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Compile Data Set for Download or QSAR

Found 30 hits from Chugai Pharmaceutical Co. Ltd.   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50479835
PNG
(CHEMBL510873)
Show SMILES Cn1cncc1[C@](N)(c1cc2cc(cc(-c3cccc(c3)C#N)c2o1)C#N)c1ccc(cc1)C#N
Show InChI InChI=1S/C28H18N6O/c1-34-17-33-16-25(34)28(32,23-7-5-18(13-29)6-8-23)26-12-22-10-20(15-31)11-24(27(22)35-26)21-4-2-3-19(9-21)14-30/h2-12,16-17H,32H2,1H3/t28-/m0/s1
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n/an/a 0.700n/an/an/an/an/an/a



Chugai Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FTase


Bioorg Med Chem Lett 19: 1753-7 (2009)

More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50479863
PNG
(CHEMBL521743)
Show SMILES COc1cccc(c1)-c1cc(cc2cc(oc12)[C@@](N)(c1cncn1C)c1ccc(cc1)C#N)[N+]([O-])=O
Show InChI InChI=1S/C27H21N5O4/c1-31-16-30-15-24(31)27(29,20-8-6-17(14-28)7-9-20)25-12-19-10-21(32(33)34)13-23(26(19)36-25)18-4-3-5-22(11-18)35-2/h3-13,15-16H,29H2,1-2H3/t27-/m0/s1
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n/an/a 0.800n/an/an/an/an/an/a



Chugai Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FTase


Bioorg Med Chem Lett 19: 1753-7 (2009)

More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50479859
PNG
(CHEMBL508937)
Show SMILES COc1cccc(c1)-c1cc(cc2cc(oc12)C(O)(c1cncn1C)c1ccc(cc1)C#N)C(N)=O
Show InChI InChI=1S/C28H22N4O4/c1-32-16-31-15-24(32)28(34,21-8-6-17(14-29)7-9-21)25-13-19-10-20(27(30)33)12-23(26(19)36-25)18-4-3-5-22(11-18)35-2/h3-13,15-16,34H,1-2H3,(H2,30,33)
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n/an/a 0.900n/an/an/an/an/an/a



Chugai Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FTase


Bioorg Med Chem Lett 19: 1753-7 (2009)

More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50479847
PNG
(CHEMBL514300)
Show SMILES COc1cccc(c1)-c1cc(CO)cc2cc(oc12)C(O)(c1cncn1C)c1ccc(cc1)C#N
Show InChI InChI=1S/C28H23N3O4/c1-31-17-30-15-25(31)28(33,22-8-6-18(14-29)7-9-22)26-13-21-10-19(16-32)11-24(27(21)35-26)20-4-3-5-23(12-20)34-2/h3-13,15,17,32-33H,16H2,1-2H3
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n/an/a 1n/an/an/an/an/an/a



Chugai Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FTase


Bioorg Med Chem Lett 19: 1753-7 (2009)

More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50479856
PNG
(CHEMBL454405)
Show SMILES Cn1cncc1[C@](N)(c1cc2cc(cc(-c3cccc(F)c3)c2o1)C#N)c1ccc(cc1)C#N
Show InChI InChI=1S/C27H18FN5O/c1-33-16-32-15-24(33)27(31,21-7-5-17(13-29)6-8-21)25-12-20-9-18(14-30)10-23(26(20)34-25)19-3-2-4-22(28)11-19/h2-12,15-16H,31H2,1H3/t27-/m0/s1
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n/an/a 1.10n/an/an/an/an/an/a



Chugai Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FTase


Bioorg Med Chem Lett 19: 1753-7 (2009)

More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50479848
PNG
(CHEMBL489318)
Show SMILES COc1cccc(c1)-c1cc(cc2cc(oc12)[C@@](N)(c1cncn1C)c1ccc(cc1)C#N)C#N
Show InChI InChI=1S/C28H21N5O2/c1-33-17-32-16-25(33)28(31,22-8-6-18(14-29)7-9-22)26-13-21-10-19(15-30)11-24(27(21)35-26)20-4-3-5-23(12-20)34-2/h3-13,16-17H,31H2,1-2H3/t28-/m0/s1
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n/an/a 1.20n/an/an/an/an/an/a



