methyl-3-(1,2,3,6-tetrahydro-pyridin-4-...)
Show SMILES Cc1[nH]c2ccc(Cl)cc2c1C1=CCNCC1
Show InChI InChI=1S/C14H15ClN2/c1-9-14(10-4-6-16-7-5-10)12-8-11(15)2-3-13(12)17-9/h2-4,8,16-17H,5-7H2,1H3
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n/an/a 110n/an/an/an/an/an/a



Carlsson Research AB

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 1B receptor in calf


Bioorg Med Chem Lett 15: 4230-4 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.067
BindingDB Entry DOI: 10.7270/Q2ZG6RST
More data for this
Ligand-Target Pair
Serotonin 1B/1D receptor


(Rattus norvegicus (Rat))
BDBM50171235
PNG
(5-Chloro-2-methyl-3-(1,2,3,6-tetrahydro-pyridin-4-...)
Show SMILES Cc1[nH]c2ccc(Cl)cc2c1C1=CCNCC1
Show InChI InChI=1S/C14H15ClN2/c1-9-14(10-4-6-16-7-5-10)12-8-11(15)2-3-13(12)17-9/h2-4,8,16-17H,5-7H2,1H3
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n/an/a 180n/an/an/an/an/an/a



Carlsson Research AB

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 1B receptor in rat


Bioorg Med Chem Lett 15: 4230-4 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.067
BindingDB Entry DOI: 10.7270/Q2ZG6RST
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50171235
PNG
(5-Chloro-2-methyl-3-(1,2,3,6-tetrahydro-pyridin-4-...)
Show SMILES Cc1[nH]c2ccc(Cl)cc2c1C1=CCNCC1
Show InChI InChI=1S/C14H15ClN2/c1-9-14(10-4-6-16-7-5-10)12-8-11(15)2-3-13(12)17-9/h2-4,8,16-17H,5-7H2,1H3
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Carlsson Research AB

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 2A receptor in human


Bioorg Med Chem Lett 15: 4230-4 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.067
BindingDB Entry DOI: 10.7270/Q2ZG6RST
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM50171247
PNG
(2-Ethyl-5-methoxy-3-piperidin-4-yl-1H-indole | CHE...)
Show SMILES CCc1[nH]c2ccc(OC)cc2c1C1CCNCC1
Show InChI InChI=1S/C16H22N2O/c1-3-14-16(11-6-8-17-9-7-11)13-10-12(19-2)4-5-15(13)18-14/h4-5,10-11,17-18H,3,6-9H2,1-2H3
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Carlsson Research AB

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD binding to cloned h5-HT6 receptors stably expressed in HEK cells


Bioorg Med Chem Lett 15: 4230-4 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.067
BindingDB Entry DOI: 10.7270/Q2ZG6RST
More data for this
Ligand-Target Pair
Serotonin 1B/1D receptor


(Rattus norvegicus (Rat))
BDBM50171236
PNG
(5-Methoxy-2-methyl-3-(1,2,3,6-tetrahydro-pyridin-4...)
Show SMILES COc1ccc2[nH]c(C)c(C3=CCNCC3)c2c1
Show InChI InChI=1S/C15H18N2O/c1-10-15(11-5-7-16-8-6-11)13-9-12(18-2)3-4-14(13)17-10/h3-5,9,16-17H,6-8H2,1-2H3
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Carlsson Research AB

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 1B receptor in rat


Bioorg Med Chem Lett 15: 4230-4 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.067
BindingDB Entry DOI: 10.7270/Q2ZG6RST
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50171236
PNG
(5-Methoxy-2-methyl-3-(1,2,3,6-tetrahydro-pyridin-4...)
Show SMILES COc1ccc2[nH]c(C)c(C3=CCNCC3)c2c1
Show InChI InChI=1S/C15H18N2O/c1-10-15(11-5-7-16-8-6-11)13-9-12(18-2)3-4-14(13)17-10/h3-5,9,16-17H,6-8H2,1-2H3
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Carlsson Research AB

