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Compile Data Set for Download or QSAR

Found 171 hits from Constellation Pharmaceuticals   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM50380682
PNG
(CHEMBL2017291 | I-BET151 (16))
Show SMILES COc1cc2c3n([C@H](C)c4ccccn4)c(=O)[nH]c3cnc2cc1-c1c(C)noc1C
Show InChI InChI=1/C23H21N5O3/c1-12-21(14(3)31-27-12)16-9-18-15(10-20(16)30-4)22-19(11-25-18)26-23(29)28(22)13(2)17-7-5-6-8-24-17/h5-11,13H,1-4H3,(H,26,29)/t13-/s2
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n/an/a 18n/an/an/an/an/an/a



Constellation Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of His-FLAG-tagged BRD4 binding domain1 (unknown origin) binding to H4-TetraAc-biotin peptide after 20 mins by AlphaLISA


ACS Med Chem Lett 4: 835-40 (2013)


Article DOI: 10.1021/ml4001485
BindingDB Entry DOI: 10.7270/Q2DV1MB8
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM50365262
PNG
( (S)-JQ1 (1) | CHEMBL1957266 | JQ1 | US10124009, C...)
Show SMILES Cc1nnc2[C@H](CC(=O)OC(C)(C)C)N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1
Show InChI InChI=1/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15)25-17(11-18(29)30-23(4,5)6)21-27-26-14(3)28(21)22/h7-10,17H,11H2,1-6H3/t17-/s2
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Constellation Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of His-FLAG-tagged BRD4 binding domain1 (unknown origin) binding to H4-TetraAc-biotin peptide after 20 mins by AlphaLISA


ACS Med Chem Lett 4: 835-40 (2013)


Article DOI: 10.1021/ml4001485
BindingDB Entry DOI: 10.7270/Q2DV1MB8
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM50010824
PNG
(CHEMBL3264788)
Show SMILES CC1(C)CC(CC(C)(C)N1)NC(=O)c1ccc(Oc2cccc(-c3ccncn3)c2C#N)c(Cl)c1
Show InChI InChI=1S/C27H28ClN5O2/c1-26(2)13-18(14-27(3,4)33-26)32-25(34)17-8-9-24(21(28)12-17)35-23-7-5-6-19(20(23)15-29)22-10-11-30-16-31-22/h5-12,16,18,33H,13-14H2,1-4H3,(H,32,34)
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n/an/a 24n/an/an/an/an/an/a



Constellation Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of wild type EZH2 (unknown origin)


ACS Med Chem Lett 5: 378-83 (2014)


Article DOI: 10.1021/ml400494b
BindingDB Entry DOI: 10.7270/Q2BP04BR
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM50440727
PNG
(CHEMBL2431090)
Show SMILES Cc1noc2[C@H](CC(N)=O)N=C(c3c(C)c(C)sc3-c12)c1ccc(Cl)cc1
Show InChI InChI=1/C20H18ClN3O2S/c1-9-11(3)27-20-16(9)18(12-4-6-13(21)7-5-12)23-14(8-15(22)25)19-17(20)10(2)24-26-19/h4-7,14H,8H2,1-3H3,(H2,22,25)/t14-/s2
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n/an/a 26n/an/an/an/an/an/a



Constellation Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of His-FLAG-tagged BRD4 binding domain1 (unknown origin) binding to H4-TetraAc-biotin peptide after 20 mins by AlphaLISA


ACS Med Chem Lett 4: 835-40 (2013)


Article DOI: 10.1021/ml4001485
BindingDB Entry DOI: 10.7270/Q2DV1MB8
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM50440718
PNG
(CHEMBL2431078)
Show SMILES Cc1noc2[C@H](CC(N)=O)N=C(c3c(C)c(C)sc3-c12)c1ccccc1
Show InChI InChI=1/C20H19N3O2S/c1-10-12(3)26-20-16(10)18(13-7-5-4-6-8-13)22-14(9-15(21)24)19-17(20)11(2)23-25-19/h4-8,14H,9H2,1-3H3,(H2,21,24)/t14-/s2
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n/an/a 29n/an/an/an/an/an/a



Constellation Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of His-FLAG-tagged BRD4 binding domain1 (unknown origin) binding to H4-TetraAc-biotin peptide after 20 mins by AlphaLISA


ACS Med Chem Lett 4: 835-40 (2013)


Article DOI: 10.1021/ml4001485
BindingDB Entry DOI: 10.7270/Q2DV1MB8
More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50178219
PNG
(CHEMBL3814752)
Show SMILES C[C@@H]1CC(=O)Nc2cccc(-c3ccc4n(C)nc(-c5cnn(C)c5)c4c3)c2N1
Show InChI InChI=1/C22H22N6O/c1-13-9-20(29)25-18-6-4-5-16(22(18)24-13)14-7-8-19-17(10-14)21(26-28(19)3)15-11-23-27(2)12-15/h4-8,10-13,24H,9H2,1-3H3,(H,25,29)/t13-/s2
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n/an/a 30n/an/an/an/an/an/a



Constellation Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of biotinylated ligand from recombinant His-tagged CBP (unknown origin) incubated for 10 mins by TR-FRET assay


