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Compile Data Set for Download or QSAR

Found 109 hits from Carpibem   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Angiotensin II AT1B


(RAT)
BDBM50039364
PNG
(5-Methyl-7-propyl-8-[2'-(1H-tetrazol-5-yl)-bipheny...)
Show SMILES CCCc1nc(C)n2nc(N)nc2c1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C23H23N9/c1-3-6-20-19(22-26-23(24)29-32(22)14(2)25-20)13-15-9-11-16(12-10-15)17-7-4-5-8-18(17)21-27-30-31-28-21/h4-5,7-12H,3,6,13H2,1-2H3,(H2,24,29)(H,27,28,30,31)
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1n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor


J Med Chem 37: 2371-86 (1994)


Article DOI: 10.1021/jm00041a016
BindingDB Entry DOI: 10.7270/Q2DR2TJS
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50009714
PNG
(CHEMBL191 | {2-Butyl-5-chloro-3-[2'-(2H-tetrazol-5...)
Show SMILES CCCCC1=NC(Cl)C(CO)N1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C22H25ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,19,21,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28)
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3.60n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor


J Med Chem 37: 2371-86 (1994)


Article DOI: 10.1021/jm00041a016
BindingDB Entry DOI: 10.7270/Q2DR2TJS
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047064
PNG
(4-[5-Fluoro-1-(4-methoxy-benzyl)-1H-benzoimidazol-...)
Show SMILES COc1ccc(Cn2c(CC(C)(C)CC(O)=O)nc3cc(F)ccc23)cc1
Show InChI InChI=1S/C21H23FN2O3/c1-21(2,12-20(25)26)11-19-23-17-10-15(22)6-9-18(17)24(19)13-14-4-7-16(27-3)8-5-14/h4-10H,11-13H2,1-3H3,(H,25,26)
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4n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Tested in vitro for inhibition constant against TXA2 / PGH-2 receptor using [125I]-PTA-OH binding affinity to human platelets


J Med Chem 36: 1175-87 (1993)


Article DOI: 10.1021/jm00061a008
BindingDB Entry DOI: 10.7270/Q2R49PT8
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047082
PNG
(4-[5-Fluoro-1-(4-methylsulfanyl-benzyl)-1H-benzoim...)
Show SMILES CSc1ccc(Cn2c(CC(C)(C)CC(O)=O)nc3cc(F)ccc23)cc1
Show InChI InChI=1S/C21H23FN2O2S/c1-21(2,12-20(25)26)11-19-23-17-10-15(22)6-9-18(17)24(19)13-14-4-7-16(27-3)8-5-14/h4-10H,11-13H2,1-3H3,(H,25,26)
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5n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Tested in vitro for inhibition constant against TXA2 / PGH-2 receptor using [125I]-PTA-OH binding affinity to human platelets


J Med Chem 36: 1175-87 (1993)


Article DOI: 10.1021/jm00061a008
BindingDB Entry DOI: 10.7270/Q2R49PT8
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50039376
PNG
(CHEMBL80773 | {5-Methyl-7-propyl-8-[2'-(1H-tetrazo...)
Show SMILES CCCc1nc(C)n2nc(CO)nc2c1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C24H24N8O/c1-3-6-21-20(24-26-22(14-33)29-32(24)15(2)25-21)13-16-9-11-17(12-10-16)18-7-4-5-8-19(18)23-27-30-31-28-23/h4-5,7-12,33H,3,6,13-14H2,1-2H3,(H,27,28,30,31)
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5n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor


J Med Chem 37: 2371-86 (1994)


Article DOI: 10.1021/jm00041a016
BindingDB Entry DOI: 10.7270/Q2DR2TJS
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50039345
PNG
(CHEMBL77783 | Methyl-{5-methyl-7-propyl-8-[2'-(1H-...)
Show SMILES CCCc1nc(C)n2nc(NC)nc2c1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C24H25N9/c1-4-7-21-20(23-27-24(25-3)30-33(23)15(2)26-21)14-16-10-12-17(13-11-16)18-8-5-6-9-19(18)22-28-31-32-29-22/h5-6,8-13H,4,7,14H2,1-3H3,(H,25,30)(H,28,29,31,32)
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5n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor


J Med Chem 37: 2371-86 (1994)


Article DOI: 10.1021/jm00041a016
BindingDB Entry DOI: 10.7270/Q2DR2TJS
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047054
PNG
(4-[1-(3,4-Dichloro-benzyl)-5-fluoro-1H-benzoimidaz...)
Show SMILES CC(C)(CC(O)=O)Cc1nc2cc(F)ccc2n1Cc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C20H19Cl2FN2O2/c1-20(2,10-19(26)27)9-18-24-16-8-13(23)4-6-17(16)25(18)11-12-3-5-14(21)15(22)7-12/h3-8H,9-11H2,1-2H3,(H,26,27)
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6n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Tested in vitro for inhibition constant against TXA2 / PGH-2 receptor using [125I]-PTA-OH binding affinity to human platelets


J Med Chem 36: 1175-87 (1993)


