BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 194 hits from Celgene CAR LLC; Sanofi   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88559
PNG
(US9695132, I-1)
Show SMILES CCC(=O)Nc1cccc(CN2C(=O)N(Cc3cnc(Nc4ccccc4NC(=O)C=C)nc23)c2c(Cl)c(OC)cc(OC)c2Cl)c1
Show InChI InChI=1S/C33H31Cl2N7O5/c1-5-26(43)37-21-11-9-10-19(14-21)17-42-31-20(16-36-32(40-31)39-23-13-8-7-12-22(23)38-27(44)6-2)18-41(33(42)45)30-28(34)24(46-3)15-25(47-4)29(30)35/h6-16H,2,5,17-18H2,1,3-4H3,(H,37,43)(H,38,44)(H,36,39,40)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


US Patent US9695132 (2017)


BindingDB Entry DOI: 10.7270/Q2TX3CJ7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88560
PNG
(US9695132, I-2 | US9695132, I-65)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)nc3N(C)C2=O)c1Cl
Show InChI InChI=1S/C24H22Cl2N6O4/c1-5-18(33)28-14-8-6-7-9-15(14)29-23-27-11-13-12-32(24(34)31(2)22(13)30-23)21-19(25)16(35-3)10-17(36-4)20(21)26/h5-11H,1,12H2,2-4H3,(H,28,33)(H,27,29,30)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. b) [FGFR4-WT]=2.5 nM, [ATP]=250 uM, [Y10-Sox]=10 uM (ATP KMapp 250 uM): A 10x stoc...


US Patent US9695132 (2017)


BindingDB Entry DOI: 10.7270/Q2TX3CJ7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88561
PNG
(US9695132, I-3)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)nc3N(Cc3ccccc3)C2=O)c1Cl
Show InChI InChI=1S/C30H26Cl2N6O4/c1-4-24(39)34-20-12-8-9-13-21(20)35-29-33-15-19-17-37(27-25(31)22(41-2)14-23(42-3)26(27)32)30(40)38(28(19)36-29)16-18-10-6-5-7-11-18/h4-15H,1,16-17H2,2-3H3,(H,34,39)(H,33,35,36)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. b) [FGFR4-WT]=2.5 nM, [ATP]=250 uM, [Y10-Sox]=10 uM (ATP KMapp 250 uM): A 10x stoc...


US Patent US9695132 (2017)


BindingDB Entry DOI: 10.7270/Q2TX3CJ7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88563
PNG
(US9695132, I-5)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccccc3NC(=O)C=C)nc2N(C)C1=O
Show InChI InChI=1S/C24H24N6O4/c1-5-21(31)26-19-8-6-7-9-20(19)27-23-25-13-15-14-30(24(32)29(2)22(15)28-23)16-10-17(33-3)12-18(11-16)34-4/h5-13H,1,14H2,2-4H3,(H,26,31)(H,25,27,28)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


US Patent US9695132 (2017)


BindingDB Entry DOI: 10.7270/Q2TX3CJ7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88566
PNG
(US9695132, I-8)
Show SMILES CCC(=O)Nc1cccc(CN2C(=O)N(Cc3cnc(NC4CCCCC4NC(=O)C=C)nc23)c2c(Cl)c(OC)cc(OC)c2Cl)c1
Show InChI InChI=1S/C33H37Cl2N7O5/c1-5-26(43)37-21-11-9-10-19(14-21)17-42-31-20(16-36-32(40-31)39-23-13-8-7-12-22(23)38-27(44)6-2)18-41(33(42)45)30-28(34)24(46-3)15-25(47-4)29(30)35/h6,9-11,14-16,22-23H,2,5,7-8,12-13,17-18H2,1,3-4H3,(H,37,43)(H,38,44)(H,36,39,40)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. b) [FGFR4-WT]=2.5 nM, [ATP]=250 uM, [Y10-Sox]=10 uM (ATP KMapp 250 uM): A 10x stoc...


US Patent US9695132 (2017)


BindingDB Entry DOI: 10.7270/Q2TX3CJ7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88567
PNG
(US9695132, I-9)
Show SMILES CCC(=O)Nc1cccc(CN2C(=O)N(Cc3cnc(Nc4ccc(cc4NC(=O)C=C)N4CCN(CCOC)CC4)nc23)c2cc(OC)cc(OC)c2)c1
Show InChI InChI=1S/C40H47N9O6/c1-6-36(50)42-29-10-8-9-27(19-29)25-49-38-28(26-48(40(49)52)31-20-32(54-4)23-33(21-31)55-5)24-41-39(45-38)44-34-12-11-30(22-35(34)43-37(51)7-2)47-15-13-46(14-16-47)17-18-53-3/h7-12,19-24H,2,6,13-18,25-26H2,1,3-5H3,(H,42,50)(H,43,51)(H,41,44,45)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. b) [FGFR4-WT]=2.5 nM, [ATP]=250 uM, [Y10-Sox]=10 uM (ATP KMapp 250 uM): A 10x stoc...