ACS Med Chem Lett 7: 531-6 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00075
BindingDB Entry DOI: 10.7270/Q20G3N3S
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM50010823
PNG
(CHEMBL3264787)
Show SMILES CC1(C)CC(CC(C)(C)N1)NC(=O)c1ccc(Oc2cccc(-c3ccnnc3)c2C#N)c(Cl)c1
Show InChI InChI=1S/C27H28ClN5O2/c1-26(2)13-19(14-27(3,4)33-26)32-25(34)17-8-9-24(22(28)12-17)35-23-7-5-6-20(21(23)15-29)18-10-11-30-31-16-18/h5-12,16,19,33H,13-14H2,1-4H3,(H,32,34)
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n/an/a 32n/an/an/an/an/an/a



Constellation Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of wild type EZH2 (unknown origin)


ACS Med Chem Lett 5: 378-83 (2014)


Article DOI: 10.1021/ml400494b
BindingDB Entry DOI: 10.7270/Q2BP04BR
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM50440717
PNG
(CHEMBL2431079)
Show SMILES Cc1noc2[C@H](CC(N)=O)N=C(c3c(C)c(C)sc3-c12)c1ccc(cc1)C#N
Show InChI InChI=1/C21H18N4O2S/c1-10-12(3)28-21-17(10)19(14-6-4-13(9-22)5-7-14)24-15(8-16(23)26)20-18(21)11(2)25-27-20/h4-7,15H,8H2,1-3H3,(H2,23,26)/t15-/s2
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Constellation Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of His-FLAG-tagged BRD4 binding domain1 (unknown origin) binding to H4-TetraAc-biotin peptide after 20 mins by AlphaLISA


ACS Med Chem Lett 4: 835-40 (2013)


Article DOI: 10.1021/ml4001485
BindingDB Entry DOI: 10.7270/Q2DV1MB8
More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50178220
PNG
(CHEMBL3814550 | US10206931, Example 57)
Show SMILES C[C@@H]1CC(=O)Nc2cccc(-c3ccc4n(C)nc(C5CC5)c4c3)c2N1
Show InChI InChI=1/C21H22N4O/c1-12-10-19(26)23-17-5-3-4-15(21(17)22-12)14-8-9-18-16(11-14)20(13-6-7-13)24-25(18)2/h3-5,8-9,11-13,22H,6-7,10H2,1-2H3,(H,23,26)/t12-/s2
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Constellation Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of biotinylated ligand from recombinant His-tagged CBP (unknown origin) incubated for 10 mins by TR-FRET assay


ACS Med Chem Lett 7: 531-6 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00075
BindingDB Entry DOI: 10.7270/Q20G3N3S
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM50440726
PNG
(CHEMBL2431091)
Show SMILES CCNC(=O)C[C@@H]1N=C(c2c(C)c(C)sc2-c2c(C)noc12)c1ccc(Cl)cc1
Show InChI InChI=1/C22H22ClN3O2S/c1-5-24-17(27)10-16-21-19(12(3)26-28-21)22-18(11(2)13(4)29-22)20(25-16)14-6-8-15(23)9-7-14/h6-9,16H,5,10H2,1-4H3,(H,24,27)/t16-/s2
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Constellation Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of His-FLAG-tagged BRD4 binding domain1 (unknown origin) binding to H4-TetraAc-biotin peptide after 20 mins by AlphaLISA


ACS Med Chem Lett 4: 835-40 (2013)


Article DOI: 10.1021/ml4001485
BindingDB Entry DOI: 10.7270/Q2DV1MB8
More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50178169
PNG
(CHEMBL3814896 | US10206931, Example 75)
Show SMILES C[C@@H]1CC(=O)Nc2cccc(C(=O)Nc3cccc(c3)-c3cnco3)c2N1
Show InChI InChI=1/C20H18N4O3/c1-12-8-18(25)24-16-7-3-6-15(19(16)22-12)20(26)23-14-5-2-4-13(9-14)17-10-21-11-27-17/h2-7,9-12,22H,8H2,1H3,(H,23,26)(H,24,25)/t12-/s2
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Constellation Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of biotinylated ligand from recombinant His-tagged CBP (unknown origin) incubated for 10 mins by TR-FRET assay


ACS Med Chem Lett 7: 531-6 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00075
BindingDB Entry DOI: 10.7270/Q20G3N3S
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM50440716
PNG
(CHEMBL2431080)
Show SMILES Cc1noc2[C@H](CC(N)=O)N=C(c3c(C)c(C)sc3-c12)c1ccc(Cl)cc1C
Show InChI InChI=1/C21H20ClN3O2S/c1-9-7-13(22)5-6-14(9)19-17-10(2)12(4)28-21(17)18-11(3)25-27-20(18)15(24-19)8-16(23)26/h5-7,15H,8H2,1-4H3,(H2,23,26)/t15-/s2
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Constellation Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of His-FLAG-tagged BRD4 binding domain1 (unknown origin) binding to H4-TetraAc-biotin peptide after 20 mins by AlphaLISA


ACS Med Chem Lett 4: 835-40 (2013)


