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Compile Data Set for Download or QSAR

Found 143 hits from Chimerix, Inc.; The Regents of the University of Michigan   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Norovirus Polymerase


(Murine norovirus 1)
BDBM263072
PNG
(US9708359, 1 | US9708359, 122 | US9708359, 38 | US...)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1)C(N)=O
Show InChI InChI=1S/C13H17N5O5/c1-4-16-10(14)7-5(11(15)22)2-18(12(7)17-4)13-9(21)8(20)6(3-19)23-13/h2,6,8-9,13,19-21H,3H2,1H3,(H2,15,22)(H2,14,16,17)/t6-,8-,9-,13-/m1/s1
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n/an/an/an/a 2.65E+3n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263073
PNG
(US9708359, 2)
Show SMILES CC(C)[C@H](N)C(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12
Show InChI InChI=1S/C18H26N6O6/c1-6(2)11(19)18(28)29-5-9-12(25)13(26)17(30-9)24-4-8(15(21)27)10-14(20)22-7(3)23-16(10)24/h4,6,9,11-13,17,25-26H,5,19H2,1-3H3,(H2,21,27)(H2,20,22,23)/t9-,11+,12-,13-,17-/m1/s1
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n/an/an/an/a 3.03E+3n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263074
PNG
(US9708359, 3)
Show SMILES C[C@H](N)C(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12
Show InChI InChI=1S/C16H22N6O6/c1-5(17)16(26)27-4-8-10(23)11(24)15(28-8)22-3-7(13(19)25)9-12(18)20-6(2)21-14(9)22/h3,5,8,10-11,15,23-24H,4,17H2,1-2H3,(H2,19,25)(H2,18,20,21)/t5-,8+,10+,11+,15+/m0/s1
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n/an/an/an/a 2.00E+3n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263075
PNG
(US9708359, 4)
Show SMILES CCCCCCCCCCCCCCCCOCCC(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12
Show InChI InChI=1S/C32H53N5O7/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-18-42-19-17-25(38)43-21-24-27(39)28(40)32(44-24)37-20-23(30(34)41)26-29(33)35-22(2)36-31(26)37/h20,24,27-28,32,39-40H,3-19,21H2,1-2H3,(H2,34,41)(H2,33,35,36)/t24-,27-,28-,32-/m1/s1
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n/an/an/an/a 3.50E+3n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263076
PNG
(US9708359, 5)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](COC(=O)[C@@H](N)Cc4ccccc4)[C@@H](O)[C@H]3O)c2n1)C(N)=O
Show InChI InChI=1S/C22H26N6O6/c1-10-26-18(24)15-12(19(25)31)8-28(20(15)27-10)21-17(30)16(29)14(34-21)9-33-22(32)13(23)7-11-5-3-2-4-6-11/h2-6,8,13-14,16-17,21,29-30H,7,9,23H2,1H3,(H2,25,31)(H2,24,26,27)/t13-,14+,16+,17+,21+/m0/s1
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n/an/an/an/a 2.20E+3n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263072
PNG
(US9708359, 1 | US9708359, 122 | US9708359, 38 | US...)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1)C(N)=O
Show InChI InChI=1S/C13H17N5O5/c1-4-16-10(14)7-5(11(15)22)2-18(12(7)17-4)13-9(21)8(20)6(3-19)23-13/h2,6,8-9,13,19-21H,3H2,1H3,(H2,15,22)(H2,14,16,17)/t6-,8-,9-,13-/m1/s1
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n/an/an/an/a 3.08E+3n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263078
PNG
(US9708359, 71)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)c2n1)C(N)=O
