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Compile Data Set for Download or QSAR

Found 390 hits from Corcept Therapeutics   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50265728
PNG
(CHEMBL4081121)
Show SMILES Cc1cccc(c1)S(=O)(=O)N1CCC2=Cc3c(C[C@@]2(C1)C(=O)c1cc(C)ccn1)cnn3-c1ccc(F)cc1
Show InChI InChI=1S/C30H27FN4O3S/c1-20-4-3-5-26(14-20)39(37,38)34-13-11-23-16-28-22(18-33-35(28)25-8-6-24(31)7-9-25)17-30(23,19-34)29(36)27-15-21(2)10-12-32-27/h3-10,12,14-16,18H,11,13,17,19H2,1-2H3/t30-/m0/s1
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0.0800n/an/an/an/an/an/an/an/a



Corcept Therapeutics

Curated by ChEMBL


Assay Description
Displacement of fluormone GS Red from human glucocorticoid receptor after 4 hrs by fluorescence polarization assay


J Med Chem 60: 3405-3421 (2017)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM18627
PNG
((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Show SMILES CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(cc1)N(C)C
Show InChI InChI=1/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/s2
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PubMed
0.0900n/an/an/an/an/an/an/an/a



Corcept Therapeutics

Curated by ChEMBL


Assay Description
Displacement of fluormone GS Red from human glucocorticoid receptor after 4 hrs by fluorescence polarization assay


J Med Chem 60: 3405-3421 (2017)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50265798
PNG
(CHEMBL3736358)
Show SMILES Fc1ccc(cc1)-n1ncc2C[C@@]3(CN(CCC3=Cc12)S(=O)(=O)c1cccc(c1)C(F)(F)F)C(=O)c1ccccn1
Show InChI InChI=1S/C29H22F4N4O3S/c30-22-7-9-23(10-8-22)37-26-15-20-11-13-36(41(39,40)24-5-3-4-21(14-24)29(31,32)33)18-28(20,16-19(26)17-35-37)27(38)25-6-1-2-12-34-25/h1-10,12,14-15,17H,11,13,16,18H2/t28-/m0/s1
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0.100n/an/an/an/an/an/an/an/a



Corcept Therapeutics

Curated by ChEMBL


Assay Description
Displacement of fluormone GS Red from human glucocorticoid receptor after 4 hrs by fluorescence polarization assay


J Med Chem 60: 3405-3421 (2017)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50265798
PNG
(CHEMBL3736358)
Show SMILES Fc1ccc(cc1)-n1ncc2C[C@@]3(CN(CCC3=Cc12)S(=O)(=O)c1cccc(c1)C(F)(F)F)C(=O)c1ccccn1
Show InChI InChI=1S/C29H22F4N4O3S/c30-22-7-9-23(10-8-22)37-26-15-20-11-13-36(41(39,40)24-5-3-4-21(14-24)29(31,32)33)18-28(20,16-19(26)17-35-37)27(38)25-6-1-2-12-34-25/h1-10,12,14-15,17H,11,13,16,18H2/t28-/m0/s1
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0.100n/an/an/an/an/an/an/an/a



Corcept Therapeutics

Curated by ChEMBL


Assay Description
Binding affinity to human recombinant glucocorticoid receptor by fluorescence polarization assay


Bioorg Med Chem Lett 25: 5720-5 (2015)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50265797
PNG
(CHEMBL4088286)
Show SMILES Fc1ccc(cc1)-n1ncc2C[C@@]3(CN(CCC3=Cc12)S(=O)(=O)c1cc(F)cc(F)c1)C(=O)c1ccccn1
Show InChI InChI=1S/C28H21F3N4O3S/c29-20-4-6-23(7-5-20)35-26-11-19-8-10-34(39(37,38)24-13-21(30)12-22(31)14-24)17-28(19,15-18(26)16-33-35)27(36)25-3-1-2-9-32-25/h1-7,9,11-14,16H,8,10,15,17H2/t28-/m0/s1
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0.120n/an/an/an/an/an/an/an/a



Corcept Therapeutics

Curated by ChEMBL


Assay Description
Displacement of fluormone GS Red from human glucocorticoid receptor after 4 hrs by fluorescence polarization assay


J Med Chem 60: 3405-3421 (2017)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50499246
PNG
(CHEMBL3735376)
Show SMILES Fc1ccc(cc1)-n1ncc2C[C@@]3(CN(CCC3=Cc12)S(=O)(=O)c1ccc(F)cc1)C(=O)c1ccccn1
Show InChI InChI=1S/C28H22F2N4O3S/c29-21-4-8-23(9-5-21)34-26-15-20-12-14-33(38(36,37)24-10-6-22(30)7-11-24)18-28(20,16-19(26)17-32-34)27(35)25-3-1-2-13-31-25/h1-11,13,15,17H,12,14,16,18H2/t28-/m0/s1
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0.130n/an/an/an/an/an/an/an/a



Corcept Therapeutics

Curated by ChEMBL


Assay Description
Binding affinity to human recombinant glucocorticoid receptor by fluorescence polarization assay


Bioorg Med Chem Lett 25: 5720-5 (2015)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50265796
PNG
(CHEMBL4067017)
Show SMILES Cc1ccnc(c1)C(=O)[C@@]12CN(CCC1=Cc1c(C2)cnn1-c1ccc(F)cc1)S(=O)(=O)c1ccc(F)c(F)c1
Show InChI InChI=1S/C29H23F3N4O3S/c1-18-8-10-33-26(12-18)28(37)29-15-19-16-34-36(22-4-2-21(30)3-5-22)27(19)13-20(29)9-11-35(17-29)40(38,39)23-6-7-24(31)25(32)14-23/h2-8,10,12-14,16H,9,11,15,17H2,1H3/t29-/m0/s1
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0.140n/an/an/an/an/an/an/an/a



