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Compile Data Set for Download or QSAR

Found 457 hits from Chemical Diversity, Inc.   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50201397
PNG
(1-methyl-N-(3-methyl-4-(trifluoromethyl)phenyl)-4-...)
Show SMILES Cc1cc(NC(=O)c2c(NCc3ccncc3)ncn2C)ccc1C(F)(F)F
Show InChI InChI=1S/C19H18F3N5O/c1-12-9-14(3-4-15(12)19(20,21)22)26-18(28)16-17(25-11-27(16)2)24-10-13-5-7-23-8-6-13/h3-9,11,24H,10H2,1-2H3,(H,26,28)
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0.160n/an/an/an/an/an/an/an/a



Chemical Diversity, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 by [32P]ATP-competitive radioassay


Bioorg Med Chem Lett 17: 1369-75 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.087
BindingDB Entry DOI: 10.7270/Q2125S92
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50201363
PNG
(1-methyl-4-(pyridin-4-ylmethylamino)-N-(4-(trifluo...)
Show SMILES Cn1ncc(NCc2ccncc2)c1C(=O)Nc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C18H16F3N5O2/c1-26-16(15(11-24-26)23-10-12-6-8-22-9-7-12)17(27)25-13-2-4-14(5-3-13)28-18(19,20)21/h2-9,11,23H,10H2,1H3,(H,25,27)
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0.170n/an/an/an/an/an/an/an/a



Chemical Diversity, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 by [32P]ATP-competitive radioassay


Bioorg Med Chem Lett 17: 1369-75 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.087
BindingDB Entry DOI: 10.7270/Q2125S92
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50201394
PNG
(CHEMBL393779 | N-(4-tert-butylphenyl)-1-methyl-4-(...)
Show SMILES Cn1cnc(NCc2ccncc2)c1C(=O)Nc1ccc(cc1)C(C)(C)C
Show InChI InChI=1S/C21H25N5O/c1-21(2,3)16-5-7-17(8-6-16)25-20(27)18-19(24-14-26(18)4)23-13-15-9-11-22-12-10-15/h5-12,14,23H,13H2,1-4H3,(H,25,27)
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0.200n/an/an/an/an/an/an/an/a



Chemical Diversity, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 by [32P]ATP-competitive radioassay


Bioorg Med Chem Lett 17: 1369-75 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.087
BindingDB Entry DOI: 10.7270/Q2125S92
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50211992
PNG
(CHEMBL236419 | N-(4-(chlorodifluoromethoxy)phenyl)...)
Show SMILES FC(F)(Cl)Oc1cccc(NC(=O)c2ccnn2CCc2ccncc2)c1
Show InChI InChI=1S/C18H15ClF2N4O2/c19-18(20,21)27-15-3-1-2-14(12-15)24-17(26)16-6-10-23-25(16)11-7-13-4-8-22-9-5-13/h1-6,8-10,12H,7,11H2,(H,24,26)
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70n/an/an/an/an/an/an/an/a



Chemical Diversity, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 assessed as inhibition of phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 17: 3550-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.042
BindingDB Entry DOI: 10.7270/Q2MG7P6N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50211983
PNG
(1-(2-(pyridin-4-yl)ethyl)-N-(4-(trifluoromethoxy)p...)
Show SMILES FC(F)(F)Oc1ccc(NC(=O)c2ccnn2CCc2ccncc2)cc1
Show InChI InChI=1S/C18H15F3N4O2/c19-18(20,21)27-15-3-1-14(2-4-15)24-17(26)16-7-11-23-25(16)12-8-13-5-9-22-10-6-13/h1-7,9-11H,8,12H2,(H,24,26)
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80n/an/an/an/an/an/an/an/a



Chemical Diversity, Inc.

Curated by ChEMBL


Assay Description
Displacement of [32P]ATP from human VEGFR2 after 45 mins


Bioorg Med Chem Lett 17: 3550-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.042
BindingDB Entry DOI: 10.7270/Q2MG7P6N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50211992
PNG
(CHEMBL236419 | N-(4-(chlorodifluoromethoxy)phenyl)...)
Show SMILES FC(F)(Cl)Oc1cccc(NC(=O)c2ccnn2CCc2ccncc2)c1
Show InChI InChI=1S/C18H15ClF2N4O2/c19-18(20,21)27-15-3-1-2-14(12-15)24-17(26)16-6-10-23-25(16)11-7-13-4-8-22-9-5-13/h1-6,8-10,12H,7,11H2,(H,24,26)
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90n/an/an/an/an/an/an/an/a



Chemical Diversity, Inc.

