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Compile Data Set for Download or QSAR

Found 73 hits from Centre de Recherche de Gif   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae (Baker's yeast))
BDBM50067584
PNG
((S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-bip...)
Show SMILES CSCC[C@H](NC(=O)c1ccc(NC[C@@H](N)CS)cc1-c1ccccc1)C(O)=O
Show InChI InChI=1S/C21H27N3O3S2/c1-29-10-9-19(21(26)27)24-20(25)17-8-7-16(23-12-15(22)13-28)11-18(17)14-5-3-2-4-6-14/h2-8,11,15,19,23,28H,9-10,12-13,22H2,1H3,(H,24,25)(H,26,27)/t15-,19+/m1/s1
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n/an/a 0.780n/an/an/an/an/an/a



Centre de Recherche de Gif



Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Farnesyltransferase (FTase)


(Trypanosoma brucei brucei)
BDBM50067584
PNG
((S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-bip...)
Show SMILES CSCC[C@H](NC(=O)c1ccc(NC[C@@H](N)CS)cc1-c1ccccc1)C(O)=O
Show InChI InChI=1S/C21H27N3O3S2/c1-29-10-9-19(21(26)27)24-20(25)17-8-7-16(23-12-15(22)13-28)11-18(17)14-5-3-2-4-6-14/h2-8,11,15,19,23,28H,9-10,12-13,22H2,1H3,(H,24,25)(H,26,27)/t15-,19+/m1/s1
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n/an/a 10n/an/an/an/an/an/a



Centre de Recherche de Gif



Assay Description
Assays were realized on 96-well plates, as described for human FTase with the dansylated peptide Dansyl-GCAIM and the solution contains 15 μL of...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM50067584
PNG
((S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-bip...)
Show SMILES CSCC[C@H](NC(=O)c1ccc(NC[C@@H](N)CS)cc1-c1ccccc1)C(O)=O
Show InChI InChI=1S/C21H27N3O3S2/c1-29-10-9-19(21(26)27)24-20(25)17-8-7-16(23-12-15(22)13-28)11-18(17)14-5-3-2-4-6-14/h2-8,11,15,19,23,28H,9-10,12-13,22H2,1H3,(H,24,25)(H,26,27)/t15-,19+/m1/s1
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n/an/a 15n/an/an/an/an/an/a



Centre de Recherche de Gif



Assay Description
Assays were realized on 96-well plates, as described for yeast FTase but octyl-D-glucopyranoside (0.18%) was used instead of CHAPS and the solution c...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae (Baker's yeast))
BDBM238364
PNG
(3-(4-(Methoxycarbonyl)phenyl)-4-cyano-5-(isopropyl...)
Show SMILES COC(=O)c1ccc(cc1)-c1c(sc(SC(C)C)c1C#N)C(O)=O
Show InChI InChI=1S/C17H15NO4S2/c1-9(2)23-17-12(8-18)13(14(24-17)15(19)20)10-4-6-11(7-5-10)16(21)22-3/h4-7,9H,1-3H3,(H,19,20)
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n/an/a 85n/an/an/an/an/an/a



Centre de Recherche de Gif



Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae (Baker's yeast))
BDBM238353
PNG
(3-(4-Chlorophenyl)-4-cyano-5-(isopropylthio)thioph...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccc(Cl)cc1
Show InChI InChI=1S/C15H12ClNO2S2/c1-8(2)20-15-11(7-17)12(13(21-15)14(18)19)9-3-5-10(16)6-4-9/h3-6,8H,1-2H3,(H,18,19)
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n/an/a 110n/an/an/an/an/an/a



Centre de Recherche de Gif



Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae (Baker's yeast))
BDBM238367
PNG
(3-(4-Tolyl)-4-cyano-5-(isopropylthio)thiophene-2-c...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccc(C)cc1
Show InChI InChI=1S/C16H15NO2S2/c1-9(2)20-16-12(8-17)13(14(21-16)15(18)19)11-6-4-10(3)5-7-11/h4-7,9H,1-3H3,(H,18,19)
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n/an/a 190n/an/an/an/an/an/a



