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Compile Data Set for Download or QSAR

Found 46 hits from Cephalon, Inc   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50136008
PNG
(12-(3-hydroxypropyl)-9-isopropoxymethyl-6,7,12,13-...)
Show SMILES CC(C)OCc1ccc2n(CCCO)c3c4Cc5ccccc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C28H28N2O3/c1-16(2)33-15-17-8-9-23-20(12-17)25-22-14-29-28(32)26(22)24-19-7-4-3-6-18(19)13-21(24)27(25)30(23)10-5-11-31/h3-4,6-9,12,16,31H,5,10-11,13-15H2,1-2H3,(H,29,32)
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n/an/a 1.60n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of Tyrosine-protein kinase receptor FLT3 (fms-related tyrosine kinase 3) receptor


J Med Chem 46: 5375-88 (2003)


Article DOI: 10.1021/jm0301641
BindingDB Entry DOI: 10.7270/Q2V69J1X
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM50136008
PNG
(12-(3-hydroxypropyl)-9-isopropoxymethyl-6,7,12,13-...)
Show SMILES CC(C)OCc1ccc2n(CCCO)c3c4Cc5ccccc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C28H28N2O3/c1-16(2)33-15-17-8-9-23-20(12-17)25-22-14-29-28(32)26(22)24-19-7-4-3-6-18(19)13-21(24)27(25)30(23)10-5-11-31/h3-4,6-9,12,16,31H,5,10-11,13-15H2,1-2H3,(H,29,32)
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n/an/a 4n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of Vascular endothelial growth factor receptor 3


J Med Chem 46: 5375-88 (2003)


Article DOI: 10.1021/jm0301641
BindingDB Entry DOI: 10.7270/Q2V69J1X
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50136019
PNG
(9-ethoxymethyl-12-(3-hydroxypropyl)-6,7,12,13-tetr...)
Show SMILES CCOCc1ccc2n(CCCO)c3c4Cc5ccccc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C27H26N2O3/c1-2-32-15-16-8-9-22-19(12-16)24-21-14-28-27(31)25(21)23-18-7-4-3-6-17(18)13-20(23)26(24)29(22)10-5-11-30/h3-4,6-9,12,30H,2,5,10-11,13-15H2,1H3,(H,28,31)
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n/an/a 4n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of human Vascular endothelial growth factor receptor 2


J Med Chem 46: 5375-88 (2003)


Article DOI: 10.1021/jm0301641
BindingDB Entry DOI: 10.7270/Q2V69J1X
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50136008
PNG
(12-(3-hydroxypropyl)-9-isopropoxymethyl-6,7,12,13-...)
Show SMILES CC(C)OCc1ccc2n(CCCO)c3c4Cc5ccccc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C28H28N2O3/c1-16(2)33-15-17-8-9-23-20(12-17)25-22-14-29-28(32)26(22)24-19-7-4-3-6-18(19)13-21(24)27(25)30(23)10-5-11-31/h3-4,6-9,12,16,31H,5,10-11,13-15H2,1-2H3,(H,29,32)
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n/an/a 8n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of human Vascular endothelial growth factor receptor 2


J Med Chem 46: 5375-88 (2003)


Article DOI: 10.1021/jm0301641
BindingDB Entry DOI: 10.7270/Q2V69J1X
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50136018
PNG
(9-(tert-butoxymethyl)-12-(3-hydroxypropyl)-6,7,12,...)
Show SMILES CC(C)(C)OCc1ccc2n(CCCO)c3c4Cc5ccccc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C29H30N2O3/c1-29(2,3)34-16-17-9-10-23-20(13-17)25-22-15-30-28(33)26(22)24-19-8-5-4-7-18(19)14-21(24)27(25)31(23)11-6-12-32/h4-5,7-10,13,32H,6,11-12,14-16H2,1-3H3,(H,30,33)
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n/an/a 11n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of human Vascular endothelial growth factor receptor 2


J Med Chem 46: 5375-88 (2003)


Article DOI: 10.1021/jm0301641
BindingDB Entry DOI: 10.7270/Q2V69J1X
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50024274
PNG
(CHEMBL2448133)
Show SMILES CC[C@@H](C)OCc1ccc2n(CCCO)c3c4Cc5ccccc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C29H30N2O3/c1-3-17(2)34-16-18-9-10-24-21(13-18)26-23-15-30-29(33)27(23)25-20-8-5-4-7-19(20)14-22(25)28(26)31(24)11-6-12-32/h4-5,7-10,13,17,32H,3,6,11-12,14-16H2,1-2H3,(H,30,33)/t17-/m1/s1
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n/an/a 12n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against human vascular endothelial growth factor receptor 2


