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Compile Data Set for Download or QSAR

Found 160 hits from Chimerix, Inc.   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
HIV RT (65R/184V)


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM77092
PNG
(CMX-157 | CMX157 | HDP-tenofovir | Tenofovir Exali...)
Show SMILES CCCCCCCCCCCCCCCCOCCCOP(O)(=O)CO[C@H](C)Cn1cnc2c(N)ncnc12
Show InChI InChI=1/C28H52N5O5P/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-18-36-19-17-20-38-39(34,35)24-37-25(2)21-33-23-32-26-27(29)30-22-31-28(26)33/h22-23,25H,3-21,24H2,1-2H3,(H,34,35)(H2,29,30,31)/t25-/s2
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n/an/a 1.80n/an/an/an/an/an/a



Chimerix, Inc.

US Patent


Assay Description
The PhenoSense report form includes drug resistance information for all of the approved nucleoside reverse transcriptase inhibitors (NRTIs), nonnucle...


US Patent US9694024 (2017)


BindingDB Entry DOI: 10.7270/Q2BV7DRT
More data for this
Ligand-Target Pair
HIV RT (41L/67N/210W/215Y/184V)


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM77092
PNG
(CMX-157 | CMX157 | HDP-tenofovir | Tenofovir Exali...)
Show SMILES CCCCCCCCCCCCCCCCOCCCOP(O)(=O)CO[C@H](C)Cn1cnc2c(N)ncnc12
Show InChI InChI=1/C28H52N5O5P/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-18-36-19-17-20-38-39(34,35)24-37-25(2)21-33-23-32-26-27(29)30-22-31-28(26)33/h22-23,25H,3-21,24H2,1-2H3,(H,34,35)(H2,29,30,31)/t25-/s2
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n/an/a 3.10n/an/an/an/an/an/a



Chimerix, Inc.

US Patent


Assay Description
The PhenoSense report form includes drug resistance information for all of the approved nucleoside reverse transcriptase inhibitors (NRTIs), nonnucle...


US Patent US9694024 (2017)


BindingDB Entry DOI: 10.7270/Q2BV7DRT
More data for this
Ligand-Target Pair
HIV RT (41L/67N/70R/215F/219E)


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM77092
PNG
(CMX-157 | CMX157 | HDP-tenofovir | Tenofovir Exali...)
Show SMILES CCCCCCCCCCCCCCCCOCCCOP(O)(=O)CO[C@H](C)Cn1cnc2c(N)ncnc12
Show InChI InChI=1/C28H52N5O5P/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-18-36-19-17-20-38-39(34,35)24-37-25(2)21-33-23-32-26-27(29)30-22-31-28(26)33/h22-23,25H,3-21,24H2,1-2H3,(H,34,35)(H2,29,30,31)/t25-/s2
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n/an/a 3.80n/an/an/an/an/an/a



Chimerix, Inc.

US Patent


Assay Description
The PhenoSense report form includes drug resistance information for all of the approved nucleoside reverse transcriptase inhibitors (NRTIs), nonnucle...


US Patent US9694024 (2017)


BindingDB Entry DOI: 10.7270/Q2BV7DRT
More data for this
Ligand-Target Pair
HIV RT (75I/77L/116Y/151M/184V)


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM77092
PNG
(CMX-157 | CMX157 | HDP-tenofovir | Tenofovir Exali...)
Show SMILES CCCCCCCCCCCCCCCCOCCCOP(O)(=O)CO[C@H](C)Cn1cnc2c(N)ncnc12
Show InChI InChI=1/C28H52N5O5P/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-18-36-19-17-20-38-39(34,35)24-37-25(2)21-33-23-32-26-27(29)30-22-31-28(26)33/h22-23,25H,3-21,24H2,1-2H3,(H,34,35)(H2,29,30,31)/t25-/s2
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n/an/a 5n/an/an/an/an/an/a



Chimerix, Inc.

US Patent


Assay Description
The PhenoSense report form includes drug resistance information for all of the approved nucleoside reverse transcriptase inhibitors (NRTIs), nonnucle...


US Patent US9694024 (2017)


BindingDB Entry DOI: 10.7270/Q2BV7DRT
More data for this
Ligand-Target Pair
HIV RT (41L/210W/215Y/184V/69SSS)


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM77092
PNG
(CMX-157 | CMX157 | HDP-tenofovir | Tenofovir Exali...)
Show SMILES CCCCCCCCCCCCCCCCOCCCOP(O)(=O)CO[C@H](C)Cn1cnc2c(N)ncnc12
Show InChI InChI=1/C28H52N5O5P/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-18-36-19-17-20-38-39(34,35)24-37-25(2)21-33-23-32-26-27(29)30-22-31-28(26)33/h22-23,25H,3-21,24H2,1-2H3,(H,34,35)(H2,29,30,31)/t25-/s2
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n/an/a 9n/an/an/an/an/an/a



Chimerix, Inc.

US Patent


Assay Description
The PhenoSense report form includes drug resistance information for all of the approved nucleoside reverse transcriptase inhibitors (NRTIs), nonnucle...


