BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 14 hits from Celgene Corporation, Warren, NJ 07059 USA.   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase 4


(Homo sapiens-Homo sapiens (Human)-Homo sapiens (hu...)
BDBM50216304
PNG
(CHEMBL313439)
Show SMILES CCOc1cc(ccc1OC)C(CC#N)N1C(=O)c2ccccc2C1=O
Show InChI InChI=1S/C20H18N2O4/c1-3-26-18-12-13(8-9-17(18)25-2)16(10-11-21)22-19(23)14-6-4-5-7-15(14)20(22)24/h4-9,12,16H,3,10H2,1-2H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 130n/an/an/an/an/an/a



Celgene Corporation, Warren, NJ 07059 USA.

Curated by ChEMBL


Assay Description
Inhibition of PDE4 enzyme from U937 cells


Bioorg Med Chem Lett 8: 2669-74 (1998)


Article DOI: 10.1016/s0960-894x(98)00475-2
More data for this
Ligand-Target Pair
Phosphodiesterase 4


(Homo sapiens-Homo sapiens (Human)-Homo sapiens (hu...)
BDBM50216301
PNG
(CHEMBL88475)
Show SMILES CCOc1cc(ccc1OC)C(CC(=O)OC)N1C(=O)c2ccccc2C1=O
Show InChI InChI=1S/C21H21NO6/c1-4-28-18-11-13(9-10-17(18)26-2)16(12-19(23)27-3)22-20(24)14-7-5-6-8-15(14)21(22)25/h5-11,16H,4,12H2,1-3H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 230n/an/an/an/an/an/a



Celgene Corporation, Warren, NJ 07059 USA.

Curated by ChEMBL


Assay Description
Inhibition of PDE4 enzyme from U937 cells


Bioorg Med Chem Lett 8: 2669-74 (1998)


Article DOI: 10.1016/s0960-894x(98)00475-2
More data for this
Ligand-Target Pair
Phosphodiesterase 4


(Homo sapiens-Homo sapiens (Human)-Homo sapiens (hu...)
BDBM50216299
PNG
(CHEMBL315529)
Show SMILES COc1ccc(cc1OC1CCCC1)C(CC#N)N1C(=O)c2ccccc2C1=O
Show InChI InChI=1S/C23H22N2O4/c1-28-20-11-10-15(14-21(20)29-16-6-2-3-7-16)19(12-13-24)25-22(26)17-8-4-5-9-18(17)23(25)27/h4-5,8-11,14,16,19H,2-3,6-7,12H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 350n/an/an/an/an/an/a



Celgene Corporation, Warren, NJ 07059 USA.

Curated by ChEMBL


Assay Description
Inhibition of PDE4 enzyme from U937 cells


Bioorg Med Chem Lett 8: 2669-74 (1998)


Article DOI: 10.1016/s0960-894x(98)00475-2
More data for this
Ligand-Target Pair
Phosphodiesterase 4


(Homo sapiens-Homo sapiens (Human)-Homo sapiens (hu...)
BDBM14361
PNG
((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Show SMILES COc1ccc(cc1OC1CCCC1)C1CNC(=O)C1
Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
PDB
UniChem

Patents


Similars

PDB
Article
PubMed
n/an/a 400n/an/an/an/an/an/a



Celgene Corporation, Warren, NJ 07059 USA.

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 4 from U937 cells


Bioorg Med Chem Lett 8: 2669-74 (1998)


Article DOI: 10.1016/s0960-894x(98)00475-2
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Phosphodiesterase 4


(Homo sapiens-Homo sapiens (Human)-Homo sapiens (hu...)
BDBM50216303
PNG
(CHEMBL90349)
Show SMILES COC(=O)CC(N1C(=O)c2ccccc2C1=O)c1ccc(OC)c(OC2CC3CCC2C3)c1
Show InChI InChI=1S/C26H27NO6/c1-31-21-10-9-16(13-23(21)33-22-12-15-7-8-17(22)11-15)20(14-24(28)32-2)27-25(29)18-5-3-4-6-19(18)26(27)30/h3-6,9-10,13,15,17,20,22H,7-8,11-12,14H2,1-2H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 740n/an/an/an/an/an/a



Celgene Corporation, Warren, NJ 07059 USA.

