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Found 89 hits from Cleave Biosciences, Inc.   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM163075
PNG
(US9062026, Table III, Compound 3)
Show SMILES COc1cccc2c(NCc3ccccc3)nc(Cc3ccccc3)nc12
Show InChI InChI=1S/C23H23N3O/c1-2-27-15-9-14-20-22(24-17-19-12-7-4-8-13-19)25-21(26-23(20)27)16-18-10-5-3-6-11-18/h3-15H,2,16-17H2,1H3,(H,24,25,26)
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Cleave Biosciences, Inc.

US Patent


Assay Description
The ATPase assay is performed according the following protocol: Purified enzyme (20 nM p97), substrate (20 uM ATP) and a dose titration of compounds ...


US Patent US9062026 (2015)


BindingDB Entry DOI: 10.7270/Q2765D32
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM163161
PNG
(US9062026, Table III, Compound 89)
Show SMILES COc1cccc2c(NCc3ccccc3)nc(nc12)-n1c(\C=C\S(C)(=O)=O)cc2ccccc12
Show InChI InChI=1S/C27H24N4O3S/c1-34-24-14-8-12-22-25(24)29-27(30-26(22)28-18-19-9-4-3-5-10-19)31-21(15-16-35(2,32)33)17-20-11-6-7-13-23(20)31/h3-17H,18H2,1-2H3,(H,28,29,30)/b16-15+
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Cleave Biosciences, Inc.

US Patent


Assay Description
The ATPase assay is performed according the following protocol: Purified enzyme (20 nM p97), substrate (20 uM ATP) and a dose titration of compounds ...


US Patent US9062026 (2015)


BindingDB Entry DOI: 10.7270/Q2765D32
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM163081
PNG
(US9062026, Table III, Compound 9)
Show SMILES COc1cccc2c(NCc3ccccc3)nc(nc12)-n1cnc2ccccc12
Show InChI InChI=1S/C23H19N5O/c1-29-20-13-7-10-17-21(20)26-23(28-15-25-18-11-5-6-12-19(18)28)27-22(17)24-14-16-8-3-2-4-9-16/h2-13,15H,14H2,1H3,(H,24,26,27)
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Cleave Biosciences, Inc.

US Patent


Assay Description
The ATPase assay is performed according the following protocol: Purified enzyme (20 nM p97), substrate (20 uM ATP) and a dose titration of compounds ...


US Patent US9062026 (2015)


BindingDB Entry DOI: 10.7270/Q2765D32
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM163082
PNG
(US9062026, Table III, Compound 10)
Show SMILES COc1nc2ccccc2n1-c1nc(NCc2ccccc2)c2cccc(OC)c2n1
Show InChI InChI=1S/C24H21N5O2/c1-30-20-14-8-11-17-21(20)27-23(28-22(17)25-15-16-9-4-3-5-10-16)29-19-13-7-6-12-18(19)26-24(29)31-2/h3-14H,15H2,1-2H3,(H,25,27,28)
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Cleave Biosciences, Inc.

US Patent


Assay Description
The ATPase assay is performed according the following protocol: Purified enzyme (20 nM p97), substrate (20 uM ATP) and a dose titration of compounds ...


US Patent US9062026 (2015)


BindingDB Entry DOI: 10.7270/Q2765D32
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM163085
PNG
(US9062026, Table III, Compound 13)
Show SMILES NCCOc1cccc2c(NCc3ccccc3)nc(nc12)-n1c(N)nc2ccccc12
Show InChI InChI=1S/C24H23N7O/c25-13-14-32-20-12-6-9-17-21(20)29-24(30-22(17)27-15-16-7-2-1-3-8-16)31-19-11-5-4-10-18(19)28-23(31)26/h1-12H,13-15,25H2,(H2,26,28)(H,27,29,30)
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Cleave Biosciences, Inc.

US Patent


Assay Description
The ATPase assay is performed according the following protocol: Purified enzyme (20 nM p97), substrate (20 uM ATP) and a dose titration of compounds ...


US Patent US9062026 (2015)


BindingDB Entry DOI: 10.7270/Q2765D32
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM163086
PNG
(US9062026, Table III, Compound 14)
Show SMILES COCCOc1cccc2c(NCc3ccccc3)nc(nc12)-n1c(N)nc2ccccc12
Show InChI InChI=1S/C25H24N6O2/c1-32-14-15-33-21-13-7-10-18-22(21)29-25(30-23(18)27-16-17-8-3-2-4-9-17)31-20-12-6-5-11-19(20)28-24(31)26/h2-13H,14-16H2,1H3,(H2,26,28)(H,27,29,30)
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Cleave Biosciences, Inc.

US Patent


Assay Description
The ATPase assay is performed according the following protocol: Purified enzyme (20 nM p97), substrate (20 uM ATP) and a dose titration of compounds ...