Article DOI: 10.1021/jm00061a008
BindingDB Entry DOI: 10.7270/Q2R49PT8
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047068
PNG
(4-[5-Chloro-1-(4-methylsulfanyl-benzyl)-1H-benzoim...)
Show SMILES CSc1ccc(Cn2c(CC(C)(C)CC(O)=O)nc3cc(Cl)ccc23)cc1
Show InChI InChI=1S/C21H23ClN2O2S/c1-21(2,12-20(25)26)11-19-23-17-10-15(22)6-9-18(17)24(19)13-14-4-7-16(27-3)8-5-14/h4-10H,11-13H2,1-3H3,(H,25,26)
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6n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Tested in vitro for inhibition constant against TXA2 / PGH-2 receptor using [125I]-PTA-OH binding affinity to human platelets


J Med Chem 36: 1175-87 (1993)


Article DOI: 10.1021/jm00061a008
BindingDB Entry DOI: 10.7270/Q2R49PT8
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50039366
PNG
(2-(2-Hydroxy-ethyl)-5-methyl-7-propyl-8-[2'-(1H-te...)
Show SMILES CCCc1nc(C)n2c(nn(CCO)c2=O)c1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C25H26N8O2/c1-3-6-22-21(24-29-32(13-14-34)25(35)33(24)16(2)26-22)15-17-9-11-18(12-10-17)19-7-4-5-8-20(19)23-27-30-31-28-23/h4-5,7-12,34H,3,6,13-15H2,1-2H3,(H,27,28,30,31)
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6n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor


J Med Chem 37: 2371-86 (1994)


Article DOI: 10.1021/jm00041a016
BindingDB Entry DOI: 10.7270/Q2DR2TJS
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047081
PNG
(4-[6-Chloro-3-(4-methylsulfanyl-benzyl)-3H-imidazo...)
Show SMILES CSc1ccc(Cn2c(CC(C)(C)CC(O)=O)nc3cc(Cl)cnc23)cc1
Show InChI InChI=1S/C20H22ClN3O2S/c1-20(2,10-18(25)26)9-17-23-16-8-14(21)11-22-19(16)24(17)12-13-4-6-15(27-3)7-5-13/h4-8,11H,9-10,12H2,1-3H3,(H,25,26)
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7n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Tested in vitro for inhibition constant against TXA2 / PGH-2 receptor using [125I]-PTA-OH binding affinity to human platelets


J Med Chem 36: 1175-87 (1993)


Article DOI: 10.1021/jm00061a008
BindingDB Entry DOI: 10.7270/Q2R49PT8
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))
BDBM50368929
PNG
(CHEMBL610155)
Show SMILES O[C@H]1[C@@H](O)C(O[C@@H]1C(=O)NC1CC1)n1cnc2c(NCCc3cn(CC4CC4)c4ccccc34)ncnc12
Show InChI InChI=1S/C27H31N7O4/c35-21-22(36)27(38-23(21)26(37)32-17-7-8-17)34-14-31-20-24(29-13-30-25(20)34)28-10-9-16-12-33(11-15-5-6-15)19-4-2-1-3-18(16)19/h1-4,12-15,17,21-23,27,35-36H,5-11H2,(H,32,37)(H,28,29,30)/t21-,22+,23-,27?/m0/s1
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7n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Binding affinity for adenosine A1 receptor in vitro using rat brain membranes.


J Med Chem 37: 4307-16 (1995)


Article DOI: 10.1021/jm00051a007
BindingDB Entry DOI: 10.7270/Q2J38T68
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))
BDBM50453502
PNG
(CHEMBL2113573)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1C(=O)NC1CC1)n1cnc2c(NCCc3cn(CCN4CCCC4)c4ccccc34)ncnc12
Show InChI InChI=1S/C29H36N8O4/c38-23-24(39)29(41-25(23)28(40)34-19-7-8-19)37-17-33-22-26(31-16-32-27(22)37)30-10-9-18-15-36(14-13-35-11-3-4-12-35)21-6-2-1-5-20(18)21/h1-2,5-6,15-17,19,23-25,29,38-39H,3-4,7-14H2,(H,34,40)(H,30,31,32)/t23-,24+,25-,29+/m0/s1
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7.5n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Binding affinity for adenosine A1 receptor in vitro using rat brain membranes.


J Med Chem 37: 4307-16 (1995)


Article DOI: 10.1021/jm00051a007
BindingDB Entry DOI: 10.7270/Q2J38T68
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047065
PNG
(4-[1-(4-Chloro-benzyl)-5-fluoro-1H-benzoimidazol-2...)
Show SMILES CC(C)(CC(O)=O)Cc1nc2cc(F)ccc2n1Cc1ccc(Cl)cc1
Show InChI InChI=1S/C20H20ClFN2O2/c1-20(2,11-19(25)26)10-18-23-16-9-15(22)7-8-17(16)24(18)12-13-3-5-14(21)6-4-13/h3-9H,10-12H2,1-2H3,(H,25,26)
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7.80n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Tested in vitro for inhibition constant against TXA2 / PGH-2 receptor using [125I]-PTA-OH binding affinity to human platelets