Centre de Recherche de Gif



Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae (Baker's yeast))
BDBM238361
PNG
(3-(4-Methoxyphenyl)-4-cyano-5-(isopropylthio)thiop...)
Show SMILES COc1ccc(cc1)-c1c(sc(SC(C)C)c1C#N)C(O)=O
Show InChI InChI=1S/C16H15NO3S2/c1-9(2)21-16-12(8-17)13(14(22-16)15(18)19)10-4-6-11(20-3)7-5-10/h4-7,9H,1-3H3,(H,18,19)
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n/an/a 250n/an/an/an/an/an/a



Centre de Recherche de Gif



Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae (Baker's yeast))
BDBM238356
PNG
(3-(4-Fluorophenyl)-4-cyano-5-(isopropylthio)thioph...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccc(F)cc1
Show InChI InChI=1S/C15H12FNO2S2/c1-8(2)20-15-11(7-17)12(13(21-15)14(18)19)9-3-5-10(16)6-4-9/h3-6,8H,1-2H3,(H,18,19)
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n/an/a 270n/an/an/an/an/an/a



Centre de Recherche de Gif



Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae (Baker's yeast))
BDBM238371
PNG
(3-(2-Naphthyl)-4-cyano-5-(isopropylthio)thiophene-...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccc2ccccc2c1
Show InChI InChI=1S/C19H15NO2S2/c1-11(2)23-19-15(10-20)16(17(24-19)18(21)22)14-8-7-12-5-3-4-6-13(12)9-14/h3-9,11H,1-2H3,(H,21,22)
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n/an/a 320n/an/an/an/an/an/a



Centre de Recherche de Gif



Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae (Baker's yeast))
BDBM238374
PNG
(3-(3-Thienyl)-4-cyano-5-(isopropylthio)thiophene-2...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(Sc2ccsc2)c1C#N
Show InChI InChI=1S/C13H11NO2S4/c1-7(2)18-13-9(5-14)10(11(20-13)12(15)16)19-8-3-4-17-6-8/h3-4,6-7H,1-2H3,(H,15,16)
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n/an/a 350n/an/an/an/an/an/a



Centre de Recherche de Gif



Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae (Baker's yeast))
BDBM238357
PNG
(3-(3-Fluorophenyl)-4-cyano-5-(isopropylthio)thioph...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1cccc(F)c1
Show InChI InChI=1S/C15H12FNO2S2/c1-8(2)20-15-11(7-17)12(13(21-15)14(18)19)9-4-3-5-10(16)6-9/h3-6,8H,1-2H3,(H,18,19)
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n/an/a 460n/an/an/an/an/an/a



Centre de Recherche de Gif



Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae (Baker's yeast))
BDBM238359
PNG
(3-(4-(Trifluoromethyl)phenyl)-4-cyano-5-(isopropyl...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C16H12F3NO2S2/c1-8(2)23-15-11(7-20)12(13(24-15)14(21)22)9-3-5-10(6-4-9)16(17,18)19/h3-6,8H,1-2H3,(H,21,22)
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n/an/a 580n/an/an/an/an/an/a



Centre de Recherche de Gif



Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae (Baker's yeast))
BDBM238366
PNG
(3-Phenyl-4-cyano-5-(isopropylthio)thiophene-2-carb...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccccc1
Show InChI InChI=1S/C15H13NO2S2/c1-9(2)19-15-11(8-16)12(13(20-15)14(17)18)10-6-4-3-5-7-10/h3-7,9H,1-2H3,(H,17,18)
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UniProtKB/SwissProt

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n/an/a 610n/an/an/an/an/an/a



Centre de Recherche de Gif



Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae (Baker's yeast))
BDBM238365
PNG
(3-(3-(Methoxycarbonyl)phenyl)-4-cyano-5-(isopropyl...)
Show SMILES COC(=O)c1cccc(c1)-c1c(sc(SC(C)C)c1C#N)C(O)=O
Show InChI InChI=1S/C17H15NO4S2/c1-9(2)23-17-12(8-18)13(14(24-17)15(19)20)10-5-4-6-11(7-10)16(21)22-3/h4-7,9H,1-3H3,(H,19,20)
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n/an/a 620n/an/an/an/an/an/a



