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Compile Data Set for Download or QSAR

Found 92 hits from Chugai Pharmaceutical Co, Ltd   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50306682
PNG
((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Show SMILES C[C@@H](Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1
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n/an/a 8n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50306684
PNG
(2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Show SMILES C[C@@H](Oc1ccc2ncc(cc2c1)C1CC1C(N)=O)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C21H17Cl2FN2O2/c1-10(19-16(22)3-4-17(24)20(19)23)28-13-2-5-18-11(7-13)6-12(9-26-18)14-8-15(14)21(25)27/h2-7,9-10,14-15H,8H2,1H3,(H2,25,27)/t10-,14?,15?/m1/s1
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n/an/a 9.30n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50306677
PNG
((R)-3-(6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Show SMILES C[C@@H](Oc1ccc2ncc(\C=C\C(N)=O)cc2c1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C20H15Cl2FN2O2/c1-11(19-15(21)4-5-16(23)20(19)22)27-14-3-6-17-13(9-14)8-12(10-25-17)2-7-18(24)26/h2-11H,1H3,(H2,24,26)/b7-2+/t11-/m1/s1
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n/an/a 20n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50306677
PNG
((R)-3-(6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Show SMILES C[C@@H](Oc1ccc2ncc(\C=C\C(N)=O)cc2c1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C20H15Cl2FN2O2/c1-11(19-15(21)4-5-16(23)20(19)22)27-14-3-6-17-13(9-14)8-12(10-25-17)2-7-18(24)26/h2-11H,1H3,(H2,24,26)/b7-2+/t11-/m1/s1
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n/an/a 23n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50306680
PNG
(CHEMBL598912 | rac-3-(6-(1-(2,6-dichloro-3-fluorop...)
Show SMILES CNC(=O)\C=C\c1cnc2ccc(OC(C)c3c(Cl)ccc(F)c3Cl)cc2c1
Show InChI InChI=1S/C21H17Cl2FN2O2/c1-12(20-16(22)5-6-17(24)21(20)23)28-15-4-7-18-14(10-15)9-13(11-26-18)3-8-19(27)25-2/h3-12H,1-2H3,(H,25,27)/b8-3+
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n/an/a 28n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50306679
PNG
(CHEMBL608738 | rac-3-(6-(1-(2,6-dichloro-3-fluorop...)
Show SMILES CC(Oc1ccc2ncc(\C=C\C(=O)N(C)C)cc2c1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C22H19Cl2FN2O2/c1-13(21-17(23)6-7-18(25)22(21)24)29-16-5-8-19-15(11-16)10-14(12-26-19)4-9-20(28)27(2)3/h4-13H,1-3H3/b9-4+
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n/an/a 59n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50306685
PNG
(CHEMBL602470 | rac-3-(6-(1-(2,6-dichloro-3-fluorop...)
Show SMILES CC(Oc1ccc2ncc(\C=C\C(O)=O)cc2c1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C20H14Cl2FNO3/c1-11(19-15(21)4-5-16(23)20(19)22)27-14-3-6-17-13(9-14)8-12(10-24-17)2-7-18(25)26/h2-11H,1H3,(H,25,26)/b7-2+
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n/an/a 94n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50306683
PNG
((R)-6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)quino...)
Show SMILES C[C@@H](Oc1ccc2ncccc2c1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C17H12Cl2FNO/c1-10(16-13(18)5-6-14(20)17(16)19)22-12-4-7-15-11(9-12)3-2-8-21-15/h2-10H,1H3/t10-/m1/s1
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n/an/a 130n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50306678
PNG
(CHEMBL591457 | rac-3-(6-(1-(2,6-dichloro-3-fluorop...)
Show SMILES CC(Oc1ccc2ncc(CCC(N)=O)cc2c1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C20H17Cl2FN2O2/c1-11(19-15(21)4-5-16(23)20(19)22)27-14-3-6-17-13(9-14)8-12(10-25-17)2-7-18(24)26/h3-6,8-11H,2,7H2,1H3,(H2,24,26)
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n/an/a 205n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50306684
PNG
(2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Show SMILES C[C@@H](Oc1ccc2ncc(cc2c1)C1CC1C(N)=O)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C21H17Cl2FN2O2/c1-10(19-16(22)3-4-17(24)20(19)23)28-13-2-5-18-11(7-13)6-12(9-26-18)14-8-15(14)21(25)27/h2-7,9-10,14-15H,8H2,1H3,(H2,25,27)/t10-,14?,15?/m1/s1
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n/an/a 230n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant RON by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50306686
PNG
(CHEMBL599993 | rac-3-(6-(1-(2,6-dichloro-3-fluorop...)
Show SMILES CC(Oc1ccc2ncc(\C=C\CN)cc2c1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C20H17Cl2FN2O/c1-12(19-16(21)5-6-17(23)20(19)22)26-15-4-7-18-14(10-15)9-13(11-25-18)3-2-8-24/h2-7,9-12H,8,24H2,1H3/b3-2+
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n/an/a 368n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
AXL receptor tyrosine kinase