Corcept Therapeutics

Curated by ChEMBL


Assay Description
Displacement of fluormone GS Red from human glucocorticoid receptor after 4 hrs by fluorescence polarization assay


J Med Chem 60: 3405-3421 (2017)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50265729
PNG
(CHEMBL4105376)
Show SMILES Cc1ccc(nc1)C(=O)[C@@]12CN(CCC1=Cc1c(C2)cnn1-c1ccc(F)cc1)S(=O)(=O)c1cccc(C)c1
Show InChI InChI=1S/C30H27FN4O3S/c1-20-4-3-5-26(14-20)39(37,38)34-13-12-23-15-28-22(18-33-35(28)25-9-7-24(31)8-10-25)16-30(23,19-34)29(36)27-11-6-21(2)17-32-27/h3-11,14-15,17-18H,12-13,16,19H2,1-2H3/t30-/m0/s1
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0.140n/an/an/an/an/an/an/an/a



Corcept Therapeutics

Curated by ChEMBL


Assay Description
Displacement of fluormone GS Red from human glucocorticoid receptor after 4 hrs by fluorescence polarization assay


J Med Chem 60: 3405-3421 (2017)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50265801
PNG
(CHEMBL3735851)
Show SMILES Fc1ccc(cc1)-n1ncc2C[C@@]3(CN(CCC3=Cc12)S(=O)(=O)c1cccc(c1)C#N)C(=O)c1ccccn1
Show InChI InChI=1S/C29H22FN5O3S/c30-23-7-9-24(10-8-23)35-27-15-22-11-13-34(39(37,38)25-5-3-4-20(14-25)17-31)19-29(22,16-21(27)18-33-35)28(36)26-6-1-2-12-32-26/h1-10,12,14-15,18H,11,13,16,19H2/t29-/m0/s1
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0.140n/an/an/an/an/an/an/an/a



Corcept Therapeutics

Curated by ChEMBL


Assay Description
Displacement of fluormone GS Red from human glucocorticoid receptor after 4 hrs by fluorescence polarization assay


J Med Chem 60: 3405-3421 (2017)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50499255
PNG
(CHEMBL3735008)
Show SMILES Fc1ccc(cc1)-n1ncc2C[C@@]3(CN(CCC3=Cc12)S(=O)(=O)c1ccc(cc1)C(F)(F)F)C(=O)c1cscn1
Show InChI InChI=1S/C27H20F4N4O3S2/c28-20-3-5-21(6-4-20)35-24-11-19-9-10-34(40(37,38)22-7-1-18(2-8-22)27(29,30)31)15-26(19,12-17(24)13-33-35)25(36)23-14-39-16-32-23/h1-8,11,13-14,16H,9-10,12,15H2/t26-/m0/s1
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0.140n/an/an/an/an/an/an/an/a



Corcept Therapeutics

Curated by ChEMBL


Assay Description
Binding affinity to human recombinant glucocorticoid receptor by fluorescence polarization assay


Bioorg Med Chem Lett 25: 5720-5 (2015)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50265804
PNG
(CHEMBL3735124)
Show SMILES Cc1cccc(c1)S(=O)(=O)N1CCC2=Cc3c(C[C@@]2(C1)C(=O)c1ccccn1)cnn3-c1ccc(F)cc1
Show InChI InChI=1S/C29H25FN4O3S/c1-20-5-4-6-25(15-20)38(36,37)33-14-12-22-16-27-21(18-32-34(27)24-10-8-23(30)9-11-24)17-29(22,19-33)28(35)26-7-2-3-13-31-26/h2-11,13,15-16,18H,12,14,17,19H2,1H3/t29-/m0/s1
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0.140n/an/an/an/an/an/an/an/a



Corcept Therapeutics

Curated by ChEMBL


Assay Description
Binding affinity to human recombinant glucocorticoid receptor by fluorescence polarization assay


Bioorg Med Chem Lett 25: 5720-5 (2015)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50265801
PNG
(CHEMBL3735851)
Show SMILES Fc1ccc(cc1)-n1ncc2C[C@@]3(CN(CCC3=Cc12)S(=O)(=O)c1cccc(c1)C#N)C(=O)c1ccccn1
Show InChI InChI=1S/C29H22FN5O3S/c30-23-7-9-24(10-8-23)35-27-15-22-11-13-34(39(37,38)25-5-3-4-20(14-25)17-31)19-29(22,16-21(27)18-33-35)28(36)26-6-1-2-12-32-26/h1-10,12,14-15,18H,11,13,16,19H2/t29-/m0/s1
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0.140n/an/an/an/an/an/an/an/a



Corcept Therapeutics

Curated by ChEMBL


Assay Description
Binding affinity to human recombinant glucocorticoid receptor by fluorescence polarization assay


Bioorg Med Chem Lett 25: 5720-5 (2015)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50265804
PNG
(CHEMBL3735124)
Show SMILES Cc1cccc(c1)S(=O)(=O)N1CCC2=Cc3c(C[C@@]2(C1)C(=O)c1ccccn1)cnn3-c1ccc(F)cc1
Show InChI InChI=1S/C29H25FN4O3S/c1-20-5-4-6-25(15-20)38(36,37)33-14-12-22-16-27-21(18-32-34(27)24-10-8-23(30)9-11-24)17-29(22,19-33)28(35)26-7-2-3-13-31-26/h2-11,13,15-16,18H,12,14,17,19H2,1H3/t29-/m0/s1
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0.140n/an/an/an/an/an/an/an/a