Centre de Recherche de Gif



Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae (Baker's yeast))
BDBM238373
PNG
(3-(3-Biphenyl)-4-cyano-5-(isopropylthio)thiophene-...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C21H17NO2S2/c1-13(2)25-21-17(12-22)18(19(26-21)20(23)24)16-10-6-9-15(11-16)14-7-4-3-5-8-14/h3-11,13H,1-2H3,(H,23,24)
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n/an/a 640n/an/an/an/an/an/a



Centre de Recherche de Gif



Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae (Baker's yeast))
BDBM238375
PNG
(3-(1-Dibenzofuranyl)-4-cyano-5-(isopropylthio)thio...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1cccc2oc3ccccc3c12
Show InChI InChI=1S/C21H15NO3S2/c1-11(2)26-21-14(10-22)18(19(27-21)20(23)24)13-7-5-9-16-17(13)12-6-3-4-8-15(12)25-16/h3-9,11H,1-2H3,(H,23,24)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Centre de Recherche de Gif



Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae (Baker's yeast))
BDBM238370
PNG
(3-(1-Naphthyl)-4-cyano-5-(isopropylthio)thiophene-...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1cccc2ccccc12
Show InChI InChI=1S/C19H15NO2S2/c1-11(2)23-19-15(10-20)16(17(24-19)18(21)22)14-9-5-7-12-6-3-4-8-13(12)14/h3-9,11H,1-2H3,(H,21,22)
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n/an/a 1.10E+3n/an/an/an/an/an/a



Centre de Recherche de Gif



Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae (Baker's yeast))
BDBM238354
PNG
(3-(3-Chlorophenyl)-4-cyano-5-(isopropylthio)thioph...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1cccc(Cl)c1
Show InChI InChI=1S/C15H12ClNO2S2/c1-8(2)20-15-11(7-17)12(13(21-15)14(18)19)9-4-3-5-10(16)6-9/h3-6,8H,1-2H3,(H,18,19)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Centre de Recherche de Gif



Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae (Baker's yeast))
BDBM238358
PNG
(3-(2-Fluorophenyl)-4-cyano-5-(isopropylthio)thioph...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccccc1F
Show InChI InChI=1S/C15H12FNO2S2/c1-8(2)20-15-10(7-17)12(13(21-15)14(18)19)9-5-3-4-6-11(9)16/h3-6,8H,1-2H3,(H,18,19)
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UniChem
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n/an/a 1.30E+3n/an/an/an/an/an/a



Centre de Recherche de Gif



Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae (Baker's yeast))
BDBM238368
PNG
(3-(3-Tolyl)-4-cyano-5-(isopropylthio)thiophene-2-c...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1cccc(C)c1
Show InChI InChI=1S/C16H15NO2S2/c1-9(2)20-16-12(8-17)13(14(21-16)15(18)19)11-6-4-5-10(3)7-11/h4-7,9H,1-3H3,(H,18,19)
KEGG

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n/an/a 1.40E+3n/an/an/an/an/an/a



Centre de Recherche de Gif



Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae (Baker's yeast))
BDBM238355
PNG
(3-(2-Chlorophenyl)-4-cyano-5-(isopropylthio)thioph...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccccc1Cl
Show InChI InChI=1S/C15H12ClNO2S2/c1-8(2)20-15-10(7-17)12(13(21-15)14(18)19)9-5-3-4-6-11(9)16/h3-6,8H,1-2H3,(H,18,19)
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Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae (Baker's yeast))
BDBM238360
PNG
(3-(3-(Trifluoromethyl)phenyl)-4-cyano-5-(isopropyl...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C16H12F3NO2S2/c1-8(2)23-15-11(7-20)12(13(24-15)14(21)22)9-4-3-5-10(6-9)16(17,18)19/h3-6,8H,1-2H3,(H,21,22)
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Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae (Baker's yeast))
BDBM238362
PNG
(3-(3-Methoxyphenyl)-4-cyano-5-(isopropylthio)thiop...)
Show SMILES COc1cccc(c1)-c1c(sc(SC(C)C)c1C#N)C(O)=O
Show InChI InChI=1S/C16H15NO3S2/c1-9(2)21-16-12(8-17)13(14(22-16)15(18)19)10-5-4-6-11(7-10)20-3/h4-7,9H,1-3H3,(H,18,19)
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Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae (Baker's yeast))
BDBM238372
PNG
(3-(4-Biphenyl)-4-cyano-5-(isopropylthio)thiophene-...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C21H17NO2S2/c1-13(2)25-21-17(12-22)18(19(26-21)20(23)24)16-10-8-15(9-11-16)14-6-4-3-5-7-14/h3-11,13H,1-2H3,(H,23,24)
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Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae (Baker's yeast))
BDBM238369
PNG
(3-(2-Tolyl)-4-cyano-5-(isopropylthio)thiophene-2-c...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccccc1C
Show InChI InChI=1S/C16H15NO2S2/c1-9(2)20-16-12(8-17)13(14(21-16)15(18)19)11-7-5-4-6-10(11)3/h4-7,9H,1-3H3,(H,18,19)
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Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM238373
PNG
(3-(3-Biphenyl)-4-cyano-5-(isopropylthio)thiophene-...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C21H17NO2S2/c1-13(2)25-21-17(12-22)18(19(26-21)20(23)24)16-10-6-9-15(11-16)14-7-4-3-5-8-14/h3-11,13H,1-2H3,(H,23,24)
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Assay Description
Assays were realized on 96-well plates, as described for yeast FTase but octyl-D-glucopyranoside (0.18%) was used instead of CHAPS and the solution c...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Farnesyltransferase (FTase)