Show InChI InChI=1S/C13H18N5O8P/c1-4-16-10(14)7-5(11(15)21)2-18(12(7)17-4)13-9(20)8(19)6(26-13)3-25-27(22,23)24/h2,6,8-9,13,19-20H,3H2,1H3,(H2,15,21)(H2,14,16,17)(H2,22,23,24)/t6-,8-,9-,13-/m1/s1
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n/an/an/an/a 3.15E+3n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263079
PNG
(US9708359, 77)
Show SMILES CC(C)C[C@H](N)C(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12
Show InChI InChI=1S/C19H28N6O6/c1-7(2)4-10(20)19(29)30-6-11-13(26)14(27)18(31-11)25-5-9(16(22)28)12-15(21)23-8(3)24-17(12)25/h5,7,10-11,13-14,18,26-27H,4,6,20H2,1-3H3,(H2,22,28)(H2,21,23,24)/t10-,11+,13+,14+,18+/m0/s1
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n/an/an/an/a 4.40E+3n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263080
PNG
(US9708359, 76)
Show SMILES CC(C)C[C@H](NC(=O)OCC1c2ccccc2-c2ccccc12)C(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12
Show InChI InChI=1S/C34H38N6O8/c1-16(2)12-24(39-34(45)47-14-23-20-10-6-4-8-18(20)19-9-5-7-11-21(19)23)33(44)46-15-25-27(41)28(42)32(48-25)40-13-22(30(36)43)26-29(35)37-17(3)38-31(26)40/h4-11,13,16,23-25,27-28,32,41-42H,12,14-15H2,1-3H3,(H2,36,43)(H,39,45)(H2,35,37,38)/t24-,25+,27+,28+,32+/m0/s1
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n/an/an/an/a 1.64E+4n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263081
PNG
(US9708359, 107)
Show SMILES C[C@H](NP(=O)(OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12)Oc1ccccc1)C(=O)OCc1ccccc1
Show InChI InChI=1S/C29H33N6O9P/c1-16(29(39)41-14-18-9-5-3-6-10-18)34-45(40,44-19-11-7-4-8-12-19)42-15-21-23(36)24(37)28(43-21)35-13-20(26(31)38)22-25(30)32-17(2)33-27(22)35/h3-13,16,21,23-24,28,36-37H,14-15H2,1-2H3,(H2,31,38)(H,34,40)(H2,30,32,33)/t16-,21+,23+,24+,28+,45?/m0/s1
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n/an/an/an/a 1.81E+4n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263082
PNG
(US9708359, 111)
Show SMILES COC(=O)[C@H](C)NP(=O)(OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12)Oc1ccccc1
Show InChI InChI=1S/C23H29N6O9P/c1-11(23(33)35-3)28-39(34,38-13-7-5-4-6-8-13)36-10-15-17(30)18(31)22(37-15)29-9-14(20(25)32)16-19(24)26-12(2)27-21(16)29/h4-9,11,15,17-18,22,30-31H,10H2,1-3H3,(H2,25,32)(H,28,34)(H2,24,26,27)/t11-,15+,17+,18+,22+,39?/m0/s1
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n/an/an/an/a 2.10E+4n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263083
PNG
(US9708359, 126)
Show SMILES C[C@@H](NP(=O)(N[C@@H](C)C(=O)OCc1ccccc1)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12)C(=O)OCc1ccccc1
Show InChI InChI=1S/C33H40N7O10P/c1-18(32(44)47-15-21-10-6-4-7-11-21)38-51(46,39-19(2)33(45)48-16-22-12-8-5-9-13-22)49-17-24-26(41)27(42)31(50-24)40-14-23(29(35)43)25-28(34)36-20(3)37-30(25)40/h4-14,18-19,24,26-27,31,41-42H,15-17H2,1-3H3,(H2,35,43)(H2,34,36,37)(H2,38,39,46)/t18-,19+,24-,26-,27-,31-,51?/m1/s1
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n/an/an/an/a 3.36E+4n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263083
PNG
(US9708359, 126)
Show SMILES C[C@@H](NP(=O)(N[C@@H](C)C(=O)OCc1ccccc1)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12)C(=O)OCc1ccccc1