(Homo sapiens (Human))
BDBM50306684
PNG
(2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Show SMILES C[C@@H](Oc1ccc2ncc(cc2c1)C1CC1C(N)=O)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C21H17Cl2FN2O2/c1-10(19-16(22)3-4-17(24)20(19)23)28-13-2-5-18-11(7-13)6-12(9-26-18)14-8-15(14)21(25)27/h2-7,9-10,14-15H,8H2,1H3,(H2,25,27)/t10-,14?,15?/m1/s1
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n/an/a 430n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant AXL by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50306677
PNG
((R)-3-(6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Show SMILES C[C@@H](Oc1ccc2ncc(\C=C\C(N)=O)cc2c1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C20H15Cl2FN2O2/c1-11(19-15(21)4-5-16(23)20(19)22)27-14-3-6-17-13(9-14)8-12(10-25-17)2-7-18(24)26/h2-11H,1H3,(H2,24,26)/b7-2+/t11-/m1/s1
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n/an/a 450n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant RON by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50306681
PNG
((S)-6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)quino...)
Show SMILES C[C@H](Oc1ccc2ncccc2c1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C17H12Cl2FNO/c1-10(16-13(18)5-6-14(20)17(16)19)22-12-4-7-15-11(9-12)3-2-8-21-15/h2-10H,1H3/t10-/m0/s1
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n/an/a 453n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
AXL receptor tyrosine kinase


(Homo sapiens (Human))
BDBM50306677
PNG
((R)-3-(6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Show SMILES C[C@@H](Oc1ccc2ncc(\C=C\C(N)=O)cc2c1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C20H15Cl2FN2O2/c1-11(19-15(21)4-5-16(23)20(19)22)27-14-3-6-17-13(9-14)8-12(10-25-17)2-7-18(24)26/h2-11H,1H3,(H2,24,26)/b7-2+/t11-/m1/s1
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n/an/a 570n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant AXL by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50306681
PNG
((S)-6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)quino...)
Show SMILES C[C@H](Oc1ccc2ncccc2c1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C17H12Cl2FNO/c1-10(16-13(18)5-6-14(20)17(16)19)22-12-4-7-15-11(9-12)3-2-8-21-15/h2-10H,1H3/t10-/m0/s1
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n/an/a 1.20E+3n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
Macrophage-stimulating protein receptor


(Homo sapiens (Human))
BDBM50306683
PNG
((R)-6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)quino...)
Show SMILES C[C@@H](Oc1ccc2ncccc2c1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C17H12Cl2FNO/c1-10(16-13(18)5-6-14(20)17(16)19)22-12-4-7-15-11(9-12)3-2-8-21-15/h2-10H,1H3/t10-/m1/s1
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n/an/a 3.60E+3n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant RON by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
Ephrin receptor