Curated by ChEMBL


Assay Description
Displacement of [32P]ATP from human VEGFR2 after 45 mins


Bioorg Med Chem Lett 17: 3550-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.042
BindingDB Entry DOI: 10.7270/Q2MG7P6N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50211976
PNG
(CHEMBL397323 | N-(4-chlorophenyl)-1-(2-(pyridin-4-...)
Show SMILES Clc1ccc(NC(=O)c2ccnn2CCc2ccncc2)cc1
Show InChI InChI=1S/C17H15ClN4O/c18-14-1-3-15(4-2-14)21-17(23)16-7-11-20-22(16)12-8-13-5-9-19-10-6-13/h1-7,9-11H,8,12H2,(H,21,23)
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90n/an/an/an/an/an/an/an/a



Chemical Diversity, Inc.

Curated by ChEMBL


Assay Description
Displacement of [32P]ATP from human VEGFR2 after 45 mins


Bioorg Med Chem Lett 17: 3550-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.042
BindingDB Entry DOI: 10.7270/Q2MG7P6N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50211983
PNG
(1-(2-(pyridin-4-yl)ethyl)-N-(4-(trifluoromethoxy)p...)
Show SMILES FC(F)(F)Oc1ccc(NC(=O)c2ccnn2CCc2ccncc2)cc1
Show InChI InChI=1S/C18H15F3N4O2/c19-18(20,21)27-15-3-1-14(2-4-15)24-17(26)16-7-11-23-25(16)12-8-13-5-9-22-10-6-13/h1-7,9-11H,8,12H2,(H,24,26)
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90n/an/an/an/an/an/an/an/a



Chemical Diversity, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 assessed as inhibition of phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 17: 3550-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.042
BindingDB Entry DOI: 10.7270/Q2MG7P6N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50211976
PNG
(CHEMBL397323 | N-(4-chlorophenyl)-1-(2-(pyridin-4-...)
Show SMILES Clc1ccc(NC(=O)c2ccnn2CCc2ccncc2)cc1
Show InChI InChI=1S/C17H15ClN4O/c18-14-1-3-15(4-2-14)21-17(23)16-7-11-20-22(16)12-8-13-5-9-19-10-6-13/h1-7,9-11H,8,12H2,(H,21,23)
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110n/an/an/an/an/an/an/an/a



Chemical Diversity, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 assessed as inhibition of phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 17: 3550-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.042
BindingDB Entry DOI: 10.7270/Q2MG7P6N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50211979
PNG
(CHEMBL399605 | N-(4-tert-butylphenyl)-1-(2-(pyridi...)
Show SMILES CC(C)(C)c1ccc(NC(=O)c2ccnn2CCc2ccncc2)cc1
Show InChI InChI=1S/C21H24N4O/c1-21(2,3)17-4-6-18(7-5-17)24-20(26)19-10-14-23-25(19)15-11-16-8-12-22-13-9-16/h4-10,12-14H,11,15H2,1-3H3,(H,24,26)
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130n/an/an/an/an/an/an/an/a



Chemical Diversity, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 assessed as inhibition of phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 17: 3550-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.042
BindingDB Entry DOI: 10.7270/Q2MG7P6N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50211979
PNG
(CHEMBL399605 | N-(4-tert-butylphenyl)-1-(2-(pyridi...)
Show SMILES CC(C)(C)c1ccc(NC(=O)c2ccnn2CCc2ccncc2)cc1
Show InChI InChI=1S/C21H24N4O/c1-21(2,3)17-4-6-18(7-5-17)24-20(26)19-10-14-23-25(19)15-11-16-8-12-22-13-9-16/h4-10,12-14H,11,15H2,1-3H3,(H,24,26)
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140n/an/an/an/an/an/an/an/a



Chemical Diversity, Inc.

Curated by ChEMBL


Assay Description
Displacement of [32P]ATP from human VEGFR2 after 45 mins


Bioorg Med Chem Lett 17: 3550-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.042
BindingDB Entry DOI: 10.7270/Q2MG7P6N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50211972
PNG
(CHEMBL233823 | N-(3-chloro-4-(trifluoromethyl)phen...)
Show SMILES FC(F)(F)c1ccc(NC(=O)c2ccnn2CCc2ccncc2)cc1Cl
Show InChI InChI=1S/C18H14ClF3N4O/c19-15-11-13(1-2-14(15)18(20,21)22)25-17(27)16-5-9-24-26(16)10-6-12-3-7-23-8-4-12/h1-5,7-9,11H,6,10H2,(H,25,27)
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160n/an/an/an/an/an/an/an/a



Chemical Diversity, Inc.