US Patent US9062026 (2015)


BindingDB Entry DOI: 10.7270/Q2765D32
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM163087
PNG
(US9062026, Table III, Compound 15)
Show SMILES NC(=O)COc1cccc2c(NCc3ccccc3)nc(nc12)-n1c(N)nc2ccccc12
Show InChI InChI=1S/C24H21N7O2/c25-20(32)14-33-19-12-6-9-16-21(19)29-24(30-22(16)27-13-15-7-2-1-3-8-15)31-18-11-5-4-10-17(18)28-23(31)26/h1-12H,13-14H2,(H2,25,32)(H2,26,28)(H,27,29,30)
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Cleave Biosciences, Inc.

US Patent


Assay Description
The ATPase assay is performed according the following protocol: Purified enzyme (20 nM p97), substrate (20 uM ATP) and a dose titration of compounds ...


US Patent US9062026 (2015)


BindingDB Entry DOI: 10.7270/Q2765D32
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM163088
PNG
(US9062026, Table III, Compound 16)
Show SMILES COCc1cccc2c(NCc3ccccc3)nc(nc12)-n1c(N)nc2ccccc12
Show InChI InChI=1S/C24H22N6O/c1-31-15-17-10-7-11-18-21(17)28-24(29-22(18)26-14-16-8-3-2-4-9-16)30-20-13-6-5-12-19(20)27-23(30)25/h2-13H,14-15H2,1H3,(H2,25,27)(H,26,28,29)
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Cleave Biosciences, Inc.

US Patent


Assay Description
The ATPase assay is performed according the following protocol: Purified enzyme (20 nM p97), substrate (20 uM ATP) and a dose titration of compounds ...


US Patent US9062026 (2015)


BindingDB Entry DOI: 10.7270/Q2765D32
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM163089
PNG
(US9062026, Table III, Compound 17)
Show SMILES Cc1cc2ccccc2n1-c1nc(NCc2ccccc2)c2cccc(CN)c2n1
Show InChI InChI=1S/C25H23N5/c1-17-14-19-10-5-6-13-22(19)30(17)25-28-23-20(15-26)11-7-12-21(23)24(29-25)27-16-18-8-3-2-4-9-18/h2-14H,15-16,26H2,1H3,(H,27,28,29)
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Cleave Biosciences, Inc.

US Patent


Assay Description
The ATPase assay is performed according the following protocol: Purified enzyme (20 nM p97), substrate (20 uM ATP) and a dose titration of compounds ...


US Patent US9062026 (2015)


BindingDB Entry DOI: 10.7270/Q2765D32
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM163092
PNG
(US9062026, Table III, Compound 20)
Show SMILES COc1nc2ccccc2n1-c1nc(NCc2ccccc2)c2ncsc2n1
Show InChI InChI=1S/C20H16N6OS/c1-27-20-23-14-9-5-6-10-15(14)26(20)19-24-17(16-18(25-19)28-12-22-16)21-11-13-7-3-2-4-8-13/h2-10,12H,11H2,1H3,(H,21,24,25)
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Cleave Biosciences, Inc.

US Patent


Assay Description
The ATPase assay is performed according the following protocol: Purified enzyme (20 nM p97), substrate (20 uM ATP) and a dose titration of compounds ...


US Patent US9062026 (2015)


BindingDB Entry DOI: 10.7270/Q2765D32
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM163094
PNG
(US9062026, Table III, Compound 22)
Show SMILES Nc1nc2ccccc2n1-c1nc2CCCc2c(NCc2ccccc2)n1
Show InChI InChI=1S/C21H20N6/c22-20-24-17-10-4-5-12-18(17)27(20)21-25-16-11-6-9-15(16)19(26-21)23-13-14-7-2-1-3-8-14/h1-5,7-8,10,12H,6,9,11,13H2,(H2,22,24)(H,23,25,26)
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Cleave Biosciences, Inc.

US Patent


Assay Description
The ATPase assay is performed according the following protocol: Purified enzyme (20 nM p97), substrate (20 uM ATP) and a dose titration of compounds ...


US Patent US9062026 (2015)


BindingDB Entry DOI: 10.7270/Q2765D32
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM163097
PNG
(US9062026, Table III, Compound 25)
Show SMILES CNc1nc2ccccc2n1-c1nc(NCc2ccccc2)c2cccc(OC)c2n1
Show InChI InChI=1S/C24H22N6O/c1-25-23-27-18-12-6-7-13-19(18)30(23)24-28-21-17(11-8-14-20(21)31-2)22(29-24)26-15-16-9-4-3-5-10-16/h3-14H,15H2,1-2H3,(H,25,27)(H,26,28,29)
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Cleave Biosciences, Inc.

US Patent


Assay Description
The ATPase assay is performed according the following protocol: Purified enzyme (20 nM p97), substrate (20 uM ATP) and a dose titration of compounds ...


US Patent US9062026 (2015)


BindingDB Entry DOI: 10.7270/Q2765D32
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM163098
PNG
(US9062026, Table III, Compound 26)
Show SMILES COc1cccc2c(NCc3ccccc3)nc(nc12)-n1c(nc2ccccc12)N(C)C
Show InChI InChI=1S/C25H24N6O/c1-30(2)25-27-19-13-7-8-14-20(19)31(25)24-28-22-18(12-9-15-21(22)32-3)23(29-24)26-16-17-10-5-4-6-11-17/h4-15H,16H2,1-3H3,(H,26,28,29)
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Cleave Biosciences, Inc.