J Med Chem 46: 5375-88 (2003)


Article DOI: 10.1021/jm0301641
BindingDB Entry DOI: 10.7270/Q2V69J1X
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50136013
PNG
(9-(sec-butoxymethyl)-12-(3-hydroxypropyl)-6,7,12,1...)
Show SMILES CCC(C)OCc1ccc2n(CCCO)c3c4Cc5ccccc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C29H30N2O3/c1-3-17(2)34-16-18-9-10-24-21(13-18)26-23-15-30-29(33)27(23)25-20-8-5-4-7-19(20)14-22(25)28(26)31(24)11-6-12-32/h4-5,7-10,13,17,32H,3,6,11-12,14-16H2,1-2H3,(H,30,33)
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n/an/a 12n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of human Vascular endothelial growth factor receptor 2


J Med Chem 46: 5375-88 (2003)


Article DOI: 10.1021/jm0301641
BindingDB Entry DOI: 10.7270/Q2V69J1X
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50136021
PNG
(12-(3-hydroxypropyl)-9-propoxymethyl-6,7,12,13-tet...)
Show SMILES CCCOCc1ccc2n(CCCO)c3c4Cc5ccccc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C28H28N2O3/c1-2-12-33-16-17-8-9-23-20(13-17)25-22-15-29-28(32)26(22)24-19-7-4-3-6-18(19)14-21(24)27(25)30(23)10-5-11-31/h3-4,6-9,13,31H,2,5,10-12,14-16H2,1H3,(H,29,32)
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n/an/a 13n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of human Vascular endothelial growth factor receptor 2


J Med Chem 46: 5375-88 (2003)


Article DOI: 10.1021/jm0301641
BindingDB Entry DOI: 10.7270/Q2V69J1X
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM50136008
PNG
(12-(3-hydroxypropyl)-9-isopropoxymethyl-6,7,12,13-...)
Show SMILES CC(C)OCc1ccc2n(CCCO)c3c4Cc5ccccc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C28H28N2O3/c1-16(2)33-15-17-8-9-23-20(12-17)25-22-14-29-28(32)26(22)24-19-7-4-3-6-18(19)13-21(24)27(25)30(23)10-5-11-31/h3-4,6-9,12,16,31H,5,10-11,13-15H2,1-2H3,(H,29,32)
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n/an/a 16n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of Vascular endothelial growth factor receptor 1


J Med Chem 46: 5375-88 (2003)


Article DOI: 10.1021/jm0301641
BindingDB Entry DOI: 10.7270/Q2V69J1X
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50136017
PNG
(12-(3-hydroxypropyl)-9-methoxymethyl-6,7,12,13-tet...)
Show SMILES COCc1ccc2n(CCCO)c3c4Cc5ccccc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C26H24N2O3/c1-31-14-15-7-8-21-18(11-15)23-20-13-27-26(30)24(20)22-17-6-3-2-5-16(17)12-19(22)25(23)28(21)9-4-10-29/h2-3,5-8,11,29H,4,9-10,12-14H2,1H3,(H,27,30)
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n/an/a 17n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of human Vascular endothelial growth factor receptor 2


J Med Chem 46: 5375-88 (2003)


Article DOI: 10.1021/jm0301641
BindingDB Entry DOI: 10.7270/Q2V69J1X
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50136024
PNG
(3-(9-isopropoxymethyl-5-oxo-6,7,12,13-tetrahydro-5...)
Show SMILES CC(C)OCc1ccc2n(CCCOC(=O)CN(C)C)c3c4Cc5ccccc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C32H35N3O4/c1-19(2)39-18-20-10-11-26-23(14-20)29-25-16-33-32(37)30(25)28-22-9-6-5-8-21(22)15-24(28)31(29)35(26)12-7-13-38-27(36)17-34(3)4/h5-6,8-11,14,19H,7,12-13,15-18H2,1-4H3,(H,33,37)
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n/an/a 18n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of human Vascular endothelial growth factor receptor 2


J Med Chem 46: 5375-88 (2003)


Article DOI: 10.1021/jm0301641
BindingDB Entry DOI: 10.7270/Q2V69J1X
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50136015
PNG
(9-butoxymethyl-12-(3-hydroxypropyl)-6,7,12,13-tetr...)
Show SMILES CCCCOCc1ccc2n(CCCO)c3c4Cc5ccccc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C29H30N2O3/c1-2-3-13-34-17-18-9-10-24-21(14-18)26-23-16-30-29(33)27(23)25-20-8-5-4-7-19(20)15-22(25)28(26)31(24)11-6-12-32/h4-5,7-10,14,32H,2-3,6,11-13,15-17H2,1H3,(H,30,33)
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n/an/a 18n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of human Vascular endothelial growth factor receptor 2