J Med Chem 36: 1175-87 (1993)


Article DOI: 10.1021/jm00061a008
BindingDB Entry DOI: 10.7270/Q2R49PT8
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))
BDBM50453499
PNG
(CHEMBL2113598)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1C(=O)NC1CC1)n1cnc2c(NCCc3c[nH]c4ccccc34)ncnc12
Show InChI InChI=1S/C23H25N7O4/c31-17-18(32)23(34-19(17)22(33)29-13-5-6-13)30-11-28-16-20(26-10-27-21(16)30)24-8-7-12-9-25-15-4-2-1-3-14(12)15/h1-4,9-11,13,17-19,23,25,31-32H,5-8H2,(H,29,33)(H,24,26,27)/t17-,18+,19-,23+/m0/s1
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7.90n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Binding affinity for adenosine A1 receptor in rat brain membrane


J Med Chem 37: 4307-16 (1995)


Article DOI: 10.1021/jm00051a007
BindingDB Entry DOI: 10.7270/Q2J38T68
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50039344
PNG
(2-Ethyl-5-methyl-7-propyl-8-[2'-(1H-tetrazol-5-yl)...)
Show SMILES CCCc1nc(C)n2nc(CC)nc2c1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C25H26N8/c1-4-8-22-21(25-27-23(5-2)30-33(25)16(3)26-22)15-17-11-13-18(14-12-17)19-9-6-7-10-20(19)24-28-31-32-29-24/h6-7,9-14H,4-5,8,15H2,1-3H3,(H,28,29,31,32)
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8n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor


J Med Chem 37: 2371-86 (1994)


Article DOI: 10.1021/jm00041a016
BindingDB Entry DOI: 10.7270/Q2DR2TJS
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))
BDBM50368937
PNG
(CHEMBL609252)
Show SMILES O[C@H]1[C@@H](O)C(O[C@@H]1C(=O)NC1CC1)n1cnc2c(NCCc3cn(CCN4CCCCC4)c4ccccc34)ncnc12
Show InChI InChI=1S/C30H38N8O4/c39-24-25(40)30(42-26(24)29(41)35-20-8-9-20)38-18-34-23-27(32-17-33-28(23)38)31-11-10-19-16-37(22-7-3-2-6-21(19)22)15-14-36-12-4-1-5-13-36/h2-3,6-7,16-18,20,24-26,30,39-40H,1,4-5,8-15H2,(H,35,41)(H,31,32,33)/t24-,25+,26-,30?/m0/s1
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8.30n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Binding affinity for adenosine A1 receptor in vitro using rat brain membranes.


J Med Chem 37: 4307-16 (1995)


Article DOI: 10.1021/jm00051a007
BindingDB Entry DOI: 10.7270/Q2J38T68
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50039372
PNG
(CHEMBL80380 | {5-Methyl-7-propyl-8-[2'-(1H-tetrazo...)
Show SMILES CCCc1nc(C)n2nc(CC(=O)OCC)nc2c1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C27H28N8O2/c1-4-8-23-22(27-29-24(16-25(36)37-5-2)32-35(27)17(3)28-23)15-18-11-13-19(14-12-18)20-9-6-7-10-21(20)26-30-33-34-31-26/h6-7,9-14H,4-5,8,15-16H2,1-3H3,(H,30,31,33,34)
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9n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor


J Med Chem 37: 2371-86 (1994)


Article DOI: 10.1021/jm00041a016
BindingDB Entry DOI: 10.7270/Q2DR2TJS
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50039341
PNG
(5-Methyl-7-propyl-8-[2'-(1H-tetrazol-5-yl)-bipheny...)
Show SMILES CCCc1nc(C)n2c(n[nH]c2=O)c1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C23H22N8O/c1-3-6-20-19(22-27-28-23(32)31(22)14(2)24-20)13-15-9-11-16(12-10-15)17-7-4-5-8-18(17)21-25-29-30-26-21/h4-5,7-12H,3,6,13H2,1-2H3,(H,28,32)(H,25,26,29,30)
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10n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor


J Med Chem 37: 2371-86 (1994)


Article DOI: 10.1021/jm00041a016
BindingDB Entry DOI: 10.7270/Q2DR2TJS
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50039350
PNG
(5-Hydroxymethyl-7-propyl-8-[2'-(1H-tetrazol-5-yl)-...)
Show SMILES CCCc1nc(CO)n2[nH]c(=O)nc2c1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C23H22N8O2/c1-2-5-19-18(22-25-23(33)28-31(22)20(13-32)24-19)12-14-8-10-15(11-9-14)16-6-3-4-7-17(16)21-26-29-30-27-21/h3-4,6-11,32H,2,5,12-13H2,1H3,(H,28,33)(H,26,27,29,30)
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10n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor


J Med Chem 37: 2371-86 (1994)