US Patent US9694024 (2017)


BindingDB Entry DOI: 10.7270/Q2BV7DRT
More data for this
Ligand-Target Pair
HIV RT (41L/67N/210W/215Y/184V)


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM77092
PNG
(CMX-157 | CMX157 | HDP-tenofovir | Tenofovir Exali...)
Show SMILES CCCCCCCCCCCCCCCCOCCCOP(O)(=O)CO[C@H](C)Cn1cnc2c(N)ncnc12
Show InChI InChI=1/C28H52N5O5P/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-18-36-19-17-20-38-39(34,35)24-37-25(2)21-33-23-32-26-27(29)30-22-31-28(26)33/h22-23,25H,3-21,24H2,1-2H3,(H,34,35)(H2,29,30,31)/t25-/s2
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n/an/a 19n/an/an/an/an/an/a



Chimerix, Inc.

US Patent


Assay Description
The PhenoSense report form includes drug resistance information for all of the approved nucleoside reverse transcriptase inhibitors (NRTIs), nonnucle...


US Patent US9694024 (2017)


BindingDB Entry DOI: 10.7270/Q2BV7DRT
More data for this
Ligand-Target Pair
HIV RT (65R/184V)


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM77145
PNG
(9-((R)-2-((Bis(((isopropoxycarbonyl)oxy)methoxy)ph...)
Show SMILES CC(C)OC(=O)OCOP(=O)(CO[C@H](C)Cn1cnc2c(N)ncnc12)OCOC(=O)OC(C)C
Show InChI InChI=1S/C19H30N5O10P/c1-12(2)33-18(25)28-9-31-35(27,32-10-29-19(26)34-13(3)4)11-30-14(5)6-24-8-23-15-16(20)21-7-22-17(15)24/h7-8,12-14H,6,9-11H2,1-5H3,(H2,20,21,22)/t14-/m1/s1
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n/an/a 1.04E+3n/an/an/an/an/an/a



Chimerix, Inc.

US Patent


Assay Description
The PhenoSense report form includes drug resistance information for all of the approved nucleoside reverse transcriptase inhibitors (NRTIs), nonnucle...


US Patent US9694024 (2017)


BindingDB Entry DOI: 10.7270/Q2BV7DRT
More data for this
Ligand-Target Pair
HIV RT (41L/67N/210W/215Y/184V)


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM77145
PNG
(9-((R)-2-((Bis(((isopropoxycarbonyl)oxy)methoxy)ph...)
Show SMILES CC(C)OC(=O)OCOP(=O)(CO[C@H](C)Cn1cnc2c(N)ncnc12)OCOC(=O)OC(C)C
Show InChI InChI=1S/C19H30N5O10P/c1-12(2)33-18(25)28-9-31-35(27,32-10-29-19(26)34-13(3)4)11-30-14(5)6-24-8-23-15-16(20)21-7-22-17(15)24/h7-8,12-14H,6,9-11H2,1-5H3,(H2,20,21,22)/t14-/m1/s1
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n/an/a 5.39E+3n/an/an/an/an/an/a



Chimerix, Inc.

US Patent


Assay Description
The PhenoSense report form includes drug resistance information for all of the approved nucleoside reverse transcriptase inhibitors (NRTIs), nonnucle...


US Patent US9694024 (2017)


BindingDB Entry DOI: 10.7270/Q2BV7DRT
More data for this
Ligand-Target Pair
HIV RT (41L/210W/215Y/184V/69SSS)


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM77145
PNG
(9-((R)-2-((Bis(((isopropoxycarbonyl)oxy)methoxy)ph...)
Show SMILES CC(C)OC(=O)OCOP(=O)(CO[C@H](C)Cn1cnc2c(N)ncnc12)OCOC(=O)OC(C)C
Show InChI InChI=1S/C19H30N5O10P/c1-12(2)33-18(25)28-9-31-35(27,32-10-29-19(26)34-13(3)4)11-30-14(5)6-24-8-23-15-16(20)21-7-22-17(15)24/h7-8,12-14H,6,9-11H2,1-5H3,(H2,20,21,22)/t14-/m1/s1
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n/an/a>6.47E+3n/an/an/an/an/an/a



Chimerix, Inc.

US Patent


Assay Description
The PhenoSense report form includes drug resistance information for all of the approved nucleoside reverse transcriptase inhibitors (NRTIs), nonnucle...


US Patent US9694024 (2017)


BindingDB Entry DOI: 10.7270/Q2BV7DRT
More data for this
Ligand-Target Pair
HIV RT (75I/77L/116Y/151M/184V)


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM77145
PNG
(9-((R)-2-((Bis(((isopropoxycarbonyl)oxy)methoxy)ph...)
Show SMILES CC(C)OC(=O)OCOP(=O)(CO[C@H](C)Cn1cnc2c(N)ncnc12)OCOC(=O)OC(C)C
Show InChI InChI=1S/C19H30N5O10P/c1-12(2)33-18(25)28-9-31-35(27,32-10-29-19(26)34-13(3)4)11-30-14(5)6-24-8-23-15-16(20)21-7-22-17(15)24/h7-8,12-14H,6,9-11H2,1-5H3,(H2,20,21,22)/t14-/m1/s1
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n/an/a>6.49E+3n/an/an/an/an/an/a



Chimerix, Inc.

