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Compile Data Set for Download or QSAR

Found 2989 hits from Cephalon, Inc.   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50355120
PNG
(CHEMBL1835782)
Show SMILES C[C@@H]1CCCN1CCCOc1ccc(cc1)-c1nn(C)c(=O)c2CCCc12
Show InChI InChI=1S/C22H29N3O2/c1-16-6-4-13-25(16)14-5-15-27-18-11-9-17(10-12-18)21-19-7-3-8-20(19)22(26)24(2)23-21/h9-12,16H,3-8,13-15H2,1-2H3/t16-/m1/s1
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0.400n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-NAMH from human histamine H3 receptor expressed in CHO cells


Bioorg Med Chem Lett 21: 6126-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.08.045
BindingDB Entry DOI: 10.7270/Q2T72JFP
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50355121
PNG
(CHEMBL1835783)
Show SMILES Cn1nc(c2CCCc2c1=O)-c1ccc(OCCCN2CCCCC2)cc1
Show InChI InChI=1S/C22H29N3O2/c1-24-22(26)20-8-5-7-19(20)21(23-24)17-9-11-18(12-10-17)27-16-6-15-25-13-3-2-4-14-25/h9-12H,2-8,13-16H2,1H3
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0.5n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-NAMH from human histamine H3 receptor expressed in CHO cells


Bioorg Med Chem Lett 21: 6126-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.08.045
BindingDB Entry DOI: 10.7270/Q2T72JFP
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50384937
PNG
(CHEMBL2036648)
Show SMILES C[C@@H]1CCCN1CCCOc1ccc(cc1)C(=O)CN1CCN(CC1)C(=O)c1ccc(F)cc1
Show InChI InChI=1S/C27H34FN3O3/c1-21-4-2-13-30(21)14-3-19-34-25-11-7-22(8-12-25)26(32)20-29-15-17-31(18-16-29)27(33)23-5-9-24(28)10-6-23/h5-12,21H,2-4,13-20H2,1H3/t21-/m1/s1
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0.600n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]NAMH from human histamine H3 receptor expressed in CHO cells


Bioorg Med Chem Lett 22: 2807-10 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.081
BindingDB Entry DOI: 10.7270/Q26M37VX
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50358567
PNG
(CHEMBL1923729)
Show SMILES C[C@@H]1CCCN1CCCOc1ccc(cc1)-c1ccc(=O)n(C)c1
Show InChI InChI=1S/C20H26N2O2/c1-16-5-3-12-22(16)13-4-14-24-19-9-6-17(7-10-19)18-8-11-20(23)21(2)15-18/h6-11,15-16H,3-5,12-14H2,1-2H3/t16-/m1/s1
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0.700n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]NAMH from human histamine H3 receptor expressed in CHO cells


Bioorg Med Chem Lett 21: 7076-80 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.091
BindingDB Entry DOI: 10.7270/Q26H4HVK
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50355124
PNG
(CHEMBL1835786)
Show SMILES C[C@@H]1CCCN1CCCOc1ccc(cc1)-c1nn(C)c(=O)c2CCCCc12
Show InChI InChI=1S/C23H31N3O2/c1-17-7-5-14-26(17)15-6-16-28-19-12-10-18(11-13-19)22-20-8-3-4-9-21(20)23(27)25(2)24-22/h10-13,17H,3-9,14-16H2,1-2H3/t17-/m1/s1
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0.800n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-NAMH from human histamine H3 receptor expressed in CHO cells


Bioorg Med Chem Lett 21: 6126-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.08.045
BindingDB Entry DOI: 10.7270/Q2T72JFP
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50355126
PNG
(CHEMBL1835706)
Show SMILES Cn1nc(-c2ccc(OCCCN3CCCCC3)cc2)c2ccccc2c1=O
Show InChI InChI=1S/C23H27N3O2/c1-25-23(27)21-9-4-3-8-20(21)22(24-25)18-10-12-19(13-11-18)28-17-7-16-26-14-5-2-6-15-26/h3-4,8-13H,2,5-7,14-17H2,1H3
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0.800n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-NAMH from human histamine H3 receptor expressed in CHO cells


Bioorg Med Chem Lett 21: 6126-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.08.045
BindingDB Entry DOI: 10.7270/Q2T72JFP
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50355141
PNG
(CHEMBL1835704)
Show SMILES C[C@@H]1CCCN1CCCOc1ccc(cc1)-c1nn(C)c(=O)c2ccccc12
Show InChI InChI=1S/C23H27N3O2/c1-17-7-5-14-26(17)15-6-16-28-19-12-10-18(11-13-19)22-20-8-3-4-9-21(20)23(27)25(2)24-22/h3-4,8-13,17H,5-7,14-16H2,1-2H3/t17-/m1/s1
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0.800n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-NAMH from human histamine H3 receptor expressed in CHO cells