US Patent US9695132 (2017)


BindingDB Entry DOI: 10.7270/Q2TX3CJ7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88651
PNG
(US9695132, I-14)
Show SMILES COCCOc1ccc(Nc2ncc3CN(C(=O)N(Cc4ccccc4)c3n2)c2cc(OC)cc(OC)c2)c(NC(=O)C=C)c1
Show InChI InChI=1S/C33H34N6O6/c1-5-30(40)35-29-18-25(45-14-13-42-2)11-12-28(29)36-32-34-19-23-21-38(24-15-26(43-3)17-27(16-24)44-4)33(41)39(31(23)37-32)20-22-9-7-6-8-10-22/h5-12,15-19H,1,13-14,20-21H2,2-4H3,(H,35,40)(H,34,36,37)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. b) [FGFR4-WT]=2.5 nM, [ATP]=250 uM, [Y10-Sox]=10 uM (ATP KMapp 250 uM): A 10x stoc...


US Patent US9695132 (2017)


BindingDB Entry DOI: 10.7270/Q2TX3CJ7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88652
PNG
(US9695132, I-15)
Show SMILES CCN1CCN(CC1)c1ccc(Nc2ncc3CN(C(=O)N(C)c3n2)c2cc(OC)cc(OC)c2)c(NC(=O)C=C)c1
Show InChI InChI=1S/C30H36N8O4/c1-6-27(39)32-26-16-21(37-12-10-36(7-2)11-13-37)8-9-25(26)33-29-31-18-20-19-38(30(40)35(3)28(20)34-29)22-14-23(41-4)17-24(15-22)42-5/h6,8-9,14-18H,1,7,10-13,19H2,2-5H3,(H,32,39)(H,31,33,34)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. b) [FGFR4-WT]=2.5 nM, [ATP]=250 uM, [Y10-Sox]=10 uM (ATP KMapp 250 uM): A 10x stoc...


US Patent US9695132 (2017)


BindingDB Entry DOI: 10.7270/Q2TX3CJ7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88654
PNG
(US9695132, I-17)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccc(cc3NC(=O)C=C)N3CCOCC3)nc2N(C)C1=O
Show InChI InChI=1S/C28H31N7O5/c1-5-25(36)30-24-14-19(34-8-10-40-11-9-34)6-7-23(24)31-27-29-16-18-17-35(28(37)33(2)26(18)32-27)20-12-21(38-3)15-22(13-20)39-4/h5-7,12-16H,1,8-11,17H2,2-4H3,(H,30,36)(H,29,31,32)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


US Patent US9695132 (2017)


BindingDB Entry DOI: 10.7270/Q2TX3CJ7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88657
PNG
(US9695132, I-20)
Show SMILES COCCN1CCN(CC1)c1ccc(Nc2ncc3CN(C(=O)N(C)c3n2)c2cc(OC)cc(OC)c2)c(NC(=O)C=C)c1
Show InChI InChI=1S/C31H38N8O5/c1-6-28(40)33-27-17-22(38-11-9-37(10-12-38)13-14-42-3)7-8-26(27)34-30-32-19-21-20-39(31(41)36(2)29(21)35-30)23-15-24(43-4)18-25(16-23)44-5/h6-8,15-19H,1,9-14,20H2,2-5H3,(H,33,40)(H,32,34,35)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. b) [FGFR4-WT]=2.5 nM, [ATP]=250 uM, [Y10-Sox]=10 uM (ATP KMapp 250 uM): A 10x stoc...