Curated by ChEMBL


Assay Description
Displacement of [32P]ATP from human VEGFR2 after 45 mins


Bioorg Med Chem Lett 17: 3550-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.042
BindingDB Entry DOI: 10.7270/Q2MG7P6N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50211972
PNG
(CHEMBL233823 | N-(3-chloro-4-(trifluoromethyl)phen...)
Show SMILES FC(F)(F)c1ccc(NC(=O)c2ccnn2CCc2ccncc2)cc1Cl
Show InChI InChI=1S/C18H14ClF3N4O/c19-15-11-13(1-2-14(15)18(20,21)22)25-17(27)16-5-9-24-26(16)10-6-12-3-7-23-8-4-12/h1-5,7-9,11H,6,10H2,(H,25,27)
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170n/an/an/an/an/an/an/an/a



Chemical Diversity, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 assessed as inhibition of phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 17: 3550-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.042
BindingDB Entry DOI: 10.7270/Q2MG7P6N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM9504
PNG
(2-[(pyridin-4-ylmethyl)amino]-N-(quinolin-3-yl)ben...)
Show SMILES O=C(Nc1cnc2ccccc2c1)c1ccccc1NCc1ccncc1
Show InChI InChI=1S/C22H18N4O/c27-22(26-18-13-17-5-1-3-7-20(17)25-15-18)19-6-2-4-8-21(19)24-14-16-9-11-23-12-10-16/h1-13,15,24H,14H2,(H,26,27)
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n/an/a 15n/an/an/an/an/an/a



Chemical Diversity, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1 by HTRF assay


Bioorg Med Chem Lett 17: 1369-75 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.087
BindingDB Entry DOI: 10.7270/Q2125S92
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM9504
PNG
(2-[(pyridin-4-ylmethyl)amino]-N-(quinolin-3-yl)ben...)
Show SMILES O=C(Nc1cnc2ccccc2c1)c1ccccc1NCc1ccncc1
Show InChI InChI=1S/C22H18N4O/c27-22(26-18-13-17-5-1-3-7-20(17)25-15-18)19-6-2-4-8-21(19)24-14-16-9-11-23-12-10-16/h1-13,15,24H,14H2,(H,26,27)
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n/an/a 15n/an/an/an/an/an/a



Chemical Diversity, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 by enzymatic assay


Bioorg Med Chem Lett 16: 1440-4 (2006)


Article DOI: 10.1016/j.bmcl.2005.11.033
BindingDB Entry DOI: 10.7270/Q2NP240T
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50211983
PNG
(1-(2-(pyridin-4-yl)ethyl)-N-(4-(trifluoromethoxy)p...)
Show SMILES FC(F)(F)Oc1ccc(NC(=O)c2ccnn2CCc2ccncc2)cc1
Show InChI InChI=1S/C18H15F3N4O2/c19-18(20,21)27-15-3-1-14(2-4-15)24-17(26)16-7-11-23-25(16)12-8-13-5-9-22-10-6-13/h1-7,9-11H,8,12H2,(H,24,26)
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n/an/a 18n/an/an/an/an/an/a



Chemical Diversity, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 assessed as inhibition of phosphorylation in human 293 cells by cell-based ELISA


Bioorg Med Chem Lett 17: 3550-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.042
BindingDB Entry DOI: 10.7270/Q2MG7P6N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM4851
PNG
((4-chlorophenyl)-[4-(4-pyridylmethyl)phthalazin-1-...)
Show SMILES Clc1ccc(Nc2nnc(Cc3ccncc3)c3ccccc23)cc1
Show InChI InChI=1S/C20H15ClN4/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24-25-20)13-14-9-11-22-12-10-14/h1-12H,13H2,(H,23,25)
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n/an/a 21n/an/an/an/an/an/a



Chemical Diversity, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 in 293 adenovirus transfected kidney cells by cell-based ELISA assay


Bioorg Med Chem Lett 16: 1440-4 (2006)


Article DOI: 10.1016/j.bmcl.2005.11.033
BindingDB Entry DOI: 10.7270/Q2NP240T
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50211992
PNG
(CHEMBL236419 | N-(4-(chlorodifluoromethoxy)phenyl)...)
Show SMILES FC(F)(Cl)Oc1cccc(NC(=O)c2ccnn2CCc2ccncc2)c1
Show InChI InChI=1S/C18H15ClF2N4O2/c19-18(20,21)27-15-3-1-2-14(12-15)24-17(26)16-6-10-23-25(16)11-7-13-4-8-22-9-5-13/h1-6,8-10,12H,7,11H2,(H,24,26)
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n/an/a 21n/an/an/an/an/an/a



Chemical Diversity, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 assessed as inhibition of phosphorylation in human 293 cells by cell-based ELISA


Bioorg Med Chem Lett 17: 3550-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.042
BindingDB Entry DOI: 10.7270/Q2MG7P6N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM4851
PNG
((4-chlorophenyl)-[4-(4-pyridylmethyl)phthalazin-1-...)
Show SMILES Clc1ccc(Nc2nnc(Cc3ccncc3)c3ccccc23)cc1
Show InChI InChI=1S/C20H15ClN4/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24-25-20)13-14-9-11-22-12-10-14/h1-12H,13H2,(H,23,25)
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n/an/a 21n/an/an/an/an/an/a