Article DOI: 10.1021/jm00041a016
BindingDB Entry DOI: 10.7270/Q2DR2TJS
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50039362
PNG
(5-Methyl-7-propyl-8-[2'-(1H-tetrazol-5-yl)-bipheny...)
Show SMILES CCCc1nc(C)n2[nH]c(=S)nc2c1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C23H22N8S/c1-3-6-20-19(22-25-23(32)28-31(22)14(2)24-20)13-15-9-11-16(12-10-15)17-7-4-5-8-18(17)21-26-29-30-27-21/h4-5,7-12H,3,6,13H2,1-2H3,(H,28,32)(H,26,27,29,30)
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10n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor


J Med Chem 37: 2371-86 (1994)


Article DOI: 10.1021/jm00041a016
BindingDB Entry DOI: 10.7270/Q2DR2TJS
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50039378
PNG
(5-Methyl-7-propyl-8-[2'-(1H-tetrazol-5-yl)-bipheny...)
Show SMILES CCCc1nc(C)n2cnnc2c1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C23H22N8/c1-3-6-21-20(23-28-24-14-31(23)15(2)25-21)13-16-9-11-17(12-10-16)18-7-4-5-8-19(18)22-26-29-30-27-22/h4-5,7-12,14H,3,6,13H2,1-2H3,(H,26,27,29,30)
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10n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor


J Med Chem 37: 2371-86 (1994)


Article DOI: 10.1021/jm00041a016
BindingDB Entry DOI: 10.7270/Q2DR2TJS
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50039346
PNG
(5-Methyl-7-propyl-8-[2'-(1H-tetrazol-5-yl)-bipheny...)
Show SMILES CCCc1nc(C)n2nc(nc2c1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)S(N)(=O)=O
Show InChI InChI=1S/C23H23N9O2S/c1-3-6-20-19(22-26-23(35(24,33)34)29-32(22)14(2)25-20)13-15-9-11-16(12-10-15)17-7-4-5-8-18(17)21-27-30-31-28-21/h4-5,7-12H,3,6,13H2,1-2H3,(H2,24,33,34)(H,27,28,30,31)
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11n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor


J Med Chem 37: 2371-86 (1994)


Article DOI: 10.1021/jm00041a016
BindingDB Entry DOI: 10.7270/Q2DR2TJS
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))
BDBM50453507
PNG
(CHEMBL2113584)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(NCCc3cn(Cc4ccc(Cl)cc4)c4ccccc34)ncnc12
Show InChI InChI=1S/C27H27ClN6O4/c28-18-7-5-16(6-8-18)11-33-12-17(19-3-1-2-4-20(19)33)9-10-29-25-22-26(31-14-30-25)34(15-32-22)27-24(37)23(36)21(13-35)38-27/h1-8,12,14-15,21,23-24,27,35-37H,9-11,13H2,(H,29,30,31)/t21-,23-,24-,27-/m1/s1
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11n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Binding affinity for adenosine A1 receptor in vitro using rat brain membranes.


J Med Chem 37: 4307-16 (1995)


Article DOI: 10.1021/jm00051a007
BindingDB Entry DOI: 10.7270/Q2J38T68
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047058
PNG
(4-[1-(4-Bromo-2-fluoro-benzyl)-1H-benzoimidazol-2-...)
Show SMILES CC(C)(CC(O)=O)Cc1nc2ccccc2n1Cc1ccc(Br)cc1F
Show InChI InChI=1S/C20H20BrFN2O2/c1-20(2,11-19(25)26)10-18-23-16-5-3-4-6-17(16)24(18)12-13-7-8-14(21)9-15(13)22/h3-9H,10-12H2,1-2H3,(H,25,26)
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11n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Tested in vitro for inhibition constant against TXA2 / PGH-2 receptor using [125I]-PTA-OH binding affinity to human platelets


J Med Chem 36: 1175-87 (1993)


Article DOI: 10.1021/jm00061a008
BindingDB Entry DOI: 10.7270/Q2R49PT8
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50039357
PNG
(CHEMBL312632 | {5-Methyl-3-oxo-7-propyl-8-[2'-(1H-...)
Show SMILES CCCc1nc(C)n2c(nn(CC(=O)OCC)c2=O)c1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C27H28N8O3/c1-4-8-23-22(26-31-34(16-24(36)38-5-2)27(37)35(26)17(3)28-23)15-18-11-13-19(14-12-18)20-9-6-7-10-21(20)25-29-32-33-30-25/h6-7,9-14H,4-5,8,15-16H2,1-3H3,(H,29,30,32,33)
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12n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor


J Med Chem 37: 2371-86 (1994)


Article DOI: 10.1021/jm00041a016
BindingDB Entry DOI: 10.7270/Q2DR2TJS
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047076
PNG
(4-[1-(4-Bromo-benzyl)-5-fluoro-1H-benzoimidazol-2-...)
Show SMILES CC(C)(CC(O)=O)Cc1nc2cc(F)ccc2n1Cc1ccc(Br)cc1
Show InChI InChI=1S/C20H20BrFN2O2/c1-20(2,11-19(25)26)10-18-23-16-9-15(22)7-8-17(16)24(18)12-13-3-5-14(21)6-4-13/h3-9H,10-12H2,1-2H3,(H,25,26)
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12n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Tested in vitro for inhibition constant against TXA2 / PGH-2 receptor using [125I]-PTA-OH binding affinity to human platelets