US Patent US9695132 (2017)


BindingDB Entry DOI: 10.7270/Q2TX3CJ7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88658
PNG
(US9695132, I-21)
Show SMILES COCCN(C)c1ccc(Nc2ncc3CN(C(=O)N(C)c3n2)c2cc(OC)cc(OC)c2)c(NC(=O)C=C)c1
Show InChI InChI=1S/C28H33N7O5/c1-7-25(36)30-24-14-19(33(2)10-11-38-4)8-9-23(24)31-27-29-16-18-17-35(28(37)34(3)26(18)32-27)20-12-21(39-5)15-22(13-20)40-6/h7-9,12-16H,1,10-11,17H2,2-6H3,(H,30,36)(H,29,31,32)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


US Patent US9695132 (2017)


BindingDB Entry DOI: 10.7270/Q2TX3CJ7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88660
PNG
(US9695132, I-23)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)nc3N(C3CC3)C2=O)c1Cl
Show InChI InChI=1S/C26H24Cl2N6O4/c1-4-20(35)30-16-7-5-6-8-17(16)31-25-29-12-14-13-33(26(36)34(15-9-10-15)24(14)32-25)23-21(27)18(37-2)11-19(38-3)22(23)28/h4-8,11-12,15H,1,9-10,13H2,2-3H3,(H,30,35)(H,29,31,32)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. b) [FGFR4-WT]=2.5 nM, [ATP]=250 uM, [Y10-Sox]=10 uM (ATP KMapp 250 uM): A 10x stoc...


US Patent US9695132 (2017)


BindingDB Entry DOI: 10.7270/Q2TX3CJ7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88661
PNG
(US9695132, I-24)
Show SMILES COc1cc(CN2C(=O)N(Cc3cnc(Nc4ccccc4NC(=O)C=C)nc23)c2c(Cl)c(OC)cc(OC)c2Cl)ccc1Cl
Show InChI InChI=1S/C31H27Cl3N6O5/c1-5-25(41)36-20-8-6-7-9-21(20)37-30-35-14-18-16-39(28-26(33)23(44-3)13-24(45-4)27(28)34)31(42)40(29(18)38-30)15-17-10-11-19(32)22(12-17)43-2/h5-14H,1,15-16H2,2-4H3,(H,36,41)(H,35,37,38)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. b) [FGFR4-WT]=2.5 nM, [ATP]=250 uM, [Y10-Sox]=10 uM (ATP KMapp 250 uM): A 10x stoc...


US Patent US9695132 (2017)


BindingDB Entry DOI: 10.7270/Q2TX3CJ7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88663
PNG
(US9695132, I-26)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)nc3N(Cc3cccc(N)c3)C2=O)c1Cl
Show InChI InChI=1S/C30H27Cl2N7O4/c1-4-24(40)35-20-10-5-6-11-21(20)36-29-34-14-18-16-38(27-25(31)22(42-2)13-23(43-3)26(27)32)30(41)39(28(18)37-29)15-17-8-7-9-19(33)12-17/h4-14H,1,15-16,33H2,2-3H3,(H,35,40)(H,34,36,37)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. b) [FGFR4-WT]=2.5 nM, [ATP]=250 uM, [Y10-Sox]=10 uM (ATP KMapp 250 uM): A 10x stoc...


US Patent US9695132 (2017)


BindingDB Entry DOI: 10.7270/Q2TX3CJ7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88664
PNG
(US9695132, I-27)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3cc(ccc3NC(=O)C=C)-c3cnn(C)c3)nc2N(C)C1=O
Show InChI InChI=1S/C28H28N8O4/c1-6-25(37)31-23-8-7-17(18-14-30-34(2)15-18)9-24(23)32-27-29-13-19-16-36(28(38)35(3)26(19)33-27)20-10-21(39-4)12-22(11-20)40-5/h6-15H,1,16H2,2-5H3,(H,31,37)(H,29,32,33)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


US Patent US9695132 (2017)


BindingDB Entry DOI: 10.7270/Q2TX3CJ7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88665
PNG
(US9695132, I-28)
Show SMILES COc1cccc(CN2C(=O)N(Cc3cnc(Nc4ccccc4NC(=O)C=C)nc23)c2c(Cl)c(OC)cc(OC)c2Cl)c1
Show InChI InChI=1S/C31H28Cl2N6O5/c1-5-25(40)35-21-11-6-7-12-22(21)36-30-34-15-19-17-38(28-26(32)23(43-3)14-24(44-4)27(28)33)31(41)39(29(19)37-30)16-18-9-8-10-20(13-18)42-2/h5-15H,1,16-17H2,2-4H3,(H,35,40)(H,34,36,37)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


US Patent US9695132 (2017)


BindingDB Entry DOI: 10.7270/Q2TX3CJ7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88667
PNG
(US9695132, I-30)
Show SMILES CCN1CCN(CC1)c1ccc(NC(=O)C=C)c(Nc2ncc3CN(C(=O)N(C)c3n2)c2cc(OC)cc(OC)c2)c1
Show InChI InChI=1S/C30H36N8O4/c1-6-27(39)32-25-9-8-21(37-12-10-36(7-2)11-13-37)16-26(25)33-29-31-18-20-19-38(30(40)35(3)28(20)34-29)22-14-23(41-4)17-24(15-22)42-5/h6,8-9,14-18H,1,7,10-13,19H2,2-5H3,(H,32,39)(H,31,33,34)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