US Patent


Assay Description
The PhenoSense report form includes drug resistance information for all of the approved nucleoside reverse transcriptase inhibitors (NRTIs), nonnucle...


US Patent US9694024 (2017)


BindingDB Entry DOI: 10.7270/Q2BV7DRT
More data for this
Ligand-Target Pair
HIV RT (41L/67N/70R/215F/219E)


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM77145
PNG
(9-((R)-2-((Bis(((isopropoxycarbonyl)oxy)methoxy)ph...)
Show SMILES CC(C)OC(=O)OCOP(=O)(CO[C@H](C)Cn1cnc2c(N)ncnc12)OCOC(=O)OC(C)C
Show InChI InChI=1S/C19H30N5O10P/c1-12(2)33-18(25)28-9-31-35(27,32-10-29-19(26)34-13(3)4)11-30-14(5)6-24-8-23-15-16(20)21-7-22-17(15)24/h7-8,12-14H,6,9-11H2,1-5H3,(H2,20,21,22)/t14-/m1/s1
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n/an/a 6.52E+3n/an/an/an/an/an/a



Chimerix, Inc.

US Patent


Assay Description
The PhenoSense report form includes drug resistance information for all of the approved nucleoside reverse transcriptase inhibitors (NRTIs), nonnucle...


US Patent US9694024 (2017)


BindingDB Entry DOI: 10.7270/Q2BV7DRT
More data for this
Ligand-Target Pair
HIV RT (41L/67N/210W/215Y/184V)


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM77145
PNG
(9-((R)-2-((Bis(((isopropoxycarbonyl)oxy)methoxy)ph...)
Show SMILES CC(C)OC(=O)OCOP(=O)(CO[C@H](C)Cn1cnc2c(N)ncnc12)OCOC(=O)OC(C)C
Show InChI InChI=1S/C19H30N5O10P/c1-12(2)33-18(25)28-9-31-35(27,32-10-29-19(26)34-13(3)4)11-30-14(5)6-24-8-23-15-16(20)21-7-22-17(15)24/h7-8,12-14H,6,9-11H2,1-5H3,(H2,20,21,22)/t14-/m1/s1
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n/an/a>8.51E+3n/an/an/an/an/an/a



Chimerix, Inc.

US Patent


Assay Description
The PhenoSense report form includes drug resistance information for all of the approved nucleoside reverse transcriptase inhibitors (NRTIs), nonnucle...


US Patent US9694024 (2017)


BindingDB Entry DOI: 10.7270/Q2BV7DRT
More data for this
Ligand-Target Pair
HIV-1 B HXB2-LAI-IIIB-BRU


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM50002692
PNG
((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)
Show SMILES Cc1cn([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)c(=O)[nH]c1=O
Show InChI InChI=1/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3,6-8,16H,2,4H2,1H3,(H,12,17,18)/t6-,7+,8+/s2
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n/an/an/an/a 3n/an/an/an/a



Chimerix, Inc.

US Patent


Assay Description
The in vitro antiviral activity profile for CMX157 was evaluated for cell-type effects and HIV strain effects. It is active against all major subtype...


US Patent US9694024 (2017)


BindingDB Entry DOI: 10.7270/Q2BV7DRT
More data for this
Ligand-Target Pair
HIV-1 B HXB2-LAI-IIIB-BRU


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM77141
PNG
(CMX157 ion)
Show SMILES CCCCCCCCCCCCCCCCOCCCOP([O-])(=O)CO[C@H](C)Cn1cnc2c(N)ncnc12
Show InChI InChI=1/C28H52N5O5P/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-18-36-19-17-20-38-39(34,35)24-37-25(2)21-33-23-32-26-27(29)30-22-31-28(26)33/h22-23,25H,3-21,24H2,1-2H3,(H,34,35)(H2,29,30,31)/p-1/t25-/s2
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n/an/an/an/a<30n/an/an/an/a



Chimerix, Inc.

US Patent


Assay Description
The in vitro antiviral activity profile for CMX157 was evaluated for cell-type effects and HIV strain effects. It is active against all major subtype...


US Patent US9694024 (2017)


BindingDB Entry DOI: 10.7270/Q2BV7DRT
More data for this
Ligand-Target Pair
HIV-1 B HXB2-LAI-IIIB-BRU


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM77097
PNG
(CMX157-210)
Show SMILES C[C@H](Cn1cnc2c(N)ncnc12)OCP(O)(=O)OCCCO
Show InChI InChI=1/C12H20N5O5P/c1-9(21-8-23(19,20)22-4-2-3-18)5-17-7-16-10-11(13)14-6-15-12(10)17/h6-7,9,18H,2-5,8H2,1H3,(H,19,20)(H2,13,14,15)/t9-/s2
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n/an/an/an/a>1.00E+4n/an/an/an/a



Chimerix, Inc.

US Patent


Assay Description
The in vitro antiviral activity profile for CMX157 was evaluated for cell-type effects and HIV strain effects. It is active against all major subtype...