(Trypanosoma brucei brucei)
BDBM238375
PNG
(3-(1-Dibenzofuranyl)-4-cyano-5-(isopropylthio)thio...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1cccc2oc3ccccc3c12
Show InChI InChI=1S/C21H15NO3S2/c1-11(2)26-21-14(10-22)18(19(27-21)20(23)24)13-7-5-9-16-17(13)12-6-3-4-8-15(12)25-16/h3-9,11H,1-2H3,(H,23,24)
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Assay Description
Assays were realized on 96-well plates, as described for human FTase with the dansylated peptide Dansyl-GCAIM and the solution contains 15 μL of...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM238371
PNG
(3-(2-Naphthyl)-4-cyano-5-(isopropylthio)thiophene-...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccc2ccccc2c1
Show InChI InChI=1S/C19H15NO2S2/c1-11(2)23-19-15(10-20)16(17(24-19)18(21)22)14-8-7-12-5-3-4-6-13(12)9-14/h3-9,11H,1-2H3,(H,21,22)
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Assay Description
Assays were realized on 96-well plates, as described for yeast FTase but octyl-D-glucopyranoside (0.18%) was used instead of CHAPS and the solution c...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Farnesyltransferase (FTase)


(Trypanosoma brucei brucei)
BDBM238373
PNG
(3-(3-Biphenyl)-4-cyano-5-(isopropylthio)thiophene-...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C21H17NO2S2/c1-13(2)25-21-17(12-22)18(19(26-21)20(23)24)16-10-6-9-15(11-16)14-7-4-3-5-8-14/h3-11,13H,1-2H3,(H,23,24)
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Assay Description
Assays were realized on 96-well plates, as described for human FTase with the dansylated peptide Dansyl-GCAIM and the solution contains 15 μL of...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM238372
PNG
(3-(4-Biphenyl)-4-cyano-5-(isopropylthio)thiophene-...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C21H17NO2S2/c1-13(2)25-21-17(12-22)18(19(26-21)20(23)24)16-10-8-15(9-11-16)14-6-4-3-5-7-14/h3-11,13H,1-2H3,(H,23,24)
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Assay Description
Assays were realized on 96-well plates, as described for yeast FTase but octyl-D-glucopyranoside (0.18%) was used instead of CHAPS and the solution c...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Farnesyltransferase (FTase)


