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Compile Data Set for Download or QSAR

Found 13 hits from Cephalon, Inc.   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
26S proteosome


(Homo sapiens (Human))
BDBM50031442
PNG
(1N-[4-amino(nitroimino)methylamino-1-(1-formyl-3-m...)
Show SMILES CC(C)CC(NC(=O)C(CCCN=C(N)N[N+]([O-])=O)NC(=O)C(CCCCCCCCN1C(=O)c2ccccc2C1=O)C1CCCC1)C=O
Show InChI InChI=1/C35H53N7O7/c1-24(2)22-26(23-43)38-32(45)30(19-13-20-37-35(36)40-42(48)49)39-31(44)27(25-14-8-9-15-25)16-7-5-3-4-6-12-21-41-33(46)28-17-10-11-18-29(28)34(41)47/h10-11,17-18,23-27,30H,3-9,12-16,19-22H2,1-2H3,(H,38,45)(H,39,44)(H3,36,37,40)
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n/an/a 2n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibitory activity against 20S proteasome from human liver and brain


J Med Chem 38: 2276-7 (1995)

More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Rattus norvegicus)
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/s2
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n/an/a 3n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of protein kinase C


J Med Chem 40: 2994-6 (1997)

More data for this
Ligand-Target Pair
26S proteosome


(Homo sapiens (Human))
BDBM50031440
PNG
(1N-[4-amino(nitroimino)methylamino-1-(1-formyl-3-m...)
Show SMILES CC(C)CC(NC(=O)C(CCCN=C(N)N[N+]([O-])=O)NC(=O)C(CCCCCCCCC#N)C1CCCC1)C=O
Show InChI InChI=1/C28H49N7O5/c1-21(2)19-23(20-36)32-27(38)25(16-12-18-31-28(30)34-35(39)40)33-26(37)24(22-13-9-10-14-22)15-8-6-4-3-5-7-11-17-29/h20-25H,3-16,18-19H2,1-2H3,(H,32,38)(H,33,37)(H3,30,31,34)
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n/an/a 6n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibitory activity against 20S proteasome from human liver and brain


J Med Chem 38: 2276-7 (1995)

More data for this
Ligand-Target Pair
26S proteosome


(Homo sapiens (Human))
BDBM50470197
PNG
(CHEMBL2114122)
Show SMILES COC(=O)CCCCCCCC(=O)N[C@@H](CCC\N=C(/N)NS(=O)(=O)c1c(C)c(C)c2OC(C)(C)CCc2c1C)C(=O)NC(CC(C)C)C=O
Show InChI InChI=1S/C36H59N5O8S/c1-23(2)21-27(22-42)39-34(45)29(40-30(43)16-12-10-9-11-13-17-31(44)48-8)15-14-20-38-35(37)41-50(46,47)33-25(4)24(3)32-28(26(33)5)18-19-36(6,7)49-32/h22-23,27,29H,9-21H2,1-8H3,(H,39,45)(H,40,43)(H3,37,38,41)/t27?,29-/m0/s1
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n/an/a 20n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibitory activity against 20S proteasome from human liver and brain


J Med Chem 38: 2276-7 (1995)

More data for this
Ligand-Target Pair
26S proteosome


(Homo sapiens (Human))
BDBM50470199
PNG
(CHEMBL76284)
Show SMILES COC(=O)CCCCCCCC(=O)NC(CCC\N=C(/N)N[N+]([O-])=O)C(=O)NC(CC(C)C)C=O
Show InChI InChI=1S/C22H40N6O7/c1-16(2)14-17(15-29)25-21(32)18(10-9-13-24-22(23)27-28(33)34)26-19(30)11-7-5-4-6-8-12-20(31)35-3/h15-18H,4-14H2,1-3H3,(H,25,32)(H,26,30)(H3,23,24,27)
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n/an/a 40n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibitory activity against 20S proteasome from human liver and brain


J Med Chem 38: 2276-7 (1995)

More data for this
Ligand-Target Pair
26S proteosome


(Homo sapiens (Human))
BDBM50470198
PNG
(CHEMBL73602)
Show SMILES COC(=O)CCCCCCCC(=O)NC(CCC\N=C(/N)NS(=O)(=O)c1c(C)cc(OC)c(C)c1C)C(=O)NC(CC(C)C)C=O
Show InChI InChI=1S/C32H53N5O8S/c1-21(2)18-25(20-38)35-31(41)26(36-28(39)15-11-9-8-10-12-16-29(40)45-7)14-13-17-34-32(33)37-46(42,43)30-22(3)19-27(44-6)23(4)24(30)5/h19-21,25-26H,8-18H2,1-7H3,(H,35,41)(H,36,39)(H3,33,34,37)
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n/an/a 95n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibitory activity against 20S proteasome from human liver and brain