Chemical Diversity, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 by cell-based assay


Bioorg Med Chem Lett 17: 1369-75 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.087
BindingDB Entry DOI: 10.7270/Q2125S92
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM21
PNG
(6-[(4R,5S,6S,7R)-4,7-dibenzyl-3-(5-carboxypentyl)-...)
Show SMILES COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCN(C)CC1
Show InChI InChI=1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27)
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n/an/a 22n/an/an/an/an/an/a



Chemical Diversity, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1 by HTRF assay


Bioorg Med Chem Lett 17: 1369-75 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.087
BindingDB Entry DOI: 10.7270/Q2125S92
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM21
PNG
(6-[(4R,5S,6S,7R)-4,7-dibenzyl-3-(5-carboxypentyl)-...)
Show SMILES COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCN(C)CC1
Show InChI InChI=1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27)
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n/an/a 22n/an/an/an/an/an/a



Chemical Diversity, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 by enzymatic assay


Bioorg Med Chem Lett 16: 1440-4 (2006)


Article DOI: 10.1016/j.bmcl.2005.11.033
BindingDB Entry DOI: 10.7270/Q2NP240T
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50211983
PNG
(1-(2-(pyridin-4-yl)ethyl)-N-(4-(trifluoromethoxy)p...)
Show SMILES FC(F)(F)Oc1ccc(NC(=O)c2ccnn2CCc2ccncc2)cc1
Show InChI InChI=1S/C18H15F3N4O2/c19-18(20,21)27-15-3-1-14(2-4-15)24-17(26)16-7-11-23-25(16)12-8-13-5-9-22-10-6-13/h1-7,9-11H,8,12H2,(H,24,26)
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n/an/a 28n/an/an/an/an/an/a



Chemical Diversity, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 assessed as inhibition of phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 17: 3550-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.042
BindingDB Entry DOI: 10.7270/Q2MG7P6N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM9503
PNG
(2-[(pyridin-4-ylmethyl)amino]-N-[3-(trifluoromethy...)
Show SMILES FC(F)(F)c1cccc(NC(=O)c2ccccc2NCc2ccncc2)c1
Show InChI InChI=1S/C20H16F3N3O/c21-20(22,23)15-4-3-5-16(12-15)26-19(27)17-6-1-2-7-18(17)25-13-14-8-10-24-11-9-14/h1-12,25H,13H2,(H,26,27)
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n/an/a 32n/an/an/an/an/an/a



Chemical Diversity, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 by enzymatic assay


Bioorg Med Chem Lett 16: 1440-4 (2006)


Article DOI: 10.1016/j.bmcl.2005.11.033
BindingDB Entry DOI: 10.7270/Q2NP240T
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM9503
PNG
(2-[(pyridin-4-ylmethyl)amino]-N-[3-(trifluoromethy...)
Show SMILES FC(F)(F)c1cccc(NC(=O)c2ccccc2NCc2ccncc2)c1
Show InChI InChI=1S/C20H16F3N3O/c21-20(22,23)15-4-3-5-16(12-15)26-19(27)17-6-1-2-7-18(17)25-13-14-8-10-24-11-9-14/h1-12,25H,13H2,(H,26,27)
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n/an/a 32n/an/an/an/an/an/a



Chemical Diversity, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1 by HTRF assay


Bioorg Med Chem Lett 17: 1369-75 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.087
BindingDB Entry DOI: 10.7270/Q2125S92
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50211979
PNG
(CHEMBL399605 | N-(4-tert-butylphenyl)-1-(2-(pyridi...)
Show SMILES CC(C)(C)c1ccc(NC(=O)c2ccnn2CCc2ccncc2)cc1
Show InChI InChI=1S/C21H24N4O/c1-21(2,3)17-4-6-18(7-5-17)24-20(26)19-10-14-23-25(19)15-11-16-8-12-22-13-9-16/h4-10,12-14H,11,15H2,1-3H3,(H,24,26)
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n/an/a 33n/an/an/an/an/an/a



Chemical Diversity, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 assessed as inhibition of phosphorylation in human 293 cells by cell-based ELISA


Bioorg Med Chem Lett 17: 3550-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.042
BindingDB Entry DOI: 10.7270/Q2MG7P6N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50211979
PNG
(CHEMBL399605 | N-(4-tert-butylphenyl)-1-(2-(pyridi...)
Show SMILES CC(C)(C)c1ccc(NC(=O)c2ccnn2CCc2ccncc2)cc1
Show InChI InChI=1S/C21H24N4O/c1-21(2,3)17-4-6-18(7-5-17)24-20(26)19-10-14-23-25(19)15-11-16-8-12-22-13-9-16/h4-10,12-14H,11,15H2,1-3H3,(H,24,26)
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n/an/a 42n/an/an/an/an/an/a