Show InChI InChI=1S/C33H40N7O10P/c1-18(32(44)47-15-21-10-6-4-7-11-21)38-51(46,39-19(2)33(45)48-16-22-12-8-5-9-13-22)49-17-24-26(41)27(42)31(50-24)40-14-23(29(35)43)25-28(34)36-20(3)37-30(25)40/h4-14,18-19,24,26-27,31,41-42H,15-17H2,1-3H3,(H2,35,43)(H2,34,36,37)(H2,38,39,46)/t18-,19+,24-,26-,27-,31-,51?/m1/s1
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n/an/an/an/a 3.89E+4n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263084
PNG
(US9708359, 133)
Show SMILES CC(C)OC(=O)[C@H](C)NP(=O)(OC[C@H]1O[C@H]([C@H](OC(=O)C(C)C)[C@@H]1OC(=O)C(C)C)n1cc(C(N)=O)c2c(N)nc(C)nc12)Oc1ccccc1
Show InChI InChI=1S/C33H45N6O11P/c1-16(2)31(41)48-25-23(15-45-51(44,50-21-12-10-9-11-13-21)38-19(7)33(43)46-18(5)6)47-30(26(25)49-32(42)17(3)4)39-14-22(28(35)40)24-27(34)36-20(8)37-29(24)39/h9-14,16-19,23,25-26,30H,15H2,1-8H3,(H2,35,40)(H,38,44)(H2,34,36,37)/t19-,23+,25+,26+,30+,51?/m0/s1
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n/an/an/an/a 2.57E+4n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263085
PNG
(US9708359, 137)
Show SMILES CC(C)OC(=O)[C@H](C)NP(=O)(OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12)OCc1ccccc1C
Show InChI InChI=1S/C27H37N6O9P/c1-13(2)41-27(37)15(4)32-43(38,39-11-17-9-7-6-8-14(17)3)40-12-19-21(34)22(35)26(42-19)33-10-18(24(29)36)20-23(28)30-16(5)31-25(20)33/h6-10,13,15,19,21-22,26,34-35H,11-12H2,1-5H3,(H2,29,36)(H,32,38)(H2,28,30,31)/t15-,19+,21+,22+,26+,43?/m0/s1
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n/an/an/an/a 2.00E+4n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263086
PNG
(US9708359, 139)
Show SMILES CCCCCCCCCCCCCCCCOCCCOC(=O)[C@H](C)NP(=O)(OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12)Oc1ccccc1
Show InChI InChI=1S/C41H65N6O10P/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-20-24-53-25-21-26-54-41(51)29(2)46-58(52,57-31-22-18-17-19-23-31)55-28-33-35(48)36(49)40(56-33)47-27-32(38(43)50)34-37(42)44-30(3)45-39(34)47/h17-19,22-23,27,29,33,35-36,40,48-49H,4-16,20-21,24-26,28H2,1-3H3,(H2,43,50)(H,46,52)(H2,42,44,45)/t29-,33+,35+,36+,40+,58?/m0/s1
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n/an/an/an/a 2.30E+3n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263087
PNG
(US9708359, 141)
Show SMILES CC(C)OC(=O)[C@H](C)NP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12
Show InChI InChI=1S/C19H29N6O9P/c1-7(2)33-19(29)8(3)24-35(30,31)32-6-11-13(26)14(27)18(34-11)25-5-10(16(21)28)12-15(20)22-9(4)23-17(12)25/h5,7-8,11,13-14,18,26-27H,6H2,1-4H3,(H2,21,28)(H2,20,22,23)(H2,24,30,31)/t8-,11+,13+,14+,18+/m0/s1
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n/an/an/an/a 3.20E+3n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263088
PNG
(US9708359, 143)
Show SMILES CCCCCCCCCCCCCCCCOCCCOC(=O)[C@H](C)NP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(C(N)=O)c2c(N)nc(C)nc12
Show InChI InChI=1S/C35H61N6O10P/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-19-48-20-18-21-49-35(45)24(2)40-52(46,47)50-23-27-29(42)30(43)34(51-27)41-22-26(32(37)44)28-31(36)38-25(3)39-33(28)41/h22,24,27,29-30,34,42-43H,4-21,23H2,1-3H3,(H2,37,44)(H2,36,38,39)(H2,40,46,47)/t24-,27+,29+,30+,34+/m0/s1