J Med Chem 38: 2276-7 (1995)

More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Rattus norvegicus)
BDBM6760
PNG
((+)-K-252a | CHEMBL281948 | K-252a | methyl (15S,1...)
Show SMILES COC(=O)[C@@]1(O)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31)/t18-,26+,27+/s2
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n/an/a 250n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of protein kinase C


J Med Chem 40: 2994-6 (1997)

More data for this
Ligand-Target Pair
26S proteosome


(Homo sapiens (Human))
BDBM50470200
PNG
(CHEMBL2369773)
Show SMILES COC(=O)CCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C30H45N5O10/c1-18(2)26(35-28(41)21(12-14-24(37)38)32-23(36)13-15-25(39)45-3)29(42)33-20(11-7-8-16-31)27(40)34-22(30(43)44)17-19-9-5-4-6-10-19/h4-6,9-10,18,20-22,26H,7-8,11-17,31H2,1-3H3,(H,32,36)(H,33,42)(H,34,40)(H,35,41)(H,37,38)(H,43,44)/t20-,21-,22-,26-/m0/s1
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n/an/a 1.00E+3n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibitory activity against 20S proteasome from human liver and brain


J Med Chem 38: 2276-7 (1995)

More data for this
Ligand-Target Pair
26S proteosome


(Homo sapiens (Human))
BDBM50470201
PNG
(CHEMBL406736)
Show SMILES COC(=O)CCCCCCCC(=O)N[C@H](CCC\N=C(/N)NS(=O)(=O)c1c(C)c(C)c2OC(C)(C)CCc2c1C)C(=O)NC(CC(C)C)C=O
Show InChI InChI=1S/C36H59N5O8S/c1-23(2)21-27(22-42)39-34(45)29(40-30(43)16-12-10-9-11-13-17-31(44)48-8)15-14-20-38-35(37)41-50(46,47)33-25(4)24(3)32-28(26(33)5)18-19-36(6,7)49-32/h22-23,27,29H,9-21H2,1-8H3,(H,39,45)(H,40,43)(H3,37,38,41)/t27?,29-/m1/s1
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n/an/a>3.00E+3n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibitory activity against 20S proteasome from human liver and brain


J Med Chem 38: 2276-7 (1995)

More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Rattus norvegicus)
BDBM50471337
PNG
(CHEMBL99748)
Show SMILES O=C1Cc2c(N1)c1c3ccccc3oc1c1[nH]c3ccccc3c21
Show InChI InChI=1S/C20H12N2O2/c23-15-9-12-16-10-5-1-3-7-13(10)21-19(16)20-17(18(12)22-15)11-6-2-4-8-14(11)24-20/h1-8,21H,9H2,(H,22,23)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of protein kinase C


J Med Chem 40: 2994-6 (1997)

More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Rattus norvegicus)
BDBM50471336
PNG
(CHEMBL419726)
Show SMILES O=C1Cc2c(N1)c1c3ccccc3sc1c1[nH]c3ccccc3c21
Show InChI InChI=1S/C20H12N2OS/c23-15-9-12-16-10-5-1-3-7-13(10)21-19(16)20-17(18(12)22-15)11-6-2-4-8-14(11)24-20/h1-8,21H,9H2,(H,22,23)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of protein kinase C


J Med Chem 40: 2994-6 (1997)

More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Rattus norvegicus)
BDBM50471335
PNG
(CHEMBL103544)
Show SMILES O=C1Cc2c(N1)c1c3ccccc3[nH]c1c1[nH]c3ccccc3c21
Show InChI InChI=1S/C20H11N3O/c24-15-9-12-16-10-5-1-3-7-13(10)21-19(16)20-17(18(12)23-15)11-6-2-4-8-14(11)22-20/h1-8H,9H2,(H,23,24)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of protein kinase C


J Med Chem 40: 2994-6 (1997)

More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Rattus norvegicus)
BDBM50471334
PNG
(CHEMBL99749)
Show SMILES O=C1Cc2c(N1)c-1c(Cc3ccccc-13)c1[nH]c3ccccc3c21
Show InChI InChI=1S/C21H14N2O/c24-17-10-15-19-13-7-3-4-8-16(13)22-20(19)14-9-11-5-1-2-6-12(11)18(14)21(15)23-17/h1-8,22H,9-10H2,(H,23,24)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of protein kinase C


J Med Chem 40: 2994-6 (1997)

More data for this
Ligand-Target Pair