Chemical Diversity, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 assessed as inhibition of phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 17: 3550-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.042
BindingDB Entry DOI: 10.7270/Q2MG7P6N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50178528
PNG
(CHEMBL205127 | N-(4-chloro-3-(trifluoromethyl)phen...)
Show SMILES Cn1cnc(NCc2ccncc2)c1-c1nnc(Nc2ccc(Cl)c(c2)C(F)(F)F)o1
Show InChI InChI=1S/C19H15ClF3N7O/c1-30-10-26-16(25-9-11-4-6-24-7-5-11)15(30)17-28-29-18(31-17)27-12-2-3-14(20)13(8-12)19(21,22)23/h2-8,10,25H,9H2,1H3,(H,27,29)
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n/an/a 43n/an/an/an/an/an/a



Chemical Diversity, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 by enzymatic assay


Bioorg Med Chem Lett 16: 1440-4 (2006)


Article DOI: 10.1016/j.bmcl.2005.11.033
BindingDB Entry DOI: 10.7270/Q2NP240T
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50201357
PNG
(CHEMBL401041 | N-(4-tert-butylphenyl)-1-methyl-4-(...)
Show SMILES Cn1ncc(NCc2ccncc2)c1C(=O)Nc1ccc(cc1)C(C)(C)C
Show InChI InChI=1S/C21H25N5O/c1-21(2,3)16-5-7-17(8-6-16)25-20(27)19-18(14-24-26(19)4)23-13-15-9-11-22-12-10-15/h5-12,14,23H,13H2,1-4H3,(H,25,27)
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n/an/a 45n/an/an/an/an/an/a



Chemical Diversity, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 by cell-based assay


Bioorg Med Chem Lett 17: 1369-75 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.087
BindingDB Entry DOI: 10.7270/Q2125S92
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50178509
PNG
(5-(1-methyl-4-(pyridin-4-ylmethylamino)-1H-imidazo...)
Show SMILES Cn1cnc(NCc2ccncc2)c1-c1nnc(Nc2cccc(OC(F)(F)F)c2)o1
Show InChI InChI=1S/C19H16F3N7O2/c1-29-11-25-16(24-10-12-5-7-23-8-6-12)15(29)17-27-28-18(30-17)26-13-3-2-4-14(9-13)31-19(20,21)22/h2-9,11,24H,10H2,1H3,(H,26,28)
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n/an/a 46n/an/an/an/an/an/a



Chemical Diversity, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 by enzymatic assay


Bioorg Med Chem Lett 16: 1440-4 (2006)


Article DOI: 10.1016/j.bmcl.2005.11.033
BindingDB Entry DOI: 10.7270/Q2NP240T
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50212000
PNG
(1-(2-(pyridin-4-yl)ethyl)-N-(4-(trifluoromethyl)ph...)
Show SMILES FC(F)(F)c1ccc(NC(=O)c2ccnn2CCc2ccncc2)cc1
Show InChI InChI=1S/C18H15F3N4O/c19-18(20,21)14-1-3-15(4-2-14)24-17(26)16-7-11-23-25(16)12-8-13-5-9-22-10-6-13/h1-7,9-11H,8,12H2,(H,24,26)
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n/an/a 48n/an/an/an/an/an/a



Chemical Diversity, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 assessed as inhibition of phosphorylation in human 293 cells by cell-based ELISA


Bioorg Med Chem Lett 17: 3550-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.042
BindingDB Entry DOI: 10.7270/Q2MG7P6N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM9504
PNG
(2-[(pyridin-4-ylmethyl)amino]-N-(quinolin-3-yl)ben...)
Show SMILES O=C(Nc1cnc2ccccc2c1)c1ccccc1NCc1ccncc1
Show InChI InChI=1S/C22H18N4O/c27-22(26-18-13-17-5-1-3-7-20(17)25-15-18)19-6-2-4-8-21(19)24-14-16-9-11-23-12-10-16/h1-13,15,24H,14H2,(H,26,27)
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n/an/a 50n/an/an/an/an/an/a



Chemical Diversity, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 by cell-based assay


Bioorg Med Chem Lett 17: 1369-75 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.087
BindingDB Entry DOI: 10.7270/Q2125S92
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM9504
PNG
(2-[(pyridin-4-ylmethyl)amino]-N-(quinolin-3-yl)ben...)
Show SMILES O=C(Nc1cnc2ccccc2c1)c1ccccc1NCc1ccncc1
Show InChI InChI=1S/C22H18N4O/c27-22(26-18-13-17-5-1-3-7-20(17)25-15-18)19-6-2-4-8-21(19)24-14-16-9-11-23-12-10-16/h1-13,15,24H,14H2,(H,26,27)
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n/an/a 50n/an/an/an/an/an/a