Bioorg Med Chem Lett 21: 6126-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.08.045
BindingDB Entry DOI: 10.7270/Q2T72JFP
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50384940
PNG
(CHEMBL2036651)
Show SMILES C[C@@H]1CCCN1CCCOc1ccc(cc1)C(=O)CN1CCN(CC1)C(=O)c1cccn1C
Show InChI InChI=1S/C26H36N4O3/c1-21-6-3-13-29(21)14-5-19-33-23-10-8-22(9-11-23)25(31)20-28-15-17-30(18-16-28)26(32)24-7-4-12-27(24)2/h4,7-12,21H,3,5-6,13-20H2,1-2H3/t21-/m1/s1
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0.900n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]NAMH from human histamine H3 receptor expressed in CHO cells


Bioorg Med Chem Lett 22: 2807-10 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.081
BindingDB Entry DOI: 10.7270/Q26M37VX
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50358577
PNG
(CHEMBL1923738)
Show SMILES C[C@@H]1CCCN1CCCOc1ccc(cc1)-c1cn(C)c(=O)c2ccccc12
Show InChI InChI=1S/C24H28N2O2/c1-18-7-5-14-26(18)15-6-16-28-20-12-10-19(11-13-20)23-17-25(2)24(27)22-9-4-3-8-21(22)23/h3-4,8-13,17-18H,5-7,14-16H2,1-2H3/t18-/m1/s1
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0.900n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]NAMH from human histamine H3 receptor expressed in CHO cells


Bioorg Med Chem Lett 21: 7076-80 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.091
BindingDB Entry DOI: 10.7270/Q26H4HVK
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50355124
PNG
(CHEMBL1835786)
Show SMILES C[C@@H]1CCCN1CCCOc1ccc(cc1)-c1nn(C)c(=O)c2CCCCc12
Show InChI InChI=1S/C23H31N3O2/c1-17-7-5-14-26(17)15-6-16-28-19-12-10-18(11-13-19)22-20-8-3-4-9-21(20)23(27)25(2)24-22/h10-13,17H,3-9,14-16H2,1-2H3/t17-/m1/s1
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1.20n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-NAMH from rat histamine H3 receptor expressed in CHO cells


Bioorg Med Chem Lett 21: 6126-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.08.045
BindingDB Entry DOI: 10.7270/Q2T72JFP
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50384941
PNG
(CHEMBL2036652)
Show SMILES C[C@@H]1CCCN1CCCOc1ccc(cc1)C(=O)CN1CCN(CC1)C(=O)c1cc2ccccc2s1
Show InChI InChI=1S/C29H35N3O3S/c1-22-6-4-13-31(22)14-5-19-35-25-11-9-23(10-12-25)26(33)21-30-15-17-32(18-16-30)29(34)28-20-24-7-2-3-8-27(24)36-28/h2-3,7-12,20,22H,4-6,13-19,21H2,1H3/t22-/m1/s1
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1.20n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]NAMH from human histamine H3 receptor expressed in CHO cells


Bioorg Med Chem Lett 22: 2807-10 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.081
BindingDB Entry DOI: 10.7270/Q26M37VX
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50350022
PNG
(CHEMBL1813057)
Show SMILES C[C@@H]1CCCN1CCCOc1ccc(cc1)-c1ccc(=O)n(C)n1
Show InChI InChI=1S/C19H25N3O2/c1-15-5-3-12-22(15)13-4-14-24-17-8-6-16(7-9-17)18-10-11-19(23)21(2)20-18/h6-11,15H,3-5,12-14H2,1-2H3/t15-/m1/s1
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1.40n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]NAMH from human histamine H3 receptor expressed in CHO cells


J Med Chem 54: 4781-92 (2011)


Article DOI: 10.1021/jm200401v
BindingDB Entry DOI: 10.7270/Q2W66MRB
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50353165
PNG
(CHEMBL1829472)
Show SMILES C[C@@H]1CCCN1CCCOc1ccc(cc1)-c1ccc(=O)n(n1)-c1ncccn1
Show InChI InChI=1S/C22H25N5O2/c1-17-5-2-14-26(17)15-4-16-29-19-8-6-18(7-9-19)20-10-11-21(28)27(25-20)22-23-12-3-13-24-22/h3,6-13,17H,2,4-5,14-16H2,1H3/t17-/m1/s1
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1.40n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]NAMH from human cloned histamine 3 receptor expressed in CHO cells