Corcept Therapeutics

Curated by ChEMBL


Assay Description
Displacement of fluormone GS Red from human glucocorticoid receptor after 4 hrs by fluorescence polarization assay


J Med Chem 60: 3405-3421 (2017)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50265803
PNG
(CHEMBL4077976)
Show SMILES Cc1ccnc(c1)C(=O)[C@@]12CN(CCC1=Cc1c(C2)cnn1-c1ccc(F)cc1)S(=O)(=O)c1cc(F)cc(F)c1
Show InChI InChI=1S/C29H23F3N4O3S/c1-18-6-8-33-26(10-18)28(37)29-15-19-16-34-36(24-4-2-21(30)3-5-24)27(19)11-20(29)7-9-35(17-29)40(38,39)25-13-22(31)12-23(32)14-25/h2-6,8,10-14,16H,7,9,15,17H2,1H3/t29-/m0/s1
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0.140n/an/an/an/an/an/an/an/a



Corcept Therapeutics

Curated by ChEMBL


Assay Description
Displacement of fluormone GS Red from human glucocorticoid receptor after 4 hrs by fluorescence polarization assay


J Med Chem 60: 3405-3421 (2017)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50265730
PNG
(CHEMBL4101325)
Show SMILES Cc1ccnc(c1)C(=O)[C@@]12CN(CCC1=Cc1c(C2)cnn1-c1ccc(F)cc1)S(=O)(=O)c1cccc(c1)C#N
Show InChI InChI=1S/C30H24FN5O3S/c1-20-9-11-33-27(13-20)29(37)30-16-22-18-34-36(25-7-5-24(31)6-8-25)28(22)15-23(30)10-12-35(19-30)40(38,39)26-4-2-3-21(14-26)17-32/h2-9,11,13-15,18H,10,12,16,19H2,1H3/t30-/m0/s1
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0.150n/an/an/an/an/an/an/an/a



Corcept Therapeutics

Curated by ChEMBL


Assay Description
Displacement of fluormone GS Red from human glucocorticoid receptor after 4 hrs by fluorescence polarization assay


J Med Chem 60: 3405-3421 (2017)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50499257
PNG
(CHEMBL3736457)
Show SMILES Fc1ccc(cc1)-n1ncc2C[C@@]3(CN(CCC3=Cc12)S(=O)(=O)c1ccc(cc1)C(F)(F)F)C(=O)c1cocn1
Show InChI InChI=1S/C27H20F4N4O4S/c28-20-3-5-21(6-4-20)35-24-11-19-9-10-34(40(37,38)22-7-1-18(2-8-22)27(29,30)31)15-26(19,12-17(24)13-33-35)25(36)23-14-39-16-32-23/h1-8,11,13-14,16H,9-10,12,15H2/t26-/m0/s1
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0.160n/an/an/an/an/an/an/an/a



Corcept Therapeutics

Curated by ChEMBL


Assay Description
Binding affinity to human recombinant glucocorticoid receptor by fluorescence polarization assay


Bioorg Med Chem Lett 25: 5720-5 (2015)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50265674
PNG
(CHEMBL3734774)
Show SMILES Fc1ccc(cc1)-n1ncc2C[C@@]3(CN(CCC3=Cc12)S(=O)(=O)c1ccc(cc1)C(F)(F)F)C(=O)c1ccccn1
Show InChI InChI=1S/C29H22F4N4O3S/c30-22-6-8-23(9-7-22)37-26-15-21-12-14-36(41(39,40)24-10-4-20(5-11-24)29(31,32)33)18-28(21,16-19(26)17-35-37)27(38)25-3-1-2-13-34-25/h1-11,13,15,17H,12,14,16,18H2/t28-/m0/s1
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0.160n/an/an/an/an/an/an/an/a



Corcept Therapeutics

Curated by ChEMBL


Assay Description
Binding affinity to human recombinant glucocorticoid receptor by fluorescence polarization assay


Bioorg Med Chem Lett 25: 5720-5 (2015)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50499256
PNG
(CHEMBL3736390)
Show SMILES Fc1ccc(cc1)-n1ncc2C[C@@]3(CN(CCC3=Cc12)S(=O)(=O)c1ccc(cc1)C(F)(F)F)C(=O)c1ccco1
Show InChI InChI=1S/C28H21F4N3O4S/c29-21-5-7-22(8-6-21)35-24-14-20-11-12-34(40(37,38)23-9-3-19(4-10-23)28(30,31)32)17-27(20,15-18(24)16-33-35)26(36)25-2-1-13-39-25/h1-10,13-14,16H,11-12,15,17H2/t27-/m0/s1
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0.170n/an/an/an/an/an/an/an/a



Corcept Therapeutics

Curated by ChEMBL


Assay Description
Binding affinity to human recombinant glucocorticoid receptor by fluorescence polarization assay


Bioorg Med Chem Lett 25: 5720-5 (2015)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50499245
PNG
(CHEMBL3735710)
Show SMILES COc1cccc(c1)S(=O)(=O)N1CCC2=Cc3c(C[C@@]2(C1)C(=O)c1ccccn1)cnn3-c1ccc(F)cc1
Show InChI InChI=1S/C29H25FN4O4S/c1-38-24-5-4-6-25(16-24)39(36,37)33-14-12-21-15-27-20(18-32-34(27)23-10-8-22(30)9-11-23)17-29(21,19-33)28(35)26-7-2-3-13-31-26/h2-11,13,15-16,18H,12,14,17,19H2,1H3/t29-/m0/s1
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0.190n/an/an/an/an/an/an/an/a



