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Compile Data Set for Download or QSAR

Found 27 hits from Conopco, Inc.   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM310976
PNG
(US10155733, Example 5 | US10155733, Strucure 3e)
Show SMILES CN1CCCN(CC1)C(=O)C(O)(C1CCCC1)c1ccccc1
Show InChI InChI=1S/C19H28N2O2/c1-20-12-7-13-21(15-14-20)18(22)19(23,17-10-5-6-11-17)16-8-3-2-4-9-16/h2-4,8-9,17,23H,5-7,10-15H2,1H3
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n/an/a 9.5n/an/an/an/an/an/a



Conopco, Inc.

US Patent


Assay Description
The muscarinic 3 receptor binding assay was adapted from Perkin Elmer. Briefly, assay buffer (60 μL of pH 7.4 phosphate saline buffer) was added...


US Patent US10155733 (2018)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM311052
PNG
(US10155733, Example 7 | US10155733, Strucure 3g)
Show SMILES CN1CCCN(CC1)C(=O)C(O)(C1CCCCC1)c1ccccc1
Show InChI InChI=1S/C20H30N2O2/c1-21-13-8-14-22(16-15-21)19(23)20(24,17-9-4-2-5-10-17)18-11-6-3-7-12-18/h2,4-5,9-10,18,24H,3,6-8,11-16H2,1H3
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n/an/a 60n/an/an/an/an/an/a



Conopco, Inc.

US Patent


Assay Description
The muscarinic 3 receptor binding assay was adapted from Perkin Elmer. Briefly, assay buffer (60 μL of pH 7.4 phosphate saline buffer) was added...


US Patent US10155733 (2018)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM311058
PNG
(US10155733, Example 11 | US10155733, Strucure 7d)
Show SMILES OC(C1CCCC1)(C(=O)N1CCN(CCCc2ccccc2)CC1)c1ccccc1
Show InChI InChI=1S/C26H34N2O2/c29-25(26(30,24-15-7-8-16-24)23-13-5-2-6-14-23)28-20-18-27(19-21-28)17-9-12-22-10-3-1-4-11-22/h1-6,10-11,13-14,24,30H,7-9,12,15-21H2
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Conopco, Inc.

US Patent


Assay Description
The muscarinic 3 receptor binding assay was adapted from Perkin Elmer. Briefly, assay buffer (60 μL of pH 7.4 phosphate saline buffer) was added...


US Patent US10155733 (2018)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM311061
PNG
(US10155733, Example 14 | US10155733, Strucure 7g)
Show SMILES CC(CCc1ccccc1)N1CCN(CC1)C(=O)C(O)(C1CCCC1)c1ccccc1
Show InChI InChI=1S/C27H36N2O2/c1-22(16-17-23-10-4-2-5-11-23)28-18-20-29(21-19-28)26(30)27(31,25-14-8-9-15-25)24-12-6-3-7-13-24/h2-7,10-13,22,25,31H,8-9,14-21H2,1H3
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Conopco, Inc.

US Patent


Assay Description
The muscarinic 3 receptor binding assay was adapted from Perkin Elmer. Briefly, assay buffer (60 μL of pH 7.4 phosphate saline buffer) was added...


US Patent US10155733 (2018)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM311059
PNG
(US10155733, Example 12 | US10155733, Strucure 7e)
Show SMILES OC(C1CCCC1)(C(=O)N1CCN(C\C=C\c2ccccc2)CC1)c1ccccc1
Show InChI InChI=1S/C26H32N2O2/c29-25(26(30,24-15-7-8-16-24)23-13-5-2-6-14-23)28-20-18-27(19-21-28)17-9-12-22-10-3-1-4-11-22/h1-6,9-14,24,30H,7-8,15-21H2/b12-9+
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Conopco, Inc.

US Patent


Assay Description
The muscarinic 3 receptor binding assay was adapted from Perkin Elmer. Briefly, assay buffer (60 μL of pH 7.4 phosphate saline buffer) was added...


US Patent US10155733 (2018)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM311064
PNG
(US10155733, Example 17 | US10155733, Strucure 7j)
Show SMILES OC(C1CCCC1)(C(=O)N1CCCN(CCCc2ccccc2)CC1)c1ccccc1
Show InChI InChI=1S/C27H36N2O2/c30-26(27(31,25-16-7-8-17-25)24-14-5-2-6-15-24)29-20-10-19-28(21-22-29)18-9-13-23-11-3-1-4-12-23/h1-6,11-12,14-15,25,31H,7-10,13,16-22H2
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Conopco, Inc.