Bioorg Med Chem Lett 21: 5493-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.108
BindingDB Entry DOI: 10.7270/Q2KP8359
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50350022
PNG
(CHEMBL1813057)
Show SMILES C[C@@H]1CCCN1CCCOc1ccc(cc1)-c1ccc(=O)n(C)n1
Show InChI InChI=1S/C19H25N3O2/c1-15-5-3-12-22(15)13-4-14-24-17-8-6-16(7-9-17)18-10-11-19(23)21(2)20-18/h6-11,15H,3-5,12-14H2,1-2H3/t15-/m1/s1
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1.40n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]NAMH from human cloned histamine 3 receptor expressed in CHO cells


Bioorg Med Chem Lett 21: 5493-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.108
BindingDB Entry DOI: 10.7270/Q2KP8359
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50350022
PNG
(CHEMBL1813057)
Show SMILES C[C@@H]1CCCN1CCCOc1ccc(cc1)-c1ccc(=O)n(C)n1
Show InChI InChI=1S/C19H25N3O2/c1-15-5-3-12-22(15)13-4-14-24-17-8-6-16(7-9-17)18-10-11-19(23)21(2)20-18/h6-11,15H,3-5,12-14H2,1-2H3/t15-/m1/s1
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1.40n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-NAMH from human histamine H3 receptor expressed in CHO cells


Bioorg Med Chem Lett 21: 6126-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.08.045
BindingDB Entry DOI: 10.7270/Q2T72JFP
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50355138
PNG
(CHEMBL1835708)
Show SMILES Cn1nc(-c2ccc(OCCCN3CCCCCC3)cc2)c2ccccc2c1=O
Show InChI InChI=1S/C24H29N3O2/c1-26-24(28)22-10-5-4-9-21(22)23(25-26)19-11-13-20(14-12-19)29-18-8-17-27-15-6-2-3-7-16-27/h4-5,9-14H,2-3,6-8,15-18H2,1H3
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1.40n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-NAMH from human histamine H3 receptor expressed in CHO cells


Bioorg Med Chem Lett 21: 6126-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.08.045
BindingDB Entry DOI: 10.7270/Q2T72JFP
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50355130
PNG
(CHEMBL1835778)
Show SMILES CCCn1nc(-c2ccc(OCCCN3CCC[C@H]3C)cc2)c2sccc2c1=O
Show InChI InChI=1S/C23H29N3O2S/c1-3-12-26-23(27)20-11-16-29-22(20)21(24-26)18-7-9-19(10-8-18)28-15-5-14-25-13-4-6-17(25)2/h7-11,16-17H,3-6,12-15H2,1-2H3/t17-/m1/s1
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1.5n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-NAMH from human histamine H3 receptor expressed in CHO cells


Bioorg Med Chem Lett 21: 6126-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.08.045
BindingDB Entry DOI: 10.7270/Q2T72JFP
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50355125
PNG
(CHEMBL1835787)
Show SMILES Cn1nc(-c2ccc(OCCCN3CCCCC3)cc2)c2CCCCc2c1=O
Show InChI InChI=1S/C23H31N3O2/c1-25-23(27)21-9-4-3-8-20(21)22(24-25)18-10-12-19(13-11-18)28-17-7-16-26-14-5-2-6-15-26/h10-13H,2-9,14-17H2,1H3
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1.5n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-NAMH from human histamine H3 receptor expressed in CHO cells


Bioorg Med Chem Lett 21: 6126-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.08.045
BindingDB Entry DOI: 10.7270/Q2T72JFP
More data for this
Ligand-Target Pair
Serotonin 3 (5-HT3) receptor


(Homo sapiens (Human))
BDBM50365250
PNG
(CHEMBL1958323)
Show SMILES C[C@@H]1CCCN1CCCOc1ccc(cc1)-c1cc(=O)[nH]nc1C
Show InChI InChI=1S/C19H25N3O2/c1-14-5-3-10-22(14)11-4-12-24-17-8-6-16(7-9-17)18-13-19(23)21-20-15(18)2/h6-9,13-14H,3-5,10-12H2,1-2H3,(H,21,23)/t14-/m1/s1
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1.60n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]NAMH from human cloned 5HT3 receptor expressed in CHO cells


J Med Chem 55: 414-23 (2012)


Article DOI: 10.1021/jm201295j
BindingDB Entry DOI: 10.7270/Q2S46SFR
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM50361051
PNG
(CHEMBL1935590)
Show SMILES Fc1cccc(c1)S(=O)(=O)c1ccc2c3CCNCc3oc2c1
Show InChI InChI=1S/C17H14FNO3S/c18-11-2-1-3-12(8-11)23(20,21)13-4-5-14-15-6-7-19-10-17(15)22-16(14)9-13/h1-5,8-9,19H,6-7,10H2
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1.60n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from full length human 5HT6 receptor