Chemical Diversity, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 in 293 adenovirus transfected kidney cells by cell-based ELISA assay


Bioorg Med Chem Lett 16: 1440-4 (2006)


Article DOI: 10.1016/j.bmcl.2005.11.033
BindingDB Entry DOI: 10.7270/Q2NP240T
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50178519
PNG
(CHEMBL378592 | N-(3,4-dimethoxyphenyl)-5-(1-methyl...)
Show SMILES COc1ccc(Nc2nnc(o2)-c2c(NCc3ccncc3)ncn2C)cc1OC
Show InChI InChI=1S/C20H21N7O3/c1-27-12-23-18(22-11-13-6-8-21-9-7-13)17(27)19-25-26-20(30-19)24-14-4-5-15(28-2)16(10-14)29-3/h4-10,12,22H,11H2,1-3H3,(H,24,26)
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n/an/a 52n/an/an/an/an/an/a



Chemical Diversity, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 by enzymatic assay


Bioorg Med Chem Lett 16: 1440-4 (2006)


Article DOI: 10.1016/j.bmcl.2005.11.033
BindingDB Entry DOI: 10.7270/Q2NP240T
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50211981
PNG
(CHEMBL236420 | N-(4-isopropylphenyl)-1-(2-(pyridin...)
Show SMILES CC(C)c1ccc(NC(=O)c2ccnn2CCc2ccncc2)cc1
Show InChI InChI=1S/C20H22N4O/c1-15(2)17-3-5-18(6-4-17)23-20(25)19-9-13-22-24(19)14-10-16-7-11-21-12-8-16/h3-9,11-13,15H,10,14H2,1-2H3,(H,23,25)
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n/an/a 53n/an/an/an/an/an/a



Chemical Diversity, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 assessed as inhibition of phosphorylation in human 293 cells by cell-based ELISA


Bioorg Med Chem Lett 17: 3550-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.042
BindingDB Entry DOI: 10.7270/Q2MG7P6N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM4851
PNG
((4-chlorophenyl)-[4-(4-pyridylmethyl)phthalazin-1-...)
Show SMILES Clc1ccc(Nc2nnc(Cc3ccncc3)c3ccccc23)cc1
Show InChI InChI=1S/C20H15ClN4/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24-25-20)13-14-9-11-22-12-10-14/h1-12H,13H2,(H,23,25)
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n/an/a 54n/an/an/an/an/an/a



Chemical Diversity, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1 by HTRF assay


Bioorg Med Chem Lett 17: 1369-75 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.087
BindingDB Entry DOI: 10.7270/Q2125S92
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM4851
PNG
((4-chlorophenyl)-[4-(4-pyridylmethyl)phthalazin-1-...)
Show SMILES Clc1ccc(Nc2nnc(Cc3ccncc3)c3ccccc23)cc1
Show InChI InChI=1S/C20H15ClN4/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24-25-20)13-14-9-11-22-12-10-14/h1-12H,13H2,(H,23,25)
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n/an/a 54n/an/an/an/an/an/a



Chemical Diversity, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 by enzymatic assay


Bioorg Med Chem Lett 16: 1440-4 (2006)


Article DOI: 10.1016/j.bmcl.2005.11.033
BindingDB Entry DOI: 10.7270/Q2NP240T
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50201344
PNG
(CHEMBL238529 | N-(3,4-dimethoxyphenyl)-1-methyl-4-...)
Show SMILES COc1ccc(NC(=O)c2c(NCc3ccncc3)ncn2C)cc1OC
Show InChI InChI=1S/C19H21N5O3/c1-24-12-22-18(21-11-13-6-8-20-9-7-13)17(24)19(25)23-14-4-5-15(26-2)16(10-14)27-3/h4-10,12,21H,11H2,1-3H3,(H,23,25)
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n/an/a 57n/an/an/an/an/an/a



Chemical Diversity, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 by cell-based assay


Bioorg Med Chem Lett 17: 1369-75 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.087
BindingDB Entry DOI: 10.7270/Q2125S92
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50201397
PNG
(1-methyl-N-(3-methyl-4-(trifluoromethyl)phenyl)-4-...)
Show SMILES Cc1cc(NC(=O)c2c(NCc3ccncc3)ncn2C)ccc1C(F)(F)F
Show InChI InChI=1S/C19H18F3N5O/c1-12-9-14(3-4-15(12)19(20,21)22)26-18(28)16-17(25-11-27(16)2)24-10-13-5-7-23-8-6-13/h3-9,11,24H,10H2,1-2H3,(H,26,28)
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n/an/a 64n/an/an/an/an/an/a