US Patent


Assay Description
The muscarinic 3 receptor binding assay was adapted from Perkin Elmer. Briefly, assay buffer (60 μL of pH 7.4 phosphate saline buffer) was added...


US Patent US10155733 (2018)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM311070
PNG
(US10155733, Example 23 | US10155733, Strucure 9f)
Show SMILES OC(C1CCCC1)(C(=O)N1CCN(CCC(=O)c2ccccc2)CC1)c1ccccc1
Show InChI InChI=1S/C26H32N2O3/c29-24(21-9-3-1-4-10-21)15-16-27-17-19-28(20-18-27)25(30)26(31,23-13-7-8-14-23)22-11-5-2-6-12-22/h1-6,9-12,23,31H,7-8,13-20H2
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Conopco, Inc.

US Patent


Assay Description
The muscarinic 3 receptor binding assay was adapted from Perkin Elmer. Briefly, assay buffer (60 μL of pH 7.4 phosphate saline buffer) was added...


US Patent US10155733 (2018)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM311068
PNG
(US10155733, Example 21 | US10155733, Strucure 9d)
Show SMILES COc1ccc(CCN2CCN(CC2)C(=O)C(O)(C2CCCC2)c2ccccc2)cc1
Show InChI InChI=1S/C26H34N2O3/c1-31-24-13-11-21(12-14-24)15-16-27-17-19-28(20-18-27)25(29)26(30,23-9-5-6-10-23)22-7-3-2-4-8-22/h2-4,7-8,11-14,23,30H,5-6,9-10,15-20H2,1H3
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Conopco, Inc.

US Patent


Assay Description
The muscarinic 3 receptor binding assay was adapted from Perkin Elmer. Briefly, assay buffer (60 μL of pH 7.4 phosphate saline buffer) was added...


US Patent US10155733 (2018)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM311051
PNG
(US10155733, Example 6 | US10155733, Strucure 3f)
Show SMILES CN1CCCN(CC1)C(=O)C(C1CCCC1)c1ccccc1
Show InChI InChI=1S/C19H28N2O/c1-20-12-7-13-21(15-14-20)19(22)18(17-10-5-6-11-17)16-8-3-2-4-9-16/h2-4,8-9,17-18H,5-7,10-15H2,1H3
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Conopco, Inc.

US Patent


Assay Description
The muscarinic 3 receptor binding assay was adapted from Perkin Elmer. Briefly, assay buffer (60 μL of pH 7.4 phosphate saline buffer) was added...


US Patent US10155733 (2018)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM311056
PNG
(US10155733, Example 10 | US10155733, Strucure 7c)
Show SMILES O=C(C(C1CCCC1)c1ccccc1)N1CCN(C\C=C\c2ccccc2)CC1
Show InChI InChI=1S/C26H32N2O/c29-26(25(24-15-7-8-16-24)23-13-5-2-6-14-23)28-20-18-27(19-21-28)17-9-12-22-10-3-1-4-11-22/h1-6,9-14,24-25H,7-8,15-21H2/b12-9+
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Conopco, Inc.

US Patent


Assay Description
The muscarinic 3 receptor binding assay was adapted from Perkin Elmer. Briefly, assay buffer (60 μL of pH 7.4 phosphate saline buffer) was added...


US Patent US10155733 (2018)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM311066
PNG
(US10155733, Example 19 | US10155733, Strucure 9b)
Show SMILES OC(C1CCCC1)(C(=O)N1CCN(CCCCc2ccccc2)CC1)c1ccccc1
Show InChI InChI=1S/C27H36N2O2/c30-26(27(31,25-16-7-8-17-25)24-14-5-2-6-15-24)29-21-19-28(20-22-29)18-10-9-13-23-11-3-1-4-12-23/h1-6,11-12,14-15,25,31H,7-10,13,16-22H2
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Conopco, Inc.

US Patent


Assay Description
The muscarinic 3 receptor binding assay was adapted from Perkin Elmer. Briefly, assay buffer (60 μL of pH 7.4 phosphate saline buffer) was added...