(Trypanosoma brucei brucei)
BDBM238365
PNG
(3-(3-(Methoxycarbonyl)phenyl)-4-cyano-5-(isopropyl...)
Show SMILES COC(=O)c1cccc(c1)-c1c(sc(SC(C)C)c1C#N)C(O)=O
Show InChI InChI=1S/C17H15NO4S2/c1-9(2)23-17-12(8-18)13(14(24-17)15(19)20)10-5-4-6-11(7-10)16(21)22-3/h4-7,9H,1-3H3,(H,19,20)
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Assay Description
Assays were realized on 96-well plates, as described for human FTase with the dansylated peptide Dansyl-GCAIM and the solution contains 15 μL of...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM238365
PNG
(3-(3-(Methoxycarbonyl)phenyl)-4-cyano-5-(isopropyl...)
Show SMILES COC(=O)c1cccc(c1)-c1c(sc(SC(C)C)c1C#N)C(O)=O
Show InChI InChI=1S/C17H15NO4S2/c1-9(2)23-17-12(8-18)13(14(24-17)15(19)20)10-5-4-6-11(7-10)16(21)22-3/h4-7,9H,1-3H3,(H,19,20)
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Assay Description
Assays were realized on 96-well plates, as described for yeast FTase but octyl-D-glucopyranoside (0.18%) was used instead of CHAPS and the solution c...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Farnesyltransferase (FTase)


(Trypanosoma brucei brucei)
BDBM238361
PNG
(3-(4-Methoxyphenyl)-4-cyano-5-(isopropylthio)thiop...)
Show SMILES COc1ccc(cc1)-c1c(sc(SC(C)C)c1C#N)C(O)=O
Show InChI InChI=1S/C16H15NO3S2/c1-9(2)21-16-12(8-17)13(14(22-16)15(18)19)10-4-6-11(20-3)7-5-10/h4-7,9H,1-3H3,(H,18,19)
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Assay Description
Assays were realized on 96-well plates, as described for human FTase with the dansylated peptide Dansyl-GCAIM and the solution contains 15 μL of...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Farnesyltransferase (FTase)


(Trypanosoma brucei brucei)
BDBM238371
PNG
(3-(2-Naphthyl)-4-cyano-5-(isopropylthio)thiophene-...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccc2ccccc2c1
Show InChI InChI=1S/C19H15NO2S2/c1-11(2)23-19-15(10-20)16(17(24-19)18(21)22)14-8-7-12-5-3-4-6-13(12)9-14/h3-9,11H,1-2H3,(H,21,22)
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Assay Description
Assays were realized on 96-well plates, as described for human FTase with the dansylated peptide Dansyl-GCAIM and the solution contains 15 μL of...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit


(Saccharomyces cerevisiae (Baker's yeast))
BDBM238363
PNG
(3-(2-Methoxyphenyl)-4-cyano-5-(isopropylthio)thiop...)
Show SMILES COc1ccccc1-c1c(sc(SC(C)C)c1C#N)C(O)=O
Show InChI InChI=1S/C16H15NO3S2/c1-9(2)21-16-11(8-17)13(14(22-16)15(18)19)10-6-4-5-7-12(10)20-3/h4-7,9H,1-3H3,(H,18,19)
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Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Farnesyltransferase (FTase)


(Trypanosoma brucei brucei)
BDBM238370
PNG
(3-(1-Naphthyl)-4-cyano-5-(isopropylthio)thiophene-...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1cccc2ccccc12
Show InChI InChI=1S/C19H15NO2S2/c1-11(2)23-19-15(10-20)16(17(24-19)18(21)22)14-9-5-7-12-6-3-4-8-13(12)14/h3-9,11H,1-2H3,(H,21,22)
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Assay Description
Assays were realized on 96-well plates, as described for human FTase with the dansylated peptide Dansyl-GCAIM and the solution contains 15 μL of...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Farnesyltransferase (FTase)


(Trypanosoma brucei brucei)
BDBM238353
PNG
(3-(4-Chlorophenyl)-4-cyano-5-(isopropylthio)thioph...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccc(Cl)cc1
Show InChI InChI=1S/C15H12ClNO2S2/c1-8(2)20-15-11(7-17)12(13(21-15)14(18)19)9-3-5-10(16)6-4-9/h3-6,8H,1-2H3,(H,18,19)
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Assay Description
Assays were realized on 96-well plates, as described for human FTase with the dansylated peptide Dansyl-GCAIM and the solution contains 15 μL of...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM238364
PNG
(3-(4-(Methoxycarbonyl)phenyl)-4-cyano-5-(isopropyl...)
Show SMILES COC(=O)c1ccc(cc1)-c1c(sc(SC(C)C)c1C#N)C(O)=O
Show InChI InChI=1S/C17H15NO4S2/c1-9(2)23-17-12(8-18)13(14(24-17)15(19)20)10-4-6-11(7-5-10)16(21)22-3/h4-7,9H,1-3H3,(H,19,20)
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Assay Description
Assays were realized on 96-well plates, as described for yeast FTase but octyl-D-glucopyranoside (0.18%) was used instead of CHAPS and the solution c...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Farnesyltransferase (FTase)