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n/an/an/an/a 2.63E+4n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263089
PNG
(US9708359, 145)
Show SMILES CCCCCCCCC(=O)Oc1ccc(COP(=O)(OCc2ccc(OC(=O)CCCCCCCC)cc2)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2cc(C(N)=O)c3c(N)nc(C)nc23)cc1
Show InChI InChI=1S/C45H63N5O15P2/c1-4-6-8-10-12-14-16-37(51)62-33-22-18-31(19-23-33)27-60-67(58,61-28-32-20-24-34(25-21-32)63-38(52)17-15-13-11-9-7-5-2)65-66(56,57)59-29-36-40(53)41(54)45(64-36)50-26-35(43(47)55)39-42(46)48-30(3)49-44(39)50/h18-26,36,40-41,45,53-54H,4-17,27-29H2,1-3H3,(H2,47,55)(H,56,57)(H2,46,48,49)/t36-,40-,41-,45-/m1/s1
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n/an/an/an/a 7.40E+3n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263090
PNG
(US9708359, 7)
Show SMILES Cc1nc(O)c2c(cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1)C(N)=O
Show InChI InChI=1S/C13H16N4O6/c1-4-15-11-7(12(22)16-4)5(10(14)21)2-17(11)13-9(20)8(19)6(3-18)23-13/h2,6,8-9,13,18-20H,3H2,1H3,(H2,14,21)(H,15,16,22)/t6-,8-,9-,13-/m1/s1
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n/an/an/an/a 5.38E+4n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263091
PNG
(US9708359, 8)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2[n+]1[O-])C(N)=O
Show InChI InChI=1S/C13H17N5O6/c1-4-16-10(14)7-5(11(15)22)2-17(12(7)18(4)23)13-9(21)8(20)6(3-19)24-13/h2,6,8-9,13,19-21H,3H2,1H3,(H2,14,16)(H2,15,22)/t6-,8-,9-,13-/m1/s1
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n/an/an/an/a 2.36E+4n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263092
PNG
(US9708359, 10)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1)-c1nn[nH]n1
Show InChI InChI=1S/C13H16N8O4/c1-4-15-10(14)7-5(11-17-19-20-18-11)2-21(12(7)16-4)13-9(24)8(23)6(3-22)25-13/h2,6,8-9,13,22-24H,3H2,1H3,(H2,14,15,16)(H,17,18,19,20)/t6-,8-,9-,13-/m1/s1
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n/an/an/an/a 6.15E+4n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263093
PNG
(US9708359, 11)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1)C#N
Show InChI InChI=1S/C13H15N5O4/c1-5-16-11(15)8-6(2-14)3-18(12(8)17-5)13-10(21)9(20)7(4-19)22-13/h3,7,9-10,13,19-21H,4H2,1H3,(H2,15,16,17)/t7-,9-,10-,13-/m1/s1
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n/an/an/an/a>1.21E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263094
PNG
(US9708359, 14)
Show SMILES Cc1nc(N)c2c(I)cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1
Show InChI InChI=1S/C12H15IN4O4/c1-4-15-10(14)7-5(13)2-17(11(7)16-4)12-9(20)8(19)6(3-18)21-12/h2,6,8-9,12,18-20H,3H2,1H3,(H2,14,15,16)/t6-,8-,9-,12-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263095
PNG
(US9708359, 16 | US9708359, 28)
Show SMILES NC(=S)c1cn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c2nc(nc(N)c12)-c1ccccc1
Show InChI InChI=1S/C18H19N5O4S/c19-14-11-9(15(20)28)6-23(18-13(26)12(25)10(7-24)27-18)17(11)22-16(21-14)8-4-2-1-3-5-8/h1-6,10,12-13,18,24-26H,7H2,(H2,20,28)(H2,19,21,22)/t10-,12-,13-,18-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263096