US Patent US10155733 (2018)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM311067
PNG
(US10155733, Example 20 | US10155733, Strucure 9c)
Show SMILES OC(C1CCCC1)(C(=O)N1CCN(CCOc2ccccc2)CC1)c1ccccc1
Show InChI InChI=1S/C25H32N2O3/c28-24(25(29,22-11-7-8-12-22)21-9-3-1-4-10-21)27-17-15-26(16-18-27)19-20-30-23-13-5-2-6-14-23/h1-6,9-10,13-14,22,29H,7-8,11-12,15-20H2
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Conopco, Inc.

US Patent


Assay Description
The muscarinic 3 receptor binding assay was adapted from Perkin Elmer. Briefly, assay buffer (60 μL of pH 7.4 phosphate saline buffer) was added...


US Patent US10155733 (2018)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM310964
PNG
(US10155733, Example 3 | US10155733, Strucure 3c)
Show SMILES CN1CCN(CC1)C(=O)C(O)(C1CCCC1)c1ccccc1
Show InChI InChI=1S/C18H26N2O2/c1-19-11-13-20(14-12-19)17(21)18(22,16-9-5-6-10-16)15-7-3-2-4-8-15/h2-4,7-8,16,22H,5-6,9-14H2,1H3
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Conopco, Inc.

US Patent


Assay Description
The muscarinic 3 receptor binding assay was adapted from Perkin Elmer. Briefly, assay buffer (60 μL of pH 7.4 phosphate saline buffer) was added...


US Patent US10155733 (2018)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM311074
PNG
(US10155733, Example 27 | US10155733, Strucure 13)
Show SMILES OC(C1CCCC1)(C(=O)N1CCN(CC1)C(=O)CCc1ccccc1)c1ccccc1
Show InChI InChI=1S/C26H32N2O3/c29-24(16-15-21-9-3-1-4-10-21)27-17-19-28(20-18-27)25(30)26(31,23-13-7-8-14-23)22-11-5-2-6-12-22/h1-6,9-12,23,31H,7-8,13-20H2
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Conopco, Inc.

US Patent


Assay Description
The muscarinic 3 receptor binding assay was adapted from Perkin Elmer. Briefly, assay buffer (60 μL of pH 7.4 phosphate saline buffer) was added...


US Patent US10155733 (2018)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM311053
PNG
(US10155733, Example 8 | US10155733, Strucure 7a)
Show SMILES O=C(C(C1CCCC1)c1ccccc1)N1CCN(CCc2ccccc2)CC1
Show InChI InChI=1S/C25H32N2O/c28-25(24(23-13-7-8-14-23)22-11-5-2-6-12-22)27-19-17-26(18-20-27)16-15-21-9-3-1-4-10-21/h1-6,9-12,23-24H,7-8,13-20H2
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Conopco, Inc.

US Patent


Assay Description
The muscarinic 3 receptor binding assay was adapted from Perkin Elmer. Briefly, assay buffer (60 μL of pH 7.4 phosphate saline buffer) was added...


US Patent US10155733 (2018)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM311054
PNG
(US10155733, Example 9 | US10155733, Strucure 7b)
Show SMILES O=C(C(C1CCCC1)c1ccccc1)N1CCN(CCCc2ccccc2)CC1
Show InChI InChI=1S/C26H34N2O/c29-26(25(24-15-7-8-16-24)23-13-5-2-6-14-23)28-20-18-27(19-21-28)17-9-12-22-10-3-1-4-11-22/h1-6,10-11,13-14,24-25H,7-9,12,15-21H2
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Conopco, Inc.

US Patent


Assay Description
The muscarinic 3 receptor binding assay was adapted from Perkin Elmer. Briefly, assay buffer (60 μL of pH 7.4 phosphate saline buffer) was added...


US Patent US10155733 (2018)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM310951
PNG
(US10155733, Example 2 | US10155733, Strucure 3b)
Show SMILES CN1CCN(CC1)C(=O)C(C1CCCC1)c1ccccc1
Show InChI InChI=1S/C18H26N2O/c1-19-11-13-20(14-12-19)18(21)17(16-9-5-6-10-16)15-7-3-2-4-8-15/h2-4,7-8,16-17H,5-6,9-14H2,1H3
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Conopco, Inc.

US Patent


Assay Description
The muscarinic 3 receptor binding assay was adapted from Perkin Elmer. Briefly, assay buffer (60 μL of pH 7.4 phosphate saline buffer) was added...