US Patent US9694024 (2017)


BindingDB Entry DOI: 10.7270/Q2BV7DRT
More data for this
Ligand-Target Pair
HIV-1 B HXB2-LAI-IIIB-BRU


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM77105
PNG
(CMX157-211)
Show SMILES C[C@H](Cn1cnc2c(N)ncnc12)OCP(O)(=O)OCCCOCC(O)=O
Show InChI InChI=1/C14H22N5O7P/c1-10(5-19-8-18-12-13(15)16-7-17-14(12)19)25-9-27(22,23)26-4-2-3-24-6-11(20)21/h7-8,10H,2-6,9H2,1H3,(H,20,21)(H,22,23)(H2,15,16,17)/t10-/s2
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n/an/an/an/a>1.00E+4n/an/an/an/a



Chimerix, Inc.

US Patent


Assay Description
The in vitro antiviral activity profile for CMX157 was evaluated for cell-type effects and HIV strain effects. It is active against all major subtype...


US Patent US9694024 (2017)


BindingDB Entry DOI: 10.7270/Q2BV7DRT
More data for this
Ligand-Target Pair
HIV-1 B HXB2-LAI-IIIB-BRU


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM77108
PNG
(CMX157-220)
Show SMILES C[C@H](Cn1cnc2c(N)ncnc12)OCP(O)(=O)OCCCOCCCC(O)=O
Show InChI InChI=1/C16H26N5O7P/c1-12(8-21-10-20-14-15(17)18-9-19-16(14)21)27-11-29(24,25)28-7-3-6-26-5-2-4-13(22)23/h9-10,12H,2-8,11H2,1H3,(H,22,23)(H,24,25)(H2,17,18,19)/t12-/s2
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n/an/an/an/a>1.00E+4n/an/an/an/a



Chimerix, Inc.

US Patent


Assay Description
The in vitro antiviral activity profile for CMX157 was evaluated for cell-type effects and HIV strain effects. It is active against all major subtype...


US Patent US9694024 (2017)


BindingDB Entry DOI: 10.7270/Q2BV7DRT
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263072
PNG
(US9708359, 1 | US9708359, 122 | US9708359, 38 | US...)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1)C(N)=O
Show InChI InChI=1/C13H17N5O5/c1-4-16-10(14)7-5(11(15)22)2-18(12(7)17-4)13-9(21)8(20)6(3-19)23-13/h2,6,8-9,13,19-21H,3H2,1H3,(H2,15,22)(H2,14,16,17)/t6-,8-,9-,13-/s2
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n/an/an/an/a 2.65E+3n/an/an/an/a



Chimerix, Inc.

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
BindingDB Entry DOI: 10.7270/Q22F7QGB
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263073
PNG
(US9708359, 2)
Show SMILES CC(C)[C@H](N)C(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12
Show InChI InChI=1/C18H26N6O6/c1-6(2)11(19)18(28)29-5-9-12(25)13(26)17(30-9)24-4-8(15(21)27)10-14(20)22-7(3)23-16(10)24/h4,6,9,11-13,17,25-26H,5,19H2,1-3H3,(H2,21,27)(H2,20,22,23)/t9-,11+,12-,13-,17-/s2
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n/an/an/an/a 3.03E+3n/an/an/an/a



Chimerix, Inc.

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
BindingDB Entry DOI: 10.7270/Q22F7QGB
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263074
PNG
(US9708359, 3)
Show SMILES C[C@H](N)C(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12
Show InChI InChI=1/C16H22N6O6/c1-5(17)16(26)27-4-8-10(23)11(24)15(28-8)22-3-7(13(19)25)9-12(18)20-6(2)21-14(9)22/h3,5,8,10-11,15,23-24H,4,17H2,1-2H3,(H2,19,25)(H2,18,20,21)/t5-,8+,10+,11+,15+/s2
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n/an/an/an/a 2.00E+3n/an/an/an/a



Chimerix, Inc.

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
BindingDB Entry DOI: 10.7270/Q22F7QGB
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263075
PNG
(US9708359, 4)
Show SMILES CCCCCCCCCCCCCCCCOCCC(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12
Show InChI InChI=1/C32H53N5O7/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-18-42-19-17-25(38)43-21-24-27(39)28(40)32(44-24)37-20-23(30(34)41)26-29(33)35-22(2)36-31(26)37/h20,24,27-28,32,39-40H,3-19,21H2,1-2H3,(H2,34,41)(H2,33,35,36)/t24-,27-,28-,32-/s2
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n/an/an/an/a 3.50E+3n/an/an/an/a



Chimerix, Inc.

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
BindingDB Entry DOI: 10.7270/Q22F7QGB
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263076
PNG
(US9708359, 5)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](COC(=O)[C@@H](N)Cc4ccccc4)[C@@H](O)[C@H]3O)c2n1)C(N)=O
Show InChI InChI=1/C22H26N6O6/c1-10-26-18(24)15-12(19(25)31)8-28(20(15)27-10)21-17(30)16(29)14(34-21)9-33-22(32)13(23)7-11-5-3-2-4-6-11/h2-6,8,13-14,16-17,21,29-30H,7,9,23H2,1H3,(H2,25,31)(H2,24,26,27)/t13-,14+,16+,17+,21+/s2
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n/an/an/an/a 2.20E+3n/an/an/an/a



Chimerix, Inc.