Chugai Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FTase


Bioorg Med Chem Lett 19: 1753-7 (2009)

More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50479849
PNG
(CHEMBL489121)
Show SMILES Cn1cncc1[C@](N)(c1cc2cc(cc(-c3ccccc3)c2o1)[N+]([O-])=O)c1ccc(cc1)C#N
Show InChI InChI=1S/C26H19N5O3/c1-30-16-29-15-23(30)26(28,20-9-7-17(14-27)8-10-20)24-12-19-11-21(31(32)33)13-22(25(19)34-24)18-5-3-2-4-6-18/h2-13,15-16H,28H2,1H3/t26-/m0/s1
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n/an/a 1.5n/an/an/an/an/an/a



Chugai Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FTase


Bioorg Med Chem Lett 19: 1753-7 (2009)

More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50479853
PNG
(CHEMBL511113)
Show SMILES COc1cccc(c1)-c1cc(C=O)cc2cc(oc12)C(O)(c1cncn1C)c1ccc(cc1)C#N
Show InChI InChI=1S/C28H21N3O4/c1-31-17-30-15-25(31)28(33,22-8-6-18(14-29)7-9-22)26-13-21-10-19(16-32)11-24(27(21)35-26)20-4-3-5-23(12-20)34-2/h3-13,15-17,33H,1-2H3
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n/an/a 2n/an/an/an/an/an/a



Chugai Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FTase


Bioorg Med Chem Lett 19: 1753-7 (2009)

More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50479850
PNG
(CHEMBL475149)
Show SMILES Cn1cncc1C(O)(c1cc2cc(cc(-c3ccccc3)c2o1)C#N)c1ccc(cc1)C#N
Show InChI InChI=1S/C27H18N4O2/c1-31-17-30-16-24(31)27(32,22-9-7-18(14-28)8-10-22)25-13-21-11-19(15-29)12-23(26(21)33-25)20-5-3-2-4-6-20/h2-13,16-17,32H,1H3
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n/an/a 2.40n/an/an/an/an/an/a



Chugai Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FTase


Bioorg Med Chem Lett 19: 1753-7 (2009)

More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50479864
PNG
(CHEMBL510021)
Show SMILES COc1cccc(c1)-c1cc(cc2cc(oc12)C(O)(c1cncn1C)c1ccc(cc1)C#N)C(=O)NN1CCOCC1
Show InChI InChI=1S/C32H29N5O5/c1-36-20-34-19-28(36)32(39,25-8-6-21(18-33)7-9-25)29-17-23-14-24(31(38)35-37-10-12-41-13-11-37)16-27(30(23)42-29)22-4-3-5-26(15-22)40-2/h3-9,14-17,19-20,39H,10-13H2,1-2H3,(H,35,38)
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n/an/a 2.60n/an/an/an/an/an/a



Chugai Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FTase


Bioorg Med Chem Lett 19: 1753-7 (2009)

More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50479860
PNG
(CHEMBL473148)
Show SMILES Cn1cncc1C(O)(c1cc2cc(cc(-c3cccc(c3)C#N)c2o1)[N+]([O-])=O)c1ccc(cc1)C#N
Show InChI InChI=1S/C27H17N5O4/c1-31-16-30-15-24(31)27(33,21-7-5-17(13-28)6-8-21)25-11-20-10-22(32(34)35)12-23(26(20)36-25)19-4-2-3-18(9-19)14-29/h2-12,15-16,33H,1H3
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n/an/a 2.80n/an/an/an/an/an/a



Chugai Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FTase


Bioorg Med Chem Lett 19: 1753-7 (2009)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50479851
PNG
(CHEMBL462021)
Show SMILES COC(=O)c1cc(-c2cccc(OC)c2)c2oc(cc2c1)C(O)(c1cncn1C)c1ccc(cc1)C#N
Show InChI InChI=1S/C29H23N3O5/c1-32-17-31-16-25(32)29(34,22-9-7-18(15-30)8-10-22)26-14-20-11-21(28(33)36-3)13-24(27(20)37-26)19-5-4-6-23(12-19)35-2/h4-14,16-17,34H,1-3H3
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n/an/a 3.20n/an/an/an/an/an/a



