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Compile Data Set for Download or QSAR

Found 16 hits from ChemRF Laboratories   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50091030
PNG
(CHEMBL3582033)
Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4ccn(c4C(F)(F)F)-c4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C13H21N3/c1-2-5-16-6-3-4-10-7-12-11(8-13(10)16)9-14-15-12/h9-10,13H,2-8H2,1H3,(H,14,15)/p+1/t10-,13-/m1/s1
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n/an/a 10n/an/an/an/an/an/a



ChemRF Laboratories

Curated by ChEMBL


Assay Description
Inhibition of RON (unknown origin) transfected in 293T cells assessed as autophosporylated level by ELISA


Bioorg Med Chem Lett 25: 2527-31 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.056
BindingDB Entry DOI: 10.7270/Q21C1ZMR
More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50317323
PNG
(CHEMBL1094718 | N-(3-fluoro-4-(2-(1-methyl-1H-imid...)
Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4C(F)(F)F)-c4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C28H18F4N6O2S/c1-37-14-21(34-15-37)24-12-20-25(41-24)23(9-10-33-20)40-22-8-7-16(11-19(22)29)36-27(39)18-13-35-38(26(18)28(30,31)32)17-5-3-2-4-6-17/h2-15H,1H3,(H,36,39)
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n/an/a 12n/an/an/an/an/an/a



ChemRF Laboratories

Curated by ChEMBL


Assay Description
Inhibition of RON (unknown origin) transfected in 293T cells assessed as autophosporylated level by ELISA


Bioorg Med Chem Lett 25: 2527-31 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.056
BindingDB Entry DOI: 10.7270/Q21C1ZMR
More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50090969
PNG
(CHEMBL3582034)
Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4ncn(c4C(F)(F)F)-c4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C28H18F4N6O2S/c1-37-13-20(34-14-37)23-12-19-25(41-23)22(9-10-33-19)40-21-8-7-16(11-18(21)29)36-27(39)24-26(28(30,31)32)38(15-35-24)17-5-3-2-4-6-17/h2-15H,1H3,(H,36,39)
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n/an/a 13n/an/an/an/an/an/a



ChemRF Laboratories

Curated by ChEMBL


Assay Description
Inhibition of RON (unknown origin) transfected in 293T cells assessed as autophosporylated level by ELISA


Bioorg Med Chem Lett 25: 2527-31 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.056
BindingDB Entry DOI: 10.7270/Q21C1ZMR
More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50317324
PNG
(CHEMBL1087984 | N-(4-(6,7-dimethoxyquinolin-4-ylox...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4C(F)(F)F)-c4ccccc4)cc3F)c2cc1OC
Show InChI InChI=1S/C28H20F4N4O4/c1-38-24-13-18-21(14-25(24)39-2)33-11-10-22(18)40-23-9-8-16(12-20(23)29)35-27(37)19-15-34-36(26(19)28(30,31)32)17-6-4-3-5-7-17/h3-15H,1-2H3,(H,35,37)
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n/an/a 16n/an/an/an/an/an/a



ChemRF Laboratories

Curated by ChEMBL


Assay Description
Inhibition of RON (unknown origin) transfected in 293T cells assessed as autophosporylated level by ELISA


Bioorg Med Chem Lett 25: 2527-31 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.056
BindingDB Entry DOI: 10.7270/Q21C1ZMR
More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50090968
PNG
(CHEMBL3582035)
Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4nnn(c4C(F)(F)F)-c4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C27H17F4N7O2S/c1-37-13-19(33-14-37)22-12-18-24(41-22)21(9-10-32-18)40-20-8-7-15(11-17(20)28)34-26(39)23-25(27(29,30)31)38(36-35-23)16-5-3-2-4-6-16/h2-14H,1H3,(H,34,39)
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n/an/a 17n/an/an/an/an/an/a



ChemRF Laboratories

Curated by ChEMBL


Assay Description
Inhibition of RON (unknown origin) transfected in 293T cells assessed as autophosporylated level by ELISA


Bioorg Med Chem Lett 25: 2527-31 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.056
BindingDB Entry DOI: 10.7270/Q21C1ZMR
More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50317323
PNG
(CHEMBL1094718 | N-(3-fluoro-4-(2-(1-methyl-1H-imid...)
Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4C(F)(F)F)-c4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C28H18F4N6O2S/c1-37-14-21(34-15-37)24-12-20-25(41-24)23(9-10-33-20)40-22-8-7-16(11-19(22)29)36-27(39)18-13-35-38(26(18)28(30,31)32)17-5-3-2-4-6-17/h2-15H,1H3,(H,36,39)
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n/an/a 30n/an/an/an/an/an/a



ChemRF Laboratories

Curated by ChEMBL


Assay Description
Inhibition of RON phosphorylation in human PC3 cells


Bioorg Med Chem Lett 25: 2527-31 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.056
BindingDB Entry DOI: 10.7270/Q21C1ZMR
More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50317323
PNG
(CHEMBL1094718 | N-(3-fluoro-4-(2-(1-methyl-1H-imid...)
Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4C(F)(F)F)-c4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C28H18F4N6O2S/c1-37-14-21(34-15-37)24-12-20-25(41-24)23(9-10-33-20)40-22-8-7-16(11-19(22)29)36-27(39)18-13-35-38(26(18)28(30,31)32)17-5-3-2-4-6-17/h2-15H,1H3,(H,36,39)
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n/an/a 30n/an/an/an/an/an/a



ChemRF Laboratories

Curated by ChEMBL


Assay Description
Inhibition of RON phosphorylation in human HT29 cells


Bioorg Med Chem Lett 25: 2527-31 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.056
BindingDB Entry DOI: 10.7270/Q21C1ZMR
More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50090966
PNG
(CHEMBL3582037)
Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4C(F)(F)F)-c4ccc(F)cc4)cc3F)c2s1
Show InChI InChI=1S/C28H17F5N6O2S/c1-38-13-21(35-14-38)24-11-20-25(42-24)23(8-9-34-20)41-22-7-4-16(10-19(22)30)37-27(40)18-12-36-39(26(18)28(31,32)33)17-5-2-15(29)3-6-17/h2-14H,1H3,(H,37,40)
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n/an/a 44n/an/an/an/an/an/a



ChemRF Laboratories

Curated by ChEMBL


Assay Description
Inhibition of RON (unknown origin) transfected in 293T cells assessed as autophosporylated level by ELISA


Bioorg Med Chem Lett 25: 2527-31 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.056
BindingDB Entry DOI: 10.7270/Q21C1ZMR
More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50090967
PNG
(CHEMBL3582036)
Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4cn(nc4C(F)(F)F)-c4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C28H18F4N6O2S/c1-37-14-21(34-15-37)24-12-20-25(41-24)23(9-10-33-20)40-22-8-7-16(11-19(22)29)35-27(39)18-13-38(17-5-3-2-4-6-17)36-26(18)28(30,31)32/h2-15H,1H3,(H,35,39)
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n/an/a 95n/an/an/an/an/an/a



ChemRF Laboratories

Curated by ChEMBL


Assay Description
Inhibition of RON (unknown origin) transfected in 293T cells assessed as autophosporylated level by ELISA


Bioorg Med Chem Lett 25: 2527-31 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.056
BindingDB Entry DOI: 10.7270/Q21C1ZMR
More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50091026
PNG
(CHEMBL3580678)
Show SMILES CN(C(=O)c1cnn(c1C(F)(F)F)-c1ccccc1)c1ccc(Oc2ccnc3cc(sc23)-c2cn(C)cn2)c(F)c1
Show InChI InChI=1S/C26H31NO3/c1-17-23-13-18-9-10-21(28)14-22(18)25(17,2)11-12-27(23)16-20-15-26(20,24(29)30-3)19-7-5-4-6-8-19/h4-10,14,17,20,23,28H,11-13,15-16H2,1-3H3/t17?,20?,23?,25-,26+/m1/s1
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n/an/a 580n/an/an/an/an/an/a



ChemRF Laboratories

Curated by ChEMBL


Assay Description
Inhibition of RON (unknown origin) transfected in 293T cells assessed as autophosporylated level by ELISA


Bioorg Med Chem Lett 25: 2527-31 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.056
BindingDB Entry DOI: 10.7270/Q21C1ZMR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50090968
PNG
(CHEMBL3582035)
Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4nnn(c4C(F)(F)F)-c4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C27H17F4N7O2S/c1-37-13-19(33-14-37)22-12-18-24(41-22)21(9-10-32-18)40-20-8-7-15(11-17(20)28)34-26(39)23-25(27(29,30)31)38(36-35-23)16-5-3-2-4-6-16/h2-14H,1H3,(H,34,39)
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n/an/a 670n/an/an/an/an/an/a



ChemRF Laboratories

Curated by ChEMBL


Assay Description
Inhibition of phosphorylation of c-Met in human MKN45 cells


Bioorg Med Chem Lett 25: 2527-31 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.056
BindingDB Entry DOI: 10.7270/Q21C1ZMR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50317324
PNG
(CHEMBL1087984 | N-(4-(6,7-dimethoxyquinolin-4-ylox...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4C(F)(F)F)-c4ccccc4)cc3F)c2cc1OC
Show InChI InChI=1S/C28H20F4N4O4/c1-38-24-13-18-21(14-25(24)39-2)33-11-10-22(18)40-23-9-8-16(12-20(23)29)35-27(37)19-15-34-36(26(19)28(30,31)32)17-6-4-3-5-7-17/h3-15H,1-2H3,(H,35,37)
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n/an/a 1.06E+3n/an/an/an/an/an/a



ChemRF Laboratories

Curated by ChEMBL


Assay Description
Inhibition of phosphorylation of c-Met in human MKN45 cells


Bioorg Med Chem Lett 25: 2527-31 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.056
BindingDB Entry DOI: 10.7270/Q21C1ZMR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50090969
PNG
(CHEMBL3582034)
Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4ncn(c4C(F)(F)F)-c4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C28H18F4N6O2S/c1-37-13-20(34-14-37)23-12-19-25(41-23)22(9-10-33-19)40-21-8-7-16(11-18(21)29)36-27(39)24-26(28(30,31)32)38(15-35-24)17-5-3-2-4-6-17/h2-15H,1H3,(H,36,39)
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n/an/a 2.40E+3n/an/an/an/an/an/a



ChemRF Laboratories

Curated by ChEMBL


Assay Description
Inhibition of phosphorylation of c-Met in human MKN45 cells


Bioorg Med Chem Lett 25: 2527-31 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.056
BindingDB Entry DOI: 10.7270/Q21C1ZMR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50090967
PNG
(CHEMBL3582036)
Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4cn(nc4C(F)(F)F)-c4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C28H18F4N6O2S/c1-37-14-21(34-15-37)24-12-20-25(41-24)23(9-10-33-20)40-22-8-7-16(11-19(22)29)35-27(39)18-13-38(17-5-3-2-4-6-17)36-26(18)28(30,31)32/h2-15H,1H3,(H,35,39)
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n/an/a 3.77E+3n/an/an/an/an/an/a



ChemRF Laboratories

Curated by ChEMBL


Assay Description
Inhibition of phosphorylation of c-Met in human MKN45 cells


Bioorg Med Chem Lett 25: 2527-31 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.056
BindingDB Entry DOI: 10.7270/Q21C1ZMR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50090966
PNG
(CHEMBL3582037)
Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4C(F)(F)F)-c4ccc(F)cc4)cc3F)c2s1
Show InChI InChI=1S/C28H17F5N6O2S/c1-38-13-21(35-14-38)24-11-20-25(42-24)23(8-9-34-20)41-22-7-4-16(10-19(22)30)37-27(40)18-12-36-39(26(18)28(31,32)33)17-5-2-15(29)3-6-17/h2-14H,1H3,(H,37,40)
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n/an/a 4.37E+3n/an/an/an/an/an/a



ChemRF Laboratories

Curated by ChEMBL


Assay Description
Inhibition of phosphorylation of c-Met in human MKN45 cells


Bioorg Med Chem Lett 25: 2527-31 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.056
BindingDB Entry DOI: 10.7270/Q21C1ZMR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50317323
PNG
(CHEMBL1094718 | N-(3-fluoro-4-(2-(1-methyl-1H-imid...)
Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4C(F)(F)F)-c4ccccc4)cc3F)c2s1
Show InChI InChI=1S/C28H18F4N6O2S/c1-37-14-21(34-15-37)24-12-20-25(41-24)23(9-10-33-20)40-22-8-7-16(11-19(22)29)36-27(39)18-13-35-38(26(18)28(30,31)32)17-5-3-2-4-6-17/h2-15H,1H3,(H,36,39)
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n/an/a 6.87E+3n/an/an/an/an/an/a



ChemRF Laboratories

Curated by ChEMBL


Assay Description
Inhibition of phosphorylation of c-Met in human MKN45 cells


Bioorg Med Chem Lett 25: 2527-31 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.056
BindingDB Entry DOI: 10.7270/Q21C1ZMR
More data for this
Ligand-Target Pair