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Compile Data Set for Download or QSAR

Found 175 hits from Confluence Life Sciences, Inc.   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM70579
PNG
(US9695200, 1)
Show SMILES C=CC(=O)NC1CN(C1)c1cnc2[nH]cc(-c3ccccc3)c2c1
Show InChI InChI=1S/C19H18N4O/c1-2-18(24)22-14-11-23(12-14)15-8-16-17(10-21-19(16)20-9-15)13-6-4-3-5-7-13/h2-10,14H,1,11-12H2,(H,20,21)(H,22,24)
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n/an/a<1.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)


Article DOI: 10.1021/jm950874+
BindingDB Entry DOI: 10.7270/Q20G3H9T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM77948
PNG
(US9695200, 2)
Show SMILES COc1cc(ccn1)-c1c[nH]c2ncc(cc12)N1CC(C1)NC(=O)C=C
Show InChI InChI=1S/C19H19N5O2/c1-3-17(25)23-13-10-24(11-13)14-7-15-16(9-22-19(15)21-8-14)12-4-5-20-18(6-12)26-2/h3-9,13H,1,10-11H2,2H3,(H,21,22)(H,23,25)
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n/an/a<1.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)


Article DOI: 10.1021/jm950874+
BindingDB Entry DOI: 10.7270/Q20G3H9T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM77949
PNG
(US9695200, 3)
Show SMILES COc1ccc(cn1)-c1c[nH]c2ncc(cc12)N1CC(C1)NC(=O)C=C
Show InChI InChI=1S/C19H19N5O2/c1-3-17(25)23-13-10-24(11-13)14-6-15-16(9-22-19(15)21-8-14)12-4-5-18(26-2)20-7-12/h3-9,13H,1,10-11H2,2H3,(H,21,22)(H,23,25)
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n/an/a<1.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)


Article DOI: 10.1021/jm950874+
BindingDB Entry DOI: 10.7270/Q20G3H9T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM77950
PNG
(US9695200, 4)
Show SMILES Cc1cc(ccn1)-c1c[nH]c2ncc(cc12)N1CC(C1)NC(=O)C=C
Show InChI InChI=1S/C19H19N5O/c1-3-18(25)23-14-10-24(11-14)15-7-16-17(9-22-19(16)21-8-15)13-4-5-20-12(2)6-13/h3-9,14H,1,10-11H2,2H3,(H,21,22)(H,23,25)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)


Article DOI: 10.1021/jm950874+
BindingDB Entry DOI: 10.7270/Q20G3H9T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM77951
PNG
(US9695200, 5)
Show SMILES C=CC(=O)NC1CN(C1)c1cnc2[nH]cc(-c3ccnc(c3)C#N)c2c1
Show InChI InChI=1S/C19H16N6O/c1-2-18(26)24-14-10-25(11-14)15-6-16-17(9-23-19(16)22-8-15)12-3-4-21-13(5-12)7-20/h2-6,8-9,14H,1,10-11H2,(H,22,23)(H,24,26)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)


Article DOI: 10.1021/jm950874+
BindingDB Entry DOI: 10.7270/Q20G3H9T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM81141
PNG
(US9695200, 6)
Show SMILES COc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C22H18N4O2/c1-3-20(27)26-17-6-4-5-14(9-17)16-10-18-19(13-25-22(18)24-12-16)15-7-8-23-21(11-15)28-2/h3-13H,1H2,2H3,(H,24,25)(H,26,27)
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n/an/a<1.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)


Article DOI: 10.1021/jm950874+
BindingDB Entry DOI: 10.7270/Q20G3H9T
More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM81141
PNG
(US9695200, 6)
Show SMILES COc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C22H18N4O2/c1-3-20(27)26-17-6-4-5-14(9-17)16-10-18-19(13-25-22(18)24-12-16)15-7-8-23-21(11-15)28-2/h3-13H,1H2,2H3,(H,24,25)(H,26,27)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)