Corcept Therapeutics

Curated by ChEMBL


Assay Description
Binding affinity to human recombinant glucocorticoid receptor by fluorescence polarization assay


Bioorg Med Chem Lett 25: 5720-5 (2015)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50265806
PNG
(CHEMBL4074627)
Show SMILES CCc1ccnc(c1)C(=O)[C@@]12CN(CCC1=Cc1c(C2)cnn1-c1ccc(F)cc1)S(=O)(=O)c1cccc(c1)C#N
Show InChI InChI=1S/C31H26FN5O3S/c1-2-21-10-12-34-28(15-21)30(38)31-17-23-19-35-37(26-8-6-25(32)7-9-26)29(23)16-24(31)11-13-36(20-31)41(39,40)27-5-3-4-22(14-27)18-33/h3-10,12,14-16,19H,2,11,13,17,20H2,1H3/t31-/m0/s1
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0.190n/an/an/an/an/an/an/an/a



Corcept Therapeutics

Curated by ChEMBL


Assay Description
Displacement of fluormone GS Red from human glucocorticoid receptor after 4 hrs by fluorescence polarization assay


J Med Chem 60: 3405-3421 (2017)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50265802
PNG
(CHEMBL4089006)
Show SMILES Cc1cccc(c1)S(=O)(=O)N1CCC2=Cc3c(C[C@@]2(C1)C(=O)c1cccc(C)n1)cnn3-c1ccc(F)cc1
Show InChI InChI=1S/C30H27FN4O3S/c1-20-5-3-7-26(15-20)39(37,38)34-14-13-23-16-28-22(18-32-35(28)25-11-9-24(31)10-12-25)17-30(23,19-34)29(36)27-8-4-6-21(2)33-27/h3-12,15-16,18H,13-14,17,19H2,1-2H3/t30-/m0/s1
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0.200n/an/an/an/an/an/an/an/a



Corcept Therapeutics

Curated by ChEMBL


Assay Description
Displacement of fluormone GS Red from human glucocorticoid receptor after 4 hrs by fluorescence polarization assay


J Med Chem 60: 3405-3421 (2017)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50499254
PNG
(CHEMBL3734789)
Show SMILES Fc1ccc(cc1)-n1ncc2C[C@@]3(CN(CCC3=Cc12)S(=O)(=O)c1ccc(cc1)C(F)(F)F)C(=O)c1cnccn1
Show InChI InChI=1S/C28H21F4N5O3S/c29-21-3-5-22(6-4-21)37-25-13-20-9-12-36(41(39,40)23-7-1-19(2-8-23)28(30,31)32)17-27(20,14-18(25)15-35-37)26(38)24-16-33-10-11-34-24/h1-8,10-11,13,15-16H,9,12,14,17H2/t27-/m0/s1
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0.210n/an/an/an/an/an/an/an/a



Corcept Therapeutics

Curated by ChEMBL


Assay Description
Binding affinity to human recombinant glucocorticoid receptor by fluorescence polarization assay


Bioorg Med Chem Lett 25: 5720-5 (2015)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50499248
PNG
(CHEMBL3735549)
Show SMILES Cc1ccccc1S(=O)(=O)N1CCC2=Cc3c(C[C@@]2(C1)C(=O)c1ccccn1)cnn3-c1ccc(F)cc1
Show InChI InChI=1S/C29H25FN4O3S/c1-20-6-2-3-8-27(20)38(36,37)33-15-13-22-16-26-21(18-32-34(26)24-11-9-23(30)10-12-24)17-29(22,19-33)28(35)25-7-4-5-14-31-25/h2-12,14,16,18H,13,15,17,19H2,1H3/t29-/m0/s1
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0.210n/an/an/an/an/an/an/an/a



Corcept Therapeutics

Curated by ChEMBL


Assay Description
Binding affinity to human recombinant glucocorticoid receptor by fluorescence polarization assay


Bioorg Med Chem Lett 25: 5720-5 (2015)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50265799
PNG
(CHEMBL4096930)
Show SMILES Cc1ccnc(c1)C(=O)[C@@]12CN(CCC1=Cc1c(C2)cnn1-c1ccc(F)cc1)S(=O)(=O)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C30H24F4N4O3S/c1-19-9-11-35-26(13-19)28(39)29-16-20-17-36-38(24-7-5-23(31)6-8-24)27(20)15-21(29)10-12-37(18-29)42(40,41)25-4-2-3-22(14-25)30(32,33)34/h2-9,11,13-15,17H,10,12,16,18H2,1H3/t29-/m0/s1
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0.210n/an/an/an/an/an/an/an/a



Corcept Therapeutics

Curated by ChEMBL


Assay Description
Displacement of fluormone GS Red from human glucocorticoid receptor after 4 hrs by fluorescence polarization assay


J Med Chem 60: 3405-3421 (2017)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50499253
PNG
(CHEMBL3735496)
Show SMILES Cc1ccc(cc1)S(=O)(=O)N1CCC2=Cc3c(C[C@@]2(C1)C(=O)c1ccccn1)cnn3-c1ccc(F)cc1
Show InChI InChI=1S/C29H25FN4O3S/c1-20-5-11-25(12-6-20)38(36,37)33-15-13-22-16-27-21(18-32-34(27)24-9-7-23(30)8-10-24)17-29(22,19-33)28(35)26-4-2-3-14-31-26/h2-12,14,16,18H,13,15,17,19H2,1H3/t29-/m0/s1
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0.220n/an/an/an/an/an/an/an/a