Article DOI: 10.1021/ml4001485
BindingDB Entry DOI: 10.7270/Q2DV1MB8
More data for this
Ligand-Target Pair
Histone acetyltransferase p300


(Homo sapiens (Human))
BDBM50178219
PNG
(CHEMBL3814752)
Show SMILES C[C@@H]1CC(=O)Nc2cccc(-c3ccc4n(C)nc(-c5cnn(C)c5)c4c3)c2N1
Show InChI InChI=1/C22H22N6O/c1-13-9-20(29)25-18-6-4-5-16(22(18)24-13)14-7-8-19-17(10-14)21(26-28(19)3)15-11-23-27(2)12-15/h4-8,10-13,24H,9H2,1-3H3,(H,25,29)/t13-/s2
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Constellation Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of biotinylated ligand from recombinant His-tagged EP300 (unknown origin) incubated for 10 mins by TR-FRET assay


ACS Med Chem Lett 7: 531-6 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00075
BindingDB Entry DOI: 10.7270/Q20G3N3S
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM50365262
PNG
( (S)-JQ1 (1) | CHEMBL1957266 | JQ1 | US10124009, C...)
Show SMILES Cc1nnc2[C@H](CC(=O)OC(C)(C)C)N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1
Show InChI InChI=1/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15)25-17(11-18(29)30-23(4,5)6)21-27-26-14(3)28(21)22/h7-10,17H,11H2,1-6H3/t17-/s2
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Constellation Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of BRD4 in human Raji cells assessed as reduction of MYC expression after 4 hrs


ACS Med Chem Lett 4: 835-40 (2013)


Article DOI: 10.1021/ml4001485
BindingDB Entry DOI: 10.7270/Q2DV1MB8
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM50440715
PNG
(CHEMBL2431081)
Show SMILES Cc1noc2[C@H](CC(N)=O)N=C(c3c(C)c(C)sc3-c12)c1ccc(Cl)cn1
Show InChI InChI=1/C19H17ClN4O2S/c1-8-10(3)27-19-15(8)17(12-5-4-11(20)7-22-12)23-13(6-14(21)25)18-16(19)9(2)24-26-18/h4-5,7,13H,6H2,1-3H3,(H2,21,25)/t13-/s2
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Constellation Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of His-FLAG-tagged BRD4 binding domain1 (unknown origin) binding to H4-TetraAc-biotin peptide after 20 mins by AlphaLISA


ACS Med Chem Lett 4: 835-40 (2013)


Article DOI: 10.1021/ml4001485
BindingDB Entry DOI: 10.7270/Q2DV1MB8
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM50440734
PNG
(CHEMBL2431082)
Show SMILES Cc1noc2[C@H](CC(N)=O)N=C(c3c(C)c(C)sc3-c12)c1ccc(N)nc1
Show InChI InChI=1/C19H19N5O2S/c1-8-10(3)27-19-15(8)17(11-4-5-13(20)22-7-11)23-12(6-14(21)25)18-16(19)9(2)24-26-18/h4-5,7,12H,6H2,1-3H3,(H2,20,22)(H2,21,25)/t12-/s2
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Constellation Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of His-FLAG-tagged BRD4 binding domain1 (unknown origin) binding to H4-TetraAc-biotin peptide after 20 mins by AlphaLISA


ACS Med Chem Lett 4: 835-40 (2013)


Article DOI: 10.1021/ml4001485
BindingDB Entry DOI: 10.7270/Q2DV1MB8
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM50440720
PNG
(CHEMBL2431076)
Show SMILES Cc1noc2[C@H](CC(N)=O)N=C(c3c(C)c(C)sc3-c12)c1cccc(Cl)c1
Show InChI InChI=1/C20H18ClN3O2S/c1-9-11(3)27-20-16(9)18(12-5-4-6-13(21)7-12)23-14(8-15(22)25)19-17(20)10(2)24-26-19/h4-7,14H,8H2,1-3H3,(H2,22,25)/t14-/s2
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Constellation Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of His-FLAG-tagged BRD4 binding domain1 (unknown origin) binding to H4-TetraAc-biotin peptide after 20 mins by AlphaLISA


ACS Med Chem Lett 4: 835-40 (2013)


Article DOI: 10.1021/ml4001485
BindingDB Entry DOI: 10.7270/Q2DV1MB8
More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50178161
PNG
(CHEMBL3813929)
Show SMILES C[C@@H]1CC(=O)Nc2cccc(-c3ccc4n(C)nc(C(N)=O)c4c3)c2N1
Show InChI InChI=1/C19H19N5O2/c1-10-8-16(25)22-14-5-3-4-12(17(14)21-10)11-6-7-15-13(9-11)18(19(20)26)23-24(15)2/h3-7,9-10,21H,8H2,1-2H3,(H2,20,26)(H,22,25)/t10-/s2
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Constellation Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of biotinylated ligand from recombinant His-tagged CBP (unknown origin) incubated for 10 mins by TR-FRET assay