Curated by ChEMBL


Assay Description
Inhibition of PDE4 enzyme from U937 cells


Bioorg Med Chem Lett 8: 2669-74 (1998)


Article DOI: 10.1016/s0960-894x(98)00475-2
More data for this
Ligand-Target Pair
Phosphodiesterase 4


(Homo sapiens-Homo sapiens (Human)-Homo sapiens (hu...)
BDBM50216298
PNG
(CC-1088 | CHEMBL88153)
Show SMILES COc1ccc(cc1OC1CCCC1)C(CC(N)=O)N1C(=O)c2ccccc2C1=O
Show InChI InChI=1S/C23H24N2O5/c1-29-19-11-10-14(12-20(19)30-15-6-2-3-7-15)18(13-21(24)26)25-22(27)16-8-4-5-9-17(16)23(25)28/h4-5,8-12,15,18H,2-3,6-7,13H2,1H3,(H2,24,26)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.10E+3n/an/an/an/an/an/a



Celgene Corporation, Warren, NJ 07059 USA.

Curated by ChEMBL


Assay Description
Inhibition of PDE4 enzyme from U937 cells


Bioorg Med Chem Lett 8: 2669-74 (1998)


Article DOI: 10.1016/s0960-894x(98)00475-2
More data for this
Ligand-Target Pair
Phosphodiesterase 4


(Homo sapiens-Homo sapiens (Human)-Homo sapiens (hu...)
BDBM50216295
PNG
(CHEMBL314759)
Show SMILES COc1ccc(cc1OC)C(CC#N)N1C(=O)c2ccccc2C1=O
Show InChI InChI=1S/C19H16N2O4/c1-24-16-8-7-12(11-17(16)25-2)15(9-10-20)21-18(22)13-5-3-4-6-14(13)19(21)23/h3-8,11,15H,9H2,1-2H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.30E+3n/an/an/an/an/an/a



Celgene Corporation, Warren, NJ 07059 USA.

Curated by ChEMBL


Assay Description
Inhibition of PDE4 enzyme from U937 cells


Bioorg Med Chem Lett 8: 2669-74 (1998)


Article DOI: 10.1016/s0960-894x(98)00475-2
More data for this
Ligand-Target Pair
Phosphodiesterase 4


(Homo sapiens-Homo sapiens (Human)-Homo sapiens (hu...)
BDBM50216300
PNG
(CHEMBL90345)
Show SMILES COC(=O)CC(N1C(=O)c2ccccc2C1=O)c1ccc(OC)c(OC2CCCC2)c1
Show InChI InChI=1S/C24H25NO6/c1-29-20-12-11-15(13-21(20)31-16-7-3-4-8-16)19(14-22(26)30-2)25-23(27)17-9-5-6-10-18(17)24(25)28/h5-6,9-13,16,19H,3-4,7-8,14H2,1-2H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.70E+3n/an/an/an/an/an/a



Celgene Corporation, Warren, NJ 07059 USA.

Curated by ChEMBL


Assay Description
Inhibition of PDE4 enzyme from U937 cells


Bioorg Med Chem Lett 8: 2669-74 (1998)


Article DOI: 10.1016/s0960-894x(98)00475-2
More data for this
Ligand-Target Pair
Phosphodiesterase 4


(Homo sapiens-Homo sapiens (Human)-Homo sapiens (hu...)
BDBM50216302
PNG
(CHEMBL419135)
Show SMILES CCOc1cc(ccc1OC)C(CC(N)=O)N1C(=O)c2ccccc2C1=O
Show InChI InChI=1S/C20H20N2O5/c1-3-27-17-10-12(8-9-16(17)26-2)15(11-18(21)23)22-19(24)13-6-4-5-7-14(13)20(22)25/h4-10,15H,3,11H2,1-2H3,(H2,21,23)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.00E+3n/an/an/an/an/an/a



Celgene Corporation, Warren, NJ 07059 USA.

Curated by ChEMBL


Assay Description
Inhibition of PDE4 enzyme from U937 cells


Bioorg Med Chem Lett 8: 2669-74 (1998)


Article DOI: 10.1016/s0960-894x(98)00475-2
More data for this
Ligand-Target Pair
Phosphodiesterase 4


(Homo sapiens-Homo sapiens (Human)-Homo sapiens (hu...)
BDBM50216296
PNG
(CHEMBL89635)
Show SMILES CCOc1cc(ccc1OC)C(CC(=O)OC)N1C(=O)c2c(C1=O)c(F)c(F)c(F)c2F
Show InChI InChI=1S/C21H17F4NO6/c1-4-32-12-7-9(5-6-11(12)30-2)10(8-13(27)31-3)26-20(28)14-15(21(26)29)17(23)19(25)18(24)16(14)22/h5-7,10H,4,8H2,1-3H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.20E+3n/an/an/an/an/an/a



Celgene Corporation, Warren, NJ 07059 USA.