J Med Chem 46: 5375-88 (2003)


Article DOI: 10.1021/jm0301641
BindingDB Entry DOI: 10.7270/Q2V69J1X
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50024273
PNG
(CHEMBL2112040)
Show SMILES CC[C@H](C)OCc1ccc2n(CCCO)c3c4Cc5ccccc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C29H30N2O3/c1-3-17(2)34-16-18-9-10-24-21(13-18)26-23-15-30-29(33)27(23)25-20-8-5-4-7-19(20)14-22(25)28(26)31(24)11-6-12-32/h4-5,7-10,13,17,32H,3,6,11-12,14-16H2,1-2H3,(H,30,33)/t17-/m0/s1
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n/an/a 19n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against human vascular endothelial growth factor receptor 2


J Med Chem 46: 5375-88 (2003)


Article DOI: 10.1021/jm0301641
BindingDB Entry DOI: 10.7270/Q2V69J1X
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50136022
PNG
(9-ethylsulfanylmethyl-12-(3-hydroxypropyl)-6,7,12,...)
Show SMILES CCSCc1ccc2n(CCCO)c3c4Cc5ccccc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C27H26N2O2S/c1-2-32-15-16-8-9-22-19(12-16)24-21-14-28-27(31)25(21)23-18-7-4-3-6-17(18)13-20(23)26(24)29(22)10-5-11-30/h3-4,6-9,12,30H,2,5,10-11,13-15H2,1H3,(H,28,31)
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n/an/a 21n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of human Vascular endothelial growth factor receptor 2


J Med Chem 46: 5375-88 (2003)


Article DOI: 10.1021/jm0301641
BindingDB Entry DOI: 10.7270/Q2V69J1X
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50136020
PNG
(9-(1-ethylpropoxymethyl)-12-(3-hydroxypropyl)-6,7,...)
Show SMILES CCC(CC)OCc1ccc2n(CCCO)c3c4Cc5ccccc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C30H32N2O3/c1-3-20(4-2)35-17-18-10-11-25-22(14-18)27-24-16-31-30(34)28(24)26-21-9-6-5-8-19(21)15-23(26)29(27)32(25)12-7-13-33/h5-6,8-11,14,20,33H,3-4,7,12-13,15-17H2,1-2H3,(H,31,34)
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n/an/a 35n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of human Vascular endothelial growth factor receptor 2


J Med Chem 46: 5375-88 (2003)


Article DOI: 10.1021/jm0301641
BindingDB Entry DOI: 10.7270/Q2V69J1X
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50136030
PNG
(12-(3-hydroxypropyl)-6,7,12,13-tetrahydro-5H-inden...)
Show SMILES OCCCn1c2ccccc2c2c3CNC(=O)c3c3-c4ccccc4Cc3c12
Show InChI InChI=1S/C24H20N2O2/c27-11-5-10-26-19-9-4-3-8-16(19)21-18-13-25-24(28)22(18)20-15-7-2-1-6-14(15)12-17(20)23(21)26/h1-4,6-9,27H,5,10-13H2,(H,25,28)
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n/an/a 48n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of human Vascular endothelial growth factor receptor 2


J Med Chem 46: 5375-88 (2003)


Article DOI: 10.1021/jm0301641
BindingDB Entry DOI: 10.7270/Q2V69J1X
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50136031
PNG
(9-isopropoxymethyl-6,7,12,13-tetrahydro-5H-indeno[...)
Show SMILES CC(C)OCc1ccc2[nH]c3c4Cc5ccccc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C25H22N2O2/c1-13(2)29-12-14-7-8-20-17(9-14)22-19-11-26-25(28)23(19)21-16-6-4-3-5-15(16)10-18(21)24(22)27-20/h3-9,13,27H,10-12H2,1-2H3,(H,26,28)
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n/an/a 55n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of human Vascular endothelial growth factor receptor 2


J Med Chem 46: 5375-88 (2003)