US Patent


Assay Description
The ATPase assay is performed according the following protocol: Purified enzyme (20 nM p97), substrate (20 uM ATP) and a dose titration of compounds ...


US Patent US9062026 (2015)


BindingDB Entry DOI: 10.7270/Q2765D32
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM163100
PNG
(US9062026, Table III, Compound 28)
Show SMILES COc1cccc2c(NCc3ccccc3)nc(nc12)-c1c(N)[nH]c2ccccc12
Show InChI InChI=1S/C24H21N5O/c1-30-19-13-7-11-17-21(19)28-24(20-16-10-5-6-12-18(16)27-22(20)25)29-23(17)26-14-15-8-3-2-4-9-15/h2-13,27H,14,25H2,1H3,(H,26,28,29)
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Cleave Biosciences, Inc.

US Patent


Assay Description
The ATPase assay is performed according the following protocol: Purified enzyme (20 nM p97), substrate (20 uM ATP) and a dose titration of compounds ...


US Patent US9062026 (2015)


BindingDB Entry DOI: 10.7270/Q2765D32
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM163103
PNG
(US9062026, Table III, Compound 31)
Show SMILES COc1cccc2c(NCc3ccccc3)nc(nc12)N1C(=O)Cc2ccccc12
Show InChI InChI=1S/C24H20N4O2/c1-30-20-13-7-11-18-22(20)26-24(27-23(18)25-15-16-8-3-2-4-9-16)28-19-12-6-5-10-17(19)14-21(28)29/h2-13H,14-15H2,1H3,(H,25,26,27)
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Cleave Biosciences, Inc.

US Patent


Assay Description
The ATPase assay is performed according the following protocol: Purified enzyme (20 nM p97), substrate (20 uM ATP) and a dose titration of compounds ...


US Patent US9062026 (2015)


BindingDB Entry DOI: 10.7270/Q2765D32
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM163106
PNG
(US9062026, Table III, Compound 34)
Show SMILES COc1cccc2c(NCc3ccccc3)nc(nc12)-n1c2ccccc2[nH]c1=O
Show InChI InChI=1S/C23H19N5O2/c1-30-19-13-7-10-16-20(19)26-22(27-21(16)24-14-15-8-3-2-4-9-15)28-18-12-6-5-11-17(18)25-23(28)29/h2-13H,14H2,1H3,(H,25,29)(H,24,26,27)
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Cleave Biosciences, Inc.

US Patent


Assay Description
The ATPase assay is performed according the following protocol: Purified enzyme (20 nM p97), substrate (20 uM ATP) and a dose titration of compounds ...


US Patent US9062026 (2015)


BindingDB Entry DOI: 10.7270/Q2765D32
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM163108
PNG
(US9062026, Table III, Compound 36)
Show SMILES COc1cccc2c(NCc3ccccc3)nc(nc12)-n1c(CN)nc2sccc12
Show InChI InChI=1S/C22H20N6OS/c1-29-17-9-5-8-15-19(17)26-22(27-20(15)24-13-14-6-3-2-4-7-14)28-16-10-11-30-21(16)25-18(28)12-23/h2-11H,12-13,23H2,1H3,(H,24,26,27)
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Cleave Biosciences, Inc.

US Patent


Assay Description
The ATPase assay is performed according the following protocol: Purified enzyme (20 nM p97), substrate (20 uM ATP) and a dose titration of compounds ...


US Patent US9062026 (2015)


BindingDB Entry DOI: 10.7270/Q2765D32
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM163109
PNG
(US9062026, Table III, Compound 37)
Show SMILES COc1cccc2c(NCc3ccccc3)nc(nc12)-n1c(C)cc2ccccc12
Show InChI InChI=1S/C25H22N4O/c1-17-15-19-11-6-7-13-21(19)29(17)25-27-23-20(12-8-14-22(23)30-2)24(28-25)26-16-18-9-4-3-5-10-18/h3-15H,16H2,1-2H3,(H,26,27,28)
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Cleave Biosciences, Inc.

US Patent


Assay Description
The ATPase assay is performed according the following protocol: Purified enzyme (20 nM p97), substrate (20 uM ATP) and a dose titration of compounds ...


US Patent US9062026 (2015)


BindingDB Entry DOI: 10.7270/Q2765D32
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM163112
PNG
(US9062026, Table III, Compound 40)
Show SMILES COc1cccc2c(NCc3ccccc3)nc(nc12)C1CNc2ccccc12
Show InChI InChI=1S/C24H22N4O/c1-29-21-13-7-11-18-22(21)27-24(19-15-25-20-12-6-5-10-17(19)20)28-23(18)26-14-16-8-3-2-4-9-16/h2-13,19,25H,14-15H2,1H3,(H,26,27,28)
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Cleave Biosciences, Inc.

US Patent


Assay Description
The ATPase assay is performed according the following protocol: Purified enzyme (20 nM p97), substrate (20 uM ATP) and a dose titration of compounds ...