ACS Med Chem Lett 7: 531-6 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00075
BindingDB Entry DOI: 10.7270/Q20G3N3S
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM50010822
PNG
(CHEMBL3264786)
Show SMILES CC1(C)CC(CC(C)(C)N1)NC(=O)c1ccc(Oc2cccc(-c3ccncc3)c2C#N)c(Cl)c1
Show InChI InChI=1S/C28H29ClN4O2/c1-27(2)15-20(16-28(3,4)33-27)32-26(34)19-8-9-25(23(29)14-19)35-24-7-5-6-21(22(24)17-30)18-10-12-31-13-11-18/h5-14,20,33H,15-16H2,1-4H3,(H,32,34)
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Constellation Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of wild type EZH2 (unknown origin)


ACS Med Chem Lett 5: 378-83 (2014)


Article DOI: 10.1021/ml400494b
BindingDB Entry DOI: 10.7270/Q2BP04BR
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM50440725
PNG
(CHEMBL2431093)
Show SMILES COC(=O)NC[C@@H]1N=C(c2c(C)c(C)sc2-c2c(C)noc12)c1ccc(Cl)cc1
Show InChI InChI=1/C21H20ClN3O3S/c1-10-12(3)29-20-16(10)18(13-5-7-14(22)8-6-13)24-15(9-23-21(26)27-4)19-17(20)11(2)25-28-19/h5-8,15H,9H2,1-4H3,(H,23,26)/t15-/s2
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Constellation Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of His-FLAG-tagged BRD4 binding domain1 (unknown origin) binding to H4-TetraAc-biotin peptide after 20 mins by AlphaLISA


ACS Med Chem Lett 4: 835-40 (2013)


Article DOI: 10.1021/ml4001485
BindingDB Entry DOI: 10.7270/Q2DV1MB8
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM50440717
PNG
(CHEMBL2431079)
Show SMILES Cc1noc2[C@H](CC(N)=O)N=C(c3c(C)c(C)sc3-c12)c1ccc(cc1)C#N
Show InChI InChI=1/C21H18N4O2S/c1-10-12(3)28-21-17(10)19(14-6-4-13(9-22)5-7-14)24-15(8-16(23)26)20-18(21)11(2)25-27-20/h4-7,15H,8H2,1-3H3,(H2,23,26)/t15-/s2
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Constellation Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of BRD4 in human Raji cells assessed as reduction of MYC expression after 4 hrs


ACS Med Chem Lett 4: 835-40 (2013)


Article DOI: 10.1021/ml4001485
BindingDB Entry DOI: 10.7270/Q2DV1MB8
More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50178163
PNG
(CHEMBL3813846 | US10206931, Example 286)
Show SMILES C[C@@H]1CC(=O)Nc2cccc(-c3cccc(OCc4ccccc4)c3)c2N1
Show InChI InChI=1/C23H22N2O2/c1-16-13-22(26)25-21-12-6-11-20(23(21)24-16)18-9-5-10-19(14-18)27-15-17-7-3-2-4-8-17/h2-12,14,16,24H,13,15H2,1H3,(H,25,26)/t16-/s2
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Constellation Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of biotinylated ligand from recombinant His-tagged CBP (unknown origin) incubated for 10 mins by TR-FRET assay


ACS Med Chem Lett 7: 531-6 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00075
BindingDB Entry DOI: 10.7270/Q20G3N3S
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM50365463
PNG
(CHEMBL1232461)
Show SMILES CCNC(=O)C[C@@H]1N=C(c2ccc(Cl)cc2)c2cc(OC)ccc2-n2c(C)nnc12
Show InChI InChI=1/C22H22ClN5O2/c1-4-24-20(29)12-18-22-27-26-13(2)28(22)19-10-9-16(30-3)11-17(19)21(25-18)14-5-7-15(23)8-6-14/h5-11,18H,4,12H2,1-3H3,(H,24,29)/t18-/s2
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Constellation Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of His-FLAG-tagged BRD4 binding domain1 (unknown origin) binding to H4-TetraAc-biotin peptide after 20 mins by AlphaLISA


ACS Med Chem Lett 4: 835-40 (2013)


Article DOI: 10.1021/ml4001485
BindingDB Entry DOI: 10.7270/Q2DV1MB8
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
CREB-binding protein


(Homo sapiens (Human))
BDBM50178168
PNG
(CHEMBL3814246 | US10206931, Example 176)
Show SMILES COc1ccc(cc1OC)-c1cccc2NC(=O)C[C@@H](C)Nc12
Show InChI InChI=1/C18H20N2O3/c1-11-9-17(21)20-14-6-4-5-13(18(14)19-11)12-7-8-15(22-2)16(10-12)23-3/h4-8,10-11,19H,9H2,1-3H3,(H,20,21)/t11-/s2
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Constellation Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of biotinylated ligand from recombinant His-tagged CBP (unknown origin) incubated for 10 mins by TR-FRET assay


ACS Med Chem Lett 7: 531-6 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00075
BindingDB Entry DOI: 10.7270/Q20G3N3S
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM50380682
PNG
(CHEMBL2017291 | I-BET151 (16))
Show SMILES COc1cc2c3n([C@H](C)c4ccccn4)c(=O)[nH]c3cnc2cc1-c1c(C)noc1C
Show InChI InChI=1/C23H21N5O3/c1-12-21(14(3)31-27-12)16-9-18-15(10-20(16)30-4)22-19(11-25-18)26-23(29)28(22)13(2)17-7-5-6-8-24-17/h5-11,13H,1-4H3,(H,26,29)/t13-/s2
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Constellation Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of BRD4 in human Raji cells assessed as reduction of MYC expression after 4 hrs