Article DOI: 10.1021/jm950874+
BindingDB Entry DOI: 10.7270/Q20G3H9T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM81170
PNG
(US9695200, 7)
Show SMILES C=CC(=O)Nc1cccc(c1)-c1cnc2[nH]cc(-c3ccncc3)c2c1
Show InChI InChI=1S/C21H16N4O/c1-2-20(26)25-17-5-3-4-15(10-17)16-11-18-19(13-24-21(18)23-12-16)14-6-8-22-9-7-14/h2-13H,1H2,(H,23,24)(H,25,26)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)


Article DOI: 10.1021/jm950874+
BindingDB Entry DOI: 10.7270/Q20G3H9T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM81238
PNG
(US9695200, 8)
Show SMILES NC(=O)C(=C\c1cccc(c1)-c1cnc2[nH]cc(-c3ccncc3)c2c1)\C#N
Show InChI InChI=1S/C22H15N5O/c23-11-17(21(24)28)9-14-2-1-3-16(8-14)18-10-19-20(13-27-22(19)26-12-18)15-4-6-25-7-5-15/h1-10,12-13H,(H2,24,28)(H,26,27)/b17-9+
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)


Article DOI: 10.1021/jm950874+
BindingDB Entry DOI: 10.7270/Q20G3H9T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM81266
PNG
(US9695200, 9)
Show SMILES COc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cccc(\C=C(/C#N)C(N)=O)c1
Show InChI InChI=1S/C23H17N5O2/c1-30-21-10-16(5-6-26-21)20-13-28-23-19(20)9-18(12-27-23)15-4-2-3-14(7-15)8-17(11-24)22(25)29/h2-10,12-13H,1H3,(H2,25,29)(H,27,28)/b17-8+
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n/an/a<1.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)


Article DOI: 10.1021/jm950874+
BindingDB Entry DOI: 10.7270/Q20G3H9T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM86369
PNG
(US9695200, 10)
Show SMILES C=CC(=O)NC1CN(C1)c1cnc2[nH]cc(-c3ccncc3)c2c1
Show InChI InChI=1S/C18H17N5O/c1-2-17(24)22-13-10-23(11-13)14-7-15-16(9-21-18(15)20-8-14)12-3-5-19-6-4-12/h2-9,13H,1,10-11H2,(H,20,21)(H,22,24)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)


Article DOI: 10.1021/jm950874+
BindingDB Entry DOI: 10.7270/Q20G3H9T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM87738
PNG
(US9695200, 11)
Show SMILES COc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cc(NC(=O)C=C)cc(c1)C(F)(F)F
Show InChI InChI=1S/C23H17F3N4O2/c1-3-20(31)30-17-7-14(6-16(10-17)23(24,25)26)15-8-18-19(12-29-22(18)28-11-15)13-4-5-27-21(9-13)32-2/h3-12H,1H2,2H3,(H,28,29)(H,30,31)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)


Article DOI: 10.1021/jm950874+
BindingDB Entry DOI: 10.7270/Q20G3H9T
More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM87738
PNG
(US9695200, 11)
Show SMILES COc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cc(NC(=O)C=C)cc(c1)C(F)(F)F
Show InChI InChI=1S/C23H17F3N4O2/c1-3-20(31)30-17-7-14(6-16(10-17)23(24,25)26)15-8-18-19(12-29-22(18)28-11-15)13-4-5-27-21(9-13)32-2/h3-12H,1H2,2H3,(H,28,29)(H,30,31)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)


Article DOI: 10.1021/jm950874+
BindingDB Entry DOI: 10.7270/Q20G3H9T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM87754
PNG
(US9695200, 12)
Show SMILES C=CC(=O)Nc1cccc(c1)-c1cnc2[nH]cc(-c3cccnc3)c2c1
Show InChI InChI=1S/C21H16N4O/c1-2-20(26)25-17-7-3-5-14(9-17)16-10-18-19(13-24-21(18)23-12-16)15-6-4-8-22-11-15/h2-13H,1H2,(H,23,24)(H,25,26)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)


Article DOI: 10.1021/jm950874+
BindingDB Entry DOI: 10.7270/Q20G3H9T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM87774
PNG
(US9695200, 13)
Show SMILES Cn1cc(ccc1=O)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C22H18N4O2/c1-3-20(27)25-17-6-4-5-14(9-17)16-10-18-19(12-24-22(18)23-11-16)15-7-8-21(28)26(2)13-15/h3-13H,1H2,2H3,(H,23,24)(H,25,27)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)