Chemical Diversity, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 by cell-based assay


Bioorg Med Chem Lett 17: 1369-75 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.087
BindingDB Entry DOI: 10.7270/Q2125S92
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50178511
PNG
(CHEMBL203796 | N-(3-methoxyphenyl)-5-(1-methyl-4-(...)
Show SMILES COc1cccc(Nc2nnc(o2)-c2c(NCc3ccncc3)ncn2C)c1
Show InChI InChI=1S/C19H19N7O2/c1-26-12-22-17(21-11-13-6-8-20-9-7-13)16(26)18-24-25-19(28-18)23-14-4-3-5-15(10-14)27-2/h3-10,12,21H,11H2,1-2H3,(H,23,25)
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n/an/a 64n/an/an/an/an/an/a



Chemical Diversity, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 in 293 adenovirus transfected kidney cells by cell-based ELISA assay


Bioorg Med Chem Lett 16: 1440-4 (2006)


Article DOI: 10.1016/j.bmcl.2005.11.033
BindingDB Entry DOI: 10.7270/Q2NP240T
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50201363
PNG
(1-methyl-4-(pyridin-4-ylmethylamino)-N-(4-(trifluo...)
Show SMILES Cn1ncc(NCc2ccncc2)c1C(=O)Nc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C18H16F3N5O2/c1-26-16(15(11-24-26)23-10-12-6-8-22-9-7-12)17(27)25-13-2-4-14(5-3-13)28-18(19,20)21/h2-9,11,23H,10H2,1H3,(H,25,27)
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n/an/a 64n/an/an/an/an/an/a



Chemical Diversity, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 by cell-based assay


Bioorg Med Chem Lett 17: 1369-75 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.087
BindingDB Entry DOI: 10.7270/Q2125S92
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50201394
PNG
(CHEMBL393779 | N-(4-tert-butylphenyl)-1-methyl-4-(...)
Show SMILES Cn1cnc(NCc2ccncc2)c1C(=O)Nc1ccc(cc1)C(C)(C)C
Show InChI InChI=1S/C21H25N5O/c1-21(2,3)16-5-7-17(8-6-16)25-20(27)18-19(24-14-26(18)4)23-13-15-9-11-22-12-10-15/h5-12,14,23H,13H2,1-4H3,(H,25,27)
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n/an/a 64n/an/an/an/an/an/a



Chemical Diversity, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 by cell-based assay


Bioorg Med Chem Lett 17: 1369-75 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.087
BindingDB Entry DOI: 10.7270/Q2125S92
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50178524
PNG
(5-(1-methyl-4-(pyridin-4-ylmethylamino)-1H-imidazo...)
Show SMILES Cn1cnc(NCc2ccncc2)c1-c1nnc(Nc2ccc(OC(F)(F)F)cc2)o1
Show InChI InChI=1S/C19H16F3N7O2/c1-29-11-25-16(24-10-12-6-8-23-9-7-12)15(29)17-27-28-18(30-17)26-13-2-4-14(5-3-13)31-19(20,21)22/h2-9,11,24H,10H2,1H3,(H,26,28)
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n/an/a 66n/an/an/an/an/an/a



Chemical Diversity, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 in 293 adenovirus transfected kidney cells by cell-based ELISA assay


Bioorg Med Chem Lett 16: 1440-4 (2006)


Article DOI: 10.1016/j.bmcl.2005.11.033
BindingDB Entry DOI: 10.7270/Q2NP240T
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50212000
PNG
(1-(2-(pyridin-4-yl)ethyl)-N-(4-(trifluoromethyl)ph...)
Show SMILES FC(F)(F)c1ccc(NC(=O)c2ccnn2CCc2ccncc2)cc1
Show InChI InChI=1S/C18H15F3N4O/c19-18(20,21)14-1-3-15(4-2-14)24-17(26)16-7-11-23-25(16)12-8-13-5-9-22-10-6-13/h1-7,9-11H,8,12H2,(H,24,26)
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n/an/a 69n/an/an/an/an/an/a



Chemical Diversity, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 assessed as inhibition of phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 17: 3550-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.042
BindingDB Entry DOI: 10.7270/Q2MG7P6N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50201382
PNG
(1-methyl-N-(3-methyl-4-(trifluoromethyl)phenyl)-4-...)
Show SMILES Cc1cc(NC(=O)c2c(NCc3ccncc3)cnn2C)ccc1C(F)(F)F
Show InChI InChI=1S/C19H18F3N5O/c1-12-9-14(3-4-15(12)19(20,21)22)26-18(28)17-16(11-25-27(17)2)24-10-13-5-7-23-8-6-13/h3-9,11,24H,10H2,1-2H3,(H,26,28)
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n/an/a 69n/an/an/an/an/an/a