J Med Chem 36: 1175-87 (1993)


Article DOI: 10.1021/jm00061a008
BindingDB Entry DOI: 10.7270/Q2R49PT8
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50039374
PNG
(5-Methyl-7-propyl-8-[2'-(1H-tetrazol-5-yl)-bipheny...)
Show SMILES CCCc1nc(C)n2ncnc2c1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C23H22N8/c1-3-6-21-20(23-24-14-25-31(23)15(2)26-21)13-16-9-11-17(12-10-16)18-7-4-5-8-19(18)22-27-29-30-28-22/h4-5,7-12,14H,3,6,13H2,1-2H3,(H,27,28,29,30)
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12n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor


J Med Chem 37: 2371-86 (1994)


Article DOI: 10.1021/jm00041a016
BindingDB Entry DOI: 10.7270/Q2DR2TJS
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047059
PNG
(4-[5-Chloro-1-(3,4-dichloro-benzyl)-1H-benzoimidaz...)
Show SMILES CC(C)(CC(O)=O)Cc1nc2cc(Cl)ccc2n1Cc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C20H19Cl3N2O2/c1-20(2,10-19(26)27)9-18-24-16-8-13(21)4-6-17(16)25(18)11-12-3-5-14(22)15(23)7-12/h3-8H,9-11H2,1-2H3,(H,26,27)
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12n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Tested in vitro for inhibition constant against TXA2 / PGH-2 receptor using [125I]-PTA-OH binding affinity to human platelets


J Med Chem 36: 1175-87 (1993)


Article DOI: 10.1021/jm00061a008
BindingDB Entry DOI: 10.7270/Q2R49PT8
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047072
PNG
(4-[1-(4-Bromo-benzyl)-5-chloro-1H-benzoimidazol-2-...)
Show SMILES CC(C)(CC(O)=O)Cc1nc2cc(Cl)ccc2n1Cc1ccc(Br)cc1
Show InChI InChI=1S/C20H20BrClN2O2/c1-20(2,11-19(25)26)10-18-23-16-9-15(22)7-8-17(16)24(18)12-13-3-5-14(21)6-4-13/h3-9H,10-12H2,1-2H3,(H,25,26)
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13n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Tested in vitro for inhibition constant against TXA2 / PGH-2 receptor using [125I]-PTA-OH binding affinity to human platelets


J Med Chem 36: 1175-87 (1993)


Article DOI: 10.1021/jm00061a008
BindingDB Entry DOI: 10.7270/Q2R49PT8
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))
BDBM50368922
PNG
(CHEMBL611311)
Show SMILES O[C@H]1[C@@H](O)C(O[C@@H]1C(=O)NC1CC1)n1cnc2c(NCCc3cn(Cc4ccccc4)c4ccccc34)ncnc12
Show InChI InChI=1S/C30H31N7O4/c38-24-25(39)30(41-26(24)29(40)35-20-10-11-20)37-17-34-23-27(32-16-33-28(23)37)31-13-12-19-15-36(14-18-6-2-1-3-7-18)22-9-5-4-8-21(19)22/h1-9,15-17,20,24-26,30,38-39H,10-14H2,(H,35,40)(H,31,32,33)/t24-,25+,26-,30?/m0/s1
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14n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Binding affinity for adenosine A1 receptor in vitro using rat brain membranes.


J Med Chem 37: 4307-16 (1995)


Article DOI: 10.1021/jm00051a007
BindingDB Entry DOI: 10.7270/Q2J38T68
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))
BDBM50368950
PNG
(CHEMBL610442)
Show SMILES Cn1cc(CCNc2ncnc3n(cnc23)C2O[C@@H]([C@@H](O)[C@H]2O)C(=O)NC2CC2)c2ccccc12
Show InChI InChI=1S/C24H27N7O4/c1-30-10-13(15-4-2-3-5-16(15)30)8-9-25-21-17-22(27-11-26-21)31(12-28-17)24-19(33)18(32)20(35-24)23(34)29-14-6-7-14/h2-5,10-12,14,18-20,24,32-33H,6-9H2,1H3,(H,29,34)(H,25,26,27)/t18-,19+,20-,24?/m0/s1
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14n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Binding affinity for adenosine A1 receptor in vitro using rat brain membranes.


J Med Chem 37: 4307-16 (1995)


Article DOI: 10.1021/jm00051a007
BindingDB Entry DOI: 10.7270/Q2J38T68
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047067
PNG
(4-[1-(4-Bromo-2-fluoro-benzyl)-5-fluoro-1H-benzoim...)
Show SMILES CC(C)(CC(O)=O)Cc1nc2cc(F)ccc2n1Cc1ccc(Br)cc1F
Show InChI InChI=1S/C20H19BrF2N2O2/c1-20(2,10-19(26)27)9-18-24-16-8-14(22)5-6-17(16)25(18)11-12-3-4-13(21)7-15(12)23/h3-8H,9-11H2,1-2H3,(H,26,27)
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15n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Tested in vitro for inhibition constant against TXA2 / PGH-2 receptor using [125I]-PTA-OH binding affinity to human platelets