US Patent US9062026 (2015)


BindingDB Entry DOI: 10.7270/Q2765D32
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM163113
PNG
(US9062026, Table III, Compound 41)
Show SMILES COC1=Nc2ccccc2C1c1nc(NCc2ccc(F)cc2)c2cccc(OC)c2n1
Show InChI InChI=1S/C25H21FN4O2/c1-31-20-9-5-7-18-22(20)29-24(21-17-6-3-4-8-19(17)28-25(21)32-2)30-23(18)27-14-15-10-12-16(26)13-11-15/h3-13,21H,14H2,1-2H3,(H,27,29,30)
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Cleave Biosciences, Inc.

US Patent


Assay Description
The ATPase assay is performed according the following protocol: Purified enzyme (20 nM p97), substrate (20 uM ATP) and a dose titration of compounds ...


US Patent US9062026 (2015)


BindingDB Entry DOI: 10.7270/Q2765D32
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM163114
PNG
(US9062026, Table III, Compound 42)
Show SMILES COc1nc2ccccc2n1-c1nc2CCNCc2c(NCc2ccccc2)n1
Show InChI InChI=1S/C22H22N6O/c1-29-22-26-18-9-5-6-10-19(18)28(22)21-25-17-11-12-23-14-16(17)20(27-21)24-13-15-7-3-2-4-8-15/h2-10,23H,11-14H2,1H3,(H,24,25,27)
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Cleave Biosciences, Inc.

US Patent


Assay Description
The ATPase assay is performed according the following protocol: Purified enzyme (20 nM p97), substrate (20 uM ATP) and a dose titration of compounds ...


US Patent US9062026 (2015)


BindingDB Entry DOI: 10.7270/Q2765D32
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM163115
PNG
(US9062026, Table III, Compound 43)
Show SMILES Cc1cc2ccccc2n1-c1nc2CCNCc2c(NCc2ccccc2)n1
Show InChI InChI=1S/C23H23N5/c1-16-13-18-9-5-6-10-21(18)28(16)23-26-20-11-12-24-15-19(20)22(27-23)25-14-17-7-3-2-4-8-17/h2-10,13,24H,11-12,14-15H2,1H3,(H,25,26,27)
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Cleave Biosciences, Inc.

US Patent


Assay Description
The ATPase assay is performed according the following protocol: Purified enzyme (20 nM p97), substrate (20 uM ATP) and a dose titration of compounds ...


US Patent US9062026 (2015)


BindingDB Entry DOI: 10.7270/Q2765D32
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM163116
PNG
(US9062026, Table III, Compound 44)
Show SMILES Cc1cc2ccccc2n1-c1nc2CNCCc2c(NCc2ccccc2)n1
Show InChI InChI=1S/C23H23N5/c1-16-13-18-9-5-6-10-21(18)28(16)23-26-20-15-24-12-11-19(20)22(27-23)25-14-17-7-3-2-4-8-17/h2-10,13,24H,11-12,14-15H2,1H3,(H,25,26,27)
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Cleave Biosciences, Inc.

US Patent


Assay Description
The ATPase assay is performed according the following protocol: Purified enzyme (20 nM p97), substrate (20 uM ATP) and a dose titration of compounds ...


US Patent US9062026 (2015)


BindingDB Entry DOI: 10.7270/Q2765D32
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM163118
PNG
(US9062026, Table III, Compound 46)
Show SMILES Cc1cc2ccccc2n1-c1nc2CNCc2c(NCc2ccccc2)n1
Show InChI InChI=1S/C22H21N5/c1-15-11-17-9-5-6-10-20(17)27(15)22-25-19-14-23-13-18(19)21(26-22)24-12-16-7-3-2-4-8-16/h2-11,23H,12-14H2,1H3,(H,24,25,26)
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Cleave Biosciences, Inc.

US Patent


Assay Description
The ATPase assay is performed according the following protocol: Purified enzyme (20 nM p97), substrate (20 uM ATP) and a dose titration of compounds ...


US Patent US9062026 (2015)


BindingDB Entry DOI: 10.7270/Q2765D32
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM163120
PNG
(US9062026, Table III, Compound 48)
Show SMILES CCc1cc2ccccc2n1-c1nc(NCc2ccccc2)c2cccc(OC)c2n1
Show InChI InChI=1S/C26H24N3O.Na/c1-3-23-16-21-12-7-8-15-25(21)29(23)19-28-26(22-13-9-14-24(17-22)30-2)27-18-20-10-5-4-6-11-20;/h4-16,27H,3,18H2,1-2H3;/b26-22-,28-19?;
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Cleave Biosciences, Inc.

US Patent


Assay Description
The ATPase assay is performed according the following protocol: Purified enzyme (20 nM p97), substrate (20 uM ATP) and a dose titration of compounds ...


US Patent US9062026 (2015)


BindingDB Entry DOI: 10.7270/Q2765D32
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM163121
PNG
(US9062026, Table III, Compound 49)
Show SMILES COc1cc2ccccc2n1-c1nc(NCc2ccccc2)c2cccc(OC)c2n1
Show InChI InChI=1S/C25H22N4O2/c1-30-21-14-8-12-19-23(21)27-25(28-24(19)26-16-17-9-4-3-5-10-17)29-20-13-7-6-11-18(20)15-22(29)31-2/h3-15H,16H2,1-2H3,(H,26,27,28)
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Cleave Biosciences, Inc.