Article DOI: 10.1021/jm0301641
BindingDB Entry DOI: 10.7270/Q2V69J1X
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50136028
PNG
(12-(3-hydroxypropyl)-9-isopropylsulfanylmethyl-6,7...)
Show SMILES CC(C)SCc1ccc2n(CCCO)c3c4Cc5ccccc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C28H28N2O2S/c1-16(2)33-15-17-8-9-23-20(12-17)25-22-14-29-28(32)26(22)24-19-7-4-3-6-18(19)13-21(24)27(25)30(23)10-5-11-31/h3-4,6-9,12,16,31H,5,10-11,13-15H2,1-2H3,(H,29,32)
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PubMed
n/an/a 57n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of human Vascular endothelial growth factor receptor 2


J Med Chem 46: 5375-88 (2003)


Article DOI: 10.1021/jm0301641
BindingDB Entry DOI: 10.7270/Q2V69J1X
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50136008
PNG
(12-(3-hydroxypropyl)-9-isopropoxymethyl-6,7,12,13-...)
Show SMILES CC(C)OCc1ccc2n(CCCO)c3c4Cc5ccccc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C28H28N2O3/c1-16(2)33-15-17-8-9-23-20(12-17)25-22-14-29-28(32)26(22)24-19-7-4-3-6-18(19)13-21(24)27(25)30(23)10-5-11-31/h3-4,6-9,12,16,31H,5,10-11,13-15H2,1-2H3,(H,29,32)
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n/an/a 57n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of Proto-oncogene tyrosine-protein kinase Kit


J Med Chem 46: 5375-88 (2003)


Article DOI: 10.1021/jm0301641
BindingDB Entry DOI: 10.7270/Q2V69J1X
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50136011
PNG
(9-(1-ethoxyethyl)-12-(3-hydroxypropyl)-6,7,12,13-t...)
Show SMILES CCOC(C)c1ccc2n(CCCO)c3c4Cc5ccccc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C28H28N2O3/c1-3-33-16(2)17-9-10-23-20(13-17)25-22-15-29-28(32)26(22)24-19-8-5-4-7-18(19)14-21(24)27(25)30(23)11-6-12-31/h4-5,7-10,13,16,31H,3,6,11-12,14-15H2,1-2H3,(H,29,32)
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n/an/a 65n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration against human vascular endothelial growth factor receptor 2


J Med Chem 46: 5375-88 (2003)


Article DOI: 10.1021/jm0301641
BindingDB Entry DOI: 10.7270/Q2V69J1X
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50136011
PNG
(9-(1-ethoxyethyl)-12-(3-hydroxypropyl)-6,7,12,13-t...)
Show SMILES CCOC(C)c1ccc2n(CCCO)c3c4Cc5ccccc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C28H28N2O3/c1-3-33-16(2)17-9-10-23-20(13-17)25-22-15-29-28(32)26(22)24-19-8-5-4-7-18(19)14-21(24)27(25)30(23)11-6-12-31/h4-5,7-10,13,16,31H,3,6,11-12,14-15H2,1-2H3,(H,29,32)
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n/an/a 65n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of human Vascular endothelial growth factor receptor 2


J Med Chem 46: 5375-88 (2003)


Article DOI: 10.1021/jm0301641
BindingDB Entry DOI: 10.7270/Q2V69J1X
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50136016
PNG
(12-(3-hydroxypropyl)-9-(1-methoxyethyl)-6,7,12,13-...)
Show SMILES COC(C)c1ccc2n(CCCO)c3c4Cc5ccccc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C27H26N2O3/c1-15(32-2)16-8-9-22-19(12-16)24-21-14-28-27(31)25(21)23-18-7-4-3-6-17(18)13-20(23)26(24)29(22)10-5-11-30/h3-4,6-9,12,15,30H,5,10-11,13-14H2,1-2H3,(H,28,31)
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n/an/a 73n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of human Vascular endothelial growth factor receptor 2


J Med Chem 46: 5375-88 (2003)


Article DOI: 10.1021/jm0301641
BindingDB Entry DOI: 10.7270/Q2V69J1X
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50136025
PNG
(9-bromo-12-(3-hydroxypropyl)-6,7,12,13-tetrahydro-...)
Show SMILES OCCCn1c2ccc(Br)cc2c2c3CNC(=O)c3c3-c4ccccc4Cc3c12
Show InChI InChI=1S/C24H19BrN2O2/c25-14-6-7-19-16(11-14)21-18-12-26-24(29)22(18)20-15-5-2-1-4-13(15)10-17(20)23(21)27(19)8-3-9-28/h1-2,4-7,11,28H,3,8-10,12H2,(H,26,29)
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n/an/a 104n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of human Vascular endothelial growth factor receptor 2


J Med Chem 46: 5375-88 (2003)


