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Compile Data Set for Download or QSAR

Found 2 hits from Catabasis Pharmaceuticals   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sterol regulatory element-binding protein 2


(Homo sapiens)
BDBM50159362
PNG
(CHEMBL3785912)
Show SMILES CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)NCCNC(=O)c1cccnc1
Show InChI InChI=1S/C28H39N3O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-21-27(32)30-23-24-31-28(33)26-20-19-22-29-25-26/h3-4,6-7,9-10,12-13,15-16,19-20,22,25H,2,5,8,11,14,17-18,21,23-24H2,1H3,(H,30,32)(H,31,33)/b4-3-,7-6-,10-9-,13-12-,16-15-
PDB
MMDB

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PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.70E+4n/an/an/an/an/an/a



Catabasis Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of SREBP2 in human HepG2 cells assessed as reduction of PCSK9 secretion after 16 hrs by ELISA


J Med Chem 59: 1217-31 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01961
BindingDB Entry DOI: 10.7270/Q2G162QT
More data for this
Ligand-Target Pair
Hydroxycarboxylic acid receptor 2


(Homo sapiens (human))
BDBM23515
PNG
(CHEMBL573 | Niacin | Nicotinic Acid | [5, 6-3H]-ni...)
Show SMILES OC(=O)c1cccnc1
Show InChI InChI=1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9)
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KEGG

UniProtKB/SwissProt

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CHEMBL
DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents


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DrugBank
Article
PubMed
n/an/an/an/a 730n/an/an/an/a



Catabasis Pharmaceuticals

Curated by ChEMBL


Assay Description
Activation of GPR109A in human A431 cells assessed as suppression of forskolin-induced cAMP production after 30 mins


J Med Chem 59: 1217-31 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01961
BindingDB Entry DOI: 10.7270/Q2G162QT
More data for this
Ligand-Target Pair