ACS Med Chem Lett 4: 835-40 (2013)


Article DOI: 10.1021/ml4001485
BindingDB Entry DOI: 10.7270/Q2DV1MB8
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM50440727
PNG
(CHEMBL2431090)
Show SMILES Cc1noc2[C@H](CC(N)=O)N=C(c3c(C)c(C)sc3-c12)c1ccc(Cl)cc1
Show InChI InChI=1/C20H18ClN3O2S/c1-9-11(3)27-20-16(9)18(12-4-6-13(21)7-5-12)23-14(8-15(22)25)19-17(20)10(2)24-26-19/h4-7,14H,8H2,1-3H3,(H2,22,25)/t14-/s2
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Constellation Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of BRD4 in human Raji cells assessed as reduction of MYC expression after 4 hrs


ACS Med Chem Lett 4: 835-40 (2013)


Article DOI: 10.1021/ml4001485
BindingDB Entry DOI: 10.7270/Q2DV1MB8
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM50010820
PNG
(CHEMBL3264784)
Show SMILES CC1(C)CC(CC(C)(C)N1)NC(=O)c1ccc(Oc2cccc(Cl)c2C#N)c(Cl)c1
Show InChI InChI=1S/C23H25Cl2N3O2/c1-22(2)11-15(12-23(3,4)28-22)27-21(29)14-8-9-20(18(25)10-14)30-19-7-5-6-17(24)16(19)13-26/h5-10,15,28H,11-12H2,1-4H3,(H,27,29)
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Constellation Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of wild type EZH2 (unknown origin)


ACS Med Chem Lett 5: 378-83 (2014)


Article DOI: 10.1021/ml400494b
BindingDB Entry DOI: 10.7270/Q2BP04BR
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM50010819
PNG
(CHEMBL3264783)
Show SMILES Cc1cccc(Oc2ccc(cc2Cl)C(=O)NC2CC(C)(C)NC(C)(C)C2)c1C#N
Show InChI InChI=1S/C24H28ClN3O2/c1-15-7-6-8-20(18(15)14-26)30-21-10-9-16(11-19(21)25)22(29)27-17-12-23(2,3)28-24(4,5)13-17/h6-11,17,28H,12-13H2,1-5H3,(H,27,29)
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Constellation Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of wild type EZH2 (unknown origin)


ACS Med Chem Lett 5: 378-83 (2014)


Article DOI: 10.1021/ml400494b
BindingDB Entry DOI: 10.7270/Q2BP04BR
More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50178164
PNG
(CHEMBL3815023 | US10206931, Example 173)
Show SMILES CC(c1ccccc1)n1cc(cn1)-c1cccc2NC(=O)C[C@@H](C)Nc12
Show InChI InChI=1/C21H22N4O/c1-14-11-20(26)24-19-10-6-9-18(21(19)23-14)17-12-22-25(13-17)15(2)16-7-4-3-5-8-16/h3-10,12-15,23H,11H2,1-2H3,(H,24,26)/t14-,15?/s2
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Constellation Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of biotinylated ligand from recombinant His-tagged CBP (unknown origin) incubated for 10 mins by TR-FRET assay


ACS Med Chem Lett 7: 531-6 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00075
BindingDB Entry DOI: 10.7270/Q20G3N3S
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM50440716
PNG
(CHEMBL2431080)
Show SMILES Cc1noc2[C@H](CC(N)=O)N=C(c3c(C)c(C)sc3-c12)c1ccc(Cl)cc1C
Show InChI InChI=1/C21H20ClN3O2S/c1-9-7-13(22)5-6-14(9)19-17-10(2)12(4)28-21(17)18-11(3)25-27-20(18)15(24-19)8-16(23)26/h5-7,15H,8H2,1-4H3,(H2,23,26)/t15-/s2
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Constellation Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of BRD4 in human Raji cells assessed as reduction of MYC expression after 4 hrs


ACS Med Chem Lett 4: 835-40 (2013)


Article DOI: 10.1021/ml4001485
BindingDB Entry DOI: 10.7270/Q2DV1MB8
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM50010835
PNG
(CHEMBL3264794)
Show SMILES CC1(C)CC(CC(C)(C)N1)OC(=O)c1ccc(Oc2cccc(-c3ccnnc3)c2C#N)c(Cl)c1
Show InChI InChI=1S/C27H27ClN4O3/c1-26(2)13-19(14-27(3,4)32-26)34-25(33)17-8-9-24(22(28)12-17)35-23-7-5-6-20(21(23)15-29)18-10-11-30-31-16-18/h5-12,16,19,32H,13-14H2,1-4H3
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Constellation Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of wild type EZH2 (unknown origin)


ACS Med Chem Lett 5: 378-83 (2014)