J Med Chem 36: 1175-87 (1993)


Article DOI: 10.1021/jm00061a008
BindingDB Entry DOI: 10.7270/Q2R49PT8
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50039347
PNG
(2-Methoxymethyl-5-methyl-7-propyl-8-[2'-(1H-tetraz...)
Show SMILES CCCc1nc(C)n2nc(COC)nc2c1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C25H26N8O/c1-4-7-22-21(25-27-23(15-34-3)30-33(25)16(2)26-22)14-17-10-12-18(13-11-17)19-8-5-6-9-20(19)24-28-31-32-29-24/h5-6,8-13H,4,7,14-15H2,1-3H3,(H,28,29,31,32)
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15n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor


J Med Chem 37: 2371-86 (1994)


Article DOI: 10.1021/jm00041a016
BindingDB Entry DOI: 10.7270/Q2DR2TJS
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50008779
PNG
((+) [9-(4-Chloro-benzyl)-6-fluoro-2,3,4,9-tetrahyd...)
Show SMILES OC(=O)CC1CCCc2c1n(Cc1ccc(Cl)cc1)c1ccc(F)cc21
Show InChI InChI=1S/C21H19ClFNO2/c22-15-6-4-13(5-7-15)12-24-19-9-8-16(23)11-18(19)17-3-1-2-14(21(17)24)10-20(25)26/h4-9,11,14H,1-3,10,12H2,(H,25,26)
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15.3n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Tested in vitro for inhibition constant against TXA2 / PGH-2 receptor using [125I]-PTA-OH binding affinity to human platelets


J Med Chem 36: 1175-87 (1993)


Article DOI: 10.1021/jm00061a008
BindingDB Entry DOI: 10.7270/Q2R49PT8
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047079
PNG
(4-[1-(4-Bromo-benzyl)-1H-benzoimidazol-2-yl]-3,3-d...)
Show SMILES CC(C)(CC(O)=O)Cc1nc2ccccc2n1Cc1ccc(Br)cc1
Show InChI InChI=1S/C20H21BrN2O2/c1-20(2,12-19(24)25)11-18-22-16-5-3-4-6-17(16)23(18)13-14-7-9-15(21)10-8-14/h3-10H,11-13H2,1-2H3,(H,24,25)
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16n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Tested in vitro for inhibition constant against TXA2 / PGH-2 receptor using [125I]-PTA-OH binding affinity to human platelets


J Med Chem 36: 1175-87 (1993)


Article DOI: 10.1021/jm00061a008
BindingDB Entry DOI: 10.7270/Q2R49PT8
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047083
PNG
(4-[5-Chloro-1-(4-methoxy-benzyl)-1H-benzoimidazol-...)
Show SMILES COc1ccc(Cn2c(CC(C)(C)CC(O)=O)nc3cc(Cl)ccc23)cc1
Show InChI InChI=1S/C21H23ClN2O3/c1-21(2,12-20(25)26)11-19-23-17-10-15(22)6-9-18(17)24(19)13-14-4-7-16(27-3)8-5-14/h4-10H,11-13H2,1-3H3,(H,25,26)
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20n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Tested in vitro for inhibition constant against TXA2 / PGH-2 receptor using [125I]-PTA-OH binding affinity to human platelets


J Med Chem 36: 1175-87 (1993)


Article DOI: 10.1021/jm00061a008
BindingDB Entry DOI: 10.7270/Q2R49PT8
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047060
PNG
(4-[6-Chloro-3-(4-chloro-benzyl)-3H-imidazo[4,5-b]p...)
Show SMILES CC(C)(CC(O)=O)Cc1nc2cc(Cl)cnc2n1Cc1ccc(Cl)cc1
Show InChI InChI=1S/C19H19Cl2N3O2/c1-19(2,9-17(25)26)8-16-23-15-7-14(21)10-22-18(15)24(16)11-12-3-5-13(20)6-4-12/h3-7,10H,8-9,11H2,1-2H3,(H,25,26)
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21n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Tested in vitro for inhibition constant against TXA2 / PGH-2 receptor using [125I]-PTA-OH binding affinity to human platelets


J Med Chem 36: 1175-87 (1993)


Article DOI: 10.1021/jm00061a008
BindingDB Entry DOI: 10.7270/Q2R49PT8
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047062
PNG
(5-[1-(4-Chloro-benzyl)-5-fluoro-1H-benzoimidazol-2...)
Show SMILES CC(C)(CCC(O)=O)Cc1nc2cc(F)ccc2n1Cc1ccc(Cl)cc1
Show InChI InChI=1S/C21H22ClFN2O2/c1-21(2,10-9-20(26)27)12-19-24-17-11-16(23)7-8-18(17)25(19)13-14-3-5-15(22)6-4-14/h3-8,11H,9-10,12-13H2,1-2H3,(H,26,27)
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23n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Tested in vitro for inhibition constant against TXA2 / PGH-2 receptor using [125I]-PTA-OH binding affinity to human platelets


J Med Chem 36: 1175-87 (1993)