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 4 from U937 cells


Bioorg Med Chem Lett 8: 2669-74 (1998)


Article DOI: 10.1016/s0960-894x(98)00475-2
More data for this
Ligand-Target Pair
Phosphodiesterase 4


(Homo sapiens-Homo sapiens (Human)-Homo sapiens (hu...)
BDBM50052596
PNG
(3-(3,4-Dimethoxy-phenyl)-3-(1,3-dioxo-1,3-dihydro-...)
Show SMILES COC(=O)CC(N1C(=O)c2ccccc2C1=O)c1ccc(OC)c(OC)c1
Show InChI InChI=1S/C20H19NO6/c1-25-16-9-8-12(10-17(16)26-2)15(11-18(22)27-3)21-19(23)13-6-4-5-7-14(13)20(21)24/h4-10,15H,11H2,1-3H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 2.50E+3n/an/an/an/an/an/a



Celgene Corporation, Warren, NJ 07059 USA.

Curated by ChEMBL


Assay Description
Inhibition of PDE4 enzyme from U937 cells


Bioorg Med Chem Lett 8: 2669-74 (1998)


Article DOI: 10.1016/s0960-894x(98)00475-2
More data for this
Ligand-Target Pair
Phosphodiesterase 4


(Homo sapiens-Homo sapiens (Human)-Homo sapiens (hu...)
BDBM50216305
PNG
(CHEMBL275009)
Show SMILES COC(=O)CC(N1C(=O)c2c(C1=O)c(F)c(F)c(F)c2F)c1ccc(OC)c(OC)c1
Show InChI InChI=1S/C20H15F4NO6/c1-29-10-5-4-8(6-11(10)30-2)9(7-12(26)31-3)25-19(27)13-14(20(25)28)16(22)18(24)17(23)15(13)21/h4-6,9H,7H2,1-3H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.70E+3n/an/an/an/an/an/a



Celgene Corporation, Warren, NJ 07059 USA.

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 4 from U937 cells


Bioorg Med Chem Lett 8: 2669-74 (1998)


Article DOI: 10.1016/s0960-894x(98)00475-2
More data for this
Ligand-Target Pair
Phosphodiesterase 4


(Homo sapiens-Homo sapiens (Human)-Homo sapiens (hu...)
BDBM50052599
PNG
(3-(3,4-Dimethoxy-phenyl)-3-(1,3-dioxo-1,3-dihydro-...)
Show SMILES COc1ccc(cc1OC)C(CC(N)=O)N1C(=O)c2ccccc2C1=O
Show InChI InChI=1S/C19H18N2O5/c1-25-15-8-7-11(9-16(15)26-2)14(10-17(20)22)21-18(23)12-5-3-4-6-13(12)19(21)24/h3-9,14H,10H2,1-2H3,(H2,20,22)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 9.40E+3n/an/an/an/an/an/a



Celgene Corporation, Warren, NJ 07059 USA.

Curated by ChEMBL


Assay Description
Inhibition of PDE4 enzyme from U937 cells


Bioorg Med Chem Lett 8: 2669-74 (1998)


Article DOI: 10.1016/s0960-894x(98)00475-2
More data for this
Ligand-Target Pair
Phosphodiesterase 4


(Homo sapiens-Homo sapiens (Human)-Homo sapiens (hu...)
BDBM50070114
PNG
((+/-)-thalidomide | 2-(2,6-Dioxo-piperidin-3-yl)-i...)
Show SMILES O=C1N(C2CCC(=O)NC2=O)C(=O)c2ccccc12
Show InChI InChI=1S/C13H10N2O4/c16-10-6-5-9(11(17)14-10)15-12(18)7-3-1-2-4-8(7)13(15)19/h1-4,9H,5-6H2,(H,14,16,17)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
KEGG
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
n/an/a>5.00E+5n/an/an/an/an/an/a



Celgene Corporation, Warren, NJ 07059 USA.

Curated by ChEMBL


Assay Description
Inhibition of PDE4 enzyme from U937 cells


Bioorg Med Chem Lett 8: 2669-74 (1998)


Article DOI: 10.1016/s0960-894x(98)00475-2
More data for this
Ligand-Target Pair