Chugai Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FTase


Bioorg Med Chem Lett 19: 1753-7 (2009)

More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50479857
PNG
(CHEMBL472956)
Show SMILES Cn1cncc1C(O)(c1cc2cc(cc(-c3ccccc3F)c2o1)[N+]([O-])=O)c1ccc(cc1)C#N
Show InChI InChI=1S/C26H17FN4O4/c1-30-15-29-14-23(30)26(32,18-8-6-16(13-28)7-9-18)24-11-17-10-19(31(33)34)12-21(25(17)35-24)20-4-2-3-5-22(20)27/h2-12,14-15,32H,1H3
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n/an/a 3.30n/an/an/an/an/an/a



Chugai Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FTase


Bioorg Med Chem Lett 19: 1753-7 (2009)

More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50479858
PNG
(CHEMBL453395)
Show SMILES Cn1cncc1C(O)(c1cc2cc(cc(-c3ccc(cc3)C#N)c2o1)[N+]([O-])=O)c1ccc(cc1)C#N
Show InChI InChI=1S/C27H17N5O4/c1-31-16-30-15-24(31)27(33,21-8-4-18(14-29)5-9-21)25-11-20-10-22(32(34)35)12-23(26(20)36-25)19-6-2-17(13-28)3-7-19/h2-12,15-16,33H,1H3
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n/an/a 3.40n/an/an/an/an/an/a



Chugai Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FTase


Bioorg Med Chem Lett 19: 1753-7 (2009)

More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50479836
PNG
(CHEMBL511072)
Show SMILES COc1ccc(cc1)-c1cc(cc2cc(oc12)C(O)(c1cncn1C)c1ccc(cc1)C#N)[N+]([O-])=O
Show InChI InChI=1S/C27H20N4O5/c1-30-16-29-15-24(30)27(32,20-7-3-17(14-28)4-8-20)25-12-19-11-21(31(33)34)13-23(26(19)36-25)18-5-9-22(35-2)10-6-18/h3-13,15-16,32H,1-2H3
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n/an/a 4n/an/an/an/an/an/a



Chugai Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FTase


Bioorg Med Chem Lett 19: 1753-7 (2009)

More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50479854
PNG
(CHEMBL453394)
Show SMILES Cn1cncc1C(O)(c1cc2cc(cc(-c3cccc(F)c3)c2o1)[N+]([O-])=O)c1ccc(cc1)C#N
Show InChI InChI=1S/C26H17FN4O4/c1-30-15-29-14-23(30)26(32,19-7-5-16(13-28)6-8-19)24-11-18-10-21(31(33)34)12-22(25(18)35-24)17-3-2-4-20(27)9-17/h2-12,14-15,32H,1H3
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n/an/a 6.30n/an/an/an/an/an/a



Chugai Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FTase


Bioorg Med Chem Lett 19: 1753-7 (2009)

More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50479838
PNG
(CHEMBL513211)
Show SMILES Cn1cncc1C(O)(c1cc2cc(cc(-c3ccccc3)c2o1)C(=O)NN1CCOCC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C30H27ClN4O4/c1-34-19-32-18-26(34)30(37,23-7-9-24(31)10-8-23)27-17-21-15-22(29(36)33-35-11-13-38-14-12-35)16-25(28(21)39-27)20-5-3-2-4-6-20/h2-10,15-19,37H,11-14H2,1H3,(H,33,36)
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n/an/a 6.40n/an/an/an/an/an/a



Chugai Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FTase


Bioorg Med Chem Lett 19: 1753-7 (2009)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50479837
PNG
(CHEMBL516034)
Show SMILES Cn1cncc1C(O)(c1cc2cc(cc(-c3ccccc3)c2o1)[N+]([O-])=O)c1ccc(cc1)C#N
Show InChI InChI=1S/C26H18N4O4/c1-29-16-28-15-23(29)26(31,20-9-7-17(14-27)8-10-20)24-12-19-11-21(30(32)33)13-22(25(19)34-24)18-5-3-2-4-6-18/h2-13,15-16,31H,1H3
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n/an/a 6.40n/an/an/an/an/an/a