Bioorg Med Chem Lett 22: 120-3 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.050
BindingDB Entry DOI: 10.7270/Q24Q7VFX
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50355122
PNG
(CHEMBL1835784)
Show SMILES C[C@@H]1CCCN1CCCOc1ccc(cc1)C1=NN(C)C(=O)C2CCCC12
Show InChI InChI=1S/C22H31N3O2/c1-16-6-4-13-25(16)14-5-15-27-18-11-9-17(10-12-18)21-19-7-3-8-20(19)22(26)24(2)23-21/h9-12,16,19-20H,3-8,13-15H2,1-2H3/t16-,19?,20?/m1/s1
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1.60n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-NAMH from human histamine H3 receptor expressed in CHO cells


Bioorg Med Chem Lett 21: 6126-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.08.045
BindingDB Entry DOI: 10.7270/Q2T72JFP
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50355139
PNG
(CHEMBL1835707)
Show SMILES Cn1nc(-c2ccc(OCCCN3CCCC3)cc2)c2ccccc2c1=O
Show InChI InChI=1S/C22H25N3O2/c1-24-22(26)20-8-3-2-7-19(20)21(23-24)17-9-11-18(12-10-17)27-16-6-15-25-13-4-5-14-25/h2-3,7-12H,4-6,13-16H2,1H3
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1.70n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-NAMH from human histamine H3 receptor expressed in CHO cells


Bioorg Med Chem Lett 21: 6126-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.08.045
BindingDB Entry DOI: 10.7270/Q2T72JFP
More data for this
Ligand-Target Pair
Serotonin 3 (5-HT3) receptor


(Homo sapiens (Human))
BDBM50365260
PNG
(CHEMBL1958333)
Show SMILES C[C@@H]1CCCN1CCCOc1ccc(cc1)-c1cc(=O)n(nc1C)-c1ccccn1
Show InChI InChI=1S/C24H28N4O2/c1-18-7-5-14-27(18)15-6-16-30-21-11-9-20(10-12-21)22-17-24(29)28(26-19(22)2)23-8-3-4-13-25-23/h3-4,8-13,17-18H,5-7,14-16H2,1-2H3/t18-/m1/s1
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1.70n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]NAMH from human cloned 5HT3 receptor expressed in CHO cells


J Med Chem 55: 414-23 (2012)


Article DOI: 10.1021/jm201295j
BindingDB Entry DOI: 10.7270/Q2S46SFR
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50262939
PNG
(2-Methyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}pheny...)
Show SMILES Cc1nc2cccc(c2c(=O)n1-c1ccc(OCCCN2CCCC2)cc1)C(F)(F)F
Show InChI InChI=1S/C23H24F3N3O2/c1-16-27-20-7-4-6-19(23(24,25)26)21(20)22(30)29(16)17-8-10-18(11-9-17)31-15-5-14-28-12-2-3-13-28/h4,6-11H,2-3,5,12-15H2,1H3
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1.70n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human H3 receptor


J Med Chem 54: 4781-92 (2011)


Article DOI: 10.1021/jm200401v
BindingDB Entry DOI: 10.7270/Q2W66MRB
More data for this
Ligand-Target Pair
Serotonin 3 (5-HT3) receptor


(Homo sapiens (Human))
BDBM50363325
PNG
(CHEMBL1945843)
Show SMILES C[C@@H]1CCCN1CCCOc1ccc(cc1)-c1cnn(-c2ccccn2)c(=O)c1
Show InChI InChI=1S/C23H26N4O2/c1-18-6-4-13-26(18)14-5-15-29-21-10-8-19(9-11-21)20-16-23(28)27(25-17-20)22-7-2-3-12-24-22/h2-3,7-12,16-18H,4-6,13-15H2,1H3/t18-/m1/s1
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1.70n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]NAMH from human cloned 5HT3 receptor expressed in CHO cells


J Med Chem 55: 414-23 (2012)


Article DOI: 10.1021/jm201295j
BindingDB Entry DOI: 10.7270/Q2S46SFR
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50363325
PNG
(CHEMBL1945843)
Show SMILES C[C@@H]1CCCN1CCCOc1ccc(cc1)-c1cnn(-c2ccccn2)c(=O)c1
Show InChI InChI=1S/C23H26N4O2/c1-18-6-4-13-26(18)14-5-15-29-21-10-8-19(9-11-21)20-16-23(28)27(25-17-20)22-7-2-3-12-24-22/h2-3,7-12,16-18H,4-6,13-15H2,1H3/t18-/m1/s1
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1.70n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human histamine H3 receptor