Chemical Diversity, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 by cell-based assay


Bioorg Med Chem Lett 17: 1369-75 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.087
BindingDB Entry DOI: 10.7270/Q2125S92
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50178526
PNG
(5-(1-methyl-4-(pyridin-4-ylmethylamino)-1H-imidazo...)
Show SMILES Cn1cnc(NCc2ccncc2)c1-c1nnc(Nc2ccc(cc2)C(F)(F)F)o1
Show InChI InChI=1S/C19H16F3N7O/c1-29-11-25-16(24-10-12-6-8-23-9-7-12)15(29)17-27-28-18(30-17)26-14-4-2-13(3-5-14)19(20,21)22/h2-9,11,24H,10H2,1H3,(H,26,28)
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n/an/a 73n/an/an/an/an/an/a



Chemical Diversity, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 by enzymatic assay


Bioorg Med Chem Lett 16: 1440-4 (2006)


Article DOI: 10.1016/j.bmcl.2005.11.033
BindingDB Entry DOI: 10.7270/Q2NP240T
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50211981
PNG
(CHEMBL236420 | N-(4-isopropylphenyl)-1-(2-(pyridin...)
Show SMILES CC(C)c1ccc(NC(=O)c2ccnn2CCc2ccncc2)cc1
Show InChI InChI=1S/C20H22N4O/c1-15(2)17-3-5-18(6-4-17)23-20(25)19-9-13-22-24(19)14-10-16-7-11-21-12-8-16/h3-9,11-13,15H,10,14H2,1-2H3,(H,23,25)
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n/an/a 74n/an/an/an/an/an/a



Chemical Diversity, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 assessed as inhibition of phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 17: 3550-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.042
BindingDB Entry DOI: 10.7270/Q2MG7P6N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50201400
PNG
(CHEMBL238522 | N-(4-isopropylphenyl)-1-methyl-4-(p...)
Show SMILES CC(C)c1ccc(NC(=O)c2c(NCc3ccncc3)ncn2C)cc1
Show InChI InChI=1S/C20H23N5O/c1-14(2)16-4-6-17(7-5-16)24-20(26)18-19(23-13-25(18)3)22-12-15-8-10-21-11-9-15/h4-11,13-14,22H,12H2,1-3H3,(H,24,26)
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n/an/a 75n/an/an/an/an/an/a



Chemical Diversity, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 by cell-based assay


Bioorg Med Chem Lett 17: 1369-75 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.087
BindingDB Entry DOI: 10.7270/Q2125S92
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50211976
PNG
(CHEMBL397323 | N-(4-chlorophenyl)-1-(2-(pyridin-4-...)
Show SMILES Clc1ccc(NC(=O)c2ccnn2CCc2ccncc2)cc1
Show InChI InChI=1S/C17H15ClN4O/c18-14-1-3-15(4-2-14)21-17(23)16-7-11-20-22(16)12-8-13-5-9-19-10-6-13/h1-7,9-11H,8,12H2,(H,21,23)
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n/an/a 77n/an/an/an/an/an/a



Chemical Diversity, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 assessed as inhibition of phosphorylation in presence of 2 uM ATP by HTRF assay


Bioorg Med Chem Lett 17: 3550-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.042
BindingDB Entry DOI: 10.7270/Q2MG7P6N
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50201371
PNG
(CHEMBL241265 | N-(3-chloro-4-(trifluoromethyl)phen...)
Show SMILES Cn1ncc(NCc2ccncc2)c1C(=O)Nc1ccc(c(Cl)c1)C(F)(F)F
Show InChI InChI=1S/C18H15ClF3N5O/c1-27-16(15(10-25-27)24-9-11-4-6-23-7-5-11)17(28)26-12-2-3-13(14(19)8-12)18(20,21)22/h2-8,10,24H,9H2,1H3,(H,26,28)
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n/an/a 79n/an/an/an/an/an/a



Chemical Diversity, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 by cell-based assay


Bioorg Med Chem Lett 17: 1369-75 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.087
BindingDB Entry DOI: 10.7270/Q2125S92
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50201358
PNG
(CHEMBL391127 | N-(3,4-dichlorophenyl)-1-methyl-4-(...)
Show SMILES Cn1ncc(NCc2ccncc2)c1C(=O)Nc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C17H15Cl2N5O/c1-24-16(17(25)23-12-2-3-13(18)14(19)8-12)15(10-22-24)21-9-11-4-6-20-7-5-11/h2-8,10,21H,9H2,1H3,(H,23,25)
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n/an/a 82n/an/an/an/an/an/a



Chemical Diversity, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 by cell-based assay


Bioorg Med Chem Lett 17: 1369-75 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.087
BindingDB Entry DOI: 10.7270/Q2125S92
More data for this
Ligand-Target Pair
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