Article DOI: 10.1021/ml400494b
BindingDB Entry DOI: 10.7270/Q2BP04BR
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM50440718
PNG
(CHEMBL2431078)
Show SMILES Cc1noc2[C@H](CC(N)=O)N=C(c3c(C)c(C)sc3-c12)c1ccccc1
Show InChI InChI=1/C20H19N3O2S/c1-10-12(3)26-20-16(10)18(13-7-5-4-6-8-13)22-14(9-15(21)24)19-17(20)11(2)23-25-19/h4-8,14H,9H2,1-3H3,(H2,21,24)/t14-/s2
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Constellation Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of BRD4 in human Raji cells assessed as reduction of MYC expression after 4 hrs


ACS Med Chem Lett 4: 835-40 (2013)


Article DOI: 10.1021/ml4001485
BindingDB Entry DOI: 10.7270/Q2DV1MB8
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM50010836
PNG
(CHEMBL3264795)
Show SMILES CC1(C)CC(COc2ccc(Oc3cccc(-c4ccncn4)c3C#N)c(Cl)c2)CC(C)(C)N1
Show InChI InChI=1S/C27H29ClN4O2/c1-26(2)13-18(14-27(3,4)32-26)16-33-19-8-9-25(22(28)12-19)34-24-7-5-6-20(21(24)15-29)23-10-11-30-17-31-23/h5-12,17-18,32H,13-14,16H2,1-4H3
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Constellation Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of wild type EZH2 (unknown origin)


ACS Med Chem Lett 5: 378-83 (2014)


Article DOI: 10.1021/ml400494b
BindingDB Entry DOI: 10.7270/Q2BP04BR
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM50365463
PNG
(CHEMBL1232461)
Show SMILES CCNC(=O)C[C@@H]1N=C(c2ccc(Cl)cc2)c2cc(OC)ccc2-n2c(C)nnc12
Show InChI InChI=1/C22H22ClN5O2/c1-4-24-20(29)12-18-22-27-26-13(2)28(22)19-10-9-16(30-3)11-17(19)21(25-18)14-5-7-15(23)8-6-14/h5-11,18H,4,12H2,1-3H3,(H,24,29)/t18-/s2
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Constellation Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of BRD4 in human Raji cells assessed as reduction of MYC expression after 4 hrs


ACS Med Chem Lett 4: 835-40 (2013)


Article DOI: 10.1021/ml4001485
BindingDB Entry DOI: 10.7270/Q2DV1MB8
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM50440724
PNG
(CHEMBL2431094)
Show SMILES CC(=O)NC[C@@H]1N=C(c2c(C)c(C)sc2-c2c(C)noc12)c1ccc(Cl)cc1
Show InChI InChI=1/C21H20ClN3O2S/c1-10-12(3)28-21-17(10)19(14-5-7-15(22)8-6-14)24-16(9-23-13(4)26)20-18(21)11(2)25-27-20/h5-8,16H,9H2,1-4H3,(H,23,26)/t16-/s2
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Constellation Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of His-FLAG-tagged BRD4 binding domain1 (unknown origin) binding to H4-TetraAc-biotin peptide after 20 mins by AlphaLISA


ACS Med Chem Lett 4: 835-40 (2013)


Article DOI: 10.1021/ml4001485
BindingDB Entry DOI: 10.7270/Q2DV1MB8
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM50440722
PNG
(CHEMBL2431074)
Show SMILES Cc1noc2[C@H](Cc3nccs3)N=C(c3c(C)c(C)sc3-c12)c1ccc(Cl)cc1
Show InChI InChI=1/C22H18ClN3OS2/c1-11-13(3)29-22-18(11)20(14-4-6-15(23)7-5-14)25-16(10-17-24-8-9-28-17)21-19(22)12(2)26-27-21/h4-9,16H,10H2,1-3H3/t16-/s2
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Constellation Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of His-FLAG-tagged BRD4 binding domain1 (unknown origin) binding to H4-TetraAc-biotin peptide after 20 mins by AlphaLISA


ACS Med Chem Lett 4: 835-40 (2013)


Article DOI: 10.1021/ml4001485
BindingDB Entry DOI: 10.7270/Q2DV1MB8
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM50440723
PNG
(CHEMBL2431073)
Show SMILES Cc1noc2[C@H](Cc3ncc[nH]3)N=C(c3c(C)c(C)sc3-c12)c1ccc(Cl)cc1
Show InChI InChI=1/C22H19ClN4OS/c1-11-13(3)29-22-18(11)20(14-4-6-15(23)7-5-14)26-16(10-17-24-8-9-25-17)21-19(22)12(2)27-28-21/h4-9,16H,10H2,1-3H3,(H,24,25)/t16-/s2
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Constellation Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of His-FLAG-tagged BRD4 binding domain1 (unknown origin) binding to H4-TetraAc-biotin peptide after 20 mins by AlphaLISA


ACS Med Chem Lett 4: 835-40 (2013)


Article DOI: 10.1021/ml4001485
BindingDB Entry DOI: 10.7270/Q2DV1MB8
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM50010821
PNG
(CHEMBL3264785)
Show SMILES CC1(C)CC(CC(C)(C)N1)NC(=O)c1ccc(Oc2cccc(-c3cn[nH]c3)c2C#N)c(Cl)c1
Show InChI InChI=1S/C26H28ClN5O2/c1-25(2)11-18(12-26(3,4)32-25)31-24(33)16-8-9-23(21(27)10-16)34-22-7-5-6-19(20(22)13-28)17-14-29-30-15-17/h5-10,14-15,18,32H,11-12H2,1-4H3,(H,29,30)(H,31,33)
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Constellation Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of wild type EZH2 (unknown origin)