Bioorg Med Chem Lett 22: 1073-7 (2012)


Article DOI: 10.1016/j.bmcl.2011.11.118
BindingDB Entry DOI: 10.7270/Q2K64JHT
More data for this
Ligand-Target Pair
Serotonin 3 (5-HT3) receptor


(Homo sapiens (Human))
BDBM50365258
PNG
(CHEMBL1958331)
Show SMILES C[C@@H]1CCCN1CCCOc1ccc(cc1)-c1cnn(-c2cccc(C)n2)c(=O)c1
Show InChI InChI=1S/C24H28N4O2/c1-18-6-3-8-23(26-18)28-24(29)16-21(17-25-28)20-9-11-22(12-10-20)30-15-5-14-27-13-4-7-19(27)2/h3,6,8-12,16-17,19H,4-5,7,13-15H2,1-2H3/t19-/m1/s1
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1.80n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]NAMH from human cloned 5HT3 receptor expressed in CHO cells


J Med Chem 55: 414-23 (2012)


Article DOI: 10.1021/jm201295j
BindingDB Entry DOI: 10.7270/Q2S46SFR
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50358572
PNG
(CHEMBL1923733)
Show SMILES C[C@@H]1CCCN1CCCOc1ccc(cc1)-c1ccc(=O)n(c1)-c1ccccc1
Show InChI InChI=1S/C25H28N2O2/c1-20-7-5-16-26(20)17-6-18-29-24-13-10-21(11-14-24)22-12-15-25(28)27(19-22)23-8-3-2-4-9-23/h2-4,8-15,19-20H,5-7,16-18H2,1H3/t20-/m1/s1
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1.80n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]NAMH from human histamine H3 receptor expressed in CHO cells


Bioorg Med Chem Lett 21: 7076-80 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.091
BindingDB Entry DOI: 10.7270/Q26H4HVK
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50355138
PNG
(CHEMBL1835708)
Show SMILES Cn1nc(-c2ccc(OCCCN3CCCCCC3)cc2)c2ccccc2c1=O
Show InChI InChI=1S/C24H29N3O2/c1-26-24(28)22-10-5-4-9-21(22)23(25-26)19-11-13-20(14-12-19)29-18-8-17-27-15-6-2-3-7-16-27/h4-5,9-14H,2-3,6-8,15-18H2,1H3
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1.80n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-NAMH from rat histamine H3 receptor expressed in CHO cells


Bioorg Med Chem Lett 21: 6126-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.08.045
BindingDB Entry DOI: 10.7270/Q2T72JFP
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50364972
PNG
(CHEMBL1950738)
Show SMILES Cn1nc(ccc1=O)-c1ccc(OC2CCN(CC2)C2CCC2)nc1
Show InChI InChI=1S/C19H24N4O2/c1-22-19(24)8-6-17(21-22)14-5-7-18(20-13-14)25-16-9-11-23(12-10-16)15-3-2-4-15/h5-8,13,15-16H,2-4,9-12H2,1H3
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1.80n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]NAMH from human histamine H3 receptor expressed in CHO cells


Bioorg Med Chem Lett 22: 1504-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.026
BindingDB Entry DOI: 10.7270/Q2W37WSF
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50355135
PNG
(CHEMBL1835773)
Show SMILES CC(C)n1nc(-c2ccc(OCCCN3CCCCC3)cc2)c2sccc2c1=O
Show InChI InChI=1S/C23H29N3O2S/c1-17(2)26-23(27)20-11-16-29-22(20)21(24-26)18-7-9-19(10-8-18)28-15-6-14-25-12-4-3-5-13-25/h7-11,16-17H,3-6,12-15H2,1-2H3
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1.90n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-NAMH from human histamine H3 receptor expressed in CHO cells


Bioorg Med Chem Lett 21: 6126-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.08.045
BindingDB Entry DOI: 10.7270/Q2T72JFP
More data for this
Ligand-Target Pair
Serotonin 3 (5-HT3) receptor


(Homo sapiens (Human))
BDBM50365246
PNG
(CHEMBL1958133)
Show SMILES C[C@@H]1CCCN1CCCOc1ccc(cc1)-c1cnn(C)c(=O)c1
Show InChI InChI=1S/C19H25N3O2/c1-15-5-3-10-22(15)11-4-12-24-18-8-6-16(7-9-18)17-13-19(23)21(2)20-14-17/h6-9,13-15H,3-5,10-12H2,1-2H3/t15-/m1/s1
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1.90n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]NAMH from human cloned 5HT3 receptor expressed in CHO cells