(Homo sapiens)
BDBM50306677
PNG
((R)-3-(6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Show SMILES C[C@@H](Oc1ccc2ncc(\C=C\C(N)=O)cc2c1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C20H15Cl2FN2O2/c1-11(19-15(21)4-5-16(23)20(19)22)27-14-3-6-17-13(9-14)8-12(10-25-17)2-7-18(24)26/h2-11H,1H3,(H2,24,26)/b7-2+/t11-/m1/s1
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n/an/a 4.40E+3n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant EphA2 by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
Ephrin receptor


(Homo sapiens)
BDBM50306684
PNG
(2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Show SMILES C[C@@H](Oc1ccc2ncc(cc2c1)C1CC1C(N)=O)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C21H17Cl2FN2O2/c1-10(19-16(22)3-4-17(24)20(19)23)28-13-2-5-18-11(7-13)6-12(9-26-18)14-8-15(14)21(25)27/h2-7,9-10,14-15H,8H2,1H3,(H2,25,27)/t10-,14?,15?/m1/s1
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n/an/a 5.20E+3n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant EphA2 by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Aurora


(Homo sapiens (human))
BDBM50306677
PNG
((R)-3-(6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Show SMILES C[C@@H](Oc1ccc2ncc(\C=C\C(N)=O)cc2c1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C20H15Cl2FN2O2/c1-11(19-15(21)4-5-16(23)20(19)22)27-14-3-6-17-13(9-14)8-12(10-25-17)2-7-18(24)26/h2-11H,1H3,(H2,24,26)/b7-2+/t11-/m1/s1
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n/an/a 6.40E+3n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant Aurora A by IMAP assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM50306677
PNG
((R)-3-(6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Show SMILES C[C@@H](Oc1ccc2ncc(\C=C\C(N)=O)cc2c1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C20H15Cl2FN2O2/c1-11(19-15(21)4-5-16(23)20(19)22)27-14-3-6-17-13(9-14)8-12(10-25-17)2-7-18(24)26/h2-11H,1H3,(H2,24,26)/b7-2+/t11-/m1/s1
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n/an/a 6.90E+3n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant FGFR2 by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50306682
PNG
((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Show SMILES C[C@@H](Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant KDR by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))
BDBM50306677
PNG
((R)-3-(6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Show SMILES C[C@@H](Oc1ccc2ncc(\C=C\C(N)=O)cc2c1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C20H15Cl2FN2O2/c1-11(19-15(21)4-5-16(23)20(19)22)27-14-3-6-17-13(9-14)8-12(10-25-17)2-7-18(24)26/h2-11H,1H3,(H2,24,26)/b7-2+/t11-/m1/s1
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n/an/a 1.00E+4n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant Abl by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
Leukocyte tyrosine kinase receptor


(Homo sapiens)
BDBM50306684
PNG
(2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Show SMILES C[C@@H](Oc1ccc2ncc(cc2c1)C1CC1C(N)=O)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C21H17Cl2FN2O2/c1-10(19-16(22)3-4-17(24)20(19)23)28-13-2-5-18-11(7-13)6-12(9-26-18)14-8-15(14)21(25)27/h2-7,9-10,14-15H,8H2,1H3,(H2,25,27)/t10-,14?,15?/m1/s1
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n/an/a 1.00E+4n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant LTK by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50306677
PNG
((R)-3-(6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Show SMILES C[C@@H](Oc1ccc2ncc(\C=C\C(N)=O)cc2c1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C20H15Cl2FN2O2/c1-11(19-15(21)4-5-16(23)20(19)22)27-14-3-6-17-13(9-14)8-12(10-25-17)2-7-18(24)26/h2-11H,1H3,(H2,24,26)/b7-2+/t11-/m1/s1
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n/an/a 1.10E+4n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant KDR by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM50306684
PNG
(2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Show SMILES C[C@@H](Oc1ccc2ncc(cc2c1)C1CC1C(N)=O)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C21H17Cl2FN2O2/c1-10(19-16(22)3-4-17(24)20(19)23)28-13-2-5-18-11(7-13)6-12(9-26-18)14-8-15(14)21(25)27/h2-7,9-10,14-15H,8H2,1H3,(H2,25,27)/t10-,14?,15?/m1/s1
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n/an/a 1.20E+4n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant FGFR2 by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
AXL receptor tyrosine kinase