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
BindingDB Entry DOI: 10.7270/Q22F7QGB
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263072
PNG
(US9708359, 1 | US9708359, 122 | US9708359, 38 | US...)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1)C(N)=O
Show InChI InChI=1/C13H17N5O5/c1-4-16-10(14)7-5(11(15)22)2-18(12(7)17-4)13-9(21)8(20)6(3-19)23-13/h2,6,8-9,13,19-21H,3H2,1H3,(H2,15,22)(H2,14,16,17)/t6-,8-,9-,13-/s2
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n/an/an/an/a 3.08E+3n/an/an/an/a



Chimerix, Inc.

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
BindingDB Entry DOI: 10.7270/Q22F7QGB
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263078
PNG
(US9708359, 71)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)c2n1)C(N)=O
Show InChI InChI=1/C13H18N5O8P/c1-4-16-10(14)7-5(11(15)21)2-18(12(7)17-4)13-9(20)8(19)6(26-13)3-25-27(22,23)24/h2,6,8-9,13,19-20H,3H2,1H3,(H2,15,21)(H2,14,16,17)(H2,22,23,24)/t6-,8-,9-,13-/s2
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n/an/an/an/a 3.15E+3n/an/an/an/a



Chimerix, Inc.

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
BindingDB Entry DOI: 10.7270/Q22F7QGB
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263079
PNG
(US9708359, 77)
Show SMILES CC(C)C[C@H](N)C(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12
Show InChI InChI=1/C19H28N6O6/c1-7(2)4-10(20)19(29)30-6-11-13(26)14(27)18(31-11)25-5-9(16(22)28)12-15(21)23-8(3)24-17(12)25/h5,7,10-11,13-14,18,26-27H,4,6,20H2,1-3H3,(H2,22,28)(H2,21,23,24)/t10-,11+,13+,14+,18+/s2
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n/an/an/an/a 4.40E+3n/an/an/an/a



Chimerix, Inc.

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
BindingDB Entry DOI: 10.7270/Q22F7QGB
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263080
PNG
(US9708359, 76)
Show SMILES CC(C)C[C@H](NC(=O)OCC1c2ccccc2-c2ccccc12)C(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12
Show InChI InChI=1/C34H38N6O8/c1-16(2)12-24(39-34(45)47-14-23-20-10-6-4-8-18(20)19-9-5-7-11-21(19)23)33(44)46-15-25-27(41)28(42)32(48-25)40-13-22(30(36)43)26-29(35)37-17(3)38-31(26)40/h4-11,13,16,23-25,27-28,32,41-42H,12,14-15H2,1-3H3,(H2,36,43)(H,39,45)(H2,35,37,38)/t24-,25+,27+,28+,32+/s2
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n/an/an/an/a 1.64E+4n/an/an/an/a



Chimerix, Inc.

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
BindingDB Entry DOI: 10.7270/Q22F7QGB
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263081
PNG
(US9708359, 107)
Show SMILES C[C@H](NP(=O)(OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12)Oc1ccccc1)C(=O)OCc1ccccc1
Show InChI InChI=1/C29H33N6O9P/c1-16(29(39)41-14-18-9-5-3-6-10-18)34-45(40,44-19-11-7-4-8-12-19)42-15-21-23(36)24(37)28(43-21)35-13-20(26(31)38)22-25(30)32-17(2)33-27(22)35/h3-13,16,21,23-24,28,36-37H,14-15H2,1-2H3,(H2,31,38)(H,34,40)(H2,30,32,33)/t16-,21+,23+,24+,28+,45?/s2
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n/an/an/an/a 1.81E+4n/an/an/an/a



Chimerix, Inc.

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
BindingDB Entry DOI: 10.7270/Q22F7QGB
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263082
PNG
(US9708359, 111)
Show SMILES COC(=O)[C@H](C)NP(=O)(OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12)Oc1ccccc1
Show InChI InChI=1/C23H29N6O9P/c1-11(23(33)35-3)28-39(34,38-13-7-5-4-6-8-13)36-10-15-17(30)18(31)22(37-15)29-9-14(20(25)32)16-19(24)26-12(2)27-21(16)29/h4-9,11,15,17-18,22,30-31H,10H2,1-3H3,(H2,25,32)(H,28,34)(H2,24,26,27)/t11-,15+,17+,18+,22+,39?/s2
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n/an/an/an/a 2.10E+4n/an/an/an/a



Chimerix, Inc.

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
BindingDB Entry DOI: 10.7270/Q22F7QGB
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263083
PNG
(US9708359, 126)
Show SMILES C[C@@H](NP(=O)(N[C@@H](C)C(=O)OCc1ccccc1)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12)C(=O)OCc1ccccc1
Show InChI InChI=1/C33H40N7O10P/c1-18(32(44)47-15-21-10-6-4-7-11-21)38-51(46,39-19(2)33(45)48-16-22-12-8-5-9-13-22)49-17-24-26(41)27(42)31(50-24)40-14-23(29(35)43)25-28(34)36-20(3)37-30(25)40/h4-14,18-19,24,26-27,31,41-42H,15-17H2,1-3H3,(H2,35,43)(H2,34,36,37)(H2,38,39,46)/t18-,19+,24-,26-,27-,31-,51?/s2
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n/an/an/an/a 3.36E+4n/an/an/an/a



Chimerix, Inc.