J Med Chem 55: 414-23 (2012)


Article DOI: 10.1021/jm201295j
BindingDB Entry DOI: 10.7270/Q2S46SFR
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50360899
PNG
(CHEMBL1935110)
Show SMILES C[C@@H]1CCCN1CCCOc1ccc(cc1)C1=NNC(=O)C(C)C1
Show InChI InChI=1S/C19H27N3O2/c1-14-13-18(20-21-19(14)23)16-6-8-17(9-7-16)24-12-4-11-22-10-3-5-15(22)2/h6-9,14-15H,3-5,10-13H2,1-2H3,(H,21,23)/t14?,15-/m1/s1
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1.90n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]NAMH from human histamine H3 receptor expressed in CHO cells


Bioorg Med Chem Lett 22: 194-8 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.037
BindingDB Entry DOI: 10.7270/Q25Q4WJV
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50364957
PNG
(CHEMBL1950643)
Show SMILES O=c1ccc(n[nH]1)-c1ccc(OC2CCN(CC2)C2CCC2)cc1
Show InChI InChI=1S/C19H23N3O2/c23-19-9-8-18(20-21-19)14-4-6-16(7-5-14)24-17-10-12-22(13-11-17)15-2-1-3-15/h4-9,15,17H,1-3,10-13H2,(H,21,23)
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1.90n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]NAMH from human histamine H3 receptor expressed in CHO cells


Bioorg Med Chem Lett 22: 1504-9 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.026
BindingDB Entry DOI: 10.7270/Q2W37WSF
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50384928
PNG
(CHEMBL2036635)
Show SMILES C[C@@H]1CCCN1CCCOc1ccc(cc1)C(=O)CN1CCN(CC1)C(=O)c1ccccc1
Show InChI InChI=1S/C27H35N3O3/c1-22-7-5-14-29(22)15-6-20-33-25-12-10-23(11-13-25)26(31)21-28-16-18-30(19-17-28)27(32)24-8-3-2-4-9-24/h2-4,8-13,22H,5-7,14-21H2,1H3/t22-/m1/s1
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1.90n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]NAMH from human histamine H3 receptor expressed in CHO cells


Bioorg Med Chem Lett 22: 2807-10 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.081
BindingDB Entry DOI: 10.7270/Q26M37VX
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50363320
PNG
(CHEMBL1945844)
Show SMILES O=c1cc(cn[nH]1)-c1ccc(OC2CCN(CC2)C2CCC2)cc1
Show InChI InChI=1S/C19H23N3O2/c23-19-12-15(13-20-21-19)14-4-6-17(7-5-14)24-18-8-10-22(11-9-18)16-2-1-3-16/h4-7,12-13,16,18H,1-3,8-11H2,(H,21,23)
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2n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in CHO cells


Bioorg Med Chem Lett 22: 1073-7 (2012)


Article DOI: 10.1016/j.bmcl.2011.11.118
BindingDB Entry DOI: 10.7270/Q2K64JHT
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50355120
PNG
(CHEMBL1835782)
Show SMILES C[C@@H]1CCCN1CCCOc1ccc(cc1)-c1nn(C)c(=O)c2CCCc12
Show InChI InChI=1S/C22H29N3O2/c1-16-6-4-13-25(16)14-5-15-27-18-11-9-17(10-12-18)21-19-7-3-8-20(19)22(26)24(2)23-21/h9-12,16H,3-8,13-15H2,1-2H3/t16-/m1/s1
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2n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-NAMH from rat histamine H3 receptor expressed in CHO cells


Bioorg Med Chem Lett 21: 6126-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.08.045
BindingDB Entry DOI: 10.7270/Q2T72JFP
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50379619
PNG
(CHEMBL2013052)
Show SMILES CC(C)C(=O)N1CCC(CC1)Oc1ccc2OC3(CCN(CC3)C3CCC3)CCc2c1
Show InChI InChI=1S/C26H38N2O3/c1-19(2)25(29)28-14-9-22(10-15-28)30-23-6-7-24-20(18-23)8-11-26(31-24)12-16-27(17-13-26)21-4-3-5-21/h6-7,18-19,21-22H,3-5,8-17H2,1-2H3
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2n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-N-alpha-methylhistamine from human cloned histamine H3 receptor expressed in CHO cells


Bioorg Med Chem Lett 22: 2151-3 (2012)