Article DOI: 10.1021/jm0301641
BindingDB Entry DOI: 10.7270/Q2V69J1X
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50136033
PNG
(12-(3-hydroxypropyl)-5-oxo-6,7,12,13-tetrahydro-5H...)
Show SMILES OCCCn1c2ccc(C=O)cc2c2c3CNC(=O)c3c3-c4ccccc4Cc3c12
Show InChI InChI=1S/C25H20N2O3/c28-9-3-8-27-20-7-6-14(13-29)10-17(20)22-19-12-26-25(30)23(19)21-16-5-2-1-4-15(16)11-18(21)24(22)27/h1-2,4-7,10,13,28H,3,8-9,11-12H2,(H,26,30)
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n/an/a 105n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of human Vascular endothelial growth factor receptor 2


J Med Chem 46: 5375-88 (2003)


Article DOI: 10.1021/jm0301641
BindingDB Entry DOI: 10.7270/Q2V69J1X
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50136012
PNG
(12-(2-hydroxyethyl)-6,7,12,13-tetrahydro-5H-indeno...)
Show SMILES OCCn1c2ccccc2c2c3CNC(=O)c3c3-c4ccccc4Cc3c12
Show InChI InChI=1S/C23H18N2O2/c26-10-9-25-18-8-4-3-7-15(18)20-17-12-24-23(27)21(17)19-14-6-2-1-5-13(14)11-16(19)22(20)25/h1-8,26H,9-12H2,(H,24,27)
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n/an/a 107n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of human Vascular endothelial growth factor receptor 2


J Med Chem 46: 5375-88 (2003)


Article DOI: 10.1021/jm0301641
BindingDB Entry DOI: 10.7270/Q2V69J1X
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM14177
PNG
(3,13-diazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,...)
Show SMILES O=C1NCc2c1c-1c(Cc3ccccc-13)c1[nH]c3ccccc3c21
Show InChI InChI=1S/C21H14N2O/c24-21-19-15(10-22-21)18-13-7-3-4-8-16(13)23-20(18)14-9-11-5-1-2-6-12(11)17(14)19/h1-8,23H,9-10H2,(H,22,24)
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n/an/a 110n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of human Vascular endothelial growth factor receptor 2


J Med Chem 46: 5375-88 (2003)


Article DOI: 10.1021/jm0301641
BindingDB Entry DOI: 10.7270/Q2V69J1X
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50136010
PNG
(9-(1-hydroxyethyl)-12-(3-hydroxypropyl)-6,7,12,13-...)
Show SMILES CC(O)c1ccc2n(CCCO)c3c4Cc5ccccc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C26H24N2O3/c1-14(30)15-7-8-21-18(11-15)23-20-13-27-26(31)24(20)22-17-6-3-2-5-16(17)12-19(22)25(23)28(21)9-4-10-29/h2-3,5-8,11,14,29-30H,4,9-10,12-13H2,1H3,(H,27,31)
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n/an/a 111n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of human Vascular endothelial growth factor receptor 2


J Med Chem 46: 5375-88 (2003)


Article DOI: 10.1021/jm0301641
BindingDB Entry DOI: 10.7270/Q2V69J1X
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50136029
PNG
(9-(1-butoxyethyl)-12-(3-hydroxypropyl)-6,7,12,13-t...)
Show SMILES CCCCOC(C)c1ccc2n(CCCO)c3c4Cc5ccccc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C30H32N2O3/c1-3-4-14-35-18(2)19-10-11-25-22(15-19)27-24-17-31-30(34)28(24)26-21-9-6-5-8-20(21)16-23(26)29(27)32(25)12-7-13-33/h5-6,8-11,15,18,33H,3-4,7,12-14,16-17H2,1-2H3,(H,31,34)
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n/an/a 130n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of human Vascular endothelial growth factor receptor 2


J Med Chem 46: 5375-88 (2003)


Article DOI: 10.1021/jm0301641
BindingDB Entry DOI: 10.7270/Q2V69J1X
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM50136008
PNG
(12-(3-hydroxypropyl)-9-isopropoxymethyl-6,7,12,13-...)
Show SMILES CC(C)OCc1ccc2n(CCCO)c3c4Cc5ccccc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C28H28N2O3/c1-16(2)33-15-17-8-9-23-20(12-17)25-22-14-29-28(32)26(22)24-19-7-4-3-6-18(19)13-21(24)27(25)30(23)10-5-11-31/h3-4,6-9,12,16,31H,5,10-11,13-15H2,1-2H3,(H,29,32)
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n/an/a 162n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of Fibroblast growth factor receptor 1


J Med Chem 46: 5375-88 (2003)