US Patent US9695132 (2017)


BindingDB Entry DOI: 10.7270/Q2TX3CJ7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88668
PNG
(US9695132, I-31)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccc(cc3NC(=O)C=C)N3CCCCC3)nc2N(C)C1=O
Show InChI InChI=1S/C29H33N7O4/c1-5-26(37)31-25-15-20(35-11-7-6-8-12-35)9-10-24(25)32-28-30-17-19-18-36(29(38)34(2)27(19)33-28)21-13-22(39-3)16-23(14-21)40-4/h5,9-10,13-17H,1,6-8,11-12,18H2,2-4H3,(H,31,37)(H,30,32,33)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


US Patent US9695132 (2017)


BindingDB Entry DOI: 10.7270/Q2TX3CJ7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88669
PNG
(US9695132, I-32)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccccc3NC(=O)C=C)nc2N(CC=C)C1=O
Show InChI InChI=1S/C26H26N6O4/c1-5-11-31-24-17(16-32(26(31)34)18-12-19(35-3)14-20(13-18)36-4)15-27-25(30-24)29-22-10-8-7-9-21(22)28-23(33)6-2/h5-10,12-15H,1-2,11,16H2,3-4H3,(H,28,33)(H,27,29,30)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


US Patent US9695132 (2017)


BindingDB Entry DOI: 10.7270/Q2TX3CJ7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88671
PNG
(US9695132, I-34)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccccc3NC(=O)C=C)nc2N(C2CC2)C1=O
Show InChI InChI=1S/C26H26N6O4/c1-4-23(33)28-21-7-5-6-8-22(21)29-25-27-14-16-15-31(18-11-19(35-2)13-20(12-18)36-3)26(34)32(17-9-10-17)24(16)30-25/h4-8,11-14,17H,1,9-10,15H2,2-3H3,(H,28,33)(H,27,29,30)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


US Patent US9695132 (2017)


BindingDB Entry DOI: 10.7270/Q2TX3CJ7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88672
PNG
(US9695132, I-35)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(NC4CCCCC4NC(=O)C=C)nc3N(Cc3cccnc3)C2=O)c1Cl
Show InChI InChI=1S/C29H31Cl2N7O4/c1-4-23(39)34-19-9-5-6-10-20(19)35-28-33-14-18-16-37(26-24(30)21(41-2)12-22(42-3)25(26)31)29(40)38(27(18)36-28)15-17-8-7-11-32-13-17/h4,7-8,11-14,19-20H,1,5-6,9-10,15-16H2,2-3H3,(H,34,39)(H,33,35,36)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


US Patent US9695132 (2017)


BindingDB Entry DOI: 10.7270/Q2TX3CJ7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88673
PNG
(US9695132, I-36)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccccc3NC(=O)C=C)nc2N(C2CCCN(C2)C(=O)OC(C)(C)C)C1=O
Show InChI InChI=1S/C33H39N7O6/c1-7-28(41)35-26-12-8-9-13-27(26)36-30-34-18-21-19-39(23-15-24(44-5)17-25(16-23)45-6)31(42)40(29(21)37-30)22-11-10-14-38(20-22)32(43)46-33(2,3)4/h7-9,12-13,15-18,22H,1,10-11,14,19-20H2,2-6H3,(H,35,41)(H,34,36,37)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


US Patent US9695132 (2017)


BindingDB Entry DOI: 10.7270/Q2TX3CJ7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88681
PNG
(US9695132, I-40)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccccc3NC(=O)C=C)nc2N(CC2CCNCC2)C1=O
Show InChI InChI=1S/C29H33N7O4/c1-4-26(37)32-24-7-5-6-8-25(24)33-28-31-16-20-18-35(21-13-22(39-2)15-23(14-21)40-3)29(38)36(27(20)34-28)17-19-9-11-30-12-10-19/h4-8,13-16,19,30H,1,9-12,17-18H2,2-3H3,(H,32,37)(H,31,33,34)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


US Patent US9695132 (2017)


BindingDB Entry DOI: 10.7270/Q2TX3CJ7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88683
PNG
(US9695132, I-41)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccc(C)cc3NC(=O)C=C)nc2N(C)C1=O
Show InChI InChI=1S/C25H26N6O4/c1-6-22(32)27-21-9-15(2)7-8-20(21)28-24-26-13-16-14-31(25(33)30(3)23(16)29-24)17-10-18(34-4)12-19(11-17)35-5/h6-13H,1,14H2,2-5H3,(H,27,32)(H,26,28,29)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