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 1A receptor in rat


Bioorg Med Chem Lett 15: 4230-4 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.067
BindingDB Entry DOI: 10.7270/Q2ZG6RST
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (human))
BDBM50171235
PNG
(5-Chloro-2-methyl-3-(1,2,3,6-tetrahydro-pyridin-4-...)
Show SMILES Cc1[nH]c2ccc(Cl)cc2c1C1=CCNCC1
Show InChI InChI=1S/C14H15ClN2/c1-9-14(10-4-6-16-7-5-10)12-8-11(15)2-3-13(12)17-9/h2-4,8,16-17H,5-7H2,1H3
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Carlsson Research AB

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 2C receptor in human


Bioorg Med Chem Lett 15: 4230-4 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.067
BindingDB Entry DOI: 10.7270/Q2ZG6RST
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM50171248
PNG
(3-(1-Benzyl-1,2,3,6-tetrahydro-pyridin-4-yl)-5-chl...)
Show SMILES Cc1[nH]c2ccc(Cl)cc2c1C1=CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C21H21ClN2/c1-15-21(19-13-18(22)7-8-20(19)23-15)17-9-11-24(12-10-17)14-16-5-3-2-4-6-16/h2-9,13,23H,10-12,14H2,1H3
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n/an/a 600n/an/an/an/an/an/a



Carlsson Research AB

Curated by ChEMBL


Assay Description
Displacement of [3H]-LSD binding to cloned human 5-hydroxytryptamine 6 receptor expressed in HEK cells


Bioorg Med Chem Lett 15: 4230-4 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.067
BindingDB Entry DOI: 10.7270/Q2ZG6RST
More data for this
Ligand-Target Pair
HTR4


(GUINEA PIG)
BDBM50171235
PNG
(5-Chloro-2-methyl-3-(1,2,3,6-tetrahydro-pyridin-4-...)
Show SMILES Cc1[nH]c2ccc(Cl)cc2c1C1=CCNCC1
Show InChI InChI=1S/C14H15ClN2/c1-9-14(10-4-6-16-7-5-10)12-8-11(15)2-3-13(12)17-9/h2-4,8,16-17H,5-7H2,1H3
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n/an/a 620n/an/an/an/an/an/a



Carlsson Research AB

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 4 receptor in guinea pig


Bioorg Med Chem Lett 15: 4230-4 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.067
BindingDB Entry DOI: 10.7270/Q2ZG6RST
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM34142
PNG
(2-ethyl-5-methoxy-N,N-dimethyltryptamine | CHEMBL2...)
Show SMILES CCc1[nH]c2ccc(OC)cc2c1CCN(C)C
Show InChI InChI=1S/C15H22N2O/c1-5-14-12(8-9-17(2)3)13-10-11(18-4)6-7-15(13)16-14/h6-7,10,16H,5,8-9H2,1-4H3
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n/an/a 620n/an/an/an/an/an/a



Carlsson Research AB

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 2A receptor in human


Bioorg Med Chem Lett 15: 4230-4 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.067
BindingDB Entry DOI: 10.7270/Q2ZG6RST
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50171235
PNG
(5-Chloro-2-methyl-3-(1,2,3,6-tetrahydro-pyridin-4-...)
Show SMILES Cc1[nH]c2ccc(Cl)cc2c1C1=CCNCC1
Show InChI InChI=1S/C14H15ClN2/c1-9-14(10-4-6-16-7-5-10)12-8-11(15)2-3-13(12)17-9/h2-4,8,16-17H,5-7H2,1H3
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Carlsson Research AB

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 1A receptor in rat


Bioorg Med Chem Lett 15: 4230-4 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.067
BindingDB Entry DOI: 10.7270/Q2ZG6RST
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (human))
BDBM50171236
PNG
(5-Methoxy-2-methyl-3-(1,2,3,6-tetrahydro-pyridin-4...)
Show SMILES COc1ccc2[nH]c(C)c(C3=CCNCC3)c2c1
Show InChI InChI=1S/C15H18N2O/c1-10-15(11-5-7-16-8-6-11)13-9-12(18-2)3-4-14(13)17-10/h3-5,9,16-17H,6-8H2,1-2H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



Carlsson Research AB

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 2C receptor in human


Bioorg Med Chem Lett 15: 4230-4 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.067
BindingDB Entry DOI: 10.7270/Q2ZG6RST
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))
BDBM50171236
PNG
(5-Methoxy-2-methyl-3-(1,2,3,6-tetrahydro-pyridin-4...)
Show SMILES COc1ccc2[nH]c(C)c(C3=CCNCC3)c2c1
Show InChI InChI=1S/C15H18N2O/c1-10-15(11-5-7-16-8-6-11)13-9-12(18-2)3-4-14(13)17-10/h3-5,9,16-17H,6-8H2,1-2H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