US Patent US10155733 (2018)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM311072
PNG
(US10155733, Example 25 | US10155733, Strucure 9h)
Show SMILES OC(C1CCCC1)(C(=O)N1CCN(CC(=O)c2ccccc2)CC1)c1ccccc1
Show InChI InChI=1S/C25H30N2O3/c28-23(20-9-3-1-4-10-20)19-26-15-17-27(18-16-26)24(29)25(30,22-13-7-8-14-22)21-11-5-2-6-12-21/h1-6,9-12,22,30H,7-8,13-19H2
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Conopco, Inc.

US Patent


Assay Description
The muscarinic 3 receptor binding assay was adapted from Perkin Elmer. Briefly, assay buffer (60 μL of pH 7.4 phosphate saline buffer) was added...


US Patent US10155733 (2018)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM311062
PNG
(US10155733, Example 15 | US10155733, Strucure 7h)
Show SMILES COc1ccc(CC(C)N2CCN(CC2)C(=O)C(O)(C2CCCC2)c2ccccc2)cc1
Show InChI InChI=1S/C27H36N2O3/c1-21(20-22-12-14-25(32-2)15-13-22)28-16-18-29(19-17-28)26(30)27(31,24-10-6-7-11-24)23-8-4-3-5-9-23/h3-5,8-9,12-15,21,24,31H,6-7,10-11,16-20H2,1-2H3
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n/an/a 3.00E+3n/an/an/an/an/an/a



Conopco, Inc.

US Patent


Assay Description
The muscarinic 3 receptor binding assay was adapted from Perkin Elmer. Briefly, assay buffer (60 μL of pH 7.4 phosphate saline buffer) was added...


US Patent US10155733 (2018)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM311071
PNG
(US10155733, Example 24 | US10155733, Strucure 9g)
Show SMILES COc1ccc(cc1)C(=O)CN1CCN(CC1)C(=O)C(O)(C1CCCC1)c1ccccc1
Show InChI InChI=1S/C26H32N2O4/c1-32-23-13-11-20(12-14-23)24(29)19-27-15-17-28(18-16-27)25(30)26(31,22-9-5-6-10-22)21-7-3-2-4-8-21/h2-4,7-8,11-14,22,31H,5-6,9-10,15-19H2,1H3
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n/an/a 3.90E+3n/an/an/an/an/an/a



Conopco, Inc.

US Patent


Assay Description
The muscarinic 3 receptor binding assay was adapted from Perkin Elmer. Briefly, assay buffer (60 μL of pH 7.4 phosphate saline buffer) was added...


US Patent US10155733 (2018)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM311073
PNG
(US10155733, Example 26 | US10155733, Strucure 11)
Show SMILES OC(CN1CCN(CC1)C(=O)C(O)(C1CCCC1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C25H32N2O3/c28-23(20-9-3-1-4-10-20)19-26-15-17-27(18-16-26)24(29)25(30,22-13-7-8-14-22)21-11-5-2-6-12-21/h1-6,9-12,22-23,28,30H,7-8,13-19H2
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n/an/a 4.30E+3n/an/an/an/an/an/a



Conopco, Inc.

US Patent


Assay Description
The muscarinic 3 receptor binding assay was adapted from Perkin Elmer. Briefly, assay buffer (60 μL of pH 7.4 phosphate saline buffer) was added...


US Patent US10155733 (2018)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM311063
PNG
(US10155733, Example 16 | US10155733, Strucure 7i)
Show SMILES CC(CN1CCN(CC1)C(=O)C(O)(C1CCCC1)c1ccccc1)Cc1ccc2OCOc2c1
Show InChI InChI=1S/C28H36N2O4/c1-21(17-22-11-12-25-26(18-22)34-20-33-25)19-29-13-15-30(16-14-29)27(31)28(32,24-9-5-6-10-24)23-7-3-2-4-8-23/h2-4,7-8,11-12,18,21,24,32H,5-6,9-10,13-17,19-20H2,1H3
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n/an/a 4.60E+3n/an/an/an/an/an/a



Conopco, Inc.

US Patent


Assay Description
The muscarinic 3 receptor binding assay was adapted from Perkin Elmer. Briefly, assay buffer (60 μL of pH 7.4 phosphate saline buffer) was added...