Article DOI: 10.1021/jm00061a008
BindingDB Entry DOI: 10.7270/Q2R49PT8
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))
BDBM50453512
PNG
(CHEMBL2113599)
Show SMILES COCCn1cc(CCNc2ncnc3n(cnc23)[C@@H]2O[C@@H]([C@@H](O)[C@H]2O)C(=O)NC2CC2)c2ccccc12
Show InChI InChI=1S/C26H31N7O5/c1-37-11-10-32-12-15(17-4-2-3-5-18(17)32)8-9-27-23-19-24(29-13-28-23)33(14-30-19)26-21(35)20(34)22(38-26)25(36)31-16-6-7-16/h2-5,12-14,16,20-22,26,34-35H,6-11H2,1H3,(H,31,36)(H,27,28,29)/t20-,21+,22-,26+/m0/s1
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23n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Binding affinity for adenosine A1 receptor in vitro using rat brain membranes.


J Med Chem 37: 4307-16 (1995)


Article DOI: 10.1021/jm00051a007
BindingDB Entry DOI: 10.7270/Q2J38T68
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047066
PNG
(4-[5-Chloro-1-(4-chloro-benzyl)-1H-benzoimidazol-2...)
Show SMILES CC(C)(CC(O)=O)Cc1nc2cc(Cl)ccc2n1Cc1ccc(Cl)cc1
Show InChI InChI=1S/C20H20Cl2N2O2/c1-20(2,11-19(25)26)10-18-23-16-9-15(22)7-8-17(16)24(18)12-13-3-5-14(21)6-4-13/h3-9H,10-12H2,1-2H3,(H,25,26)
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23n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Tested in vitro for inhibition constant against TXA2 / PGH-2 receptor using [125I]-PTA-OH binding affinity to human platelets


J Med Chem 36: 1175-87 (1993)


Article DOI: 10.1021/jm00061a008
BindingDB Entry DOI: 10.7270/Q2R49PT8
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50039368
PNG
(5-Methyl-7-propyl-8-[2'-(1H-tetrazol-5-yl)-bipheny...)
Show SMILES CCCc1nc(C)n2nc(nc2c1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)C(=O)OCC
Show InChI InChI=1S/C26H26N8O2/c1-4-8-22-21(25-28-24(26(35)36-5-2)31-34(25)16(3)27-22)15-17-11-13-18(14-12-17)19-9-6-7-10-20(19)23-29-32-33-30-23/h6-7,9-14H,4-5,8,15H2,1-3H3,(H,29,30,32,33)
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23n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor


J Med Chem 37: 2371-86 (1994)


Article DOI: 10.1021/jm00041a016
BindingDB Entry DOI: 10.7270/Q2DR2TJS
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50039342
PNG
(5-Methyl-7-propyl-8-[2'-(1H-tetrazol-5-yl)-bipheny...)
Show SMILES CCCc1nc(C)n2[nH]c(=O)nc2c1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C23H22N8O/c1-3-6-20-19(22-25-23(32)28-31(22)14(2)24-20)13-15-9-11-16(12-10-15)17-7-4-5-8-18(17)21-26-29-30-27-21/h4-5,7-12H,3,6,13H2,1-2H3,(H,28,32)(H,26,27,29,30)
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24n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor


J Med Chem 37: 2371-86 (1994)


Article DOI: 10.1021/jm00041a016
BindingDB Entry DOI: 10.7270/Q2DR2TJS
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))
BDBM50453510
PNG
(CHEMBL2113586)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1C(=O)NC1CC1)n1cnc2c(NCCc3cn(Cc4cccnc4)c4ccccc34)ncnc12
Show InChI InChI=1S/C29H30N8O4/c38-23-24(39)29(41-25(23)28(40)35-19-7-8-19)37-16-34-22-26(32-15-33-27(22)37)31-11-9-18-14-36(13-17-4-3-10-30-12-17)21-6-2-1-5-20(18)21/h1-6,10,12,14-16,19,23-25,29,38-39H,7-9,11,13H2,(H,35,40)(H,31,32,33)/t23-,24+,25-,29+/m0/s1
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26n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Binding affinity for adenosine A1 receptor in vitro using rat brain membranes.


J Med Chem 37: 4307-16 (1995)


Article DOI: 10.1021/jm00051a007
BindingDB Entry DOI: 10.7270/Q2J38T68
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50039370
PNG
(2-Methoxy-5-methyl-7-propyl-8-[2'-(1H-tetrazol-5-y...)
Show SMILES CCCc1nc(C)n2nc(OC)nc2c1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C24H24N8O/c1-4-7-21-20(23-26-24(33-3)29-32(23)15(2)25-21)14-16-10-12-17(13-11-16)18-8-5-6-9-19(18)22-27-30-31-28-22/h5-6,8-13H,4,7,14H2,1-3H3,(H,27,28,30,31)
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27n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor


J Med Chem 37: 2371-86 (1994)