US Patent


Assay Description
The ATPase assay is performed according the following protocol: Purified enzyme (20 nM p97), substrate (20 uM ATP) and a dose titration of compounds ...


US Patent US9062026 (2015)


BindingDB Entry DOI: 10.7270/Q2765D32
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM163122
PNG
(US9062026, Table III, Compound 50)
Show SMILES COc1cccc2c(NCc3ccccc3)nc(nc12)-n1c(CN)cc2ccccc12
Show InChI InChI=1S/C25H23N5O/c1-31-22-13-7-11-20-23(22)28-25(29-24(20)27-16-17-8-3-2-4-9-17)30-19(15-26)14-18-10-5-6-12-21(18)30/h2-14H,15-16,26H2,1H3,(H,27,28,29)
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Cleave Biosciences, Inc.

US Patent


Assay Description
The ATPase assay is performed according the following protocol: Purified enzyme (20 nM p97), substrate (20 uM ATP) and a dose titration of compounds ...


US Patent US9062026 (2015)


BindingDB Entry DOI: 10.7270/Q2765D32
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM163123
PNG
(US9062026, Table III, Compound 51)
Show SMILES COc1cccc2c(NCc3ccccc3)nc(nc12)-n1ccc2ccccc12
Show InChI InChI=1S/C24H20N4O/c1-29-21-13-7-11-19-22(21)26-24(28-15-14-18-10-5-6-12-20(18)28)27-23(19)25-16-17-8-3-2-4-9-17/h2-15H,16H2,1H3,(H,25,26,27)
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Cleave Biosciences, Inc.

US Patent


Assay Description
The ATPase assay is performed according the following protocol: Purified enzyme (20 nM p97), substrate (20 uM ATP) and a dose titration of compounds ...


US Patent US9062026 (2015)


BindingDB Entry DOI: 10.7270/Q2765D32
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM163125
PNG
(US9062026, Table III, Compound 53)
Show SMILES COc1cccc2c(NCc3ccccc3)nc(nc12)-c1c(C)oc2ccccc12
Show InChI InChI=1S/C25H21N3O2/c1-16-22(18-11-6-7-13-20(18)30-16)25-27-23-19(12-8-14-21(23)29-2)24(28-25)26-15-17-9-4-3-5-10-17/h3-14H,15H2,1-2H3,(H,26,27,28)
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Cleave Biosciences, Inc.

US Patent


Assay Description
The ATPase assay is performed according the following protocol: Purified enzyme (20 nM p97), substrate (20 uM ATP) and a dose titration of compounds ...


US Patent US9062026 (2015)


BindingDB Entry DOI: 10.7270/Q2765D32
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM163126
PNG
(US9062026, Table III, Compound 54)
Show SMILES Cc1cc2ccccc2n1-c1nc(NCc2ccccc2)c2cccc(C(N)=O)c2n1
Show InChI InChI=1S/C25H21N5O/c1-16-14-18-10-5-6-13-21(18)30(16)25-28-22-19(23(26)31)11-7-12-20(22)24(29-25)27-15-17-8-3-2-4-9-17/h2-14H,15H2,1H3,(H2,26,31)(H,27,28,29)
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Cleave Biosciences, Inc.

US Patent


Assay Description
The ATPase assay is performed according the following protocol: Purified enzyme (20 nM p97), substrate (20 uM ATP) and a dose titration of compounds ...


US Patent US9062026 (2015)


BindingDB Entry DOI: 10.7270/Q2765D32
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM163127
PNG
(US9062026, Table III, Compound 55)
Show SMILES Cc1cc2ccccc2n1-c1nc2COCc2c(NCc2ccccc2)n1
Show InChI InChI=1S/C22H20N4O/c1-15-11-17-9-5-6-10-20(17)26(15)22-24-19-14-27-13-18(19)21(25-22)23-12-16-7-3-2-4-8-16/h2-11H,12-14H2,1H3,(H,23,24,25)
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Cleave Biosciences, Inc.

US Patent


Assay Description
The ATPase assay is performed according the following protocol: Purified enzyme (20 nM p97), substrate (20 uM ATP) and a dose titration of compounds ...


US Patent US9062026 (2015)


BindingDB Entry DOI: 10.7270/Q2765D32
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM163128
PNG
(US9062026, Table III, Compound 56)
Show SMILES Cc1cc2ccccc2n1-c1nc(NCc2ccccc2)c2cccc(C#N)c2n1
Show InChI InChI=1S/C25H19N5/c1-17-14-19-10-5-6-13-22(19)30(17)25-28-23-20(15-26)11-7-12-21(23)24(29-25)27-16-18-8-3-2-4-9-18/h2-14H,16H2,1H3,(H,27,28,29)
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Cleave Biosciences, Inc.

US Patent


Assay Description
The ATPase assay is performed according the following protocol: Purified enzyme (20 nM p97), substrate (20 uM ATP) and a dose titration of compounds ...