Carlsson Research AB

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 3 receptor expressed in NG 108 cells


Bioorg Med Chem Lett 15: 4230-4 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.067
BindingDB Entry DOI: 10.7270/Q2ZG6RST
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM34142
PNG
(2-ethyl-5-methoxy-N,N-dimethyltryptamine | CHEMBL2...)
Show SMILES CCc1[nH]c2ccc(OC)cc2c1CCN(C)C
Show InChI InChI=1S/C15H22N2O/c1-5-14-12(8-9-17(2)3)13-10-11(18-4)6-7-15(13)16-14/h6-7,10,16H,5,8-9H2,1-4H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



Carlsson Research AB

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 1A receptor in rat


Bioorg Med Chem Lett 15: 4230-4 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.067
BindingDB Entry DOI: 10.7270/Q2ZG6RST
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A


(Homo sapiens (Human))
BDBM34142
PNG
(2-ethyl-5-methoxy-N,N-dimethyltryptamine | CHEMBL2...)
Show SMILES CCc1[nH]c2ccc(OC)cc2c1CCN(C)C
Show InChI InChI=1S/C15H22N2O/c1-5-14-12(8-9-17(2)3)13-10-11(18-4)6-7-15(13)16-14/h6-7,10,16H,5,8-9H2,1-4H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



Carlsson Research AB

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 3 receptor expressed in NG 108 cells


Bioorg Med Chem Lett 15: 4230-4 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.067
BindingDB Entry DOI: 10.7270/Q2ZG6RST
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (human))
BDBM50171236
PNG
(5-Methoxy-2-methyl-3-(1,2,3,6-tetrahydro-pyridin-4...)
Show SMILES COc1ccc2[nH]c(C)c(C3=CCNCC3)c2c1
Show InChI InChI=1S/C15H18N2O/c1-10-15(11-5-7-16-8-6-11)13-9-12(18-2)3-4-14(13)17-10/h3-5,9,16-17H,6-8H2,1-2H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



Carlsson Research AB

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 1D receptor in calf


Bioorg Med Chem Lett 15: 4230-4 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.067
BindingDB Entry DOI: 10.7270/Q2ZG6RST
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM50171236
PNG
(5-Methoxy-2-methyl-3-(1,2,3,6-tetrahydro-pyridin-4...)
Show SMILES COc1ccc2[nH]c(C)c(C3=CCNCC3)c2c1
Show InChI InChI=1S/C15H18N2O/c1-10-15(11-5-7-16-8-6-11)13-9-12(18-2)3-4-14(13)17-10/h3-5,9,16-17H,6-8H2,1-2H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



Carlsson Research AB

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 2A receptor in human


Bioorg Med Chem Lett 15: 4230-4 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.067
BindingDB Entry DOI: 10.7270/Q2ZG6RST
More data for this
Ligand-Target Pair
Serotonin 1B/1D receptor


(Rattus norvegicus (Rat))
BDBM34142
PNG
(2-ethyl-5-methoxy-N,N-dimethyltryptamine | CHEMBL2...)
Show SMILES CCc1[nH]c2ccc(OC)cc2c1CCN(C)C
Show InChI InChI=1S/C15H22N2O/c1-5-14-12(8-9-17(2)3)13-10-11(18-4)6-7-15(13)16-14/h6-7,10,16H,5,8-9H2,1-4H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



Carlsson Research AB

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 1B receptor in rat


Bioorg Med Chem Lett 15: 4230-4 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.067
BindingDB Entry DOI: 10.7270/Q2ZG6RST
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D


(Homo sapiens (human))
BDBM34142
PNG
(2-ethyl-5-methoxy-N,N-dimethyltryptamine | CHEMBL2...)
Show SMILES CCc1[nH]c2ccc(OC)cc2c1CCN(C)C
Show InChI InChI=1S/C15H22N2O/c1-5-14-12(8-9-17(2)3)13-10-11(18-4)6-7-15(13)16-14/h6-7,10,16H,5,8-9H2,1-4H3
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n/an/a 1.40E+3n/an/an/an/an/an/a