(Homo sapiens (Human))
BDBM50306683
PNG
((R)-6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)quino...)
Show SMILES C[C@@H](Oc1ccc2ncccc2c1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C17H12Cl2FNO/c1-10(16-13(18)5-6-14(20)17(16)19)22-12-4-7-15-11(9-12)3-2-8-21-15/h2-10H,1H3/t10-/m1/s1
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n/an/a 1.40E+4n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant AXL by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50306677
PNG
((R)-3-(6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Show SMILES C[C@@H](Oc1ccc2ncc(\C=C\C(N)=O)cc2c1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C20H15Cl2FN2O2/c1-11(19-15(21)4-5-16(23)20(19)22)27-14-3-6-17-13(9-14)8-12(10-25-17)2-7-18(24)26/h2-11H,1H3,(H2,24,26)/b7-2+/t11-/m1/s1
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n/an/a 1.40E+4n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant LCK by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50306684
PNG
(2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Show SMILES C[C@@H](Oc1ccc2ncc(cc2c1)C1CC1C(N)=O)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C21H17Cl2FN2O2/c1-10(19-16(22)3-4-17(24)20(19)23)28-13-2-5-18-11(7-13)6-12(9-26-18)14-8-15(14)21(25)27/h2-7,9-10,14-15H,8H2,1H3,(H2,25,27)/t10-,14?,15?/m1/s1
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n/an/a 1.50E+4n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant Flt3 by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
Leukocyte tyrosine kinase receptor


(Homo sapiens)
BDBM50306677
PNG
((R)-3-(6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Show SMILES C[C@@H](Oc1ccc2ncc(\C=C\C(N)=O)cc2c1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C20H15Cl2FN2O2/c1-11(19-15(21)4-5-16(23)20(19)22)27-14-3-6-17-13(9-14)8-12(10-25-17)2-7-18(24)26/h2-11H,1H3,(H2,24,26)/b7-2+/t11-/m1/s1
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n/an/a 1.80E+4n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant LTK by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
VEGF-receptor 2 and tyrosine-protein kinase SRC


(Homo sapiens (Human))
BDBM50306681
PNG
((S)-6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)quino...)
Show SMILES C[C@H](Oc1ccc2ncccc2c1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C17H12Cl2FNO/c1-10(16-13(18)5-6-14(20)17(16)19)22-12-4-7-15-11(9-12)3-2-8-21-15/h2-10H,1H3/t10-/m0/s1
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n/an/a 2.00E+4n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant Src by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Aurora


(Homo sapiens (human))
BDBM50306684
PNG
(2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Show SMILES C[C@@H](Oc1ccc2ncc(cc2c1)C1CC1C(N)=O)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C21H17Cl2FN2O2/c1-10(19-16(22)3-4-17(24)20(19)23)28-13-2-5-18-11(7-13)6-12(9-26-18)14-8-15(14)21(25)27/h2-7,9-10,14-15H,8H2,1H3,(H2,25,27)/t10-,14?,15?/m1/s1
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n/an/a 2.20E+4n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant Aurora A by IMAP assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
VEGF-receptor 2 and tyrosine-protein kinase SRC