Article DOI: 10.1021/jm00041a016
BindingDB Entry DOI: 10.7270/Q2DR2TJS
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50039371
PNG
(CHEMBL76149 | {2-Methyl-7-propyl-8-[2'-(1H-tetrazo...)
Show SMILES CCCc1nc(CO)n2nc(C)nc2c1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C24H24N8O/c1-3-6-21-20(24-25-15(2)29-32(24)22(14-33)26-21)13-16-9-11-17(12-10-16)18-7-4-5-8-19(18)23-27-30-31-28-23/h4-5,7-12,33H,3,6,13-14H2,1-2H3,(H,27,28,30,31)
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27n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor


J Med Chem 37: 2371-86 (1994)


Article DOI: 10.1021/jm00041a016
BindingDB Entry DOI: 10.7270/Q2DR2TJS
More data for this
Ligand-Target Pair
Adenosine receptor A1


(Rattus norvegicus (rat))
BDBM50453511
PNG
(CHEMBL2113587)
Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1C(=O)NC1CC1)n1cnc2c(NCCc3cn(Cc4cccc(c4)[N+]([O-])=O)c4ccccc34)ncnc12
Show InChI InChI=1S/C30H30N8O6/c39-24-25(40)30(44-26(24)29(41)35-19-8-9-19)37-16-34-23-27(32-15-33-28(23)37)31-11-10-18-14-36(22-7-2-1-6-21(18)22)13-17-4-3-5-20(12-17)38(42)43/h1-7,12,14-16,19,24-26,30,39-40H,8-11,13H2,(H,35,41)(H,31,32,33)/t24-,25+,26-,30+/m0/s1
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29n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Binding affinity for adenosine A1 receptor in vitro using rat brain membranes.


J Med Chem 37: 4307-16 (1995)


Article DOI: 10.1021/jm00051a007
BindingDB Entry DOI: 10.7270/Q2J38T68
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50039351
PNG
(7-Butyl-5-methyl-8-[2'-(1H-tetrazol-5-yl)-biphenyl...)
Show SMILES CCCCc1nc(C)n2[nH]c(=O)nc2c1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C24H24N8O/c1-3-4-9-21-20(23-26-24(33)29-32(23)15(2)25-21)14-16-10-12-17(13-11-16)18-7-5-6-8-19(18)22-27-30-31-28-22/h5-8,10-13H,3-4,9,14H2,1-2H3,(H,29,33)(H,27,28,30,31)
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30n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor


J Med Chem 37: 2371-86 (1994)


Article DOI: 10.1021/jm00041a016
BindingDB Entry DOI: 10.7270/Q2DR2TJS
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047077
PNG
(4-[1-(4-Chloro-benzyl)-1H-benzoimidazol-2-yl]-3,3-...)
Show SMILES CC(C)(CC(O)=O)Cc1nc2ccccc2n1Cc1ccc(Cl)cc1
Show InChI InChI=1S/C20H21ClN2O2/c1-20(2,12-19(24)25)11-18-22-16-5-3-4-6-17(16)23(18)13-14-7-9-15(21)10-8-14/h3-10H,11-13H2,1-2H3,(H,24,25)
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31n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Tested in vitro for inhibition constant against TXA2 / PGH-2 receptor using [125I]-PTA-OH binding affinity to human platelets


J Med Chem 36: 1175-87 (1993)


Article DOI: 10.1021/jm00061a008
BindingDB Entry DOI: 10.7270/Q2R49PT8
More data for this
Ligand-Target Pair
Prostanoid TP receptor


(Homo sapiens (Human))
BDBM50047063
PNG
(4-[1-(4-Methoxy-benzyl)-1H-benzoimidazol-2-yl]-3,3...)
Show SMILES COc1ccc(Cn2c(CC(C)(C)CC(O)=O)nc3ccccc23)cc1
Show InChI InChI=1S/C21H24N2O3/c1-21(2,13-20(24)25)12-19-22-17-6-4-5-7-18(17)23(19)14-15-8-10-16(26-3)11-9-15/h4-11H,12-14H2,1-3H3,(H,24,25)
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31n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Tested in vitro for inhibition constant against TXA2 / PGH-2 receptor using [125I]-PTA-OH binding affinity to human platelets


J Med Chem 36: 1175-87 (1993)


Article DOI: 10.1021/jm00061a008
BindingDB Entry DOI: 10.7270/Q2R49PT8
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50039369
PNG
(2,5-Dimethyl-7-propyl-8-[2'-(1H-tetrazol-5-yl)-bip...)
Show SMILES CCCc1nc(C)n2nc(C)nc2c1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C24H24N8/c1-4-7-22-21(24-25-15(2)29-32(24)16(3)26-22)14-17-10-12-18(13-11-17)19-8-5-6-9-20(19)23-27-30-31-28-23/h5-6,8-13H,4,7,14H2,1-3H3,(H,27,28,30,31)
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32n/an/an/an/an/an/an/an/a



Carpibem

Curated by ChEMBL


Assay Description
Displacement of [125I]-Sar1-Ile8-A II from rat adrenal Angiotensin-1 (AT-1) receptor


J Med Chem 37: 2371-86 (1994)


Article DOI: 10.1021/jm00041a016
BindingDB Entry DOI: 10.7270/Q2DR2TJS
More data for this
Ligand-Target Pair
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