Chugai Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FTase


Bioorg Med Chem Lett 19: 1753-7 (2009)

More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50479839
PNG
(CHEMBL517280)
Show SMILES Cn1cncc1C(O)(c1cc2cc(cc(-c3ccc(F)cc3)c2o1)[N+]([O-])=O)c1ccc(cc1)C#N
Show InChI InChI=1S/C26H17FN4O4/c1-30-15-29-14-23(30)26(32,19-6-2-16(13-28)3-7-19)24-11-18-10-21(31(33)34)12-22(25(18)35-24)17-4-8-20(27)9-5-17/h2-12,14-15,32H,1H3
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n/an/a 7.20n/an/an/an/an/an/a



Chugai Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FTase


Bioorg Med Chem Lett 19: 1753-7 (2009)

More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50479861
PNG
(CHEMBL473151)
Show SMILES COc1cccc(c1)-c1cc(cc2cc(oc12)C(O)(c1cncn1C)c1ccc(cc1)C#N)[N+]([O-])=O
Show InChI InChI=1S/C27H20N4O5/c1-30-16-29-15-24(30)27(32,20-8-6-17(14-28)7-9-20)25-12-19-10-21(31(33)34)13-23(26(19)36-25)18-4-3-5-22(11-18)35-2/h3-13,15-16,32H,1-2H3
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n/an/a 8.5n/an/an/an/an/an/a



Chugai Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FTase


Bioorg Med Chem Lett 19: 1753-7 (2009)

More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50479852
PNG
(CHEMBL473149)
Show SMILES Cc1cccc(c1)-c1cc(cc2cc(oc12)C(O)(c1cncn1C)c1ccc(cc1)C#N)[N+]([O-])=O
Show InChI InChI=1S/C27H20N4O4/c1-17-4-3-5-19(10-17)23-13-22(31(33)34)11-20-12-25(35-26(20)23)27(32,24-15-29-16-30(24)2)21-8-6-18(14-28)7-9-21/h3-13,15-16,32H,1-2H3
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n/an/a 11n/an/an/an/an/an/a



Chugai Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FTase


Bioorg Med Chem Lett 19: 1753-7 (2009)

More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50479840
PNG
(CHEMBL475148)
Show SMILES COc1cccc(c1)-c1cc(CN(C)C)cc2cc(oc12)C(O)(c1cncn1C)c1ccc(cc1)C#N
Show InChI InChI=1S/C30H28N4O3/c1-33(2)18-21-12-23-15-28(37-29(23)26(13-21)22-6-5-7-25(14-22)36-4)30(35,27-17-32-19-34(27)3)24-10-8-20(16-31)9-11-24/h5-15,17,19,35H,18H2,1-4H3
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n/an/a 11n/an/an/an/an/an/a



Chugai Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FTase


Bioorg Med Chem Lett 19: 1753-7 (2009)

More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50479841
PNG
(CHEMBL516185)
Show SMILES Cn1cncc1C(O)(c1cc2cc(cc(-c3ccccc3)c2o1)[N+]([O-])=O)c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C25H18N4O6/c1-27-15-26-14-22(27)25(30,18-7-9-19(10-8-18)28(31)32)23-12-17-11-20(29(33)34)13-21(24(17)35-23)16-5-3-2-4-6-16/h2-15,30H,1H3
PDB
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n/an/a 30n/an/an/an/an/an/a



Chugai Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FTase


Bioorg Med Chem Lett 19: 1753-7 (2009)

More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50479862
PNG
(CHEMBL489122)
Show SMILES Cn1cncc1[C@@](N)(c1cc2cc(cc(-c3ccccc3)c2o1)[N+]([O-])=O)c1ccc(cc1)C#N
Show InChI InChI=1S/C26H19N5O3/c1-30-16-29-15-23(30)26(28,20-9-7-17(14-27)8-10-20)24-12-19-11-21(31(32)33)13-22(25(19)34-24)18-5-3-2-4-6-18/h2-13,15-16H,28H2,1H3/t26-/m1/s1
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n/an/a 49n/an/an/an/an/an/a