Article DOI: 10.1016/j.bmcl.2012.01.139
BindingDB Entry DOI: 10.7270/Q2736RX9
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50350021
PNG
(CHEMBL1813067)
Show SMILES C[C@@H]1CCCN1CCCOc1ccc(cc1)-c1ccc(=O)[nH]n1
Show InChI InChI=1S/C18H23N3O2/c1-14-4-2-11-21(14)12-3-13-23-16-7-5-15(6-8-16)17-9-10-18(22)20-19-17/h5-10,14H,2-4,11-13H2,1H3,(H,20,22)/t14-/m1/s1
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2n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]NAMH from human cloned histamine 3 receptor expressed in CHO cells


Bioorg Med Chem Lett 21: 5493-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.108
BindingDB Entry DOI: 10.7270/Q2KP8359
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM50364323
PNG
(CHEMBL1949928)
Show SMILES Clc1cccc(c1Cl)S(=O)(=O)c1ccc2[C@@H]3CCNC[C@@H]3Oc2c1
Show InChI InChI=1S/C17H15Cl2NO3S/c18-13-2-1-3-16(17(13)19)24(21,22)10-4-5-11-12-6-7-20-9-15(12)23-14(11)8-10/h1-5,8,12,15,20H,6-7,9H2/t12-,15-/m0/s1
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2n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human recombinant 5HT6 receptor


Bioorg Med Chem Lett 22: 1421-6 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.026
BindingDB Entry DOI: 10.7270/Q20Z73R1
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50350021
PNG
(CHEMBL1813067)
Show SMILES C[C@@H]1CCCN1CCCOc1ccc(cc1)-c1ccc(=O)[nH]n1
Show InChI InChI=1S/C18H23N3O2/c1-14-4-2-11-21(14)12-3-13-23-16-7-5-15(6-8-16)17-9-10-18(22)20-19-17/h5-10,14H,2-4,11-13H2,1H3,(H,20,22)/t14-/m1/s1
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2n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]-NAMH from human histamine H3 receptor expressed in CHO cells


Bioorg Med Chem Lett 21: 6126-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.08.045
BindingDB Entry DOI: 10.7270/Q2T72JFP
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50350021
PNG
(CHEMBL1813067)
Show SMILES C[C@@H]1CCCN1CCCOc1ccc(cc1)-c1ccc(=O)[nH]n1
Show InChI InChI=1S/C18H23N3O2/c1-14-4-2-11-21(14)12-3-13-23-16-7-5-15(6-8-16)17-9-10-18(22)20-19-17/h5-10,14H,2-4,11-13H2,1H3,(H,20,22)/t14-/m1/s1
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2n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]NAMH from human histamine H3 receptor expressed in CHO cells


J Med Chem 54: 4781-92 (2011)


Article DOI: 10.1021/jm200401v
BindingDB Entry DOI: 10.7270/Q2W66MRB
More data for this
Ligand-Target Pair
Calpain1/2


(Homo sapiens (Human))
BDBM50065404
PNG
((R)-N-((S)-5-Benzenesulfonylamino-1-formyl-pentyl)...)
Show SMILES CS(=O)(=O)N[C@H](COCc1ccccc1)C(=O)N[C@@H](CCCCNS(=O)(=O)c1ccccc1)C=O
Show InChI InChI=1S/C23H31N3O7S2/c1-34(29,30)26-22(18-33-17-19-10-4-2-5-11-19)23(28)25-20(16-27)12-8-9-15-24-35(31,32)21-13-6-3-7-14-21/h2-7,10-11,13-14,16,20,22,24,26H,8-9,12,15,17-18H2,1H3,(H,25,28)/t20-,22+/m0/s1
PDB
MMDB

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2n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibitory activity against recombinant human Calpain-I receptor


J Med Chem 41: 2663-6 (1998)


Article DOI: 10.1021/jm980035y
BindingDB Entry DOI: 10.7270/Q2S46SNF
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50363320
PNG
(CHEMBL1945844)
Show SMILES O=c1cc(cn[nH]1)-c1ccc(OC2CCN(CC2)C2CCC2)cc1
Show InChI InChI=1S/C19H23N3O2/c23-19-12-15(13-20-21-19)14-4-6-17(7-5-14)24-18-8-10-22(11-9-18)16-2-1-3-16/h4-7,12-13,16,18H,1-3,8-11H2,(H,21,23)
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2n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]N-alpha-methylhistamine from rat histamine H3 receptor expressed in CHO cells


Bioorg Med Chem Lett 22: 1073-7 (2012)