ACS Med Chem Lett 5: 378-83 (2014)


Article DOI: 10.1021/ml400494b
BindingDB Entry DOI: 10.7270/Q2BP04BR
More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50178162
PNG
(CHEMBL3814197)
Show SMILES C[C@@H]1CC(=O)Nc2cccc(-c3ccc4n(C)ncc4c3)c2N1
Show InChI InChI=1/C18H18N4O/c1-11-8-17(23)21-15-5-3-4-14(18(15)20-11)12-6-7-16-13(9-12)10-19-22(16)2/h3-7,9-11,20H,8H2,1-2H3,(H,21,23)/t11-/s2
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Constellation Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of biotinylated ligand from recombinant His-tagged CBP (unknown origin) incubated for 10 mins by TR-FRET assay


ACS Med Chem Lett 7: 531-6 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00075
BindingDB Entry DOI: 10.7270/Q20G3N3S
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM50440715
PNG
(CHEMBL2431081)
Show SMILES Cc1noc2[C@H](CC(N)=O)N=C(c3c(C)c(C)sc3-c12)c1ccc(Cl)cn1
Show InChI InChI=1/C19H17ClN4O2S/c1-8-10(3)27-19-15(8)17(12-5-4-11(20)7-22-12)23-13(6-14(21)25)18-16(19)9(2)24-26-18/h4-5,7,13H,6H2,1-3H3,(H2,21,25)/t13-/s2
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n/an/a 240n/an/an/an/an/an/a



Constellation Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of BRD4 in human Raji cells assessed as reduction of MYC expression after 4 hrs


ACS Med Chem Lett 4: 835-40 (2013)


Article DOI: 10.1021/ml4001485
BindingDB Entry DOI: 10.7270/Q2DV1MB8
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM50440721
PNG
(CHEMBL2431075)
Show SMILES C[C@H]([C@@H]1N=C(c2c(C)c(C)sc2-c2c(C)noc12)c1ccc(cc1)C#N)C(N)=O
Show InChI InChI=1/C22H20N4O2S/c1-10-13(4)29-21-16(10)19(15-7-5-14(9-23)6-8-15)25-18(11(2)22(24)27)20-17(21)12(3)26-28-20/h5-8,11,18H,1-4H3,(H2,24,27)/t11-,18+/s2
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Constellation Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of His-FLAG-tagged BRD4 binding domain1 (unknown origin) binding to H4-TetraAc-biotin peptide after 20 mins by AlphaLISA


ACS Med Chem Lett 4: 835-40 (2013)


Article DOI: 10.1021/ml4001485
BindingDB Entry DOI: 10.7270/Q2DV1MB8
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM50440719
PNG
(CHEMBL2431077)
Show SMILES Cc1noc2[C@H](CC(N)=O)N=C(c3c(C)c(C)sc3-c12)c1ccccc1Cl
Show InChI InChI=1/C20H18ClN3O2S/c1-9-11(3)27-20-16(9)18(12-6-4-5-7-13(12)21)23-14(8-15(22)25)19-17(20)10(2)24-26-19/h4-7,14H,8H2,1-3H3,(H2,22,25)/t14-/s2
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Constellation Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of His-FLAG-tagged BRD4 binding domain1 (unknown origin) binding to H4-TetraAc-biotin peptide after 20 mins by AlphaLISA


ACS Med Chem Lett 4: 835-40 (2013)


Article DOI: 10.1021/ml4001485
BindingDB Entry DOI: 10.7270/Q2DV1MB8
More data for this
Ligand-Target Pair
CREB-binding protein


(Homo sapiens (Human))
BDBM50178221
PNG
(CHEMBL3814602)
Show SMILES C[C@@H]1CC(=O)Nc2cccc(-c3ccc4n(C)nc(C#N)c4c3)c2N1
Show InChI InChI=1/C19H17N5O/c1-11-8-18(25)22-15-5-3-4-13(19(15)21-11)12-6-7-17-14(9-12)16(10-20)23-24(17)2/h3-7,9,11,21H,8H2,1-2H3,(H,22,25)/t11-/s2
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Constellation Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of biotinylated ligand from recombinant His-tagged CBP (unknown origin) incubated for 10 mins by TR-FRET assay


ACS Med Chem Lett 7: 531-6 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00075
BindingDB Entry DOI: 10.7270/Q20G3N3S
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM50440728
PNG
(CHEMBL2431089)
Show SMILES Cc1noc2[C@H](CC(=O)OC(C)(C)C)N=C(c3c(C)c(C)sc3-c12)c1ccc(Cl)cc1
Show InChI InChI=1/C24H25ClN2O3S/c1-12-14(3)31-23-19(12)21(15-7-9-16(25)10-8-15)26-17(11-18(28)29-24(4,5)6)22-20(23)13(2)27-30-22/h7-10,17H,11H2,1-6H3/t17-/s2
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Constellation Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of His-FLAG-tagged BRD4 binding domain1 (unknown origin) binding to H4-TetraAc-biotin peptide after 20 mins by AlphaLISA