US Patent US9695132 (2017)


BindingDB Entry DOI: 10.7270/Q2TX3CJ7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88684
PNG
(US9695132, I-42)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccc(cc3NC(=O)C=C)C(F)(F)F)nc2N(C)C1=O
Show InChI InChI=1S/C25H23F3N6O4/c1-5-21(35)30-20-8-15(25(26,27)28)6-7-19(20)31-23-29-12-14-13-34(24(36)33(2)22(14)32-23)16-9-17(37-3)11-18(10-16)38-4/h5-12H,1,13H2,2-4H3,(H,30,35)(H,29,31,32)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


US Patent US9695132 (2017)


BindingDB Entry DOI: 10.7270/Q2TX3CJ7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88685
PNG
(US9695132, I-43)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccccc3NC(=O)C=C)nc2N(C2CCCNC2)C1=O
Show InChI InChI=1S/C28H31N7O4/c1-4-25(36)31-23-9-5-6-10-24(23)32-27-30-15-18-17-34(20-12-21(38-2)14-22(13-20)39-3)28(37)35(26(18)33-27)19-8-7-11-29-16-19/h4-6,9-10,12-15,19,29H,1,7-8,11,16-17H2,2-3H3,(H,31,36)(H,30,32,33)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


US Patent US9695132 (2017)


BindingDB Entry DOI: 10.7270/Q2TX3CJ7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88686
PNG
(US9695132, I-44)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccccc3NC(=O)C=C)nc2N(Cc2cccnc2)C1=O
Show InChI InChI=1S/C29H27N7O4/c1-4-26(37)32-24-9-5-6-10-25(24)33-28-31-16-20-18-35(21-12-22(39-2)14-23(13-21)40-3)29(38)36(27(20)34-28)17-19-8-7-11-30-15-19/h4-16H,1,17-18H2,2-3H3,(H,32,37)(H,31,33,34)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


US Patent US9695132 (2017)


BindingDB Entry DOI: 10.7270/Q2TX3CJ7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88690
PNG
(US9695132, I-47)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(NC4CCCCC4NC(=O)C=C)nc3N(CC#N)C2=O)c1Cl
Show InChI InChI=1S/C25H27Cl2N7O4/c1-4-19(35)30-15-7-5-6-8-16(15)31-24-29-12-14-13-34(25(36)33(10-9-28)23(14)32-24)22-20(26)17(37-2)11-18(38-3)21(22)27/h4,11-12,15-16H,1,5-8,10,13H2,2-3H3,(H,30,35)(H,29,31,32)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


US Patent US9695132 (2017)


BindingDB Entry DOI: 10.7270/Q2TX3CJ7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM89503
PNG
(US9695132, I-48)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccccc3NC(=O)C=C)nc2N(CC#N)C1=O
Show InChI InChI=1S/C25H23N7O4/c1-4-22(33)28-20-7-5-6-8-21(20)29-24-27-14-16-15-32(25(34)31(10-9-26)23(16)30-24)17-11-18(35-2)13-19(12-17)36-3/h4-8,11-14H,1,10,15H2,2-3H3,(H,28,33)(H,27,29,30)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


US Patent US9695132 (2017)


BindingDB Entry DOI: 10.7270/Q2TX3CJ7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM89509
PNG
(US9695132, I-49)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3cc(C)ccc3NC(=O)C=C)nc2N(C)C1=O
Show InChI InChI=1S/C25H26N6O4/c1-6-22(32)27-20-8-7-15(2)9-21(20)28-24-26-13-16-14-31(25(33)30(3)23(16)29-24)17-10-18(34-4)12-19(11-17)35-5/h6-13H,1,14H2,2-5H3,(H,27,32)(H,26,28,29)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


US Patent US9695132 (2017)


BindingDB Entry DOI: 10.7270/Q2TX3CJ7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM89510
PNG
(US9695132, I-50)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3cc(ccc3NC(=O)C=C)C(F)(F)F)nc2N(C)C1=O
Show InChI InChI=1S/C25H23F3N6O4/c1-5-21(35)30-19-7-6-15(25(26,27)28)8-20(19)31-23-29-12-14-13-34(24(36)33(2)22(14)32-23)16-9-17(37-3)11-18(10-16)38-4/h5-12H,1,13H2,2-4H3,(H,30,35)(H,29,31,32)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


US Patent US9695132 (2017)