Corcept Therapeutics

Curated by ChEMBL


Assay Description
Binding affinity to human recombinant glucocorticoid receptor by fluorescence polarization assay


Bioorg Med Chem Lett 25: 5720-5 (2015)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50265795
PNG
(CHEMBL3736000)
Show SMILES Fc1ccc(cc1)-n1ncc2C[C@@]3(CN(CCC3=Cc12)S(=O)(=O)c1ccc(F)c(F)c1)C(=O)c1ccccn1
Show InChI InChI=1S/C28H21F3N4O3S/c29-20-4-6-21(7-5-20)35-26-13-19-10-12-34(39(37,38)22-8-9-23(30)24(31)14-22)17-28(19,15-18(26)16-33-35)27(36)25-3-1-2-11-32-25/h1-9,11,13-14,16H,10,12,15,17H2/t28-/m0/s1
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0.220n/an/an/an/an/an/an/an/a



Corcept Therapeutics

Curated by ChEMBL


Assay Description
Binding affinity to human recombinant glucocorticoid receptor by fluorescence polarization assay


Bioorg Med Chem Lett 25: 5720-5 (2015)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50265795
PNG
(CHEMBL3736000)
Show SMILES Fc1ccc(cc1)-n1ncc2C[C@@]3(CN(CCC3=Cc12)S(=O)(=O)c1ccc(F)c(F)c1)C(=O)c1ccccn1
Show InChI InChI=1S/C28H21F3N4O3S/c29-20-4-6-21(7-5-20)35-26-13-19-10-12-34(39(37,38)22-8-9-23(30)24(31)14-22)17-28(19,15-18(26)16-33-35)27(36)25-3-1-2-11-32-25/h1-9,11,13-14,16H,10,12,15,17H2/t28-/m0/s1
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0.220n/an/an/an/an/an/an/an/a



Corcept Therapeutics

Curated by ChEMBL


Assay Description
Displacement of fluormone GS Red from human glucocorticoid receptor after 4 hrs by fluorescence polarization assay


J Med Chem 60: 3405-3421 (2017)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50499247
PNG
(CHEMBL3735209)
Show SMILES Fc1ccc(cc1)-n1ncc2C[C@@]3(CN(CCC3=Cc12)S(=O)(=O)c1ccc(cc1)C(F)(F)F)C(=O)c1nccs1
Show InChI InChI=1S/C27H20F4N4O3S2/c28-20-3-5-21(6-4-20)35-23-13-19-9-11-34(40(37,38)22-7-1-18(2-8-22)27(29,30)31)16-26(19,14-17(23)15-33-35)24(36)25-32-10-12-39-25/h1-8,10,12-13,15H,9,11,14,16H2/t26-/m0/s1
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0.230n/an/an/an/an/an/an/an/a



Corcept Therapeutics

Curated by ChEMBL


Assay Description
Binding affinity to human recombinant glucocorticoid receptor by fluorescence polarization assay


Bioorg Med Chem Lett 25: 5720-5 (2015)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50265735
PNG
(CHEMBL4073649)
Show SMILES Fc1ccc(cc1)-n1ncc2C[C@@]3(CN(CCC3=Cc12)S(=O)(=O)c1ccc(F)c(F)c1)C(=O)c1nccs1
Show InChI InChI=1S/C26H19F3N4O3S2/c27-18-1-3-19(4-2-18)33-23-11-17-7-9-32(38(35,36)20-5-6-21(28)22(29)12-20)15-26(17,13-16(23)14-31-33)24(34)25-30-8-10-37-25/h1-6,8,10-12,14H,7,9,13,15H2/t26-/m0/s1
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0.230n/an/an/an/an/an/an/an/a



Corcept Therapeutics

Curated by ChEMBL


Assay Description
Displacement of fluormone GS Red from human glucocorticoid receptor after 4 hrs by fluorescence polarization assay


J Med Chem 60: 3405-3421 (2017)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50499249
PNG
(CHEMBL3735564)
Show SMILES Fc1ccc(cc1)-n1ncc2C[C@@]3(CN(CCC3=Cc12)S(=O)(=O)c1cccc(Cl)c1)C(=O)c1ccccn1
Show InChI InChI=1S/C28H22ClFN4O3S/c29-21-4-3-5-24(15-21)38(36,37)33-13-11-20-14-26-19(17-32-34(26)23-9-7-22(30)8-10-23)16-28(20,18-33)27(35)25-6-1-2-12-31-25/h1-10,12,14-15,17H,11,13,16,18H2/t28-/m0/s1
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0.25n/an/an/an/an/an/an/an/a



Corcept Therapeutics

Curated by ChEMBL


Assay Description
Binding affinity to human recombinant glucocorticoid receptor by fluorescence polarization assay


Bioorg Med Chem Lett 25: 5720-5 (2015)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50265674
PNG
(CHEMBL3734774)
Show SMILES Fc1ccc(cc1)-n1ncc2C[C@@]3(CN(CCC3=Cc12)S(=O)(=O)c1ccc(cc1)C(F)(F)F)C(=O)c1ccccn1
Show InChI InChI=1S/C29H22F4N4O3S/c30-22-6-8-23(9-7-22)37-26-15-21-12-14-36(41(39,40)24-10-4-20(5-11-24)29(31,32)33)18-28(21,16-19(26)17-35-37)27(38)25-3-1-2-13-34-25/h1-11,13,15,17H,12,14,16,18H2/t28-/m0/s1
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0.280n/an/an/an/an/an/an/an/a