ACS Med Chem Lett 4: 835-40 (2013)


Article DOI: 10.1021/ml4001485
BindingDB Entry DOI: 10.7270/Q2DV1MB8
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM50440731
PNG
(CHEMBL2431085)
Show SMILES CCCC1=N[C@@H](CC(N)=O)c2onc(C)c2-c2sc(C)c(C)c12
Show InChI InChI=1/C17H21N3O2S/c1-5-6-11-14-8(2)10(4)23-17(14)15-9(3)20-22-16(15)12(19-11)7-13(18)21/h12H,5-7H2,1-4H3,(H2,18,21)/t12-/s2
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Constellation Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of His-FLAG-tagged BRD4 binding domain1 (unknown origin) binding to H4-TetraAc-biotin peptide after 20 mins by AlphaLISA


ACS Med Chem Lett 4: 835-40 (2013)


Article DOI: 10.1021/ml4001485
BindingDB Entry DOI: 10.7270/Q2DV1MB8
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM50440726
PNG
(CHEMBL2431091)
Show SMILES CCNC(=O)C[C@@H]1N=C(c2c(C)c(C)sc2-c2c(C)noc12)c1ccc(Cl)cc1
Show InChI InChI=1/C22H22ClN3O2S/c1-5-24-17(27)10-16-21-19(12(3)26-28-21)22-18(11(2)13(4)29-22)20(25-16)14-6-8-15(23)9-7-14/h6-9,16H,5,10H2,1-4H3,(H,24,27)/t16-/s2
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Constellation Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of BRD4 in human Raji cells assessed as reduction of MYC expression after 4 hrs


ACS Med Chem Lett 4: 835-40 (2013)


Article DOI: 10.1021/ml4001485
BindingDB Entry DOI: 10.7270/Q2DV1MB8
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM50010816
PNG
(CHEMBL3264780)
Show SMILES CC1(C)CC(CC(C)(C)N1)NC(=O)c1ccc(Oc2ccccc2C#N)c(Br)c1
Show InChI InChI=1S/C23H26BrN3O2/c1-22(2)12-17(13-23(3,4)27-22)26-21(28)15-9-10-20(18(24)11-15)29-19-8-6-5-7-16(19)14-25/h5-11,17,27H,12-13H2,1-4H3,(H,26,28)
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Constellation Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of wild type EZH2 (unknown origin)


ACS Med Chem Lett 5: 378-83 (2014)


Article DOI: 10.1021/ml400494b
BindingDB Entry DOI: 10.7270/Q2BP04BR
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM50440734
PNG
(CHEMBL2431082)
Show SMILES Cc1noc2[C@H](CC(N)=O)N=C(c3c(C)c(C)sc3-c12)c1ccc(N)nc1
Show InChI InChI=1/C19H19N5O2S/c1-8-10(3)27-19-15(8)17(11-4-5-13(20)22-7-11)23-12(6-14(21)25)18-16(19)9(2)24-26-18/h4-5,7,12H,6H2,1-3H3,(H2,20,22)(H2,21,25)/t12-/s2
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Constellation Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of BRD4 in human Raji cells assessed as reduction of MYC expression after 4 hrs


ACS Med Chem Lett 4: 835-40 (2013)


Article DOI: 10.1021/ml4001485
BindingDB Entry DOI: 10.7270/Q2DV1MB8
More data for this
Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))
BDBM50010815
PNG
(CHEMBL3264779)
Show SMILES CC1(C)CC(CC(C)(C)N1)NC(=O)c1ccc(Oc2ccccc2C#N)c(Cl)c1
Show InChI InChI=1S/C23H26ClN3O2/c1-22(2)12-17(13-23(3,4)27-22)26-21(28)15-9-10-20(18(24)11-15)29-19-8-6-5-7-16(19)14-25/h5-11,17,27H,12-13H2,1-4H3,(H,26,28)
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Constellation Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of wild type EZH2 (unknown origin)


ACS Med Chem Lett 5: 378-83 (2014)


Article DOI: 10.1021/ml400494b
BindingDB Entry DOI: 10.7270/Q2BP04BR
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4


(Homo sapiens (Human))
BDBM50440720
PNG
(CHEMBL2431076)
Show SMILES Cc1noc2[C@H](CC(N)=O)N=C(c3c(C)c(C)sc3-c12)c1cccc(Cl)c1
Show InChI InChI=1/C20H18ClN3O2S/c1-9-11(3)27-20-16(9)18(12-5-4-6-13(21)7-12)23-14(8-15(22)25)19-17(20)10(2)24-26-19/h4-7,14H,8H2,1-3H3,(H2,22,25)/t14-/s2
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Constellation Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of BRD4 in human Raji cells assessed as reduction of MYC expression after 4 hrs


ACS Med Chem Lett 4: 835-40 (2013)


Article DOI: 10.1021/ml4001485
BindingDB Entry DOI: 10.7270/Q2DV1MB8
More data for this
Ligand-Target Pair
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