BindingDB Entry DOI: 10.7270/Q2TX3CJ7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM91647
PNG
(US9695132, I-53)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(NC4CCCCC4N(C)C(=O)C=C)nc3N(C)C2=O)c1Cl
Show InChI InChI=1S/C25H30Cl2N6O4/c1-6-19(34)31(2)16-10-8-7-9-15(16)29-24-28-12-14-13-33(25(35)32(3)23(14)30-24)22-20(26)17(36-4)11-18(37-5)21(22)27/h6,11-12,15-16H,1,7-10,13H2,2-5H3,(H,28,29,30)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


US Patent US9695132 (2017)


BindingDB Entry DOI: 10.7270/Q2TX3CJ7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM91648
PNG
(US9695132, I-54)
Show SMILES CCN1CCC(CC1)c1ccc(Nc2ncc3CN(C(=O)N(C)c3n2)c2cc(OC)cc(OC)c2)c(NC(=O)C=C)c1
Show InChI InChI=1S/C31H37N7O4/c1-6-28(39)33-27-14-21(20-10-12-37(7-2)13-11-20)8-9-26(27)34-30-32-18-22-19-38(31(40)36(3)29(22)35-30)23-15-24(41-4)17-25(16-23)42-5/h6,8-9,14-18,20H,1,7,10-13,19H2,2-5H3,(H,33,39)(H,32,34,35)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


US Patent US9695132 (2017)


BindingDB Entry DOI: 10.7270/Q2TX3CJ7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM91649
PNG
(US9695132, I-55)
Show SMILES COc1cc(OC)cc(c1)N1Cc2ccc(Nc3ccc(cc3NC(=O)C=C)N3CCN(CC3)C(C)=O)cc2N(C)C1=O
Show InChI InChI=1S/C32H36N6O5/c1-6-31(40)34-29-18-24(37-13-11-36(12-14-37)21(2)39)9-10-28(29)33-23-8-7-22-20-38(32(41)35(3)30(22)15-23)25-16-26(42-4)19-27(17-25)43-5/h6-10,15-19,33H,1,11-14,20H2,2-5H3,(H,34,40)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


US Patent US9695132 (2017)


BindingDB Entry DOI: 10.7270/Q2TX3CJ7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM91650
PNG
(US9695132, I-56)
Show SMILES CCN1CCC(=CC1)c1ccc(Nc2ncc3CN(C(=O)N(C)c3n2)c2cc(OC)cc(OC)c2)c(NC(=O)C=C)c1
Show InChI InChI=1S/C31H35N7O4/c1-6-28(39)33-27-14-21(20-10-12-37(7-2)13-11-20)8-9-26(27)34-30-32-18-22-19-38(31(40)36(3)29(22)35-30)23-15-24(41-4)17-25(16-23)42-5/h6,8-10,14-18H,1,7,11-13,19H2,2-5H3,(H,33,39)(H,32,34,35)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


US Patent US9695132 (2017)


BindingDB Entry DOI: 10.7270/Q2TX3CJ7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM91651
PNG
(US9695132, I-57)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccccc3NC(=O)C=C)nc2N(CCC=C)C1=O
Show InChI InChI=1S/C27H28N6O4/c1-5-7-12-32-25-18(17-33(27(32)35)19-13-20(36-3)15-21(14-19)37-4)16-28-26(31-25)30-23-11-9-8-10-22(23)29-24(34)6-2/h5-6,8-11,13-16H,1-2,7,12,17H2,3-4H3,(H,29,34)(H,28,30,31)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


US Patent US9695132 (2017)


BindingDB Entry DOI: 10.7270/Q2TX3CJ7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM91652
PNG
(US9695132, I-58)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccccc3NC(=O)C=C)nc2N(CCC(O)CO)C1=O
Show InChI InChI=1S/C27H30N6O6/c1-4-24(36)29-22-7-5-6-8-23(22)30-26-28-14-17-15-33(18-11-20(38-2)13-21(12-18)39-3)27(37)32(25(17)31-26)10-9-19(35)16-34/h4-8,11-14,19,34-35H,1,9-10,15-16H2,2-3H3,(H,29,36)(H,28,30,31)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


US Patent US9695132 (2017)


BindingDB Entry DOI: 10.7270/Q2TX3CJ7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM91653
PNG
(US9695132, I-59)
Show SMILES COCCN1C(=O)N(Cc2cnc(Nc3ccccc3NC(=O)C=C)nc12)c1cc(OC)cc(OC)c1
Show InChI InChI=1S/C26H28N6O5/c1-5-23(33)28-21-8-6-7-9-22(21)29-25-27-15-17-16-32(18-12-19(36-3)14-20(13-18)37-4)26(34)31(10-11-35-2)24(17)30-25/h5-9,12-15H,1,10-11,16H2,2-4H3,(H,28,33)(H,27,29,30)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