Corcept Therapeutics

Curated by ChEMBL


Assay Description
Displacement of fluormone GS Red from human glucocorticoid receptor after 4 hrs by fluorescence polarization assay


J Med Chem 60: 3405-3421 (2017)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50265805
PNG
(CHEMBL3735218)
Show SMILES Fc1ccc(cc1)-n1ncc2C[C@@]3(CN(CCC3=Cc12)S(=O)(=O)c1ccc(c(F)c1)C(F)(F)F)C(=O)c1ccccn1
Show InChI InChI=1S/C29H21F5N4O3S/c30-20-4-6-21(7-5-20)38-26-13-19-10-12-37(42(40,41)22-8-9-23(24(31)14-22)29(32,33)34)17-28(19,15-18(26)16-36-38)27(39)25-3-1-2-11-35-25/h1-9,11,13-14,16H,10,12,15,17H2/t28-/m0/s1
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0.290n/an/an/an/an/an/an/an/a



Corcept Therapeutics

Curated by ChEMBL


Assay Description
Displacement of fluormone GS Red from human glucocorticoid receptor after 4 hrs by fluorescence polarization assay


J Med Chem 60: 3405-3421 (2017)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50265807
PNG
(CHEMBL4084014)
Show SMILES Cc1cnc(s1)C(=O)[C@@]12CN(CCC1=Cc1c(C2)cnn1-c1ccc(F)cc1)S(=O)(=O)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C28H22F4N4O3S2/c1-17-14-33-26(40-17)25(37)27-13-18-15-34-36(22-7-5-21(29)6-8-22)24(18)12-19(27)9-10-35(16-27)41(38,39)23-4-2-3-20(11-23)28(30,31)32/h2-8,11-12,14-15H,9-10,13,16H2,1H3/t27-/m0/s1
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0.290n/an/an/an/an/an/an/an/a



Corcept Therapeutics

Curated by ChEMBL


Assay Description
Displacement of fluormone GS Red from human glucocorticoid receptor after 4 hrs by fluorescence polarization assay


J Med Chem 60: 3405-3421 (2017)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50265805
PNG
(CHEMBL3735218)
Show SMILES Fc1ccc(cc1)-n1ncc2C[C@@]3(CN(CCC3=Cc12)S(=O)(=O)c1ccc(c(F)c1)C(F)(F)F)C(=O)c1ccccn1
Show InChI InChI=1S/C29H21F5N4O3S/c30-20-4-6-21(7-5-20)38-26-13-19-10-12-37(42(40,41)22-8-9-23(24(31)14-22)29(32,33)34)17-28(19,15-18(26)16-36-38)27(39)25-3-1-2-11-35-25/h1-9,11,13-14,16H,10,12,15,17H2/t28-/m0/s1
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0.290n/an/an/an/an/an/an/an/a



Corcept Therapeutics

Curated by ChEMBL


Assay Description
Binding affinity to human recombinant glucocorticoid receptor by fluorescence polarization assay


Bioorg Med Chem Lett 25: 5720-5 (2015)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50372966
PNG
(CHEMBL270668)
Show SMILES COCCOC[C@@]12CN(CCC1=Cc1c(C2)cnn1-c1ccc(F)cc1)S(=O)(=O)c1ccc(C)cc1
Show InChI InChI=1S/C27H30FN3O4S/c1-20-3-9-25(10-4-20)36(32,33)30-12-11-22-15-26-21(16-27(22,18-30)19-35-14-13-34-2)17-29-31(26)24-7-5-23(28)6-8-24/h3-10,15,17H,11-14,16,18-19H2,1-2H3/t27-/m1/s1
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0.300n/an/an/an/an/an/an/an/a



Corcept Therapeutics

Curated by ChEMBL


Assay Description
Displacement of [3H]dexamethasone from human recombinant GR


Bioorg Med Chem Lett 18: 1312-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.027
BindingDB Entry DOI: 10.7270/Q22Z16CP
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50265762
PNG
(CHEMBL4066669)
Show SMILES Cc1cnc(s1)C(=O)[C@@]12CN(CCC1=Cc1c(C2)cnn1-c1ccc(F)cc1)S(=O)(=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C27H21Cl2FN4O3S2/c1-16-13-31-26(38-16)25(35)27-12-17-14-32-34(20-4-2-19(30)3-5-20)24(17)10-18(27)8-9-33(15-27)39(36,37)21-6-7-22(28)23(29)11-21/h2-7,10-11,13-14H,8-9,12,15H2,1H3/t27-/m0/s1
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0.320n/an/an/an/an/an/an/an/a



Corcept Therapeutics

Curated by ChEMBL


Assay Description
Displacement of fluormone GS Red from human glucocorticoid receptor after 4 hrs by fluorescence polarization assay


J Med Chem 60: 3405-3421 (2017)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50265731
PNG
(CHEMBL4091787)
Show SMILES Fc1ccc(cc1)-n1ncc2C[C@@]3(CN(CCC3=Cc12)S(=O)(=O)c1cccc(c1)C#N)C(=O)c1cc(ccn1)C(F)(F)F
Show InChI InChI=1S/C30H21F4N5O3S/c31-23-4-6-24(7-5-23)39-27-14-21-9-11-38(43(41,42)25-3-1-2-19(12-25)16-35)18-29(21,15-20(27)17-37-39)28(40)26-13-22(8-10-36-26)30(32,33)34/h1-8,10,12-14,17H,9,11,15,18H2/t29-/m0/s1
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0.320n/an/an/an/an/an/an/an/a