(Homo sapiens (Human))
BDBM50306683
PNG
((R)-6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)quino...)
Show SMILES C[C@@H](Oc1ccc2ncccc2c1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C17H12Cl2FNO/c1-10(16-13(18)5-6-14(20)17(16)19)22-12-4-7-15-11(9-12)3-2-8-21-15/h2-10H,1H3/t10-/m1/s1
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n/an/a 2.20E+4n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant Src by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50306683
PNG
((R)-6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)quino...)
Show SMILES C[C@@H](Oc1ccc2ncccc2c1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C17H12Cl2FNO/c1-10(16-13(18)5-6-14(20)17(16)19)22-12-4-7-15-11(9-12)3-2-8-21-15/h2-10H,1H3/t10-/m1/s1
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n/an/a 2.30E+4n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant KDR by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM50306683
PNG
((R)-6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)quino...)
Show SMILES C[C@@H](Oc1ccc2ncccc2c1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C17H12Cl2FNO/c1-10(16-13(18)5-6-14(20)17(16)19)22-12-4-7-15-11(9-12)3-2-8-21-15/h2-10H,1H3/t10-/m1/s1
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n/an/a 2.40E+4n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant FGFR2 by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (Human))
BDBM50306684
PNG
(2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Show SMILES C[C@@H](Oc1ccc2ncc(cc2c1)C1CC1C(N)=O)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C21H17Cl2FN2O2/c1-10(19-16(22)3-4-17(24)20(19)23)28-13-2-5-18-11(7-13)6-12(9-26-18)14-8-15(14)21(25)27/h2-7,9-10,14-15H,8H2,1H3,(H2,25,27)/t10-,14?,15?/m1/s1
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n/an/a 2.50E+4n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant Fyn by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50306677
PNG
((R)-3-(6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Show SMILES C[C@@H](Oc1ccc2ncc(\C=C\C(N)=O)cc2c1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C20H15Cl2FN2O2/c1-11(19-15(21)4-5-16(23)20(19)22)27-14-3-6-17-13(9-14)8-12(10-25-17)2-7-18(24)26/h2-11H,1H3,(H2,24,26)/b7-2+/t11-/m1/s1
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n/an/a 2.60E+4n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant KDR by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Yes


(Homo sapiens (Human))
BDBM50306677
PNG
((R)-3-(6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Show SMILES C[C@@H](Oc1ccc2ncc(\C=C\C(N)=O)cc2c1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C20H15Cl2FN2O2/c1-11(19-15(21)4-5-16(23)20(19)22)27-14-3-6-17-13(9-14)8-12(10-25-17)2-7-18(24)26/h2-11H,1H3,(H2,24,26)/b7-2+/t11-/m1/s1
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n/an/a 2.60E+4n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant YES by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50306684
PNG
(2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Show SMILES C[C@@H](Oc1ccc2ncc(cc2c1)C1CC1C(N)=O)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C21H17Cl2FN2O2/c1-10(19-16(22)3-4-17(24)20(19)23)28-13-2-5-18-11(7-13)6-12(9-26-18)14-8-15(14)21(25)27/h2-7,9-10,14-15H,8H2,1H3,(H2,25,27)/t10-,14?,15?/m1/s1
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n/an/a 2.70E+4n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant IGF1R by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (human))
BDBM50306684
PNG
(2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Show SMILES C[C@@H](Oc1ccc2ncc(cc2c1)C1CC1C(N)=O)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C21H17Cl2FN2O2/c1-10(19-16(22)3-4-17(24)20(19)23)28-13-2-5-18-11(7-13)6-12(9-26-18)14-8-15(14)21(25)27/h2-7,9-10,14-15H,8H2,1H3,(H2,25,27)/t10-,14?,15?/m1/s1
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n/an/a 2.80E+4n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant LCK by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (Human))
BDBM50306677
PNG
((R)-3-(6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Show SMILES C[C@@H](Oc1ccc2ncc(\C=C\C(N)=O)cc2c1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C20H15Cl2FN2O2/c1-11(19-15(21)4-5-16(23)20(19)22)27-14-3-6-17-13(9-14)8-12(10-25-17)2-7-18(24)26/h2-11H,1H3,(H2,24,26)/b7-2+/t11-/m1/s1
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n/an/a 2.80E+4n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant Fyn by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50306681
PNG
((S)-6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)quino...)
Show SMILES C[C@H](Oc1ccc2ncccc2c1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C17H12Cl2FNO/c1-10(16-13(18)5-6-14(20)17(16)19)22-12-4-7-15-11(9-12)3-2-8-21-15/h2-10H,1H3/t10-/m0/s1
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n/an/a 3.20E+4n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant KDR by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50306677
PNG
((R)-3-(6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Show SMILES C[C@@H](Oc1ccc2ncc(\C=C\C(N)=O)cc2c1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C20H15Cl2FN2O2/c1-11(19-15(21)4-5-16(23)20(19)22)27-14-3-6-17-13(9-14)8-12(10-25-17)2-7-18(24)26/h2-11H,1H3,(H2,24,26)/b7-2+/t11-/m1/s1
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n/an/a 3.20E+4n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant Flt3 by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BRK