Article DOI: 10.1021/jm950874+
BindingDB Entry DOI: 10.7270/Q20G3H9T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM87833
PNG
(US9695200, 14)
Show SMILES C=CC(=O)N[C@H]1CCN(C1)c1cnc2[nH]cc(-c3ccncc3)c2c1
Show InChI InChI=1S/C19H19N5O/c1-2-18(25)23-14-5-8-24(12-14)15-9-16-17(11-22-19(16)21-10-15)13-3-6-20-7-4-13/h2-4,6-7,9-11,14H,1,5,8,12H2,(H,21,22)(H,23,25)/t14-/m0/s1
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)


Article DOI: 10.1021/jm950874+
BindingDB Entry DOI: 10.7270/Q20G3H9T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM87847
PNG
(US9695200, 15)
Show SMILES C=CC(=O)N[C@H]1CCCN(C1)c1cnc2[nH]cc(-c3ccncc3)c2c1
Show InChI InChI=1S/C20H21N5O/c1-2-19(26)24-15-4-3-9-25(13-15)16-10-17-18(12-23-20(17)22-11-16)14-5-7-21-8-6-14/h2,5-8,10-12,15H,1,3-4,9,13H2,(H,22,23)(H,24,26)/t15-/m0/s1
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)


Article DOI: 10.1021/jm950874+
BindingDB Entry DOI: 10.7270/Q20G3H9T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM87948
PNG
(US9695200, 16)
Show SMILES C=CC(=O)Nc1cncc(c1)-c1cnc2[nH]cc(-c3ccncc3)c2c1
Show InChI InChI=1S/C20H15N5O/c1-2-19(26)25-16-7-14(9-22-11-16)15-8-17-18(12-24-20(17)23-10-15)13-3-5-21-6-4-13/h2-12H,1H2,(H,23,24)(H,25,26)
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n/an/a<1.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)


Article DOI: 10.1021/jm950874+
BindingDB Entry DOI: 10.7270/Q20G3H9T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM88373
PNG
(US9695200, 17)
Show SMILES Cn1cc(ccc1=O)-c1c[nH]c2ncc(cc12)-c1cncc(NC(=O)C=C)c1
Show InChI InChI=1S/C21H17N5O2/c1-3-19(27)25-16-6-14(8-22-10-16)15-7-17-18(11-24-21(17)23-9-15)13-4-5-20(28)26(2)12-13/h3-12H,1H2,2H3,(H,23,24)(H,25,27)
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n/an/a<1.00E+3n/an/an/an/an/an/a



Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)


Article DOI: 10.1021/jm950874+
BindingDB Entry DOI: 10.7270/Q20G3H9T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM88374
PNG
(US9695200, 18)
Show SMILES N#CN[C@H]1CCN(C1)c1cnc2[nH]cc(-c3ccncc3)c2c1
Show InChI InChI=1S/C17H16N6/c18-11-22-13-3-6-23(10-13)14-7-15-16(9-21-17(15)20-8-14)12-1-4-19-5-2-12/h1-2,4-5,7-9,13,22H,3,6,10H2,(H,20,21)/t13-/m0/s1
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)


Article DOI: 10.1021/jm950874+
BindingDB Entry DOI: 10.7270/Q20G3H9T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM88391
PNG
(US9695200, 19)
Show SMILES C=CC(=O)Nc1cc(cc(c1)-c1cnc2[nH]cc(-c3ccncc3)c2c1)C#N
Show InChI InChI=1S/C22H15N5O/c1-2-21(28)27-18-8-14(11-23)7-16(9-18)17-10-19-20(13-26-22(19)25-12-17)15-3-5-24-6-4-15/h2-10,12-13H,1H2,(H,25,26)(H,27,28)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)