Chugai Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FTase


Bioorg Med Chem Lett 19: 1753-7 (2009)

More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50479842
PNG
(CHEMBL461171)
Show SMILES Cn1cncc1C(O)(c1cc2cc(cc(-c3ccccc3)c2o1)[N+]([O-])=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C25H18ClN3O4/c1-28-15-27-14-22(28)25(30,18-7-9-19(26)10-8-18)23-12-17-11-20(29(31)32)13-21(24(17)33-23)16-5-3-2-4-6-16/h2-15,30H,1H3
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n/an/a 170n/an/an/an/an/an/a



Chugai Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FTase


Bioorg Med Chem Lett 19: 1753-7 (2009)

More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50479843
PNG
(CHEMBL472753)
Show SMILES COc1ccc(cc1)C(O)(c1cc2cc(cc(-c3ccccc3)c2o1)[N+]([O-])=O)c1cncn1C
Show InChI InChI=1S/C26H21N3O5/c1-28-16-27-15-23(28)26(30,19-8-10-21(33-2)11-9-19)24-13-18-12-20(29(31)32)14-22(25(18)34-24)17-6-4-3-5-7-17/h3-16,30H,1-2H3
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n/an/a 250n/an/an/an/an/an/a



Chugai Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FTase


Bioorg Med Chem Lett 19: 1753-7 (2009)

More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50479855
PNG
(CHEMBL517579)
Show SMILES Cn1cncc1C(O)(c1cc2cc(cc(-c3ccccc3)c2o1)[N+]([O-])=O)c1ccc(Br)cc1
Show InChI InChI=1S/C25H18BrN3O4/c1-28-15-27-14-22(28)25(30,18-7-9-19(26)10-8-18)23-12-17-11-20(29(31)32)13-21(24(17)33-23)16-5-3-2-4-6-16/h2-15,30H,1H3
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n/an/a 360n/an/an/an/an/an/a



Chugai Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FTase


Bioorg Med Chem Lett 19: 1753-7 (2009)

More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50479844
PNG
(CHEMBL518651)
Show SMILES Cn1cncc1C(O)(c1cc2cc(cc(-c3ccccc3)c2o1)[N+]([O-])=O)c1ccc(I)cc1
Show InChI InChI=1S/C25H18IN3O4/c1-28-15-27-14-22(28)25(30,18-7-9-19(26)10-8-18)23-12-17-11-20(29(31)32)13-21(24(17)33-23)16-5-3-2-4-6-16/h2-15,30H,1H3
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n/an/a 360n/an/an/an/an/an/a



Chugai Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FTase


Bioorg Med Chem Lett 19: 1753-7 (2009)

More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50479845
PNG
(CHEMBL515443)
Show SMILES Cn1cncc1C(O)(c1cc2cc(cc(-c3ccccc3)c2o1)[N+]([O-])=O)c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C26H19N3O6/c1-28-15-27-14-22(28)26(32,19-9-7-17(8-10-19)25(30)31)23-12-18-11-20(29(33)34)13-21(24(18)35-23)16-5-3-2-4-6-16/h2-15,32H,1H3,(H,30,31)
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n/an/a 850n/an/an/an/an/an/a



Chugai Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FTase


Bioorg Med Chem Lett 19: 1753-7 (2009)

More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Homo sapiens (Human))
BDBM50479846
PNG
(CHEMBL461812)
Show SMILES Cn1cncc1C(O)(c1cc2cc(cc(-c3ccccc3)c2o1)[N+]([O-])=O)c1ccc(cc1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C30H27N3O6/c1-29(2,3)39-28(34)20-10-12-22(13-11-20)30(35,25-17-31-18-32(25)4)26-15-21-14-23(33(36)37)16-24(27(21)38-26)19-8-6-5-7-9-19/h5-18,35H,1-4H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



Chugai Pharmaceutical Co. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human FTase


Bioorg Med Chem Lett 19: 1753-7 (2009)

More data for this
Ligand-Target Pair