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
BindingDB Entry DOI: 10.7270/Q22F7QGB
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263083
PNG
(US9708359, 126)
Show SMILES C[C@@H](NP(=O)(N[C@@H](C)C(=O)OCc1ccccc1)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12)C(=O)OCc1ccccc1
Show InChI InChI=1/C33H40N7O10P/c1-18(32(44)47-15-21-10-6-4-7-11-21)38-51(46,39-19(2)33(45)48-16-22-12-8-5-9-13-22)49-17-24-26(41)27(42)31(50-24)40-14-23(29(35)43)25-28(34)36-20(3)37-30(25)40/h4-14,18-19,24,26-27,31,41-42H,15-17H2,1-3H3,(H2,35,43)(H2,34,36,37)(H2,38,39,46)/t18-,19+,24-,26-,27-,31-,51?/s2
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n/an/an/an/a 3.89E+4n/an/an/an/a



Chimerix, Inc.

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
BindingDB Entry DOI: 10.7270/Q22F7QGB
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263084
PNG
(US9708359, 133)
Show SMILES CC(C)OC(=O)[C@H](C)NP(=O)(OC[C@H]1O[C@H]([C@H](OC(=O)C(C)C)[C@@H]1OC(=O)C(C)C)n1cc(C(N)=O)c2c(N)nc(C)nc12)Oc1ccccc1
Show InChI InChI=1/C33H45N6O11P/c1-16(2)31(41)48-25-23(15-45-51(44,50-21-12-10-9-11-13-21)38-19(7)33(43)46-18(5)6)47-30(26(25)49-32(42)17(3)4)39-14-22(28(35)40)24-27(34)36-20(8)37-29(24)39/h9-14,16-19,23,25-26,30H,15H2,1-8H3,(H2,35,40)(H,38,44)(H2,34,36,37)/t19-,23+,25+,26+,30+,51?/s2
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n/an/an/an/a 2.57E+4n/an/an/an/a



Chimerix, Inc.

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
BindingDB Entry DOI: 10.7270/Q22F7QGB
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263085
PNG
(US9708359, 137)
Show SMILES CC(C)OC(=O)[C@H](C)NP(=O)(OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12)OCc1ccccc1C
Show InChI InChI=1/C27H37N6O9P/c1-13(2)41-27(37)15(4)32-43(38,39-11-17-9-7-6-8-14(17)3)40-12-19-21(34)22(35)26(42-19)33-10-18(24(29)36)20-23(28)30-16(5)31-25(20)33/h6-10,13,15,19,21-22,26,34-35H,11-12H2,1-5H3,(H2,29,36)(H,32,38)(H2,28,30,31)/t15-,19+,21+,22+,26+,43?/s2
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n/an/an/an/a 2.00E+4n/an/an/an/a



Chimerix, Inc.

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
BindingDB Entry DOI: 10.7270/Q22F7QGB
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263086
PNG
(US9708359, 139)
Show SMILES CCCCCCCCCCCCCCCCOCCCOC(=O)[C@H](C)NP(=O)(OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12)Oc1ccccc1
Show InChI InChI=1/C41H65N6O10P/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-20-24-53-25-21-26-54-41(51)29(2)46-58(52,57-31-22-18-17-19-23-31)55-28-33-35(48)36(49)40(56-33)47-27-32(38(43)50)34-37(42)44-30(3)45-39(34)47/h17-19,22-23,27,29,33,35-36,40,48-49H,4-16,20-21,24-26,28H2,1-3H3,(H2,43,50)(H,46,52)(H2,42,44,45)/t29-,33+,35+,36+,40+,58?/s2
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n/an/an/an/a 2.30E+3n/an/an/an/a



Chimerix, Inc.

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
BindingDB Entry DOI: 10.7270/Q22F7QGB
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263087
PNG
(US9708359, 141)
Show SMILES CC(C)OC(=O)[C@H](C)NP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12
Show InChI InChI=1/C19H29N6O9P/c1-7(2)33-19(29)8(3)24-35(30,31)32-6-11-13(26)14(27)18(34-11)25-5-10(16(21)28)12-15(20)22-9(4)23-17(12)25/h5,7-8,11,13-14,18,26-27H,6H2,1-4H3,(H2,21,28)(H2,20,22,23)(H2,24,30,31)/t8-,11+,13+,14+,18+/s2
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n/an/an/an/a 3.20E+3n/an/an/an/a



Chimerix, Inc.