PNG
(US9708359, 17)
Show SMILES Nc1nc(nc2n(cc(C#N)c12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O)-c1ccccc1
Show InChI InChI=1S/C18H17N5O4/c19-6-10-7-23(18-14(26)13(25)11(8-24)27-18)17-12(10)15(20)21-16(22-17)9-4-2-1-3-5-9/h1-5,7,11,13-14,18,24-26H,8H2,(H2,20,21,22)/t11-,13-,14-,18-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263097
PNG
(US9708359, 18)
Show SMILES NC(=O)c1cn([C@@H]2O[C@H](COCc3ccccc3)[C@@H](O)[C@H]2O)c2nc(nc(N)c12)-c1ccccc1
Show InChI InChI=1S/C25H25N5O5/c26-21-18-16(22(27)33)11-30(24(18)29-23(28-21)15-9-5-2-6-10-15)25-20(32)19(31)17(35-25)13-34-12-14-7-3-1-4-8-14/h1-11,17,19-20,25,31-32H,12-13H2,(H2,27,33)(H2,26,28,29)/t17-,19-,20-,25-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263098
PNG
(US9708359, 19)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](COCc4ccccc4)[C@@H](O)[C@H]3O)c2n1)C(N)=O
Show InChI InChI=1S/C20H23N5O5/c1-10-23-17(21)14-12(18(22)28)7-25(19(14)24-10)20-16(27)15(26)13(30-20)9-29-8-11-5-3-2-4-6-11/h2-7,13,15-16,20,26-27H,8-9H2,1H3,(H2,22,28)(H2,21,23,24)/t13-,15-,16-,20-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263099
PNG
(US9708359, 20)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](CO)[C@H]4OC(C)(C)O[C@@H]34)c2n1)C(N)=O
Show InChI InChI=1S/C16H21N5O5/c1-6-19-12(17)9-7(13(18)23)4-21(14(9)20-6)15-11-10(8(5-22)24-15)25-16(2,3)26-11/h4,8,10-11,15,22H,5H2,1-3H3,(H2,18,23)(H2,17,19,20)/t8-,10-,11-,15-/m1/s1
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n/an/an/an/a>2.00E+4n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263100
PNG
(US9708359, 21)
Show SMILES CCOP(=O)(COC[C@H]1O[C@H]([C@@H]2OC(C)(C)O[C@H]12)n1cc(C(N)=O)c2c(N)nc(C)nc12)OCC
Show InChI InChI=1S/C21H32N5O8P/c1-6-30-35(28,31-7-2)10-29-9-13-15-16(34-21(4,5)33-15)20(32-13)26-8-12(18(23)27)14-17(22)24-11(3)25-19(14)26/h8,13,15-16,20H,6-7,9-10H2,1-5H3,(H2,23,27)(H2,22,24,25)/t13-,15-,16-,20-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263101
PNG
(US9708359, 22)
Show SMILES CCCCCCCCCCCCCCCOCCCOP(O)(=O)COC[C@H]1O[C@H]([C@@H]2OC(C)(C)O[C@H]12)n1cc(C(N)=O)c2c(N)nc(C)nc12
Show InChI InChI=1S/C35H60N5O9P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-19-44-20-18-21-46-50(42,43)24-45-23-27-29-30(49-35(3,4)48-29)34(47-27)40-22-26(32(37)41)28-31(36)38-25(2)39-33(28)40/h22,27,29-30,34H,5-21,23-24H2,1-4H3,(H2,37,41)(H,42,43)(H2,36,38,39)/t27-,29-,30-,34-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263102
PNG
(US9708359, 27)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](COCc4ccccc4)[C@@H](O)[C@H]3O)c2n1)C#N
Show InChI InChI=1S/C20H21N5O4/c1-11-23-18(22)15-13(7-21)8-25(19(15)24-11)20-17(27)16(26)14(29-20)10-28-9-12-5-3-2-4-6-12/h2-6,8,14,16-17,20,26-27H,9-10H2,1H3,(H2,22,23,24)/t14-,16-,17-,20-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263095
PNG
(US9708359, 16 | US9708359, 28)
Show SMILES NC(=S)c1cn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c2nc(nc(N)c12)-c1ccccc1
Show InChI InChI=1S/C18H19N5O4S/c19-14-11-9(15(20)28)6-23(18-13(26)12(25)10(7-24)27-18)17(11)22-16(21-14)8-4-2-1-3-5-8/h1-6,10,12-13,18,24-26H,7H2,(H2,20,28)(H2,19,21,22)/t10-,12-,13-,18-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263104