Corcept Therapeutics

Curated by ChEMBL


Assay Description
Displacement of fluormone GS Red from human glucocorticoid receptor after 4 hrs by fluorescence polarization assay


J Med Chem 60: 3405-3421 (2017)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50499250
PNG
(CHEMBL3735251)
Show SMILES Fc1ccc(cc1)-n1ncc2C[C@@]3(CN(CCC3=Cc12)S(=O)(=O)c1ccc(cc1)C(F)(F)F)C(=O)c1cncs1
Show InChI InChI=1S/C27H20F4N4O3S2/c28-20-3-5-21(6-4-20)35-23-11-19-9-10-34(40(37,38)22-7-1-18(2-8-22)27(29,30)31)15-26(19,12-17(23)13-33-35)25(36)24-14-32-16-39-24/h1-8,11,13-14,16H,9-10,12,15H2/t26-/m0/s1
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0.330n/an/an/an/an/an/an/an/a



Corcept Therapeutics

Curated by ChEMBL


Assay Description
Binding affinity to human recombinant glucocorticoid receptor by fluorescence polarization assay


Bioorg Med Chem Lett 25: 5720-5 (2015)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM18627
PNG
((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Show SMILES CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(cc1)N(C)C
Show InChI InChI=1/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/s2
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0.400n/an/an/an/an/an/an/an/a



Corcept Therapeutics

Curated by ChEMBL


Assay Description
Displacement of [3H]dexamethasone from human glucocorticoid receptor expressed in recombinant baculovirus


Bioorg Med Chem Lett 17: 5704-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.055
BindingDB Entry DOI: 10.7270/Q2FX7B8B
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM18627
PNG
((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Show SMILES CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(cc1)N(C)C
Show InChI InChI=1/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/s2
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0.400n/an/an/an/an/an/an/an/a



Corcept Therapeutics

Curated by ChEMBL


Assay Description
Displacement of [3H]dexamethasone from human recombinant GR


Bioorg Med Chem Lett 18: 1312-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.027
BindingDB Entry DOI: 10.7270/Q22Z16CP
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50499251
PNG
(CHEMBL3736175)
Show SMILES Fc1ccc(cc1)-n1ncc2C[C@@]3(CN(CCC3=Cc12)S(=O)(=O)c1ccc(cc1)C(F)(F)F)C(=O)c1cccs1
Show InChI InChI=1S/C28H21F4N3O3S2/c29-21-5-7-22(8-6-21)35-24-14-20-11-12-34(40(37,38)23-9-3-19(4-10-23)28(30,31)32)17-27(20,15-18(24)16-33-35)26(36)25-2-1-13-39-25/h1-10,13-14,16H,11-12,15,17H2/t27-/m0/s1
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0.410n/an/an/an/an/an/an/an/a



Corcept Therapeutics

Curated by ChEMBL


Assay Description
Binding affinity to human recombinant glucocorticoid receptor by fluorescence polarization assay


Bioorg Med Chem Lett 25: 5720-5 (2015)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50265800
PNG
(CHEMBL4104661)
Show SMILES Cc1ccnc(c1)C(=O)[C@@]12CN(CCC1=Cc1c(C2)cnn1-c1ccc(F)cc1)S(=O)(=O)c1ccc(c(F)c1)C(F)(F)F
Show InChI InChI=1S/C30H23F5N4O3S/c1-18-8-10-36-26(12-18)28(40)29-15-19-16-37-39(22-4-2-21(31)3-5-22)27(19)13-20(29)9-11-38(17-29)43(41,42)23-6-7-24(25(32)14-23)30(33,34)35/h2-8,10,12-14,16H,9,11,15,17H2,1H3/t29-/m0/s1
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0.420n/an/an/an/an/an/an/an/a



Corcept Therapeutics

Curated by ChEMBL


Assay Description
Displacement of fluormone GS Red from human glucocorticoid receptor after 4 hrs by fluorescence polarization assay


J Med Chem 60: 3405-3421 (2017)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50499258
PNG
(CHEMBL3736379)
Show SMILES Fc1ccc(cc1)-n1ncc2C[C@@]3(CN(CCC3=Cc12)S(=O)(=O)c1ccc(cc1)C(F)(F)F)C(=O)c1ncc[nH]1
Show InChI InChI=1S/C27H21F4N5O3S/c28-20-3-5-21(6-4-20)36-23-13-19-9-12-35(40(38,39)22-7-1-18(2-8-22)27(29,30)31)16-26(19,14-17(23)15-34-36)24(37)25-32-10-11-33-25/h1-8,10-11,13,15H,9,12,14,16H2,(H,32,33)/t26-/m0/s1
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0.470n/an/an/an/an/an/an/an/a



Corcept Therapeutics

Curated by ChEMBL


Assay Description
Binding affinity to human recombinant glucocorticoid receptor by fluorescence polarization assay


Bioorg Med Chem Lett 25: 5720-5 (2015)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50265732
PNG
(CHEMBL4070919)
Show SMILES Fc1ccc(cc1)-n1ncc2C[C@@]3(CN(CCC3=Cc12)S(=O)(=O)c1cccc(c1)C(F)(F)F)C(=O)c1nccs1
Show InChI InChI=1S/C27H20F4N4O3S2/c28-20-4-6-21(7-5-20)35-23-13-18-8-10-34(40(37,38)22-3-1-2-19(12-22)27(29,30)31)16-26(18,14-17(23)15-33-35)24(36)25-32-9-11-39-25/h1-7,9,11-13,15H,8,10,14,16H2/t26-/m0/s1
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0.480n/an/an/an/an/an/an/an/a