(Trypanosoma brucei brucei)
BDBM238364
PNG
(3-(4-(Methoxycarbonyl)phenyl)-4-cyano-5-(isopropyl...)
Show SMILES COC(=O)c1ccc(cc1)-c1c(sc(SC(C)C)c1C#N)C(O)=O
Show InChI InChI=1S/C17H15NO4S2/c1-9(2)23-17-12(8-18)13(14(24-17)15(19)20)10-4-6-11(7-5-10)16(21)22-3/h4-7,9H,1-3H3,(H,19,20)
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Assay Description
Assays were realized on 96-well plates, as described for human FTase with the dansylated peptide Dansyl-GCAIM and the solution contains 15 μL of...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Farnesyltransferase (FTase)


(Trypanosoma brucei brucei)
BDBM238354
PNG
(3-(3-Chlorophenyl)-4-cyano-5-(isopropylthio)thioph...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1cccc(Cl)c1
Show InChI InChI=1S/C15H12ClNO2S2/c1-8(2)20-15-11(7-17)12(13(21-15)14(18)19)9-4-3-5-10(16)6-9/h3-6,8H,1-2H3,(H,18,19)
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Assay Description
Assays were realized on 96-well plates, as described for human FTase with the dansylated peptide Dansyl-GCAIM and the solution contains 15 μL of...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM238375
PNG
(3-(1-Dibenzofuranyl)-4-cyano-5-(isopropylthio)thio...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1cccc2oc3ccccc3c12
Show InChI InChI=1S/C21H15NO3S2/c1-11(2)26-21-14(10-22)18(19(27-21)20(23)24)13-7-5-9-16-17(13)12-6-3-4-8-15(12)25-16/h3-9,11H,1-2H3,(H,23,24)
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n/an/a 1.50E+4n/an/an/an/an/an/a



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Assay Description
Assays were realized on 96-well plates, as described for yeast FTase but octyl-D-glucopyranoside (0.18%) was used instead of CHAPS and the solution c...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM238353
PNG
(3-(4-Chlorophenyl)-4-cyano-5-(isopropylthio)thioph...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccc(Cl)cc1
Show InChI InChI=1S/C15H12ClNO2S2/c1-8(2)20-15-11(7-17)12(13(21-15)14(18)19)9-3-5-10(16)6-4-9/h3-6,8H,1-2H3,(H,18,19)
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n/an/a 1.60E+4n/an/an/an/an/an/a



Centre de Recherche de Gif



Assay Description
Assays were realized on 96-well plates, as described for yeast FTase but octyl-D-glucopyranoside (0.18%) was used instead of CHAPS and the solution c...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM238368
PNG
(3-(3-Tolyl)-4-cyano-5-(isopropylthio)thiophene-2-c...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1cccc(C)c1
Show InChI InChI=1S/C16H15NO2S2/c1-9(2)20-16-12(8-17)13(14(21-16)15(18)19)11-6-4-5-10(3)7-11/h4-7,9H,1-3H3,(H,18,19)
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n/an/a 1.60E+4n/an/an/an/an/an/a



Centre de Recherche de Gif



Assay Description
Assays were realized on 96-well plates, as described for yeast FTase but octyl-D-glucopyranoside (0.18%) was used instead of CHAPS and the solution c...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Farnesyltransferase (FTase)


(Trypanosoma brucei brucei)
BDBM238367
PNG
(3-(4-Tolyl)-4-cyano-5-(isopropylthio)thiophene-2-c...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccc(C)cc1
Show InChI InChI=1S/C16H15NO2S2/c1-9(2)20-16-12(8-17)13(14(21-16)15(18)19)11-6-4-10(3)5-7-11/h4-7,9H,1-3H3,(H,18,19)
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n/an/a 1.70E+4n/an/an/an/an/an/a