PNG
(US9708359, 29)
Show SMILES Cc1nc(Cl)c2c(cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1)C#N
Show InChI InChI=1S/C13H13ClN4O4/c1-5-16-11(14)8-6(2-15)3-18(12(8)17-5)13-10(21)9(20)7(4-19)22-13/h3,7,9-10,13,19-21H,4H2,1H3/t7-,9-,10-,13-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263105
PNG
(US9708359, 30)
Show SMILES COc1nc(C)nc2n(cc(C#N)c12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C14H16N4O5/c1-6-16-12-9(13(17-6)22-2)7(3-15)4-18(12)14-11(21)10(20)8(5-19)23-14/h4,8,10-11,14,19-21H,5H2,1-2H3/t8-,10-,11-,14-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263106
PNG
(US9708359, 31)
Show SMILES Cc1nc(O)c2c(cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1)C#N
Show InChI InChI=1S/C13H14N4O5/c1-5-15-11-8(12(21)16-5)6(2-14)3-17(11)13-10(20)9(19)7(4-18)22-13/h3,7,9-10,13,18-20H,4H2,1H3,(H,15,16,21)/t7-,9-,10-,13-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263107
PNG
(US9708359, 32)
Show SMILES Cc1nc(N)c2c(cnc2n1)C(N)=O
Show InChI InChI=1S/C8H8N5O/c1-3-12-6(9)5-4(7(10)14)2-11-8(5)13-3/h2H,1H3,(H2,10,14)(H2,9,11,12,13)
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263108
PNG
(US9708359, 33)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](COCc4ccccc4)[C@@H](O)[C@H]3O)c2n1)C(O)=O
Show InChI InChI=1S/C20H22N4O6/c1-10-22-17(21)14-12(20(27)28)7-24(18(14)23-10)19-16(26)15(25)13(30-19)9-29-8-11-5-3-2-4-6-11/h2-7,13,15-16,19,25-26H,8-9H2,1H3,(H,27,28)(H2,21,22,23)/t13-,15-,16-,19-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263109
PNG
(US9708359, 34)
Show SMILES Cc1ncc2c(cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1)C(O)=O
Show InChI InChI=1S/C13H15N3O6/c1-5-14-2-6-7(13(20)21)3-16(11(6)15-5)12-10(19)9(18)8(4-17)22-12/h2-3,8-10,12,17-19H,4H2,1H3,(H,20,21)/t8-,9-,10-,12-/m1/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263110
PNG
(US9708359, 35)
Show SMILES Cc1ncc2c(cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1)C(N)=O
Show InChI InChI=1S/C13H16N4O5/c1-5-15-2-6-7(11(14)21)3-17(12(6)16-5)13-10(20)9(19)8(4-18)22-13/h2-3,8-10,13,18-20H,4H2,1H3,(H2,14,21)/t8-,9-,10-,13-/m1/s1
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Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263111
PNG
(US9708359, 36)
Show SMILES CNc1nc(C)nc2n(cc(C(N)=O)c12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C14H19N5O5/c1-5-17-12(16-2)8-6(11(15)23)3-19(13(8)18-5)14-10(22)9(21)7(4-20)24-14/h3,7,9-10,14,20-22H,4H2,1-2H3,(H2,15,23)(H,16,17,18)/t7-,9-,10-,14-/m1/s1
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Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263112
PNG
(US9708359, 37)
Show SMILES CN(C)c1nc(C)nc2n(cc(C(N)=O)c12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C15H21N5O5/c1-6-17-13(19(2)3)9-7(12(16)24)4-20(14(9)18-6)15-11(23)10(22)8(5-21)25-15/h4,8,10-11,15,21-23H,5H2,1-3H3,(H2,16,24)/t8-,10-,11-,15-/m1/s1
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Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263072
PNG
(US9708359, 1 | US9708359, 122 | US9708359, 38 | US...)