Corcept Therapeutics

Curated by ChEMBL


Assay Description
Displacement of fluormone GS Red from human glucocorticoid receptor after 4 hrs by fluorescence polarization assay


J Med Chem 60: 3405-3421 (2017)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50372977
PNG
(CHEMBL255369)
Show SMILES COC[C@@]12CN(CCC1=Cc1c(C2)cnn1-c1ccc(F)cc1)S(=O)(=O)c1ccc(C)cc1
Show InChI InChI=1S/C25H26FN3O3S/c1-18-3-9-23(10-4-18)33(30,31)28-12-11-20-13-24-19(14-25(20,16-28)17-32-2)15-27-29(24)22-7-5-21(26)6-8-22/h3-10,13,15H,11-12,14,16-17H2,1-2H3/t25-/m1/s1
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0.5n/an/an/an/an/an/an/an/a



Corcept Therapeutics

Curated by ChEMBL


Assay Description
Displacement of [3H]dexamethasone from human recombinant GR


Bioorg Med Chem Lett 18: 1312-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.027
BindingDB Entry DOI: 10.7270/Q22Z16CP
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50372975
PNG
(CHEMBL270667)
Show SMILES COCCOC[C@@]12CN(CCC1=Cc1c(C2)cnn1-c1ccc(F)cc1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C26H28FN3O4S/c1-33-13-14-34-19-26-16-20-17-28-30(23-9-7-22(27)8-10-23)25(20)15-21(26)11-12-29(18-26)35(31,32)24-5-3-2-4-6-24/h2-10,15,17H,11-14,16,18-19H2,1H3/t26-/m1/s1
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0.5n/an/an/an/an/an/an/an/a



Corcept Therapeutics

Curated by ChEMBL


Assay Description
Displacement of [3H]dexamethasone from human recombinant GR


Bioorg Med Chem Lett 18: 1312-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.027
BindingDB Entry DOI: 10.7270/Q22Z16CP
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50265815
PNG
(CHEMBL4065064)
Show SMILES Fc1ccc(cc1)-n1ncc2C[C@@]3(CN(CCC3=Cc12)S(=O)(=O)c1ccc(Cl)c(Cl)c1)C(=O)c1nccs1
Show InChI InChI=1S/C26H19Cl2FN4O3S2/c27-21-6-5-20(12-22(21)28)38(35,36)32-9-7-17-11-23-16(14-31-33(23)19-3-1-18(29)2-4-19)13-26(17,15-32)24(34)25-30-8-10-37-25/h1-6,8,10-12,14H,7,9,13,15H2/t26-/m0/s1
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0.590n/an/an/an/an/an/an/an/a



Corcept Therapeutics

Curated by ChEMBL


Assay Description
Displacement of fluormone GS Red from human glucocorticoid receptor after 4 hrs by fluorescence polarization assay


J Med Chem 60: 3405-3421 (2017)

More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50372965
PNG
(CHEMBL442803)
Show SMILES COCCOC[C@@]12CN(CCC1=Cc1c(C2)cnn1-c1ccc(F)cc1)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C26H27F2N3O4S/c1-34-12-13-35-18-26-15-19-16-29-31(23-6-2-21(27)3-7-23)25(19)14-20(26)10-11-30(17-26)36(32,33)24-8-4-22(28)5-9-24/h2-9,14,16H,10-13,15,17-18H2,1H3/t26-/m1/s1
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0.600n/an/an/an/an/an/an/an/a



Corcept Therapeutics

Curated by ChEMBL


Assay Description
Displacement of [3H]dexamethasone from human recombinant GR


Bioorg Med Chem Lett 18: 1312-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.027
BindingDB Entry DOI: 10.7270/Q22Z16CP
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50372937
PNG
(CHEMBL257461)
Show SMILES Fc1ccc(cc1)-n1ncc2C[C@]3(CN4CCOCC4)CN(CCC3=Cc12)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C27H29FN4O3S/c28-23-6-8-24(9-7-23)32-26-16-22-10-11-31(36(33,34)25-4-2-1-3-5-25)20-27(22,17-21(26)18-29-32)19-30-12-14-35-15-13-30/h1-9,16,18H,10-15,17,19-20H2/t27-/m0/s1
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0.600n/an/an/an/an/an/an/an/a



Corcept Therapeutics

Curated by ChEMBL


Assay Description
Displacement of [3H]dexamethasone from human recombinant GR


Bioorg Med Chem Lett 18: 1312-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.027
BindingDB Entry DOI: 10.7270/Q22Z16CP
More data for this
Ligand-Target Pair
Glucocorticoid receptor


(Homo sapiens (Human))
BDBM50113780
PNG
((2R,4aS,10aR)-4a-benzyl-2-(prop-1-ynyl)-1,2,3,4,4a...)
Show SMILES CC#C[C@@]1(O)CC[C@]2(Cc3ccccc3)[C@H](CCc3cc(O)ccc23)C1
Show InChI InChI=1S/C24H26O2/c1-2-12-23(26)13-14-24(16-18-6-4-3-5-7-18)20(17-23)9-8-19-15-21(25)10-11-22(19)24/h3-7,10-11,15,20,25-26H,8-9,13-14,16-17H2,1H3/t20-,23-,24+/m1/s1
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0.600n/an/an/an/an/an/an/an/a



Corcept Therapeutics

Curated by ChEMBL


Assay Description
Displacement of [3H]dexamethasone from human glucocorticoid receptor expressed in recombinant baculovirus


Bioorg Med Chem Lett 17: 5704-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.055
BindingDB Entry DOI: 10.7270/Q2FX7B8B
More data for this
Ligand-Target Pair
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