Article DOI: 10.1021/jm950874+
BindingDB Entry DOI: 10.7270/Q20G3H9T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM88535
PNG
(US9695200, 20)
Show SMILES FC(F)(F)c1cc(NC(=O)C=C)cc(c1)-c1cnc2[nH]cc(-c3ccncc3)c2c1
Show InChI InChI=1S/C22H15F3N4O/c1-2-20(30)29-17-8-14(7-16(10-17)22(23,24)25)15-9-18-19(12-28-21(18)27-11-15)13-3-5-26-6-4-13/h2-12H,1H2,(H,27,28)(H,29,30)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)


Article DOI: 10.1021/jm950874+
BindingDB Entry DOI: 10.7270/Q20G3H9T
More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM88535
PNG
(US9695200, 20)
Show SMILES FC(F)(F)c1cc(NC(=O)C=C)cc(c1)-c1cnc2[nH]cc(-c3ccncc3)c2c1
Show InChI InChI=1S/C22H15F3N4O/c1-2-20(30)29-17-8-14(7-16(10-17)22(23,24)25)15-9-18-19(12-28-21(18)27-11-15)13-3-5-26-6-4-13/h2-12H,1H2,(H,27,28)(H,29,30)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)


Article DOI: 10.1021/jm950874+
BindingDB Entry DOI: 10.7270/Q20G3H9T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM88537
PNG
(US9695200, 21)
Show SMILES COc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cccc(c1)N(C)C(=O)C=C
Show InChI InChI=1S/C23H20N4O2/c1-4-22(28)27(2)18-7-5-6-15(10-18)17-11-19-20(14-26-23(19)25-13-17)16-8-9-24-21(12-16)29-3/h4-14H,1H2,2-3H3,(H,25,26)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)


Article DOI: 10.1021/jm950874+
BindingDB Entry DOI: 10.7270/Q20G3H9T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM88551
PNG
(US9695200, 22)
Show SMILES COc1cc(NC(=O)C=C)cc(c1)-c1cnc2[nH]cc(-c3ccncc3)c2c1
Show InChI InChI=1S/C22H18N4O2/c1-3-21(27)26-17-8-15(9-18(11-17)28-2)16-10-19-20(13-25-22(19)24-12-16)14-4-6-23-7-5-14/h3-13H,1H2,2H3,(H,24,25)(H,26,27)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)


Article DOI: 10.1021/jm950874+
BindingDB Entry DOI: 10.7270/Q20G3H9T
More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM88551
PNG
(US9695200, 22)
Show SMILES COc1cc(NC(=O)C=C)cc(c1)-c1cnc2[nH]cc(-c3ccncc3)c2c1
Show InChI InChI=1S/C22H18N4O2/c1-3-21(27)26-17-8-15(9-18(11-17)28-2)16-10-19-20(13-25-22(19)24-12-16)14-4-6-23-7-5-14/h3-13H,1H2,2H3,(H,24,25)(H,26,27)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)


Article DOI: 10.1021/jm950874+
BindingDB Entry DOI: 10.7270/Q20G3H9T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM88558
PNG
(US9695200, 23)
Show SMILES O=C(Nc1cccc(c1)-c1cnc2[nH]cc(-c3ccncc3)c2c1)\C=C\CN1CCOCC1
Show InChI InChI=1S/C26H25N5O2/c32-25(5-2-10-31-11-13-33-14-12-31)30-22-4-1-3-20(15-22)21-16-23-24(18-29-26(23)28-17-21)19-6-8-27-9-7-19/h1-9,15-18H,10-14H2,(H,28,29)(H,30,32)/b5-2+
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)


Article DOI: 10.1021/jm950874+
BindingDB Entry DOI: 10.7270/Q20G3H9T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM88562
PNG
(US9695200, 24)
Show SMILES CN(C)C\C=C\C(=O)Nc1cccc(c1)-c1cnc2[nH]cc(-c3ccncc3)c2c1
Show InChI InChI=1S/C24H23N5O/c1-29(2)12-4-7-23(30)28-20-6-3-5-18(13-20)19-14-21-22(16-27-24(21)26-15-19)17-8-10-25-11-9-17/h3-11,13-16H,12H2,1-2H3,(H,26,27)(H,28,30)/b7-4+
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)