Article DOI: 10.1021/jm0301641
BindingDB Entry DOI: 10.7270/Q2V69J1X
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50136023
PNG
(9-methyl-12-(3-hydroxypropyl)-6,7,12,13-tetrahydro...)
Show SMILES Cc1ccc2n(CCCO)c3c4Cc5ccccc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C25H22N2O2/c1-14-7-8-20-17(11-14)22-19-13-26-25(29)23(19)21-16-6-3-2-5-15(16)12-18(21)24(22)27(20)9-4-10-28/h2-3,5-8,11,28H,4,9-10,12-13H2,1H3,(H,26,29)
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n/an/a 163n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of human Vascular endothelial growth factor receptor 2


J Med Chem 46: 5375-88 (2003)


Article DOI: 10.1021/jm0301641
BindingDB Entry DOI: 10.7270/Q2V69J1X
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50136032
PNG
(1-[12-(3-hydroxypropyl)-5-oxo-6,7,12,13-tetrahydro...)
Show SMILES CC(=O)c1ccc2n(CCCO)c3c4Cc5ccccc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C26H22N2O3/c1-14(30)15-7-8-21-18(11-15)23-20-13-27-26(31)24(20)22-17-6-3-2-5-16(17)12-19(22)25(23)28(21)9-4-10-29/h2-3,5-8,11,29H,4,9-10,12-13H2,1H3,(H,27,31)
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n/an/a 187n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of human Vascular endothelial growth factor receptor 2


J Med Chem 46: 5375-88 (2003)


Article DOI: 10.1021/jm0301641
BindingDB Entry DOI: 10.7270/Q2V69J1X
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50136026
PNG
(9-hydroxymethyl-12-(3-hydroxypropyl)-6,7,12,13-tet...)
Show SMILES OCCCn1c2ccc(CO)cc2c2c3CNC(=O)c3c3-c4ccccc4Cc3c12
Show InChI InChI=1S/C25H22N2O3/c28-9-3-8-27-20-7-6-14(13-29)10-17(20)22-19-12-26-25(30)23(19)21-16-5-2-1-4-15(16)11-18(21)24(22)27/h1-2,4-7,10,28-29H,3,8-9,11-13H2,(H,26,30)
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n/an/a 208n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of human Vascular endothelial growth factor receptor 2


J Med Chem 46: 5375-88 (2003)


Article DOI: 10.1021/jm0301641
BindingDB Entry DOI: 10.7270/Q2V69J1X
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50136009
PNG
(12-(3-hydroxypropyl)-9-isopentyloxymethyl-6,7,12,1...)
Show SMILES CC(C)CCOCc1ccc2n(CCCO)c3c4Cc5ccccc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C30H32N2O3/c1-18(2)10-13-35-17-19-8-9-25-22(14-19)27-24-16-31-30(34)28(24)26-21-7-4-3-6-20(21)15-23(26)29(27)32(25)11-5-12-33/h3-4,6-9,14,18,33H,5,10-13,15-17H2,1-2H3,(H,31,34)
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n/an/a 276n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of human Vascular endothelial growth factor receptor 2


J Med Chem 46: 5375-88 (2003)


Article DOI: 10.1021/jm0301641
BindingDB Entry DOI: 10.7270/Q2V69J1X
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50136014
PNG
(12-(3-hydroxypropyl)-9-isopropylsulfinylmethyl-6,7...)
Show SMILES CC(C)S(=O)Cc1ccc2n(CCCO)c3c4Cc5ccccc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C28H28N2O3S/c1-16(2)34(33)15-17-8-9-23-20(12-17)25-22-14-29-28(32)26(22)24-19-7-4-3-6-18(19)13-21(24)27(25)30(23)10-5-11-31/h3-4,6-9,12,16,31H,5,10-11,13-15H2,1-2H3,(H,29,32)
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n/an/a 309n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of human Vascular endothelial growth factor receptor 2


J Med Chem 46: 5375-88 (2003)


Article DOI: 10.1021/jm0301641
BindingDB Entry DOI: 10.7270/Q2V69J1X
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM50136008
PNG
(12-(3-hydroxypropyl)-9-isopropoxymethyl-6,7,12,13-...)
Show SMILES CC(C)OCc1ccc2n(CCCO)c3c4Cc5ccccc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C28H28N2O3/c1-16(2)33-15-17-8-9-23-20(12-17)25-22-14-29-28(32)26(22)24-19-7-4-3-6-18(19)13-21(24)27(25)30(23)10-5-11-31/h3-4,6-9,12,16,31H,5,10-11,13-15H2,1-2H3,(H,29,32)
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n/an/a 406n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of Platelet-derived growth factor receptor beta