US Patent US9062026 (2015)


BindingDB Entry DOI: 10.7270/Q2765D32
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM163129
PNG
(US9062026, Table III, Compound 57)
Show SMILES Cc1cc2ccccc2n1-c1nc2CN(CCc2c(NCc2ccccc2)n1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C28H31N5O2/c1-19-16-21-12-8-9-13-24(21)33(19)26-30-23-18-32(27(34)35-28(2,3)4)15-14-22(23)25(31-26)29-17-20-10-6-5-7-11-20/h5-13,16H,14-15,17-18H2,1-4H3,(H,29,30,31)
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Cleave Biosciences, Inc.

US Patent


Assay Description
The ATPase assay is performed according the following protocol: Purified enzyme (20 nM p97), substrate (20 uM ATP) and a dose titration of compounds ...


US Patent US9062026 (2015)


BindingDB Entry DOI: 10.7270/Q2765D32
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM163130
PNG
(US9062026, Table III, Compound 58)
Show SMILES CC(=O)N1Cc2nc(nc(NCc3ccccc3)c2C1)-n1c(C)cc2ccccc12
Show InChI InChI=1S/C24H23N5O/c1-16-12-19-10-6-7-11-22(19)29(16)24-26-21-15-28(17(2)30)14-20(21)23(27-24)25-13-18-8-4-3-5-9-18/h3-12H,13-15H2,1-2H3,(H,25,26,27)
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Cleave Biosciences, Inc.

US Patent


Assay Description
The ATPase assay is performed according the following protocol: Purified enzyme (20 nM p97), substrate (20 uM ATP) and a dose titration of compounds ...


US Patent US9062026 (2015)


BindingDB Entry DOI: 10.7270/Q2765D32
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM163131
PNG
(US9062026, Table III, Compound 59)
Show SMILES CC(=O)N1CCc2nc(nc(NCc3ccccc3)c2C1)-n1c(C)cc2ccccc12
Show InChI InChI=1S/C25H25N5O/c1-17-14-20-10-6-7-11-23(20)30(17)25-27-22-12-13-29(18(2)31)16-21(22)24(28-25)26-15-19-8-4-3-5-9-19/h3-11,14H,12-13,15-16H2,1-2H3,(H,26,27,28)
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Cleave Biosciences, Inc.

US Patent


Assay Description
The ATPase assay is performed according the following protocol: Purified enzyme (20 nM p97), substrate (20 uM ATP) and a dose titration of compounds ...


US Patent US9062026 (2015)


BindingDB Entry DOI: 10.7270/Q2765D32
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM163132
PNG
(US9062026, Table III, Compound 60)
Show SMILES CC(=O)N1CCc2c(C1)nc(nc2NCc1ccccc1)C1C(C)=Cc2ccccc12
Show InChI InChI=1S/C26H26N4O/c1-17-14-20-10-6-7-11-21(20)24(17)26-28-23-16-30(18(2)31)13-12-22(23)25(29-26)27-15-19-8-4-3-5-9-19/h3-11,14,24H,12-13,15-16H2,1-2H3,(H,27,28,29)
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Cleave Biosciences, Inc.

US Patent


Assay Description
The ATPase assay is performed according the following protocol: Purified enzyme (20 nM p97), substrate (20 uM ATP) and a dose titration of compounds ...


US Patent US9062026 (2015)


BindingDB Entry DOI: 10.7270/Q2765D32
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM163133
PNG
(US9062026, Table III, Compound 61)
Show SMILES COc1cc2ccccc2n1-c1nc(NCc2ccccc2)c2CCN(C(=O)OC(C)(C)C)C(=O)c2n1
Show InChI InChI=1S/C28H29N5O4/c1-28(2,3)37-27(35)32-15-14-20-23(25(32)34)30-26(31-24(20)29-17-18-10-6-5-7-11-18)33-21-13-9-8-12-19(21)16-22(33)36-4/h5-13,16H,14-15,17H2,1-4H3,(H,29,30,31)
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Cleave Biosciences, Inc.

US Patent


Assay Description
The ATPase assay is performed according the following protocol: Purified enzyme (20 nM p97), substrate (20 uM ATP) and a dose titration of compounds ...


US Patent US9062026 (2015)


BindingDB Entry DOI: 10.7270/Q2765D32
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM163134
PNG
(US9062026, Table III, Compound 62)
Show SMILES Cc1cc2ccccc2n1-c1nc2CCCCc2c(NCc2ccccc2)n1
Show InChI InChI=1S/C24H24N4/c1-17-15-19-11-5-8-14-22(19)28(17)24-26-21-13-7-6-12-20(21)23(27-24)25-16-18-9-3-2-4-10-18/h2-5,8-11,14-15H,6-7,12-13,16H2,1H3,(H,25,26,27)
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Cleave Biosciences, Inc.

US Patent


Assay Description
The ATPase assay is performed according the following protocol: Purified enzyme (20 nM p97), substrate (20 uM ATP) and a dose titration of compounds ...