Show SMILES Cc1nc(N)c2c(cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1)C(N)=O
Show InChI InChI=1S/C13H17N5O5/c1-4-16-10(14)7-5(11(15)22)2-18(12(7)17-4)13-9(21)8(20)6(3-19)23-13/h2,6,8-9,13,19-21H,3H2,1H3,(H2,15,22)(H2,14,16,17)/t6-,8-,9-,13-/m1/s1
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Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263114
PNG
(US9708359, 39)
Show SMILES CNC(=O)c1cn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c2nc(C)nc(N)c12
Show InChI InChI=1S/C14H19N5O5/c1-5-17-11(15)8-6(13(23)16-2)3-19(12(8)18-5)14-10(22)9(21)7(4-20)24-14/h3,7,9-10,14,20-22H,4H2,1-2H3,(H,16,23)(H2,15,17,18)/t7-,9-,10-,14-/m1/s1
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Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263115
PNG
(US9708359, 41)
Show SMILES CN(C)C(=O)c1cn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c2nc(C)nc(N)c12
Show InChI InChI=1S/C15H21N5O5/c1-6-17-12(16)9-7(14(24)19(2)3)4-20(13(9)18-6)15-11(23)10(22)8(5-21)25-15/h4,8,10-11,15,21-23H,5H2,1-3H3,(H2,16,17,18)/t8-,10-,11-,15-/m1/s1
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Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263116
PNG
(US9708359, 42)
Show SMILES COc1nc(C)nc2n(cc(I)c12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C13H16IN3O5/c1-5-15-11-8(12(16-5)21-2)6(14)3-17(11)13-10(20)9(19)7(4-18)22-13/h3,7,9-10,13,18-20H,4H2,1-2H3/t7-,9-,10-,13-/m1/s1
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Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263117
PNG
(US9708359, 43)
Show SMILES CSc1nc(C)nc2n(cc(I)c12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C13H16IN3O4S/c1-5-15-11-8(12(16-5)22-2)6(14)3-17(11)13-10(20)9(19)7(4-18)21-13/h3,7,9-10,13,18-20H,4H2,1-2H3/t7-,9-,10-,13-/m1/s1
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Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263118
PNG
(US9708359, 44)
Show SMILES Cc1nc(N)c2c(C(N)=O)c(Br)n([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1
Show InChI InChI=1S/C13H16BrN5O5/c1-3-17-10(15)6-5(11(16)23)9(14)19(12(6)18-3)13-8(22)7(21)4(2-20)24-13/h4,7-8,13,20-22H,2H2,1H3,(H2,16,23)(H2,15,17,18)/t4-,7-,8-,13-/m1/s1
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Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263119
PNG
(US9708359, 45)
Show SMILES COC(=O)c1cnc2nc(C)nc(Cl)c12
Show InChI InChI=1S/C9H7ClN3O2/c1-4-12-7(10)6-5(9(14)15-2)3-11-8(6)13-4/h3H,1-2H3
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Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
Norovirus Polymerase


(Murine norovirus 1)
BDBM263120
PNG
(US9708359, 46)
Show SMILES Cc1nc(N)c2ccnc2n1
PDB

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Chimerix, Inc.; The Regents of the University of Michigan

US Patent


Assay Description
Polymerase reactions (10 μL) were conducted for 60 minutes at 37 C. Nucleoside triphosphates (NTPs) were present at 100 μM each, with 0.05...


US Patent US9708359 (2017)


Article DOI: 10.1021/jm0500931
More data for this
Ligand-Target Pair
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