J Med Chem 46: 5375-88 (2003)


Article DOI: 10.1021/jm0301641
BindingDB Entry DOI: 10.7270/Q2V69J1X
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50136027
PNG
(12-(3-hydroxypropyl)-9-(1-isopropoxyethyl)-6,7,12,...)
Show SMILES CC(C)OC(C)c1ccc2n(CCCO)c3c4Cc5ccccc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C29H30N2O3/c1-16(2)34-17(3)18-9-10-24-21(13-18)26-23-15-30-29(33)27(23)25-20-8-5-4-7-19(20)14-22(25)28(26)31(24)11-6-12-32/h4-5,7-10,13,16-17,32H,6,11-12,14-15H2,1-3H3,(H,30,33)
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n/an/a 411n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of human Vascular endothelial growth factor receptor 2


J Med Chem 46: 5375-88 (2003)


Article DOI: 10.1021/jm0301641
BindingDB Entry DOI: 10.7270/Q2V69J1X
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM14173
PNG
(3,13-diazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,...)
Show SMILES O=C1NCc2c-3c(Cc4ccccc-34)c3[nH]c4ccccc4c3c12
Show InChI InChI=1S/C21H14N2O/c24-21-19-15(10-22-21)17-12-6-2-1-5-11(12)9-14(17)20-18(19)13-7-3-4-8-16(13)23-20/h1-8,23H,9-10H2,(H,22,24)
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n/an/a 414n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of human Vascular endothelial growth factor receptor 2


J Med Chem 46: 5375-88 (2003)


Article DOI: 10.1021/jm0301641
BindingDB Entry DOI: 10.7270/Q2V69J1X
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (human))
BDBM50136008
PNG
(12-(3-hydroxypropyl)-9-isopropoxymethyl-6,7,12,13-...)
Show SMILES CC(C)OCc1ccc2n(CCCO)c3c4Cc5ccccc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C28H28N2O3/c1-16(2)33-15-17-8-9-23-20(12-17)25-22-14-29-28(32)26(22)24-19-7-4-3-6-18(19)13-21(24)27(25)30(23)10-5-11-31/h3-4,6-9,12,16,31H,5,10-11,13-15H2,1-2H3,(H,29,32)
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n/an/a 448n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of c-Jun N-terminal kinase 1-beta 1


J Med Chem 46: 5375-88 (2003)


Article DOI: 10.1021/jm0301641
BindingDB Entry DOI: 10.7270/Q2V69J1X
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Chk1


(Homo sapiens)
BDBM50136008
PNG
(12-(3-hydroxypropyl)-9-isopropoxymethyl-6,7,12,13-...)
Show SMILES CC(C)OCc1ccc2n(CCCO)c3c4Cc5ccccc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C28H28N2O3/c1-16(2)33-15-17-8-9-23-20(12-17)25-22-14-29-28(32)26(22)24-19-7-4-3-6-18(19)13-21(24)27(25)30(23)10-5-11-31/h3-4,6-9,12,16,31H,5,10-11,13-15H2,1-2H3,(H,29,32)
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n/an/a>3.00E+3n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of Serine/threonine-protein kinase Chk1


J Med Chem 46: 5375-88 (2003)


Article DOI: 10.1021/jm0301641
BindingDB Entry DOI: 10.7270/Q2V69J1X
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM50136008
PNG
(12-(3-hydroxypropyl)-9-isopropoxymethyl-6,7,12,13-...)
Show SMILES CC(C)OCc1ccc2n(CCCO)c3c4Cc5ccccc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C28H28N2O3/c1-16(2)33-15-17-8-9-23-20(12-17)25-22-14-29-28(32)26(22)24-19-7-4-3-6-18(19)13-21(24)27(25)30(23)10-5-11-31/h3-4,6-9,12,16,31H,5,10-11,13-15H2,1-2H3,(H,29,32)
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n/an/a>3.00E+3n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of TrkA receptor


J Med Chem 46: 5375-88 (2003)


Article DOI: 10.1021/jm0301641
BindingDB Entry DOI: 10.7270/Q2V69J1X
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase CHK2


(Homo sapiens (Human))
BDBM50136008
PNG
(12-(3-hydroxypropyl)-9-isopropoxymethyl-6,7,12,13-...)
Show SMILES CC(C)OCc1ccc2n(CCCO)c3c4Cc5ccccc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C28H28N2O3/c1-16(2)33-15-17-8-9-23-20(12-17)25-22-14-29-28(32)26(22)24-19-7-4-3-6-18(19)13-21(24)27(25)30(23)10-5-11-31/h3-4,6-9,12,16,31H,5,10-11,13-15H2,1-2H3,(H,29,32)
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n/an/a>3.00E+3n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of Serine/threonine-protein kinase Chk2 (CDS1 receptor)