(Homo sapiens (human))
BDBM50306677
PNG
((R)-3-(6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Show SMILES C[C@@H](Oc1ccc2ncc(\C=C\C(N)=O)cc2c1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C20H15Cl2FN2O2/c1-11(19-15(21)4-5-16(23)20(19)22)27-14-3-6-17-13(9-14)8-12(10-25-17)2-7-18(24)26/h2-11H,1H3,(H2,24,26)/b7-2+/t11-/m1/s1
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n/an/a 3.20E+4n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant BRK by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50306686
PNG
(CHEMBL599993 | rac-3-(6-(1-(2,6-dichloro-3-fluorop...)
Show SMILES CC(Oc1ccc2ncc(\C=C\CN)cc2c1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C20H17Cl2FN2O/c1-12(19-16(21)5-6-17(23)20(19)22)26-15-4-7-18-14(10-15)9-13(11-25-18)3-2-8-24/h2-7,9-12H,8,24H2,1H3/b3-2+
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n/an/a 3.30E+4n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant KDR by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM50306683
PNG
((R)-6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)quino...)
Show SMILES C[C@@H](Oc1ccc2ncccc2c1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C17H12Cl2FNO/c1-10(16-13(18)5-6-14(20)17(16)19)22-12-4-7-15-11(9-12)3-2-8-21-15/h2-10H,1H3/t10-/m1/s1
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n/an/a 4.10E+4n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant Kit by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)


(Homo sapiens (Human))
BDBM50306684
PNG
(2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Show SMILES C[C@@H](Oc1ccc2ncc(cc2c1)C1CC1C(N)=O)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C21H17Cl2FN2O2/c1-10(19-16(22)3-4-17(24)20(19)23)28-13-2-5-18-11(7-13)6-12(9-26-18)14-8-15(14)21(25)27/h2-7,9-10,14-15H,8H2,1H3,(H2,25,27)/t10-,14?,15?/m1/s1
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n/an/a 4.10E+4n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant Kit by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50306683
PNG
((R)-6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)quino...)
Show SMILES C[C@@H](Oc1ccc2ncccc2c1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C17H12Cl2FNO/c1-10(16-13(18)5-6-14(20)17(16)19)22-12-4-7-15-11(9-12)3-2-8-21-15/h2-10H,1H3/t10-/m1/s1
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n/an/a 4.60E+4n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant Flt3 by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
VEGF-receptor 2 and tyrosine-protein kinase SRC


(Homo sapiens (Human))
BDBM50306686
PNG
(CHEMBL599993 | rac-3-(6-(1-(2,6-dichloro-3-fluorop...)
Show SMILES CC(Oc1ccc2ncc(\C=C\CN)cc2c1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C20H17Cl2FN2O/c1-12(19-16(21)5-6-17(23)20(19)22)26-15-4-7-18-14(10-15)9-13(11-25-18)3-2-8-24/h2-7,9-12H,8,24H2,1H3/b3-2+
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n/an/a 4.60E+4n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant Src by TR-FRET assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM50306677
PNG
((R)-3-(6-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)qu...)
Show SMILES C[C@@H](Oc1ccc2ncc(\C=C\C(N)=O)cc2c1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C20H15Cl2FN2O2/c1-11(19-15(21)4-5-16(23)20(19)22)27-14-3-6-17-13(9-14)8-12(10-25-17)2-7-18(24)26/h2-11H,1H3,(H2,24,26)/b7-2+/t11-/m1/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Chugai Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Inhibition of recombinant AKT1 by IMAP assay


Bioorg Med Chem Lett 20: 1405-9 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.109
BindingDB Entry DOI: 10.7270/Q2HQ401G
More data for this
Ligand-Target Pair
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