Article DOI: 10.1021/jm950874+
BindingDB Entry DOI: 10.7270/Q20G3H9T
More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM88562
PNG
(US9695200, 24)
Show SMILES CN(C)C\C=C\C(=O)Nc1cccc(c1)-c1cnc2[nH]cc(-c3ccncc3)c2c1
Show InChI InChI=1S/C24H23N5O/c1-29(2)12-4-7-23(30)28-20-6-3-5-18(13-20)19-14-21-22(16-27-24(21)26-15-19)17-8-10-25-11-9-17/h3-11,13-16H,12H2,1-2H3,(H,26,27)(H,28,30)/b7-4+
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Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)


Article DOI: 10.1021/jm950874+
BindingDB Entry DOI: 10.7270/Q20G3H9T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM88653
PNG
(US9695200, 25)
Show SMILES Fc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C21H15FN4O/c1-2-20(27)26-16-5-3-4-13(8-16)15-9-17-18(12-25-21(17)24-11-15)14-6-7-23-19(22)10-14/h2-12H,1H2,(H,24,25)(H,26,27)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)


Article DOI: 10.1021/jm950874+
BindingDB Entry DOI: 10.7270/Q20G3H9T
More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM88653
PNG
(US9695200, 25)
Show SMILES Fc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C21H15FN4O/c1-2-20(27)26-16-5-3-4-13(8-16)15-9-17-18(12-25-21(17)24-11-15)14-6-7-23-19(22)10-14/h2-12H,1H2,(H,24,25)(H,26,27)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)


Article DOI: 10.1021/jm950874+
BindingDB Entry DOI: 10.7270/Q20G3H9T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM88670
PNG
(US9695200, 26)
Show SMILES Cc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C22H18N4O/c1-3-21(27)26-18-6-4-5-15(10-18)17-11-19-20(13-25-22(19)24-12-17)16-7-8-23-14(2)9-16/h3-13H,1H2,2H3,(H,24,25)(H,26,27)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)


Article DOI: 10.1021/jm950874+
BindingDB Entry DOI: 10.7270/Q20G3H9T
More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM88670
PNG
(US9695200, 26)
Show SMILES Cc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C22H18N4O/c1-3-21(27)26-18-6-4-5-15(10-18)17-11-19-20(13-25-22(19)24-12-17)16-7-8-23-14(2)9-16/h3-13H,1H2,2H3,(H,24,25)(H,26,27)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)


Article DOI: 10.1021/jm950874+
BindingDB Entry DOI: 10.7270/Q20G3H9T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM98741
PNG
(US9695200, 27)
Show SMILES Fc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cncc(NC(=O)C=C)c1
Show InChI InChI=1S/C20H14FN5O/c1-2-19(27)26-15-5-13(8-22-10-15)14-6-16-17(11-25-20(16)24-9-14)12-3-4-23-18(21)7-12/h2-11H,1H2,(H,24,25)(H,26,27)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)


Article DOI: 10.1021/jm950874+
BindingDB Entry DOI: 10.7270/Q20G3H9T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM98760
PNG
(US9695200, 28)
Show SMILES Cc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cncc(NC(=O)C=C)c1
Show InChI InChI=1S/C21H17N5O/c1-3-20(27)26-17-7-15(9-22-11-17)16-8-18-19(12-25-21(18)24-10-16)14-4-5-23-13(2)6-14/h3-12H,1H2,2H3,(H,24,25)(H,26,27)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)


Article DOI: 10.1021/jm950874+
BindingDB Entry DOI: 10.7270/Q20G3H9T
More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM98760
PNG
(US9695200, 28)
Show SMILES Cc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cncc(NC(=O)C=C)c1
Show InChI InChI=1S/C21H17N5O/c1-3-20(27)26-17-7-15(9-22-11-17)16-8-18-19(12-25-21(18)24-10-16)14-4-5-23-13(2)6-14/h3-12H,1H2,2H3,(H,24,25)(H,26,27)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)