Article DOI: 10.1016/j.bmcl.2011.11.118
BindingDB Entry DOI: 10.7270/Q2K64JHT
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50360897
PNG
(CHEMBL1935108)
Show SMILES C[C@@H]1CCCN1CCCOc1ccc(cc1)C1=NN(Cc2ccccc2)C(=O)CC1
Show InChI InChI=1S/C25H31N3O2/c1-20-7-5-16-27(20)17-6-18-30-23-12-10-22(11-13-23)24-14-15-25(29)28(26-24)19-21-8-3-2-4-9-21/h2-4,8-13,20H,5-7,14-19H2,1H3/t20-/m1/s1
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2n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]NAMH from human histamine H3 receptor expressed in CHO cells


Bioorg Med Chem Lett 22: 194-8 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.037
BindingDB Entry DOI: 10.7270/Q25Q4WJV
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50358574
PNG
(CHEMBL1923735)
Show SMILES C[C@@H]1CCCN1CCCOc1ccc(cc1)-c1ccc(=O)n(Cc2ccccc2)c1
Show InChI InChI=1S/C26H30N2O2/c1-21-7-5-16-27(21)17-6-18-30-25-13-10-23(11-14-25)24-12-15-26(29)28(20-24)19-22-8-3-2-4-9-22/h2-4,8-15,20-21H,5-7,16-19H2,1H3/t21-/m1/s1
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2n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]NAMH from human histamine H3 receptor expressed in CHO cells


Bioorg Med Chem Lett 21: 7076-80 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.091
BindingDB Entry DOI: 10.7270/Q26H4HVK
More data for this
Ligand-Target Pair
Serotonin 3 (5-HT3) receptor


(Homo sapiens (Human))
BDBM50365253
PNG
(CHEMBL1958326)
Show SMILES C[C@@H]1CCCN1CCCOc1ccc(cc1)-c1cc(=O)n(C)nc1C
Show InChI InChI=1S/C20H27N3O2/c1-15-6-4-11-23(15)12-5-13-25-18-9-7-17(8-10-18)19-14-20(24)22(3)21-16(19)2/h7-10,14-15H,4-6,11-13H2,1-3H3/t15-/m1/s1
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2n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]NAMH from human cloned 5HT3 receptor expressed in CHO cells


J Med Chem 55: 414-23 (2012)


Article DOI: 10.1021/jm201295j
BindingDB Entry DOI: 10.7270/Q2S46SFR
More data for this
Ligand-Target Pair
Serotonin 3 (5-HT3) receptor


(Homo sapiens (Human))
BDBM50350021
PNG
(CHEMBL1813067)
Show SMILES C[C@@H]1CCCN1CCCOc1ccc(cc1)-c1ccc(=O)[nH]n1
Show InChI InChI=1S/C18H23N3O2/c1-14-4-2-11-21(14)12-3-13-23-16-7-5-15(6-8-16)17-9-10-18(22)20-19-17/h5-10,14H,2-4,11-13H2,1H3,(H,20,22)/t14-/m1/s1
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2n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]NAMH from human cloned 5HT3 receptor expressed in CHO cells


J Med Chem 55: 414-23 (2012)


Article DOI: 10.1021/jm201295j
BindingDB Entry DOI: 10.7270/Q2S46SFR
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (human))
BDBM50384939
PNG
(CHEMBL2036650)
Show SMILES C[C@@H]1CCCN1CCCOc1ccc(cc1)C(=O)CN1CCN(CC1)C(=O)c1ccco1
Show InChI InChI=1S/C25H33N3O4/c1-20-5-2-11-27(20)12-4-18-31-22-9-7-21(8-10-22)23(29)19-26-13-15-28(16-14-26)25(30)24-6-3-17-32-24/h3,6-10,17,20H,2,4-5,11-16,18-19H2,1H3/t20-/m1/s1
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2n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]NAMH from human histamine H3 receptor expressed in CHO cells


Bioorg Med Chem Lett 22: 2807-10 (2012)


Article DOI: 10.1016/j.bmcl.2012.02.081
BindingDB Entry DOI: 10.7270/Q26M37VX
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM50361055
PNG
(CHEMBL1935599)
Show SMILES Fc1cccc(c1)S(=O)(=O)c1ccc2c3CCNC4(CCOCC4)c3oc2c1
Show InChI InChI=1S/C21H20FNO4S/c22-14-2-1-3-15(12-14)28(24,25)16-4-5-17-18-6-9-23-21(7-10-26-11-8-21)20(18)27-19(17)13-16/h1-5,12-13,23H,6-11H2
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2.10n/an/an/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from full length human 5HT6 receptor


Bioorg Med Chem Lett 22: 120-3 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.050
BindingDB Entry DOI: 10.7270/Q24Q7VFX
More data for this
Ligand-Target Pair
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