US Patent US9695132 (2017)


BindingDB Entry DOI: 10.7270/Q2TX3CJ7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM91680
PNG
(US9695132, I-60)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccccc3NC(=O)C=C)nc2N(CC2CCN(CC2)C(=O)OC(C)(C)C)C1=O
Show InChI InChI=1S/C34H41N7O6/c1-7-29(42)36-27-10-8-9-11-28(27)37-31-35-19-23-21-40(24-16-25(45-5)18-26(17-24)46-6)32(43)41(30(23)38-31)20-22-12-14-39(15-13-22)33(44)47-34(2,3)4/h7-11,16-19,22H,1,12-15,20-21H2,2-6H3,(H,36,42)(H,35,37,38)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


US Patent US9695132 (2017)


BindingDB Entry DOI: 10.7270/Q2TX3CJ7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM91681
PNG
(US9695132, I-61)
Show SMILES COCCN1C(=O)N(Cc2cnc(NC3CCCCC3NC(=O)C=C)nc12)c1c(Cl)c(OC)cc(OC)c1Cl
Show InChI InChI=1S/C26H32Cl2N6O5/c1-5-20(35)30-16-8-6-7-9-17(16)31-25-29-13-15-14-34(26(36)33(10-11-37-2)24(15)32-25)23-21(27)18(38-3)12-19(39-4)22(23)28/h5,12-13,16-17H,1,6-11,14H2,2-4H3,(H,30,35)(H,29,31,32)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


US Patent US9695132 (2017)


BindingDB Entry DOI: 10.7270/Q2TX3CJ7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM91682
PNG
(US9695132, I-62)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4ccc(cc4NC(=O)C=C)N4CCC(CC4)C(=O)OC(C)(C)C)nc3N(C)C2=O)c1Cl
Show InChI InChI=1S/C34H39Cl2N7O6/c1-8-26(44)38-23-15-21(42-13-11-19(12-14-42)31(45)49-34(2,3)4)9-10-22(23)39-32-37-17-20-18-43(33(46)41(5)30(20)40-32)29-27(35)24(47-6)16-25(48-7)28(29)36/h8-10,15-17,19H,1,11-14,18H2,2-7H3,(H,38,44)(H,37,39,40)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


US Patent US9695132 (2017)


BindingDB Entry DOI: 10.7270/Q2TX3CJ7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM91858
PNG
(US9695132, I-63)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(NC4CCCCC4NC(=O)C=C)nc3N(Cc3ccccc3)C2=O)c1Cl
Show InChI InChI=1S/C30H32Cl2N6O4/c1-4-24(39)34-20-12-8-9-13-21(20)35-29-33-15-19-17-37(27-25(31)22(41-2)14-23(42-3)26(27)32)30(40)38(28(19)36-29)16-18-10-6-5-7-11-18/h4-7,10-11,14-15,20-21H,1,8-9,12-13,16-17H2,2-3H3,(H,34,39)(H,33,35,36)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
MMDB
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


US Patent US9695132 (2017)


BindingDB Entry DOI: 10.7270/Q2TX3CJ7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM91862
PNG
(US9695132, I-64)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccccc3NC(=O)C=C)nc2N(Cc2cscn2)C1=O
Show InChI InChI=1S/C27H25N7O4S/c1-4-24(35)30-22-7-5-6-8-23(22)31-26-28-12-17-13-33(19-9-20(37-2)11-21(10-19)38-3)27(36)34(25(17)32-26)14-18-15-39-16-29-18/h4-12,15-16H,1,13-14H2,2-3H3,(H,30,35)(H,28,31,32)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


US Patent US9695132 (2017)


BindingDB Entry DOI: 10.7270/Q2TX3CJ7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM88560
PNG
(US9695132, I-2 | US9695132, I-65)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4ccccc4NC(=O)C=C)nc3N(C)C2=O)c1Cl
Show InChI InChI=1S/C24H22Cl2N6O4/c1-5-18(33)28-14-8-6-7-9-15(14)29-23-27-11-13-12-32(24(34)31(2)22(13)30-23)21-19(25)16(35-3)10-17(36-4)20(21)26/h5-11H,1,12H2,2-4H3,(H,28,33)(H,27,29,30)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


US Patent US9695132 (2017)