Carlsson Research AB

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 1D receptor in calf


Bioorg Med Chem Lett 15: 4230-4 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.067
BindingDB Entry DOI: 10.7270/Q2ZG6RST
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 7 (5-HT7)


(Homo sapiens (human))
BDBM34142
PNG
(2-ethyl-5-methoxy-N,N-dimethyltryptamine | CHEMBL2...)
Show SMILES CCc1[nH]c2ccc(OC)cc2c1CCN(C)C
Show InChI InChI=1S/C15H22N2O/c1-5-14-12(8-9-17(2)3)13-10-11(18-4)6-7-15(13)16-14/h6-7,10,16H,5,8-9H2,1-4H3
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n/an/a 1.50E+3n/an/an/an/an/an/a



Carlsson Research AB

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 7 receptor in human


Bioorg Med Chem Lett 15: 4230-4 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.067
BindingDB Entry DOI: 10.7270/Q2ZG6RST
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 7 (5-HT7)


(Homo sapiens (human))
BDBM50171235
PNG
(5-Chloro-2-methyl-3-(1,2,3,6-tetrahydro-pyridin-4-...)
Show SMILES Cc1[nH]c2ccc(Cl)cc2c1C1=CCNCC1
Show InChI InChI=1S/C14H15ClN2/c1-9-14(10-4-6-16-7-5-10)12-8-11(15)2-3-13(12)17-9/h2-4,8,16-17H,5-7H2,1H3
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n/an/a 3.00E+3n/an/an/an/an/an/a



Carlsson Research AB

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 7 receptor in human


Bioorg Med Chem Lett 15: 4230-4 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.067
BindingDB Entry DOI: 10.7270/Q2ZG6RST
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (human))
BDBM34142
PNG
(2-ethyl-5-methoxy-N,N-dimethyltryptamine | CHEMBL2...)
Show SMILES CCc1[nH]c2ccc(OC)cc2c1CCN(C)C
Show InChI InChI=1S/C15H22N2O/c1-5-14-12(8-9-17(2)3)13-10-11(18-4)6-7-15(13)16-14/h6-7,10,16H,5,8-9H2,1-4H3
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PubMed
n/an/a 5.50E+3n/an/an/an/an/an/a



Carlsson Research AB

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 2C receptor in human


Bioorg Med Chem Lett 15: 4230-4 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.067
BindingDB Entry DOI: 10.7270/Q2ZG6RST
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 7 (5-HT7)


(Homo sapiens (human))
BDBM50171236
PNG
(5-Methoxy-2-methyl-3-(1,2,3,6-tetrahydro-pyridin-4...)
Show SMILES COc1ccc2[nH]c(C)c(C3=CCNCC3)c2c1
Show InChI InChI=1S/C15H18N2O/c1-10-15(11-5-7-16-8-6-11)13-9-12(18-2)3-4-14(13)17-10/h3-5,9,16-17H,6-8H2,1-2H3
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PubMed
n/an/a 9.80E+3n/an/an/an/an/an/a



Carlsson Research AB

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 7 receptor in human


Bioorg Med Chem Lett 15: 4230-4 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.067
BindingDB Entry DOI: 10.7270/Q2ZG6RST
More data for this
Ligand-Target Pair
HTR4


(GUINEA PIG)
BDBM50171236
PNG
(5-Methoxy-2-methyl-3-(1,2,3,6-tetrahydro-pyridin-4...)
Show SMILES COc1ccc2[nH]c(C)c(C3=CCNCC3)c2c1
Show InChI InChI=1S/C15H18N2O/c1-10-15(11-5-7-16-8-6-11)13-9-12(18-2)3-4-14(13)17-10/h3-5,9,16-17H,6-8H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


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Article
PubMed
n/an/a 9.80E+3n/an/an/an/an/an/a



Carlsson Research AB

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-hydroxytryptamine 4 receptor in guinea pig


Bioorg Med Chem Lett 15: 4230-4 (2005)


Article DOI: 10.1016/j.bmcl.2005.06.067
BindingDB Entry DOI: 10.7270/Q2ZG6RST
More data for this
Ligand-Target Pair