US Patent US10155733 (2018)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM311060
PNG
(US10155733, Example 13 | US10155733, Strucure 7f)
Show SMILES OC(C1CCCC1)(C(=O)N1CCN(CCc2ccccc2)CC1)c1ccccc1
Show InChI InChI=1S/C25H32N2O2/c28-24(25(29,23-13-7-8-14-23)22-11-5-2-6-12-22)27-19-17-26(18-20-27)16-15-21-9-3-1-4-10-21/h1-6,9-12,23,29H,7-8,13-20H2
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UniChem
US Patent
n/an/a 4.70E+3n/an/an/an/an/an/a



Conopco, Inc.

US Patent


Assay Description
The muscarinic 3 receptor binding assay was adapted from Perkin Elmer. Briefly, assay buffer (60 μL of pH 7.4 phosphate saline buffer) was added...


US Patent US10155733 (2018)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM310949
PNG
(US10155733, Example 1 | US10155733, Strucure 3a)
Show SMILES CN1CCN(CC1)C(=O)C(C1CCCCC1)c1ccccc1
Show InChI InChI=1S/C19H28N2O/c1-20-12-14-21(15-13-20)19(22)18(16-8-4-2-5-9-16)17-10-6-3-7-11-17/h2,4-5,8-9,17-18H,3,6-7,10-15H2,1H3
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UniChem
US Patent
n/an/a 5.30E+3n/an/an/an/an/an/a



Conopco, Inc.

US Patent


Assay Description
The muscarinic 3 receptor binding assay was adapted from Perkin Elmer. Briefly, assay buffer (60 μL of pH 7.4 phosphate saline buffer) was added...


US Patent US10155733 (2018)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM311069
PNG
(US10155733, Example 22 | US10155733, Strucure 9e)
Show SMILES COc1ccc(CCN2CCN(CC2)C(=O)C(O)(C2CCCC2)c2ccccc2)cc1OC
Show InChI InChI=1S/C27H36N2O4/c1-32-24-13-12-21(20-25(24)33-2)14-15-28-16-18-29(19-17-28)26(30)27(31,23-10-6-7-11-23)22-8-4-3-5-9-22/h3-5,8-9,12-13,20,23,31H,6-7,10-11,14-19H2,1-2H3
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US Patent
n/an/a 5.70E+3n/an/an/an/an/an/a



Conopco, Inc.

US Patent


Assay Description
The muscarinic 3 receptor binding assay was adapted from Perkin Elmer. Briefly, assay buffer (60 μL of pH 7.4 phosphate saline buffer) was added...


US Patent US10155733 (2018)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM311065
PNG
(US10155733, Example 18 | US10155733, Strucure 9a)
Show SMILES O=C(C(C1CCCC1)c1ccccc1)N1CCN(CCC2CCCCC2)CC1
Show InChI InChI=1S/C25H38N2O/c28-25(24(23-13-7-8-14-23)22-11-5-2-6-12-22)27-19-17-26(18-20-27)16-15-21-9-3-1-4-10-21/h2,5-6,11-12,21,23-24H,1,3-4,7-10,13-20H2
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US Patent
n/an/a 6.00E+3n/an/an/an/an/an/a



Conopco, Inc.

US Patent


Assay Description
The muscarinic 3 receptor binding assay was adapted from Perkin Elmer. Briefly, assay buffer (60 μL of pH 7.4 phosphate saline buffer) was added...


US Patent US10155733 (2018)

More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM310972
PNG
(US10155733, Example 4 | US10155733, Strucure 3d)
Show SMILES CCCCCCN1CCN(CC1)C(=O)C(C1CCCC1)c1ccccc1
Show InChI InChI=1S/C23H36N2O/c1-2-3-4-10-15-24-16-18-25(19-17-24)23(26)22(21-13-8-9-14-21)20-11-6-5-7-12-20/h5-7,11-12,21-22H,2-4,8-10,13-19H2,1H3
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UniChem
US Patent
n/an/a 7.90E+3n/an/an/an/an/an/a



Conopco, Inc.

US Patent


Assay Description
The muscarinic 3 receptor binding assay was adapted from Perkin Elmer. Briefly, assay buffer (60 μL of pH 7.4 phosphate saline buffer) was added...


US Patent US10155733 (2018)

More data for this
Ligand-Target Pair