BindingDB Entry DOI: 10.7270/Q2TX3CJ7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM91868
PNG
(US9695132, I-67)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccccc3NS(=O)(=O)C=C)nc2N(C)C1=O
Show InChI InChI=1S/C23H24N6O5S/c1-5-35(31,32)27-20-9-7-6-8-19(20)25-22-24-13-15-14-29(23(30)28(2)21(15)26-22)16-10-17(33-3)12-18(11-16)34-4/h5-13,27H,1,14H2,2-4H3,(H,24,25,26)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


US Patent US9695132 (2017)


BindingDB Entry DOI: 10.7270/Q2TX3CJ7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM91871
PNG
(US9695132, I-69)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(NC4CCCCC4NC(=O)C=C)nc3N(Cc3cscn3)C2=O)c1Cl
Show InChI InChI=1S/C27H29Cl2N7O4S/c1-4-21(37)32-17-7-5-6-8-18(17)33-26-30-10-15-11-35(24-22(28)19(39-2)9-20(40-3)23(24)29)27(38)36(25(15)34-26)12-16-13-41-14-31-16/h4,9-10,13-14,17-18H,1,5-8,11-12H2,2-3H3,(H,32,37)(H,30,33,34)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


US Patent US9695132 (2017)


BindingDB Entry DOI: 10.7270/Q2TX3CJ7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM91873
PNG
(US9695132, I-70)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(NC4CCCCC4NC(=O)C=C)nc3N(C3CCC3)C2=O)c1Cl
Show InChI InChI=1S/C27H32Cl2N6O4/c1-4-21(36)31-17-10-5-6-11-18(17)32-26-30-13-15-14-34(27(37)35(25(15)33-26)16-8-7-9-16)24-22(28)19(38-2)12-20(39-3)23(24)29/h4,12-13,16-18H,1,5-11,14H2,2-3H3,(H,31,36)(H,30,32,33)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


US Patent US9695132 (2017)


BindingDB Entry DOI: 10.7270/Q2TX3CJ7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM91875
PNG
(US9695132, I-74)
Show SMILES COc1cc(OC)c(Cl)c(N2Cc3cnc(Nc4cc(ccc4NC(=O)C=C)-c4cnn(C)c4)nc3N(C)C2=O)c1Cl
Show InChI InChI=1S/C28H26Cl2N8O4/c1-6-22(39)33-18-8-7-15(16-12-32-36(2)13-16)9-19(18)34-27-31-11-17-14-38(28(40)37(3)26(17)35-27)25-23(29)20(41-4)10-21(42-5)24(25)30/h6-13H,1,14H2,2-5H3,(H,33,39)(H,31,34,35)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


US Patent US9695132 (2017)


BindingDB Entry DOI: 10.7270/Q2TX3CJ7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM91876
PNG
(US9695132, I-75)
Show SMILES COc1cc(OC)c(Cl)c(c1)N1Cc2cnc(Nc3ccccc3NC(=O)C=C)nc2N(C)C1=O
Show InChI InChI=1S/C24H23ClN6O4/c1-5-20(32)27-16-8-6-7-9-17(16)28-23-26-12-14-13-31(24(33)30(2)22(14)29-23)18-10-15(34-3)11-19(35-4)21(18)25/h5-12H,1,13H2,2-4H3,(H,27,32)(H,26,28,29)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


US Patent US9695132 (2017)


BindingDB Entry DOI: 10.7270/Q2TX3CJ7
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM92457
PNG
(US9695132, I-77)
Show SMILES COc1cc(OC)cc(c1)N1Cc2cnc(Nc3ccc(cc3NC(=O)C=C)-c3cnn(C)c3)nc2N(C)C1=O
Show InChI InChI=1S/C28H28N8O4/c1-6-25(37)31-24-9-17(18-14-30-34(2)15-18)7-8-23(24)32-27-29-13-19-16-36(28(38)35(3)26(19)33-27)20-10-21(39-4)12-22(11-20)40-5/h6-15H,1,16H2,2-5H3,(H,31,37)(H,29,32,33)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<100n/an/an/an/an/an/a



Celgene CAR LLC; Sanofi

US Patent


Assay Description
Omnia Assay Protocol for Potency Assessment Against FGFR 4 Enzyme. a) [FGFR4-WT]=10 nM, [ATP]=300 uM, [Y10-Sox]=10 uM (ATP KMapp 300 uM): A 10x stock...


US Patent US9695132 (2017)


BindingDB Entry DOI: 10.7270/Q2TX3CJ7
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 194 total )  |  Next  |  Last  >>
Jump to: