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Compile Data Set for Download or QSAR

Found 152 hits from Chemical Diversity, Inc   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM9504
PNG
(2-[(pyridin-4-ylmethyl)amino]-N-(quinolin-3-yl)ben...)
Show SMILES O=C(Nc1cnc2ccccc2c1)c1ccccc1NCc1ccncc1
Show InChI InChI=1S/C22H18N4O/c27-22(26-18-13-17-5-1-3-7-20(17)25-15-18)19-6-2-4-8-21(19)24-14-16-9-11-23-12-10-16/h1-13,15,24H,14H2,(H,26,27)
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n/an/a 15n/an/an/an/a7.522



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM21
PNG
(6-[(4R,5S,6S,7R)-4,7-dibenzyl-3-(5-carboxypentyl)-...)
Show SMILES COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCN(C)CC1
Show InChI InChI=1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27)
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n/an/a 22n/an/an/an/a7.522



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM9543
PNG
(((pyridin-4-yl)ethyl)pyridine 25 | N-[4-(chlorodif...)
Show SMILES FC(F)(Cl)Oc1ccc(Nc2nnc(o2)-c2cccnc2CCc2ccncc2)cc1
Show InChI InChI=1S/C21H16ClF2N5O2/c22-21(23,24)31-16-6-4-15(5-7-16)27-20-29-28-19(30-20)17-2-1-11-26-18(17)8-3-14-9-12-25-13-10-14/h1-2,4-7,9-13H,3,8H2,(H,27,29)
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n/an/a 31n/an/an/an/an/an/a



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 1913-9 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2C827H5
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM9503
PNG
(2-[(pyridin-4-ylmethyl)amino]-N-[3-(trifluoromethy...)
Show SMILES FC(F)(F)c1cccc(NC(=O)c2ccccc2NCc2ccncc2)c1
Show InChI InChI=1S/C20H16F3N3O/c21-20(22,23)15-4-3-5-16(12-15)26-19(27)17-6-1-2-7-18(17)25-13-14-8-10-24-11-9-14/h1-12,25H,13H2,(H,26,27)
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n/an/a 32n/an/an/an/a7.522



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM9537
PNG
(((pyridin-4-yl)ethyl)pyridine 19 | N-(4-tert-butyl...)
Show SMILES CC(C)(C)c1ccc(Nc2nnc(o2)-c2cccnc2CCc2ccncc2)cc1
Show InChI InChI=1S/C24H25N5O/c1-24(2,3)18-7-9-19(10-8-18)27-23-29-28-22(30-23)20-5-4-14-26-21(20)11-6-17-12-15-25-16-13-17/h4-5,7-10,12-16H,6,11H2,1-3H3,(H,27,29)
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n/an/a 43n/an/an/an/an/an/a



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 1913-9 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2C827H5
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM9544
PNG
(((pyridin-4-yl)ethyl)pyridine 26 | 5-{2-[2-(pyridi...)
Show SMILES FC(F)(F)Oc1ccc(Nc2nnc(o2)-c2cccnc2CCc2ccncc2)cc1
Show InChI InChI=1S/C21H16F3N5O2/c22-21(23,24)31-16-6-4-15(5-7-16)27-20-29-28-19(30-20)17-2-1-11-26-18(17)8-3-14-9-12-25-13-10-14/h1-2,4-7,9-13H,3,8H2,(H,27,29)
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n/an/a 44n/an/an/an/an/an/a



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 1913-9 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2C827H5
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM9538
PNG
(((pyridin-4-yl)ethyl)pyridine 20 | N-[4-(propan-2-...)
Show SMILES CC(C)c1ccc(Nc2nnc(o2)-c2cccnc2CCc2ccncc2)cc1
Show InChI InChI=1S/C23H23N5O/c1-16(2)18-6-8-19(9-7-18)26-23-28-27-22(29-23)20-4-3-13-25-21(20)10-5-17-11-14-24-15-12-17/h3-4,6-9,11-16H,5,10H2,1-2H3,(H,26,28)
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n/an/a 51n/an/an/an/an/an/a



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 1913-9 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2C827H5
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM4851
PNG
((4-chlorophenyl)-[4-(4-pyridylmethyl)phthalazin-1-...)
Show SMILES Clc1ccc(Nc2nnc(Cc3ccncc3)c3ccccc23)cc1
Show InChI InChI=1S/C20H15ClN4/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24-25-20)13-14-9-11-22-12-10-14/h1-12H,13H2,(H,23,25)
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n/an/a 54n/an/an/an/a7.522



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM9545
PNG
(((pyridin-4-yl)ethyl)pyridine 27 | 5-{2-[2-(pyridi...)
Show SMILES FC(F)(F)c1ccc(Nc2nnc(o2)-c2cccnc2CCc2ccncc2)cc1
Show InChI InChI=1S/C21H16F3N5O/c22-21(23,24)15-4-6-16(7-5-15)27-20-29-28-19(30-20)17-2-1-11-26-18(17)8-3-14-9-12-25-13-10-14/h1-2,4-7,9-13H,3,8H2,(H,27,29)
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n/an/a 58n/an/an/an/an/an/a



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 1913-9 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2C827H5
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM9523
PNG
(((pyridin-4-yl)ethyl)pyridine 5 | 5-{2-[2-(pyridin...)
Show SMILES FC(F)(F)c1cccc(Nc2nnc(o2)-c2cccnc2CCc2ccncc2)c1
Show InChI InChI=1S/C21H16F3N5O/c22-21(23,24)15-3-1-4-16(13-15)27-20-29-28-19(30-20)17-5-2-10-26-18(17)7-6-14-8-11-25-12-9-14/h1-5,8-13H,6-7H2,(H,27,29)
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n/an/a 64n/an/an/an/a7.522



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 1913-9 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2C827H5
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM9560
PNG
(((pyridin-4-yl)ethyl)pyridine 42 | N-(3,4-dimethox...)
Show SMILES COc1ccc(Nc2nnc(o2)-c2cccnc2CCc2ccncc2)cc1OC
Show InChI InChI=1S/C22H21N5O3/c1-28-19-8-6-16(14-20(19)29-2)25-22-27-26-21(30-22)17-4-3-11-24-18(17)7-5-15-9-12-23-13-10-15/h3-4,6,8-14H,5,7H2,1-2H3,(H,25,27)
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n/an/a 67n/an/an/an/an/an/a



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 1913-9 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2C827H5
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM9552
PNG
(((pyridin-4-yl)ethyl)pyridine 34 | 5-{2-[2-(pyridi...)
Show SMILES FC(F)(F)Oc1cccc(Nc2nnc(o2)-c2cccnc2CCc2ccncc2)c1
Show InChI InChI=1S/C21H16F3N5O2/c22-21(23,24)31-16-4-1-3-15(13-16)27-20-29-28-19(30-20)17-5-2-10-26-18(17)7-6-14-8-11-25-12-9-14/h1-5,8-13H,6-7H2,(H,27,29)
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n/an/a 69n/an/an/an/an/an/a



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 1913-9 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2C827H5
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM9559
PNG
(((pyridin-4-yl)ethyl)pyridine 41 | N-(3,4-dichloro...)
Show SMILES Clc1ccc(Nc2nnc(o2)-c2cccnc2CCc2ccncc2)cc1Cl
Show InChI InChI=1S/C20H15Cl2N5O/c21-16-5-4-14(12-17(16)22)25-20-27-26-19(28-20)15-2-1-9-24-18(15)6-3-13-7-10-23-11-8-13/h1-2,4-5,7-12H,3,6H2,(H,25,27)
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n/an/a 79n/an/an/an/an/an/a



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 1913-9 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2C827H5
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM9562
PNG
(((pyridin-4-yl)ethyl)pyridine 44 | N-(2H-1,3-benzo...)
Show SMILES C(Cc1ncccc1-c1nnc(NCc2ccc3OCOc3c2)o1)c1ccncc1
Show InChI InChI=1S/C22H19N5O3/c1-2-17(18(24-9-1)5-3-15-7-10-23-11-8-15)21-26-27-22(30-21)25-13-16-4-6-19-20(12-16)29-14-28-19/h1-2,4,6-12H,3,5,13-14H2,(H,25,27)
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n/an/a 85n/an/an/an/an/an/a



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 1913-9 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2C827H5
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM9561
PNG
(((pyridin-4-yl)ethyl)pyridine 43 | N-[4-methyl-3-(...)
Show SMILES Cc1ccc(Nc2nnc(o2)-c2cccnc2CCc2ccncc2)cc1C(F)(F)F
Show InChI InChI=1S/C22H18F3N5O/c1-14-4-6-16(13-18(14)22(23,24)25)28-21-30-29-20(31-21)17-3-2-10-27-19(17)7-5-15-8-11-26-12-9-15/h2-4,6,8-13H,5,7H2,1H3,(H,28,30)
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n/an/a 87n/an/an/an/an/an/a



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 1913-9 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2C827H5
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM21
PNG
(6-[(4R,5S,6S,7R)-4,7-dibenzyl-3-(5-carboxypentyl)-...)
Show SMILES COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCN(C)CC1
Show InChI InChI=1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27)
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n/an/a 100n/an/an/an/an/an/a



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM9505
PNG
(N-(Aryl)-thiazole-5-carboxamide 17 | N-[4-(chlorod...)
Show SMILES FC(F)(Cl)Oc1ccc(NC(=O)c2scnc2CCc2ccncc2)cc1
Show InChI InChI=1S/C18H14ClF2N3O2S/c19-18(20,21)26-14-4-2-13(3-5-14)24-17(25)16-15(23-11-27-16)6-1-12-7-9-22-10-8-12/h2-5,7-11H,1,6H2,(H,24,25)
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n/an/a 110n/an/an/an/an/an/a



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM9497
PNG
(N-(4-tert-butylphenyl)-4-[2-(pyridin-4-yl)ethyl]-1...)
Show SMILES CC(C)(C)c1ccc(NC(=O)c2scnc2CCc2ccncc2)cc1
Show InChI InChI=1S/C21H23N3OS/c1-21(2,3)16-5-7-17(8-6-16)24-20(25)19-18(23-14-26-19)9-4-15-10-12-22-13-11-15/h5-8,10-14H,4,9H2,1-3H3,(H,24,25)
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n/an/a 110n/an/an/an/a7.522



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM9561
PNG
(((pyridin-4-yl)ethyl)pyridine 43 | N-[4-methyl-3-(...)
Show SMILES Cc1ccc(Nc2nnc(o2)-c2cccnc2CCc2ccncc2)cc1C(F)(F)F
Show InChI InChI=1S/C22H18F3N5O/c1-14-4-6-16(13-18(14)22(23,24)25)28-21-30-29-20(31-21)17-3-2-10-27-19(17)7-5-15-8-11-26-12-9-15/h2-4,6,8-13H,5,7H2,1H3,(H,28,30)
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Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 1913-9 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2C827H5
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM9492
PNG
(N-(4-chlorophenyl)-4-[2-(pyridin-4-yl)ethyl]-1,3-t...)
Show SMILES Clc1ccc(NC(=O)c2scnc2CCc2ccncc2)cc1
Show InChI InChI=1S/C17H14ClN3OS/c18-13-2-4-14(5-3-13)21-17(22)16-15(20-11-23-16)6-1-12-7-9-19-10-8-12/h2-5,7-11H,1,6H2,(H,21,22)
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n/an/a 130n/an/an/an/a7.522



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM4851
PNG
((4-chlorophenyl)-[4-(4-pyridylmethyl)phthalazin-1-...)
Show SMILES Clc1ccc(Nc2nnc(Cc3ccncc3)c3ccccc23)cc1
Show InChI InChI=1S/C20H15ClN4/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24-25-20)13-14-9-11-22-12-10-14/h1-12H,13H2,(H,23,25)
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n/an/a 140n/an/an/an/an/an/a



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM9501
PNG
(N-(Aryl)-thiazole-5-carboxamide 15 | N-[4-(propan-...)
Show SMILES CC(C)c1ccc(NC(=O)c2scnc2CCc2ccncc2)cc1
Show InChI InChI=1S/C20H21N3OS/c1-14(2)16-4-6-17(7-5-16)23-20(24)19-18(22-13-25-19)8-3-15-9-11-21-12-10-15/h4-7,9-14H,3,8H2,1-2H3,(H,23,24)
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n/an/a 140n/an/an/an/a7.522



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM9562
PNG
(((pyridin-4-yl)ethyl)pyridine 44 | N-(2H-1,3-benzo...)
Show SMILES C(Cc1ncccc1-c1nnc(NCc2ccc3OCOc3c2)o1)c1ccncc1
Show InChI InChI=1S/C22H19N5O3/c1-2-17(18(24-9-1)5-3-15-7-10-23-11-8-15)21-26-27-22(30-21)25-13-16-4-6-19-20(12-16)29-14-28-19/h1-2,4,6-12H,3,5,13-14H2,(H,25,27)
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Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 1913-9 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2C827H5
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM9504
PNG
(2-[(pyridin-4-ylmethyl)amino]-N-(quinolin-3-yl)ben...)
Show SMILES O=C(Nc1cnc2ccccc2c1)c1ccccc1NCc1ccncc1
Show InChI InChI=1S/C22H18N4O/c27-22(26-18-13-17-5-1-3-7-20(17)25-15-18)19-6-2-4-8-21(19)24-14-16-9-11-23-12-10-16/h1-13,15,24H,14H2,(H,26,27)
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n/an/a 160n/an/an/an/an/an/a



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM9503
PNG
(2-[(pyridin-4-ylmethyl)amino]-N-[3-(trifluoromethy...)
Show SMILES FC(F)(F)c1cccc(NC(=O)c2ccccc2NCc2ccncc2)c1
Show InChI InChI=1S/C20H16F3N3O/c21-20(22,23)15-4-3-5-16(12-15)26-19(27)17-6-1-2-7-18(17)25-13-14-8-10-24-11-9-14/h1-12,25H,13H2,(H,26,27)
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n/an/a 170n/an/an/an/an/an/a



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM9556
PNG
(((pyridin-4-yl)ethyl)pyridine 38 | N-(3-methoxyphe...)
Show SMILES COc1cccc(Nc2nnc(o2)-c2cccnc2CCc2ccncc2)c1
Show InChI InChI=1S/C21H19N5O2/c1-27-17-5-2-4-16(14-17)24-21-26-25-20(28-21)18-6-3-11-23-19(18)8-7-15-9-12-22-13-10-15/h2-6,9-14H,7-8H2,1H3,(H,24,26)
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Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 1913-9 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2C827H5
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM9560
PNG
(((pyridin-4-yl)ethyl)pyridine 42 | N-(3,4-dimethox...)
Show SMILES COc1ccc(Nc2nnc(o2)-c2cccnc2CCc2ccncc2)cc1OC
Show InChI InChI=1S/C22H21N5O3/c1-28-19-8-6-16(14-20(19)29-2)25-22-27-26-21(30-22)17-4-3-11-24-18(17)7-5-15-9-12-23-13-10-15/h3-4,6,8-14H,5,7H2,1-2H3,(H,25,27)
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n/an/a 180n/an/an/an/an/an/a



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 1913-9 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2C827H5
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM9513
PNG
(N-(3,4-dichlorophenyl)-4-[2-(pyridin-4-yl)ethyl]-1...)
Show SMILES Clc1ccc(NC(=O)c2scnc2CCc2ccncc2)cc1Cl
Show InChI InChI=1S/C17H13Cl2N3OS/c18-13-3-2-12(9-14(13)19)22-17(23)16-15(21-10-24-16)4-1-11-5-7-20-8-6-11/h2-3,5-10H,1,4H2,(H,22,23)
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n/an/a 180n/an/an/an/an/an/a



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM9539
PNG
(((pyridin-4-yl)ethyl)pyridine 21 | N-(4-tert-butyl...)
Show SMILES CC(C)(C)c1ccc(Nc2nnc(o2)-c2ccncc2CCc2ccncc2)cc1
Show InChI InChI=1S/C24H25N5O/c1-24(2,3)19-6-8-20(9-7-19)27-23-29-28-22(30-23)21-12-15-26-16-18(21)5-4-17-10-13-25-14-11-17/h6-16H,4-5H2,1-3H3,(H,27,29)
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n/an/a 190n/an/an/an/an/an/a



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 1913-9 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2C827H5
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM9523
PNG
(((pyridin-4-yl)ethyl)pyridine 5 | 5-{2-[2-(pyridin...)
Show SMILES FC(F)(F)c1cccc(Nc2nnc(o2)-c2cccnc2CCc2ccncc2)c1
Show InChI InChI=1S/C21H16F3N5O/c22-21(23,24)15-3-1-4-16(13-15)27-20-29-28-19(30-20)17-5-2-10-26-18(17)7-6-14-8-11-25-12-9-14/h1-5,8-13H,6-7H2,(H,27,29)
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n/an/a 220n/an/an/an/an/an/a



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 1913-9 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2C827H5
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM9539
PNG
(((pyridin-4-yl)ethyl)pyridine 21 | N-(4-tert-butyl...)
Show SMILES CC(C)(C)c1ccc(Nc2nnc(o2)-c2ccncc2CCc2ccncc2)cc1
Show InChI InChI=1S/C24H25N5O/c1-24(2,3)19-6-8-20(9-7-19)27-23-29-28-22(30-23)21-12-15-26-16-18(21)5-4-17-10-13-25-14-11-17/h6-16H,4-5H2,1-3H3,(H,27,29)
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Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 1913-9 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2C827H5
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM9546
PNG
(((pyridin-4-yl)ethyl)pyridine 28 | N-[4-(chlorodif...)
Show SMILES FC(F)(Cl)Oc1ccc(Nc2nnc(o2)-c2ccncc2CCc2ccncc2)cc1
Show InChI InChI=1S/C21H16ClF2N5O2/c22-21(23,24)31-17-5-3-16(4-6-17)27-20-29-28-19(30-20)18-9-12-26-13-15(18)2-1-14-7-10-25-11-8-14/h3-13H,1-2H2,(H,27,29)
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n/an/a 220n/an/an/an/an/an/a



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 1913-9 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2C827H5
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM9540
PNG
(((pyridin-4-yl)ethyl)pyridine 22 | N-[4-(propan-2-...)
Show SMILES CC(C)c1ccc(Nc2nnc(o2)-c2ccncc2CCc2ccncc2)cc1
Show InChI InChI=1S/C23H23N5O/c1-16(2)18-5-7-20(8-6-18)26-23-28-27-22(29-23)21-11-14-25-15-19(21)4-3-17-9-12-24-13-10-17/h5-16H,3-4H2,1-2H3,(H,26,28)
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Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 1913-9 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2C827H5
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM9552
PNG
(((pyridin-4-yl)ethyl)pyridine 34 | 5-{2-[2-(pyridi...)
Show SMILES FC(F)(F)Oc1cccc(Nc2nnc(o2)-c2cccnc2CCc2ccncc2)c1
Show InChI InChI=1S/C21H16F3N5O2/c22-21(23,24)31-16-4-1-3-15(13-16)27-20-29-28-19(30-20)17-5-2-10-26-18(17)7-6-14-8-11-25-12-9-14/h1-5,8-13H,6-7H2,(H,27,29)
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n/an/a 260n/an/an/an/an/an/a



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 1913-9 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2C827H5
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM9540
PNG
(((pyridin-4-yl)ethyl)pyridine 22 | N-[4-(propan-2-...)
Show SMILES CC(C)c1ccc(Nc2nnc(o2)-c2ccncc2CCc2ccncc2)cc1
Show InChI InChI=1S/C23H23N5O/c1-16(2)18-5-7-20(8-6-18)26-23-28-27-22(29-23)21-11-14-25-15-19(21)4-3-17-9-12-24-13-10-17/h5-16H,3-4H2,1-2H3,(H,26,28)
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n/an/a 270n/an/an/an/an/an/a



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 1913-9 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2C827H5
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM9559
PNG
(((pyridin-4-yl)ethyl)pyridine 41 | N-(3,4-dichloro...)
Show SMILES Clc1ccc(Nc2nnc(o2)-c2cccnc2CCc2ccncc2)cc1Cl
Show InChI InChI=1S/C20H15Cl2N5O/c21-16-5-4-14(12-17(16)22)25-20-27-26-19(28-20)15-2-1-9-24-18(15)6-3-13-7-10-23-11-8-13/h1-2,4-5,7-12H,3,6H2,(H,25,27)
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n/an/a 270n/an/an/an/an/an/a



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 1913-9 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2C827H5
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM9515
PNG
(N-(Aryl)-thiazole-5-carboxamide 27 | N-[4-chloro-3...)
Show SMILES FC(F)(F)c1cc(NC(=O)c2scnc2CCc2ccncc2)ccc1Cl
Show InChI InChI=1S/C18H13ClF3N3OS/c19-14-3-2-12(9-13(14)18(20,21)22)25-17(26)16-15(24-10-27-16)4-1-11-5-7-23-8-6-11/h2-3,5-10H,1,4H2,(H,25,26)
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Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM9548
PNG
(((pyridin-4-yl)ethyl)pyridine 30 | 5-{3-[2-(pyridi...)
Show SMILES FC(F)(F)c1ccc(Nc2nnc(o2)-c2ccncc2CCc2ccncc2)cc1
Show InChI InChI=1S/C21H16F3N5O/c22-21(23,24)16-3-5-17(6-4-16)27-20-29-28-19(30-20)18-9-12-26-13-15(18)2-1-14-7-10-25-11-8-14/h3-13H,1-2H2,(H,27,29)
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n/an/a 290n/an/an/an/an/an/a



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Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 1913-9 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2C827H5
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM9517
PNG
(N-(2-fluoro-4-methylphenyl)-4-[2-(pyridin-4-yl)eth...)
Show SMILES Cc1ccc(NC(=O)c2scnc2CCc2ccncc2)c(F)c1
Show InChI InChI=1S/C18H16FN3OS/c1-12-2-4-15(14(19)10-12)22-18(23)17-16(21-11-24-17)5-3-13-6-8-20-9-7-13/h2,4,6-11H,3,5H2,1H3,(H,22,23)
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n/an/a 310n/an/an/an/an/an/a



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Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM9492
PNG
(N-(4-chlorophenyl)-4-[2-(pyridin-4-yl)ethyl]-1,3-t...)
Show SMILES Clc1ccc(NC(=O)c2scnc2CCc2ccncc2)cc1
Show InChI InChI=1S/C17H14ClN3OS/c18-13-2-4-14(5-3-13)21-17(22)16-15(20-11-23-16)6-1-12-7-9-19-10-8-12/h2-5,7-11H,1,6H2,(H,21,22)
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n/an/a 310n/an/an/an/an/an/a



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM9541
PNG
(((pyridin-4-yl)ethyl)pyridine 23 | N-(4-tert-butyl...)
Show SMILES CC(C)(C)c1ccc(Nc2nnc(o2)-c2cnccc2CCc2ccncc2)cc1
Show InChI InChI=1S/C24H25N5O/c1-24(2,3)19-6-8-20(9-7-19)27-23-29-28-22(30-23)21-16-26-15-12-18(21)5-4-17-10-13-25-14-11-17/h6-16H,4-5H2,1-3H3,(H,27,29)
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n/an/a 310n/an/an/an/an/an/a



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 1913-9 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2C827H5
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM9545
PNG
(((pyridin-4-yl)ethyl)pyridine 27 | 5-{2-[2-(pyridi...)
Show SMILES FC(F)(F)c1ccc(Nc2nnc(o2)-c2cccnc2CCc2ccncc2)cc1
Show InChI InChI=1S/C21H16F3N5O/c22-21(23,24)15-4-6-16(7-5-15)27-20-29-28-19(30-20)17-2-1-11-26-18(17)8-3-14-9-12-25-13-10-14/h1-2,4-7,9-13H,3,8H2,(H,27,29)
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n/an/a 320n/an/an/an/an/an/a



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 1913-9 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2C827H5
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM9547
PNG
(((pyridin-4-yl)ethyl)pyridine 29 | 5-{3-[2-(pyridi...)
Show SMILES FC(F)(F)Oc1ccc(Nc2nnc(o2)-c2ccncc2CCc2ccncc2)cc1
Show InChI InChI=1S/C21H16F3N5O2/c22-21(23,24)31-17-5-3-16(4-6-17)27-20-29-28-19(30-20)18-9-12-26-13-15(18)2-1-14-7-10-25-11-8-14/h3-13H,1-2H2,(H,27,29)
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n/an/a 350n/an/an/an/an/an/a



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 1913-9 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2C827H5
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM9550
PNG
(((pyridin-4-yl)ethyl)pyridine 32 | 5-{4-[2-(pyridi...)
Show SMILES FC(F)(F)Oc1ccc(Nc2nnc(o2)-c2cnccc2CCc2ccncc2)cc1
Show InChI InChI=1S/C21H16F3N5O2/c22-21(23,24)31-17-5-3-16(4-6-17)27-20-29-28-19(30-20)18-13-26-12-9-15(18)2-1-14-7-10-25-11-8-14/h3-13H,1-2H2,(H,27,29)
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n/an/a 360n/an/an/an/an/an/a



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 1913-9 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2C827H5
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM9518
PNG
(N-(2H-1,3-benzodioxol-5-yl)-4-[2-(pyridin-4-yl)eth...)
Show SMILES O=C(Nc1ccc2OCOc2c1)c1scnc1CCc1ccncc1
Show InChI InChI=1S/C18H15N3O3S/c22-18(21-13-2-4-15-16(9-13)24-11-23-15)17-14(20-10-25-17)3-1-12-5-7-19-8-6-12/h2,4-10H,1,3,11H2,(H,21,22)
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n/an/a 370n/an/an/an/an/an/a



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 602-6 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.058
BindingDB Entry DOI: 10.7270/Q2H1307W
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM9535
PNG
(((pyridin-4-yl)ethyl)pyridine 17 | 5-{2-[2-(pyridi...)
Show SMILES C(Cc1ncccc1-c1nnc(Nc2cnc3ccccc3c2)o1)c1ccncc1
Show InChI InChI=1S/C23H18N6O/c1-2-6-20-17(4-1)14-18(15-26-20)27-23-29-28-22(30-23)19-5-3-11-25-21(19)8-7-16-9-12-24-13-10-16/h1-6,9-15H,7-8H2,(H,27,29)
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n/an/a 380n/an/an/an/a7.522



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 1913-9 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2C827H5
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM9549
PNG
(((pyridin-4-yl)ethyl)pyridine 31 | N-[4-(chlorodif...)
Show SMILES FC(F)(Cl)Oc1ccc(Nc2nnc(o2)-c2cnccc2CCc2ccncc2)cc1
Show InChI InChI=1S/C21H16ClF2N5O2/c22-21(23,24)31-17-5-3-16(4-6-17)27-20-29-28-19(30-20)18-13-26-12-9-15(18)2-1-14-7-10-25-11-8-14/h3-13H,1-2H2,(H,27,29)
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n/an/a 440n/an/an/an/an/an/a



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 1913-9 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2C827H5
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM9551
PNG
(((pyridin-4-yl)ethyl)pyridine 33 | 5-{4-[2-(pyridi...)
Show SMILES FC(F)(F)c1ccc(Nc2nnc(o2)-c2cnccc2CCc2ccncc2)cc1
Show InChI InChI=1S/C21H16F3N5O/c22-21(23,24)16-3-5-17(6-4-16)27-20-29-28-19(30-20)18-13-26-12-9-15(18)2-1-14-7-10-25-11-8-14/h3-13H,1-2H2,(H,27,29)
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n/an/a 440n/an/an/an/an/an/a



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 1913-9 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2C827H5
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM9535
PNG
(((pyridin-4-yl)ethyl)pyridine 17 | 5-{2-[2-(pyridi...)
Show SMILES C(Cc1ncccc1-c1nnc(Nc2cnc3ccccc3c2)o1)c1ccncc1
Show InChI InChI=1S/C23H18N6O/c1-2-6-20-17(4-1)14-18(15-26-20)27-23-29-28-22(30-23)19-5-3-11-25-21(19)8-7-16-9-12-24-13-10-16/h1-6,9-15H,7-8H2,(H,27,29)
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n/an/a 440n/an/an/an/an/an/a



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 1913-9 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2C827H5
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM9553
PNG
(((pyridin-4-yl)ethyl)pyridine 35 | 5-{3-[2-(pyridi...)
Show SMILES FC(F)(F)Oc1cccc(Nc2nnc(o2)-c2ccncc2CCc2ccncc2)c1
Show InChI InChI=1S/C21H16F3N5O2/c22-21(23,24)31-17-3-1-2-16(12-17)27-20-29-28-19(30-20)18-8-11-26-13-15(18)5-4-14-6-9-25-10-7-14/h1-3,6-13H,4-5H2,(H,27,29)
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n/an/a 470n/an/an/an/an/an/a



Chemical Diversity, Inc



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


Bioorg Med Chem Lett 16: 1913-9 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.090
BindingDB Entry DOI: 10.7270/Q2C827H5
More data for this
Ligand-Target Pair
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