Article DOI: 10.1021/jm950874+
BindingDB Entry DOI: 10.7270/Q20G3H9T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM98772
PNG
(US9695200, 29)
Show SMILES COc1cc(cc(C)n1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C23H20N4O2/c1-4-21(28)27-18-7-5-6-15(9-18)17-10-19-20(13-25-23(19)24-12-17)16-8-14(2)26-22(11-16)29-3/h4-13H,1H2,2-3H3,(H,24,25)(H,27,28)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)


Article DOI: 10.1021/jm950874+
BindingDB Entry DOI: 10.7270/Q20G3H9T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM98779
PNG
(US9695200, 30)
Show SMILES COc1ccc(cn1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C22H18N4O2/c1-3-20(27)26-17-6-4-5-14(9-17)16-10-18-19(13-25-22(18)24-12-16)15-7-8-21(28-2)23-11-15/h3-13H,1H2,2H3,(H,24,25)(H,26,27)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)


Article DOI: 10.1021/jm950874+
BindingDB Entry DOI: 10.7270/Q20G3H9T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM98781
PNG
(US9695200, 31)
Show SMILES COc1cc(cc(n1)C(F)(F)F)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C23H17F3N4O2/c1-3-20(31)29-16-6-4-5-13(7-16)15-8-17-18(12-28-22(17)27-11-15)14-9-19(23(24,25)26)30-21(10-14)32-2/h3-12H,1H2,2H3,(H,27,28)(H,29,31)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)


Article DOI: 10.1021/jm950874+
BindingDB Entry DOI: 10.7270/Q20G3H9T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM98786
PNG
(US9695200, 32)
Show SMILES CNc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C22H19N5O/c1-3-21(28)27-17-6-4-5-14(9-17)16-10-18-19(13-26-22(18)25-12-16)15-7-8-24-20(11-15)23-2/h3-13H,1H2,2H3,(H,23,24)(H,25,26)(H,27,28)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)


Article DOI: 10.1021/jm950874+
BindingDB Entry DOI: 10.7270/Q20G3H9T
More data for this
Ligand-Target Pair
Phospholipase C-gamma-1


(Homo sapiens)
BDBM98786
PNG
(US9695200, 32)
Show SMILES CNc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C22H19N5O/c1-3-21(28)27-17-6-4-5-14(9-17)16-10-18-19(13-26-22(18)25-12-16)15-7-8-24-20(11-15)23-2/h3-13H,1H2,2H3,(H,23,24)(H,25,26)(H,27,28)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
Compounds were serially diluted into DMSO, and then into media to concentrations 10 that of the final assay concentration. Compounds were then added...


US Patent US9695200 (2017)


Article DOI: 10.1021/jm950874+
BindingDB Entry DOI: 10.7270/Q20G3H9T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM98793
PNG
(US9695200, 33)
Show SMILES Cc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cccc(\C=C(/C#N)C(N)=O)c1
Show InChI InChI=1S/C23H17N5O/c1-14-7-17(5-6-26-14)21-13-28-23-20(21)10-19(12-27-23)16-4-2-3-15(8-16)9-18(11-24)22(25)29/h2-10,12-13H,1H3,(H2,25,29)(H,27,28)/b18-9+
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)


Article DOI: 10.1021/jm950874+
BindingDB Entry DOI: 10.7270/Q20G3H9T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM98797
PNG
(US9695200, 34)
Show SMILES CN(C)C\C=C\C(=O)Nc1cccc(c1)-c1cnc2[nH]cc(-c3ccc(=O)n(C)c3)c2c1
Show InChI InChI=1S/C25H25N5O2/c1-29(2)11-5-8-23(31)28-20-7-4-6-17(12-20)19-13-21-22(15-27-25(21)26-14-19)18-9-10-24(32)30(3)16-18/h4-10,12-16H,11H2,1-3H3,(H,26,27)(H,28,31)/b8-5+
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)


Article DOI: 10.1021/jm950874+
BindingDB Entry DOI: 10.7270/Q20G3H9T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM98801
PNG
(US9695200, 35)
Show SMILES Fc1cc(ccn1)-c1c[nH]c2ncc(cc12)N1CC(C1)NC(=O)C=C
Show InChI InChI=1S/C18H16FN5O/c1-2-17(25)23-12-9-24(10-12)13-6-14-15(8-22-18(14)21-7-13)11-3-4-20-16(19)5-11/h2-8,12H,1,9-10H2,(H,21,22)(H,23,25)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)