Centre de Recherche de Gif



Assay Description
Assays were realized on 96-well plates, as described for human FTase with the dansylated peptide Dansyl-GCAIM and the solution contains 15 μL of...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Farnesyltransferase (FTase)


(Trypanosoma brucei brucei)
BDBM238362
PNG
(3-(3-Methoxyphenyl)-4-cyano-5-(isopropylthio)thiop...)
Show SMILES COc1cccc(c1)-c1c(sc(SC(C)C)c1C#N)C(O)=O
Show InChI InChI=1S/C16H15NO3S2/c1-9(2)21-16-12(8-17)13(14(22-16)15(18)19)10-5-4-6-11(7-10)20-3/h4-7,9H,1-3H3,(H,18,19)
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n/an/a 1.80E+4n/an/an/an/an/an/a



Centre de Recherche de Gif



Assay Description
Assays were realized on 96-well plates, as described for human FTase with the dansylated peptide Dansyl-GCAIM and the solution contains 15 μL of...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Farnesyltransferase (FTase)


(Trypanosoma brucei brucei)
BDBM238360
PNG
(3-(3-(Trifluoromethyl)phenyl)-4-cyano-5-(isopropyl...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C16H12F3NO2S2/c1-8(2)23-15-11(7-20)12(13(24-15)14(21)22)9-4-3-5-10(6-9)16(17,18)19/h3-6,8H,1-2H3,(H,21,22)
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n/an/a 1.90E+4n/an/an/an/an/an/a



Centre de Recherche de Gif



Assay Description
Assays were realized on 96-well plates, as described for human FTase with the dansylated peptide Dansyl-GCAIM and the solution contains 15 μL of...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM238356
PNG
(3-(4-Fluorophenyl)-4-cyano-5-(isopropylthio)thioph...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccc(F)cc1
Show InChI InChI=1S/C15H12FNO2S2/c1-8(2)20-15-11(7-17)12(13(21-15)14(18)19)9-3-5-10(16)6-4-9/h3-6,8H,1-2H3,(H,18,19)
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n/an/a 2.00E+4n/an/an/an/an/an/a



Centre de Recherche de Gif



Assay Description
Assays were realized on 96-well plates, as described for yeast FTase but octyl-D-glucopyranoside (0.18%) was used instead of CHAPS and the solution c...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM238367
PNG
(3-(4-Tolyl)-4-cyano-5-(isopropylthio)thiophene-2-c...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccc(C)cc1
Show InChI InChI=1S/C16H15NO2S2/c1-9(2)20-16-12(8-17)13(14(21-16)15(18)19)11-6-4-10(3)5-7-11/h4-7,9H,1-3H3,(H,18,19)
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n/an/a 2.10E+4n/an/an/an/an/an/a



Centre de Recherche de Gif



Assay Description
Assays were realized on 96-well plates, as described for yeast FTase but octyl-D-glucopyranoside (0.18%) was used instead of CHAPS and the solution c...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (human))
BDBM238357
PNG
(3-(3-Fluorophenyl)-4-cyano-5-(isopropylthio)thioph...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1cccc(F)c1
Show InChI InChI=1S/C15H12FNO2S2/c1-8(2)20-15-11(7-17)12(13(21-15)14(18)19)9-4-3-5-10(16)6-9/h3-6,8H,1-2H3,(H,18,19)
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n/an/a 2.30E+4n/an/an/an/an/an/a



Centre de Recherche de Gif



Assay Description
Assays were realized on 96-well plates, as described for yeast FTase but octyl-D-glucopyranoside (0.18%) was used instead of CHAPS and the solution c...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Farnesyltransferase (FTase)


(Trypanosoma brucei brucei)
BDBM238374
PNG
(3-(3-Thienyl)-4-cyano-5-(isopropylthio)thiophene-2...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(Sc2ccsc2)c1C#N
Show InChI InChI=1S/C13H11NO2S4/c1-7(2)18-13-9(5-14)10(11(20-13)12(15)16)19-8-3-4-17-6-8/h3-4,6-7H,1-2H3,(H,15,16)
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n/an/a 2.60E+4n/an/an/an/an/an/a



Centre de Recherche de Gif



Assay Description
Assays were realized on 96-well plates, as described for human FTase with the dansylated peptide Dansyl-GCAIM and the solution contains 15 μL of...


J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
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