US Patent US9062026 (2015)


BindingDB Entry DOI: 10.7270/Q2765D32
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM163136
PNG
(US9062026, Table III, Compound 64 | US9062026, Tab...)
Show SMILES NCc1cc2ccccc2n1-c1nc2CCCCc2c(NCc2ccccc2)n1
Show InChI InChI=1S/C24H25N5/c25-15-19-14-18-10-4-7-13-22(18)29(19)24-27-21-12-6-5-11-20(21)23(28-24)26-16-17-8-2-1-3-9-17/h1-4,7-10,13-14H,5-6,11-12,15-16,25H2,(H,26,27,28)
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Cleave Biosciences, Inc.

US Patent


Assay Description
The ATPase assay is performed according the following protocol: Purified enzyme (20 nM p97), substrate (20 uM ATP) and a dose titration of compounds ...


US Patent US9062026 (2015)


BindingDB Entry DOI: 10.7270/Q2765D32
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM163137
PNG
(US9062026, Table III, Compound 65)
Show SMILES CC(N)c1cc2ccccc2n1-c1nc2CCCCc2c(NCc2ccccc2)n1
Show InChI InChI=1S/C25H27N5/c1-17(26)23-15-19-11-5-8-14-22(19)30(23)25-28-21-13-7-6-12-20(21)24(29-25)27-16-18-9-3-2-4-10-18/h2-5,8-11,14-15,17H,6-7,12-13,16,26H2,1H3,(H,27,28,29)
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Cleave Biosciences, Inc.

US Patent


Assay Description
The ATPase assay is performed according the following protocol: Purified enzyme (20 nM p97), substrate (20 uM ATP) and a dose titration of compounds ...


US Patent US9062026 (2015)


BindingDB Entry DOI: 10.7270/Q2765D32
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM163138
PNG
(US9062026, Table III, Compound 66)
Show SMILES COCCOc1cccc2c(NCc3ccccc3)nc(nc12)C1C(ON)=Nc2ccccc12
Show InChI InChI=1S/C26H25N5O3/c1-32-14-15-33-21-13-7-11-19-23(21)30-25(31-24(19)28-16-17-8-3-2-4-9-17)22-18-10-5-6-12-20(18)29-26(22)34-27/h2-13,22H,14-16,27H2,1H3,(H,28,30,31)
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Cleave Biosciences, Inc.

US Patent


Assay Description
The ATPase assay is performed according the following protocol: Purified enzyme (20 nM p97), substrate (20 uM ATP) and a dose titration of compounds ...


US Patent US9062026 (2015)


BindingDB Entry DOI: 10.7270/Q2765D32
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM163139
PNG
(US9062026, Table III, Compound 67)
Show SMILES COCCOc1cccc2c(NCc3ccccc3)nc(nc12)-n1c(OC)nc2ccccc12
Show InChI InChI=1S/C26H25N5O3/c1-32-15-16-34-22-14-8-11-19-23(22)29-25(30-24(19)27-17-18-9-4-3-5-10-18)31-21-13-7-6-12-20(21)28-26(31)33-2/h3-14H,15-17H2,1-2H3,(H,27,29,30)
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Cleave Biosciences, Inc.

US Patent


Assay Description
The ATPase assay is performed according the following protocol: Purified enzyme (20 nM p97), substrate (20 uM ATP) and a dose titration of compounds ...


US Patent US9062026 (2015)


BindingDB Entry DOI: 10.7270/Q2765D32
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM163140
PNG
(US9062026, Table III, Compound 68)
Show SMILES COc1cccc2c(NCc3ccccc3)nc(nc12)-n1c(CNC(C)=O)cc2ccccc12
Show InChI InChI=1S/C27H25N5O2/c1-18(33)28-17-21-15-20-11-6-7-13-23(20)32(21)27-30-25-22(12-8-14-24(25)34-2)26(31-27)29-16-19-9-4-3-5-10-19/h3-15H,16-17H2,1-2H3,(H,28,33)(H,29,30,31)
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Cleave Biosciences, Inc.

US Patent


Assay Description
The ATPase assay is performed according the following protocol: Purified enzyme (20 nM p97), substrate (20 uM ATP) and a dose titration of compounds ...


US Patent US9062026 (2015)


BindingDB Entry DOI: 10.7270/Q2765D32
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM163141
PNG
(US9062026, Table III, Compound 69)
Show SMILES COc1cccc2c(NCc3ccccc3)nc(nc12)-n1c(CNC(=O)C=C)cc2ccccc12
Show InChI InChI=1S/C28H25N5O2/c1-3-25(34)29-18-21-16-20-12-7-8-14-23(20)33(21)28-31-26-22(13-9-15-24(26)35-2)27(32-28)30-17-19-10-5-4-6-11-19/h3-16H,1,17-18H2,2H3,(H,29,34)(H,30,31,32)
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Cleave Biosciences, Inc.

US Patent


Assay Description
The ATPase assay is performed according the following protocol: Purified enzyme (20 nM p97), substrate (20 uM ATP) and a dose titration of compounds ...