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
BindingDB Entry DOI: 10.7270/Q22F7QGB
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263088
PNG
(US9708359, 143)
Show SMILES CCCCCCCCCCCCCCCCOCCCOC(=O)[C@H](C)NP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12
Show InChI InChI=1/C35H61N6O10P/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-19-48-20-18-21-49-35(45)24(2)40-52(46,47)50-23-27-29(42)30(43)34(51-27)41-22-26(32(37)44)28-31(36)38-25(3)39-33(28)41/h22,24,27,29-30,34,42-43H,4-21,23H2,1-3H3,(H2,37,44)(H2,36,38,39)(H2,40,46,47)/t24-,27+,29+,30+,34+/s2
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n/an/an/an/a 2.63E+4n/an/an/an/a



Chimerix, Inc.

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
BindingDB Entry DOI: 10.7270/Q22F7QGB
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263089
PNG
(US9708359, 145)
Show SMILES CCCCCCCCC(=O)Oc1ccc(COP(=O)(OCc2ccc(OC(=O)CCCCCCCC)cc2)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2cc(C(N)=O)c3c(N)nc(C)nc23)cc1
Show InChI InChI=1/C45H63N5O15P2/c1-4-6-8-10-12-14-16-37(51)62-33-22-18-31(19-23-33)27-60-67(58,61-28-32-20-24-34(25-21-32)63-38(52)17-15-13-11-9-7-5-2)65-66(56,57)59-29-36-40(53)41(54)45(64-36)50-26-35(43(47)55)39-42(46)48-30(3)49-44(39)50/h18-26,36,40-41,45,53-54H,4-17,27-29H2,1-3H3,(H2,47,55)(H,56,57)(H2,46,48,49)/t36-,40-,41-,45-/s2
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n/an/an/an/a 7.40E+3n/an/an/an/a



Chimerix, Inc.

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
BindingDB Entry DOI: 10.7270/Q22F7QGB
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263090
PNG
(US9708359, 7)
Show SMILES Cc1nc(O)c2c(cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1)C(N)=O
Show InChI InChI=1/C13H16N4O6/c1-4-15-11-7(12(22)16-4)5(10(14)21)2-17(11)13-9(20)8(19)6(3-18)23-13/h2,6,8-9,13,18-20H,3H2,1H3,(H2,14,21)(H,15,16,22)/t6-,8-,9-,13-/s2
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n/an/an/an/a 5.38E+4n/an/an/an/a



Chimerix, Inc.

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
BindingDB Entry DOI: 10.7270/Q22F7QGB
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263091
PNG
(US9708359, 8)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2[n+]1[O-])C(N)=O
Show InChI InChI=1/C13H17N5O6/c1-4-16-10(14)7-5(11(15)22)2-17(12(7)18(4)23)13-9(21)8(20)6(3-19)24-13/h2,6,8-9,13,19-21H,3H2,1H3,(H2,14,16)(H2,15,22)/t6-,8-,9-,13-/s2
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n/an/an/an/a 2.36E+4n/an/an/an/a



Chimerix, Inc.

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
BindingDB Entry DOI: 10.7270/Q22F7QGB
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263092
PNG
(US9708359, 10)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1)-c1nn[nH]n1
Show InChI InChI=1/C13H16N8O4/c1-4-15-10(14)7-5(11-17-19-20-18-11)2-21(12(7)16-4)13-9(24)8(23)6(3-22)25-13/h2,6,8-9,13,22-24H,3H2,1H3,(H2,14,15,16)(H,17,18,19,20)/t6-,8-,9-,13-/s2
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n/an/an/an/a 6.15E+4n/an/an/an/a



Chimerix, Inc.

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
BindingDB Entry DOI: 10.7270/Q22F7QGB
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263093
PNG
(US9708359, 11)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1)C#N
Show InChI InChI=1/C13H15N5O4/c1-5-16-11(15)8-6(2-14)3-18(12(8)17-5)13-10(21)9(20)7(4-19)22-13/h3,7,9-10,13,19-21H,4H2,1H3,(H2,15,16,17)/t7-,9-,10-,13-/s2
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n/an/an/an/a>1.21E+5n/an/an/an/a



Chimerix, Inc.