Article DOI: 10.1021/jm950874+
BindingDB Entry DOI: 10.7270/Q20G3H9T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM98805
PNG
(US9695200, 36)
Show SMILES CNc1cc(ccn1)-c1c[nH]c2ncc(cc12)N1CC(C1)NC(=O)C=C
Show InChI InChI=1S/C19H20N6O/c1-3-18(26)24-13-10-25(11-13)14-7-15-16(9-23-19(15)22-8-14)12-4-5-21-17(6-12)20-2/h3-9,13H,1,10-11H2,2H3,(H,20,21)(H,22,23)(H,24,26)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)


Article DOI: 10.1021/jm950874+
BindingDB Entry DOI: 10.7270/Q20G3H9T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM98807
PNG
(US9695200, 37)
Show SMILES COc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)\C=C\CN(C)C)c1
Show InChI InChI=1S/C25H25N5O2/c1-30(2)11-5-8-23(31)29-20-7-4-6-17(12-20)19-13-21-22(16-28-25(21)27-15-19)18-9-10-26-24(14-18)32-3/h4-10,12-16H,11H2,1-3H3,(H,27,28)(H,29,31)/b8-5+
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)


Article DOI: 10.1021/jm950874+
BindingDB Entry DOI: 10.7270/Q20G3H9T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM98809
PNG
(US9695200, 38)
Show SMILES COc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)\C=C\CN2CCOCC2)c1
Show InChI InChI=1S/C27H27N5O3/c1-34-26-16-20(7-8-28-26)24-18-30-27-23(24)15-21(17-29-27)19-4-2-5-22(14-19)31-25(33)6-3-9-32-10-12-35-13-11-32/h2-8,14-18H,9-13H2,1H3,(H,29,30)(H,31,33)/b6-3+
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)


Article DOI: 10.1021/jm950874+
BindingDB Entry DOI: 10.7270/Q20G3H9T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM98813
PNG
(US9695200, 39)
Show SMILES COc1cc(ncn1)-c1c[nH]c2ncc(cc12)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C21H17N5O2/c1-3-19(27)26-15-6-4-5-13(7-15)14-8-16-17(11-23-21(16)22-10-14)18-9-20(28-2)25-12-24-18/h3-12H,1H2,2H3,(H,22,23)(H,26,27)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)


Article DOI: 10.1021/jm950874+
BindingDB Entry DOI: 10.7270/Q20G3H9T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM98815
PNG
(US9695200, 40)
Show SMILES COc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cc(NC(=O)C=C)nc(OC)c1
Show InChI InChI=1S/C22H19N5O3/c1-4-19(28)26-18-8-14(10-21(27-18)30-3)15-7-16-17(12-25-22(16)24-11-15)13-5-6-23-20(9-13)29-2/h4-12H,1H2,2-3H3,(H,24,25)(H,26,27,28)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)


Article DOI: 10.1021/jm950874+
BindingDB Entry DOI: 10.7270/Q20G3H9T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ITK/TSK


(Homo sapiens)
BDBM98821
PNG
(US9695200, 41)
Show SMILES COc1cc(ccn1)-c1c[nH]c2ncc(cc12)-c1cc(NC(=O)C=C)nc(c1)N1CCOCC1
Show InChI InChI=1S/C25H24N6O3/c1-3-23(32)30-21-11-17(12-22(29-21)31-6-8-34-9-7-31)18-10-19-20(15-28-25(19)27-14-18)16-4-5-26-24(13-16)33-2/h3-5,10-15H,1,6-9H2,2H3,(H,27,28)(H,29,30,32)
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Confluence Life Sciences, Inc.

US Patent


Assay Description
This assay is based on the binding of a proprietary, Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor (kinase tracer-236) to the ITK express...


US Patent US9695200 (2017)


Article DOI: 10.1021/jm950874+
BindingDB Entry DOI: 10.7270/Q20G3H9T
More data for this
Ligand-Target Pair
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