US Patent US9062026 (2015)


BindingDB Entry DOI: 10.7270/Q2765D32
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM163142
PNG
(US9062026, Table III, Compound 70)
Show SMILES CCc1nc2ccccc2n1-c1nc(NCc2ccccc2)c2cccc(OC)c2n1
Show InChI InChI=1S/C25H23N5O/c1-3-22-27-19-13-7-8-14-20(19)30(22)25-28-23-18(12-9-15-21(23)31-2)24(29-25)26-16-17-10-5-4-6-11-17/h4-15H,3,16H2,1-2H3,(H,26,28,29)
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Cleave Biosciences, Inc.

US Patent


Assay Description
The ATPase assay is performed according the following protocol: Purified enzyme (20 nM p97), substrate (20 uM ATP) and a dose titration of compounds ...


US Patent US9062026 (2015)


BindingDB Entry DOI: 10.7270/Q2765D32
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM163143
PNG
(US9062026, Table III, Compound 71)
Show SMILES COc1cc2ccccc2n1-c1nc2CCCCc2c(NCc2ccccc2)n1
Show InChI InChI=1S/C24H24N4O/c1-29-22-15-18-11-5-8-14-21(18)28(22)24-26-20-13-7-6-12-19(20)23(27-24)25-16-17-9-3-2-4-10-17/h2-5,8-11,14-15H,6-7,12-13,16H2,1H3,(H,25,26,27)
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Cleave Biosciences, Inc.

US Patent


Assay Description
The ATPase assay is performed according the following protocol: Purified enzyme (20 nM p97), substrate (20 uM ATP) and a dose titration of compounds ...


US Patent US9062026 (2015)


BindingDB Entry DOI: 10.7270/Q2765D32
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM163144
PNG
(US9062026, Table III, Compound 72)
Show SMILES OCc1cc2ccccc2n1-c1nc2CCCCc2c(NCc2ccccc2)n1
Show InChI InChI=1S/C24H24N4O/c29-16-19-14-18-10-4-7-13-22(18)28(19)24-26-21-12-6-5-11-20(21)23(27-24)25-15-17-8-2-1-3-9-17/h1-4,7-10,13-14,29H,5-6,11-12,15-16H2,(H,25,26,27)
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Cleave Biosciences, Inc.

US Patent


Assay Description
The ATPase assay is performed according the following protocol: Purified enzyme (20 nM p97), substrate (20 uM ATP) and a dose titration of compounds ...


US Patent US9062026 (2015)


BindingDB Entry DOI: 10.7270/Q2765D32
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM163145
PNG
(US9062026, Table III, Compound 73)
Show SMILES COCc1cc2ccccc2n1-c1nc2CCCCc2c(NCc2ccccc2)n1
Show InChI InChI=1S/C25H26N4O/c1-30-17-20-15-19-11-5-8-14-23(19)29(20)25-27-22-13-7-6-12-21(22)24(28-25)26-16-18-9-3-2-4-10-18/h2-5,8-11,14-15H,6-7,12-13,16-17H2,1H3,(H,26,27,28)
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Cleave Biosciences, Inc.

US Patent


Assay Description
The ATPase assay is performed according the following protocol: Purified enzyme (20 nM p97), substrate (20 uM ATP) and a dose titration of compounds ...


US Patent US9062026 (2015)


BindingDB Entry DOI: 10.7270/Q2765D32
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM163146
PNG
(US9062026, Table III, Compound 74)
Show SMILES CN(C)Cc1cc2ccccc2n1-c1nc2CCCCc2c(NCc2ccccc2)n1
Show InChI InChI=1S/C26H29N5/c1-30(2)18-21-16-20-12-6-9-15-24(20)31(21)26-28-23-14-8-7-13-22(23)25(29-26)27-17-19-10-4-3-5-11-19/h3-6,9-12,15-16H,7-8,13-14,17-18H2,1-2H3,(H,27,28,29)
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Cleave Biosciences, Inc.

US Patent


Assay Description
The ATPase assay is performed according the following protocol: Purified enzyme (20 nM p97), substrate (20 uM ATP) and a dose titration of compounds ...


US Patent US9062026 (2015)


BindingDB Entry DOI: 10.7270/Q2765D32
More data for this
Ligand-Target Pair
Valosin containing protein, p97 subunit


(Homo sapiens (Human))
BDBM163147
PNG
(US9062026, Table III, Compound 75)
Show SMILES CC(=O)NCc1cc2ccccc2n1-c1nc2CCCCc2c(NCc2ccccc2)n1
Show InChI InChI=1S/C26H27N5O/c1-18(32)27-17-21-15-20-11-5-8-14-24(20)31(21)26-29-23-13-7-6-12-22(23)25(30-26)28-16-19-9-3-2-4-10-19/h2-5,8-11,14-15H,6-7,12-13,16-17H2,1H3,(H,27,32)(H,28,29,30)
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Cleave Biosciences, Inc.

US Patent


Assay Description
The ATPase assay is performed according the following protocol: Purified enzyme (20 nM p97), substrate (20 uM ATP) and a dose titration of compounds ...


US Patent US9062026 (2015)


BindingDB Entry DOI: 10.7270/Q2765D32
More data for this
Ligand-Target Pair
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