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
BindingDB Entry DOI: 10.7270/Q22F7QGB
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263094
PNG
(US9708359, 14)
Show SMILES Cc1nc(N)c2c(I)cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1
Show InChI InChI=1/C12H15IN4O4/c1-4-15-10(14)7-5(13)2-17(11(7)16-4)12-9(20)8(19)6(3-18)21-12/h2,6,8-9,12,18-20H,3H2,1H3,(H2,14,15,16)/t6-,8-,9-,12-/s2
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
BindingDB Entry DOI: 10.7270/Q22F7QGB
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263095
PNG
(US9708359, 16 | US9708359, 28)
Show SMILES NC(=S)c1cn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c2nc(nc(N)c12)-c1ccccc1
Show InChI InChI=1/C18H19N5O4S/c19-14-11-9(15(20)28)6-23(18-13(26)12(25)10(7-24)27-18)17(11)22-16(21-14)8-4-2-1-3-5-8/h1-6,10,12-13,18,24-26H,7H2,(H2,20,28)(H2,19,21,22)/t10-,12-,13-,18-/s2
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
BindingDB Entry DOI: 10.7270/Q22F7QGB
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263096
PNG
(US9708359, 17)
Show SMILES Nc1nc(nc2n(cc(C#N)c12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O)-c1ccccc1
Show InChI InChI=1/C18H17N5O4/c19-6-10-7-23(18-14(26)13(25)11(8-24)27-18)17-12(10)15(20)21-16(22-17)9-4-2-1-3-5-9/h1-5,7,11,13-14,18,24-26H,8H2,(H2,20,21,22)/t11-,13-,14-,18-/s2
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
BindingDB Entry DOI: 10.7270/Q22F7QGB
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263097
PNG
(US9708359, 18)
Show SMILES NC(=O)c1cn([C@@H]2O[C@H](COCc3ccccc3)[C@@H](O)[C@H]2O)c2nc(nc(N)c12)-c1ccccc1
Show InChI InChI=1/C25H25N5O5/c26-21-18-16(22(27)33)11-30(24(18)29-23(28-21)15-9-5-2-6-10-15)25-20(32)19(31)17(35-25)13-34-12-14-7-3-1-4-8-14/h1-11,17,19-20,25,31-32H,12-13H2,(H2,27,33)(H2,26,28,29)/t17-,19-,20-,25-/s2
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
BindingDB Entry DOI: 10.7270/Q22F7QGB
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263098
PNG
(US9708359, 19)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](COCc4ccccc4)[C@@H](O)[C@H]3O)c2n1)C(N)=O
Show InChI InChI=1/C20H23N5O5/c1-10-23-17(21)14-12(18(22)28)7-25(19(14)24-10)20-16(27)15(26)13(30-20)9-29-8-11-5-3-2-4-6-11/h2-7,13,15-16,20,26-27H,8-9H2,1H3,(H2,22,28)(H2,21,23,24)/t13-,15-,16-,20-/s2
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
BindingDB Entry DOI: 10.7270/Q22F7QGB
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263099
PNG
(US9708359, 20)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](CO)[C@H]4OC(C)(C)O[C@@H]34)c2n1)C(N)=O
Show InChI InChI=1/C16H21N5O5/c1-6-19-12(17)9-7(13(18)23)4-21(14(9)20-6)15-11-10(8(5-22)24-15)25-16(2,3)26-11/h4,8,10-11,15,22H,5H2,1-3H3,(H2,18,23)(H2,17,19,20)/t8-,10-,11-,15-/s2
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n/an/an/an/a>2.00E+4n/an/an/an/a



Chimerix, Inc.

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
BindingDB Entry DOI: 10.7270/Q22F7QGB
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263100
PNG
(US9708359, 21)
Show SMILES CCOP(=O)(COC[C@H]1O[C@H]([C@@H]2OC(C)(C)O[C@H]12)n1cc(C(N)=O)c2c(N)nc(C)nc12)OCC
Show InChI InChI=1/C21H32N5O8P/c1-6-30-35(28,31-7-2)10-29-9-13-15-16(34-21(4,5)33-15)20(32-13)26-8-12(18(23)27)14-17(22)24-11(3)25-19(14)26/h8,13,15-16,20H,6-7,9-10H2,1-5H3,(H2,23,27)(H2,22,24,25)/t13-,15-,16-,20-/s2
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
BindingDB Entry DOI: 10.7270/Q22F7QGB
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263101
PNG
(US9708359, 22)
Show SMILES CCCCCCCCCCCCCCCOCCCOP(O)(=O)COC[C@H]1O[C@H]([C@@H]2OC(C)(C)O[C@H]12)n1cc(C(N)=O)c2c(N)nc(C)nc12
Show InChI InChI=1/C35H60N5O9P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-19-44-20-18-21-46-50(42,43)24-45-23-27-29-30(49-35(3,4)48-29)34(47-27)40-22-26(32(37)41)28-31(36)38-25(2)39-33(28)40/h22,27,29-30,34H,5-21,23-24H2,1-4H3,(H2,37,41)(H,42,43)(H2,36,38,39)/t27-,29-,30-,34-/s2
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
BindingDB Entry DOI: 10.7270/Q22F7QGB
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263102
PNG
(US9708359, 27)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](COCc4ccccc4)[C@@H](O)[C@H]3O)c2n1)C#N
Show InChI InChI=1/C20H21N5O4/c1-11-23-18(22)15-13(7-21)8-25(19(15)24-11)20-17(27)16(26)14(29-20)10-28-9-12-5-3-2-4-6-12/h2-6,8,14,16-17,20,26-27H,9-10H2,1H3,(H2,22,23,24)/t14-,16-,17-,20-/s2
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
BindingDB Entry DOI: 10.7270/Q22F7QGB
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263095
PNG
(US9708359, 16 | US9708359, 28)
Show SMILES NC(=S)c1cn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c2nc(nc(N)c12)-c1ccccc1
Show InChI InChI=1/C18H19N5O4S/c19-14-11-9(15(20)28)6-23(18-13(26)12(25)10(7-24)27-18)17(11)22-16(21-14)8-4-2-1-3-5-8/h1-6,10,12-13,18,24-26H,7H2,(H2,20,28)(H2,19,21,22)/t10-,12-,13-,18-/s2
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
BindingDB Entry DOI: 10.7270/Q22F7QGB
More data for this
Ligand-Target Pair
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