J Med Chem 46: 5375-88 (2003)


Article DOI: 10.1021/jm0301641
BindingDB Entry DOI: 10.7270/Q2V69J1X
More data for this
Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3


(Homo sapiens-Homo sapiens (human))
BDBM50136008
PNG
(12-(3-hydroxypropyl)-9-isopropoxymethyl-6,7,12,13-...)
Show SMILES CC(C)OCc1ccc2n(CCCO)c3c4Cc5ccccc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C28H28N2O3/c1-16(2)33-15-17-8-9-23-20(12-17)25-22-14-29-28(32)26(22)24-19-7-4-3-6-18(19)13-21(24)27(25)30(23)10-5-11-31/h3-4,6-9,12,16,31H,5,10-11,13-15H2,1-2H3,(H,29,32)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of Cyclin-dependent kinase 1-cyclin B


J Med Chem 46: 5375-88 (2003)


Article DOI: 10.1021/jm0301641
BindingDB Entry DOI: 10.7270/Q2V69J1X
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM50136008
PNG
(12-(3-hydroxypropyl)-9-isopropoxymethyl-6,7,12,13-...)
Show SMILES CC(C)OCc1ccc2n(CCCO)c3c4Cc5ccccc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C28H28N2O3/c1-16(2)33-15-17-8-9-23-20(12-17)25-22-14-29-28(32)26(22)24-19-7-4-3-6-18(19)13-21(24)27(25)30(23)10-5-11-31/h3-4,6-9,12,16,31H,5,10-11,13-15H2,1-2H3,(H,29,32)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of Mitogen-activated protein kinase p38 alpha


J Med Chem 46: 5375-88 (2003)


Article DOI: 10.1021/jm0301641
BindingDB Entry DOI: 10.7270/Q2V69J1X
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM50136008
PNG
(12-(3-hydroxypropyl)-9-isopropoxymethyl-6,7,12,13-...)
Show SMILES CC(C)OCc1ccc2n(CCCO)c3c4Cc5ccccc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C28H28N2O3/c1-16(2)33-15-17-8-9-23-20(12-17)25-22-14-29-28(32)26(22)24-19-7-4-3-6-18(19)13-21(24)27(25)30(23)10-5-11-31/h3-4,6-9,12,16,31H,5,10-11,13-15H2,1-2H3,(H,29,32)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of beta-insulin receptor kinase


J Med Chem 46: 5375-88 (2003)


Article DOI: 10.1021/jm0301641
BindingDB Entry DOI: 10.7270/Q2V69J1X
More data for this
Ligand-Target Pair
Protein kinase C, PKC; classical


(Rattus norvegicus (Rat)-Rattus norvegicus (rat))
BDBM50136008
PNG
(12-(3-hydroxypropyl)-9-isopropoxymethyl-6,7,12,13-...)
Show SMILES CC(C)OCc1ccc2n(CCCO)c3c4Cc5ccccc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C28H28N2O3/c1-16(2)33-15-17-8-9-23-20(12-17)25-22-14-29-28(32)26(22)24-19-7-4-3-6-18(19)13-21(24)27(25)30(23)10-5-11-31/h3-4,6-9,12,16,31H,5,10-11,13-15H2,1-2H3,(H,29,32)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of rat brain Protein kinase C


J Med Chem 46: 5375-88 (2003)


Article DOI: 10.1021/jm0301641
BindingDB Entry DOI: 10.7270/Q2V69J1X
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (human))
BDBM50136008
PNG
(12-(3-hydroxypropyl)-9-isopropoxymethyl-6,7,12,13-...)
Show SMILES CC(C)OCc1ccc2n(CCCO)c3c4Cc5ccccc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C28H28N2O3/c1-16(2)33-15-17-8-9-23-20(12-17)25-22-14-29-28(32)26(22)24-19-7-4-3-6-18(19)13-21(24)27(25)30(23)10-5-11-31/h3-4,6-9,12,16,31H,5,10-11,13-15H2,1-2H3,(H,29,32)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of Tyrosine protein kinase receptor TIE-2


J Med Chem 46: 5375-88 (2003)


Article DOI: 10.1021/jm0301641
BindingDB Entry DOI: 10.7270/Q2V69J1X
More data for this
Ligand-Target Pair